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C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials 93
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons 92
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof 92
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System 74
H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED) 72
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1.

SYSTEMS AND METHODS FOR NON-DESTRUCTIVE ISOLATION, CONCENTRATION, AND DETECTION FOR UNBIASED CHARACTERIZATION OF NANO- AND BIOPARTICLES

      
Application Number 18563438
Status Pending
Filing Date 2022-05-25
First Publication Date 2024-06-06
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • UNIVERSITY OF UTAH RESEARCH FOUNDATION (USA)
Inventor
  • Hayes, Mark
  • Skliar, Mikhail
  • Porter, Marc
  • Copp, Brennan
  • Hayes, Samuel
  • Ramirez, Alexis

Abstract

The present disclosure provides systems and methods for separating one or more analytes within a fluid mixture, and characterizing and/or detecting properties associated with the one or more analytes. In some embodiments, the systems provided herein contain a dielectrophoresis device, such as a gradient insulator-based dielectrophoresis device (g-iDEP). The present disclosure provides systems and methods for separating and characterizing analytes using particle or nanoparticle tracking analysis (NTA). NTA offers various advantages because, particle size and concentration can be calculated in real time, allowing label-free and simultaneous characterization and separation of samples with mixed and unknown analytes.

IPC Classes  ?

  • B03C 5/00 - Separating dispersed particles from liquids by electrostatic effect
  • B03C 5/02 - Separators

2.

SYSTEMS AND METHODS FOR FRACTURE-PATTERN PREDICTION WITH RANDOM MICROSTRUCTURE USING PHYSICS-INFORMED DEEP NEURAL NETWORKS

      
Application Number 18223378
Status Pending
Filing Date 2023-07-18
First Publication Date 2024-06-06
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor Liu, Yongming

Abstract

Material fracture is a process involving both linear elastic stage and nonlinear crack propagation stage. A system includes a physics-informed deep learning model integrated with a discrete simulation model (lattice particle method-LPM) to predict material fracture patterns for arbitrary material microstructures under different loadings. The key idea is to leverage physics-knowledge and data-driven approach for accurate and efficient nonlinear mapping. Physics-knowledge includes constraints, microstructure images, and displacement field from pure linear elastic analysis in a linear stage. A Fully Convolutional Network predicts the final fracture patterns in a non-linear stage. The system exhibits high computational efficiency for the nonlinear stage of material response prediction.

IPC Classes  ?

  • G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

3.

SYSTEMS AND METHODS FOR DIGITAL SPEECH-BASED EVALUATION OF COGNITIVE FUNCTION

      
Application Number 18553335
Status Pending
Filing Date 2022-03-31
First Publication Date 2024-06-06
Owner
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
  • Aural Analytics, Inc. (USA)
Inventor
  • Stegmann, Gabriela
  • Liss, Julie
  • Berisha, Visar
  • Hahn, Shira

Abstract

Disclosed herein are systems and methods for evaluating or analyzing cognitive function or impairment using speech analysis. In some implementations the evaluation of cognitive function comprises a predicted future cognitive function or change in cognitive function. In some implementations the cognitive function is evaluated using a panel or speech features such as a metric of semantic relevance, MATTR, and other relevant features. In another aspect, a machine learning predictive model for evaluating cognitive function based on speech, comprising: receiving input signal comprising speech audio for a plurality of subjects, to detect one or more metrics of speech identifying classifications corresponding to cognitive function and training a model using machine learning based on a training data set comprising the one or more metrics of speech and the classifications identified in the speech audio, thereby generating a machine learning predictive model configured to generate an evaluation of cognitive function based on speech.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G10L 15/18 - Speech classification or search using natural language modelling
  • G10L 25/66 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for extracting parameters related to health condition

4.

SYSTEMS AND METHODS FOR AN AT-RISK SYSTEM IDENTIFICATION VIA ANALYSIS OF ONLINE HACKER COMMUNITY DISCUSSIONS

      
Application Number 18343138
Status Pending
Filing Date 2023-06-28
First Publication Date 2024-05-30
Owner
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
  • Cyber Reconnaissance, Inc. (USA)
Inventor
  • Nunes, Eric
  • Shakarian, Jana
  • Shakarian, Paulo
  • Almukaynizi, Mohammed
  • Singh, Harshdeep
  • Simari, Gerardo
  • Sharma, Anant

Abstract

Various embodiments of systems and methods for an at-risk system identification via analysis of discussions from various online hacker communities are disclosed herein.

IPC Classes  ?

  • G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
  • G06F 16/951 - Indexing; Web crawling techniques
  • G06F 16/9536 - Search customisation based on social or collaborative filtering
  • G06N 20/00 - Machine learning

5.

SYSTEMS AND METHODS FOR EXPEDIENT COMPUTATION OF SUBSTRATE DEFORMATIONS IN THERMO-COMPRESSION BONDING

      
Application Number 18525699
Status Pending
Filing Date 2023-11-30
First Publication Date 2024-05-30
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Mignolet, Marc
  • Wang, Xiaoquan

Abstract

A system can apply a Global Reduced Order Modeling (ROM), a Zonal ROM, or a Layer-By-Layer analysis method to accelerate computations of a static displacement field of a substrate during modeling of thermo-compression bonding. The system fully takes into account a glass transition of dielectric substrates as well as nonhomogeneity of the various layers.

IPC Classes  ?

  • G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
  • G16C 20/70 - Machine learning, data mining or chemometrics
  • G16C 20/80 - Data visualisation

6.

NATURAL COUNTER-SELECTION STRATEGY FOR PLASMID-FREE GENOME ENGINEERING IN POLYPLOID ORGANISMS

      
Application Number 18389738
Status Pending
Filing Date 2023-12-19
First Publication Date 2024-05-16
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Nielsen, David
  • Jones, Christopher

Abstract

Compositions and methods for genetically modifying at least one nucleic acid sequence of interest in a polyploid organism.

IPC Classes  ?

  • C12N 15/90 - Stable introduction of foreign DNA into chromosome
  • C12N 15/86 - Viral vectors
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
  • C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

7.

SURFACE ATTRITION TREATMENT, COMPOSITIONS, AND METHODS OF USE THEREOF

      
Application Number 18388317
Status Pending
Filing Date 2023-11-09
First Publication Date 2024-05-16
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • DEVCOM Army Research Laboratory (USA)
Inventor
  • Beura, Vikrant
  • Solanki, Kiran
  • Darling, Kris

Abstract

The present invention relates to surface attrition treatment, compositions, and methods of use thereof.

IPC Classes  ?

  • C22F 1/057 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of aluminium or alloys based thereon of alloys with copper as the next major constituent
  • B24C 1/10 - Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods for compacting surfaces, e.g. shot-peening
  • C22C 21/00 - Alloys based on aluminium
  • C22C 21/02 - Alloys based on aluminium with silicon as the next major constituent
  • C22C 21/14 - Alloys based on aluminium with copper as the next major constituent with silicon
  • C22C 21/16 - Alloys based on aluminium with copper as the next major constituent with magnesium
  • C22C 30/02 - Alloys containing less than 50% by weight of each constituent containing copper
  • C22F 1/04 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of aluminium or alloys based thereon
  • C22F 1/043 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of aluminium or alloys based thereon of alloys with silicon as the next major constituent
  • C22F 1/16 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon

8.

NANOCAGED ENZYMES WITH ENHANCED CATALYTIC ACTIVITY AND INCREASED STABILITY

      
Application Number 18481955
Status Pending
Filing Date 2023-10-05
First Publication Date 2024-05-16
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Fu, Jinglin
  • Zhao, Zhao
  • Woodbury, Neal
  • Yan, Hao

Abstract

The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.

IPC Classes  ?

  • C12N 11/04 - Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
  • C12N 11/06 - Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
  • C12N 11/10 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof

9.

WASTEWATER-BASED EPIDEMIOLOGY METHODS FOR ASSESSING POPULATION HEALTH

      
Application Number 18496832
Status Pending
Filing Date 2023-10-27
First Publication Date 2024-05-16
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Halden, Rolf
  • Adhikari, Sangeet
  • Driver, Erin
  • Kumar, Rahul
  • Zevitz, Jacob
  • Bowes, Devin A.
  • Amin, Vivek

Abstract

Disclosed herein are methods of assessing a population's health using wastewater samples. For example, the methods assess exposure to pathogens, plasticizers, volatile organic compounds, surfactant, hazardous chemical, nicotine, and/or other environmental toxins. In some aspects, the methods determine the concentration of disease biomarkers, chemical biomarker, certain human hormones, certain genes, pharmaceuticals, illicit drugs, personal care product, pathogens, and/or endogenous mental health markers. In some aspects, the methods assess population health at a neighborhood level. The methods may also be used to assess population health at a larger regional level, for example at a state level or a national level.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/573 - Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
  • G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

10.

OPTIMAL PRODUCTION OF SARS-COV-2 VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN MAMMALIAN CELLS

      
Application Number 18552762
Status Pending
Filing Date 2022-03-30
First Publication Date 2024-05-16
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor Hogue, Brenda

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus-like particles (VLP) are provided herein as well as methods of making and using the same. The methods of making the VLPs include transfecting a mammalian cell with expression vectors allowing for expression of at least the SARS-CoV-2 M, E and S proteins to make the VLPs. The VLPs can be administered to a subject to induce an immune response against SARS-CoV-2.

IPC Classes  ?

  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/12 - Viral antigens
  • A61P 31/14 - Antivirals for RNA viruses
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

11.

Hyper Efficient Separations Device

      
Application Number 18479220
Status Pending
Filing Date 2023-10-02
First Publication Date 2024-05-09
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Hayes, Mark
  • Crowther, Claire
  • Jones, Paul

Abstract

The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.

IPC Classes  ?

  • B03C 5/02 - Separators
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B03C 5/00 - Separating dispersed particles from liquids by electrostatic effect
  • G01N 15/10 - Investigating individual particles
  • G01N 15/14 - Electro-optical investigation
  • G01N 27/447 - Systems using electrophoresis

12.

HIGH DENSITY AND MULTIPLEXED NANOPORE DEVICES WITH TRANSVERSE TUNNELING JUNCTION FOR BIOMOLECULE DETECTION AND SEQUENCING

      
Application Number 18550881
Status Pending
Filing Date 2022-03-15
First Publication Date 2024-05-09
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor Qing, Quan

Abstract

Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

13.

DNA GRIDIRON COMPOSITIONS AND METHODS

      
Application Number 18228604
Status Pending
Filing Date 2023-07-31
First Publication Date 2024-05-09
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Han, Dongran
  • Yan, Hao

Abstract

Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.

IPC Classes  ?

  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C07H 1/00 - Processes for the preparation of sugar derivatives

14.

MONOCLONAL ANTIBODIES AGAINST SARS-COV-2 AND VARIANTS

      
Application Number 18500684
Status Pending
Filing Date 2023-11-02
First Publication Date 2024-05-09
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Chen, Qiang
  • Sun, Haiyan
  • Jugler, Collin

Abstract

The present invention provides monoclonal antibodies against SARS-CoV-2 and methods of use and making thereof.

IPC Classes  ?

  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • A01H 6/82 - Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
  • A61P 31/14 - Antivirals for RNA viruses
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

15.

TRACKING-BASED MOTION DEBLURRING VIA CODED EXPOSURE

      
Application Number 18516679
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-05-09
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Jayasuriya, Suren
  • Iqbal, Odrika
  • Spanias, Andreas

Abstract

Tracking-based motion deblurring via coded exposure is provided. Fast object tracking is useful for a variety of applications in surveillance, autonomous vehicles, and remote sensing. In particular, there is a need to have these algorithms embedded on specialized hardware, such as field-programmable gate arrays (FPGAs) or application-specific integrated circuits (ASICs), to ensure energy-efficient operation while saving on latency, bandwidth, and memory access/storage. In an exemplary aspect, an object tracker is used to track motion of one or more objects in a scene captured by an image sensor. The object tracker is coupled with coded exposure of the image sensor, which modulates photodiodes in the image sensor with a known exposure function (e.g., based on the object tracking). This allows for motion blur to be encoded in a characteristic manner in image data captured by the image sensor. Then, in post-processing, deblurring is performed using a computational algorithm.

IPC Classes  ?

  • G06T 7/20 - Analysis of motion
  • G06T 5/73 - Deblurring; Sharpening
  • H04N 23/73 - Circuitry for compensating brightness variation in the scene by influencing the exposure time

16.

Prediction of binding from binding data in peptide and other arrays

      
Application Number 16029965
Grant Number 11978534
Status In Force
Filing Date 2018-07-09
First Publication Date 2024-05-07
Grant Date 2024-05-07
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor Woodbury, Neal

Abstract

Systems, devices and methods for predicting binding on an array such as a peptide array. Certain methods utilize a peptide array having a plurality of peptides with one or more defined parameters and contacting the peptide array with a training sample containing one or more molecules of interest. Interactions between the plurality of peptides and the one or more molecules of interest are processed according to a data fitting model, which model is then is applied to interactions between the plurality of peptides and a test sample to predict binding associated with the one or more molecules of interest.

IPC Classes  ?

  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

17.

SYSTEM AND METHOD FOR MRNA QUANTIFICATION PROCESSING IN-MEMORY

      
Application Number 18187203
Status Pending
Filing Date 2023-03-21
First Publication Date 2024-05-02
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Fan, Deliang
  • Zhang, Fan
  • Angizi, Shaahin

Abstract

A method of calculating an abundance of an mRNA sequence within a gene comprises storing an index table of the gene in a non-volatile memory, obtaining a short read of the mRNA sequence, generating a set of input fragments from the mRNA sequence, initializing a compatibility table in a volatile memory, for each input fragment in the set of input fragments, searching for an exact match of the input fragment in the index table, calculating a final result from the compatibility table, and calculating an abundance of the mRNA sequence in the gene by aggregating the transcripts compatible with the short read, wherein the calculating step is performed on the same integrated circuit as the non-volatile memory. A system for in-memory calculation of an abundance of an mRNA sequence within a gene is also disclosed.

IPC Classes  ?

  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

18.

METHOD AND SYSTEM FOR A PROGRAMMABLE AND GENERIC PROCESSING-IN-SRAM ACCELERATOR

      
Application Number 18499643
Status Pending
Filing Date 2023-11-01
First Publication Date 2024-05-02
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Fan, Deliang
  • Angizi, Shaahin

Abstract

A system for in-memory computing comprises a volatile memory comprising at least a first layered subarray, wherein each subarray comprises a plurality of memory cells, and a plurality of sub-sense amplifiers connected to a read bitline of the first subarray of the memory, configured to compare a measured voltage of the read bitline to at least one threshold and provide at least one binary output corresponding to a logic operation based on whether the voltage of the read bitline is above or below the threshold. A method for in-memory computing is also disclosed.

IPC Classes  ?

  • G11C 11/419 - Read-write [R-W] circuits
  • G11C 11/412 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells with positive feedback, i.e. cells not needing refreshing or charge regeneration, e.g. bistable multivibrator or Schmitt trigger using field-effect transistors only
  • H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one output; Inverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits

19.

ORAL BOTANICAL COMPOSITION

      
Application Number 18277043
Status Pending
Filing Date 2022-02-11
First Publication Date 2024-04-25
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • SOUTHWEST COLLEGE OF NATUROPATHIC MEDICINE (USA)
Inventor
  • Langland, Jeffrey Olaf
  • Jacobs, Bertram

Abstract

This invention is directed to oral botanical compositions comprising plant extracts, methods of preparing the same, and methods of using the same for treating an infection.

IPC Classes  ?

20.

MEMBRANE-BASED OPTOMECHANICAL ACCELEROMETER, METHODS OF MAKING THE SAME AND SYSTEMS USING THE SAME

      
Application Number 18277196
Status Pending
Filing Date 2022-02-11
First Publication Date 2024-04-25
Owner Arizona Board of Regents (USA)
Inventor
  • Wilson, Dalziel
  • Agrawal, Aman Rajendra

Abstract

The present disclosure provides an optomechanical accelerometer that includes a first membrane having a first susceptibility; a second membrane having a second susceptibility that is greater than the first susceptibility; and at least one support member; wherein: the second membrane is supported above the first membrane by the at least one support member, such that the first and second membranes form at least a portion of an optical cavity.

IPC Classes  ?

  • G01P 15/093 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values by photoelectric pick-up

21.

DETECTION AND MONITORING OF DOSAGE DELIVERY FOR VAPORIZED WAXES, SOLIDS OR VISCOUS OILS, AND CANNABINOIDS

      
Application Number 18330040
Status Pending
Filing Date 2023-06-05
First Publication Date 2024-04-25
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Garcia, Antonio
  • Santello, Marco
  • Woolley, Christine

Abstract

A sensing module for monitoring dosage delivery of a vaporized material, and a portable vaporization unit including the sensing module, include a light sensor that detects disruptions in a light path across a vapor channel, the disruptions caused by the vaporized material flowing through the vapor channel. The light sensor includes a UV light source, which may emit 370 nm wavelength light, and a UV light detector that converts intensity of incident light in the light path into a signal. A microprocessor of the sensing module compares the signal to a baseline measurement to determine the concentration of a medicament in the vapor; then, using the flow rate and activation time of the device, the microprocessor determines the dosage and can perform monitoring and reporting actions based on the dosage. A measuring circuit measures fluctuations in resistance/impedance of a vaporization element to further determine flow rate and/or dosage.

IPC Classes  ?

22.

OLED efficency and lifetime with doped electron blocking layer

      
Application Number 18481044
Status Pending
Filing Date 2023-10-04
First Publication Date 2024-04-25
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Li, Jian
  • Li, Lin Song

Abstract

Disclosed herein is a hybrid inorganic-organic light emitting device that can include a cathode; an anode; at least one organic layer disposed between the cathode and the anode, wherein the at least one organic layer comprises an emissive material; at least one additional layer selected from the group consisting of an electron injection layer, an electron transport layer, and a hole blocking layer; wherein the at least one additional layer is disposed between the cathode and the at least one organic layer; and wherein the at least one additional layer comprises at least one metal oxide. Also disclosed are consumer products comprising this hybrid inorganic-organic light emitting device.

IPC Classes  ?

  • H10K 50/17 - Carrier injection layers
  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
  • H10K 50/165 - Electron transporting layers comprising dopants
  • H10K 50/18 - Carrier blocking layers

23.

ANALOG-TO-DIGITAL CONVERTER (ADC) ARCHITECTURES FOR HIGH RESOLUTION AND ENERGY EFFICIENCY

      
Application Number 18490931
Status Pending
Filing Date 2023-10-19
First Publication Date 2024-04-25
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor Sanyal, Arindam

Abstract

A low-pass and band-pass delta-sigma (ΔΣ) analog-to-digital converter (ADC) device for sensor interface is disclosed. The device includes a first stage comprising a low-resolution passive integrator-based noise-shaping successive approximation register (SAR) ADC and a second stage comprising a voltage-controlled oscillator (VCO)-ADC.

IPC Classes  ?

  • H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter
  • H03M 1/06 - Continuously compensating for, or preventing, undesired influence of physical parameters
  • H03M 1/20 - Increasing resolution using an n bit system to obtain n + m bits, e.g. by dithering

24.

SYSTEMS AND METHODS FOR PREDICTING WHICH SOFTWARE VULNERABILITIES WILL BE EXPLOITED BY MALICIOUS HACKERS TO PRIORITIZE FOR PATCHING

      
Application Number 18496880
Status Pending
Filing Date 2023-10-29
First Publication Date 2024-04-25
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Shakarian, Paulo
  • Almukaynizi, Mohammed
  • Shakarian, Jana
  • Nunes, Eric
  • Dharaiya, Krishna
  • Senguttuvan, Manoj Balasubramaniam
  • Grimm, Alexander

Abstract

Various embodiments for predicting which software vulnerabilities will be exploited by malicious hackers and hence prioritized by patching are disclosed.

IPC Classes  ?

  • G06F 11/00 - Error detection; Error correction; Monitoring
  • G06F 18/214 - Generating training patterns; Bootstrap methods, e.g. bagging or boosting
  • G06F 18/24 - Classification techniques
  • G06F 21/54 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by adding security routines or objects to programs
  • G06F 21/55 - Detecting local intrusion or implementing counter-measures
  • G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities

25.

SYSTEMS AND METHODS FOR IMPROVING ANGLE ESTIMATION ACCURACY FOR MILLIMETER-WAVE RADARS

      
Application Number 18491367
Status Pending
Filing Date 2023-10-19
First Publication Date 2024-04-25
Owner
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
  • Texas Instruments Incorporated (USA)
Inventor
  • Ozev, Sule
  • Ataman, Ferhat C.
  • Kumar Y.B., Chethan
  • Rao, Sandeep

Abstract

A radar system applies various angle correction processes with varying levels of computational overhead to reduce errors in angle estimation when processing received return signals. The various angle correction processes aim to overcome systematic errors affected by range migration through correction based on simulation or hardware measurements, through non-iterative refinement, iterative refinement, and/or a combination of correction and iterative refinement.

IPC Classes  ?

  • G01S 13/42 - Simultaneous measurement of distance and other coordinates
  • G01S 7/35 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group - Details of non-pulse systems

26.

METHODS AND DEVICES FOR MODULATING CELLULAR ACTIVITY USING ULTRASOUND

      
Application Number 18335541
Status Pending
Filing Date 2023-06-14
First Publication Date 2024-04-25
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor Tyler, William James P.

Abstract

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

IPC Classes  ?

  • A61N 7/00 - Ultrasound therapy
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/369 - Electroencephalography [EEG]
  • A61B 5/372 - Analysis of electroencephalograms
  • A61N 5/06 - Radiation therapy using light
  • C12N 5/0793 - Neurons
  • C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

27.

TEMPORAL TRAUMATIC BRAIN INJURY BIOMARKERS AND METHODS OF USE THEREOF

      
Application Number 18480489
Status Pending
Filing Date 2023-10-02
First Publication Date 2024-04-25
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Martinez, Briana
  • Stabenfeldt, Sarah
  • Diehnelt, Christopher
  • Stephanopoulos, Nicholas
  • Willingham, Crystal
  • Witten, Amanda
  • Lundgreen, Kendall

Abstract

A unique pipeline is employed for biomarker discovery that entailed domain antibody phage display, next generation sequencing analysis, and nanotechnology strategies to generate antibody mimetics are disclosed. Also disclosed are the temporal biomarkers of traumatic brain injury and their methods of use. In some embodiments, the temporal biomarkers are synthetic peptides comprising the HCDR3 sequences identified using the disclosed pipeline. In some aspects, the synthetic peptides have less than 30 amino acid residues and comprise a biotin scaffold that is linked to the HCDR3 sequences.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

28.

SYSTEMS AND METHODS FOR AGILE AND EXPLAINABLE OPTIMIZATION OF EFFICIENT HARDWARE/SOFTWARE CODESIGNS FOR DOMAIN-SPECIFIC COMPUTING SYSTEMS USING BOTTLENECK ANALYSIS

      
Application Number 18485811
Status Pending
Filing Date 2023-10-12
First Publication Date 2024-04-25
Owner
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
  • University of California (USA)
Inventor
  • Dave, Shail
  • Shrivastava, Aviral
  • Nowatzki, Tony

Abstract

A system applies bottleneck analysis for design and optimization of computing systems. In particular, the system constructs a bottleneck model, including a bottleneck cost graph for a workload or a function, through which factors corresponding to the execution costs of an arbitrary processor can be modeled. By using the bottleneck analysis, the system can determine bottleneck factors for an obtained cost value (e.g., time taken by an application's execution on a processor) and can reason about obtained high cost. The system determines and uses information about parameters impacting bottlenecks for execution costs and their approximate relationship with the bottlenecks to produce an optimized hardware-software configuration for execution of one or more workloads. Systematic, bottleneck-guided analysis and optimization can introduce explainability in the design and optimization process and can achieve more efficient design configurations much faster.

IPC Classes  ?

  • G06F 11/34 - Recording or statistical evaluation of computer activity, e.g. of down time, of input/output operation
  • G06F 8/41 - Compilation

29.

SYSTEM AND METHOD FOR LEARNING SPARSE FEATURES FOR SELF-SUPERVISED LEARNING WITH CONTRASTIVE DUAL GATING

      
Application Number 18494330
Status Pending
Filing Date 2023-10-24
First Publication Date 2024-04-25
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Seo, Jae-Sun
  • Meng, Jian
  • Yang, Li
  • Fan, Deliang

Abstract

A method of training a machine learning algorithm comprises providing a set of input data, performing transforms on the input data to generate augmented data, to provide transformed base paths into machine learning algorithm encoders, segmenting the augmented data, calculating main base path outputs by applying a weighting to the segmented augmented data, calculating pruning masks from the input and augmented data to apply to the base paths of the machine learning algorithm encoders, the pruning masks having a binary value for each segment in the segmented augmented data, calculating sparse conditional path outputs by performing a computation on the segments of the segmented augmented data, and calculating a final output as a sum of the main base path outputs and the sparse conditional path outputs. A computer-implemented system for learning sparse features of a dataset is also disclosed.

IPC Classes  ?

30.

COMPOSITE MATERIAL WITH SIDE-EMITTING OPTICAL FIBERS

      
Application Number 18482265
Status Pending
Filing Date 2023-10-06
First Publication Date 2024-04-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Westerhoff, Paul K.
  • Rho, Hojung

Abstract

A composite material includes one or more side-emitting optical fibers arranged in a pattern defining openings bounded at least in part by the one or more side-emitting optical fibers. The one or more side-emitting optical fibers have a UV-C transparent coating, and at least one of the one or more side-emitting optical fibers is configured to be coupled to a light-emitting diode. A reverse osmosis filter includes a reverse osmosis membrane and the composite material coupled to the reverse osmosis membrane.

IPC Classes  ?

31.

FRAMEWORK FOR CYBER RISK LOSS DISTRIBUTION OF HOSPITAL INFRASTRUCTURE: BOND PERCOLATION OF MIXED RANDOM GRAPHS APPROACH

      
Application Number 18132918
Status Pending
Filing Date 2023-04-10
First Publication Date 2024-04-18
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Chiaradonna, Stefano
  • Jevtic, Petar
  • Lanchier, Nicolas

Abstract

A computing system includes a processor having access to data associated with a plurality of devices of a network. The processor is configured to leverage the data to execute a loss model that estimates cyber risk loss distribution of the network associated with healthcare environment and infrastructure using bond percolation on a mixed random graphs approach.

IPC Classes  ?

32.

SYSTEM AND METHOD FOR AUTOMATIC VAGUS NERVE STIMULATION FOR POST-STROKE REHABILITATION

      
Application Number 18399547
Status Pending
Filing Date 2023-12-28
First Publication Date 2024-04-18
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Rangarajan, Vishak
  • Dhooge, Devin
  • Sheleg, Kiryl
  • Holmes, Nicholas
  • Kleim, Jeffrey
  • Greger, Bradley
  • Shukla, Shivanshi

Abstract

A system and method for the automatic stimulation of a vagus nerve for post-stroke rehabilitation is disclosed. The system includes an application subsystem having an electrode positioned to stimulate the vagus nerve and coupled to a user outside of a surgical setting. The system also includes a waveform generator communicatively coupled to the electrode, and a triggering subsystem including a receiver configured to detect the presence of a tag. The triggering subsystem is communicatively coupled to waveform generator and is configured to automatically trigger the stimulation of the vagus nerve upon detecting the presence of the tag. The tag is located proximate a rehabilitation context such that the tag is detected when the user is using the rehabilitation context, resulting in the vagus nerve of the user being automatically stimulated by the electrode in response to the user's post-stroke rehabilitation training.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/04 - Electrodes
  • A61N 5/06 - Radiation therapy using light

33.

Alkali ION Conducting Plastic Crystals

      
Application Number 18330948
Status Pending
Filing Date 2023-06-07
First Publication Date 2024-04-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Angell, Charles Austen
  • Klein, Iolanda Santana
  • Tucker, Telpriore Greg

Abstract

A solid electrolyte represented by general formula LiySiRx(MO4), where x is an integer from 1 to 3 inclusive, y=4−x, each R present is independently C1-C3 alkyl or C1-C3 alkoxy, and M is sulfur, selenium, or tellurium. Methods of making the solid electrolyte include combining a phenylsilane and a first acid to yield mixture including benzene and a second acid, and combining at least one of an alkali halide, and alkali amide, and an alkali alkoxide with the second acid to yield a product d represented by general formula LiySiRx(MO4)y. The second acid may be in the form of a liquid or a solid. The phenylsilane includes at least one C1-C3 alkyl substituent or at least one C1-C3 alkoxy substituent, and the first acid includes at least one of sulfuric acid, selenic acid, and telluric acid.

IPC Classes  ?

  • H01M 10/0564 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes the electrolyte being constituted of organic materials only
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries

34.

SYNTHETIC IMMUNOMODULATION WITH A CRISPR SUPER-REPRESSOR IN VIVO

      
Application Number 18535658
Status Pending
Filing Date 2023-12-11
First Publication Date 2024-04-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Kiani, Samira
  • Ebrahimkhani, Mo Reza
  • Moghadam, Farzaneh

Abstract

Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia.

IPC Classes  ?

  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/86 - Viral vectors

35.

SYSTEM, METHOD, AND DEVICE FOR CONTINUOUS CO2 CAPTURE USING A CO2 PUMP MEMBRANE

      
Application Number 18263691
Status Pending
Filing Date 2022-02-01
First Publication Date 2024-04-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Green, Matthew
  • Lackner, Klaus

Abstract

A continuous CO2 capture system, method, and device are disclosed. The device includes a CO2 pump membrane including a moisture-swing material, and a cavity having a first fluid. The CO2 pump membrane separates the first fluid from a second fluid, the fluids creating a water concentration gradient across the membrane and transport of water through the membrane. The water concentration gradient creates a carbon concentration gradient across the membrane that decreases moving from outside the cavity to inside the cavity. As water is continuously transported from the first fluid to the second fluid through the CO2 pump membrane because of the water concentration gradient, carbon dioxide is continuously captured from the second fluid by the moisture-swing material of the CO2 pump membrane and continuously pumped along the carbon concentration gradient across the CO2 pump membrane and into the first fluid within the cavity.

IPC Classes  ?

  • B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion

36.

CRITICAL ANGLE REFLECTION IMAGING FOR QUANTIFICATION OF MOLECULAR INTERACTIONS

      
Application Number 18265057
Status Pending
Filing Date 2021-12-06
First Publication Date 2024-04-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Wang, Shaopeng
  • Liang, Runli
  • Ma, Guangzhong

Abstract

This disclosure describes systems and methods for critical angle reflection (CAR) imaging to quantify molecular binding kinetics on a glass surface in some embodiments. CAR is a label-free method that measures the reflectivity change near a critical angle in response to molecular binding induced refractive index changes on the sensor surface. The sensitivity and dynamic range of CAR is tunable by varying the incident angle of light, which allows for optimizing the measurement for ligands with different sizes in both biomolecular and cell-based studies.

IPC Classes  ?

  • G01N 21/43 - Refractivity; Phase-affecting properties, e.g. optical path length by measuring critical angle
  • G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

37.

COBALT-COPPER NANOENABLED ELECTRODES

      
Application Number 18321991
Status Pending
Filing Date 2023-05-23
First Publication Date 2024-04-04
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Cerron Calle, Gabriel
  • Dos Santos Fajardo, Ana
  • Garcia-Segura, Sergio
  • Sanchez, Carlos M.

Abstract

A nanocomposite electrode includes a porous copper substrate, Co3O4 and/or Cu/Co(OH)x nanoparticles electrolytically deposited on the porous copper substrate. Fabricating the nanocomposite electrode includes contacting the porous copper substrate with a solution comprising cobalt, and electrodepositing the cobalt on the porous copper substrate to yield the nanocomposite electrode. Reducing nitrate to ammonia includes contacting the nanocomposite electrode with an aqueous solution comprising nitrate, and electrocatalytically reducing the nitrate to yield ammonia.

IPC Classes  ?

  • C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
  • C25B 1/27 - Ammonia
  • C25B 11/031 - Porous electrodes
  • C25B 11/061 - Metal or alloy

38.

DYNAMIC ADAPTIVE SCHEDULING FOR ENERGY-EFFICIENT HETEROGENEOUS SYSTEMS-ON-CHIP AND RELATED ASPECTS

      
Application Number 18470177
Status Pending
Filing Date 2023-09-19
First Publication Date 2024-03-28
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • WISCONSIN ALUMNI RESEARCH FOUNDATION (USA)
  • UNIVERSITY OF ARIZONA (USA)
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
  • Chakrabarti, Chaitali
  • Ogras, Umit
  • Goksoy, Ahmet
  • Krishnakumar, Anish
  • Akoglu, Ali
  • Hassan, Md Sahil
  • Marculescu, Radu
  • Farcas, Allen-Jasmin

Abstract

Provided herein are dynamic adaptive scheduling (DAS) systems. In some embodiments, the DAS systems include a first scheduler, a second scheduler that is slower than the first scheduler, and a runtime preselection classifier that is operably connected to the first scheduler and the second scheduler, which runtime preselection classifier is configured to effect selective use of the first scheduler or the second scheduler to perform a given scheduling task. Related systems, computer readable media, and additional methods are also provided.

IPC Classes  ?

  • G06F 9/48 - Program initiating; Program switching, e.g. by interrupt
  • G06F 9/54 - Interprogram communication

39.

SYSTEMS AND METHODS FOR VOLUMETRIC MEASUREMENT OF MAXIMAL ALLOWABLE WORKING VOLUME WITHIN A SURGICAL CORRIDOR

      
Application Number 18525693
Status Pending
Filing Date 2023-11-30
First Publication Date 2024-03-28
Owner
  • Dignity Health (USA)
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Houlihan, Lena Mary
  • Naughton, David
  • Preul, Mark C.

Abstract

Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.

IPC Classes  ?

  • A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
  • A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery

40.

SILICA-BASED CHROMATOGRAPHIC PROCESSES FOR ISOLATING NUCLEIC ACID-PROTEIN COMPLEXES AND DETECTING TARGET NUCLEIC ACIDS

      
Application Number 18255731
Status Pending
Filing Date 2021-12-02
First Publication Date 2024-03-28
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Anderson, Karen
  • Knappenberger, Mark
  • Arockiam, Siril

Abstract

The disclosure relates to methods of detecting a target nucleic acid in a sample using a deactivated RNA-guided nuclease and guide RNA complex. Some methods relate to isolating protein-nucleic acid complexes using silica-based chromatography with certain buffered solutions to better prevent complex dissociation. Some methods relate to isolating protein-nucleic acid complexes using a tagged ribonucleoprotein which binds to a target nucleic acid to form a detectable interconnected network comprising the target nucleic acid. Also provided herein are primer nucleic acids, buffer solutions, and kits for performing the methods of this disclosure for detecting a target nucleic acid in a sample.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

41.

SYSTEMS AND METHODS FOR BIOLOGICAL TRANSFORMATION, CONCENTRATION, AND RECOVERY OF SELENIUM FROM WASTEWATER

      
Application Number 18255858
Status Pending
Filing Date 2021-12-03
First Publication Date 2024-03-28
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
  • Boltz, Joshua
  • Rittmann, Bruce
  • Daigger, Glen
  • Katz, Lynn

Abstract

The present invention relates to methods for biological wastewater treatment for Se control in Se-laden wastewater. The Se contaminants in the wastewater include the Se oxyanions selenate (SeO42-) and selenite (HSeO3−), which are biochemically reduced and transformed to elemental selenium (Se0) by microorganisms through anaerobic biological reduction. The resulting Se0 is entrained in the biomass, which is further processed to enable the efficient recovery of concentrated Se0.

IPC Classes  ?

  • C02F 9/00 - Multistage treatment of water, waste water or sewage
  • B01D 71/02 - Inorganic material

42.

IDENTIFICATION OF SEIZURE ONSET ZONE IN FUNCTIONAL MAGNETIC RESONANCE IMAGING

      
Application Number 18474098
Status Pending
Filing Date 2023-09-25
First Publication Date 2024-03-28
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Banerjee, Ayan
  • Gupta, Sandeep
  • Boerwinkle, Varina

Abstract

A system and associated methods for accurate localization of seizure onset zone (SOZ) from independent components (IC) of resting state functional magnetic resonance imaging (rs-fMRI) to improve surgical outcomes in children with Drug Resistant Epilepsy (DRE) are disclosed. The system and methods define a phased approach, where fMRI noise-related biomarkers are used through high fidelity image processing techniques to eliminate noise ICs. Then SOZ markers are used through a maximum likelihood-based classifier to determine SOZ localizing ICs.

IPC Classes  ?

  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G06T 7/00 - Image analysis

43.

PHOTOSYSTEM I-BACTERIAL HYDROGENASE CHIMERAS FOR HYDROGEN PRODUCTION

      
Application Number 18349764
Status Pending
Filing Date 2023-07-10
First Publication Date 2024-03-21
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Redding, Kevin
  • Kanygin, Andrey

Abstract

Provided herein, in some embodiments, are engineered cells and use of the same for increased hydrogen production. In particular, provided herein are genetically engineered cells comprising a polynucleotide encoding a fusion protein comprising a photosystem I (PSI) protein and a bacterial hydrogenase, as well as methods for producing such genetically engineered cells. Also provided herein are methods for increasing hydrogen (H2) production in cells.

IPC Classes  ?

  • C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
  • C07K 14/405 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
  • C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
  • C12N 15/62 - DNA sequences coding for fusion proteins

44.

CRISPR-CAS /TRANSCRIPTION FACTOR-BASED COMPETITION ASSAY FOR DETECTION OF MOLECULAR ANALYTES

      
Application Number 18463628
Status Pending
Filing Date 2023-09-08
First Publication Date 2024-03-21
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Green, Alexander
  • Chaudhary, Soma
  • Swingle, Kirstie

Abstract

Provided herein are highly modular and sensitive biosensors for small molecule detection using CRISPR/C as enzymes having collateral single-stranded nucleic acid cleavage activity. Also provided herein are uses of the biosensors in detection platforms for convenient, low-cost assessment of safety and purity of consumable samples, environmental samples, and agricultural products.

IPC Classes  ?

  • G01N 33/94 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics
  • C12Q 1/6823 - Release of bound markers
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

45.

METHOD AND SYSTEM FOR A TEMPERATURE-RESILIENT NEURAL NETWORK TRAINING MODEL

      
Application Number 18463778
Status Pending
Filing Date 2023-09-08
First Publication Date 2024-03-21
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Seo, Jae-Sun
  • Meng, Jian
  • Yang, Li
  • Fan, Deliang

Abstract

A method for increasing the temperature-resiliency of a neural network, the method comprising loading a neural network model into a resistive nonvolatile in-memory-computing chip, training the deep neural network model using a progressive knowledge distillation algorithm as a function of a teacher model, the algorithm comprising injecting, using a clean model as the teacher model, low-temperature noise values into a student model and changing, now using the student model as the teacher model, the low-temperature noises to high-temperature noises, and training the deep neural network model using a batch normalization adaptation algorithm, wherein the batch normalization adaptation algorithm includes training a plurality of batch normalization parameters with respect to a plurality of thermal variations.

IPC Classes  ?

  • G06N 3/08 - Learning methods
  • G06N 3/0495 - Quantised networks; Sparse networks; Compressed networks

46.

COMPOSITIONS AND METHODS OF USE OF SYNTHETIC PEPTIDES WITH MYCOBACTERIUM ABSCESSUS INHIBITORY ACTIVITY

      
Application Number 18464846
Status Pending
Filing Date 2023-09-11
First Publication Date 2024-03-21
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Haydel, Shelley
  • Diehnelt, Christopher

Abstract

Synthetic antimicrobial peptides, compositions comprising thereof, and methods of use for modulating one or more symptoms of an infection in a subject are disclosed. In some aspects, the infection is caused by mycobacteria, for example, a nontuberculous mycobacterium such as Mycobacterium abscessus. In other aspects, the infection is caused by Escherichia coli, Pseudomonas aeruginosa, or methicillin-resistant Staphylococcus aureus (MRSA). Also disclosed are methods of identifying synthetic antimicrobial peptides against a pathogen with no known effective treatment using a library of synthetic peptides.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
  • A61P 31/04 - Antibacterial agents
  • C12Q 1/18 - Testing for antimicrobial activity of a material

47.

ANTIBODY FUSION PROTEIN AND RELATED COMPOSITIONS FOR TARGETING CANCER

      
Application Number 18480038
Status Pending
Filing Date 2023-10-03
First Publication Date 2024-03-21
Owner
  • Dignity Health (USA)
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Sirianni, Rachael
  • Cook, Rebecca
  • Mor, Tsafrir
  • Blattman, Joseph

Abstract

Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61P 35/00 - Antineoplastic agents
  • C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C12N 15/86 - Viral vectors

48.

SYSTEMS AND METHODS FOR DIAGNOSING NEURODEGENERATIVE DISEASES

      
Application Number 18263503
Status Pending
Filing Date 2022-01-28
First Publication Date 2024-03-21
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Huseby, Carol J.
  • Coleman, Paul

Abstract

A processor is configured to implement a machine learning model that is trained to select transcripts in blood for distinguishing neurodegenerative diseases. The algorithm is developed via machine learning and leverages concepts associated with blood-based changes in mRNA gene expression for differentiating patients of any neurodegenerative disease regardless of the proteins or their post-translational modifications occurring in disease.

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G06N 20/20 - Ensemble learning
  • G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
  • G16B 40/20 - Supervised data analysis
  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

49.

SYSTEMS AND METHODS FOR PREDICTING MICROHARDNESS PROPERTIES OF WELDS

      
Application Number 17933495
Status Pending
Filing Date 2022-09-20
First Publication Date 2024-03-21
Owner
  • GM GLOBAL TECHNOLOGY OPERATIONS LLC (USA)
  • Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Lu, Ying
  • Ma, Junjie
  • Wang, Hui-Ping
  • Poirier, Mitchell
  • Yang, Baixuan
  • Oswald, Jay

Abstract

Systems and methods are provided for predicting microhardness properties of a weld that defines a weld joint between at least two workpieces. The system includes a processor programmed to: receive temperature data that includes temperature values each attributed to a corresponding one of a plurality of points of the weld at corresponding times during a welding process used to produce the weld, determine peak temperature values and cooling rate values for each of the points of the weld based on the temperature values, predict a three-dimensional (3D) distribution of microhardness values of the weld based on a machine learning method that evaluates the peak temperature values and the cooling rate values, and generate display data based on the 3D distribution of microhardness values.

IPC Classes  ?

  • G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
  • B23K 9/095 - Monitoring or automatic control of welding parameters

50.

SYSTEMS AND METHODS FOR ORIGAMI-INSPIRED WEARABLE ROBOTS FOR TRUNK SUPPORT

      
Application Number 18206496
Status Pending
Filing Date 2023-06-06
First Publication Date 2024-03-21
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Aukes, Daniel
  • Li, Dongting

Abstract

Systems and methods for a wearable “exo-shell” to improve the gait of elderly people during obstacle avoidance tasks are disclosed. With payload and energy expenditure as a main focus of this design, the present system leverages switchable, passive systems, in combination with lightweight materials that minimize additional metabolic costs, while remaining as “transparent” to the user as possible when inactive.

IPC Classes  ?

  • A61H 3/00 - Appliances for aiding patients or disabled persons to walk about

51.

ONCOLYTIC VIRUSES THAT EXPRESS MULTI-SPECIFIC IMMUNE CELL ENGAGERS

      
Application Number 17767856
Status Pending
Filing Date 2020-10-09
First Publication Date 2024-03-21
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Mcfadden, Douglas Grant
  • Torres-Dominguez, Lino
  • Villa, Nancy
  • Rahman, Mohammed Masmudur

Abstract

The disclosure provides Myxoma viruses that express one or more multi-specific immune cell engagers, such as BiKE, BiTE and/or MiTE and their use in inhibiting and/or treating a hematological cancer in a subject. The disclosure also provides a leukocyte having a Myxoma virus that expresses one or more multi-specific immune cell engagers, and the use of the leukocyte for inhibiting and/or treating a hematological cancer in a subject.

IPC Classes  ?

  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
  • A61K 35/768 - Oncolytic viruses not provided for in groups
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

52.

ONCOLYTIC VIRUS COMPRISING IMMUNOMODULATORY TRANSGENES AND USES THEREOF

      
Application Number 17767857
Status Pending
Filing Date 2020-10-09
First Publication Date 2024-03-21
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Mcfadden, Douglas Grant
  • Torres-Dominguez, Lino
  • Villa, Nancy
  • Rahman, Mohammed Masmudur

Abstract

The disclosure provides Myxoma virus that expresses one or more immunomodulatory transgenes and its use in inhibiting and/or treating a hematological cancer in a subject. The disclosure also provides a leukocyte having a Myxoma virus that expresses one or more immunomodulatory transgenes and the use of the leukocyte for inhibiting and/or treating a hematological cancer in a subject.

IPC Classes  ?

  • A61K 35/768 - Oncolytic viruses not provided for in groups
  • A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
  • A61P 33/00 - Antiparasitic agents

53.

SYSTEMS AND METHODS FOR PROBABILISTIC CONSENSUS ON FEATURE DISTRIBUTION FOR MULTI-ROBOT SYSTEMS WITH MARKOVIAN EXPLORATION DYNAMICS

      
Application Number 18244912
Status Pending
Filing Date 2023-09-11
First Publication Date 2024-03-21
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Shirsat, Aniket
  • Berman, Spring
  • Mishra, Shatadal
  • Zhang, Wenlong

Abstract

A consensus-based decentralized multi-robot approach is presented for reconstructing a discrete distribution of features, modeled as an occupancy grid map, that represent information contained in a bounded planar 2D environment, such as visual cues used for navigation or semantic labels associated with object detection. The robots explore the environment according to a random walk modeled by a discrete-time discrete-state (DTDS) Markov chain and estimate the feature distribution from their own measurements and the estimates communicated by neighboring robots, using a distributed Chernoff fusion protocol. Under this decentralized fusion protocol, each robot's feature distribution converges to the ground truth distribution in an almost sure sense.

IPC Classes  ?

  • G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
  • B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters
  • G05D 1/10 - Simultaneous control of position or course in three dimensions
  • G06V 10/84 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using probabilistic graphical models from image or video features, e.g. Markov models or Bayesian networks
  • G06V 20/17 - Terrestrial scenes taken from planes or by drones
  • H04W 4/46 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for vehicle-to-vehicle communication [V2V]

54.

DEVICE AND METHOD FOR PASSIVE COLLECTION OF ATMOSPHERIC CARBON DIOXIDE WITH ELECTRO-SWING MATERIALS

      
Application Number 18254971
Status Pending
Filing Date 2021-11-30
First Publication Date 2024-03-21
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Lackner, Klaus
  • Page, Robert

Abstract

A system, device, and method for passive collection of atmospheric carbon dioxide is disclosed. The device includes a release chamber having a sorbent regeneration system with a power supply, and a capture structure coupled to the release chamber, having a plurality of disks coupled to and spaced along at least one collapsible support. Each disk has an electro-swing sorbent material. The capture structure is movable between collection and release configurations. The collection configuration includes the capture structure extending upward to expose the structure to an airflow and allow the sorbent to capture atmospheric carbon dioxide while a collection voltage is established across the sorbent material. The release configuration includes the disks enclosed inside the release chamber and conductively coupled to the power supply such that a release voltage is established across the electro-swing sorbent material, resulting in the release of captured carbon dioxide forming an enriched gas.

IPC Classes  ?

  • B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
  • B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group

55.

SYSTEMS AND METHODS FOR AN ADAPTIVE AND REGION-SCALE PROPOSING MECHANISM FOR OBJECT RECOGNITION SYSTEMS

      
Application Number 18460053
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-03-21
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Farhadi, Mohammad
  • Yang, Yezhou
  • Santhosh Kumar Varma, Rahul

Abstract

Based on traffic images characteristics, a general pre-processing system and method reduces input size of neural network object recognition models to focus on necessary regions. The system includes a light neural network (binary or low precision; based on configuration) to detect target regions for further processing and applies a deeper model to those specific regions. The present disclosure provides experimentation results on various types of methods, such as conventional convolutional neural networks, transformers, and adaptive models, to show the scalability of the system.

IPC Classes  ?

  • G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 20/54 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects of traffic, e.g. cars on the road, trains or boats

56.

BITUMEN COMPOSITES WITH IMPREGNATED ZEOLITES

      
Application Number 18450535
Status Pending
Filing Date 2023-08-16
First Publication Date 2024-03-14
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Fini, Elham
  • Seo, Dong-Kyun
  • Aldagari, Sand
  • Mousavi, Masoumeh

Abstract

A bitumen composite includes an amine-impregnated zeolite and bitumen. Forming the bitumen composite includes combining bitumen and an amine-impregnated zeolite to yield a mixture, heating the mixture to yield the bitumen composite.

IPC Classes  ?

  • C08K 9/12 - Adsorbed ingredients
  • C01B 39/02 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
  • C08J 3/20 - Compounding polymers with additives, e.g. colouring
  • C08K 3/36 - Silica
  • C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch

57.

RAMAN SPECTROSCOPY SYSTEM FOR EXTREME CONDITIONS

      
Application Number 18463578
Status Pending
Filing Date 2023-09-08
First Publication Date 2024-03-14
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Birkel, Christina S.
  • Jamboretz, John
  • Reitz, Andreas

Abstract

A Raman spectroscopy probe includes a lens tube and an objective lens positioned in the lens tube. The lens tube and the objective lens are composed of microwave transparent materials. A Raman spectroscopy system includes the Raman spectroscopy probe, a microwave reactor having a microwave reactor chamber, a susceptor crucible positioned in the microwave reactor chamber, and a sample crucible positioned in the susceptor crucible. An end of the lens tube is configured to be positioned in the microwave reactor chamber to face an opening of the sample crucible. The Raman spectroscopy system can further include an optics assembly.

IPC Classes  ?

58.

SIMULTANEOUS QUANTIFICATION OF ANIONS USING ION CHROMATOGRAPHY AND SUPPRESSED ION CONDUCTIVITY DETECTION

      
Application Number 18456090
Status Pending
Filing Date 2023-08-25
First Publication Date 2024-03-07
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Krajmalnik-Brown, Rosa
  • Mohana Rangan, Srivatsan
  • Bowes, Devin

Abstract

Methods and systems for the detection and quantification of multiplicity of ionic analytes comprising bromide, phosphate, sulfite, thiosulfate, thiocyanate, and formate, and optionally fluoride, chloride, chromate, selenate, perchlorate, nitrate, nitrite, and sulfate, using ion chromatography and suppressed ion conductivity. The method comprises loading a sample loop with a sample; injecting the sample from the sample loop into a column with an eluent, wherein the column comprises a guard column and an analytical column; separating, with the column, the injected sample at an effective separation temperature the injected sample in the presence of an organic modifier into a multiplicity of detectable ionic analytes; suppressing, with a suppressor, background signal; and detecting, with a detector, the multiplicity of ionic analytes.

IPC Classes  ?

  • B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion

59.

SYSTEMS, METHODS, AND APPARATUSES FOR IMPLEMENTING PATCH ORDER PREDICTION AND APPEARANCE RECOVERY (POPAR) BASED IMAGE PROCESSING FOR SELF-SUPERVISED LEARNING MEDICAL IMAGE ANALYSIS

      
Application Number 18241809
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-03-07
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Pang, Jiaxuan
  • Haghighi, Fatemeh
  • Ma, Dongao
  • Islam, Nahid Ui
  • Hosseinzadeh Taher, Mohammad Reza
  • Liang, Jianming

Abstract

A self-supervised machine learning method and system for learning visual representations in medical images. The system receives a plurality of medical images of similar anatomy, divides each of the plurality of medical images into its own sequence of non-overlapping patches, wherein a unique portion of each medical image appears in each patch in the sequence of non-overlapping patches. The system then randomizes the sequence of non-overlapping patches for each of the plurality of medical images, and randomly distorts the unique portion of each medical image that appears in each patch in the sequence of non-overlapping patches for each of the plurality of medical images. Thereafter, the system learns, via a vision transformer network, patch-wise high-level contextual features in the plurality of medical images, and simultaneously, learns, via the vision transformer network, fine-grained features embedded in the plurality of medical images.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06T 7/11 - Region-based segmentation
  • G06V 10/54 - Extraction of image or video features relating to texture
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

60.

SYSTEMS, METHODS, AND APPARATUSES FOR IMPLEMENTING DISCRIMINATIVE, RESTORATIVE, AND ADVERSARIAL (DiRA) LEARNING USING STEPWISE INCREMENTAL PRE-TRAINING FOR MEDICAL IMAGE ANALYSIS

      
Application Number 18241811
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-03-07
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Guo, Zuwei
  • Islam, Nahid Ul
  • Liang, Jianming

Abstract

The system receives a plurality of medical images and integrates Self-Supervised machine Learning (SSL) instructions for performing a discriminative learning operation, a restorative learning operation, and an adversarial learning operation into a model for processing the received plurality of medical images. The model is configured with each of a discriminative encoder, a restorative decoder, and an adversarial encoder. Each of the discriminative encoder and the restorative decoder are configured to be skip connected, forming an encoder-decoder. Step-wise incremental training to incrementally train each of the discriminative encoder, the restorative decoder, and the adversarial encoder is performed, in particular: pre-training the discriminative encoder via discriminative learning; attaching the pre-trained discriminative encoder to the restorative decoder to configure the encoder-decoder as a pre-trained encoder-decoder; and training the pre-trained encoder-decoder of the model using joint discriminative and restorative learning. The pre-trained encoder-decoder is associated with the adversarial encoder. The pre-trained encoder-decoder associated with the adversarial encoder is trained through discriminative, restorative, and adversarial learning to render a trained model for the processing of the received plurality of medical images. The plurality of medical images are processed through the model using the trained model.

IPC Classes  ?

  • G06N 3/0895 - Weakly supervised learning, e.g. semi-supervised or self-supervised learning
  • G06N 3/0455 - Auto-encoder networks; Encoder-decoder networks
  • G06T 7/00 - Image analysis
  • G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 20/50 - Context or environment of the image
  • G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations

61.

SYSTEMS AND METHODS FOR SAFETY-GUARANTEED DRIVING CONTROL OF AUTOMATED VEHICLES VIA INTEGRATED CLFs AND CDBFs

      
Application Number 18242240
Status Pending
Filing Date 2023-09-05
First Publication Date 2024-03-07
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Chen, Yan
  • Huang, Yiwen

Abstract

A safety-guaranteed control system for automated vehicles (AVs) considers both vehicle and tire stabilities on varying road conditions. Conventional AV control systems may not be sufficient to adequately handle control-dependent and time-varying safety constraints. The system integrates control-dependent barrier functions (CDBF) and time-varying CBFs (TCBFs) with control Lyapunov functions (CLFs) in a quadratic programming problem.

IPC Classes  ?

  • B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles

62.

SYSTEMS AND METHODS FOR A POLICY-GOVERNED CONTENT MEDIATION MODEL FOR MOBILE AUGMENTED REALITY APPLICATIONS

      
Application Number 18461421
Status Pending
Filing Date 2023-09-05
First Publication Date 2024-03-07
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Rubio-Medrano, Carlos
  • Claramunt, Luis
  • Baek, Jaejong
  • Ahn, Gail-Joon

Abstract

A system implements a Policy-Governed Content Mediation Model for Mobile Augmented Reality (MAR) applications (MAR-Apps) by regulating the real-time interaction between digital MAR content, e.g., 3D objects displayed on top of a video stream, and the actual physical world. The system regulates the way MAR content is distributed inside physical spaces by means of the specification, evaluation, and enforcement of user-friendly authorization policies based on security-relevant information, a.k.a., attributes, ultimately resulting in the avoidance of unwanted content distribution and/or unwanted user interactions. Consequently, the system protects sensitive spaces as only authorized MAR content is authorized to merge with the physical surroundings. Additionally, the system allows benign multi-user interactions and respects the users' privacy by granting and enforcing management over user-supplied sensitive information.

IPC Classes  ?

  • G06T 19/00 - Manipulating 3D models or images for computer graphics
  • H04L 67/131 - Protocols for games, networked simulations or virtual reality
  • H04L 67/52 - Network services specially adapted for the location of the user terminal

63.

DEVICE FOR TUNING MICROFLUIDIC DROPLET FREQUENCY AND SYNCHRONIZING PHASE FOR SERIAL FEMTOSECOND CRYSTALLOGRAPHY

      
Application Number 18504091
Status Pending
Filing Date 2023-11-07
First Publication Date 2024-02-29
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Ros, Alexandra
  • Kim, Daihyun
  • Echelmeier, Austin
  • Cruz Villarreal, Jorvani
  • Egatz-Gomez, Ana
  • Quintana, Sebastian

Abstract

Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.

IPC Classes  ?

  • G01N 23/20025 - Sample holders or supports therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 3/02 - Burettes; Pipettes
  • B33Y 80/00 - Products made by additive manufacturing

64.

OIL-TREATED PLASTIC FOR CONCRETE

      
Application Number 18496614
Status Pending
Filing Date 2023-10-27
First Publication Date 2024-02-22
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Burton, Marvin
  • Hoover, Christian
  • Fini, Elham

Abstract

Treating plastic particles for use in concrete includes combining plastic particles with oil to yield a mixture, heating the mixture to yield a heated mixture, cooling the heated mixture to yield a cooled mixture, and removing excess oil from the cooled mixture to yield oil-treated plastic particles (e.g., oil-treated plastic particles for concrete). In one example, the oil is vegetable oil. The vegetable oil can be soybean oil, corn oil, canola oil, safflower oil, peanut oil, olive oil, grape seed oil, cocoa butter, palm oil, rice bran oil, or a combination thereof. The oil can be waste oil (e.g., waste vegetable oil, such as that recovered from restaurants). The plastic particles can be derived from post-consumer plastic, such as recycled plastic. In one example, the post-consumer plastic includes mixed plastics. A concrete composition can include rocks, sand, cement, and the oil-treated plastic particles.

IPC Classes  ?

  • C04B 18/30 - Mixed waste; Waste of undefined composition, e.g. municipal waste
  • B09B 3/21 - Agglomeration, binding or encapsulation of solid waste using organic binders or matrix
  • B09B 3/40 - Destroying solid waste or transforming solid waste into something useful or harmless involving thermal treatment, e.g. evaporation

65.

EFFICIENT INTEGRATION OF MANUFACTURING OF UPCYCLED CONCRETE PRODUCT INTO POWER PLANTS

      
Application Number 18222238
Status Pending
Filing Date 2023-07-14
First Publication Date 2024-02-22
Owner
  • The Regents of the University of California (USA)
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Sant, Gaurav
  • Pilon, Laurent G.
  • Wang, Bu
  • Neithalath, Narayanan
  • Wei, Zhenhua
  • Young, Benjamin
  • Falzone, Gabriel D.
  • Simonetti, Dante

Abstract

A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product.

IPC Classes  ?

  • C04B 7/19 - Portland cements
  • C04B 7/46 - Burning; Melting electric
  • C04B 7/38 - Preparing or treating the raw materials individually or as batches
  • C04B 9/20 - Manufacture, e.g. preparing the batches
  • C04B 40/02 - Selection of the hardening environment
  • C04B 7/36 - Manufacture of hydraulic cements in general
  • C04B 28/04 - Portland cements

66.

LITHIUM LANTHANUM ZIRCONATE THIN FILMS

      
Application Number 18493561
Status Pending
Filing Date 2023-10-24
First Publication Date 2024-02-15
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Chan, Candace
  • Weller, Jon Mark

Abstract

Forming a lithium lanthanum zirconate thin film includes disposing zirconium oxide on a substrate to yield a zirconium oxide coating, contacting the zirconium oxide coating with a solution including a lithium salt and a lanthanum salt, heating the substrate to yield a dried salt coating on the zirconium oxide coating, melting the dried salt coating to yield a molten salt mixture, reacting the molten salt mixture with the zirconium oxide coating to yield lithium lanthanum zirconate, and cooling the lithium lanthanum zirconate to yield a lithium lanthanum zirconate coating on the substrate. In some cases, the zirconium oxide coating is contacted with an aqueous molten salt mixture including a lithium salt and a lanthanum salt, the molten salt mixture is reacted with the zirconium oxide coating to yield lithium lanthanum zirconate, and the lithium lanthanum zirconate is cooled to yield a lithium lanthanum zirconate coating on the substrate.

IPC Classes  ?

  • C23C 22/70 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using melts
  • C23C 16/40 - Oxides
  • C23C 28/04 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and only coatings of inorganic non-metallic material
  • H01M 10/0562 - Solid materials
  • C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
  • C23C 22/05 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
  • C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material

67.

ANTIMICROBIAL SUSCEPTIBILITY TESTING WITH LARGE-VOLUME LIGHT SCATTERING IMAGING AND DEEP LEARNING VIDEO MICROSCOPY

      
Application Number 18494225
Status Pending
Filing Date 2023-10-25
First Publication Date 2024-02-15
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Tao, Nongjian
  • Wang, Shaopeng
  • Yu, Hui

Abstract

A method for deep learning video microscopy-based antimicrobial susceptibility testing of a bacterial strain in a sample by acquiring image sequences of individual bacterial cells of the bacterial strain in a subject sample before, during, and after exposure to each antibiotic at different concentrations. The image sequences are compressed into static images while preserving essential phenotypic features. Data representing the static images are input into a pre-trained deep learning (DL) model which generates output data; and antimicrobial susceptibility for the bacterial strain is determined from the output data.

IPC Classes  ?

  • C12Q 1/18 - Testing for antimicrobial activity of a material
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
  • G06T 7/00 - Image analysis

68.

SYSTEMS AND METHODS FOR A BAYESIAN SPATIOTEMPORAL GRAPH TRANSFORMER NETWORK FOR MULTI-AIRCRAFT TRAJECTORY PREDICTION

      
Application Number 18234124
Status Pending
Filing Date 2023-08-15
First Publication Date 2024-02-15
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor Liu, Yongming

Abstract

A system includes a Bayesian Spatiotemporal Graph Transformer (B-STAR) architecture that models spatial and temporal relationship of multiple agents under uncertainties. The system enables Multi-Agent Trajectory Prediction for safety-critical engineering applications, (e.g., autonomous driving and flight systems) and considers the impact of various sources, such as environmental conditions, pilot/controller behaviors, and potential conflicts with nearby aircraft. It is shown that B-STAR achieves state-of-the-art performance on the ETH/UCY pedestrian dataset with UQ competence.

IPC Classes  ?

  • G06N 3/047 - Probabilistic or stochastic networks
  • G06N 3/0455 - Auto-encoder networks; Encoder-decoder networks
  • G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

69.

ANTI-MICROBIAL ANTIBODY SIGNATURES OF INFLAMMATORY BOWEL DISEASE AND USES THEREOF

      
Application Number 18448685
Status Pending
Filing Date 2023-08-11
First Publication Date 2024-02-15
Owner
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
  • Mayo Foundation for Medical Education & Research (USA)
Inventor
  • Shome, Mahasish
  • Song, Lusheng
  • Chung, Yunro
  • Leighton, Jonathan
  • Labaer, Joshua
  • Qiu, Ji

Abstract

The present invention relates anti-microbial antibody signatures of inflammatory bowel disease and their use in early and accurate diagnosis of disease including ulcerative colitis (UC) and Crohn's disease (CD).

IPC Classes  ?

  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

70.

UNIMOLECULAR APTAMER-BASED SENSORS FOR PATHOGEN DETECTION

      
Application Number 18453129
Status Pending
Filing Date 2023-08-21
First Publication Date 2024-02-15
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Green, Alexander
  • Ma, Duo
  • Tang, Anli

Abstract

Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.

IPC Classes  ?

  • C12Q 1/6825 - Nucleic acid detection involving sensors
  • C12Q 1/6816 - Hybridisation assays characterised by the detection means

71.

ULTRASPECIFIC RIBOREGULATORS HAVING ROBUST SINGLE-NUCLEOTIDE SPECIFICITY AND IN VITRO AND IN VIVO USES THEREOF

      
Application Number 18311587
Status Pending
Filing Date 2023-05-03
First Publication Date 2024-02-08
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Green, Alexander
  • Hong, Fan

Abstract

Provided herein are highly sensitive compositions and methods for detection of at least one specific nucleic acid molecule in a sample. The presence of a specific nucleic acid provides a positive indicator of a pathogenic agent, contaminant, non-canonical bases, and/or wild-type or mutated genes in a sample or a cell. Applications for which the compositions and methods are particularly well suited include point-of-care disease diagnosis or cellular RNA imaging.

IPC Classes  ?

  • C12N 15/67 - General methods for enhancing the expression
  • C12Q 1/6825 - Nucleic acid detection involving sensors
  • C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

72.

ADDITIVE MANUFACTURING OF POLYMERIC MATERIAL WITH METALLIC STRUCTURES

      
Application Number 18358725
Status Pending
Filing Date 2023-07-25
First Publication Date 2024-02-08
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Tang, Tengteng
  • Li, Xiangjia

Abstract

Apparatuses, systems, and methods for electrical field-assisted heterogeneous material printing (EF-HMP) of metal-polymer composite structure include a printing platform, a solution tank, an optical projection system, and an electrical field generation and control module. An additive manufacturing method for a metal-polymer composite structure includes preparing a photocurable electrolyte solution by mixing a photocurable liquid resin with a conductive nanofiller, a metal salt solution, a photo initiator, and deionized water. The method further includes initiating photopolymerization of the photocurable liquid resin to form a photocured polymer matrix by directing a projection of ultraviolet light energy from a light source onto the photocurable electrolyte solution. The method further includes depositing a metal structure onto the photocured polymer matrix. In this manner, both the photopolymerization and the metal electrodeposition are performed using the same photocurable electrolyte solution.

IPC Classes  ?

  • C25D 1/00 - Electroforming
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor

73.

METHODS OF INCREASING BIOMASS PRODUCTIVITY IN ALGAE CULTURES

      
Application Number 18484359
Status Pending
Filing Date 2023-10-10
First Publication Date 2024-02-08
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Lammers, Peter
  • Seger, Mark
  • Park, Wonkun
  • Csakan, Nicholas

Abstract

The present disclosure relates to methods of culturing algae that overcomes catabolic repression of photosynthesis in mixotrophic growth.

IPC Classes  ?

  • C12N 1/12 - Unicellular algae; Culture media therefor
  • A01G 33/00 - Cultivation of seaweed
  • C12M 1/00 - Apparatus for enzymology or microbiology

74.

POLYMERIC MATERIALS FOR CARBON DIOXIDE CAPTURE

      
Application Number 18361657
Status Pending
Filing Date 2023-07-28
First Publication Date 2024-02-01
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Green, Matthew
  • Korah, Mani Modayil
  • Culp, Kyle

Abstract

A carbon dioxide capture composition includes a hydroxide-ion-exchanged poly(N-vinyl guanidine)-based polymer material as a sorbent. A method of preparing the carbon dioxide capture composition includes contacting a poly(N-vinyl guanidine)-based polymer material with hydroxide ion exchange beads, and exchanging hydroxide ion into the poly(N-vinyl guanidine)-based polymer material to form the sorbent. A carbon dioxide capture method includes contacting the sorbent with a gas stream, and sorbing carbon dioxide in the gas stream with the sorbent. A carbon dioxide capture system includes a sorption bed having a hydroxide-ion-exchanged poly(N-vinyl guanidine)-based polymer material as a sorbent.

IPC Classes  ?

  • B01D 53/62 - Carbon oxides
  • B01D 53/96 - Regeneration, reactivation or recycling of reactants
  • B01D 53/78 - Liquid phase processes with gas-liquid contact
  • B01D 53/30 - Controlling by gas-analysis apparatus
  • C08F 126/02 - Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
  • B01J 20/26 - Synthetic macromolecular compounds
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/34 - Regenerating or reactivating

75.

TUNABLE NANOSCALE CAGES FROM SELF-ASSEMBLING DNA AND PROTEIN BUILDING BLOCKS

      
Application Number 18485895
Status Pending
Filing Date 2023-10-12
First Publication Date 2024-02-01
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Stephanopoulos, Nicholas
  • Xu, Yang

Abstract

Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.

IPC Classes  ?

  • C12N 9/88 - Lyases (4.)
  • C07K 19/00 - Hybrid peptides
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof

76.

SYSTEM AND METHOD FOR NEURAL NETWORK MULTIPLE TASK ADAPTATION

      
Application Number 18360140
Status Pending
Filing Date 2023-07-27
First Publication Date 2024-02-01
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Fan, Deliang
  • Zhang, Fan
  • Yang, Li

Abstract

A neural network accelerator architecture for multiple task adaptation comprises a volatile memory comprising a plurality of subarrays, each subarray comprising M rows and N columns of volatile memory cells; a source line driver connected to a plurality of N source lines, each source line corresponding to a column in the subarray; a binary mask buffer memory having size at least N bits, each bit corresponding to a column in the subarray, where a 0 corresponds to turning off the column for a convolution operation and a 1 corresponds to turning on the column for the convolution operation; and a controller configured to selectively drive each of the N source lines with a corresponding value from the mask buffer; wherein each column in the subarray is configured to store a convolution kernel.

IPC Classes  ?

  • G06N 3/08 - Learning methods
  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

77.

Implantable Platforms For Transcranial And Long-Range Optogenetics

      
Application Number 18225480
Status Pending
Filing Date 2023-07-24
First Publication Date 2024-01-25
Owner Arizona Board of Regents (USA)
Inventor Gutruf, Philipp

Abstract

The present disclosure provides an implantable optogenetic stimulation device. In one embodiment the device includes a housing and an optoelectronic stimulation circuit for light delivery for optogenetic stimulation. The stimulation circuit includes energy harvesting circuitry to receive radio frequency (RF) energy; one or more capacitor storage elements to store energy associated with the RF energy; a light emitting diode (LED) to generate a light source for optogenetic stimulation at a selected frequency and duty cycle; and controller circuitry to discharge the one or more capacitor storage elements at a selected duty cycle to cause the LED to generate pulsed light at the selected duty cycle with energy requirement above the peak power capability of the RF harvesting circuit.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/40 - Applying electric fields by inductive or capacitive coupling

78.

SYSTEM AND METHOD FOR RESOURCE-EFFICIENT CARBON DIOXIDE CAPTURE

      
Application Number 18255077
Status Pending
Filing Date 2021-12-08
First Publication Date 2024-01-25
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Cirucci, John
  • Lackner, Klaus

Abstract

A system for collecting a sorbate gas from a sorbent is disclosed, including a regeneration vessel enclosing a sorbent having a sorbate gas, a liquid water supply heated to a first temperature, and a heat pump with a condenser. The heat pump is also in contact with the water supply. Heat is removed from the condenser and used to heat the water supply to the first temperature. The system includes a compressor coupled to the condenser. The sorbent within the vessel is placed in contact with water vapor at the first temperature. The water vapor coming into contact with the sorbent causes sorbate gas to be released, forming a mixture including sorbate and water gases, raising the pressure. The vapor mixture is removed and cooled by the condenser, where a portion is condensed into water that is returned to the supply. The remaining mixture is compressed into a product gas.

IPC Classes  ?

  • B01D 53/047 - Pressure swing adsorption
  • B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

79.

WASTEWATER TREATMENT SYSTEMS AND METHODS

      
Application Number 18255857
Status Pending
Filing Date 2021-12-03
First Publication Date 2024-01-25
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
Inventor
  • Boltz, Joshua
  • Rittmann, Bruce
  • Daigger, Glen

Abstract

A biofilm membrane bioreactor system with a bioreactor, at least two membrane plates positioned within the bioreactor, and a plurality of biofilm carriers suspended within the wastewater in the bioreactor. The bioreactor has at least one inlet and at least one outlet. The at least two membrane plates are configured to filter the wastewater to generate permeate and may be formed of a ceramic material. Each of the at least two membrane plates are separated from adjacent membrane plates by a membrane gap that is at least two times larger than a smallest dimension of one of the biofilm carriers.

IPC Classes  ?

80.

ANTIBODIES SPECIFIC FOR QSOX1 AND METHODS OF USING THE SAME

      
Application Number 18257444
Status Pending
Filing Date 2021-12-15
First Publication Date 2024-01-25
Owner
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
  • MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventor
  • Lake, Douglas
  • Ho, Thai
  • Koelbel, Calvin

Abstract

Provided are antibodies specific for human QSOX1 and methods of using these antibodies or antigen binding regions thereof in assays to detect QSOX1, to inhibit QSOX1, for use in other assay systems, and for use in treating cancer.

IPC Classes  ?

  • C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
  • A61P 35/00 - Antineoplastic agents
  • G01N 33/573 - Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

81.

METAL-ASSISTED DELAYED FLUORESCENT MATERIALS AS CO-HOST MATERIALS FOR FLUORESCENT OLEDS

      
Application Number 18473609
Status Pending
Filing Date 2023-09-25
First Publication Date 2024-01-25
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor Li, Jian

Abstract

A light emitting device includes a first electrode, a hole transporting layer in contact with the first electrode, a second electrode, an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a metal-assisted delayed fluorescent (MADF) emitter, a fluorescent emitter, and a host, and the MADF emitter harvests electrogenerated excitons and transfers energy to the fluorescent emitter.

IPC Classes  ?

  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
  • H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
  • H10K 50/13 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers specially adapted for multicolour light emission, e.g. for emitting white light comprising stacked EL layers within one EL unit
  • H10K 85/60 - Organic compounds having low molecular weight
  • H10K 85/30 - Coordination compounds

82.

METHODS AND RELATED ASPECTS FOR DETERMINING BINDING KINETICS OF LIGANDS

      
Application Number 18349650
Status Pending
Filing Date 2023-07-10
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Wang, Shaopeng
  • Ma, Guangzhong
  • Zhou, Xiaoyan

Abstract

Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of receptors connected to the first surface via one or more linker moieties, wherein the receptors bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the receptors to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the receptors over a duration. Related receptor oscillator array devices, systems and computer readable media are also provided.

IPC Classes  ?

  • G01N 33/557 - Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 21/552 - Attenuated total reflection

83.

MECHANOPHORE-GRAFTED POLYMERS TO FORM STRESS-RESPONSIVE THERMOSET NETWORK

      
Application Number 18356526
Status Pending
Filing Date 2023-07-21
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Dai, Lenore
  • Chattopadhyay, Aditi
  • Nofen, Elizabeth
  • Zou, Jin
  • Koo, Bonsung

Abstract

Compositions including a thermosetting polymer network and a mechanophore covalently bonded to the thermosetting polymer network are provided. Substrates including the compositions are provided. In addition, methods of making the compositions and methods of monitoring stress on a substrate comprising the compositions are provided.

IPC Classes  ?

  • C08G 59/14 - Polycondensates modified by chemical after-treatment
  • C08G 59/50 - Amines
  • C08K 5/20 - Carboxylic acid amides
  • C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
  • G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

84.

SYSTEM AND METHOD FOR EFFICIENT CARBON DIOXIDE CAPTURE

      
Application Number 18255078
Status Pending
Filing Date 2021-12-08
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Cirucci, John
  • Lackner, Klaus

Abstract

A system and method for the efficient collection of CO2 is disclosed. The system includes a subsystem having a condenser and a vaporizer, and a plurality of vessels each having a sorbent and configured to transition between gas collection, gas recovery, and heat recovery phases. The gas collection phase includes the sorbent absorbing CO2. The gas recovery phase has N stages, the vessels releasing a product gas and receiving vapor causing captured CO2 to desorb. The first (N−1) gas recovery stages include the vessel coupled to the subsystem at a downstream pressure and a vessel in the heat recovery phase at an upstream pressure. The Nth gas recovery stage includes the vessel coupled to the condenser at the downstream pressure and the vaporizer at the upstream pressure. The heat recovery phase has (N−1) stages, each including the vessel being coupled to a vessel in the gas recovery phase.

IPC Classes  ?

  • B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

85.

DEVICE, SYSTEM, AND METHOD FOR CARBON DIOXIDE CAPTURE IN HUMID CONDITIONS

      
Application Number 18255082
Status Pending
Filing Date 2021-12-08
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Cirucci, John
  • Lackner, Klaus

Abstract

A device, method, and system for CO2 capture is disclosed. The method includes receiving a process vapor including water and CO2 into a vessel at an intake pressure, the vessel having a desiccant and a CO2 sorbent material. The method includes passing the process vapor through the desiccant and sorbent, the desiccant absorbing the water resulting in a dry vapor, the sorbent absorbing CO2 from the dry vapor resulting in a CO2-lean dry vapor. The method includes discontinuing the process vapor, desorbing the water from the desiccant by at least one of reducing pressure downstream from the desiccant to below the intake pressure and increasing a temperature of the desiccant, desorbing the CO2 from the sorbent by placing the desorbed water in contact with the sorbent, removing the desorbed CO2 through the product outlet as a product stream, and desorbing a remaining water from the desiccant and the sorbent.

IPC Classes  ?

  • B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
  • B01D 53/26 - Drying gases or vapours

86.

NANOTWINNED NICKEL FILMS WITH HIGH STRENGTH AND DUCTILITY

      
Application Number 18350138
Status Pending
Filing Date 2023-07-11
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Rajagopalan, Jagannathan
  • Berlia, Rohit

Abstract

Synthesis of high SFE nanotwinned metallic films with varying distributions of twin widths on a low SFE metallic layer using magnetron sputtering is disclosed. In various embodiments, a method for forming a nanotwinned metal film may include providing a single crystal silicon wafer, etching the single crystal silicon wafer, depositing a silver film onto the single crystal silicon wafer forming a silver buffer layer, and depositing a metallic film onto the silver buffer layer using sputtering at a controlled temperature.

IPC Classes  ?

  • C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
  • C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
  • C23C 14/02 - Pretreatment of the material to be coated
  • C23C 14/54 - Controlling or regulating the coating process

87.

Loop-Mediated Synthetic Riboregulators

      
Application Number 18465077
Status Pending
Filing Date 2023-09-11
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Green, Alexander
  • Ma, Duo

Abstract

Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6816 - Hybridisation assays characterised by the detection means

88.

SYSTEMS AND METHODS FOR A CROSS MEDIA JOINT FRIEND AND ITEM RECOMMENDATION FRAMEWORK

      
Application Number 18114125
Status Pending
Filing Date 2023-02-24
First Publication Date 2024-01-18
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Shu, Kai
  • Wang, Suhang
  • Tang, Jiliang
  • Wang, Yilin
  • Liu, Huan

Abstract

Various embodiments of systems and methods for cross media joint friend and item recommendations are disclosed herein.

IPC Classes  ?

  • G06Q 30/0282 - Rating or review of business operators or products
  • G06Q 50/00 - Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
  • G06N 5/022 - Knowledge engineering; Knowledge acquisition
  • G06N 5/04 - Inference or reasoning models
  • G06F 18/2136 - Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods based on sparsity criteria, e.g. with an overcomplete basis

89.

METHODS FOR USE OF SOFT CONTINUUM ROBOTIC MODULE

      
Application Number 18174273
Status Pending
Filing Date 2023-02-24
First Publication Date 2024-01-18
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Zhang, Wenlong
  • Nguyen, Pham Huy
  • Qiao, Zhi
  • Seidel, Sam
  • Mohd, Imran I.B.
  • Amatya, Sunny

Abstract

A soft continuum robotic module comprises a plurality of inflatable actuators disposed between plates. Via inflation or deflation of one or more of the actuators, the module may extend, contract, twist, bend, and/or exert a grasping force. One or more modules may be combined to form a robotic arm with multiple degrees of freedom.

IPC Classes  ?

  • B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
  • B25J 18/06 - Arms flexible
  • B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
  • B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

90.

RECONFIGURABLE DNA NANO-TWEEZER

      
Application Number 18327434
Status Pending
Filing Date 2023-06-01
First Publication Date 2024-01-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Stephanopoulos, Nicholas
  • Liu, Minghui

Abstract

A photocaged DNA nano-tweezer and methods of using said photocaged DNA nano-tweezer are described. In particular, provided herein is a DNA nano-tweezer comprising a hairpin with a single-stranded loop that comprises a first arm and a second arm; and a trigger strand complementary to the single-stranded loop and comprising at least one photocaged residue with a protecting group.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof

91.

COUPLING LASER CAPTURE MICRODISSECTION WITH MICROFLUIDIC SAMPLE PREPARATION AND MASS SPECTROMETRY

      
Application Number 18335713
Status Pending
Filing Date 2023-06-15
First Publication Date 2024-01-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Ros, Alexandra
  • Cruz Villarreal, Jorvani
  • Egatz-Gomez, Ana
  • Sandrin, Todd
  • Coleman, Paul

Abstract

Described herein are systems and methods for a microfluidic immunoassay for in situ mass spectrometry analysis of intracellular protein biomarkers in tissue. In some embodiments, the tissue may comprise human brain tissue. In some embodiments, the protein biomarkers may comprise Aβ species comprising monomers and oligomers of Aβ1-42, Aβ1-40, Aβ1-39, Aβ2-43, or combinations thereof. In some embodiments, the systems and methods may comprise laser capture microdissection (LCM) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

92.

DEPOLYMERIZATION OF RECOVERED PLASTIC MATERIALS

      
Application Number 18468567
Status Pending
Filing Date 2023-09-15
First Publication Date 2024-01-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Deng, Shuguang
  • Liu, Yixin
  • Akula, Kapil Chandra
  • Dandamudi, Kodanda Phani Raj

Abstract

Described herein are systems and methods for the depolymerization of polyethylene-based plastics. In one embodiment, a method is disclosed that comprises combining a polyethylene-based plastic with a solvent in a reactor to generate a plastic solvent mixture, heating the plastic solvent mixture in the reactor, and fractionating the plastic solvent mixture into a gas phase product, a solid phase product, and a liquid phase product. In another embodiment, a system is disclosed that comprises a solvent, and a reactor configured to receive the polyethylene-based plastic and the solvent and convert the polyethylene-based plastic into a gas phase product, a solid phase product, and a liquid phase product, the reactor being configured to operate at a temperature greater than 275° C. and at a pressure greater than 2 megapascals.

IPC Classes  ?

  • C10G 1/10 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal from rubber or rubber waste
  • C10G 1/00 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal
  • B01J 6/00 - Calcining; Fusing
  • B01D 3/14 - Fractional distillation
  • B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
  • C08J 11/08 - Recovery or working-up of waste materials of polymers without chemical reactions using selective solvents for polymer components

93.

NUCLEIC ACID-TAGGED COMPOSITIONS AND METHODS FOR MULTIPLEXED PROTEIN-PROTEIN INTERACTION PROFILING

      
Application Number 18348201
Status Pending
Filing Date 2023-07-06
First Publication Date 2024-01-11
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor Labaer, Joshua

Abstract

Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

94.

GREEN AND RED ORGANIC LIGHT-EMITTING DIODES EMPLOYING EXCIMER EMITTERS

      
Application Number 18467348
Status Pending
Filing Date 2023-09-14
First Publication Date 2024-01-11
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Li, Jian
  • Wu, Jiang

Abstract

Organic light emitting devices (OLEDs) are described, the OLEDs comprising an anode; a cathode; and an organic region, disposed between the anode and the cathode, comprising a first complex and a second complex; wherein when a voltage is applied across the anode and cathode at room temperature, the OLED emits a luminescent radiation that comprises one or more luminescent radiation components resulting from the formation of at least one exciplex; wherein the exciplex is formed by at least one of the following aggregate types: 1) at least one aggregate within the first complex, and at least one aggregate within the second complex; 2) at least one aggregate between the first and the second complex; and 3) both 1 and 2.

IPC Classes  ?

  • H10K 85/30 - Coordination compounds
  • C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

95.

A UNIVERSAL PLATFORM TO ENHANCE CRISPR-BASED GENE EDITING FOR IN VIVO THERAPIES

      
Application Number 18327373
Status Pending
Filing Date 2023-06-01
First Publication Date 2024-01-04
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Kiani, Samira
  • Ebrahimkhani, Mo Reza
  • Chapman, Jennifer

Abstract

Aspects of the disclosure relate to methods and synthetic regulatory systems for more efficient nuclease-mediated homology-directed repair (HDR). In particular, provided herein are methods for more efficient in vivo and in vitro HDR-based gene editing where the methods comprise introducing into a cell a synthetic regulatory system comprising Cas nuclease, guide RNAs (gRNAs) having various lengths and configured to target distinct nucleotide sequences for simultaneous transcriptional repression (or activation) and genome editing via double stranded break and use of a donor nucleic acid molecule as a template for repair.

IPC Classes  ?

  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12N 15/62 - DNA sequences coding for fusion proteins

96.

ENCAPSULANT-CONTAINING POLYMER CAPSULES AND FIBERS AND COMPOSITES INCLUDING SAME

      
Application Number 18039322
Status Pending
Filing Date 2022-01-20
First Publication Date 2024-01-04
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Green, Matthew
  • Korah, Mani Modayil

Abstract

Systems and methods for preparing encapsulant-containing polymer capsules and fibers, as well as the encapsulant-containing polymer capsules and fibers and composites including the same are described. In one example, forming a plurality of encapsulant-containing polymer capsules includes preparing a mixture comprising a polymer, a solvent, an encapsulant, and a polymer that is soluble in the solvent, and removing some of the solvent from the mixture to yield the plurality of polymer capsules. Each polymer capsule include a shell formed of the polymer and contains the encapsulant. In another example, forming a plurality of polymer fibers containing an encapsulant includes providing the mixture to an electrospin apparatus and electrospinning the mixture to yield the plurality polymer fibers, where each polymer fiber defines a hollow core that contains the encapsulant.

IPC Classes  ?

  • D01D 5/00 - Formation of filaments, threads, or the like
  • B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
  • B01J 13/12 - Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
  • D01D 1/02 - Preparation of spinning solutions
  • D01D 5/24 - Formation of filaments, threads, or the like with a hollow structure; Spinnerette packs therefor

97.

SYSTEMS AND METHODS FOR A SPRING-AUGMENTED QUADROTOR FOR INTERACTIONS WITH CONSTRAINED ENVIRONMENTS

      
Application Number 18241654
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-01-04
Owner Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
  • Zhang, Wenlong
  • Rezayat Sorkhabadi, Seyed Mostafa
  • Mishra, Shatadal
  • Patnaik, Karishma

Abstract

Various embodiments of a variable geometry quadrotor with a compliant frame are disclosed, which adapts to tight spaces and obstacles by way of passive rotation of its arms.

IPC Classes  ?

  • B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters

98.

METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MODULATING TEMPERATURE AND PRODUCING ANALYTE IMAGING DATA

      
Application Number 18212460
Status Pending
Filing Date 2023-06-21
First Publication Date 2024-01-04
Owner ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
Inventor
  • Wang, Shaopeng
  • Wang, Rui
  • Zhang, Pengfei

Abstract

Provided herein are methods of modulating temperature in detection fields and producing analyte imaging data. In some embodiments, the methods include introducing an incident light toward a second surface of a substrate to induce a plasmonic wave proximal to a first surface of the substrate such that a temperature in a selected heating space within the detection field is substantially uniformly changed to a selected temperature. Additional methods as well as related systems and computer readable media are also provided.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

99.

USER-SPACE EMULATION FRAMEWORK FOR HETEROGENEOUS SOC DESIGN

      
Application Number 18249885
Status Pending
Filing Date 2021-10-22
First Publication Date 2024-01-04
Owner
  • Arizona Board of Regents on Behalf of Arizona State University (USA)
  • Arizona Board of Regents on Behalf of the University of Arizona (USA)
  • Board of Regents, The University of Texas System (USA)
  • Carnegie Mellon University (USA)
Inventor
  • Ogras, Umit
  • Marculescu, Radu
  • Akoglu, Ali
  • Chakrabarti, Chaitali
  • Bliss, Daniel
  • Arda, Samet Egemen
  • Sartor, Anderson
  • Kumbhare, Nirmal
  • Krishnakumar, Anish
  • Mack, Joshua
  • Goksoy, Ahmet
  • Mandal, Sumit

Abstract

A user-space emulation framework for heterogeneous system-on-chip (SoC) design is provided. Embodiments described herein propose a portable, Linux-based emulation framework to provide an ecosystem for hardware-software co-design of heterogenous SoCs (e.g., domain-specific SoCs (DSSoCs)) and enable their rapid evaluation during the pre-silicon design phase. This framework holistically targets three key challenges of heterogeneous SoC design: accelerator integration, resource management, and application development. These challenges are addressed via a flexible and lightweight user-space runtime environment that enables easy integration of new accelerators, scheduling heuristics, and user applications, and the utility of each is illustrated through various case studies. A prototype compilation toolchain is introduced that enables automatic mapping of unlabeled C code to heterogeneous SoC platforms. Taken together, this environment offers a unique ecosystem to rapidly perform functional verification and obtain performance and utilization estimates that help accelerate convergence towards a final heterogeneous SoC design.

IPC Classes  ?

  • G06F 11/34 - Recording or statistical evaluation of computer activity, e.g. of down time, of input/output operation
  • G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
  • G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

100.

SYSTEMS FOR REMOVING EXPLOSIVES AND OTHER COEXISTING CONTAMINANTS FROM WATER AND RELATED METHODS

      
Application Number 18253192
Status Pending
Filing Date 2021-11-17
First Publication Date 2024-01-04
Owner Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
  • Rittmann, Bruce
  • Zhou, Chen
  • Zheng, Chenwei

Abstract

The present invention relates to systems and methods for removing oxidized contaminants from water and wastewater using a metal-biofilm, also referred to herein as a bio-metal composite catalyst. In some embodiments, the system comprises a gas-transfer membrane, a hydrogen-gas source, an inoculant comprising a biofilm-forming population of microorganisms, a growth medium comprising at least one nitrate salt and at least one perchlorate salt, and a catalyst precursor medium comprising at least one soluble autocatalytic metal precursor and having a basic pH. Methods of establishing a bio-metal composite catalyst for removing ammunition-related contaminants are also described.

IPC Classes  ?

  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
  • B01D 69/08 - Hollow fibre membranes
  • C02F 3/10 - Packings; Fillings; Grids
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