NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Takahashi, Yukihiro
Moteki, Youhei
Naruse, Nobuyasu
Abstract
The spectroscopic measuring instrument includes: a spectrometer to make measurement of a reflection spectrum of an object relative to a light source and output measurement information representing a result of the measurement; a shadow projector including obstacie(s) to allow light from the light source to cast shadow(s) on an object surface; an imaging device to output image information representing an image of an imaging area including the object surface; a storage interface removably connectable to a computer readable medium; and a processing device. The processing device is connected to the spectrometer, the imaging device and the storage interface, and performs a measurement process of storing the measurement information from the spectrometer and the image information from the imaging device in the computer readable medium connected to the storage interface.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Takahashi, Yukihiro
Ono, Tatsuharu
Naruse, Nobuyasu
Ishida, Yurino
Abstract
An information processing system includes a storage, an interface device, and a computing circuit. The storage stores a database, in which spectrum data concerning light from a light source and a measurement condition data at a time of measurement of the light are associated with a plant status data concerning growth of a plant and/or a harvest data concerning a harvest of the plant. The interface device receives an input of a user measurement condition which is to be applied at a time of measurement of the plant by a user and which includes data concerning angles at the time of measurement and data concerning a plant status and/or a harvest to be predicted. The computing circuit determines at least two wavelengths contained in the light from the light source to be measured under the user measurement condition by referring to the database based on the user measurement condition.
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Miyazaki, Yuta
Arai, Takayuki
Ito, Masayoshi
Negishi, Hashiru
Harashima, Hideyoshi
Sato, Yusuke
Abstract
A method for purifying a composition that comprises a step for dissolving the composition containing a compound represented by formula(1) [in formula (1): R1 represents -N(R2)-R2 (wherein R2 represents a C1-C4 alkyl group); R3 and R4 represent a C3-C8 alkanediyl group; R5 represents a hydroxyl group; R6 represents -R7-OH (wherein R7 represents a C4-C12 alkanediyl group) or a hydrogen atom; and n is an integer of 0 or 1] in an aqueous layer and performing liquid-liquid extraction, wherein an oil layer used in the liquid-liquid extraction contains one or more liquids selected from the group consisting of a ketone liquid, an ester liquid and an ether liquid each having a solubility parameter (SP value) of 14.8-20.5 (MPa1/2).
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
C07C 219/08 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
C07C 229/12 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Tachibana, Yuki
Uehara, Shota
Unoh, Yuto
Nakahara, Kenji
Taoda, Yoshiyuki
Kasamatsu, Koji
Yamatsu, Yukiko
Ando, Shigeru
Fukao, Keita
Nobori, Haruaki
Kuroda, Takayuki
Toba, Shinsuke
Uemura, Kentaro
Maruyama, Yuki
Sasaki, Michihito
Sawa, Hirofumi
Abstract
The present invention provides a pharmaceutical composition containing a compound that exhibits a coronavirus growth inhibitory activity. A pharmaceutical composition containing a compound represented by the formula (wherein: Y is N; R1 represents an optionally substituted aromatic heterocyclic group; R2 represents an optionally substituted 6-membered aromatic carbon ring group; R3 represents an optionally substituted aromatic heterocyclic group; -X- is -NH-; m is 0 or 1; R5a represents a hydrogen atom; R5b represents a hydrogen atom; n is 1; R4a represents a hydrogen atom; and R4b represents a hydrogen atom) or a pharmaceutically acceptable salt thereof.
