National University Corporation Hokkaido University

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G02B 6/02 - Optical fibres with cladding 16
G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers 14
A61K 9/127 - Liposomes 13
B01J 37/02 - Impregnation, coating or precipitation 11
A61K 9/00 - Medicinal preparations characterised by special physical form 9
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1.

TREATED CELL MATERIAL USED IN BIOLOGICAL TISSUE REPAIR

      
Application Number 18684928
Status Pending
Filing Date 2022-08-24
First Publication Date 2024-10-24
Owner
  • MOCHIDA PHARMACEUTICAL CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • KONAN GAKUEN (Japan)
Inventor
  • Iwasaki, Norimasa
  • Onodera, Tomohiro
  • Yamaguchi, Jun
  • Nagahama, Koji
  • Saito, Mitsuru

Abstract

It is desirable to provide a novel biomaterial and the like for tendon repair. Provided is a biomaterial for tendon repair containing a hydrogel formed by means of a cross-linking reaction between a reactive group A and a reactive group B, wherein the hydrogel contains a water-soluble polymer having the reactive group A, and mesenchymal stem cells having the reactive group B.

IPC Classes  ?

2.

CALIBRATION METHOD FOR PHASE MODULATOR, CALIBRATION METHOD FOR BALANCED PHOTODETECTOR, AND CALIBRATION SYSTEM FOR PHASE MODULATOR

      
Application Number 18579627
Status Pending
Filing Date 2022-07-19
First Publication Date 2024-10-10
Owner
  • National Institute of Information and Communications Technology (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Fujiwara, Mikio
  • Takeoka, Masahiro
  • Sasaki, Masahide
  • Tomita, Akihisa

Abstract

A phase modulator calibration method includes steps of: providing a first delay interferometer to be used as a phase calibration reference and a second delay interferometer in which a phase modulator to be calibrated is installed in an optical path; for each of the first and second delay interferometers, measuring a delay time based on a time interval between pulses split from one input pulse and synchronizing the delay time with a cycle of a transmission clock; for the first delay interferometer, adjusting a phase difference so that input continuous-wave laser light produces an intensity-enhancing interference at an output; and determining the control signal with a calibration circuitry formed by connecting the first delay interferometer as a front stage and the second delay interferometer as a rear stage in a cascaded manner.

IPC Classes  ?

  • G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
  • G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour by interference

3.

SULFIDE SOLID ELECTROLYTE

      
Application Number 18578874
Status Pending
Filing Date 2022-07-14
First Publication Date 2024-10-03
Owner
  • IDEMITSU KOSAN CO.,LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Terai, Kota
  • Utsuno, Futoshi
  • Higuchi, Hiroyuki
  • Tadanaga, Kiyoharu
  • Miura, Akira
  • Rosero Navarro, Nataly Carolina

Abstract

Provided is a sulfide solid electrolyte that has a novel crystal structure and exhibits an ionic conductivity, the sulfide solid electrolyte containing a lithium atom, a phosphorus atom, a sulfur atom, and at least one kind of halogen atom selected from a chlorine atom and a bromine atom, and having a specific diffraction peak in powdery X-ray diffractometry using CuKα line, and a method for producing a sulfide solid electrolyte, the method including mixing a solvent 1 having a heteroatom and a raw material 1 containing specific atoms to prepare a mixture, preparing a solution that contains a raw material 2 containing a halogen atom and a solvent 2 having a heteroatom, mixing the mixture and the solution to prepare a fluid, and heating the fluid.

IPC Classes  ?

4.

LIGNIN-DEGRADING CATALYST, METHOD FOR MANUFACTURING SAME, METHOD FOR DEGRADING LIGNIN, AND METHOD FOR REGENERATING LIGNIN-DEGRADING CATALYST

      
Application Number 18260488
Status Pending
Filing Date 2021-12-27
First Publication Date 2024-09-12
Owner
  • HIROSAKI UNIVERSITY (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Yoshida, Akihiro
  • Sonoki, Tomonori
  • Irwan, Kurnia
  • Guan, Guoqing
  • Abudula, Abuliti
  • Masuda, Takao
  • Yoshikawa, Takuya

Abstract

Provided are a lignin degradation catalyst that exhibits excellent lignin degradability and that is readily separated after degradation reaction, a method for producing the catalyst, and a method for degrading lignin. The lignin degradation catalyst according to the present invention contains a substrate and at least one metal compound immobilized on the substrate, wherein the at least one metal compound contains a copper compound. The method for producing a lignin degradation catalyst according to the present invention includes the step of brining a porous copper substrate into contact with a solution containing an oxidant to obtain a substrate having a copper compound immobilized thereon, or the step of subjecting a porous copper substrate to electro-oxidation to obtain a substrate having a copper compound immobilized thereon.

IPC Classes  ?

  • B01J 23/889 - Manganese, technetium or rhenium
  • B01J 23/72 - Copper
  • B01J 23/755 - Nickel
  • B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
  • B01J 23/94 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides of the iron group metals or copper
  • B01J 35/56 - Foraminous structures having flow-through passages or channels, e.g. grids or three-dimensional monoliths
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
  • B01J 38/02 - Heat treatment
  • C07C 41/01 - Preparation of ethers
  • C07C 45/32 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with molecular oxygen
  • C07C 51/21 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with molecular oxygen

5.

TREATMENT PLANNING SYSTEM, METHOD, AND PROGRAM

      
Application Number 18375597
Status Pending
Filing Date 2023-10-02
First Publication Date 2024-08-29
Owner
  • Hitachi, Ltd. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Takayanagi, Taisuke
  • Yamada, Takahiro
  • Hirayama, Shusuke
  • Miyazaki, Koichi
  • Kobashi, Keiji
  • Aoyama, Hidefumi
  • Hashimoto, Takayuki
  • Katoh, Norio
  • Taguchi, Hiroshi
  • Yasuda, Koichi
  • Onodera, Yasuhito

Abstract

A treatment planning system is configured to create a treatment planning for radiotherapy and includes a processing device and a memory. The memory stores a plurality of calculation models, and the processing device uses at least two of the plurality of calculation models to calculate calculation values of biological effect indices representing an effect of radiotherapy with respect to a condition for radiotherapy, and searches for the condition so that at least two of the calculation values to be calculated approach a predetermined target value.

IPC Classes  ?

  • A61N 5/10 - X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

6.

METHOD FOR DETECTING AMYLOID-ß BOUND TO BRAIN-NEURONALCELL-DERIVED EXOSOME IN BLOOD, KIT FOR DETECTION OF AMYLOID-ß BOUND TO BRAIN-NEURONAL-CELL-DERIVED EXOSOME IN BLOOD, AND METHOD FOR EVALUATING ACCUMULATION LEVEL OF AMYLOID-ß IN BRAIN

      
Application Number 18651906
Status Pending
Filing Date 2024-05-01
First Publication Date 2024-08-22
Owner
  • TOPPAN Holdings Inc. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Makino, Yoichi
  • Hirase, Takumi
  • Yuyama, Kohei

Abstract

There are provided a method for detecting amyloid-β bound to a brain-neuronal-cell-derived exosome in blood, the method including: a step of binding amyloid-β bound to the brain-neuronal-cell-derived exosome in blood to an amyloid-β-specific binding substance that specifically binds to amyloid-β, labeled with a nucleic acid fragment; and a step of detecting the amyloid-β-specific binding substance, and a method for evaluating an accumulation level of amyloid-β in a brain, the method including: a step of detecting amyloid-β bound to the brain-neuronal-cell-derived exosome in blood; and a step of evaluating an accumulation level of amyloid-β in a brain based on the detected amount of the amyloid-β.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

7.

POLYOXYETHYLENE DERIVATIVES AND CONJUGATES THEREOF

      
Application Number 18435636
Status Pending
Filing Date 2024-02-07
First Publication Date 2024-08-22
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • OSAKA UNIVERSITY (Japan)
  • NOF CORPORATION (Japan)
Inventor
  • Onoda, Akira
  • Hayashi, Takashi
  • Hamura, Ken
  • Suzuki, Akira
  • Kishida, Satoshi

Abstract

Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention: Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention: Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention: wherein the symbols in the formula are as defined in the specification, can form conjugates with polypeptide that can be degraded over a long time under physiological conditions to release the polypeptide.

IPC Classes  ?

  • A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • C12N 9/22 - Ribonucleases

8.

IGNITION DEVICE, METHOD FOR PRODUCING THE SAME, IGNITION METHOD AND ROCKET COMBUSTION SYSTEM

      
Application Number 18621655
Status Pending
Filing Date 2024-03-29
First Publication Date 2024-08-08
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kamps, Landon Thomas
  • Nagata, Harunori
  • Hirai, Shota
  • Leung, Yownin Albert
  • Nobuhara, Yuki

Abstract

The present disclosure is directed to an ignition device including a housing, a bulk fuel, and at least two lead wires as electrodes. The bulk fuel is made of a plastic material, such as polylactic acid (PLA) or epoxy resin. The bulk fuel contains an internally dispersed powdery conductive material, thereby obtaining a conductive solid fuel. One end of the lead wire is partially embedded in the bulk fuel. The other end of the lead wire is connected to a power source. A portion of the bulk fuel is gasified by energizing the lead wire, and the gasified fuel is combusted by reaction with an oxidant.

IPC Classes  ?

  • F02K 9/95 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof characterised by starting or ignition means or arrangements
  • F02K 9/08 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof using solid propellants

9.

LIPID NANOPARTICLES

      
Application Number 18561555
Status Pending
Filing Date 2022-05-19
First Publication Date 2024-07-18
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Sato, Yusuke
  • Sasaki, Kosuke
  • Harashima, Hideyoshi

Abstract

The present invention provides lipid nanoparticles that contain a pH-sensitive cationic lipid and a polyalkylene glycol-modified lipid. The pH-sensitive cationic lipid fraction of the total lipids that constitute the lipid nanoparticles is 10-25 mol %, the polyalkylene glycol-modified lipid fraction of the total lipids that constitute the lipid nanoparticles is 0.5-1.75 mol %, and the number average particle size of the lipid nanoparticles is at least 150 nm.

IPC Classes  ?

10.

Dispersion Solution for X-Ray Target, Prefilled Syringe Filled with Same, and Powder for X-Ray Target

      
Application Number 18278863
Status Pending
Filing Date 2022-02-25
First Publication Date 2024-07-11
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Yonezawa, Tetsu
  • Shirato, Hiroki
  • Miyamoto, Naoki

Abstract

A dispersion for an X-ray target in which gold nanoparticles and sodium alginate or a calcium phosphate-based bone reinforcing material are dispersed, in which the gold nanoparticles are in contact with the sodium alginate or the calcium phosphate-based bone reinforcing material.

IPC Classes  ?

11.

ULTRASONIC PHYSICAL PROPERTIES MEASUREMENT DEVICE

      
Application Number 18547795
Status Pending
Filing Date 2022-02-24
First Publication Date 2024-07-11
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Tasaka, Yuji
  • Yoshida, Taiki
  • Ohie, Kohei

Abstract

[Problem] To provide an ultrasonic physical properties measurement device that suppresses the generation of a secondary flow inside a cylinder, is more portable, and can suppress changes in physical properties. [Problem] To provide an ultrasonic physical properties measurement device that suppresses the generation of a secondary flow inside a cylinder, is more portable, and can suppress changes in physical properties. [Solution] An ultrasonic physical properties measurement device 1 that: uses ultrasonic waves to measure the flow velocity profile of fluids that flow inside a cylinder 2, by rotating the cylinder 2 backwards and forwards in a fixed cycle; and calculates the physical properties of fluid from the flow velocity profile. The cylinder 2: has an upper end surface 21 and lower end surface 22 that are penetrated such that fluid can flow therethrough; and comprises a rotation mechanism 3 that supports all or part of the cylinder 2 in a state of immersion in the fluid and rotates the cylinder 2 backwards and forwards.

IPC Classes  ?

  • G01F 1/66 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters

12.

CELL MASS-FORMING MEMBER, CULTURE VESSEL, METHOD FOR PRODUCING CULTURED CELLS, AND CULTURED CELLS WITH CELL MASS-FORMING MEMBER

      
Application Number 18546584
Status Pending
Filing Date 2022-03-29
First Publication Date 2024-07-11
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • Oji Holdings Corporation (Japan)
Inventor
  • Miyatake, Yukiko
  • Shigetomi, Kaori
  • Tokuno, Hisako
  • Dai, Kotaro
  • Shinotsuka, Kei

Abstract

A cell mass-forming member that is capable of easily forming a cell mass and superior in industrial mass productivity; a culture container equipped with the cell mass-forming member; a method for producing cultured cells using the cell mass-forming member; and cultured cells with a cell mass-forming member that are equipped with the cell mass-forming member. The cell mass-forming member has a base material, an adhesion inhibition area and a cell adhesion area are formed on the surface of the base material; a micro-concavo-convex structure area including a plurality of convex portions is formed in the cell adhesion area; and a hydrophilic coating layer is formed on both the adhesion inhibition area and the cell adhesion area. The culture container and the cultured cells with a cell mass-forming member are equipped with the cell mass-forming member. The method for producing cultured cells includes using the cell mass-forming member.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
  • C12N 5/09 - Tumour cells

13.

GLOBODERA PALLIDA CONTROL AGENT

      
Application Number 18275929
Status Pending
Filing Date 2022-01-27
First Publication Date 2024-06-13
Owner
  • NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • Nippon Soda Co., Ltd. (Japan)
Inventor
  • Kushida, Atsuhiko
  • Sakata, Itaru
  • Tanino, Keiji
  • Kato, Kousuke
  • Itabashi, Takuya
  • Kanazawa, Jun
  • Ikeda, Yuto
  • Kitayama, Takashi
  • Koizumi, Satoshi
  • Osawa, Yoko
  • Inoue, Tsutomu

Abstract

An object of the present invention is to provide an industrially easily available hatching factor on Globodera pallida larvae, a control agent and a control method using the same. The Globodera pallida control agent of the present invention contains, as an active ingredient, at least one selected from a compound of formula (I) below, a stereoisomer thereof, and a salt thereof [wherein Ar represents a substituted or unsubstituted phenyl group or the like; R1 each independently represents a group such as a substituted or unsubstituted C1 to 6 alkyl group and a substituted or unsubstituted C2 to 6 alkenyl group; R2 represents a hydrogen atom or a substituted or unsubstituted C1 to 6 alkyl group; the partial structure —Y—X— represents a group represented by *—N(Rb)—C(═X1)—**; X1 each independently represents an oxygen atom or a sulfur atom; Rb represents hydrogen atom or the like; where * indicates a binding position to the carbon atom having two R1, and ** indicates a binding position to Z; and Z represents a substituted or unsubstituted methylene group, or a substituted or unsubstituted dimethylene group.] An object of the present invention is to provide an industrially easily available hatching factor on Globodera pallida larvae, a control agent and a control method using the same. The Globodera pallida control agent of the present invention contains, as an active ingredient, at least one selected from a compound of formula (I) below, a stereoisomer thereof, and a salt thereof [wherein Ar represents a substituted or unsubstituted phenyl group or the like; R1 each independently represents a group such as a substituted or unsubstituted C1 to 6 alkyl group and a substituted or unsubstituted C2 to 6 alkenyl group; R2 represents a hydrogen atom or a substituted or unsubstituted C1 to 6 alkyl group; the partial structure —Y—X— represents a group represented by *—N(Rb)—C(═X1)—**; X1 each independently represents an oxygen atom or a sulfur atom; Rb represents hydrogen atom or the like; where * indicates a binding position to the carbon atom having two R1, and ** indicates a binding position to Z; and Z represents a substituted or unsubstituted methylene group, or a substituted or unsubstituted dimethylene group.]

IPC Classes  ?

  • A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
  • A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom
  • A01N 43/10 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with sulfur as the ring hetero atom
  • A01N 43/36 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
  • A01N 43/38 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
  • A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
  • A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
  • A01P 5/00 - Nematocides

14.

CATALYST STRUCTURE FOR SYNTHESIS GAS PRODUCTION, SYNTHESIS GAS PRODUCTION DEVICE, AND METHOD FOR PRODUCING CATALYST STRUCTURE FOR SYNTHESIS GAS PRODUCTION

      
Application Number 18553120
Status Pending
Filing Date 2022-03-30
First Publication Date 2024-06-13
Owner
  • FURUKAWA ELECTRIC CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Banba, Yuichiro
  • Fukushima, Masayuki
  • Kawamata, Yuki
  • Iwano, Yuki
  • Mori, Tomohiko
  • Fujikawa, Takashi
  • Masuda, Takao
  • Nakasaka, Yuta
  • Yoshikawa, Takuya

Abstract

A catalyst structure for synthesis gas production is used to produce a synthesis gas that includes carbon monoxide and hydrogen. The structure includes a carrier with a porous structure that comprises a zeolite-type compound; first catalyst particles that contain at least one iron-group element selected from the group consisting of nickel, iron, and cobalt; and a second catalyst that contains at least one transition metal element with redox capacity. The carrier includes, inside thereof, mutually communicating passages; the first catalyst particles are present at least in the passages of the carrier; and the second catalyst is present at least in the interior or on an outer surface of the carrier.

IPC Classes  ?

  • B01J 29/035 - Crystalline silica polymorphs, e.g. silicalites
  • B01J 35/45 - Nanoparticles
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/10 - Heat treatment in the presence of water, e.g. steam
  • C01B 3/40 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts characterised by the catalyst

15.

SEPARATION SYSTEM AND SEPARATION METHOD

      
Application Number 18515315
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-05-30
Owner
  • HONDA MOTOR CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Furusawa, Koichiro
  • Takahashi, Kazuyuki
  • Murata, Naoki
  • Matsushima, Hisayoshi
  • Nago, Toranosuke

Abstract

An object of the present invention is to provide a separation system and a separation method that can separate deuterium from a fluid containing light hydrogen and deuterium with high separation efficiency while suppressing equipment deterioration. The present invention provides a separation system including a plurality of separation devices connected in series; each of the plurality of separation devices includes an electrolyte membrane to which an anode catalyst layer and a cathode catalyst layer are provided; a first inflow passage through which a first fluid containing light hydrogen and deuterium flows in, and a first outflow passage through which a second fluid having a lower deuterium content than that of the first fluid flows out are connected to an anode flow passage, a second inflow passage through which a third fluid flows into and a second outflow passage through which a fourth fluid containing light water and heavy water flows out are connected to a cathode flow passage; at least a separation device provided at the most upstream side among the plurality of separation devices is a first separation device into which a gas containing water vapor flows as a third fluid, and from which the third fluid and deuterium that has moved from the anode catalyst layer into the cathode catalyst layer are discharged as the fourth fluid.

IPC Classes  ?

  • B01D 59/40 - Separation by electrochemical methods by electrolysis
  • B01D 59/42 - Separation by electrochemical methods by electrophoresis
  • C25B 1/01 - Products
  • C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
  • C25B 9/70 - Assemblies comprising two or more cells

16.

METHOD FOR PRODUCING LAYERED COMPOSITE METAL OXIDE CRYSTAL MATERIAL

      
Application Number 18282351
Status Pending
Filing Date 2022-03-17
First Publication Date 2024-05-16
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Matsui, Masaki
  • Maeda, Rannosuke

Abstract

The objective of the present invention is to provide a method for producing a layered composite metal oxide crystal material, which can be utilized as a positive electrode material for a lithium ion secondary battery or the like, in a milder condition, and methods for producing a positive electrode and a lithium ion secondary battery using the above method. The method for producing a layered composite metal oxide crystal material according to the present invention, wherein the layered composite metal oxide crystal material comprises a composite metal oxide represented by the formula: LixMOy wherein M is 1 or 2 or more of transition metals, and a part of the M may be substituted with Al and/or Mg, x is the number of 1 or more and 2 or less, y is the number of 2 or more and 3 or less, a value of x+n is 2×y, wherein n is an average valence of the transition metal M, is characterized in comprising the step of calcining a mixture comprising a monovalent anion salt of lithium, a monovalent anion salt of sodium and/or potassium, and a monovalent anion salt of the transition metal at 150° C. or higher and 400° C. or lower in the presence of a water molecule and oxygen.

IPC Classes  ?

  • H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
  • C01G 51/00 - Compounds of cobalt
  • C01G 53/00 - Compounds of nickel
  • H01M 4/02 - Electrodes composed of, or comprising, active material
  • H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
  • H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
  • H01M 10/0587 - Construction or manufacture of accumulators having only wound construction elements, i.e. wound positive electrodes, wound negative electrodes and wound separators

17.

COMPOUND, MANUFACTURING METHOD THEREFOR, ANTIMICROBIAL AGENT, AND MEDICINAL DRUG

      
Application Number 18396272
Status Pending
Filing Date 2023-12-26
First Publication Date 2024-05-16
Owner
  • Murata Manufacturing Co., Ltd. (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Takata, Masachika
  • Sunahara, Hirofumi
  • Wakimoto, Toshiyuki
  • Matsuda, Kenichi

Abstract

A compound represented by Formula (1), Formula (2), or Formula (3), or a salt thereof, or a solvate thereof: A compound represented by Formula (1), Formula (2), or Formula (3), or a salt thereof, or a solvate thereof: wherein R1, R2, and R3 are the same or different and each represent a hydrazine group, an N-hydroxy-acetylamino group, or an N-hydroxy-formylamino group.

IPC Classes  ?

18.

SLIDE NUMBER ESTIMATION APPARATUS, CONTROL METHOD, AND NON-TRANSITORY COMPUTER READABLE MEDIUM

      
Application Number 18283698
Status Pending
Filing Date 2022-02-01
First Publication Date 2024-05-16
Owner
  • NCE CORPORATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Amakawa, Ayaka
  • Sano, Maki
  • Hatanaka, Hokkaido
  • Hatanaka, Yutaka

Abstract

A slide number estimation apparatus (2000) acquires a slide image (30). The slide image (30) an image of a specimen slide (20) obtained from a tissue piece (10) of a subject. The slide number estimation apparatus (2000) estimates the number of tumor cells included in a region of interest (22) of the specimen slide (20) corresponding to the obtained slide image (30) using the slide image (30). The slide number estimation apparatus (2000) estimates the number of the specimen slides (20) to be obtained from the tissue piece (10) for conducting a predetermined test based on the estimated number of tumor cells.

IPC Classes  ?

19.

METHOD FOR DETECTING AND QUANTIFYING NUCLEIC ACID FROM ENVIRONMENTAL SAMPLES

      
Application Number 18278876
Status Pending
Filing Date 2022-02-25
First Publication Date 2024-05-09
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • Shionogi & Co., Ltd. (Japan)
Inventor
  • Kitajima, Masaaki
  • Iwamoto, Ryo
  • Masago, Yusaku
  • Hayase, Shin
  • Katayama Adachi, Yuka

Abstract

The present invention provides a method for quantitatively detecting virus-derived RNA and/or DNA in an environmental sample or a fecal sample with high sensitivity, and a kit for quantitatively detecting virus-derived RNA and/or DNA in an environmental sample or a fecal sample with high sensitivity.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

20.

COPPER CHELATOR, ANTICANCER AGENT AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR WILSON'S DISEASE

      
Application Number 18396305
Status Pending
Filing Date 2023-12-26
First Publication Date 2024-05-02
Owner
  • Murata Manufacturing Co., Ltd. (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Takata, Masachika
  • Sunahara, Hirofumi
  • Wakimoto, Toshiyuki
  • Matsuda, Kenichi

Abstract

A copper chelating agent that contains at least one compound selected from the group consisting of a compound represented by Formula (1), a compound represented by Formula (2), a compound represented by Formula (3), a compound represented by Formula (4), a salt thereof, and a solvate thereof: A copper chelating agent that contains at least one compound selected from the group consisting of a compound represented by Formula (1), a compound represented by Formula (2), a compound represented by Formula (3), a compound represented by Formula (4), a salt thereof, and a solvate thereof:

IPC Classes  ?

21.

ANTI-VIRAL AGENT

      
Application Number 18262326
Status Pending
Filing Date 2022-01-20
First Publication Date 2024-04-25
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Maenaka, Katsumi
  • Matsuda, Akira
  • Sawa, Hirofumi
  • Orba, Yasuko
  • Sasaki, Michihito
  • Uemura, Kentaro

Abstract

[Problem] The present invention has as an object to provide an antiviral agent effective as a remedy for COVID-1 9 and other viral infections. [Problem] The present invention has as an object to provide an antiviral agent effective as a remedy for COVID-1 9 and other viral infections. [Resolution Means] Provided is an antiviral agent and the like, made of: the compound represented by general formula (1) or (2) below [R1 being —(CH2)n1—Z1—R11 2 r —CH—(—Z1—R11,)(n1 being 0 or 1; Z1 being a single bond, —O—, —NH—, —S—, —SO—, —SO2—,SO—CO—, —CO—O—, or —CH═N—O—; R11 being a hydrogen atom, an alkyl group having 1 to 6 carbons, —NR12 R13, —N3,—NO2,—CN, —CH2—CO—O—R14, or a five- or six-membered heterocyclic group including a nitrogen atom; R12 and R13 each independently being a hydrogen atom or an alkyl group having 1 to 6 carbons; and R14 being a hydrogen atom or an alkyl group having 1 to 6 carbons], a derivative thereof, a salt of these compounds, or a solvate thereof. [Problem] The present invention has as an object to provide an antiviral agent effective as a remedy for COVID-1 9 and other viral infections. [Resolution Means] Provided is an antiviral agent and the like, made of: the compound represented by general formula (1) or (2) below [R1 being —(CH2)n1—Z1—R11 2 r —CH—(—Z1—R11,)(n1 being 0 or 1; Z1 being a single bond, —O—, —NH—, —S—, —SO—, —SO2—,SO—CO—, —CO—O—, or —CH═N—O—; R11 being a hydrogen atom, an alkyl group having 1 to 6 carbons, —NR12 R13, —N3,—NO2,—CN, —CH2—CO—O—R14, or a five- or six-membered heterocyclic group including a nitrogen atom; R12 and R13 each independently being a hydrogen atom or an alkyl group having 1 to 6 carbons; and R14 being a hydrogen atom or an alkyl group having 1 to 6 carbons], a derivative thereof, a salt of these compounds, or a solvate thereof.

IPC Classes  ?

  • A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
  • A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
  • A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
  • A61P 31/14 - Antivirals for RNA viruses

22.

COMPOSITION FOR REGENERATION OF INTERVERTEBRAL DISC

      
Application Number 18273654
Status Pending
Filing Date 2022-01-28
First Publication Date 2024-03-28
Owner
  • National University Corporation Hokkaido University (Japan)
  • PuREC Co., Ltd. (Japan)
  • Mochida Pharmaceutical Co., Ltd. (Japan)
Inventor
  • Sudo, Hideki
  • Ukeba, Daisuke
  • Yamada, Katsuhisa
  • Ura, Katsuro
  • Suzuki, Hisataka
  • Iyoku, Yumi
  • Suyama, Takashi

Abstract

Provided is a composition for promotion of the regeneration of the nucleus pulposus of an intervertebral disc, said composition comprising a low endotoxin monovalent metal salt of alginic acid and mesenchymal stem cells. In particular, the composition of the present invention promotes the regeneration of the nucleus pulposus of an intervertebral disc via activation of nucleus pulposus cells by human bone marrow-derived high-purity mesenchymal stem cells and/or differentiation of human bone marrow-derived high-purity mesenchymal stem cells into nucleus pulposus cells.

IPC Classes  ?

  • A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
  • A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

23.

RECEPTION DEVICE, QUANTUM KEY DISTRIBUTION SYSTEM, AND METHOD FOR DETECTING QUANTUM SIGNAL

      
Application Number 18274871
Status Pending
Filing Date 2022-01-24
First Publication Date 2024-03-14
Owner
  • NEC CORPORATION (Japan)
  • NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • THE UNIVERSITY OF TOKYO (Japan)
Inventor
  • Yoshino, Ken-Ichiro
  • Fujiwara, Mikio
  • Tomita, Akihisa
  • Koashi, Masato
  • Takeoka, Masahiro
  • Sasaki, Masahide

Abstract

An object is to prevent eavesdropping in quantum key distribution. A decoding unit decodes a quantum signal incident thereinto. A plurality of detect photons of the decoded quantum signal output from the decoding unit. A signal processing unit detects bits of the decoded quantum signal based on photon detection results of the plurality of detectors. A control unit perform switching processing by switching destinations to which two decoded quantum signals corresponding to one encoding basis are output between the plurality of detectors, and switching the bits detected by the signal processing unit based on the respective photon detection results of the plurality of detectors.

IPC Classes  ?

  • H04L 9/08 - Key distribution
  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

24.

HEAT-RESISTANT ALLOY, HEAT-RESISTANT ALLOY POWDER, HEAT-RESISTANT ALLOY STRUCTURAL COMPONENT, AND MANUFACTURING METHOD OF THE SAME

      
Application Number 18384449
Status Pending
Filing Date 2023-10-27
First Publication Date 2024-03-07
Owner
  • TOKYO METROPOLITAN PUBLIC UNIVERSITY CORPORATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kakehi, Koji
  • Hayashi, Shigenari
  • Kuo, Yen-Ling

Abstract

A heat-resistant alloy contains Y, a content of Ni is a content of Ni is 58.0 mass % or greater, a content of Cr is 20.0 mass % or greater and 23.0 mass % or less, a content of Mo is 8.0 mass % or greater and 10.0 mass % or less, a content of Nb is 3.15 mass % or greater and 4.15 mass % or less, a content of O is 0.002 mass % or greater and 0.1 mass % or less, and a ratio of a content of Y in terms of mass to a content of O in terms of mass is 0.5 or greater and 100 or less.

IPC Classes  ?

  • C22C 1/04 - Making non-ferrous alloys by powder metallurgy
  • B22F 1/00 - Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
  • B33Y 70/00 - Materials specially adapted for additive manufacturing
  • C22C 19/05 - Alloys based on nickel or cobalt based on nickel with chromium
  • C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon

25.

LIPID NANOPARTICLE

      
Application Number 18277409
Status Pending
Filing Date 2022-02-17
First Publication Date 2024-02-15
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Nakamura, Takashi
  • Harashima, Hideyoshi
  • Sato, Yusuke
  • Yamada, Koharu
  • Nakade, Taisei

Abstract

The present invention provides a lipid nanoparticle and the like containing a pH-sensitive cationic lipid represented by formula (1) (in formula (1), R1 and R2 are each independently a straight-chain C10-14 alkyl group, a straight-chain C10-20 alkenyl group having one or two unsaturated bonds, or —CH(R5)(R6)(where R5 and R6 are each independently a straight-chain C5-10 alkyl group); p represents an integer of 3-8; and R3 and R4 are each independently a methyl group or an ethyl group]. The present invention provides a lipid nanoparticle and the like containing a pH-sensitive cationic lipid represented by formula (1) (in formula (1), R1 and R2 are each independently a straight-chain C10-14 alkyl group, a straight-chain C10-20 alkenyl group having one or two unsaturated bonds, or —CH(R5)(R6)(where R5 and R6 are each independently a straight-chain C5-10 alkyl group); p represents an integer of 3-8; and R3 and R4 are each independently a methyl group or an ethyl group].

IPC Classes  ?

  • A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • A61K 9/127 - Liposomes
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • A61P 35/00 - Antineoplastic agents

26.

ANTI-TUMOR PEPTIDE AND USE THEREOF

      
Application Number 17761255
Status Pending
Filing Date 2021-08-18
First Publication Date 2024-02-08
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Matsuda, Tadashi
  • Oritani, Kenji
  • Kitai, Yuichi

Abstract

The present invention provides a peptide that consists of an amino acid sequence with 20 or fewer residues containing at least one amino acid sequence selected from the group consisting of the amino acid sequence represented in SEQ ID NO: 1, the amino acid sequence represented in SEQ ID NO: 2 and the amino acid sequence represented in SEQ ID NO: 38, the peptide having an activity to inhibit proliferation of a tumor cell or having an activity to inhibit binding between an epidermal growth factor receptor and a signal-transducing adaptor family member-2 (STAP-2); a peptide with a cell-penetrating peptide added to a terminus of the above peptide with or without a linker sequence interposed between the cell-penetrating peptide and the terminus; and pharmaceutical compositions containing any of these peptides.

IPC Classes  ?

  • C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
  • A61P 35/00 - Antineoplastic agents

27.

Printed Board Coil, High Frequency Transformer, and Electromagnetic Induction Heater

      
Application Number 18204027
Status Pending
Filing Date 2023-05-31
First Publication Date 2024-02-08
Owner
  • Hitachi, Ltd. (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Kawaguchi, Yuki
  • Shoji, Hiroyuki
  • Orikawa, Koji
  • Ogasawara, Satoshi
  • Murakami, Naoki

Abstract

A printed board coil forms a coil with a plurality of turns, each formed by stacking a first layer having a first winding pattern and a second layer having a second winding pattern while having an insulation layer intervening therebetween. The first layers and the second layers are used for forming each of the coils. The coils are stacked having each of the insulation layers intervening between the coils by arranging the first layer and the second layer alternately in the stacking direction of the respective layers. The coils are connected in parallel to one another.

IPC Classes  ?

  • H01F 17/00 - Fixed inductances of the signal type
  • H01F 27/28 - Coils; Windings; Conductive connections
  • H05K 1/16 - Printed circuits incorporating printed electric components, e.g. printed resistor, capacitor, inductor

28.

LIPID NANOPARTICLE

      
Application Number 18247612
Status Pending
Filing Date 2021-10-01
First Publication Date 2024-01-25
Owner
  • National University Corporation Hokkaido University (Japan)
  • Nitto Denko Corporation (Japan)
Inventor
  • Sato, Yusuke
  • Harashima, Hideyoshi
  • Hashiba, Kazuki
  • Taguchi, Masamitsu
  • Sakamoto, Sachiko
  • Shishido, Takuya
  • Otsu, Ayaka
  • Maeda, Yoshiki

Abstract

The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4). The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4). (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I) The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4). (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I) (R11)(R12)—CH—(CO—O)c—(CH2)v-  (A) The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4). (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I) (R11)(R12)—CH—(CO—O)c—(CH2)v-  (A) —(CH2)d—N(R3)(R4)  (B)

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

29.

METHOD OF PRODUCING CANCER STEM CELLS

      
Application Number 18480956
Status Pending
Filing Date 2023-10-04
First Publication Date 2024-01-25
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Tanaka, Shinya
  • Yasuda, Kazunori
  • Gong, Jian Ping
  • Tsuda, Masumi
  • Kurokawa, Takayuki

Abstract

The present invention relates to a method of producing cancer stem cells that comprises culturing a living cell population containing cancer cells in the presence of a gel substance to obtain a living cell population containing cancer stem cells, wherein the gel substance is a material that induces expression of osteopontin in at least a portion of cells contained in the living cell population. Moreover, the present invention relates to an agent for inducing conversion of cancer cells to cancer stem cells that comprises a gel substance that induces expression of osteopontin in at least a portion of the cells contained in a living cell population. The gel substance is a synthetic polymer gel composed of, for example, double network gel, PNaSS gel, PCDME gel, PA gel, PAMPS gel, PDMA gel or PAAc gel. The present invention provides means and a method that enable the preparation of cancer stem cells in a relatively short period of time and at a relatively low culturing cost without requiring expensive equipment.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
  • C12N 5/095 - Stem cells; Progenitor cells
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

30.

DIELECTRIC COMPOSITION, CAPACITIVE ELEMENT, VISIBLE-LIGHT PHOTOCATALYTIC MATERIAL, AND VISIBLE-LIGHT PHOTOELECTRIC CONVERSION ELEMENT

      
Application Number 18348417
Status Pending
Filing Date 2023-07-07
First Publication Date 2024-01-11
Owner
  • TDK CORPORATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Yamazaki, Kumiko
  • Kano, Shuto
  • Masubuchi, Yuji
  • Kikkawa, Shinichi

Abstract

A dielectric composition comprises a crystal of an oxynitride. A peak attributed to absence of a center of symmetry of the crystal of the oxynitride is detected by Raman spectroscopy of the dielectric composition within a Raman shift range of 500 cm−1 or less.

IPC Classes  ?

  • C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
  • B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
  • C23C 16/515 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating using electric discharges using pulsed discharges

31.

LIGHT IRRADIATION DEVICE

      
Application Number 18032678
Status Pending
Filing Date 2020-12-01
First Publication Date 2023-12-07
Owner
  • JAPAN LIFELINE CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kodama, Yuki
  • Kuwatani, Masaki
  • Hirata, Hajime
  • Ogawa, Mikako
  • Nakajima, Kohei

Abstract

A light irradiation device includes a tube including a tube main body and a light emitting portion, a plurality of wiring boards disposed inside the light emitting portion and including a plurality of light emitting elements disposed at an equal interval mounted, an anode lead wire for connecting an anode terminal of each of the wiring boards to a power source, and a cathode lead wire for connecting a cathode terminal of each of the wiring boards to the power source. In the light emitting portion, a central lumen and surrounding lumens that are arrayed at a 90° interval around the central lumen are formed. The wiring boards are disposed in the respective surrounding lumens with the light emitting elements arrayed along a longitudinal direction of the light emitting portion.

IPC Classes  ?

32.

METHOD FOR OBTAINING INFORMATION ON VON WILLEBRAND FACTOR, MEASUREMENT SAMPLE PREPARATION METHOD, AND REAGENT KIT

      
Application Number 18314944
Status Pending
Filing Date 2023-05-10
First Publication Date 2023-11-16
Owner
  • National University Corporation Hokkaido University (Japan)
  • SYSMEX CORPORATION (Japan)
Inventor
  • Kinjo, Masataka
  • Ganguly, Akshay
  • Ramaswamy, Lausonia

Abstract

Disclosed is a method for obtaining information on von Willebrand factor (VWF), comprising the following steps: denaturing, with urea, VWF contained in a biological sample; fluorescently labeling the denatured VWF using a capturing agent that comprises a fluorescent substance and binds to the denatured VWF; and obtaining information on the size of the fluorescently-labeled VWF by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy.

IPC Classes  ?

  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

33.

Method of Culturing Alga and Alga Culture System

      
Application Number 18025769
Status Pending
Filing Date 2021-09-10
First Publication Date 2023-11-02
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Sato, Masahiro
  • Nakashima, Takumi
  • Ishii, Kazuei
  • Ochiai, Satoru

Abstract

The present invention provides a method of culturing an alga that enables practical realization of low-cost and space-saving production of biofuels and bioenergy by culturing the alga using a reaction tank equipped with a digestive solution tank comprising digestive solution containing high concentration of nutrient salts, a membrane with a pore size of 0.45 µm or less and a culture tank comprising culture solution and the alga, which comprises consuming the nutrient salts by the alga in the culture tank to maintain the difference in concentration the nutrient salts between the digestive solution tank and the culture tank and supplying the nutrient salts contained in the digestive solution through the membrane into the culture solution by the diffusion depending on the concentration difference as well as an alga culture system therefor.

IPC Classes  ?

  • C12N 1/12 - Unicellular algae; Culture media therefor
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 61/14 - Ultrafiltration; Microfiltration
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • B01D 61/24 - Dialysis

34.

METHOD FOR MAKING FUNCTIONAL STRUCTURAL BODY

      
Application Number 18303034
Status Pending
Filing Date 2023-04-19
First Publication Date 2023-10-19
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • FURUKAWA ELECTRIC CO., LTD. (Japan)
Inventor
  • Masuda, Takao
  • Nakasaka, Yuta
  • Yoshikawa, Takuya
  • Kato, Sadahiro
  • Fukushima, Masayuki
  • Inamori, Kojiro
  • Takahashi, Hiroko
  • Banba, Yuichiro
  • Sekine, Kaori

Abstract

A method for making a functional structural body includes a skeletal body of a porous structure composed of a zeolite-type compound, and at least one type of metallic nanoparticles present in the skeletal body, the skeletal body having channels connecting with each other, the metallic nanoparticles being present at least in the channels of the skeletal body.

IPC Classes  ?

  • B01J 29/14 - Iron group metals or copper
  • B01J 29/46 - Iron group metals or copper
  • B01J 29/68 - Iron group metals or copper
  • B01J 29/76 - Iron group metals or copper
  • B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
  • B01J 37/00 - Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/10 - Heat treatment in the presence of water, e.g. steam
  • B01J 37/18 - Reducing with gases containing free hydrogen
  • B01J 29/064 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof containing iron group metals, noble metals or copper
  • B01J 29/035 - Crystalline silica polymorphs, e.g. silicalites
  • B01J 29/068 - Noble metals
  • B01J 29/076 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/22 - Noble metals
  • B01J 29/16 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/18 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type
  • B01J 29/072 - Iron group metals or copper
  • B01J 29/08 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y
  • B01J 29/20 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type containing iron group metals, noble metals or copper
  • B01J 29/10 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y containing iron group metals, noble metals or copper
  • B01J 29/12 - Noble metals
  • B01J 29/62 - Noble metals
  • B01J 29/48 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11 containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/60 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the type L
  • B01J 29/44 - Noble metals
  • B01J 29/24 - Iron group metals or copper
  • B01J 29/61 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the type L containing iron group metals, noble metals or copper
  • B01J 29/26 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/42 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11 containing iron group metals, noble metals or copper
  • B01J 29/40 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
  • B01J 29/69 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38 containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/63 - Iron group metals or copper
  • B01J 29/70 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups
  • B01J 29/65 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38
  • B01J 29/67 - Noble metals
  • B01J 29/66 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38 containing iron group metals, noble metals or copper
  • B01J 29/64 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the type L containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/74 - Noble metals
  • B01J 29/78 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/72 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups containing iron group metals, noble metals or copper
  • B01J 35/02 - Solids
  • F01N 3/28 - Construction of catalytic reactors
  • C01B 39/02 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
  • B01D 53/94 - Chemical or biological purification of waste gases of engine exhaust gases by catalytic processes

35.

METHOD FOR DIAGNOSING NONALCOHOLIC STEATOHEPATITIS

      
Application Number 18024955
Status Pending
Filing Date 2021-06-15
First Publication Date 2023-10-19
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Sakurai, Toshihiro
  • Hui, Shu-Ping
  • Chiba, Hitoshi

Abstract

A problem of the present invention is to provide a diagnostic biomarker of nonalcoholic steatohepatitis (NASH) useful for differentiation of simple steatosis (SS) from NASH and use thereof. Specifically, the present invention relates to a diagnostic biomarker of nonalcoholic steatohepatitis used to differentiate nonalcoholic steatohepatitis from simple steatosis comprising the oxidized apolipoprotein A-I (ApoA-I) modified by dioxidation of the 72nd tryptophan in the ApoA-I consisting of the amino acid sequence as shown in SEQ ID NO: 1.

IPC Classes  ?

  • G01N 33/92 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol

36.

COMMON MODE FILTER CIRCUIT AND DRIVE DEVICE

      
Application Number 18326081
Status Pending
Filing Date 2023-05-31
First Publication Date 2023-09-28
Owner
  • IHI Corporation (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Yamaguchi, Koji
  • Ogasawara, Satoshi
  • Ohara, Shunsuke

Abstract

A common mode filter circuit comprises a common mode transformer unit, an inverter, and a capacitor unit. Each of the first common mode transformer, the second common mode transformer, and the third common mode transformer comprises a first secondary wound wire, a second secondary wound wire, a third secondary wound wire, and a primary wound wire. A ratio of a number of turns of the primary wound wire to a number of turns of the first secondary wound wire, a ratio of a number of turns of the primary wound wire to a number of turns of the second secondary wound wire, and a ratio of a number of turns of the primary wound wire to a number of turns of the third secondary wound wire are each 3:1 in each of the first common mode transformer, the second common mode transformer, and the third common mode transformer.

IPC Classes  ?

  • H03H 7/01 - Frequency selective two-port networks
  • H01F 27/28 - Coils; Windings; Conductive connections
  • H01F 27/29 - Terminals; Tapping arrangements

37.

CELL CULTURE SUBSTRATE, CANCER CELL AGGREGATE AND METHOD FOR MANUFACTURING SAME USING SAID SUBSTRATE, AND DRUG SCREENING METHOD USING SAID CANCER CELL AGGREGATE

      
Application Number 18147939
Status Pending
Filing Date 2022-12-29
First Publication Date 2023-09-14
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Miyatake, Yukiko
  • Shigetomi, Kaori
  • Okajima, Takaharu
  • Kasahara, Masanori

Abstract

A method for producing a cancer cell aggregate having certain properties, screening a drug for preventing and/or treating cancer, and determining anoikis resistance in epithelial cancer cells. The method includes culturing cells using a cell culture substrate having a base material and a biocompatible polymer layer. The cell culture substrate has rough sections not covered with the biocompatible polymer layer on the surface of the cell culture substrate. Each of the rough sections has a shape of a spot with a diameter of 20-100 μm, or a groove with a width of 3-30 μm with an end part of the rough section being optionally connected to another rough section. A distance between two adjacent rough sections is at least 10 μm or more, and the rough section has an uneven structure with a height ranging from 20 nm to 200 nm on the surface.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12N 5/09 - Tumour cells
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

38.

SOLUTION SEARCH SYSTEM, SOLUTION SEARCH METHOD, AND SOLUTION SEARCH PROGRAM

      
Application Number 18140426
Status Pending
Filing Date 2023-04-27
First Publication Date 2023-09-14
Owner
  • Amoeba Energy Co., Ltd. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Aono, Masashi
  • Kasai, Seiya
  • Ohkoda, Kaori
  • Fukuda, Shingo

Abstract

A solution-searching system encompasses an output adjustment unit having N signal adjustment circuits for converting provisional output-adjustment signals into final output-adjustment signals, 2N data generation units for generating binary data, 2N data conversion units which convert the binary data into information, a fluctuation setting unit for suppling bias probabilities to the signal adjustment circuits, fluctuation probabilities to the data generation units, and threshold values to the data conversion units, setting occurrence-frequencies of the binary data for making an occurrence-frequency of a specific variable, and a feedback control unit for determining whether an optimal solution has been found based on the information converted by the data conversion units and search-problem information preliminarily entered, by repeating transmission of the final output-adjustment signals to the output adjustment units, if the optimal solution has not been found.

IPC Classes  ?

  • G06F 30/3323 - Design verification, e.g. functional simulation or model checking using formal methods, e.g. equivalence checking or property checking

39.

COLLATION APPARATUS, COLLATION METHOD, AND COLLATION PROGRAM

      
Application Number 18101418
Status Pending
Filing Date 2023-01-25
First Publication Date 2023-09-07
Owner
  • Hitachi, Ltd. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Lei, Miaomei
  • Nakamura, Takahiro
  • Takemoto, Takashi
  • Mayama, Michinori

Abstract

An object of the invention is to improve reliability of an annotation. A collation apparatus includes: a grouping processing unit configured to group, based on each explanatory variable of a sample group, the sample group into a first group indicating a first classification and a second group indicating a second classification having a lower evaluation than the first classification; a collation unit configured to collate the classification of the first group and the second group that are obtained by the grouping processing unit with a classification identified by each objective variable of the sample group; and an output unit configured to output a collation result obtained by the collation unit.

IPC Classes  ?

  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

40.

METHOD FOR PRODUCING ORGANOMETALLIC NUCLEOPHILE AND REACTION METHOD USING ORGANOMETALLIC NUCLEOPHILE

      
Application Number 17996070
Status Pending
Filing Date 2022-03-18
First Publication Date 2023-08-31
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Ito, Hajime
  • Kubota, Koji

Abstract

A method for producing an organometallic nucleophile includes reacting an organohalide and a metal or metal compound with each other by a mechanochemical process in the presence of an ether compound in an amount of 0.5 to 10.0 equivalents relative to 1 equivalent of the organohalide. By utilizing the method, a method for producing an organometallic nucleophile can be performed without using a large-scale apparatus, a reaction method for reactions between an organometallic nucleophile and various organic electrophiles can be performed by an efficient and simplified means, and a simplified method for producing an organometallic nucleophile can be performed with high reactivity.

IPC Classes  ?

  • C07F 13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic System
  • C07F 3/02 - Magnesium compounds
  • C07B 49/00 - Grignard reactions

41.

SEMICONDUCTOR OPTICAL DEVICE AND METHOD OF MANUFACTURING THE SAME

      
Application Number 18106049
Status Pending
Filing Date 2023-02-06
First Publication Date 2023-08-31
Owner
  • Sumitomo Electric Industries, Ltd. (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Kono, Naoya
  • Fujiwara, Naoki
  • Saitoh, Kunimasa
  • Fujisawa, Takeshi
  • Sato, Takanori

Abstract

A semiconductor optical device includes a substrate formed of silicon and having a first optical waveguide and a semiconductor element formed of a III-V compound semiconductor and having a second optical waveguide, the semiconductor element being bonded to an upper surface of the substrate. The first optical waveguide and the second optical waveguide form a directional coupler.

IPC Classes  ?

  • H01S 5/10 - Construction or shape of the optical resonator
  • H01S 5/22 - Structure or shape of the semiconductor body to guide the optical wave having a ridge or a stripe structure
  • H01S 5/343 - Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser

42.

Information processing system and spectroscopic measuring instrument

      
Application Number 17686021
Grant Number 11768152
Status In Force
Filing Date 2022-03-03
First Publication Date 2023-08-10
Grant Date 2023-09-26
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Takahashi, Yukihiro
  • Ono, Tatsuharu
  • Naruse, Nobuyasu
  • Ishida, Yurino

Abstract

An information processing system includes a storage, an interface device, and a computing circuit. The storage stores a database, in which spectrum data concerning light from a light source and a measurement condition data at a time of measurement of the light are associated with a plant status data concerning growth of a plant and/or a harvest data concerning a harvest of the plant. The interface device receives an input of a user measurement condition which is to be applied at a time of measurement of the plant by a user and which includes data concerning angles at the time of measurement and data concerning a plant status and/or a harvest to be predicted. The computing circuit determines at least two wavelengths contained in the light from the light source to be measured under the user measurement condition by referring to the database based on the user measurement condition.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 21/03 - Cuvette constructions

43.

ACQUISITION METHOD OF VALUE RELATING TO TRIGLYCERIDE METABOLIC CAPACITY, PRESENTATION METHOD OF DISEASE INFORMATION, PRESENTATION METHOD OF DISEASE DIFFERENTIATION INFORMATION, PRESENTATION METHOD OF THERAPY EFFICACY INFORMATION, PRESENTATION METHOD OF THERAPEUTIC EFFECT INFORMATION, TEST REAGENT AND TEST KIT

      
Application Number 18014582
Status Pending
Filing Date 2021-07-07
First Publication Date 2023-08-10
Owner
  • OSAKA UNIVERSITY (Japan)
  • RIKEN (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Hirano, Ken-Ichi
  • Hara, Yasuhiro
  • Kashiwagi, Hirokazu
  • Suzuki, Akira
  • Jin, Takashi
  • Monde, Kenji
  • Murai, Yuta

Abstract

Provided are a method for acquiring a value relating to a triglyceride metabolic capacity of a subject within a shorter period of time compared to conventional nuclear medicine methods, and a test reagent and a test kit that are to be used in the acquisition method. This problem can be solved by an acquisition method of a value relating to the triglyceride metabolic capacity in leucocytes of a subject, said method comprising: a first step of mixing, in vitro, a fatty acid compound labeled with a fluorescent substance with leucocytes collected from the subject and thus bringing the fatty acid labeled with the fluorescent substance into contact with the leucocytes, wherein the fatty acid compound contains a fatty acid residue, the fatty acid residue has 8-26 carbon atoms, and a part of hydrogen atoms constituting the fatty acid residue, excluding a terminal methyl group of the fatty acid residue, may be substituted by an alkyl group having 1-3 carbon atoms; and a second step of acquiring, as the value relating to the triglyceride metabolic capacity, a measured fluorescence intensity that is derived from the fluorescent label in the leucocytes.

IPC Classes  ?

  • G01N 33/92 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol
  • G01N 33/533 - Production of labelled immunochemicals with fluorescent label
  • C07C 229/34 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings

44.

Spectroscopic measuring instrument

      
Application Number 17684660
Grant Number 11768109
Status In Force
Filing Date 2022-03-02
First Publication Date 2023-08-10
Grant Date 2023-09-26
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Takahashi, Yukihiro
  • Moteki, Youhei
  • Naruse, Nobuyasu

Abstract

The spectroscopic measuring instrument includes: a spectrometer to make measurement of a reflection spectrum of an object relative to a light source and output measurement information representing a result of the measurement; a shadow projector including obstacle(s) to allow light from the light source to cast shadow(s) on an object surface; an imaging device to output image information representing an image of an imaging area including the object surface; a storage interface removably connectable to a computer readable medium; and a processing device. The processing device is connected to the spectrometer, the imaging device and the storage interface, and performs a measurement process of storing the measurement information from the spectrometer and the image information from the imaging device in the computer readable medium connected to the storage interface.

IPC Classes  ?

  • G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01J 3/28 - Investigating the spectrum

45.

FUNCTIONAL POLYPEPTIDES AND USE THEREOF

      
Application Number 17642339
Status Pending
Filing Date 2021-04-07
First Publication Date 2023-08-03
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Sakai, Ryuichi
  • Nakano, Koji

Abstract

A polypeptide that comprises the amino acid sequence of SEQ ID NO: 1 and has a function of delivering a substance into cells, a polypeptide that comprises the amino acid sequence of SEQ ID NO: 2 and has a function of degrading a nucleic acid molecule, a polypeptide that comprises the amino acid sequence of SEQ ID NO: 3 and has a function of degrading a nucleic acid molecule and a function of intranuclearly migrating the same, polynucleotides encoding the respective polypeptides, and transformed cells containing the respective polynucleotides.

IPC Classes  ?

  • C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

46.

ELECTROCHEMICAL SENSOR

      
Application Number 17766732
Status Pending
Filing Date 2020-10-07
First Publication Date 2023-07-27
Owner
  • Resonac Corporation (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Johmen, Masayoshi
  • Obata, Kazuhito
  • Setoguchi, Shinichi
  • Kawaguchi, Toshikazu
  • Ito, Ryusei
  • Guizani, Mokhtar

Abstract

An electrochemical sensor is used in a state of being immersed in water to be inspected for water quality inspection. The electrochemical sensor includes a working electrode, a reference electrode, a first counter electrode, and a second counter electrode. The working electrode, the reference electrode, the first counter electrode, and the second counter electrode are electrically isolated from each other.

IPC Classes  ?

47.

DEVELOPMENT OF BLOOD FIBROSIS MARKER FOR NON-ALCOHOLIC STEATOHEPATITIS

      
Application Number 17625856
Status Pending
Filing Date 2020-07-10
First Publication Date 2023-07-27
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Furukawa, Jun-Ichi
  • Sakamoto, Naoya
  • Hanamatsu, Hisatoshi
  • Ogawa, Koji
  • Suda, Goki

Abstract

A method for evaluating the progression of hepatic fibrosis in non-alcoholic steatohepatitis, said method comprising measuring the amount of a sugar chain having a structure represented by formula (I) and/or a precursor sugar chain of the biosynthesis of a sugar chain having a structure represented by formula (I) in a sample.

IPC Classes  ?

  • G01N 33/66 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

48.

HYDROGEN PERMEABLE MATERIAL

      
Application Number 17997392
Status Pending
Filing Date 2022-03-07
First Publication Date 2023-07-20
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor Aoki, Yoshitaka

Abstract

An object of the present invention is to provide a hydrogen permeable material having excellent hydrogen permeability. Another object of the present invention is to provide a composite member and a fuel cell including the hydrogen permeable material. The hydrogen permeable material comprises a perovskite type compound represented by the following general formula (1a). In another embodiment, the hydrogen permeable material comprises a hydrogen-containing perovskite type compound, which is the perovskite type compound represented by the general formula (1a) with introduced hydride ion (H−). Wherein M is at least one alkaline earth metal selected from the group consisting of Ba, Sr and Ca, x is a numerical value of 0 or more and 0.3 or less, y is a numerical value of more than 0 and 0.75 or less, w is a value at which an average valence of In is +1.0 or more and +2.5 or less, and y≥w. An object of the present invention is to provide a hydrogen permeable material having excellent hydrogen permeability. Another object of the present invention is to provide a composite member and a fuel cell including the hydrogen permeable material. The hydrogen permeable material comprises a perovskite type compound represented by the following general formula (1a). In another embodiment, the hydrogen permeable material comprises a hydrogen-containing perovskite type compound, which is the perovskite type compound represented by the general formula (1a) with introduced hydride ion (H−). Wherein M is at least one alkaline earth metal selected from the group consisting of Ba, Sr and Ca, x is a numerical value of 0 or more and 0.3 or less, y is a numerical value of more than 0 and 0.75 or less, w is a value at which an average valence of In is +1.0 or more and +2.5 or less, and y≥w. M1-xZr1-yInyO3-x-0.5y-2  (1a)

IPC Classes  ?

  • C01G 25/02 - Oxides
  • C01G 25/00 - Compounds of zirconium
  • H01M 8/1253 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides the electrolyte containing zirconium oxide
  • H01M 8/126 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides the electrolyte containing cerium oxide

49.

METHOD FOR DECOMPOSING COMPOUND AND COMPOUND

      
Application Number 17997347
Status Pending
Filing Date 2021-12-06
First Publication Date 2023-07-13
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Ogawa, Mikako
  • Takakura, Hideo
  • Matsuhiro, Shino
  • Inanami, Osamu

Abstract

A method for decomposing a compound represented by Formula (1) includes irradiating the compound with X-rays in a presence of an electron donor: A method for decomposing a compound represented by Formula (1) includes irradiating the compound with X-rays in a presence of an electron donor: A method for decomposing a compound represented by Formula (1) includes irradiating the compound with X-rays in a presence of an electron donor: wherein R111, R121, R131, and R141 each independently represent a monovalent organic group; p, q, r, and s each independently represent an integer of 0 or 1 to 4; in the case where two or more R111, R121, R131, and R141 are present, they may be identical to or different from one another or may be bonded to one another to form a ring; A101 represents a monovalent organic group; and A102 represents a hydrogen atom or a monovalent organic group). In the method, a photosensitive dye can be decomposed using an energy beam which can penetrate deeper into a living body than near-infrared light and activate the photosensitive dye.

IPC Classes  ?

  • A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

50.

ALUMINUM MEMBER AND MANUFACTURING METHOD THEREOF

      
Application Number 17927998
Status Pending
Filing Date 2021-06-11
First Publication Date 2023-07-06
Owner
  • National University Corporation Hokkaido University (Japan)
  • UACJ Corporation (Japan)
Inventor
  • Kikuchi, Tatsuya
  • Sato, Miu
  • Nunomura, Junji
  • Oya, Yoshiyuki

Abstract

An aluminum member (1) includes: a base material (2) composed of aluminum or an aluminum alloy; and an anodic oxide film (3) formed on a surface of the base material. The anodic oxide film includes: an amorphous layer (31), which is composed of an amorphous aluminum oxide and is formed on the base material (2); and a crystal layer (32), which is composed of a crystalline aluminum oxide and is formed on the amorphous layer (31). The aluminum member (1) can be obtained by forming the anodic oxide film (3) on the base material (2) by performing an anodization process on the base material (2) in an electrolytic solution, which contains boron atoms and has a pH of 7.0-12.0.

IPC Classes  ?

  • C25D 11/06 - Anodisation of aluminium or alloys based thereon characterised by the electrolytes used
  • C25D 11/14 - Producing integrally coloured layers

51.

COMPOSITION FOR CYTOTOXIC T LYMPHOCYTE (CTL) ACTIVATION

      
Application Number 18008698
Status Pending
Filing Date 2021-07-09
First Publication Date 2023-07-06
Owner
  • DIC Corporation (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Imai, Yasuyuki
  • Hirahashi, Tomohiro
  • Kasahara, Masanori
  • Miyazaki, Aya
  • Seya, Tsukasa
  • Matsumoto, Misako
  • Tomaru, Utano

Abstract

A composition for activating cytotoxic T lymphocytes (CTLs) containing a spirulina extract is provided. A composition for CTL activation for proliferation of cytotoxic T lymphocytes (CTLs) containing a spirulina extract is provided. Moreover, a pharmaceutical composition for CTL activation or a food or a drink for CTL activation containing the composition for CTL activation is provided.

IPC Classes  ?

  • A61K 35/748 - Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
  • A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
  • A61P 17/00 - Drugs for dermatological disorders
  • A61P 37/00 - Drugs for immunological or allergic disorders
  • A61P 35/00 - Antineoplastic agents

52.

Triazine derivatives having virus replication inhibitory activity and pharmaceutical composition comprising the same

      
Application Number 17733366
Grant Number 11814368
Status In Force
Filing Date 2022-04-29
First Publication Date 2023-07-06
Grant Date 2023-11-14
Owner
  • SHIONOGI & CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Tachibana, Yuki
  • Uehara, Shota
  • Unoh, Yuto
  • Nakahara, Kenji
  • Taoda, Yoshiyuki
  • Yamatsu, Yukiko
  • Ando, Shigeru
  • Sasaki, Michihito

Abstract

The present invention provides a compound exhibiting coronavirus 3 CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula: or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

  • C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • A61P 31/14 - Antivirals for RNA viruses
  • A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

53.

CATALYST STRUCTURE FOR SYNTHESIS GAS PRODUCTION, SYNTHESIS GAS PRODUCTION APPARATUS, AND METHOD FOR PRODUCING CATALYST STRUCTURE FOR SYNTHESIS GAS PRODUCTION

      
Application Number 18000459
Status Pending
Filing Date 2021-06-01
First Publication Date 2023-07-06
Owner
  • FURUKAWA ELECTRIC CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Banba, Yuichiro
  • Fukushima, Masayuki
  • Ueno, Takahiro
  • Mori, Tomohiko
  • Nishii, Mai
  • Masuda, Takao
  • Nakasaka, Yuta
  • Yoshikawa, Takuya

Abstract

A catalyst structure for synthesis gas production of a synthesis gas that contains carbon monoxide and hydrogen, the catalyst structure being provided with a carrier that has a porous structure, while being configured from a zeolite type compound; first catalyst particles that contain one or more iron group elements which are selected from the group consisting of nickel (Ni), iron (Fe) and cobalt (Co); and second catalyst particles that contain one or more platinum group elements which are selected from the group consisting of platinum (Pt), palladium (Pd), rhodium (Rh) and ruthenium (Ru). The catalyst structure for synthesis gas production has passages in communication with each other within the carrier. The first catalyst particles are present at least in the passages of the carrier; and the second catalyst particles are present at least either inside the carrier or on the outer surface of the carrier.

IPC Classes  ?

  • B01J 29/035 - Crystalline silica polymorphs, e.g. silicalites
  • B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
  • B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
  • B01J 35/10 - Solids characterised by their surface properties or porosity
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/08 - Heat treatment
  • B01J 37/16 - Reducing
  • C01B 3/40 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts characterised by the catalyst

54.

Functional structural body and method for making functional structural body

      
Application Number 18171140
Grant Number 12115523
Status In Force
Filing Date 2023-02-17
First Publication Date 2023-06-29
Grant Date 2024-10-15
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • FURUKAWA ELECTRIC CO., LTD. (Japan)
Inventor
  • Masuda, Takao
  • Nakasaka, Yuta
  • Yoshikawa, Takuya
  • Kato, Sadahiro
  • Fukushima, Masayuki
  • Inamori, Kojiro
  • Takahashi, Hiroko
  • Banba, Yuichiro
  • Sekine, Kaori

Abstract

To provide a functional structural body that can realize a long life time by suppressing the decline in function of the functional substance and that can attempt to save resources without requiring a complicated replacement operation, and to provide a method for making the functional structural body. The functional structural body (1) includes a skeletal body (10) of a porous structure composed of a zeolite-type compound, and at least one functional substance (20) present in the skeletal body (10), the skeletal body (10) has channels (11) connecting with each other, and the functional substance is present at least in the channels (11) of the skeletal body (10).

IPC Classes  ?

  • B01J 29/76 - Iron group metals or copper
  • B01J 29/035 - Crystalline silica polymorphs, e.g. silicalites
  • B01J 29/064 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof containing iron group metals, noble metals or copper
  • B01J 29/068 - Noble metals
  • B01J 29/072 - Iron group metals or copper
  • B01J 29/076 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/08 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y
  • B01J 29/10 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y containing iron group metals, noble metals or copper
  • B01J 29/12 - Noble metals
  • B01J 29/14 - Iron group metals or copper
  • B01J 29/16 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the faujasite type, e.g. type X or Y containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/18 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type
  • B01J 29/20 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type containing iron group metals, noble metals or copper
  • B01J 29/22 - Noble metals
  • B01J 29/24 - Iron group metals or copper
  • B01J 29/26 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the mordenite type containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/40 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
  • B01J 29/42 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11 containing iron group metals, noble metals or copper
  • B01J 29/44 - Noble metals
  • B01J 29/46 - Iron group metals or copper
  • B01J 29/48 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11 containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/60 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the type L
  • B01J 29/61 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the type L containing iron group metals, noble metals or copper
  • B01J 29/62 - Noble metals
  • B01J 29/63 - Iron group metals or copper
  • B01J 29/64 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the type L containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/65 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38
  • B01J 29/66 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38 containing iron group metals, noble metals or copper
  • B01J 29/67 - Noble metals
  • B01J 29/68 - Iron group metals or copper
  • B01J 29/69 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38 containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 29/70 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups
  • B01J 29/72 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups containing iron group metals, noble metals or copper
  • B01J 29/74 - Noble metals
  • B01J 29/78 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of types characterised by their specific structure not provided for in groups containing arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
  • B01J 35/23 - in a colloidal state
  • B01J 35/56 - Foraminous structures having flow-through passages or channels, e.g. grids or three-dimensional monoliths
  • B01J 35/64 - Pore diameter
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/03 - Precipitation; Co-precipitation
  • B01J 37/10 - Heat treatment in the presence of water, e.g. steam

55.

JAPANESE ENCEPHALITIS PREVENTIVE AGENT AND JAPANESE ENCEPHALITIS VACCINE AGENT

      
Application Number 18154575
Status Pending
Filing Date 2023-01-13
First Publication Date 2023-06-29
Owner
  • FUJIFILM Corporation (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Oyamada, Takayoshi
  • Shimada, Toshio
  • Kakita, Kosuke
  • Iwata, Hiroaki

Abstract

It is an object of the present invention to provide a Japanese encephalitis preventive agent and a Japanese encephalitis vaccine agent, which are capable of imparting sufficient immunity to humans, even if these agents are used at a lower dose than the dose of a Japanese encephalitis vaccine for subcutaneous injection, or at a smaller number of administrations than the number of administrations of a Japanese encephalitis vaccine for subcutaneous injection. According to the present invention, provided is a Japanese encephalitis preventive agent, comprising a microneedle array having a sheet portion and a plurality of needle portions present on the upper surface of the sheet portion, wherein the aforementioned needle portions contain or carry an inactivated Japanese encephalitis virus.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 39/12 - Viral antigens
  • A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
  • A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

56.

ROD GROUP, ARCUATE ROD, S-SHAPED ROD, SPINE STABILIZATION SYSTEM, AND ROD MANUFACTURING METHOD

      
Application Number 18113181
Status Pending
Filing Date 2023-02-23
First Publication Date 2023-06-22
Owner
  • National University Corporation Hokkaido University (Japan)
  • Robert Reid, Inc. (Japan)
Inventor
  • Sudo, Hideki
  • Kanai, Satoshi
  • Kokabu, Terufumi
  • Abe, Yuichiro
  • Segawa, Tsuyoshi

Abstract

A rod group includes a plurality of first rods that has an arcuate first curve, the first rods having mutually different lengths; and a plurality of second rods that has an S-shaped second curve, the second rods having mutually different lengths. The first rods and the second rods have shapes for treatment of scoliosis by (i) guiding the postoperative apex of the thoracic kyphosis to be located at the thoracic vertebrae T6 to T8, and (ii) guiding a postoperative apex of the thoracic kyphosis to be located at a position different from a preoperative apex of the thoracic kyphosis and the second rod each have a shape extending along an anatomically normal spinal column arrangement.

IPC Classes  ?

57.

PARENT-AND-CHILD HEALTH STUDY ASSISTANCE SYSTEM, PARENT-AND-CHILD HEALTH STUDY ASSISTANCE APPARATUS, AND DATA PROCESSING METHOD

      
Application Number 17917056
Status Pending
Filing Date 2021-03-12
First Publication Date 2023-06-15
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • MORINAGA MILK INDUSTRY CO., LTD. (Japan)
  • Hitachi, Ltd. (Japan)
Inventor
  • Suzuki, Daisuke
  • Lei, Miaomei
  • Tamakoshi, Akiko
  • Yokota, Takashi
  • Nakamura, Kiminori
  • Takeda, Yasuhiro
  • Ehara, Tatsuya

Abstract

A parent-and-child health study assistance system includes a data management section managing health study data used for a health study of at least one of a parent and a child in a family including a user as a family member, a level calculation section calculating a contribution level for the health study of the user based on input of the health study data, an incentive provision section providing the user with an incentive used as a profit corresponding to the contribution level, in conjunction with input of the health study data, an access control section managing an access authority to access the health study data, and an analysis result provision section providing an analysis result of analysis processing using the health study data.

IPC Classes  ?

  • G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
  • G06Q 30/0208 - Trade or exchange of goods or services in exchange for incentives or rewards
  • G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

58.

TREATMENT DEVICE

      
Application Number 18052100
Status Pending
Filing Date 2022-11-02
First Publication Date 2023-06-08
Owner
  • J. MORITA MFG. CORP. (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Sugaya, Tsutomu
  • Yamada, Keita
  • Ban, Shingo
  • Dokai, Kei
  • Ueda, Tomoaki
  • Yamaguchi, Shunsuke
  • Matoba, Kazunari

Abstract

A treatment device that shortens the time period until healing is determined even when a bone defect or a root apex lesion is generated in an apical area. The treatment device includes a file holder, a high-frequency signal generating circuit, and a control circuit. The file holder holds a file to be located in the site to be treated. The high-frequency signal generating circuit passes a high frequency current through the file. The control circuit controls a frequency of the high frequency current to be passed through the file from the high-frequency signal generating circuit. The control circuit controls the frequency of the high frequency current to be passed through the file within a range of 1.001 MHz to 11.700 MHz.

IPC Classes  ?

  • A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
  • A61N 1/06 - Electrodes for high-frequency therapy
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61C 5/40 - Implements for surgical treatment of the roots or nerves of the teeth; Nerve needles; Methods or instruments for medication of the roots

59.

OXIDE-CONTAINING COPPER FINE PARTICLES, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING SINTERED COMPACT USING OXIDE-CONTAINING COPPER FINE PARTICLES

      
Application Number 17921447
Status Pending
Filing Date 2021-08-26
First Publication Date 2023-06-08
Owner National University Corporation Hokkaido University (Japan)
Inventor Yonezawa, Tetsu

Abstract

Disclosed is oxide-containing copper fine particles including Cu64O and optionally Cu2O and coated with a carboxylic acid, wherein a mass ratio of Cu64O to a total mass of Cu, Cu64O and Cu2O is 0.5 to 2.0% by mass.

IPC Classes  ?

  • B22F 1/102 - Metallic powder coated with organic material
  • B22F 9/04 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from solid material, e.g. by crushing, grinding or milling
  • B22F 7/04 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite layers with one or more layers not made from powder, e.g. made from solid metal

60.

Method for Producing Mono-Cross-Coupled Aromatic Compound Having Leaving Group

      
Application Number 17908197
Status Pending
Filing Date 2021-03-02
First Publication Date 2023-05-18
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Ito, Hajime
  • Kubota, Koji

Abstract

Disclosed is a method for producing a mono-cross-coupled aromatic compound (3-1) having one less leaving group than an aromatic compound (1) having at least two leaving groups, the method comprising: preparing the aromatic compound (1) having at least two leaving groups; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic boronic acid (2-1), an aromatic amino compound (2-2), a diboronic acid ester (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the aromatic compound (1) having at least two leaving groups with the compound (2) in the presence of a palladium catalyst and a base, in the absence of a solvent.

IPC Classes  ?

  • C07C 209/68 - Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
  • C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
  • C07C 17/263 - Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
  • C07C 1/30 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero atoms by splitting-off the elements of hydrogen halide from a single molecule
  • C07C 17/269 - Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions of only halogenated hydrocarbons
  • C07D 333/16 - Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
  • C07D 333/22 - Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
  • C07D 333/56 - Radicals substituted by oxygen atoms
  • C07C 1/32 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero atoms other than, or in addition to, oxygen or halogen

61.

PARENT-CHILD HEALTH MANAGEMENT SYSTEM, PARENT-CHILD HEALTH ANALYSIS DEVICE, AND PARENT-CHILD HEALTH MANAGEMENT METHOD

      
Application Number 17910935
Status Pending
Filing Date 2021-03-12
First Publication Date 2023-05-11
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • MORINAGA MILK INDUSTRY CO., LTD. (Japan)
  • Hitachi, Ltd. (Japan)
Inventor
  • Nakamura, Takahiro
  • Takemoto, Takashi
  • Yoshino, Masanori
  • Ayabe, Tokiyoshi
  • Kimura, Takashi
  • Izumi, Hirohisa
  • Tabata, Fuka

Abstract

An analysis device in a parent-child health management system receives a sensor output from a sensor terminal and an answer to a questionnaire from a user terminal. At least one of parent's life information and child's life information is analyzed based on the answer to the questionnaire to generate a life information analysis result. A sensor output analysis unit generates, based on the sensor output, a sensing result including at least one of a parent-child relationship, a parent's health condition, and a child's health condition. A health estimation unit is configured to compare the life information analysis result and the sensing result with a predetermined criterion to estimate at least one of a parent-child state, a parent's state, and a child's state. An output unit is configured to select a questionnaire and advice corresponding to the estimated state and output the selected questionnaire and advice to the user terminal.

IPC Classes  ?

  • G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires

62.

LIPID MEMBRANE STRUCTURE FOR DELIVERY INTO SIRNA CELL

      
Application Number 17989260
Status Pending
Filing Date 2022-11-17
First Publication Date 2023-05-04
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Harashima, Hideyoshi
  • Sato, Yusuke

Abstract

A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): [in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R1 and R2 each independently represents a linear hydrocarbon group that may have —CO—O—; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R3 and R4 each independently represents a C1-4 alkyl group or a C2-4 alkenyl group, where, R3 and R4 may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C1-4 alkyl groups or C2-4 alkenyl groups may be substituted on the ring)].

IPC Classes  ?

  • A61K 9/127 - Liposomes
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • C07D 211/32 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
  • C07D 295/03 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms

63.

FOOD ANIMAL FRESHNESS/DEGREE OF MATURATION EVALUATING DEVICE, AND FRESHNESS/DEGREE OF MATURATION EVALUATING METHOD

      
Application Number 17909459
Status Pending
Filing Date 2021-03-05
First Publication Date 2023-04-27
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Inada, Takaaki
  • Nagaishi, Hiroshi
  • Tsubouchi, Naoto
  • Shinohara, Yuji

Abstract

A freshness/degree of maturation evaluating device for evaluating freshness and/or degree of maturation of food animal, freshness/degree of maturation evaluating device provided with: temperature parameter calculation unit that calculates temperature parameter regarding storage time and temperature in arbitrary area inside food animal, parameter based on temperature in arbitrary area inside food animal, determined by storage time and unsteady heat conduction equation; rate constant parameter calculation unit that calculates rate constant parameter regarding sequential decomposition reactions of various ATP-associated compounds contained infood animal, parameter being set based on rate constants in food animal determined by using relation based on storage time of food animal and measured values of ATP-associated compound concentrations; ATP-associated compound concentration calculation unit that calculates ATP-associated compound concentrations by sequential decomposition reaction calculation model using temperature parameter and rate constant parameter; and freshness/degree of maturation evaluation unit that computes K value and/or FI value from ATP-associated compound concentrations.

IPC Classes  ?

  • G01N 33/12 - Meat; Fish
  • A23B 4/06 - Freezing; Subsequent thawing; Cooling
  • A22B 5/00 - Accessories for use during or after slaughtering
  • A22C 29/00 - Processing shellfish, e.g. oysters, lobsters

64.

TRIAZINE DERIVATIVES HAVING VIRUS REPLICATION INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

      
Application Number 17790358
Status Pending
Filing Date 2022-02-17
First Publication Date 2023-04-27
Owner
  • Shionogi & Co., Ltd. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Tachibana, Yuki
  • Uehara, Shota
  • Unoh, Yuto
  • Nakahara, Kenji
  • Taoda, Yoshiyuki
  • Kasamatsu, Koji
  • Yamatsu, Yukiko
  • Ando, Shigeru
  • Iimuro, Atsuhiro
  • Suto, Takahiro
  • Sasaki, Michihito

Abstract

The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula (I): The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula (I): wherein Y is N or the like; R1 is substituted or unsubstituted aromatic heterocyclyl or the like; R2 is substituted or unsubstituted aromatic carbocyclyl or the like; R3 is substituted or unsubstituted aromatic heterocyclyl or the like; —X— is —NH— or the like; m is 1 or the like; R5a is each independently a hydrogen atom or the like; R5b is each independently a hydrogen atom or the like; n is 1 or the like; R4a is each independently a hydrogen atom or the like; and R4b is each independently a hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
  • C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
  • C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
  • C07D 471/04 - Ortho-condensed systems
  • C07D 495/04 - Ortho-condensed systems
  • C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 498/04 - Ortho-condensed systems
  • A61P 31/14 - Antivirals for RNA viruses
  • C07D 487/04 - Ortho-condensed systems

65.

MOTHER AND CHILD HEALTH MANAGEMENT SYSTEM AND INFORMATION PROVISION METHOD

      
Application Number 17910885
Status Pending
Filing Date 2021-03-12
First Publication Date 2023-04-20
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • MORINAGA MILK INDUSTRY CO., LTD. (Japan)
  • Hitachi, Ltd. (Japan)
Inventor
  • Nakamura, Takahiro
  • Takemoto, Takashi
  • Yoshino, Masanori
  • Ayabe, Tokiyoshi
  • Kimura, Takashi
  • Izumi, Hirohisa
  • Tabata, Fuka

Abstract

A mother and child health management system is connected to a plurality of terminals and includes: a reception unit configured to receive, as analysis information, information from each of the plurality of terminals and biological information from a medical care institution; a classification unit configured to identify, based on an analysis result of the analysis information, state values indicating a state of a mother, a state of a child, and a state between the mother and the child; an access authority management section configured to identify, based on each of the state values, a community to which a family including a user of the each of the plurality of terminals belongs, and configured to provide the terminal with an access authority to receive a display of a solution related to the community; and a display unit configured to display the solution related to the community on the terminal.

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

66.

Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative

      
Application Number 17957103
Grant Number 12098151
Status In Force
Filing Date 2022-09-30
First Publication Date 2023-04-20
Grant Date 2024-09-24
Owner
  • NATIONAL UNIVERSITY COPORATION HOKKAIDO UNIVERSITY (Japan)
  • SHIONOGI & CO., LTD. (Japan)
Inventor
  • Ishii, Akihiro
  • Sato, Akihiko
  • Kawai, Makoto
  • Taoda, Yoshiyuki

Abstract

The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound. An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof: 11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
  • A61P 31/14 - Antivirals for RNA viruses
  • C07D 471/14 - Ortho-condensed systems
  • C07D 498/14 - Ortho-condensed systems

67.

AGENT FOR PROTECTION OF BLOOD BRAIN SPINAL CORD BARRIER

      
Application Number 17642287
Status Pending
Filing Date 2021-06-24
First Publication Date 2023-04-06
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Kadoya, Ken
  • Suzuki, Yuki
  • Sotome, Akihito
  • Maenaka, Katsumi
  • Otsuguro, Satoko

Abstract

The present invention relates to an agent for protection of vascular endothelial cells, an agent for protection of blood brain spinal cord barrier, and an agent for protection of central nervous system, containing at least one compound selected from the group consisting of muvritinib, brexpiprazole, papaverine, bismuth-containing compounds, and pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical composition for the treatment of diseases associated with blood brain spinal cord barrier disruption, containing at least one compound selected from the group consisting of muvritinib, brexpiprazole, papaverine, bismuth-containing compounds, and pharmaceutically acceptable salts thereof.

IPC Classes  ?

  • A61K 31/29 - Antimony or bismuth compounds
  • A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
  • A61K 31/4192 - 1,2,3-Triazoles
  • A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine
  • A61P 39/00 - General protective or antinoxious agents

68.

DISSOLVING AGENT

      
Application Number 17760269
Status Pending
Filing Date 2021-02-12
First Publication Date 2023-04-06
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION (Japan)
Inventor
  • Harashima, Hideyoshi
  • Sato, Yusuke
  • Abbasi, Saed Amjad Yousef
  • Yamashita, Shinji
  • Higashino, Haruki

Abstract

The present invention addresses the problem of providing a dissolving agent which improves the solubility of a compound such as curcumin that contains an aromatic ring without changing the structure of this compound. The present invention is a compound which is represented by general formula (1). (In the formula, R1 is an alkyl group having 7 to 24 carbon atoms or an alkenyl group; A1 represents an optionally substituted aryl group; Z1 represents a single bond, an alkylene group having from 1 to 6 carbon atoms, or an alkenylene group having from 2 to 5 carbon atoms; and Z2 represents a divalent linking group.) The present invention addresses the problem of providing a dissolving agent which improves the solubility of a compound such as curcumin that contains an aromatic ring without changing the structure of this compound. The present invention is a compound which is represented by general formula (1). (In the formula, R1 is an alkyl group having 7 to 24 carbon atoms or an alkenyl group; A1 represents an optionally substituted aryl group; Z1 represents a single bond, an alkylene group having from 1 to 6 carbon atoms, or an alkenylene group having from 2 to 5 carbon atoms; and Z2 represents a divalent linking group.)

IPC Classes  ?

  • A61K 9/08 - Solutions
  • A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

69.

STABLE EQUIVALENT OF RESOLVIN E2

      
Application Number 17799953
Status Pending
Filing Date 2021-02-18
First Publication Date 2023-03-30
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Shuto, Satoshi
  • Matsuda, Tadashi
  • Muromoto, Ryuta
  • Fukuda, Hayato

Abstract

The present invention provides a compound represented by General Formula (1) or (1′) [in the formula, R1 and R2 each independently represents a hydrogen atom or a hydroxy group; R3 represents an alkyl group having 1 to 6 carbon atoms; R4 represents a halogen atom or an alkyl group; m indicates the number of R4 and represents an integer of 0 to 4; in a case where m is 2 or more, a plurality of R4's may be the same or different from each other; n represents an integer of 1 to 6; and n′ represents an integer of 1 to 4] and a neutrophil infiltration suppressor containing the compound as an active ingredient. The present invention provides a compound represented by General Formula (1) or (1′) [in the formula, R1 and R2 each independently represents a hydrogen atom or a hydroxy group; R3 represents an alkyl group having 1 to 6 carbon atoms; R4 represents a halogen atom or an alkyl group; m indicates the number of R4 and represents an integer of 0 to 4; in a case where m is 2 or more, a plurality of R4's may be the same or different from each other; n represents an integer of 1 to 6; and n′ represents an integer of 1 to 4] and a neutrophil infiltration suppressor containing the compound as an active ingredient.

IPC Classes  ?

  • C07C 57/30 - Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

70.

OPTICAL FILTER AND WAVELENGTH TUNABLE LASER ELEMENT

      
Application Number 17942612
Status Pending
Filing Date 2022-09-12
First Publication Date 2023-03-23
Owner
  • Sumitomo Electric Industries, Ltd. (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Hiratani, Takuo
  • Fujiwara, Naoki
  • Saitoh, Kunimasa
  • Fujisawa, Takeshi
  • Sato, Takanori

Abstract

An optical filter includes a first loop mirror, a second loop mirror, a first waveguide optically coupled to the first loop mirror and the second loop mirror, a second waveguide optically coupled to the first loop mirror and the second loop mirror, a first access waveguide optically coupled to the first waveguide, a second access waveguide optically coupled to the second waveguide, and an output section, wherein the first loop mirror includes a first loop waveguide and a first multiplexer/demultiplexer, the second loop mirror includes a second loop waveguide and a second multiplexer/demultiplexer, the output section includes a third loop waveguide, a third multiplexer/demultiplexer, a third waveguide, and a fourth waveguide, the third loop waveguide optically coupled to the second loop waveguide and the third multiplexer/demultiplexer, the third waveguide and the fourth waveguide optically coupled to the third multiplexer/demultiplexer, and the output section.

IPC Classes  ?

  • G02B 5/26 - Reflecting filters
  • G02B 6/12 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind

71.

RARE EARTH COMPLEX

      
Application Number 17788530
Status Pending
Filing Date 2020-12-23
First Publication Date 2023-03-23
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kitagawa, Yuichi
  • Naito, Ayu
  • Hasegawa, Yasuchika
  • Fushimi, Koji

Abstract

Disclosed is a rare earth complex including: one or a plurality of rare earth ions; and a ligand forming a coordinate bond with the rare earth ions. At least a part of the rare earth ions are at least one kind selected from the group consisting of lutetium(III) ions, yttrium(III) ions, and gadolinium(III) ions. The ligand includes a residue obtained by removing one or more hydrogen atoms from a fluorescent condensed polycyclic aromatic compound.

IPC Classes  ?

  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
  • C07F 9/53 - Organo-phosphine oxides; Organo-phosphine sulfides

72.

BLOCK COPOLYMER AND METHOD FOR PRODUCING SAME

      
Application Number 17802772
Status Pending
Filing Date 2021-02-26
First Publication Date 2023-03-23
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Matsumoto, Kenichiro
  • Fukui, Toshiaki
  • Ishihara, Shizuru

Abstract

A copolymer comprising: a hydroxycarboxylic acid (A) having a hydroxy group only at a 2-position; and a hydroxycarboxylic acid (B) having a hydroxy group at a position other than a 2-position, and having a homopolymer segment composed of one hydroxycarboxylic acid selected from the group consisting of the hydroxycarboxylic acid (A) and the hydroxycarboxylic acid (B), and a copolymer segment containing at least two hydroxycarboxylic acids selected from the group consisting of the hydroxycarboxylic acid (A) and the hydroxycarboxylic acid (B).

IPC Classes  ?

  • C08G 63/06 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxy carboxylic acids

73.

CARTILAGE DAMAGE TREATMENT MATERIAL UTILIZING BONE MARROW FLUID

      
Application Number 17792076
Status Pending
Filing Date 2021-01-15
First Publication Date 2023-03-16
Owner
  • National University Corporation Hokkaido University (Japan)
  • Mochida Pharmaceutical Co., Ltd. (Japan)
Inventor
  • Iwasaki, Norimasa
  • Onodera, Tomohiro
  • Urita, Atsushi
  • Jo, Ryo

Abstract

Provided is a composition for treating cartilage injury lesion that is combined with a concentrated bone marrow aspirate and applied to a cartilage injury lesion, that has flowability when applied to the cartilage injury lesion, and that contains a monovalent metal salt of alginic acid. Thereby, a novel composition for treating cartilage injury lesion that can be used to restore and/or regenerate cartilage tissue is provided.

IPC Classes  ?

  • A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
  • A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
  • A61K 31/734 - Alginic acid

74.

METHOD FOR ASSISTING DETECTION OF NON-ALCOHOLIC STEATOHEPATITIS

      
Application Number 17797284
Status Pending
Filing Date 2021-02-04
First Publication Date 2023-03-02
Owner
  • Denka Company Limited (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (Japan)
Inventor
  • Satoh, Noriyuki
  • Ito, Yasuki
  • Sakurai, Toshihiro
  • Mizuta, Masahiro
  • Hui, Shu-Ping
  • Nouso, Kazuhiro
  • Okada, Hiroyuki

Abstract

Provided is a method of assisting the detection of nonalcoholic steatohepatitis (NASH), which is far less invasive than liver biopsy and is based on simple operations that do not require skilled technical personnel. Provided is a method of assisting the detection of nonalcoholic steatohepatitis (NASH), which is far less invasive than liver biopsy and is based on simple operations that do not require skilled technical personnel. The present invention is a method of assisting the detection of NASH, which includes: a) measuring the amount of LDL-TG contained in a test blood sample isolated from a living body; b) measuring the amount of at least one component selected from the group consisting of LDL-C, LDL subfraction-C, IIDL-C, HDL subfraction-C, ApoB, ApoE, total cholesterol, ALT, and AST contained in the test blood sample; and c) determining the possibility of developing and/or having NASH by using the amount of LDL-TG in combination with the amount of the at least one component.

IPC Classes  ?

  • G01N 33/92 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol
  • C12Q 1/60 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol

75.

PROTON CONDUCTIVE MATERIAL

      
Application Number 17816736
Status Pending
Filing Date 2022-08-02
First Publication Date 2023-03-02
Owner
  • TOYOTA JIDOSHA KABUSHIKI KAISHA (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Nakamura, Naoki
  • Nakano, Tamaki

Abstract

To provide a proton conductive material which has high proton conductivity even under no humidification and does not elute into water. A proton conductive material comprising a proton-source-polymer and a proton-channel-polymer, wherein at least one selected from the group consisting of the proton-source-polymer and the proton-channel-polymer is a polymer containing an aromatic ring, and wherein at least a part of the polymer containing the aromatic ring has a stacked structure formed by n-n interactions, and a proton conductive material comprising a proton-source-crosslinked-polymer, wherein the proton-source-crosslinked-polymer is a polymer having a main skeleton which contains a proton source group and an aromatic ring, and a crosslinked structure which contains a proton channel, and wherein at least a part of the proton-source-crosslinked-polymer has a stacked structure formed by n-n interactions.

IPC Classes  ?

  • C08L 81/06 - Polysulfones; Polyethersulfones
  • C08L 25/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
  • C08L 79/02 - Polyamines
  • H01M 8/1032 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having sulfur, e.g. sulfonated-polyethersulfones [S-PES]
  • H01M 8/1039 - Polymeric electrolyte materials halogenated, e.g. sulfonated polyvinylidene fluorides

76.

COMBINATION AND METHOD FOR TREATING SUBJECT USING ALGINATE

      
Application Number 17792099
Status Pending
Filing Date 2021-01-13
First Publication Date 2023-02-16
Owner
  • MOCHIDA PHARMACEUTICAL CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Takai, Tomokazu
  • Mizuno, Hitoshi
  • Takahashi, Akira
  • Endo, Toshiya
  • Sakaue, Shinichi
  • Iwasaki, Norimasa
  • Onodera, Tomohiro
  • Iwasaki, Koji

Abstract

Realized is reliable fixation of a material in a fluid state containing a monovalent metal salt of alginic acid when the material is applied to a subject. A combination of compositions comprising a first material composition containing a monovalent metal salt of alginic acid and a second material composition containing a cross-linking agent having an action of cross-linking the monovalent metal salt of alginic acid, wherein the combination is to be used in such a way as to apply the first material composition to a subject in a fluid state and contact the second material composition with the first material composition applied to the subject to gel at least a part of the first material composition, wherein the first material composition further contains a coloring component so that a formation state of a gel coat on a surface of the first material composition applied to the subject can be evaluated.

IPC Classes  ?

77.

OPTICAL FILTER, WAVELENGTH TUNABLE LASER ELEMENT, WAVELENGTH TUNABLE LASER MODULE, METHOD OF CONTROLLING WAVELENGTH TUNABLE LASER MODULE, AND COMPUTER-READABLE NON-TRANSITORY MEDIUM

      
Application Number 17860301
Status Pending
Filing Date 2022-07-08
First Publication Date 2023-02-09
Owner
  • SUMITOMO ELECTRIC INDUSTRIES, LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kono, Naoya
  • Fujiwara, Naoki
  • Saitoh, Kunimasa
  • Fujisawa, Takeshi
  • Sato, Takanori

Abstract

An optical filter includes a first loop mirror, a second loop mirror, a first waveguide optically coupled to the first loop mirror and the second loop mirror, and a first access waveguide. The first loop mirror includes a first loop waveguide and a first multiplexer/demultiplexer. The second loop mirror includes a second loop waveguide and a second multiplexer/demultiplexer. The first loop waveguide is optically coupled to the first multiplexer/demultiplexer. The second loop waveguide is optically coupled to the second multiplexer/demultiplexer. The first waveguide is optically coupled to the first multiplexer/demultiplexer and the second multiplexer/demultiplexer. The first access waveguide is optically coupled to the first waveguide.

IPC Classes  ?

  • H01S 5/0687 - Stabilising the frequency of the laser
  • H01S 5/10 - Construction or shape of the optical resonator
  • H01S 5/026 - Monolithically integrated components, e.g. waveguides, monitoring photo-detectors or drivers

78.

RETRACTOR

      
Application Number 17792028
Status Pending
Filing Date 2021-01-13
First Publication Date 2023-02-09
Owner
  • MOCHIDA PHARMACEUTICAL CO., LTD. (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Mizuno, Hitoshi
  • Masuda, Kuniyoshi
  • Katayama, Masahiko
  • Takai, Tomokazu
  • Endo, Toshiya
  • Iwasaki, Norimasa
  • Onodera, Tomohiro
  • Iwasaki, Koji

Abstract

A retractor is provided that can form a joint cavity internal space for a field of view for an endoscope and practice of a treatment in a state where a wound area is spread. A retractor includes first arm portions 2 and 3 and a second arm portion 4 positioned between the first arm portions 2 and 3. The first arm portions 2 and 3 include first claw portions 12 and 13 to be hung on a wound area entrance edge. The second arm portion 4 includes a second claw portion 14 to be hung on the wound area entrance edge. When the first arm portions 2 and 3 and the second arm portion 4 are in a closed state, the first claw portions 12 and 13 and the second claw portion 14 overlap with each other.

IPC Classes  ?

  • A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors

79.

SOLANACEOUS PLANT AND SOLANACEOUS PLANT CELL HAVING RESISTANCE TO TOMATO SPOTTED WILT VIRUS, AND METHOD FOR PRODUCING SOLANACEOUS PLANT

      
Application Number 17788160
Status Pending
Filing Date 2020-12-07
First Publication Date 2023-02-02
Owner
  • KIKKOMAN CORPORATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Atarashi, Hiroki
  • Nakahara, Kenji

Abstract

The present invention addresses the problem of providing: a solanaceous plant and a solanaceous plant cell that have resistance to tomato spotted wilt virus (TSWV) and that have the property of inhibiting TSWV infection, the property of suppressing the propagation proliferation of TSWV after infection, and/or the property of suppressing the onset of the symptoms of TSWV infection; and a method for producing the solanaceous plant. The present invention provides a solanaceous plant that has resistance to TSWV, in which at least one gene selected from the group consisting of receptor-like kinase RLK genes and homologous genes thereof has a mutation, and in which as a result of the mutation, either the expression of the gene having the mutation is suppressed or a protein encoded by the gene having the mutation is non-functional with respect to TSWV.

IPC Classes  ?

  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

80.

CATALYST, METHOD FOR PRODUCING ISOBUTYL ALDEHYDE AND METHACROLEIN, METHOD FOR PRODUCING METHACRYLIC ACID, AND METHOD FOR PRODUCING METHACRYLIC ACID ESTER

      
Application Number 17930920
Status Pending
Filing Date 2022-09-09
First Publication Date 2023-01-19
Owner
  • Mitsubishi Chemical Corporation (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Suzuki, Tatsuya
  • Katou, Yuuki
  • Ninomiya, Wataru
  • Masuda, Takao
  • Nakasaka, Yuta
  • Yoshikawa, Takuya
  • Yamashita, Shohei

Abstract

There is provided a catalyst having an average electronegativity of 2.1 or more and 2.8 or less.

IPC Classes  ?

  • B01J 21/04 - Alumina
  • B01J 21/06 - Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
  • B01J 21/10 - Magnesium; Oxides or hydroxides thereof
  • B01J 23/06 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of zinc, cadmium or mercury
  • B01J 23/50 - Silver
  • B01J 23/04 - Alkali metals
  • B01J 37/08 - Heat treatment
  • C07C 29/153 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used

81.

METHOD FOR ASSESSING POSSIBILITY OF ONSET OR PROGRESSION OF CHRONIC KIDNEY ALLOGRAFT REJECTION AND CHRONIC KIDNEY DISEASE, TEST KIT, AND PHARMACEUTICAL COMPOSITION

      
Application Number 17642839
Status Pending
Filing Date 2021-02-01
First Publication Date 2022-12-08
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Murakami, Masaaki
  • Kamimura, Daisuke
  • Takada, Yusuke

Abstract

The present invention provides a method for assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease in a test subject, by using, as an indicator, the level of SYT17 protein in a urine-derived specimen collected from the test subject. The present invention also provides: a pharmaceutical composition for preventing and/or treating chronic kidney allograft rejection or chronic kidney disease, the pharmaceutical composition including at least one substance selected from the group consisting of a specific antibody to SYT17, a derivative of the specific antibody, and an inhibitory nucleic acid against SYT17; and a test kit for use in assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease, the test kit including a specific antibody to SYT17 or a derivative of the specific antibody.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
  • A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

82.

METHOD FOR SCREENING ANTICANCER AGENT AND COMBINATION DRUG OF KINASE INHIBITORS FOR TREATMENT OF PANCREATIC CANCER

      
Application Number 17635820
Status Pending
Filing Date 2021-03-01
First Publication Date 2022-12-08
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Sonoshita, Masahiro
  • Sekiya, Sho
  • Hirano, Satoshi

Abstract

The present invention relates to a method for screening an anticancer agent by causing drosophila having the characteristics of a) expression of mutant Ras85D, b) deletion or suppressed expression of a p53 gene, c) overexpression of a cyclin E gene, and d) deletion or suppressed expression of a Med gene to ingest a test substance and comparing the survival rate thereof with the survival rate of drosophila that did not ingest the test substance. The present invention also relates to a combination drug of at least two kinase inhibitors for treatment of pancreatic cancer and to kinase inhibitors for use in said combination drug.

IPC Classes  ?

  • A61K 49/00 - Preparations for testing in vivo
  • A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
  • A61P 35/00 - Antineoplastic agents
  • A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
  • A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
  • A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

83.

LATENT HEAT STORAGE BODY MICROCAPSULE AND METHOD FOR PRODUCING SAME

      
Application Number 17753297
Status Pending
Filing Date 2020-08-27
First Publication Date 2022-12-01
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Nomura, Takahiro
  • Kashiyama, Kohei
  • Sakai, Hiroki
  • Haga, Miki
  • Cho, Shunsuke
  • Sheng, Nan
  • Kawaguchi, Takahiro

Abstract

A latent heat storage body microcapsule includes a core including gallium or gallium alloy; and a shell covering the core and including gallium oxide. A method for producing the same includes a particle-forming step of forming gallium or an alloy of gallium in a liquid state into particles; a water treatment step of heating the particles in distilled water to form a gallium hydrate on a surface of each of the particles; and an oxidation treatment step of oxidizing the gallium hydrate to form a shell including gallium oxide. The method includes a particle-forming step of forming gallium or an alloy of gallium in a liquid state into particles; a cooling step of cooling the particles to a solid state; and a pH treatment step of immersing the particles in an aqueous solution having a predetermined pH to form a shell including gallium hydrate.

IPC Classes  ?

  • C09K 5/06 - Materials undergoing a change of physical state when used the change of state being from liquid to solid or vice-versa
  • B22F 1/16 - Metallic particles coated with a non-metal
  • B22F 1/145 - Chemical treatment, e.g. passivation or decarburisation

84.

THREE-DIMENSIONAL FLOW PATH STRUCTURE BODY AND NANOPARTICLE PRODUCTION METHOD USING SAME

      
Application Number 17765893
Status Pending
Filing Date 2019-10-04
First Publication Date 2022-11-24
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Maeki, Masatoshi
  • Tokeshi, Manabu
  • Harashima, Hideyoshi
  • Sato, Yusuke
  • Kimura, Niko

Abstract

The present invention pertains to a flow path structure body for forming self-assembling molecular particles. The flow path structure body has a base body and a flow path structure provided to the interior thereof, the flow path structure having a first introduction channel 10 and a second introduction channel 20 that are independent of one another on the upstream side of the flow path structure, and the introduction channels merging at a merging site. The flow path structure has a dilution flow path 40 that is bent three-dimensionally toward the downstream side of the merging site. The dilution flow path 40 has two or more Y structural elements 50 that protrude out in the Y direction and one or more Z structural elements 60 that protrude out in the Z direction within the dilution flow path, and at least two adjacent Y structural elements protrude out alternately in the Y direction. The present invention pertains to a method of producing self-assembling molecular particles, whereby a self-assembling molecule-containing solution and a dilution medium are supplied to the flow path structure body to form self-assembling molecular particles that have encapsulated a substance to be encapsulated. The present invention provides: a method of producing self-assembling molecular nanoparticles that enables precise control of the particle size of self-assembling molecular nanoparticles that have encapsulated an anionic molecule or the like at a high encapsulation rate; and a flow path structure body used for production.

IPC Classes  ?

  • A61K 9/127 - Liposomes
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying

85.

COMPOSITION FOR REMOVING PLURIPOTENT STEM CELLS AND METHOD OF REMOVING PLURIPOTENT STEM CELLS

      
Application Number 17414511
Status Pending
Filing Date 2019-12-19
First Publication Date 2022-11-17
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor Kondo, Toru

Abstract

An object is to provide a composition and a method for eliminating undifferentiated pluripotent stem cells remaining in a cell group induced to differentiate from pluripotent stem cells. It has been found that while dihydroorotate dehydrogenase inhibitors exhibit cytotoxic activity against pluripotent stem cells, they do not exhibit significant cytotoxic activity against differentiated cells such as somatic stem cells.

IPC Classes  ?

  • C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
  • C12N 5/0797 - Stem cells; Progenitor cells
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

86.

METHOD AND KIT FOR DETECTING HUMAN a-DEFENSIN HD5, AND ANTIBODIES USED IN SAID METHOD AND KIT

      
Application Number 17632995
Status Pending
Filing Date 2021-01-22
First Publication Date 2022-11-10
Owner National University Comoration Hokkaido University (Japan)
Inventor
  • Ayabe, Tokiyoshi
  • Nakamura, Kiminori

Abstract

The purpose of the present invention is to provide a method for detecting, in a selective and simple manner, an oxidized form of HD5 which is human α-defensin, that is, HD5 having intramolecular disulfide bonds that function beneficially in the human body. The purpose of the present invention is to provide a method for detecting, in a selective and simple manner, an oxidized form of HD5 which is human α-defensin, that is, HD5 having intramolecular disulfide bonds that function beneficially in the human body. [Solution] The present invention relates to: two kinds of novel monoclonal antibodies that contain amino acid sequences of SEQ ID NO: 1-6 or 7-12 as a CDR and that specifically bind to human α-defensin HD5 having intramolecular disulfide bonds; an immunological detection method using the antibodies; and a kit containing the antibodies.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

87.

METHOD FOR PRODUCING AROMATIC ASTATINE COMPOUND

      
Application Number 17760760
Status Pending
Filing Date 2021-02-18
First Publication Date 2022-11-10
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Matsunaga, Shigeki
  • Yoshino, Tatsuhiko
  • Matsuoka, Keitaro
  • Ogawa, Mikako

Abstract

This method for producing an aromatic astatine compound comprises reacting an aromatic iodonium ylide with astatine to produce an aromatic astatine compound.

IPC Classes  ?

  • C07J 1/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
  • C07D 209/48 - Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
  • C07C 69/712 - Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
  • C07D 215/16 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D 333/62 - Benzo [b] thiophenes; Hydrogenated benzo [b] thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
  • C07D 261/20 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

88.

Laminate, organic thin film solar cell, method for manufacturing laminate, and method for manufacturing organic thin film solar cell

      
Application Number 17760631
Grant Number 11683944
Status In Force
Filing Date 2020-09-28
First Publication Date 2022-10-20
Grant Date 2023-06-20
Owner
  • JFE Steel Corporation (Japan)
  • National University Corporation Hokkaido University (Japan)
Inventor
  • Suto, Mikito
  • Masuoka, Hiroyuki
  • Matsuzaki, Akira
  • Habazaki, Hiroki
  • Kobayashi, Hikaru

Abstract

A laminate which allows to obtain an organic thin-film solar cell having excellent output characteristics and transparency is provided. The laminate as above has a titanium oxide layer that is disposed on the member serving as a light-transmissive electrode layer and serves as an electron transport layer. The titanium oxide layer has a thickness of not less than 1.0 nm and not more than 200.0 nm. The titanium oxide layer contains indium oxide and metallic indium, InOx/Ti is not less than 0.50 and not more than 20.00 in atomic ratio, and InM/Ti is less than 0.100 in atomic ratio, where an elemental titanium content is represented by Ti, an indium oxide content is represented by InOx, and a metallic indium content is represented by InM.

IPC Classes  ?

  • H01L 31/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
  • H10K 30/82 - Transparent electrodes, e.g. indium tin oxide [ITO] electrodes
  • H10K 30/30 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains
  • H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
  • H10K 71/60 - Forming conductive regions or layers, e.g. electrodes
  • H10K 102/10 - Transparent electrodes, e.g. using graphene

89.

Heat-resistant alloy, heat-resistant alloy powder, heat-resistant alloy structural component, and manufacturing method of the same

      
Application Number 17764880
Grant Number 11846006
Status In Force
Filing Date 2020-10-02
First Publication Date 2022-10-13
Grant Date 2023-12-19
Owner
  • TOKYO METROPOLITAN PUBLIC UNIVERSITY CORPORATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kakehi, Koji
  • Hayashi, Shigenari
  • Kuo, Yen-Ling

Abstract

A heat-resistant alloy contains at least one element selected from a group consisting of Al, Ti, Ni, Cr, and Mo, O, and Y, and a ratio of a content of Y in terms of mass to a content of O in terms of mass is 0.5 or greater and 100 or less.

IPC Classes  ?

  • C22C 19/05 - Alloys based on nickel or cobalt based on nickel with chromium
  • C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
  • C22C 1/04 - Making non-ferrous alloys by powder metallurgy
  • B33Y 70/00 - Materials specially adapted for additive manufacturing
  • B22F 1/00 - Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties

90.

RARE EARTH COMPLEX, RARE EARTH COMPLEX SOLUTION, LUMINESCENT MOLDED ARTICLE, METHOD FOR PRODUCING LUMINESCENT PRODUCT, LUMINESCENT SHEET, AND VINYL GREENHOUSE FOR AGRICULTURE

      
Application Number 17606256
Status Pending
Filing Date 2020-04-23
First Publication Date 2022-10-06
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Kitagawa, Yuichi
  • Shima, Kaori
  • Wada, Satoshi
  • Hasegawa, Yasuchika
  • Fushimi, Koji

Abstract

Disclosed is a rare earth complex having a rare earth ion and a phosphine oxide ligand that is coordinated with the rare earth ion and is represented by the following formula (I): Disclosed is a rare earth complex having a rare earth ion and a phosphine oxide ligand that is coordinated with the rare earth ion and is represented by the following formula (I): wherein R1, R2, R3, R4, R5, and R6 each independently represent an alkyl group which may have a substituent.

IPC Classes  ?

  • C07F 9/53 - Organo-phosphine oxides; Organo-phosphine sulfides
  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
  • C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic System
  • A01G 9/14 - Greenhouses

91.

MECHANOREDOX REACTION USING PIEZOELECTRIC MATERIAL, AND PRODUCTION METHOD USING SAID REACTION

      
Application Number 17640135
Status Pending
Filing Date 2020-09-04
First Publication Date 2022-09-29
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Ito, Hajime
  • Kubota, Koji

Abstract

Disclosed are a method for producing a highly reactive intermediate, which comprises: preparing an electron-accepting active compound (1), preparing a piezoelectric material (3), and applying mechanical strain to the piezoelectric material (3) in the presence of the electron-accepting active compound (1) and the piezoelectric material (3), and subjecting the compound (1) to one-electron reduction to generate a corresponding highly reactive intermediate; a redox reaction method using the method for producing the same; and a method for producing a redox reaction product.

IPC Classes  ?

  • C07F 5/02 - Boron compounds
  • C07D 307/06 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
  • C07D 333/38 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D 333/10 - Thiophene

92.

MICROCAPSULE FOR LATENT HEAT STORAGE MATERIALS, METHOD FOR PRODUCING SAME, POWDER CONTAINING MICROCAPSULES FOR LATENT HEAT STORAGE MATERIALS, AND HEAT STORAGE DEVICE COMPRISING SAID POWDER

      
Application Number 17636349
Status Pending
Filing Date 2020-08-20
First Publication Date 2022-09-22
Owner National University Corporation Hokkaido University (Japan)
Inventor
  • Nomura, Takahiro
  • Kawaguchi, Takahiro
  • Sakai, Hiroki
  • Cho, Shunsuke
  • Kashiyama, Kohei
  • Sato, Kenji
  • Miya, Kazuyuki
  • Shibuya, Yoshitaka

Abstract

An object of the present invention is to provide a latent heat storage body which has a melting point of about 300 to 550° C. and is difficult to cause leakage of a phase changing material, and a product obtained by applying the body. An object of the present invention is to provide a latent heat storage body which has a melting point of about 300 to 550° C. and is difficult to cause leakage of a phase changing material, and a product obtained by applying the body. Provided is a microcapsule for latent heat storage materials including a metal core containing Zn and Al and a shell covering the metal core. An object of the present invention is to provide a latent heat storage body which has a melting point of about 300 to 550° C. and is difficult to cause leakage of a phase changing material, and a product obtained by applying the body. Provided is a microcapsule for latent heat storage materials including a metal core containing Zn and Al and a shell covering the metal core. The shell of the microcapsule includes an oxide film containing Zn and O, and an oxide film containing Al and O adjacent to an inner side of the oxide film. In the microcapsule, a mass ratio of ZnAl2O4 is 4% or less. The mass ratio is determined by analyzing the microcapsule by an XRD (X-ray diffractometer) device and subjecting results to quantitative analysis using a RIR (Reference Integrity Ratio) method.

IPC Classes  ?

  • C09K 5/06 - Materials undergoing a change of physical state when used the change of state being from liquid to solid or vice-versa
  • B22F 1/00 - Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
  • B22F 1/17 - Metallic particles coated with metal

93.

Planar Coil and Planar Transformer

      
Application Number 17632693
Status Pending
Filing Date 2020-06-09
First Publication Date 2022-09-08
Owner
  • Marelli Corporation (Japan)
  • National University Corporation Hokkaido University (Japan)
  • Utsunomiya University (Japan)
Inventor
  • Ogasawara, Satoshi
  • Orikawa, Koji
  • Funato, Hirohito
  • Haruna, Junnosuke
  • Okazaki, Fumihiro

Abstract

Variation in inductance is reduced with a secondary-side coil substrate on which a plurality of wiring layers are superimposedly disposed, and a plurality of coils provided in the secondary-side coil substrate. On the wiring layer, coil patterns corresponding to parts of one circumferences of the coils are formed. On the wiring layer, coil patterns corresponding to remaining parts of the one circumferences of the coils are formed. The coil patterns, and the coil patterns that are provided on the different wiring layers are connected to each other via conduction points in a superimposition direction of the wiring layers, and the one circumferences of the respective coils are formed.

IPC Classes  ?

  • H01F 27/28 - Coils; Windings; Conductive connections

94.

FUNDUS IMAGE PROCESSING DEVICE AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM STORING COMPUTER-READABLE INSTRUCTIONS

      
Application Number 17826884
Status Pending
Filing Date 2022-05-27
First Publication Date 2022-09-08
Owner
  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
  • NIDEK CO., LTD. (Japan)
Inventor
  • Saito, Michiyuki
  • Noda, Kousuke
  • Fukutsu, Kanae
  • Ishida, Susumu
  • Shiba, Ryosuke
  • Kumagai, Yoshiki

Abstract

A processor of a fundus image processing device acquires a fundus image 50 photographed by a fundus image photographing device. The processor acquires blood vessel images 60A and 60B that indicate at least one of an arteriole and a venule in the fundus image 50 by inputting the fundus image 50 into a mathematical model trained by a machine learning algorithm. The processor acquires a blood vessel area that is an area of at least one of the arteriole and the venule in the whole of the blood vessel images 60A and 60B.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • A61B 3/14 - Arrangements specially adapted for eye photography
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

95.

Polarization-transfer apparatus, and microfluidic device

      
Application Number 17632541
Grant Number 12055606
Status In Force
Filing Date 2020-08-06
First Publication Date 2022-09-01
Grant Date 2024-08-06
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Matsumoto, Shingo
  • Stewart, Neil
  • Uchio, Yoshiki

Abstract

15N nuclei, has a microfluidic device in which the precursor is guided in a magnetic shield such that the strength of the magnetic field acting on the precursor monotonically decreases from approximately 1 μT to zero magnetic field, and then the precursor is guided in the magnetic shield such that the strength of the magnetic field acting on the precursor monotonically increases from zero magnetic field to approximately 1 μT.

IPC Classes  ?

  • G01R 33/28 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance - Details of apparatus provided for in groups
  • G01R 33/30 - Sample handling arrangements, e.g. sample cells, spinning mechanisms
  • G01R 33/44 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
  • G01R 33/46 - NMR spectroscopy

96.

HEALTH DATA PROCESSING SYSTEM AND HEALTH DATA PROCESSING METHOD

      
Application Number 17575855
Status Pending
Filing Date 2022-01-14
First Publication Date 2022-08-18
Owner
  • National University Corporation Hokkaido University (Japan)
  • Hitachi, Ltd. (Japan)
Inventor
  • Nakamura, Takahiro
  • Watanabe, Jyunichiro
  • Takemoto, Takashi
  • Tamakoshi, Akiko
  • Kimura, Takashi

Abstract

A health data processing system in which an arithmetic unit can gain access to a database storing basic data of residents, health data of residents, and social capital index measurement data is provided. The health data processing system includes: an individual health condition analysis part which analyzes an individual health condition being each resident's health condition with use of the health data; a regional health condition analysis part which analyzes a regional health condition being a health condition of residents who belong to a region with use of the health data; an SCI derivation part which derives a regional SCI being a social capital index for every region with use of the social capital index measurement data; and an individually providing information generation part which generates information contributing to residents' health with use of the individual health condition, the regional health condition, and the regional SCI.

IPC Classes  ?

  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G06F 16/25 - Integrating or interfacing systems involving database management systems

97.

NUCLEAR REACTION DETECTION APPARATUS, METHOD, AND PROGRAM

      
Application Number 17624689
Status Pending
Filing Date 2020-07-03
First Publication Date 2022-08-18
Owner
  • Nippon Telegraph and Telephone Corporation (Japan)
  • National University Corporation Hokkaido University (Japan)
  • National University Corporation Tokai National Higher Education and Research System (Japan)
Inventor
  • Iwashita, Hidenori
  • Funatsu, Gentaro
  • Furusaka, Michihiro
  • Kamiyama, Takashi
  • Sato, Hirotaka
  • Kiyanagi, Yoshiaki

Abstract

A nuclear reaction detection device includes an FPGA (Field Programmable Gate Array) 100 which is arranged in an environment in which particle radiation is incident, and includes a user circuit 101 configured to output a value different from that in a normal state, if an SEU (Single Event Upset) occurs in a semiconductor element included in the FPGA, and an SEF detection unit 210 which detects that an abnormal operation (SEF) has occurred in the user circuit based on the output value from the user circuit 101 of the FPGA 100.

IPC Classes  ?

  • G01T 1/24 - Measuring radiation intensity with semiconductor detectors

98.

Nuclear reaction detection device, method and program with high detection position resolution

      
Application Number 17623752
Grant Number 11808901
Status In Force
Filing Date 2020-07-03
First Publication Date 2022-08-11
Grant Date 2023-11-07
Owner
  • Nippon Telegraph and Telephone Corporation (Japan)
  • National University Corporation Hokkaido University (Japan)
  • National University Corporation Tokai National Higher Education and Research System (Japan)
Inventor
  • Iwashita, Hidenori
  • Funatsu, Gentaro
  • Furusaka, Michihiro
  • Kamiyama, Takashi
  • Sato, Hirotaka
  • Kiyanagi, Yoshiaki

Abstract

A nuclear reaction detection device 100 includes a semiconductor memory 100 arranged in an environment in which radiation is incident, a position information storage unit 210 that stores spatial position information of a semiconductor element in the semiconductor memory 100, a bit position specifying unit 220 that detects that an SEU (Single Event Upset) has occurred in the semiconductor element included in the semiconductor memory 100, and specifies the semiconductor element in which the SEU has occurred, and a position calculating unit 230 that calculates a spatial position in which the SEU has occurred, based on the specified semiconductor element and the spatial position information.

IPC Classes  ?

  • G01T 1/16 - Measuring radiation intensity
  • G01T 1/24 - Measuring radiation intensity with semiconductor detectors
  • G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beam; Measurement of spatial distribution of radiation
  • G01T 3/08 - Measuring neutron radiation with semiconductor detectors

99.

LIPID NANOPARTICLE

      
Application Number 17595156
Status Pending
Filing Date 2020-05-27
First Publication Date 2022-07-07
Owner NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
  • Sato, Yusuke
  • Harashima, Hideyoshi
  • Tokeshi, Manabu
  • Maeki, Masatoshi

Abstract

The present invention addresses the problem of providing a lipid nanoparticle in which a nucleic acid, etc., required in genome editing is encapsulated and which can be produced by an alcohol dilution method using flow channels and contributes to high genome editing efficiency. The present invention pertains to a lipid nanoparticle which comprises a lipid component, a DNA nuclease, a guide RNA and a single-stranded oligonucleotide, wherein: the lipid component comprises a pH-sensitive cationic lipid, a neutral phospholipid and a polyalkylene glycol-modified lipid; the ratio of the pH-sensitive cationic lipid relative to the total lipids constituting the lipid nanoparticle is 30-50 mol %; the ratio of the neutral phospholipid relative to the total lipids constituting the lipid nanoparticle is 20-50 mol %; and the ratio of the polyalkylene glycol-modified lipid relative to the total lipids constituting the lipid nanoparticle is 1-4 mol %.

IPC Classes  ?

  • C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

100.

SINTERED BODY, METHOD FOR PRODUCING SAME, AND DIELECTRIC COMPOSITION

      
Application Number 17690528
Status Pending
Filing Date 2022-03-09
First Publication Date 2022-06-23
Owner
  • National University Corporation Hokkaido University (Japan)
  • Murata Manufacturing Co., Ltd. (Japan)
Inventor
  • Masubuchi, Yuji
  • Hosono, Akira
  • Kikkawa, Shinichi
  • Inoguchi, Masashi

Abstract

A sintered body containing polycrystalline grains of a metal oxynitride containing at least two metal elements, wherein Ba and at least one metal element of a crystal phase of the sintered body are contained in a triple point that is not a void between the polycrystalline grains. A method for producing the sintered body includes sintering a mixture of at least a metal oxynitride as a main component and a sintering aid containing cyanamide in an atmosphere containing nitrogen or a rare gas or in a reduced-pressure atmosphere of 10 Pa or less while applying a mechanical pressure with a retention time at a maximum heating temperature during the sintering set to 1 minute to 10 minutes.

IPC Classes  ?

  • C04B 35/58 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides
  • C04B 35/645 - Pressure sintering
  • C04B 35/63 - Preparing or treating the powders individually or as batches using additives specially adapted for forming the products
  • B01J 27/24 - Nitrogen compounds
  • B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
  • B01J 37/08 - Heat treatment
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • H01G 4/12 - Ceramic dielectrics
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