Mmomoommm); and calculating, using the processing device, a Mean Squared Error (MSE) lack of fit (d) of the shape fitting, wherein the calculated MSE lack of fit (d) is used to predict a type of the cardiac disease (y) in the subject.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present disclosure relates to a container for in vitro drug testing. The container comprises a receptacle having a wall made of a gel composition. The receptacle has an opening and is configured to receive a drug formulation through the opening. The gel composition is selected to simulate one or more properties of tissue.
A61J 1/00 - Containers specially adapted for medical or pharmaceutical purposes
B65D 1/00 - Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations p
3.
ANTI-INFLAMMATORY RED BLOOD CELL EXTRACELLULAR VESICLES (RBCEVS)
The present disclosure describes anti-inflammatory properties of red blood cell extracellular vesicles, e.g., as mediated by heme, hemoglobin and/or phosphatidylserine content. The present disclosure describes technologies useful for the treatment of inflammatory diseases, disorders, or conditions (e.g., atherosclerosis).
A61K 35/12 - Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
4.
AN APPARATUS, SYSTEM, AND METHOD FOR HEAT EXCHANGE
This invention provides an apparatus for heat exchange comprising a plurality of fins, and a heat transfer coil in the form of a plurality of oblong sectional tubes being arranged in a single array. The fins are arranged along a longitudinal portion of the oblong sectional tubes substantially perpendicularly for guiding incoming convective fluid towards all the oblong sectional tubes for heat exchange to be performed thereupon. Furthermore, the oblong sectional tubes of the heat transfer coil each has a substantially rectangular cross-section with round edges, or oval or elliptical cross-section, and are operable to be installed with a tilt angle for them to be tilted with a major axis of the oblong sectional tube being in respect to a direction of the incoming convective fluid flowing through the heat transfer coil. A related system and method involving the apparatus are further described.
F28F 1/02 - Tubular elements of cross-section which is non-circular
F28F 1/32 - Tubular elements or assemblies thereof with means for increasing heat-transfer area, e.g. with fins, with projections, with recesses the means being only outside the tubular element and extending transversely the means having portions engaging further tubular elements
F28D 1/053 - Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or mo with the heat-exchange conduits immersed in the body of fluid with tubular conduits the conduits being straight
A MICROCARRIER, A METHOD OF MAKING A MICROCARRIER, A SYSTEM FOR PRODUCING A CELL CULTURED FOOD PRODUCT AND A METHOD OF PRODUCING A CELL CULTURED FOOD PRODUCT
There is provided a microcarrier, a method of making a microcarrier, a system for producing a cell cultured food product and a method of producing a cell cultured food product, the microcarrier comprising, a core particle; and a coating layer disposed on a surface of the core particle; wherein the core particle and coating layer comprise one or more materials derived from plant-based sources.
The present disclosure concerns a micro-flow system for synthesis of a compound, comprising a tubing reactor configured to flow a reactant within its lumen thereof, an actuator for regulating the flow of the reactant in the lumen and a heterogeneous catalyst in fluid communication with the lumen. The present disclosure also concerns a method of micro-flow synthesising a compound using the micro-flow system.
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 8/08 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with moving particles
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
Disclosed herein is a method and an apparatus for producing graphene. The method comprises maintaining a molten salt bath in a carbonaceous environment; immersing a cathode made of copper, an anode and a reference electrode of an electrode system in the molten salt bath; and applying a negative potential at the cathode to form graphene at the cathode. The apparatus for producing graphene, comprises a cell structure including a molten salt bath maintained in a carbonaceous environment; and an electrode system having a cathode made of copper, an anode and a reference electrode immersed in the molten salt bath, wherein the electrode system is configured to provide a negative potential at the cathode for forming graphene at the cathode.
Disclosed herein is a carbon nanotube, a method of producing carbon nanotubes and an apparatus for producing carbon nanotubes. The method comprises maintaining a molten salt bath in a carbonaceous environment; immersing an iron-based cathode, an anode and a reference electrode of an electrode system in the molten salt bath; and applying a negative potential at the iron-based cathode to form the carbon nanotubes at the cathode. The apparatus for producing carbon nanotubes, comprises a molten salt bath maintained in a carbonaceous environment; and an electrode system having an iron-based cathode, an anode and a reference electrode immersed in the molten salt bath, wherein applying a negative potential at the iron- based cathode forms carbon nanotubes at the cathode. The carbon nanotube includes an iron core shell structure with an iron nucleation tip.
10.
MICROBIAL CONSORTIUM FOR PLANT GROWTH AND METHOD FOR PREPARING THE SAME
The present disclosure relates to a microbial consortium for plant growth and a method for preparing the microbial consortium The microbial consortium comprises at least two microbial strains, wherein each of the at least two microbial strains has at least a plant growth-promoting genetic element; and wherein one of the at least two microbial strains forms a syntrophic relationship with the remaining of the at least two microbial strains.
Ultra-low voltage AlGaN/GaN ultraviolet (UV) photodetectors (21) are provided. The UV photodetector (21) comprises an anode electrode (17), fin trenches (15) filled with a Schottky contact ITO layer to form fin-shaped cathode electrodes (19), and partial sidewall oxide passivation (16) around the fin trenches (15) split an intrinsic 2DEG plane (11) located in the GaN layer into islands; the 2DEG plane is isolated from the cathode electrodes (19) and transformed into field plates when biased by the anode electrode (17). Owing to the intrinsic polarization field and fin-shaped cathode electrodes (19), photo-carriers collections are effected at a bias voltage as low as about 200 mV, with a 365-nm photocurrent-to-dark current ratio above 105 and a peak UV responsivity around 103. As a result, enhanced frequency response is exhibited up to about 1 kHz on 365-nm UV switching. The photodetector (21) is suitable for future ultra-low voltage III-V circuits integration.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
SINGAPORE HEALTH SERVICES PTE LTD (Singapore)
Inventor
Yao, Xiaosai
Hong, Jing Han
Mangalvedhekar, Amrita Mandar
Ng, Shu Wen Michelle
Teh, Bin Tean
Abstract
The present invention relates, in general terms, to cancer biomarkers. Disclosed herein are methods of identifying cancers that are suitable for NF-κB inhibition therapy, and methods of selecting subjects for the same, comprising detecting an indicator that is indicative of a level or activity of Protein polybromo-1 (PB1) in a sample obtained from the subject, wherein the cancer is identified as being likely to be responsive to the inhibitor of NF-κB signalling when the level or activity of PB1 indicated by the indicator corresponds to an absence or decreased level or activity of PB1 in the sample as compared to a control.
The invention relates generally to virology. In particular, the specification teaches a method of attenuating a flavivirus, by modifying the viral genome to have a protein coding sequence having one or more synonymous codons as compared to the protein coding sequence of a parent virus, wherein the modified viral genome is associated with increased protein expression as compared to the viral genome of the parent virus in a mammalian host. Provided herein is also a modified flavivirus as defined herein.
A metal-organic framework membrane There is provided an amorphous monolithic metal-organic framework membrane which is free of grain boundaries and grain junctions. There is also provided a method of forming the same.
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
15.
