Provided is a novel noxious organism control agent, particularly an insecticide or a miticide. A condensed heterocyclic compound represented by formula (1) [wherein D substituted by -S(O)nR1 represents a ring represented by D1, D2 or D3; Q represents a ring represented by Q1, Q2, Q3 or Q4; R1 represents a (C1-C6) alkyl group, a C2-C6 alkenyl group, a C2-C6 haloalkenyl group, a C2-C6 alkynyl group, a C2-C6 haloalkynyl group, a C3-C6 cycloalkyl group, a C3-C6 halocycloalkyl group, a C3-C6 cycloalkyl-(C1-C6) alkyl group, a C3-C6 halocycloalkyl-(C1-C6) alkyl group or a hydroxy-(C1-C6) alkyl group each of which is optionally substituted by a C1-C6 alkyl group, a C1-C6 haloalkyl group or R1a; R1a represents a C1-C8 alkoxycarbonyl group; and n represents an integer of 0, 1 or 2], a salt of the condensed heterocyclic compound, or an N-oxide of the condensed heterocyclic compound or the salt.
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/5025 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
[Problem] To provide a novel agricultural chemical, and particularly an herbicide. [Solution] A ketone or oxime compound represented by formula (1) and a herbicide containing the same (in the formula: B represents B-1, B-2, or B-3; Q represents an oxygen atom, =NOR7, etc.; R6 represents a hydrogen atom, C1-C6 alkyl group, etc.; R7 represents a hydrogen atom, C1-C6 alkyl group, etc.; R8a, R8b, R9a, R9b, R10, R11, R12, R13, and R14 each independently represent a hydrogen atom or C1-C6 alkyl; m represents the integer 1 or 2; and n represents the integer 0, 1, or 2).
C07C 49/747 - Unsaturated compounds containing a keto group being part of a ring containing hydroxy groups containing six-membered aromatic rings
A01N 35/06 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
A01N 35/10 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
C07C 251/40 - Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
3.
ION COMPLEX MATERIAL HAVING FUNCTION OF INHIBITING ADHESION OF BIOLOGICAL SUBSTANCE AND METHOD FOR MANUFACTURING THE SAME
The present invention provides a copolymer or the like obtained by polymerizing a monomer mixture including at least compounds represented by formulas (A), (B), and (C) (in the formulas, Ta, Tb, Tc, Ua1, Ua2, Ub1, Ub2, Ub3, Qa, Qb, Qc, Ra, Rb, Rc, An-, and m are as defined in the description and claims). The copolymer of the present invention can be utilized as an ion complex material having an exceptional ability to inhibit adhesion of biological materials.
C08F 230/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium, or a metal containing phosphorus
A61L 27/00 - Materials for prostheses or for coating prostheses
A61L 31/00 - Materials for other surgical articles
4.
INSECTICIDAL, MITICIDAL, NEMATICIDAL, MOLLUSCICIDAL, MICROBICIDAL, OR BACTERICIDAL COMPOSITION AND METHOD FOR CONTROLLING PEST
[Problem] To provide an insecticide, miticide, nematicide, molluscicide, disinfectant, or bactericide composition, and a pest control method. [Solution] An insecticide, miticide, nematicide, molluscicide, disinfectant, or bactericide composition containing one or two substances selected from 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole-3-yl]-2-methyl-N-[2- oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]benzamide and (Z)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(methoxyiminomethyl)-2-methylbenzoic acid amide, and one or more substances selected from known insecticide, miticide, nematicide, molluscicide, disinfectant, or bactericide compounds.
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
A01N 43/22 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom rings with more than six members
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
A01N 43/713 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
A01N 47/06 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing —O—CO—O— groups; Thio-analogues thereof
A01N 47/34 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the groups , e.g. biuret; Thio-analogues thereof; Urea-aldehyde condensation products
A01N 53/06 - Esters containing the group , wherein the carbon atom marked with an asterisk is acyclic or part of a ring or ring system; Thio-analogues thereof the carbon atom marked with an asterisk being acyclic and directly bound to a carbon atom of a six-membered aromatic ring, e.g. benzyl esters; Thio-analogues thereof
A01N 53/08 - Esters containing the group , wherein the carbon atom marked with an asterisk is acyclic or part of a ring or ring system; Thio-analogues thereof the carbon atom marked with an asterisk being acyclic and directly bound to a carbon atom of a six-membered aromatic ring, e.g. benzyl esters; Thio-analogues thereof with aryloxy groups bound to the six-membered aromatic ring, e.g. phenoxybenzyl esters; Thio-analogues thereof
A composition for use as a fungicide, an insecticide, a nematicide or a bactericide, comprising synergistically effective amounts of one or more compounds selected from oxime-substituted amide compounds represented by the formula (l), or their N-oxides or salts: such as: and one or more active ingredient compounds selected from fungicidal, insecticidal, nematicidal and bactericidal compounds.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
A01N 31/16 - Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
A01N 33/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
A01N 35/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio-analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
A01N 37/24 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imides; Thio-analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
A01N 37/32 - Cyclic imides of polybasic carboxylic acids or thio-analogues thereof
A01N 37/50 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio-analogue of the nitrogen atom being doubly bound to the carbon skeleton
A01N 37/52 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
A01N 43/10 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with sulfur as the ring hetero atom
A01N 43/36 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A01N 43/84 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
A01N 45/02 - Biocides, pest repellants or attractants, or plant growth regulators containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
A01N 47/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing N—S—C≡Hal3 groups
A01N 47/12 - Carbamic acid derivatives, i.e. containing the group —O—CO—N; Thio-analogues thereof containing a —O—CO—N group, or a thio-analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
A01N 47/24 - Carbamic acid derivatives, i.e. containing the group —O—CO—N; Thio-analogues thereof containing the groups , or ; Thio-analogues thereof
A01N 47/34 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the groups , e.g. biuret; Thio-analogues thereof; Urea-aldehyde condensation products
A01N 47/38 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the group N—CO—N where at least one nitrogen atom is part of a heterocyclic ring; Thio-analogues thereof
A01N 55/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
A01N 55/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
The present invention provides a medium composition that is suitable for culturing cells or tissues in a suspended state, and that may be used to produce a sphere; to preserve, transport or proliferate a cell or tissue; or to passage culture an adherent cell. The medium composition comprises a nanofiber dispersed in a liquid medium, the nanofiber comprising a chitin and/or chitosan and no other polysaccharide.