A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 31/5355 - Non-condensed oxazines containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
PUREC CO., LTD. (Japan)
MOCHIDA PHARMACEUTICAL CO., LTD. (Japan)
Inventor
Sudo, Hideki
Ukeba, Daisuke
Yamada, Katsuhisa
Ura, Katsuro
Suzuki, Hisataka
Iyoku, Yumi
Suyama, Takashi
Abstract
Provided is a composition for promoting the regeneration of nucleus pulposus of intervertebral disc, said composition comprising a monovalent metal salt of a low endotoxin alginic acid and mesenchymal stem cells. In particular, the composition according to the present invention promotes the regeneration of nucleus pulposus of intervertebral disc via the activation of nucleus pulposus cells by human bone marrow-derived high-purity mesenchymal stem cells and/or the differentiation of human bone marrow-derived high-purity mesenchymal stem cells into nucleus pulposus cells.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Maenaka, Katsumi
Matsuda, Akira
Sawa, Hirofumi
Orba, Yasuko
Sasaki, Michihito
Uemura, Kentaro
Abstract
The present invention provides an anti-viral agent and the like including a compound represented by general formula (1) or (2) (where R1 is -(CH2)n1-Z1-R11 or -CH-(-Z1-R11)2 (n1 is 0 or 1; Z1 is a single bond, -O-, -NH-, -S-, -SO-, -SO2-, -CO-, -CO-O-, or -CH=N-O-; R11 is a hydrogen atom, a C1-6 alkyl group, -NR12R13, -N3, -NO2, -CN, -CH2-CO-O-R14, or a nitrogen atom-containing 5-membered or 6-membered heterocyclic group; R12 and R13 are each independently a hydrogen atom or a C1-6 alkyl group; and R14 is a hydrogen atom or a C1-6 alkyl group; with the proviso that, in the heterocyclic group, a nitrogen atom in the ring group is linked to Z1) or a derivative thereof, a salt of these compounds, or a solvate of these.
A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Tachibana, Yuki
Uehara, Shota
Unoh, Yuto
Nakahara, Kenji
Taoda, Yoshiyuki
Yamatsu, Yukiko
Ando, Shigeru
Sasaki, Michihito
Abstract
The present invention provides a compound exhibiting a coronavirus 3CL protease inhibitory effect and pharmaceutically acceptable salts thereof, and a pharmaceutical composition containing the same. Further provided are crystals that are useful as a drug substance, and a pharmaceutical composition containing the same. The compound represented by formula (1) or pharmaceutically acceptable salts thereof.
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
NITTO DENKO CORPORATION (Japan)
Inventor
Sato, Yusuke
Harashima, Hideyoshi
Hashiba, Kazuki
Taguchi, Masamitsu
Sakamoto, Sachiko
Shishido, Takuya
Otsu, Ayaka
Maeda, Yoshiki
Abstract
The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a straight-chain or branched-chain C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B) (d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I): (R1)(R2)C(OH)-(CH2)a-(O-CO)b-X. (A): (R11)(R12)-CH-(CO-O)c-(CH2)v-. (B): -(CH2)d-N(R3)(R4).
A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/44 - Oils, fats or waxes according to two or more groups of ; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
9.
METHOD FOR SCREENING ANTICANCER AGENT AND COMBINATION DRUG OF KINASE INHIBITORS FOR TREATMENT OF PANCREATIC CANCER
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Sonoshita, Masahiro
Sekiya, Sho
Hirano, Satoshi
Abstract
The present invention relates to a method for screening an anticancer agent by causing drosophila having the characteristics of a) expression of mutant Ras85D, b) deletion or suppressed expression of a p53 gene, c) overexpression of a cyclin E gene, and d) deletion or suppressed expression of a Med gene to ingest a test substance and comparing the survival rate thereof with the survival rate of drosophila that did not ingest the test substance. The present invention also relates to a combination drug of at least two kinase inhibitors for treatment of pancreatic cancer and to kinase inhibitors for use in said combination drug.
A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C12N 9/99 - Enzyme inactivation by chemical treatment
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Higashino, Fumihiro
Abstract
[Problem] The purpose of the present invention is to provide a modified adenovirus having a cytocidal activity on a target cell and high safety. [Solution] The present invention pertains to: a modified adenovirus which comprises an E1A gene, an enhancer sequence having a function of enhancing the expression of the E1A gene, and an AU-rich element introduced into the 3'-untranslated region of a viral gene, which is essentially required for the self-propagation thereof, or a position adjacent to the 3'-untranslated region, or a modified adenovirus which comprises an E1A gene and an enhancer sequence having a function of enhancing the expression of the E1A gene and cannot express normal E4orf6 protein, wherein the distance between the 5'-terminus of the E1A gene and the terminus of the enhancer sequence is 1500-4500 bp; and a medicine comprising the same.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
TOSHIBA MITSUBISHI-ELECTRIC INDUSTRIAL SYSTEMS CORPORATION (Japan)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Yamamoto, Yushin
Ogasawara, Satoshi
Ohara, Shunsuke
Abstract
This power conversion device is provided with: a voltage detection means for detecting a common-mode voltage generated during a switching operation of a power semiconductor element; a voltage superposition means for superposing the common-mode voltage detected by the voltage detection means on an output of the power conversion device to cancel the common-mode voltage in a frequency equal to or higher than a switching frequency generated during the switching operation of the power semiconductor element; and a residual voltage detection means for detecting the common-mode voltage of the power conversion device superposed by the voltage superposition means. The voltage superposition means includes a feedback means for adding the common-mode voltage detected by the residual voltage detection means and superposing the added result on the output of the power conversion device. The voltage detection means comprises a first choke coil and a first capacitor.
H02M 7/48 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Suzuki, Yasuhiko
Nakagawa, Miki
Kameda, Yayoi
Konnai, Satoru
Okagawa, Tomohiro
Maekawa, Naoya
Goto, Shinya
Sajiki, Yamato
Ohashi, Kazuhiko
Murata, Shiro
Kitahara, Yuzuru
Yamamoto, Keiichi
Abstract
Provided is an expression vector for mammalian cells, which imparts to mammalian host cells a high-level production capability for a protein derived from a foreign gene. The amount of a desired protein that is produced in a transformant is increased by a plasmid DNA being incorporated into a transfer hotspot on the chromosome of a dihydrofolate reducing enzyme gene-deficient host cell, the foregoing being achieved by introducing a ubiquitously-acting chromatin opening element (UCOE) to an expression vector configured for selection of a strain that grows in a culture that does not contain hypoxanthine thymidine (hereinafter referred to as "HT").
C12N 1/15 - Fungi ; Culture media therefor modified by introduction of foreign genetic material
C12N 1/19 - Yeasts; Culture media therefor modified by introduction of foreign genetic material
C12N 1/21 - Bacteria; Culture media therefor modified by introduction of foreign genetic material
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
TOSOH CORPORATION (Japan)
Inventor
Fukuoka, Atsushi
Kobayashi, Hirokazu
Someya, Sae
Abstract
[Problem] To provide a partial oxidation catalyst that causes a light hydrocarbon partial oxidation reaction to proceed readily with high activity and high selectivity and a high-yield carbon monoxide production method using the same. [Solution] The invention is a light hydrocarbon partial oxidation catalyst containing a zeolite supporting cobalt and rhodium.
C01B 3/40 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts characterised by the catalyst
14.
COMBINATION USE OF INHIBITOR TARGETING PD-1/PD-L1 AND COX-2 INHIBITOR
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Konnai, Satoru
Ohashi, Kazuhiko
Murata, Shiro
Okagawa, Tomohiro
Maekawa, Naoya
Nishimori, Asami
Goto, Shinya
Suzuki, Yasuhiko
Nakajima, Chie
Sajiki, Yamato
Abstract
Provided are: a new therapeutic strategy by using an inhibitor that targets PD-1/PD-L1; a pharmaceutical composition which contains a COX-2 inhibitor and is administered at any period of time prior to, subsequent to, or at the same time of the administering of the inhibitor targeting PD-1/PD-L1; and an immunostimulating effect enhancer which is for the inhibitor targeting PD-1/PD-L1 and contains a COX-2 inhibitor.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A61K 31/63 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
LIFE SCIENCE INSTITUTE, INC. (Japan)
Inventor
Shimizu, Hiroshi
Fujita, Yasuyuki
Masutomi, Naoya
Abstract
Provided is a cell preparation for treating epidermolysis bullosa, containing SSEA-3 positive pluripotent stem cells (muse cells) derived from a mesenchymal tissue of a live body or cultured mesenchymal cells. The epidermolysis bullosa is preferably epidermolysis bullosa simplex, junctional epidermolysis bullosa, or dystrophic epidermolysis bullosa.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Harashima, Hideyoshi
Sato, Yusuke
Abstract
A lipid membrane structure contains, as a lipid component, a lipid compound represented by formula (I): (R1)(R2)C(OH)-(CH2)a-(O-CO)b-X [wherein a represents an integer of 3 to 5; b represents an integer of 0 or 1; R1 and R2 independently represent a linear hydrocarbon group that may have -CO-O-; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by formula (B) (wherein d represents an integer of 0 to 3; and R3 and R4 independently represent a C1-4 alkyl group or a C2-4 alkenyl group, wherein R3 and R4 may be bonded together to form a 5- to 7-membered non-aromatic hetero ring (wherein one or two C1-4 alkyl groups or C2-4 alkenyl groups may be present as substituents on the ring))].
C07C 69/30 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with trihydroxylic compounds
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
C07D 211/32 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
C07D 295/03 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
17.
FLOW CHANNEL STRUCTURE AND LIPID PARTICLE OR MICELLE FORMATION METHOD USING SAME
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Tokeshi, Manabu
Maeki, Masatoshi
Sato, Yusuke
Harashima, Hideyoshi
Abstract
Provided are: a flow channel structure with which lipid particles or micelles, which are useful as nano-sized carriers, for example, in drug delivery systems, are produced with good control of particle size; and a method for forming lipid particles or micelles using the same. Said flow channel structure has a two-dimensional structure such as one in which multiple structural elements (baffles) of a specified width are alternately disposed from the two side faces in a micro-sized flow channel through which feedstock solutions are flowed.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Konnai, Satoru
Ohashi, Kazuhiko
Murata, Shiro
Okagawa, Tomohiro
Nishimori, Asami
Maekawa, Naoya
Takagi, Satoshi
Kagawa, Yumiko
Suzuki, Yasuhiko
Nakajima, Chie
Abstract
Provided is an anti-PD-L1 antibody capable of staining tumor cells such as melanoma. The anti-PD-L1 antibody comprises: (a) an L-chain which includes CDR1 having the amino acid sequence KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence SGS and CDR3 having the amino acid sequence QQHNEYPLT (SEQ ID NO: 2); and (b) an H-chain which includes CDR1 having the amino acid sequence GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence ARGITMMVVISHWKFDF (SEQ ID NO: 5). A composition for detecting PD-L1, said composition comprising the anti-PD-L1 antibody as an active ingredient. Also provided is a method for producing the anti-PD-L1 antibody.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Takahashi, Yukihiro
Naruse, Nobuyasu
Abstract
An object state detection/transmission system provided with: a spectroscopy terminal device in which a spectroscope for measuring a reflection spectrum on the basis of reflected light reflected by a target object and an electronic instrument for receiving the measured reflection spectrum are integrally provided; and a server device connected to the spectroscopy terminal device via a communication line; wherein the electronic instrument is provided with an imaging means for capturing an image of the target object and obtaining a captured image, a GPS means for measuring the position of the target object, a sensor means for measuring the azimuth and angle of the target object, a clocking means for clocking the imaging and a predetermined time, and a communication means for transmitting the captured image, the position of the target object, the azimuth and angle of the target object, and the imaging time and the predetermined time together with the received reflection spectrum to the server device.
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Konnai, Satoru
Ohashi, Kazuhiko
Murata, Shiro
Okagawa, Tomohiro
Nishimori, Asami
Maekawa, Naoya
Suzuki, Yasuhiko
Nakajima, Chie
Abstract
Provided is an anti-PD-L1 antibody that can be frequently administered to animals other than rats. The anti-PD-L1 antibody contains (a) an L-chain and (b) an H-chain. Said L-chain has: an L-chain-variable region including CDR1 that has the amino acid sequence QSLLYSENQKDY (SEQ ID NO: 37), CDR2 that has the amino acid sequence WAT, and CDR3 that has the amino acid sequence GQYLVYPFT (SEQ ID NO: 38); and an L-chain-constant region of an antibody of an animal other than a rat. Said H-chain has: an H-chain-variable region including CDR1 that has the amino acid sequence GYTFTSNF (SEQ ID NO: 39), CDR2 that has the amino acid sequence IYPEYGNT (SEQ ID NO: 40), and CDR3 that has the amino acid sequence ASEEAVISLVY (SEQ ID NO: 41); and an H-chain-constant region of an antibody of an animal other than a rat. A pharmaceutical composition comprising the anti-PD-L1 antibody as an active ingredient. A method of producing the anti-PD-L1 antibody is also provided.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Konnai, Satoru
Ohashi, Kazuhiko
Murata, Shiro
Okagawa, Tomohiro
Nishimori, Asami
Maekawa, Naoya
Suzuki, Yasuhiko
Nakajima, Chie
Abstract
Provided is an anti-PD-1 antibody that can be administered frequently even to animals other than rats. An anti-PD-1 antibody including: (a) an L chain that has an L chain variable region including CDR1 having the amino acid sequence of QSLEYSDGYTY (SEQ ID NO: 16), CDR2 having the amino acid sequence of GVS, and CDR3 having the amino acid sequence of FQATHDPDT (SEQ ID NO: 17), and also has an L chain constant region of an animal antibody other than rat; and (b) an H chain that has an H chain variable region including CDR1 having the amino acid sequence of GFSLTSYY (SEQ ID NO: 18), CDR2 having the amino acid sequence of IRSGGST (SEQ ID NO: 19), and CDR3 having the amino acid sequence of ARTSSGYEGGFDY (SEQ ID NO: 20), and also has an H chain constant region of an animal antibody other than rat. A pharmaceutical composition containing the anti-PD-1 antibody as an active ingredient. Also provided is a method for producing the anti-PD-1 antibody.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Konnai, Satoru
Ohashi, Kazuhiko
Murata, Shiro
Okagawa, Tomohiro
Nishimori, Asami
Maekawa, Naoya
Suzuki, Yasuhiko
Nakajima, Chie
Abstract
Provided is an anti-LAG-3 antibody that can be frequently administered to a non-rat animal. The anti-LAG-3 antibody comprises: (a) an L chain comprising an L-chain variable region that includes CDR1 having a QSLLDSDGNTY (SEQ ID NO. 16) amino acid sequence, CDR2 having an SVS amino acid sequence, and CDR3 having an MQATHVPFT (SEQ ID NO. 17) amino acid sequence, and an L-chain constant region of a non-rat mammalian antibody; and (b) an H chain comprising an H-chain variable region that includes CDR1 having a GFDFDTYP (SEQ ID NO. 18) amino acid sequence, CDR2 having an ITIKTHNYAT (SEQ ID NO. 19) amino acid sequence, and CDR3 having an NREDFDY (SEQ ID NO. 20) amino acid sequence, and an H-chain constant region of a non-rat mammalian antibody. Also provided is a pharmaceutical composition containing the anti-LAG-3 antibody as an active ingredient. Also provided is a method of producing the anti-LAG-3 antibody.
A61P 35/02 - Antineoplastic agents specific for leukemia
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
SPECTRAL CAMERA CONTROL DEVICE, SPECTRAL CAMERA CONTROL PROGRAM, SPECTRAL CAMERA CONTROL SYSTEM, AIRCRAFT EQUIPPED WITH SAID SYSTEM, AND SPECTRAL IMAGE CAPTURING METHOD
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Takahashi, Yukihiro
Kurihara, Junichi
Ishida, Tetsuro
Abstract
[Problem] To provide a spectral camera control device, a spectral camera control program, a spectral camera control system, an aircraft equipped with said system, and a spectral image capturing method, with which it is possible for each of a spatial resolution and an exposure time for spectral image capture to be set arbitrarily, and with which spatial distortion and displacement of the spectral image can be suppressed. [Solution] This spectral camera control device is installed together with a spectral camera 3 provided with a liquid crystal tunable filter 33 in an aircraft 1 capable of stationary flight, and causes the spectral camera 3 to capture an image in a snapshot mode each time the transmission wavelength of the liquid crystal tunable filter 33 is switched while the aircraft 1 is in stationary flight.
G02F 1/13 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
24.
COMPOSITION COMPRISING A SALT OF ALGINIC ACID FOR TREATING INTERVERTEBRAL DISC
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
MOCHIDA PHARMACEUTICAL CO., LTD. (Japan)
Inventor
Sudo, Hideki
Tsujimoto, Takeru
Iwasaki, Norimasa
Shimizu, Satoshi
Isaji, Mitsuko
Abstract
The present invention provides a composition for replenishing the nucleus pulposus of an intervertebral disc, the composition containing a monovalent metal salt of a low endotoxin alginic acid. The composition is applied to a nucleus pulposus site of a subject, is used to harden a part after application, and has fluidity when applied to the nucleus pulposus site. Accordingly, a composition for replenishing nucleus pulposus is provided, the composition being capable of promoting the regeneration of the nucleus pulposus of an intervertebral disc.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Takada, Ayato
Yoshida, Reiko
Furuyama, Wakako
Miyamoto, Hiroko
Maruyama, Junki
Iida, Shigeru
Ogawa, Shinya
Abstract
A neutral monoclonal antibody useful for effective antibody therapy against Ebola virus is needed. The present invention provides a monoclonal antibody or antigen-binding fragment thereof that is capable of recognizing the GP internal membrane fusion loop of Ebola virus and neutralizing the biological activity of Ebola virus.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Nakai, Yuta
Tange, Kota
Akita, Hidetaka
Harashima, Hideyoshi
Togashi, Ryohei
Miura, Naoya
Maeta, Mio
Abstract
The purpose of the present invention is to provide a cationic lipid that can be used as a nucleic acid delivery carrier, a lipid membrane structure in which the cationic lipid is used, a nucleic-acid-introducing agent in which the cationic lipid is used, and a method for achieving nucleic acid introduction using the nucleic-acid-introducing agent containing the cationic lipid. The lipid membrane structure containing the cationic lipid represented by formula (1) (in the formula, each of the symbols is as defined in the specification) has exceptional stability in the blood and tumor accumulation properties. The nucleic-acid-introducing agent in which this cationic lipid is used makes it possible to achieve high nucleic acid delivery efficiency of a nucleic acid to be delivered into the cytoplasm.