COVALENT ORGANIC FRAMEWORKS USED AS SOLID PROTON-CONDUCTING MEMBRANE
Disclosed herein is a proton-conducting membrane for a proton exchange membrane fuel cell comprising a non-proton conducting covalent organic framework comprising a plurality of imine linkages and a plurality of pores each having an interior wall, and a plurality of phosphoric acid molecules disposed within the plurality of pores. Also disclosed herein is a proton exchange membrane fuel cell comprising a proton-conducting membrane as aforementioned.
C08G 83/00 - Macromolecular compounds not provided for in groups
H01M 8/103 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having nitrogen, e.g. sulfonated polybenzimidazoles [S-PBI], polybenzimidazoles with phosphoric acid, sulfonated polyamides [S-PA] or sulfonated polyphosphazenes [S-PPh]
This invention provides a slurry for use in additive manufacturing, comprising a first constituent, being a photomonomer or photopolymer, a second constituent, being a dispersant, a third constituent, being sinterable particles, and a fourth constituent, being a photoinitiator. The second constituent adsorbs to surfaces of the third constituent through at least one mode of adsorption. Further provided is a method for additive manufacturing involving the slurry.
B28B 1/00 - Producing shaped articles from the material
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
Disclosed herein an optical media, a method of making an optical media and a photovoltaic window. The optical media includes a matrix and luminescent phosphors dispersed in the matrix. The luminescent phosphors include at least one of luminescent inorganic phosphors and quantum dot nanocrystals. The optical media may be made into a thin film attached to a window glass. The luminescent phosphors emit excitation light under irradiation of the incident light, which is converted into electrical energy through the photovoltaic cells. The photovoltaic window includes a light-transmitting substrate, an optical media and a first photovoltaic cell. The optical media is attached to the front/rear main surface of the light-transmitting substrate. The first photovoltaic cell is attached to the side surface of the light-transmitting substrate. The optical media receives the incident light projected on the light-transmitting substrate and generates excitation light which is projected on the first photovoltaic cell and converted into electrical energy.
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
NATIONAL UNIVERSITY OF SINGAPORE (CHONGQING) RESEARCH INSTITUTE (China)
Inventor
Lu, Li
Wang, Yumei
Yi, Qiang
Abstract
Provided are a flame-retardant composite electrolyte, a manufacturing method, and a high-safety flame-retardant lithium battery manufactured from the flame-retardant composite electrolyte. The flame-retardant composite electrolyte comprises a porous organic-inorganic composite film and a flame-retardant gel electrolyte. The porous organic-inorganic composite film is prepared by electrospinning an organic-inorganic composite solution precursor and carrying out subsequent high-temperature heat treatment or hot pressing treatment. The flame-retardant gel electrolyte is cured/polymerized in situ in pores of the organic-inorganic composite film to prepare the flame-retardant composite electrolyte. The composite electrolyte has high thermal stability, a high electrochemical stability window (4.52 V Vs. Li/Li+, room temperature), and high ionic conductivity (~10-3 S/cm, room temperature). The high-safety flame-retardant lithium battery manufactured from the flame-retardant composite electrolyte also exhibits excellent cycle performance.
Disclosed herein is a method of separating hydrocarbons from each other, the method comprising the steps of (a) providing a metal organic framework (MOF) formed from a metal ion and/or metal cluster and an organic linker, and (b) passing a fluid stream comprising a mixture of hydrocarbons over the MOF to cause separation of the hydrocarbons. Also disclosed herein is a method of separating alkanes comprising the steps of (a) providing a MOF comprising nickel as the metal ion and/or metal cluster and formic acid as the linker, and (b) passing a fluid stream comprising a mixture of alkanes over the MOF to cause separation of the alkanes.
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
C07C 7/12 - Purification, separation or stabilisation of hydrocarbons; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers
21.
RHIZOMUCOR MIEHEI LIPASE TOWARDS AMIDE BOND FORMATION FOR THE SYNTHESIS OF MEDIUM TO LONG CHAIN N-ACYL GLYCINES IN AQUEOUS MEDIA
Described herein are lipase variants of a Rhizomucor Miehei Lipase. The lipase variants may be used to prepare medium to long chain N-acyl glcyines. The variants may have a parent sequence of SEQ ID NO: 3; and a D156 substitution and/or a L258 substitution, wherein the D156 substitution is selected from the group consisting of serine (S), glycine (G), glutamic acid (E), and threonine (T), wherein if the D156 substitution is glycine, the lipase variant comprises at least one other substitution, and the L258 substitution is selected from the group consisting of lysine (K), arginine (R), glutamine (Q), asparagine (N), histidine (H), and serine (S). The variants may have a parent sequence of SEQ ID NO: 3; and at least one substitution of the following amino acids: D156, L258. L267, V254, L255, N264, T265, S83, S84, W88, R30, R86, S56, L58, and 1I59.
There is provided a material comprising a plurality of geminal metal atom pairs supported on a polymeric carrier, and a method of preparing said material. In a particular embodiment, the material comprises a plurality of copper atom pairs supported on a polymeric carbon nitride (PCN) carrier. There is also provided a catalyst comprising said material, and a method of catalyzing coupling reactions.
The present invention relates to live attenuated flaviviruses and immunogenic composition of flaviviruses. The disclosure specifically relates to live attenuated Dengue- 1, Dengue-2, Dengue-3, and Dengue-4 viruses comprising 11 14T mutation in NS2B wherein the viruses have an increased immunogenicity, an increased rate of replication and decreased plaque size as compared to the wildtype viruses. It further discloses the generation of attenuated flaviviruses comprising NS2B- 11 14T with a mutation in amino acid 29 in prM and/or a mutation in amino acid 53 in NS1. It also relates to the use of said viruses for treatment of flavivirus infection.
The present invention relates to an engineered disulphide-linked ferritin assembly comprising at least one modified ferritin subunit, wherein the at least one modified ferritin subunit comprises the amino acid sequence set forth in SEQ ID NO: 1, and comprises; i) a F116H substitution, and zero or more amino acid substitutions at one or more positions selected from the group comprising E65, E128, E131, and D138 of SEQ ID NO: 1, and ii) a Cys substitution at two or more positions selected from the group comprising G37, L53, R66, G67, A74, A117 and A152 of SEQ ID NO: 1. The present invention also relates to its uses and manufacture.
The present invention describes a dishwasher handling apparatus (100). Dishware (10,11,12,13) made of non-magnetic material and equipped with a ferrous member (20) embedded or attached at a base, or a ferritic dishware (14) can be used with this apparatus. The apparatus (100) includes dishware handling apparatuses (101,101a,201) located upstream and downstream of a dishwasher (30). Each upstream or downstream dishware handling apparatuses (101,101a,201) include a conveyor elevator (130,230) that is operable to dock with a multi-storey shelf (110,210). Each of the multi-storey shelf has a level being equipped with a powered conveyor (120,220), on which vertical stacks (105) of dirty dishware are handled for cleaning or vertical stacks (107) of cleaned dishware are stored up after being cleaned. The upstream dishware handling apparatus (101a) further includes a rinsing robot (150). End-effectors (300,300-1,300-2,300-3) and handling robots (170,170a,180,280) are used to transfer dishware between component apparatuses or stations.