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
C12N 1/02 - Separating microorganisms from their culture media
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
7.
ION COMPLEX MATERIAL HAVING FUNCTION OF INHIBITING ADHESION OF BIOLOGICAL SUBSTANCE AND METHOD FOR MANUFACTURING THE SAME
Provided are a coating film having a function of inhibiting adhesion of biological matter; a production method for the coating film; a polymer obtained by polymerization of a specific monomer mixture; a coating film-forming composition having a specific makeup; a production method for a copolymer-containing varnish for use as a starting material for a coating film-forming composition for forming the film; and a sol for forming a coating film. In particular, there is provided a coating film obtained by a method that includes: a step of applying, to a substrate, a coating film-forming composition containing a solvent and a copolymer that includes repeating units having organic groups represented by formula (a), and repeating units having organic groups represented by formula (b); and a step of drying at a temperature of -200°C to 200°C (in the formulas, Ua1, Ua2, Ub1, Ub2, Ub3, and An- are defined as in the present description and claims).
C09D 201/02 - Coating compositions based on unspecified macromolecular compounds characterised by the presence of specified groups
B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
B05D 7/24 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
C08F 230/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium, or a metal containing phosphorus
C08L 43/02 - Homopolymers or copolymers of monomers containing phosphorus
C08L 101/02 - Compositions of unspecified macromolecular compounds characterised by the presence of specified groups
Provided is a blood filter that contains a porous element and a copolymer, which is present on at least a part of the surface of the porous element and which contains a repeating unit containing an organic group represented by formula (a) and a repeating unit containing an organic group represented by formula (b) (in the formulae, Ua1, Ua2, Ub1, Ub2, Ub3 and An- are as set forth in the description and the claims).
The present invention provides: a cell cultivation vessel characterized in that the surface is coated with a copolymer comprising repeating units having organic groups represented by formula (a) and repeating units having organic groups represented by formula (b); a manufacturing method therefor; and a cell aggregate-manufacturing method using same (in the formulas, Ua1, Ua2, Ub1, Ub2 and Ub3 as well as An- are as set forth in the Description and the Claims).
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
B05D 7/24 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
C08F 230/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium, or a metal containing phosphorus
C09D 133/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
C09D 133/26 - Homopolymers or copolymers of acrylamide or methacrylamide
A61L 31/00 - Materials for other surgical articles
10.
CULTURE MEDIUM COMPOSITION, AND METHOD FOR CULTURING CELL OR TISSUE USING SAID COMPOSITION
The present invention provides: a method for culturing a cell and/or a tissue, said method being characterized by culturing the cell and/or the tissue in a floated state using a culture medium composition, wherein amorphous structures are formed in a liquid culture medium, are dispersed in the solution uniformly, and substantially hold the cell and/or the tissue without substantially increasing the viscosity of the solution, so that the culture medium composition has an effect of preventing the sedimentation of the structures; and others.
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
11.
OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT
Provided is a novel pest control agent, particularly a fungicide and nematicide. An oxime-substituted amide compound represented by formula (I) [where G1 represents a structure represented by G1-1 or the like; G2 represents a structure represented by G2-2 or the like; W represents an oxygen atom or the like; X1 represents a halogen atom, methyl, trifluoromethyl, or the like; X2, X3, X4, and X5 each independently represent a hydrogen atom, halogen atom, or the like; Y1 and Y3 each independently represent a halogen atom, cyano, methyl, trifluoromethyl, C2-C6 alkynyl, or the like; Y2 and Y4 each independently represent a hydrogen atom, halogen atom, or the like; R1 represents a C1-C6 alkyl, C1-C4 haloalkyl, (C1-C4) alkyl substituted by R18, C3-C6 cycloalkyl, C3-C6 alkenyl, or the like; R2 and R3 each independently represent a hydrogen atom, methyl, or the like; R4 represents a hydrogen atom or the like; R18 represents a C3-C6 cycloalkyl, phenyl, phenyl substituted by (Z)m, or the like; Z represents a halogen atom or the like; and m represents an integer 1, 2, or 3] or a salt thereof, and a pest control agent containing these.