C07D 295/088 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 43/00 - Drugs for specific purposes, not provided for in groups
C07D 311/00 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Sasaki, Shota
Ota, Masaki
Kubo, Kazuhiro
Harashima, Hideyoshi
Akita, Hidetaka
Hatakeyama, Hiroto
Noguchi, Yuki
Tange, Kota
Nakai, Yuta
Shimizu, Nayuta
Abstract
An object of the present invention is to provide a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. A cationic lipid represented by the formula (1): (see formula 1) wherein each symbol is as defined in the present DESCRIPTION.
C07C 229/12 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 43/00 - Drugs for specific purposes, not provided for in groups
28.
OBJECT DETECTION APPARATUS, OBJECT DETECTION METHOD, AND OBJECT DETECTION SYSTEM
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Kumeno, Hiroyuki
Okamoto, Yuji
Murai, Yuichi
Oishi, Yoshihiko
Tasaka, Yuji
Abstract
The problem addressed by the present invention is to provide an object detection device that can infer the size of a moving object easily from an image. The object detection device (5) of an object detection system (1) has an object detection/determination unit (7) that analyzes the cycle of motion of an object from an image, and from the cycle of motion of the object, infers the size of the object.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Wakao, Hiroshi
Fujita, Hiroyoshi
Koshimizu, Uichi
Yoshikiyo, Kazunori
Abstract
The object of the present invention is to provide a method for preparing induced pluripotent stem cells from MAIT cells, and providing induced pluripotent stem cells derived from MAIT cells. Another object of the present invention is to provide a method for preparing MAIT-like cells from induced pluripotent stem cells, and providing MAIT-like cells. Differentiation of the induced pluripotent stem cells having a MAIT cell-specific TCR gene can be induced to establish MAIT-like cells.
C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (Japan)
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
Inventor
Fujii, Chihiro
Oshima, Yasuhiro
Kishimoto, Takeaki
Kobayashi, Rieko
Taira, Akiko
Ozaki, Jun-Ichi
Kumagai, Haruo
Abstract
Provided is a hydrogen storing carbon material with improved hydrogen storage capacity. The hydrogen storing carbon material has a total pore volume of at least 0.5 cm3/g, and the ratio of the total mesoporous volume to the total microporous volume per unit weight is at least 5. Moreover, the aforementioned hydrogen storing carbon material may have a nitrogen content of 0.5 wt% to less than 20 wt%. Furthermore, in an electrochemical measurement by chronopotentiometry in which the aforementioned hydrogen storing carbon material is used in a working electrode in the three-electrode method, when a cathode current is maintained at 1000 mA/g with respect to the aforementioned hydrogen storing carbon material, the stable potential may be -1.28 V or above.
B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
C01B 3/00 - Hydrogen; Gaseous mixtures containing hydrogen; Separation of hydrogen from mixtures containing it; Purification of hydrogen
31.
EXPRESSION VECTOR FOR PRODUCING PROTEIN DERIVED FROM FOREIGN GENE IN LARGE QUANTITY USING ANIMAL CELLS, AND USE THEREOF
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Tahara, Hiroshi
Suzuki, Yusuke
Yamamoto, Keiichi
Kitahara, Yuzuru
Suzuki, Yasuhiko
Abstract
The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a gene cassette which has a cloning site for incorporation of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Japan)
Inventor
Suzuki, Yusuke
Tahara, Hiroshi
Yamamoto, Keiichi
Kitahara, Yuzuru
Suzuki, Yasuhiko
Abstract
As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.