The present disclosure relates to a method of synthesising hexamethylenediamine and adipic acid. The method comprises homocoupling of acrylamide under conditions including using oxalic acid as a reductant and irradiating a reaction mixture comprising acrylamide with light from a light source to obtain an amide substrate, wherein the method further comprises a pathway 1 and a pathway 2 for forming hexamethylenediamine and adipic acid, respectively using the amide substrate.
C07C 2/74 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition with simultaneous hydrogenation
C07C 231/08 - Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
C07C 231/14 - Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
C07C 209/50 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
C07C 51/06 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid amides
Systems and methods for federated scoring by a plurality of nodes, wherein each node comprises sensitive data based on which a first set of scoring model coefficients generated. The first set of scoring model coefficients are broadcast to rest of the nodes and at least one node generates a federated scoring model based on the received contributory intermediate statistics and its respective first set of scoring model coefficients.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
The present disclosure describes delivery of nucleic acids to the central nervous system using extracellular vesicles, and in particular red blood cell extracellular vesicles.
A61P 25/00 - Drugs for disorders of the nervous system
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
123123133 in each motif are connected to form a cyclophane moiety. At least one of the two C-terminus residues is an aromatic residue. The present disclosure also concerns a method of producing the polypeptide.
Disclosed herein are methods of obtaining ferulic acid. In one aspect, the present disclosure refers to a method of hydrolysing oryzanol to obtain ferulic acid, wherein the method comprises: i. hydrolysing an oryzanol-comprising material in a first hydrolysis step; and ii. exposing product of i. to a second hydrolysis step; wherein the first hydrolysis step is enzymatic, and the second hydrolysis step is chemical.
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07J 13/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17
2222222222 and the host framework via multiple host−guest interactions. This work not only represents a new avenue for the construction of low-cost COFs but also expands the variety of the COF family using natural biochemicals as building blocks for broad application.
C08G 79/08 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon a linkage containing boron
B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
The present disclosure concerns a method of promoting the ubiquitination of MK2 protein, comprising contacting the MK2 protein with a compound of Formula (I) or a salt, solvate, stereoisomer or prodrug thereof. The present disclosure also concerns compounds of Formula (I) and their use in treating a disease or condition associated with MK2 protein.
C07D 307/38 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 11/00 - Drugs for disorders of the respiratory system
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
There are provided a composition and a method of preparing the composition. The composition comprises a composite powder material and an elastomer, wherein the composite powder material comprises a) tourmaline particles, b) rare-earth mineral particles, c) silicate mineral particles, d) metal oxide particles, and e) a binder, and wherein the sizes of the a), b), c) and d) are 5 pm or less. There are also provided an article and a method of preparing an article. There are further provided methods of using and uses of the article in the form of catheters, particularly urinary catheters.
Microfluidic devices and method of fabricating the microfluidic devices are provided. The microfluidic device (10) includes a base layer (100), a first layer (200) disposed on the base layer (100) and a second layer (300) disposed on the first layer (200). The first layer (200) defines one or more cell culture chambers (210). Each of the one or more cell culture chambers (210) configured to contain one or more cells. The second layer defines one or more air chambers (310). Each of the one or more air chambers (310) is adjacent a respective cell culture chamber (210). The microfluidic device allows the culture of single or multiple human-derived or animal-derived cells, or their co-culture with microorganisms under static or dynamic culture conditions.
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
Inventor
Goh, Xu Jie, Luke
Loh, Yue Xuan, Chantel
Bourguignon, Hugo, Jean Guillaume
Shen, Fang Yu, Tracy
Lau, Jo Hanan
Yen, Ching Chiuan
Foong, Kelvin, Weng Chiong
Leo, Sze Yin
Abstract
Disclosed is a method for fabricating an artificial jaw member. The method includes 3D printing a simulated jawbone such that the simulated jawbone comprises an inner material, outer shell at least partially encasing the inner material, and one or more tooth recesses, the outer shell being harder than the inner material, forming a sensor in each said tooth recess and an output connector in electrical communication with each said sensor, and providing a tooth in each said tooth recess.
PRODUCTION OF ENANTIOPURE ALCOHOLS, AMINES AND ACIDS FROM RACEMIC EPOXIDES BY CASCADE BIOTRANSFORMATION INVOLVING EPOXIDE ISOMERIZATION AND DYNAMIC KINETIC RESOLUTION
Disclosed herein is a method of producing an enantiomerically pure or enantiomerically enriched alcohol, acid or amine from a racemic 2-alkyl-3-phenyl oxirane or derivative thereof and/or a racemic 2-alkyl-2-phenyl oxirane or derivative thereof using at least two enzymes, which method comprises subjecting the 2-alkyl-3-phenyl oxirane or derivative thereof and/or the 2-alkyl-2-phenyl oxirane or derivative thereof to at least two enzyme-catalyzed chemical transformations in a one-pot reaction system.
The present invention generally relates to the provision of a conditioned medium comprising magnetically-induced cell secretome, the methods of producing the same, and a system for 5 the production of said conditioned medium. More particularly, the present invention provides an improved method of producing a conditioned medium comprising cell secretome induced by a directionally-specific pulsing electromagnetic field (PEMF), wherein the conditioned medium of the present invention is capable of enhancing proliferation, differentiation, survival or senescence of recipient cells. Also provided are a system for the production of said 10 PEMF-conditioned medium and the improved conditioned medium thereof, suitable for use in medical and commercial applications.
A61N 2/04 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets using variable fields, e.g. low frequency or pulsating fields
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
The present disclosure generally relates to a dosimeter assembly. In particular, the dosimeter assembly disclosed herein may be useful for monitoring gastric motility and pH as well as for detecting a radiation dose in a subject.
Design and fabrication method for a novel silicon-waveguide-integrated avalanche photodiode (APD) (100) is provided. Herein, an epitaxially grown APD device (95) comprises an absorption layer (35) of InGaAs and a multiplication layer (65) of InAlAs or certain other III-V compounds. Light propagating along a silicon-waveguide (80) is evanescently absorbed by the absorption layer (35) that is bonded on a silicon layer (15) and is optically coupled to the silicon-waveguide (80). Negligible variation is induced by the bonding process. This integrated APD (100) exhibits a high responsivity of substantially 0.99 A/W at substantially 1570 nm, a dark current (Idark) of substantially 7.6 nA at substantially 90% breakdown voltage (Vbr), and a maximum gain of substantially larger than 70. Integrating this novel APD (100) with silicon photonics and silicon CMOS could enable large-scale on-chip optical communication and computing with miniaturized size, as well as high operation speed with low parasitics.
G02B 6/12 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
42.
MAGNETOMETER AND A METHOD FOR MEASURING VECTOR COMPONENTS OF A MAGNETIC FIELD USING THE MAGNETOMETER
A magnetometer for measuring vector components of a magnetic field is described in an embodiment. The magnetometer comprising: a first section comprising a first magnetic layer; and a second section comprising a second magnetic layer, the second section being in-plane with and at an angle to the first section and is electrically connected to the first section. The first magnetic layer and the second magnetic layer each has a perpendicular magnetic anisotropy with near zero hysteresis, and are adapted to generate a first and second anomalous Hall voltage, respectively, in response to oscillatory spin-orbit torques generated in the respective magnetic layer and the magnetic field. The oscillatory spin-orbit torques are generated in response to an alternating current passing through the first magnetic layer and the second magnetic layer. The first anomalous Hall voltage includes a first second-harmonic Hall voltage associated with a first in-plane vector component of the magnetic field and the second anomalous Hall voltage includes a second second-harmonic Hall voltage associated with a second in-plane vector component of the magnetic field. The first in-plane vector component being in-plane with and at the angle to the second in-plane vector component. The first anomalous Hall voltage or the second anomalous Hall voltage includes a first-harmonic Hall voltage associated with an out-of-plane vector component of the magnetic field. A method for measuring vector components of a magnetic field using the magnetometer is also described.
An imager pixel comprising a forward-biased photo-detector with readout transistor for light-to-current conversion, and a ratiometric readout system comprising a current to pulse width converter. The readout system operates in a light mode to: generate a first current proportional to a photodetector current and a leakage current, on exposure to a photodetector voltage; and convert the first current to a first pulse width; and operates in a least significant bit (LSB) mode to: generate a second current proportional to a least significant bit (LSB) current and the leakage current, on exposure to a gate-source voltage; and convert the second current to a second pulse width. The system includes a converter circuit for converting the first pulse width to a count (CNTB) and the second pulse width to a count (CNTA), and a counting circuit for providing a radiometric readout based on a ratio of CNTB to CNTA.
The invention provides a composite actuator suitable for soft robotics that performs motions which include any one of bending, twisting, and extending, or a combination thereof. The composite actuator comprises a bladder, and a skin that covers the bladder. The skin has an overall Young's modulus that is larger than that of the bladder for acting as a deformation- controlling constraint so that motions are performed by the composite actuator during inflation or pressurisation of the bladder. The skin comprises one or more layers, with at least one layer being anisotropic in terms of having a minimum Young's modulus in a first direction and a maximum Young's modulus in a second direction that is orthogonal to the first direction, wherein the skin layer substantially envelops the bladder while being stretched along the first direction.
F15B 15/10 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
F15B 7/06 - Fluid-pressure actuator systems in which the movement produced is definitely related to the output of a volumetric pump; Telemotors - Details
F15B 15/00 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith
B25J 11/00 - Manipulators not otherwise provided for
The invention provides a seamless chamber actuator (100,100a,100b) which comprises a base layer (110,110a), a second layer (150,150a) and a substantially zero-volume actuation chamber (108) formed between the base and the second layers. In another embodiment, a torsion housing (220) is mounted on the seamless chamber actuator (100b) to provide a jamming actuator (200). The jamming actuator (200) is further configured with a glove to provide a wrist jamming actuator (200a). In another embodiment, a bending actuator (300) is formed by a base layer (310), a flat groove, a perforated membrane (330), a corrugated layer (350) and a substantially zero-volume actuation chamber (308,308a) is formed between the base and the corrugated layers. These seamless chamber actuators (100,100a,100b), jamming actuators (200,200a) or bending actuators (300) can be configured for force feedback, haptic sensation, force assistive or force resistive devices, such as, in VR, AR or body rehabilitation.
F15B 15/10 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
F15B 7/06 - Fluid-pressure actuator systems in which the movement produced is definitely related to the output of a volumetric pump; Telemotors - Details
B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
F15B 15/00 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith
B25J 11/00 - Manipulators not otherwise provided for
Disclosed is an impedance monitoring system for detection of attacks on a secure system. The impedance monitoring system comprises a perturbation current generator (PCG), a voltage sensing ring oscillator (VSRO), and a controller. The PCG generates a perturbation current to excite a supply impedance of the secure system and the controller counts oscillations in the VSRO, resulting from voltage changes in the secure system, to detect an attack. In particular, the controller detects an attack by capturing a reference VSRO count, capturing a subsequent VSRO count for a non-zero perturbation current, and normalising the subsequent VSRO count based on the reference VSRO count.
G06F 21/72 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information in cryptographic circuits
G01R 27/16 - Measuring impedance of element or network through which a current is passing from another source, e.g. cable, power line
47.
DETECTOR SCHEME FOR DETECTING LASER VOLTAGE PROBING ATTACKS
Disclosed is a sensor fabric for detecting an attack on transistors. The fabric includes a plurality of sensor clusters. Each sensor cluster comprises a plurality of photodetectors and transistors, each photodetector being disposed next to a respective said transistor, a standard cell and an aggregator. The standard cell comprising a thresholding comparator for comparing a first input from a first group of the photodetectors of the respective cluster and a second input from a second group of the photodetectors of the respective cluster, the first input and second input being proportional to incident light sensed by the respective photodetectors, and flipping an output of the standard cell if a difference between the first input and second input exceeds a predetermined threshold. The aggregator aggregates the outputs from the clusters to produce an aggregated output, and triggering an alarm on detection of an attack based on the aggregated output.
G06F 21/71 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Tay, Zirui, Matthew
Lin, Weikang, Nicholas
Cheow, Lih Feng
Chen, Chia-Hung
Rénia, Laurent Claude Stéphane
Ng, Fong Poh, Lisa
Abstract
The present disclosure concerns a microfluidic method of assaying antibody secreting cells (ASCs), comprising the steps of isolating ASCs within droplets such that each droplet encapsulates only one ASC; iincubating the droplets of step a) to accumulate antibodies within the droplets; picoinjecting virus into the droplets of step b) to form immune complex droplets; picoinjecting host cells into the immune complex droplets to form neutralised droplets and infected droplets; and sorting the infected droplets from the neutralised droplets, based on infection of the host cells by the virus, to assay the ASCs within the neutralised droplets. The present disclosure also concerns a microfluidic platform thereof.
A computing circuit comprising a plurality of reconfigurable processing elements (PEs); data communication lines connecting an output port of each of the PEs with an input port of each other one of the PEs; wherein the computing circuit is configured to execute a data flow model by configuring at least a second subset of the plurality of PEs to perform a respective discrete computation implementing the data flow model; and wherein a first PE of the second subset of PEs is configured to perform its respective discrete computation on receipt of a ready to receive output signal from one or more destination PEs; wherein the one or more destination PEs are configured to perform a computation on the output of the first PE according to the data flow model.
G06F 15/82 - Architectures of general purpose stored program computers data or demand driven
G06F 9/38 - Concurrent instruction execution, e.g. pipeline, look ahead
G06F 7/57 - Arithmetic logic units [ALU], i.e. arrangements or devices for performing two or more of the operations covered by groups or for performing logical operations
Systems and methods for integration of SRT datasets by receiving raw SRT datasets obtained from a plurality of tissue sample, performing dimension reduction on the plurality of SRT datasets by a dimension reduction model, performing spatial clustering of the plurality of SRT datasets based on a clustering model, wherein the dimension reduction and spatial clustering are performed in parallel to determine an integrated SRT representation of the plurality of tissue samples.
The present invention describes an adaptive learning and training system (100,100a) and method (200) offered at an institution (10,10a,10b,etc.). The institution has 3 databases: a users database (126), a learning content database (122) and a training content database (124). A learning and training software application (130), linked to the databases, includes 3 modules: a Content Classification and Context Prediction module (150), an Adaptive Learning module (170) and a Skill Level module (190). The Adaptive Learning module (170) includes a Machine Learning Recommender (172) and an AI instructor (174). The module (150) classifies the learning contents and training contents into topics/subtopics, required skill levels and mandatory frequencies. In use, the ML Recommender (172) recommends a topic/subtopic of a skill level proximal to a user's course ID. User response is assessed in the module (190) by a new skill score; the new skill score may be modulated by time elapsed between learning/training sessions.
G09B 7/02 - Electrically-operated teaching apparatus or devices working with questions and answers of the type wherein the student is expected to construct an answer to the question which is presented or wherein the machine gives an answer to the question presented by the student
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
Inventor
Panengad, Pradeep Paul
Unniyampurath, Unnikrishnan
Wang, Linfa
Dharmaraj, Rajesh Babu
Nambiar, Ajay Purushothaman
Anantharajan, Senthil Kumar
Naduparambil, Manoj Krishnan
Abstract
A device for debriding tissue is described. In an embodiment, the device comprises an electrolysis unit 300 having two electrodes 306, 310. The electrolysis unit 300 is configured to receive an electrolyte for electrically connecting the two electrodes 306, 310. The two electrodes 306, 310 are adapted to connect to a power supply 314 to receive an electric current for electrolysis of the electrolyte, where in use, one of the two electrodes 306, 310 is adapted to provide an acidic region or an alkaline region to the tissue during electrolysis of the electrolyte for debriding the tissue. A method for debriding tissue using the aforementioned device is also described.
Disclosed herein is a method of recycling a spent battery material, the method comprising the steps of (a) providing a first reaction compartment fluidly connected to a cathode side of an electrolyser, (b) in a second reaction compartment, LiOH is added to precipitate the Co2+to provide a filtered alkaline electrolyte solution which is supplied to a third reaction compartment when the Co2+44 and accepts the filtered alkaline electrolyte solution from the second reaction compartment, the reaction loops are continued until the Li+ ions are substantially or are entirely removed from the electrolyte. Also disclosed herein are an electrolytic device comprising an electrolyser, a first to third cathode tank, and an anode tank, and an electrolytic device comprising a first electrolyser, and a second electrolyser.
The present disclosure concerns a method of extracting platinum group metals (PGM) from a material, the method comprising surface oxidising the material; ultrasonicating the surface oxidised material of step a) in the presence of an acid; and bioleaching the ultrasonicated material in the presence of cyanide in order to form a leachate comprising PGM, the cyanide being formed from a cyanide producing microbe in the presence of a cyanide precursor.
The present disclosure concerns a light field detector for converting a vector of an 5 electromagnetic radiation into a chromatic output, comprising at least one azimuth detector on a transparent substrate and the at least one azimuth detector comprising at least two luminescent nanocrystal pixels having different emission wavelengths relative to each other. The present disclosure also concerns a light field sensor comprising the light field detector thereof and methods of fabricating the light field 10 detector.
Disclosed is a waste management system for general waste stream (Cans, Paper, Plastic, non-recyclables). The system comprises an image capture device for capturing an image of a waste object of a user; at least one processor; and memory. The memory stores instructions that, when executed by the at least one processor, implement an inferencing pipeline for analysing the image to: identify a waste stream of the waste object; identify a specific type of the waste object; and if the waste object belongs to a recyclable waste category, assess acceptability of the waste object for recycling. Moreover, the system includes a display for displaying the specific type and acceptability to the user.
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
57.
MAGNETIC RESONANCE RELAXOMETRY (MRR) MEASUREMENT TO PREDICT CHONDROGENIC POTENTIAL OF MESENCHYMAL STEM CELLS (MSCS)
Chondrogenic potential of mesenchymal stem cells (MSCs) can be determined using magnetic resonance relaxometry by measuring T2 relaxation value of the MSCs.
G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
The present invention relates to an expression cassette comprising a Type III interferon gene, and a nitric oxide-inducible promoter operably linked to the Type III interferon gene. In an embodiment, the Type III interferon gene encodes human interferon L1 (IFNL1). The invention also relates to a genetically engineered bacterium comprising such an expression cassette, composition comprising the bacterium, and use of the expression cassette to produce recombinant Type III interferon.
nm2n+2–ppp, where n, m and p are integers, with the proviso that 1 ≤ (n+m)/p ≤ 8, and wherein the mixture of the deoxidizer solvent and the co-solvent comprises hydroxyl groups at a concentration in the range of 2 M to 20 M. There is also provided a method of forming the composition. There are also provided a method of forming a composition material and a device comprising the composite material.
B22F 1/107 - Metallic powder containing lubricating or binding agents; Metallic powder containing organic material containing organic material comprising solvents, e.g. for slip casting
The present invention relates to methods of rejuvenating aged oocytes using young somatic cells through the generation of chimeric follicles. The chimeric follicles defined herein may be used to treat infertility or improve fertility in female subjects.
A61P 15/08 - Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
61.
A GRAPHENE OXIDE-THERMORESPONSIVE POLYMER COMPOSITE FILM
A graphene oxide-thermoresponsive polymer composite film There is provided a two-dimensional (2D) graphene oxide-thermoresponsive polymer composite film comprising: at least two graphene oxide (GO) layers; and a thermoresponsive polymer layer between each GO layer, wherein the thermoresponsive polymer layer switches between being aligned and being disoriented between the at least two GO layers when temperature of the composite film changes from being below lower critical solution temperature (LCST) of the thermoresponsive polymer comprised in the composite film to being above the LCST of the thermoresponsive polymer. There is also provided a method of forming the composite film.
B32B 23/04 - Layered products essentially comprising cellulosic plastic substances comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
C02F 1/00 - Treatment of water, waste water, or sewage
62.
FORCE CONTROL MODULE AND WEARABLE DEVICE COMPRISING THE SAME
The present disclosure generally relates to a force control module (100) and a wearable device (200) comprising the same. The force control module (100) has a fixed part (110), a rotational part (120) aligned to the fixed part (110) and rotatable about a rotational axis of the fixed part (110), and an elastomeric part (130) within the fixed part (110) or rotational part (120). The elastomeric part (130) is separated from an inner surface (112/122) of the fixed part (110) or rotational part (120) and is coupled to the rotational part (120). The elastomeric part (130) is actuatable towards the inner surface (112/122) to generate a variable actuation force on the inner surface (112/122), the variable actuation force for resisting rotation of the rotational part (120).
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
F16D 51/08 - Brakes with outwardly-movable braking members co-operating with the inner surface of a drum or the like shaped as an expansible fluid-filled flexible member
B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
63.
SENSOR, SYSTEM AND METHOD FOR NON-CONTACT SENSING OF A PHYSIOLOGICAL PARAMETER OF A BODY
A sensor 104 for non-contact sensing of a physiological parameter of a body 102 is described. In an embodiment, the sensor 104 comprises: a waveguide, the waveguide comprises a metamaterial and is configured to receive a transmitted signal and to propagate the transmitted signal in a spoof surface plasmon mode along the waveguide to produce an evanescent electromagnetic field and to provide a received signal, wherein the waveguide is placed at a predetermined distance away from the body 102 for non-contact sensing of a perturbation produced by a physiological motion of the body 102 using the evanescent electromagnetic field, the perturbation produces a phase shift between the transmitted signal and the received signal for use in determining the physiological parameter of the body 102. A system 100 and a method 200 for non-contact sensing of a physiological parameter of a body 102 are also described.
A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
An apparatus for detecting heart rate at a member of a user, the apparatus comprising: at least one magnet; a retaining means to retain the at least one magnet in register to the member and apply a pre-calibrated pressure on the at least one magnet in relation to the member while allowing motion of the at least one magnet in response to pulsation in the member; a magnetic sensor configured to measure a change in a magnetic field in response to motion of the at least one magnet; one or more processors in communication with the magnetic sensor, the one or more processors configured to determine the heart rate at the member of the user based on a signal received from the magnetic sensor.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
65.
NEW NASICON-TYPE HIGH VOLTAGE SODIUM VANADIUM PHOSPHATES MATERIALS FOR NA-ION BATTERIES
In a described embodiment, a sensor array including a plurality of resistive elements arranged in a plurality of rows and columns is provided. A row driving unit is configured to connect a plurality of rows of the resistive elements of the sensor array to a voltage source for driving the voltage source to a row of the resistive elements. The row driving unit further includes switching units for performing a switching operation, row driving amplifiers, and feedback instrumentation amplifiers (FBIAs). Each of the switching units is selectively coupled to each of the row driving amplifiers and each of the row driving amplifiers is further coupled to each of the plurality of FBIAs. A column scanning unit for detecting a voltage signal of a resistive element includes column operational amplifiers. Each of the column operational amplifiers is further connected to a column of the sensor array.
G01D 5/16 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying resistance
An imaging system (10) is provided. The imaging system (10) includes a beamsplitter (12), a first optical arm (14), a second optical arm (16) and or more detectors (18) arranged to receive an image from the beamsplitter (12). The first optical arm (14) 5 includes a first objective lens (20), a first phase plate (22) and a first mirror (24). The first mirror (24) is arranged to direct emission from the first objective lens (20) through the first phase plate (22) towards the beamsplitter (12). The second optical arm (16) includes a second objective lens (26), a second phase plate (28) and a second mirror (30). The second mirror (30) is arranged to direct emission from the second objective lens (24) 0 through the second phase plate (28) towards the beamsplitter (12). The first and second objective lenses (20) and (26) are in an opposing relationship.
The present invention describes a horizontal directional soil coring and sampling apparatus and method. With this invention, a location of a desired soil sample (201, 301) is determined and a drill profile is plotted from an entrance pit (30). A drill head is driven along the drill profile by drill pipes (136) to create a pilot drill-path (140); the pilot drill-path (140) is then enlarged to a bored path (150) with a forward reamer (160). In one embodiment, a coring head (210) and a soil extractor (270) are driven into the bored path (150) to obtain an undisturbed soil sample (201). In another embodiment, outer tubes (336) are driven along the bored path (150) with a coring head (310), and a wireline soil extractor (370) is sent down an interior bore of the outer tubes to obtain an undisturbed soil sample (301).
An inversion-type ferroelectric capacitive memory (FCM) is disclosed. The memory comprises a semiconductor layer comprising a lightly doped region and a heavily doped region on the lightly doped region, a bottom electrode on the heavily doped region, a ferroelectric layer on both the heavily doped region and the lightly doped region, and a top electrode formed on the ferroelectric layer. Also disclosed is a FCM crossbar array comprising a plurality of the inversion-type FCMs, on silicon-on-insulator (SOI) substrates.
H01L 27/10 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including a plurality of individual components in a repetitive configuration
The invention relates generally to the field of nucleic acid detection. In particular, the specification teaches a method of detecting a polynucleotide analyte in a sample. In one aspect, the method comprises the use of a cleaving agent with flap endonuclease activity and a type V CRISPR/Cas effector protein. In another aspect, the type V CRISPR/Cas effector protein is a Cast 2 protein.
22xy'22O, wherein x is a number from 0 to 5; y is a number from 0 to 3; and z is a number from 0 to 10. The present disclosure also concerns a method of synthesising core-shell nanoparticles.
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 40/00 - Manufacture or treatment of nanostructures
This invention describes a data-driven bunker planner system (11) for optimising refuel costs for a marine vessel (1). The bunker planner system (11) operates on a computing system (10) located on the vessel (1) and includes a data acquisition module (111), a fuel-price forecasting module (112) and a data optimisation module (113). The fuel-price forecasting module (112) forecasts the future fuel prices and/or fuel indexes in the long-term or the short-term. The data optimisation module (113) determines an optimal time to fulfil a refuel term contract or combinations of contracts based on the forecasted fuel prices and/or fuel indexes. The forecasted fuel prices and/or fuel indexes, the optimised fuel term contracts and a bunkering plan are outputted through a notification generation module (114) and a human-machine interface system (18). The bunker planner system outputs have been verified using real-life data trained on various customized machine learning and optimization models.
G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
CSS-glycosides upon cross-coupling with suitable reagents. Further, the compound of Formula (I) is bench-stable therefore can be prepared on multi-gram scale and stored for a period of about a few weeks or months.
C07H 13/04 - Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
C07H 15/18 - Acyclic radicals, substituted by carbocyclic rings
C07H 17/00 - Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
C07H 17/02 - Heterocyclic radicals containing only nitrogen as ring hetero atoms
74.
METHOD FOR DETECTING HIGH-RISK NASOPHARYNGEAL CANCER
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapore)
Inventor
Tay, Kai Xun, Joshua
Loh, Kwok Seng
Teo, Wei Keat
Loh, Woei Shyang
Suryani, Luvita
Wu, Bingcheng
Abstract
The invention relates generally to the field of oncology. Provided herein is a method for predicting the likelihood of recurrence or prognosis of a cancer in a subject, comprising comparing the level of expression of one or more biomarkers selected from the group consisting of Fibroblast Growth Factor 2 (FGF2), Complement Component 3 (C3), and GTPase, IMAP Family Member 7 (GIMAP7) in a sample obtained from the subject to a reference. In particular, the cancer is nasopharyngeal cancer. Also provided is a composition or solid support comprising a plurality of DNA/RNA complexes, wherein each DNA/mRNA complex in the plurality comprises a biomarker and a first and second DNA probe hybridized to the biomarker, wherein the plurality of DNA/mRNA complexes comprise one or more biomarkers selected from the group consisting of FGF2, C3, and GIMAP7.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Hong, Jing Han
Tan, Jing
Teh, Bin Tean
Abstract
Disclosed herein a method of treating a BAP1 -related tumour in a subject, the method comprising determining whether BAP1 in the sample is functional or non-functional, and administering to the subject a therapeutically effective amount of a PARP inhibitor and a LSD1 inhibitor if BAP1 in the sample is non-functional. Also disclosed herein is a method screening and identifying an anti-proliferative compound, the method comprising obtaining a population of BAP1-deficient cells, treating said BAP1 -deficient cell population with the anti-proliferative compound, and determining a change in proliferative activity of the population of BAP1 -deficient cells compared to a population of cells producing functional BAP1 protein.
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/502 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
A photodetector comprising at least one geometrically arranged plasmonic nanostructures array, the plasmonic nanostructures array comprising nanostructures on a substrate, the substrate comprising one of: a graphene sheet and or one or more graphene ribbons, the at least one plasmonic nanostructures array being symmetrically arranged to realize a build-up in electrical response to circularly polarized light (CPL) incident on the photodetector; and at least two electrodes connected to the at least one geometrically arranged plasmonic nanostructures array to enable a readout of the electrical response to CPL incident on the photodetector.
Disclosed herein is a method for producing an enantiomerically pure or enantiomerically enriched 2(R)- or 2(S)-phenylalkanal or a derivative thereof from trans-1-phenylalkene oxide or a derivative thereof using one or more recombinant microbial cells genetically engineered to overexpress an isomerase enzyme, a cell-free extract comprising the isomerase enzyme, a medium comprising a purified isomerase enzyme or a medium comprising an immobilized isomerase enzyme, wherein the transformation of the trans-1-phenylalkene oxide or a derivative thereof to 2(R)- or 2(S)-phenylalkanal or a derivative thereof involves a 1,2-alkyl shift reaction.
C12P 39/00 - Processes involving microorganisms of different genera in the same process, simultaneously
C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymes; General processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
C07B 41/00 - Formation or introduction of functional groups containing oxygen
Disclosed herein are a metal-air fuel cell metal source material, a composite material comprising a metal selected from an alkali metal, an alkaline earth metal, aluminium, zinc, or iron, a conductive carbon material, and a binder, a redox-mediated metal-air fuel cell cartridge comprising a cartridge housing, and a composite material comprising a metal selected from an alkali metal, an alkaline earth metal, aluminium, zinc, or iron, a conductive carbon material, and a binder, and a redox-mediated metal-air fuel cell system comprising a redox flow cell and a first tank suitable to house an anolyte and a redox-mediated metal-air fuel cell cartridge. Also disclosed herein is a method of feeding a metal in a redox-mediated metal-air fuel cell system.
Apparatus for characterization of photovoltaic modules and spectral responsivity testing tools are described. An apparatus for characterization of photovoltaic modules comprises: a solar tracker configured to support a photovoltaic module under test and to orientate the photovoltaic module under test to be normal to a solar radiation direction; a monitoring system configured to be electrically coupled to the photovoltaic module under test and monitor an electrical output of the photovoltaic module under test; a reference solar cell arranged on the solar tracker and configured to measure incident solar radiation; an enclosure surrounding the solar tracker and the reference solar cell, the enclosure comprising a retractable cover movable between a closed position and an open position, wherein, when the apparatus is in use, in the closed position the photovoltaic module under test is covered by the retractable cover and in the open position, the photovoltaic module under test is directly exposed to solar radiation.
Systems, methods, and devices predict pharmacokinetic parameters following administration of a formulation, such as a medium-chain triglyceride (MCT). The method includes generating training data indicating human metabolism outcomes of the formulation. The training data includes stomach emptying parameters, a digestion rate, an absorption constant, or a conversion rate with a training target variable being ketone concentration or plasma free fatty acid concentration. The method also includes training a physiologically based biopharmaceutics (PBB) model with the training data and using the PBB model to predict, using the patient data, at least one of a target plasma free fatty acid concentration or a target ketone concentration. Furthermore, as part of a parameter sensitivity analysis of the PBB model, the method varies input parameters of the training data against a simulated mean plasma free fatty acid profile or a simulated mean ketone plasma profile.
A photonic device comprising: one or more electrodes configured for voltage application to manipulate an electric field; a ferroelectric material electrically polarizable into a plurality of states through the manipulation of the electric field across the ferroelectric material, wherein each of the plurality of states is held in the ferroelectric material non-volatilely even after removal of the voltage applied to the one or more electrodes; and a waveguide in contact with the ferroelectric material such that the refractive index of waveguide is changeable according to the state held in the ferroelectric material.
G02F 1/05 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect with ferro-electric properties
H10B 69/00 - Erasable-and-programmable ROM [EPROM] devices not provided for in groups , e.g. ultraviolet erasable-and-programmable ROM [UVEPROM] devices
G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using ferroelectric elements
82.
A METAL ELECTRODE SYSTEM FOR ELECTROCHEMICAL CELLS
Provided herein is a redox flow battery, comprising: a catholyte compartment, comprising a catholyte, and a cathode; an anolyte compartment, comprising an anolyte, and an anode comprising a first metal; and an ion selective membrane disposed between the cathode compartment and anode compartment, wherein: the first metal is selected from the group consisting of an alkali metal, an alkaline earth metal, a Group III metal, and a transition metal; the anolyte comprises an anodic redox mediator; and the anodic redox mediator has a redox potential versus a standard hydrogen electrode that is more positive than a redox potential of the first metal versus a standard hydrogen electrode.
The present invention describes heat sinks (100) in which fins (120) are hybrid 3D printed using laser powder-bed fusing (LPBF) or selective laser melting (SLM) (200) of a fin powder (122) deposited directly over a substrate (140). The fin powder (122) forms a powder-bed, which height is increased, layer by layer, and the fins (120) are being built up, layer by layer, by laser melting and fusing the fin powder (122). The fin powder (122) may be copper, copper alloy, aluminium or aluminium alloy, whilst the associated substrate (140) is copper- based or aluminium-based. The substrate (140) is prepared by conventional machining, hence, the process (200) is called hybrid LPBF or SLM. The heat sinks (100) obtained have excellent heat dissipation and temperature stability performances.
Disclosed is a verifiable ledger database configured to manage transactions of a ledger, comprising a plurality of shards formed by partitioning transaction data. Each shard comprises a ledger storage configured to provide access to the transaction data and support a plurality of proofs, a transaction manager configured to execute each transaction according to a respective transaction request, and a verifier configured to verify the transactions by returning the proofs according to verification requests.
G06F 16/27 - Replication, distribution or synchronisation of data between databases or within a distributed database system; Distributed database system architectures therefor
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
G06F 16/22 - Indexing; Data structures therefor; Storage structures
85.
ARTS MIMETIC COMPONDS AND COMBINATIONS THEREOF FOR TREATING HIGH-RISK NEUROBLASTOMA
CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (Israel)
SINGAPORE HEALTH SERVICES PTE LTD (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Larisch, Sarit
Loh Hong Pheng, Amos
Chen, Zhi Xiong
Abstract
The present disclosure provides apoptosis related protein in the TGF-beta signaling pathway (ARTS) mimetic compounds, compositions and uses thereof for treating neoplastic disorders affecting the neural system and/or neural cell in a subject in need thereof, specifically neuroblastoma. The present disclosure further provides combined compositions of these ARTS mimetic compounds.
C07C 233/56 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A device for weight adjustment in an optical neural network is provided. The device includes a first waveguide configured to receive and transmit an input optical signal. The input optical signal is defined by an amplitude and a first wavelength. The device further includes an optical resonator in optical communication with the first waveguide. The optical resonator has a first refractive index and is defined by a first resonance frequency. The amplitude of the input optical signal is modulated by the optical resonator based on the first resonance frequency to obtain a first weighted input optical signal. The device further includes a second waveguide optically coupled with the optical resonator. The second waveguide is configured to transmit a backpropagation optical signal that is defined by a second wavelength. The backpropagation optical signal is partially coupled into the optical resonator to adjust the first resonance frequency to a second resonance frequency. An amplitude of a subsequent input optical signal is modulated by the optical resonator based on the second resonance frequency to obtain a second weighted input optical signal.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
G02B 6/12 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
The present disclosure relates to methods for measuring length of a nucleotide sequence including DNA sequence, particularly for measuring length of a telomere.
Disclosed are vesicle-based compositions and uses thereof. The composition comprising a vesicle, such as a red blood cell-derived extracellular vesicle (RBCEV), for delivery of a retinoic acid inducible gene I receptor (RIG-I) agonist to a cell. Also disclosed are methods for treating diseases by administering the vesicle-based compositions.
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
The precise molecular sieving architectures with Janus-like characteristics via an interpenetrating polymer network combining the hydrophilic cPI polymer and hydrophobic microporous covalent organic framework (COF) exhibit super-high permeances for both polar and nonpolar solvents. A unidirectional diffusion and convection process significantly speeds up chemically stable COFs with uniform and tailorable channels growing on polymeric hollow fibre that can efficiently separate organic solvents under ultrafiltration conditions.
Disclosed is a multi-layer contact structure comprising a semiconductor substrate, a terminal electrode, and a contact layer structure. The contact layer structure comprises a metal-containing carrier selective (MCS) layer, the contact layer structure being in intimate contact with the semiconductor substrate and the terminal electrode.
Various embodiments may relate to a laser device. The laser device may include a lattice structure defining a first laser cavity and a second laser cavity. The first laser cavity may be optically coupled to the second laser cavity via an asymmetric coupling. The laser device may be configured to switch to a single mode regime when a pump power exceeding a threshold is applied to the lattice structure.
The invention relates to a yeast-based probiotic alcoholic beverage comprising probiotic yeast, wherein the probiotic yeast has a cell count of > 5 log CFU/mL after 100 days of storage at 30°C. The invention further relates to a method of forming the yeast-based probiotic alcoholic beverage comprising the steps of adding a first yeast to a wort or must followed by fermentation of the wort or must at a first pre-determined period of time and at a first pre-determined temperature to form an alcoholic beverage, and adding a second yeast to the alcoholic beverage to form a yeast-based probiotic alcoholic beverage, wherein the second yeast is a probiotic yeast.
The invention relates to a probiotic alcoholic beverage comprising microencapsulated probiotics, wherein after storage of the beverage at a predetermined temperature for a predetermined time, the microencapsulated probiotics have a cell count of > 5.0 log CFU/mL, wherein the predetermined temperature is 20-30°C and the predetermined time is > 7 days. In one embodiment, the microencapsulated probiotics are in the form of microencapsulated beads. The invention further relates to a method of forming the probiotic alcoholic beverage.
There is provided a method of profiling a microbiotic composition of a sample comprising the nucleic acid molecules of the microbiotic composition, the method comprising a) partitioning the sample in a sufficient number of partitions such that at least a portion of the partitions comprises no more than one nucleic acid molecule of the microbiotic composition; b) contacting the partitions of the sample to a plurality of mismatch-tolerant probes that are capable of binding to the nucleic acid molecules or parts thereof under suitable conditions; c) determining signals generated by each of the plurality of mismatch-tolerant probes in each partition; and d) establishing the microbiotic composition in the sample based on the signals. Also disclosed is a method of determining a health and kits for uses in the methods as described herein.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
A device for counteracting side-channel attacks (SCA), including a machine learning unit (MLU) that is connectable to a cryptographic core. The MLU includes: a feature extractor unit configured to extract selected information-sensitive signals from the cryptographic core and to generate machine learning features based on the selected information-sensitive signals; and a machine learning-based power estimator unit configured to output cumulative information-sensitive energy based on the generated machine learning features. The device further includes a power compensation unit that is configured to cancel out the cumulative information-sensitive energy so as to counteract side-channel attacks (SCA).
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
G05F 1/565 - Regulating voltage or current wherein the variable actually regulated by the final control device is dc using semiconductor devices in series with the load as final control devices sensing a condition of the system or its load in addition to means responsive to deviations in the output of the system, e.g. current, voltage, power factor
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapore)
NATIONAL UNIVERSITY OF SINGAPORE (Singapore)
Inventor
Chew, Wei Leong
Keng, Choong Tat
Chu, Jang Hann
Yogarajah, Thinesshwary
Abstract
The present invention relates generally to the field of molecular biology. In particular, the specification teaches methods of preventing or treating an RNA viral infection in a subject, comprising administering at a dose of 5x1011 to 5x1013 vgs/kg of a recombinant adeno-associated virus (AAV) to the subject, wherein the AAV comprises at least one heterologous nucleic acid sequence encoding a Cast 3 nuclease and one or more guide RNAs. In one embodiment, the RNA virus infection is an infection by Enterovirus 71.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Hard masks and methods of forming hard masks are described. The hard mask has an average roughness less than 10 nm and a modulus greater than or equal to 400 GPa. The method comprises exposing a substrate to a deposition gas comprising a dopant gas or a precursor (solid (e.g. Alkylborane compounds) or liquid (e.g. Borazine)), a carbon gas and argon at a temperature less than or equal to 550 C, and igniting a plasma from the deposition gas to form an ultrananocrystalline diamond film having an average roughness less than 10 nm and a modulus greater than or equal to 400 GPa.
C23C 16/511 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating using electric discharges using microwave discharges
99.
POLYMER COMPOSITES FOR HARVESTING MOISTURE AND METHODS OF FABRICATION THEREOF
The present disclosure concerns polymer composites for harvesting moisture and their uses thereof. The polymer composite comprises a hydrophilic polymer network and a hygroscopic salt intercalated within the polymer network. The weight ratio of the polymer network to the salt is about 0.1:1 to about 15:1. The present disclosure also concerns methods of fabricating the polymer composites.
B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
A01G 24/35 - Growth substrates; Culture media; Apparatus or methods therefor based on or containing synthetic organic compounds containing water-absorbing polymers
A01G 24/10 - Growth substrates; Culture media; Apparatus or methods therefor based on or containing inorganic material
C08K 3/01 - Use of inorganic substances as compounding ingredients characterised by their specific function
B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
The invention relates generally to the field of genome editing. In particular, the specification teaches a prime editor polypeptide that is capable of carrying out prime editing in the presence of a prime editing guide RNA (pegRNA). The prime editor comprising a nucleic acid programmable DNA binding protein connected to a reverse transcriptase polypeptide, wherein the reverse transcriptase polypeptide is modified to lack RNase H activity.
patents