C07C 251/48 - Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
A01N 35/10 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
A01N 43/10 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with sulfur as the ring hetero atom
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
A61K 31/4433 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
A61K 31/4436 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
C07C 251/52 - Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
C07D 213/42 - Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
C07D 333/38 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
12.
HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells. (See Formula I)
C07D 333/38 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4436 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
A61P 25/00 - Drugs for disorders of the nervous system
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
13.
NOVEL CRYSTAL FORM OF TRICYCLIC BENZOPYRAN COMPOUND AND PRODUCTION METHOD THEREOF
[PROBLEMS TO BE SOLVED] To provide crystal forms of (3R, 4S)-7-hydroxymethyl-2,2,9-trimethyl-4- (phenethylamino)-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol that are excellent as a drug, and production methods thereof. [MEANS FOR SOLVING THE PROBLEMS] Production methods including crystallizing (3R, 4S)-7-hydroxymethyl-2,2,9- trimethyl-4-(phenethylamino)-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol from an acetate ester solvent, an aliphatic hydrocarbon solvent, a nitrile solvent, an aromatic hydrocarbon solvent, a ketone solvent or an ether solvent, and crystal forms obtained according to the methods. (see above formula)
C07D 491/052 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
14.
PRODUCTION METHOD OF ISOXAZOLINE-SUBSTITUTED BENZOIC ACID AMIDE COMPOUND
Disclosed is a production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) (see formula 1) (see formula 2) (see formula 3) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, C1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, comprising: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, -C(O)OH, -C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.
C07D 261/04 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
15.
ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE
An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: (see formula 1) wherein A1, A2 and A3 are carbon atoms, G is G-1 (see formula G-1) W is oxygen atom, X is halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, -OR5 or -S(O)r R5, when m is 2 or 3, each X may be identical with or different from each other, Y is halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, -OR5, -SR5, -NH2 or- N(R7)R6, R1 is -CH=NOR1a, R1a is C1-C6alkyl, R2 is hydrogen atom, - CH2R14a, C3-C6alkynyl or C1-C6alkoxycarbonyl, R3 is C1-C6haloalkyl, R5 is C1-C6alkyl or C1-C6haloalkyl, R6 is C1-C6alkyl, -CHO, C1-C6alkylcarbonyl or C1- C6alkoxycarbonyl, R7 is hydrogen atom or C1-C6alkyl, R14a is cyano or -OR25 useful as a pesticide, agrochemical, endo- or ecto-parasiticide, insecticide or acaricide.
C07D 261/04 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
16.
WATER DISPERSIBLE AGRICULTURAL CHEMICAL GRANULES AND METHOD OF PRODUCING THE SAME
A water dispersible agricultural chemical granule having good productivity and dispersion stability in water and a method of producing the same are provided. A water dispersible agricultural chemical granule produced by spray drying after wet pulverization of a suspension containing an agricultural chemical active component having a melting point ranging from 55 to 100°C, a surfactant and water, with a drying loss of the water dispersible agricultural chemical granule ranging from 0.1 to 5.0% by mass. A method of producing a water dispersible agricultural chemical granule including spray drying after wet pulverization of a suspension containing an agricultural chemical active component having a melting point ranging from 55 to 100°C, a surfactant and water so as to obtain the water dispersible agricultural chemical granule having drying loss ranging from 0.1 to 5.0% by mass.
A01N 25/30 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: (see formula 1) wherein A1, A2and A3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C1-C6haloalkyl, etc., Y ia halogen atm, C1-C6alkyl, etc., R1 is C1-C12alkyl arbitrarily substituted with R16, C3- C12alkenyl, arbitrarily substituted with R16 is oxygen atom or sulfur atom, -N(R20)R19, etc., R2 is hydrogen atom, C1-C4alkoxy C1-C6alkyl, etc., R3 is C1-C6haloalkyl, etc., R16 is halogen atom, cyano, phenyl substituted with (Z)p1, D-1 to D-60, E-1 to E-49, etc., R19 is phenyl, phenyl substituted with (Z)p1, etc., R20 is hydrogen atom, C1-C6alkyl, etc., Z is halogen atom, nitro, C1-C4alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.
C07D 261/04 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
C07C 25/24 - Halogenated aromatic hydrocarbons with unsaturated side chains
C07C 43/176 - Unsaturated ethers containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 43/215 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
C07C 205/11 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
C07C 251/48 - Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
C07C 271/28 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
C07C 323/09 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07F 7/08 - Compounds having one or more C—Si linkages
18.
CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION
A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1): The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability.