Abstract

An intuitive framework for assembling instructional modules for educational purposes provides integrated programmatic logic to provide learners with agency and increase achievement. The framework enables educators to use content from a learning content database and assemble the content into adaptive learning pathways using a visual drag-and-drop approach combined with the creation of rules to drive adaptivity without requiring programming or coding skills.

IPC Classes  ?

• G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip

Abstract

Biochar can be used as an additive for bitumen. A bitumen composite includes bitumen and biochar. The biochar can include biochar from one or more of algae, food waste, animal waste, and cellulose-containing material (e.g., palm sheath). The biochar typically comprises 1 wt % to 20 wt % of the weight of the bitumen composite. The bitumen composite can be combined with aggregate to yield asphalt.

IPC Classes  ?

• C08K 11/00 - Use of ingredients of unknown constitution, e.g. undefined reaction products
• C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch

Abstract

A compact, low-power, high image rejection sideband separation receiver is provided. The receiver observes an input radio frequency (RF) signal of multiple spectral lines (spectral observation), then downconverts the signals to intermediate frequency (IF), and then separates the signals to be observed simultaneously in multiple channels. An embodiment is used to observe a signal (G-band) with two spectral lines and utilizes a two stage Weaver architecture to downconvert the signal's frequency, including a combination of mixers in the second stage that achieves the separation of two different channels.

IPC Classes  ?

• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

Abstract

Described herein are means for performing self-supervised visual representation learning using order and appearance recovery on a vision transformer. An exemplary system having a processor and memory is specially configured to execute instructions including: receiving medical image training data; selecting a medical image; generating a first perturbed image by applying local pixel shuffling and other image perturbations and outputting a first patchified perturbed image; generating a second randomized patchified image by patchifying and applying a random permutation to the original image; inputting the first patchified perturbed image and the second randomized patchified image into first and second transformer encoders which each generate and then share first and second generated weights through the recovery of both and patch order appearance from each image; and outputting a pre-trained AI model to perform medical image diagnosis on a new medical image absent from the training data input received by the system.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06T 7/00 - Image analysis
• G06T 5/10 - Image enhancement or restoration by non-spatial domain filtering
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Described herein are systems, methods, and apparatuses for implementing self-supervised domain-adaptive pre-training via a transformer for use with medical image classification in the context of medical image analysis. An exemplary system includes means for receiving a first set of training data having non-medical photographic images; receiving a second set of training data with medical images; pre-training an AI model on the first set of training data with the non-medical photographic images; performing domain-adaptive pre-training of the AI model via self-supervised learning operations using the second set of training data having the medical images; generating a trained domain-adapted AI model by fine-tuning the AI model against the targeted medical diagnosis task using the second set of training data having the medical images; outputting the trained domain-adapted AI model; and executing the trained domain-adapted AI model to generate a predicted medical diagnosis from an input image not present within the training data.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06V 10/776 - Validation; Performance evaluation
• G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06N 3/0895 - Weakly supervised learning, e.g. semi-supervised or self-supervised learning

Abstract

A communications network system is disclosed. The system may include a central processing unit (CPU) in data communication with a first access point (AP) configured to enable a data communication between the CPU and a first user equipment (UE). The CPU may include a processor configured to select a first group of APs including the first AP, establish a first data communications link over a first frequency band between the CPU- and the first AP, cause the first AP to establish a second data communications link over a second frequency band between the first AP and the first UE, and transmit a portion of data to the first AP over the first data communications link. The first data communications link may be a wireless data communications link. The first frequency band may include higher frequency levels than those of the second frequency band.

IPC Classes  ?

• H04B 7/0452 - Multi-user MIMO systems

Abstract

The invention provides compounds having the general formula I: The invention provides compounds having the general formula I: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

IPC Classes  ?

• C07D 279/18 - [b, e]-condensed with two six-membered rings
• A61P 39/06 - Free radical scavengers or antioxidants
• A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• C07D 279/14 - 1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents

Abstract

Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of virions connected to the first surface via one or more linker moieties, wherein viral envelopes of the virions display one or more proteins that bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the virions to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the virions over a duration. Related virion oscillator array devices, systems and computer readable media are also provided.

IPC Classes  ?

• G01N 33/94 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

ElectroCorticoGraphy (ECoG) sensors and uses are disclosed. These ECoG arrays, systems, and processes may be operable or configured to: i) simultaneously record neural signals while providing stimulation on specific portions of the cortex using a user-guided stimulator; ii) acquire neural signals over a large cortex area; iii) provide individual or group stimulation while concurrently receiving neural feedback; and/or iv) acquire neural signals at a setting remote from the neural source using wireless or other communication techniques.

IPC Classes  ?

• A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

A system reconfigures a photovoltaic array used in solar energy based on observed shading conditions to determine an optimal topology of the photovoltaic array to maximize power output. Specifically, the system is designed to reconfigure a photovoltaic array when the photovoltaic array is partially shaded. The system uses a neural network model to determine a topology that maximizes power output of the photovoltaic array based on irradiance data obtained from the photovoltaic array.

IPC Classes  ?

• H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
• G05F 1/67 - Regulating electric power to the maximum power available from a generator, e.g. from solar cell

Abstract

Provided herein are methods of determining molecular binding kinetics on particles, such as magnetic nanoparticles. In some embodiments, the methods include introducing an incident light from a light source toward a sample container that comprises a particle-bound biomolecule-ligand composition comprising a plurality of particle-bound biomolecules and a plurality of ligands that binds, or is capable of binding, to biomolecules of the plurality of particle-bound biomolecules, detecting light scattered from particle-bound biomolecule-ligand complexes in the particle-bound biomolecule-ligand composition over a duration to produce a set of imaging data using the detector, and determining size or volume changes of one or more of the particle-bound biomolecule-ligand complexes during at least a portion of the duration from the set of imaging data to thereby determine the molecular binding kinetics on the particles. Related systems and computer readable media are also provided.

IPC Classes  ?

• G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Abstract

The present disclosure provides compositions and methods related to nucleic acid sensors. In particular, the present disclosure provides membrane-spanning nucleic acid sensors, signal transducers, and molecular amplifiers for lysis-free detection of internal nucleic acids.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

Disclosed herein are methods of treating a lung disorder. In some embodiments, the lung disorder includes an acute respiratory syndrome. In some embodiments, the treatment includes administering to a subject in need thereof, a modified Serp-1 protein. The modified Serp-1 protein may include a therapeutic enhancing moiety. In some embodiments, the therapeutic enhancing moiety is a water soluble polymer such as polyethylene glycol.

IPC Classes  ?

• C07K 14/81 - Protease inhibitors
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A skylight for a building includes a solar panel arranged within the skylight, the solar panel comprising one or more photovoltaic cells to collect direct radiation from rays of sunlight for conversion to electrical power, and an optical element to receive the direct radiation and refract it to the solar panel, and to receive the direct radiation and diffuse radiation scattered from the rays of sunlight and refract the direct radiation and the diffuse radiation through the skylight, bypassing the solar panel, to provide daylighting in the building.

IPC Classes  ?

• E04D 13/03 - Sky-lights; Domes; Ventilating sky-lights
• F21S 11/00 - Non-electric lighting devices or systems using daylight
• G02B 5/32 - Holograms used as optical elements
• G02B 5/20 - Filters
• H02S 40/22 - Light-reflecting or light-concentrating means
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshine; Similar screens for privacy or appearance
• H02S 20/26 - Building materials integrated with PV modules, e.g. façade elements

Abstract

Wound healing is a process by which these wounds on the skin of a subject heal and eventually close. When the injured surface is large, becomes infected, or in patients with poor healing capacity such as diabetics or the elderly or bedridden patients, then wound healing can be prolonged and lead to chronic ulceration and further complications with even limb loss or increased morbidity and mortality. This invention is directed to a topical formulation for promoting wound healing, and wound dressings and bandages comprising the same.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• A61K 38/16 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Abstract

Described herein is a process in which filamentous fungi can be used to create textile or paper materials with tunable properties. The textiles can range from leather-like to paper-like depending on the species of fungi used and the growth conditions. The method of production utilizes the tendency of filamentous fungi to form films on still liquids, in order to generate many mycelial mats concurrently. These mats can then be layered to create textile materials, paper materials, and other material types having varying thickness, composition, and mechanical properties.

IPC Classes  ?

• A01G 18/00 - Cultivation of mushrooms
• D21C 3/00 - Pulping cellulose-containing materials

Abstract

A Discriminative, Restorative, and Adversarial (DiRA) learning framework for self-supervised medical image analysis is described. For instance, a pre-trained DiRA framework may be applied to diagnosis and detection of new medical images which form no part of the training data. The exemplary DiRA framework includes means for receiving training data having medical images therein and applying discriminative learning, restorative learning, and adversarial learning via the DiRA framework by cropping patches from the medical images; inputting the cropped patches to the discriminative and restorative learning branches to generate discriminative latent features and synthesized images from each; and applying adversarial learning by executing an adversarial discriminator to perform a min-max function for distinguishing the synthesized restorative image from real medical images. The pre-trained model of the DiRA framework is then provided as output for use in generating predictions of disease within medical images.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 5/00 - Image enhancement or restoration
• G06V 10/74 - Image or video pattern matching; Proximity measures in feature spaces
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A composite wire material may comprise a core wire comprising copper (Cu). The core wire material may comprise a first layer on a circumferential surface of the core wire, where the first layer comprises graphene. The composite wire material may comprise a second layer on a circumferential surface of the first layer, where the second layer comprises nickel (Ni).

IPC Classes  ?

• H01B 1/02 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of metals or alloys
• H01B 1/04 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of carbon-silicon compounds, carbon, or silicon
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Disclosed herein is a system and method for quantitative detection and analysis of molecular binding kinetics of a substance with surface membrane proteins of a biological object, such as a live cell, based on detecting and tracking membrane fluctuation amplitude changes cause by membrane displacement associated with the binding of the substance with the surface membrane proteins. The molecular binding kinetics can be detected with high precision in real time from an optical image of the biological object with a differential detection method.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G06V 10/14 - Optical characteristics of the device performing the acquisition or on the illumination arrangements
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
• G06V 10/62 - Extraction of image or video features relating to a temporal dimension, e.g. time-based feature extraction; Pattern tracking

Abstract

A carbon dioxide collection system having a release enclosure, a capture structure, and a chimney is disclosed. The release enclosure includes a sorbent regeneration system. The capture structure includes a sorbent material, and is movable between collection and release configurations. The chimney is shaped such that an airflow upward through the chimney is created. The chimney is positioned above the release enclosure such that the airflow passes through the capture structure while in the collection configuration. The collection configuration includes the capture structure being elevated above the release enclosure so the sorbent material is exposed to the airflow generated by the chimney, allowing the sorbent material to capture CO2 from the airflow. The release configuration includes the capture structure being sufficiently enclosed inside the release enclosure that the sorbent regeneration system may operate on the sorbent material to release CO2 collected by the capture structure to form an enriched fluid.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• F24S 70/60 - SOLAR HEAT COLLECTORS; SOLAR HEAT SYSTEMS - Details of absorbing elements characterised by the structure or construction

Abstract

Described are platforms, systems, media, and methods for evaluating, monitoring, and/or treating a subject for brain injury based on machine learning analysis of one or more of brain imaging features, clinical features, demographic features, or speech features.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G10L 25/66 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for extracting parameters related to health condition
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G06N 20/00 - Machine learning

Abstract

Embodiments of a lightweight unobtrusive wearable device which is operable to continually monitor an instantaneous hand pose are disclosed. In some embodiments, the device measures the position of the wrist relative to one's body and the configuration of the hand. The device may infer hand pose in real-time and, as such, can be combined with actuators or displays to provide instantaneous feedback to the user. The device may be worn on the wrist and all processing can be performed within the device, thus addressing privacy.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/0346 - Pointing devices displaced or positioned by the user; Accessories therefor with detection of the device orientation or free movement in a 3D space, e.g. 3D mice, 6-DOF [six degrees of freedom] pointers using gyroscopes, accelerometers or tilt-sensors
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition

Abstract

An active shoulder rest, comprising: at least one sound diffusion speaker; at least one actuator; and at least one amplifier, wherein the at least one sound diffusion speaker and the at least one actuator are connected to the at least one amplifier. The active shoulder rest may further comprise a body, and a damping material within the body. The active shoulder rest may further comprise at least one port configured for a microphone pickup.

IPC Classes  ?

• G10D 3/18 - Chin-rests, hand-rests, shoulder rests or guards being removable from, or integral with the instrument
• G10G 5/00 - Supports for musical instruments
• G10H 3/18 - Instruments in which the tones are generated by electromechanical means using mechanical resonant generators, e.g. strings or percussion instruments, the tones of which are picked up by electromechanical transducers, the electrical signals being further manipulated or amplified and subsequently converted to sound by a lo using mechanically actuated vibrators with pick-up means using strings, e.g. electric guitars

Abstract

A device and method for measuring excreted ketones in a body fluid. The device includes a housing and a sensor positioned within the housing. The sensor includes a body, and a cavity formed in the body, the cavity configured to hold a colorimetric sensing liquid, the body including a ketone permeable medium and a hydrophobic membrane with or without an alkaline material to prevent acidic gases or volatile compound interferents. The sensor is configured to detect presence of ketone in the body fluid in contact with the housing.

IPC Classes  ?

• G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands

Abstract

The present disclosure describes examples of a computer-implemented framework that helps to detect deception in charts and/or associated articles through textual and visual annotations.

IPC Classes  ?

• G06F 40/169 - Annotation, e.g. comment data or footnotes
• G06V 30/14 - Image acquisition
• G06V 30/19 - Recognition using electronic means
• G06F 40/30 - Semantic analysis

Abstract

A radar stethoscope system (12) and method for respiration and heart sound assessment is provided. Embodiments present a method to measure acoustics related to breathing and heartbeat sounds using small-scale radars. Acoustic data derived from the radar return measurements can be based on phase changes of the radar return measurements over a period of time. The radar stethoscope (12) can capture and identify respiratory and heart acoustics as traditionally captured by a clinical stethoscope. Using advanced radar processing algorithms, these acoustic signals can be recovered from a distance and without making contact with the patient (14).

IPC Classes  ?

• A61B 7/04 - Electric stethoscopes
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/113 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
• G01S 13/02 - Systems using reflection of radio waves, e.g. primary radar systems; Analogous systems

Abstract

Devices, and methods for preventing immune rejections are disclosed, in which trophoblasts or trophoblast-like cells are used to induce tolerance toward allogeneic cell and tissue grafts. The devices can be used as artificial placenta vaccines to avoid immunosuppression in organ transplantation.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C12N 5/073 - Embryonic cells or tissues; Foetal cells or tissues
• A61K 35/54 - Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells

Abstract

An artificial turf system may comprise a plurality of synthetic filaments and a substrate base layer coupled to the plurality of synthetic filaments. Each filament of the plurality of synthetic filaments may comprise a pigment having an elevated solar reflectance for wavelengths less than 2500 nm. This elevated solar reflectance may be configured to reflect near-infrared radiation, thereby reducing near-surface air temperatures and the artificial turf surface temperatures. Such engineered pigments may also be advantageously used in the leaves of artificial vegetation systems, such as, for example, artificial shrubs and trees.

IPC Classes  ?

• E01C 13/08 - Surfaces simulating grass
• D01F 1/04 - Pigments
• D06N 7/00 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material

Abstract

Various embodiments of a system and associated method for a smart handoff integrated platform for handoff of items to customers in the retail space are disclosed herein.

IPC Classes  ?

• G06Q 10/0833 - Tracking
• G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
• G06T 7/20 - Analysis of motion
• G06T 7/70 - Determining position or orientation of objects or cameras

Abstract

In accordance with embodiments disclosed herein, there are provided herein systems and methods for implementing aggregable, environment-controlled mini-containers for the efficient logistics of perishable products. For example, there is a system for providing efficient transportation logistics of dissimilar perishable products within a transportation unit, in which the system includes: multiple mini-containers, each being configurable to stack and aggregate to consume at least a portion of volume within the transportation unit; a Central Driving Unit (CDU) operable to provide services to each of the mini-containers to maintain the contents of each mini-container; a Central Control Unit (CCU) to receive sensor information from each of the mini-containers and further to issue control parameters for maintaining a specified atmosphere composition within each connected mini-container via the CDU, in which the CCU executes the control parameters for maintaining the specified atmosphere composition within each connected mini-container by activating actuators, in which the actuators manipulate valves at each mini-container, allowing for inflow and egress of atmospheric elements; and in which each of the multiple mini-containers constitute individual modular units configurable to form a single inter-connected and aggregated stack having a size which fits within the available volume of the transportation unit. In related embodiments, the CCU is further configured to transmit data on the status of the mini-containers to the outside world, such as transmitting status information to a remote storage location, or to the cloud, or directly to a centrally located data hub. Other related embodiments are disclosed.

IPC Classes  ?

• G06Q 10/0832 - Special goods or special handling procedures, e.g. handling of hazardous or fragile goods

Abstract

Disclosed are compositions comprising chimeric antigen receptors (CARs) and related methods of use in cancer immunotherapy. Compositions include reprogrammed immune cells (e.g., macrophages, neutrophils, dendritic cells, and T cells) that are metabolically fit for tumor microenvironments. The engineered immune cells are reprogrammed to express one or more of recombinant CARs at their cell surfaces and are loaded with glycolysis accelerating metabolites (e.g., F16BP or succinate). Methods of treating a subject with a condition, such as cancer, are also disclosed and include administering an effective amount of a composition comprising an engineered immune cell to a subject in need thereof.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61K 31/70 - Carbohydrates; Sugars; Derivatives thereof
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention is directed to systems and methods for removing trichloroethane (TCA), trichloroethene (TCE), and 1,4-dioxane (1,4-D) from contaminated water and wastewater. The system and methods relying on catalyst reduction of TCA and TCE, and the reduced products are degraded by microorganisms that are capable of biodegrading ethane and 1,4-D. In certain embodiments, a catalyst film comprises precious nanoparticles with diameters of 5-40 nm and a biofilm comprising microorganisms that are capable of degrading ethane and 1,4-D are used in a dual-reactor system to remove TCA, TCE, and 1,4-D from contaminated water and wastewater.

IPC Classes  ?

• C02F 1/70 - Treatment of water, waste water, or sewage by reduction
• C02F 3/10 - Packings; Fillings; Grids
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• B01J 23/44 - Palladium
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/02 - Solids

Abstract

An additive manufacturing print head includes a spinneret defining a first channel configured to receive a first feedstock and a second channel configured to receive a second feedstock. The spinneret is configured to provide a bilayer extrudate including a layer of the first feedstock in direct contact with a layer of the second feedstock. The print head further includes a minimizer configured to receive the bilayer extrudate from the spinneret and to reduce a flow area of bilayer extrudate transverse to a flow direction of the bilayer extrudate, and a multiplier configured to transform the bilayer extrudate from the minimizer to a multilayer extrudate. The multilayer extrudate includes alternating layers of the first feedstock and the second feedstock.

IPC Classes  ?

• B29C 64/209 - Heads; Nozzles
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
• B33Y 10/00 - Processes of additive manufacturing

Abstract

A system defining a visual sensing pipeline architecture flexibly allows application developers to dynamically adapt the spatial resolution and update rate of different “rhythmic pixel encoding regions” in a scene. The system ingests pixel streams with raster-scan pixel read-out patterns, but only encodes relevant pixels prior to storing them in memory. The system includes streaming hardware to decode the stored rhythmic pixel encoding region stream into traditional frame-based representations to feed into standard computer vision algorithms.

IPC Classes  ?

• H04N 19/132 - Sampling, masking or truncation of coding units, e.g. adaptive resampling, frame skipping, frame interpolation or high-frequency transform coefficient masking
• H04N 19/172 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being an image region, e.g. an object the region being a picture, frame or field
• H04N 19/182 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being a pixel
• H04N 19/423 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals - characterised by implementation details or hardware specially adapted for video compression or decompression, e.g. dedicated software implementation characterised by memory arrangements
• H04N 19/167 - Position within a video image, e.g. region of interest [ROI]
• H04N 19/33 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using hierarchical techniques, e.g. scalability in the spatial domain

Abstract

A computer-implemented system incorporates a time-varying view of exploitability in the form of Expected Exploitability (EE) to learn and continuously estimate the likelihood of functional software exploits being developed over time. The system characterizes the noise-generating process systematically affecting exploit prediction, and applies a domain-specific technique (e.g., Feature Forward Correction) to learn EE in the presence of label noise. The system also incorporates timeliness and predictive utility of various artifacts, including new and complementary features from proof-of-concepts, and includes scalable feature extractors. The system is validated on three case studies to investigate the practical utility of EE, showing that the system incorporating EE can qualitatively improve prioritization strategies based on exploitability.

IPC Classes  ?

• G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
• G06F 21/55 - Detecting local intrusion or implementing counter-measures

Abstract

A light emitting device includes a first electrode, a hole transporting layer in contact with the first electrode, a second electrode, an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a phosphorescent emitter, a fluorescent emitter, and a host, and the phosphorescent emitter harvests electrogenerated excitons and transfers energy to the fluorescent emitter.

IPC Classes  ?

• H10K 50/15 - Hole transporting layers
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 50/12 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising dopants
• H10K 50/16 - Electron transporting layers
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

The present invention provides antimicrobial nanoparticles or compositions thereof comprising at least one phytochemical or bioactive compound, at least one lipid, at least one surfactant, and at least one vitamin E. In some embodiments, the antimicrobial nanoparticles or compositions thereof further comprise at least one coating agent. In some embodiments, the antimicrobial nanoparticles or compositions thereof are an edible coating. In various aspects, the present invention relates to methods of reducing or inhibiting the activity or level of or preventing the growth of at least one microorganism on a surface of an element. In some aspects, the present invention relates to methods of increasing a shelf-life of food and/or maintaining and improving food nutrients and/or nutrition values. In other aspects, the present invention relates to methods of delivering at least one nutritional or bioactive agent for preventing and treating various disorders and diseases.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A23L 29/00 - Foods or foodstuffs containing additives; Preparation or treatment thereof
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 33/15 - Vitamins
• A61K 9/127 - Liposomes
• A61K 31/05 - Phenols
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• A61P 31/04 - Antibacterial agents

Abstract

Provided herein are methods of generating neuropsychological functioning scores from test subject data. The methods include receiving a set of images produced by a test subject in which at least a first of the images comprises a rendition of a target image produced by the test subject at a first time point, and in which at least a second of the images comprises a rendition of the target image produced by the test subject at a second time point that differs from the first time point to produce the test subject data. The methods further include passing the test subject data through a trained machine learning algorithm and outputting from the trained machine learning algorithm a neuropsychological functioning score indicated by the test subject data. Additional methods as well as related systems and computer readable media are also provided.

IPC Classes  ?

• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

E. coli was used as an efficient platform for recombinant synthesis of fusel lactates such as the green solvent ethyl lactate.

IPC Classes  ?

• C12N 1/20 - Bacteria; Culture media therefor
• C12P 7/62 - Carboxylic acid esters

Abstract

An assistive feedback device is described herein and includes an array of vibrotactile actuators and thermal units affixed on a flexible casing that can be worn around the forearm. The vibrotactile actuators are used for obstacle detection by using a customizable encoding format. The directional cues for navigation are provided using the thermal units in a customizable format.

IPC Classes  ?

• G08B 6/00 - Tactile signalling systems, e.g. personal calling systems

Abstract

Described herein is an assistive medical system that is designed for individuals who are impacted by Midline-Shift Syndrome. Its purpose is to help them reorient and maintain their midline position to improve posture, balance, and other cognitive functions. This is achieved through haptic-feedback mechanisms and visual cues that gently notify the user when their position has deviated from the midline orientation.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

Platinum, palladium, and gold complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having one of the following structures: Platinum, palladium, and gold complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having one of the following structures:

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C07F 9/70 - Organo-arsenic compounds
• C07F 1/12 - Gold compounds
• C07F 7/08 - Compounds having one or more C—Si linkages
• C07F 7/30 - Germanium compounds
• C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
• C07F 9/80 - Heterocyclic compounds

Abstract

Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G01N 21/65 - Raman scattering

Abstract

An unmanned aerial vehicle (UAV) for gas transport is disclosed. The UAV includes a fuselage enclosing a volume, and a gas reservoir enclosed within the fuselage, filling at least a majority of the volume. The gas reservoir is configured to receive and store a gas at a pressure no greater than 100 bar. The UAV also includes a propulsion system having at least one engine, each of the at least one engine coupled to a prop that is driven by the at least one engine using energy derived from the gas stored in the gas reservoir. The UAV also includes a control system communicatively coupled to the propulsion system and configured to operate the unmanned aerial vehicle to autonomously transport the gas. The UAV may have a footprint while on the ground, and the footprint of the UAV may be no larger than three standard parking spaces.

IPC Classes  ?

• B64C 39/02 - Aircraft not otherwise provided for characterised by special use
• G05D 1/10 - Simultaneous control of position or course in three dimensions
• B64C 11/46 - Arrangements of, or constructional features peculiar to, multiple propellers
• B64C 29/02 - Aircraft capable of landing or taking-off vertically, e.g. vertical take-off and landing [VTOL] aircraft having its flight directional axis vertical when grounded
• B64D 9/00 - Equipment for handling freight; Equipment for facilitating passenger embarkation or the like
• B64D 27/24 - Aircraft characterised by the type or position of power plant using steam, electricity, or spring force
• B64C 3/10 - Shape of wings

Abstract

Disclosed herein are methods and compositions comprising transmembrane nanosensors, and their use to identify, detect, label, and isolate cells. In some embodiments, the nanosensors may be used in conjunction with a hybridization chain reaction to amplify a signal, and to aid in the detection, identification, labeling or isolation of cells.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/682 - Signal amplification
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

Sulfur copolymerization includes combining elemental sulfur with modified bitumen to yield a mixture, blending the mixture, and curing the mixture to yield a copolymerized modified bitumen. The modified bitumen includes waste vegetable oil. Inverse vulcanization includes combining an unsaturated fatty acid and an alkaline earth metal (hydr)oxide to yield a mixture, combining elemental sulfur with the mixture, and processing the mixture to yield a sulfur copolymer.

IPC Classes  ?

• C10C 3/02 - Working-up pitch, asphalt, bitumen by chemical means
• C10C 3/10 - Melting
• C08K 3/06 - Sulfur
• C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch

Abstract

Systems and methods for determining varying phenomena in an environment. In an embodiment, an system includes a processor configured to receive a sequence of remote sensing data regarding an environment, wherein the environment comprises a target area where changes have occurred and a surrounding area where few or no changes have occurred; process the RS data to determine signals for the changes that have occurred in the target area and where no changes have occurred in the surrounding area, wherein the signals comprise reflected sunlight radiation or returned light or radiation of different wavelengths captured by the sensor; process the signals to determining environment data indicting varying phenomena in the environment, wherein the varying phenomena in the environment comprise changes in the physical characteristics of the target area and an amount of radiation captured by the RS data; and provide the environment data for display via a user device.

IPC Classes  ?

• G06V 20/10 - Terrestrial scenes
• H04N 23/11 - Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from different wavelengths for generating image signals from visible and infrared light wavelengths
• G06V 20/13 - Satellite images
• H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries
• G01C 13/00 - Surveying specially adapted to open water, e.g. sea, lake, river or canal

Abstract

A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes

Abstract

Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery

Abstract

A magnetic tunneling junction (MTJ) device structure and the method of constructing such device are disclosed. Also disclosed are methods of using the device for spin-dependent transport characterization through biomolecules for structure and dynamic function analysis in physiological environments.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/20 - Spin-polarised current-controlled devices

Abstract

Processing algae includes liquefying algae to yield a mixture including biocrude oil, biochar, and an aqueous component, and treating the biochar to yield a nutrient composition including ammoniacal nitrogen and phosphate.

IPC Classes  ?

• C01B 32/318 - Preparation characterised by the starting materials
• C01B 32/378 - Purification

Abstract

A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component.

IPC Classes  ?

• G01N 23/20025 - Sample holders or supports therefor
• G01N 23/201 - Measuring small-angle scattering, e.g. small angle X-ray scattering [SAXS]
• B01L 3/02 - Burettes; Pipettes
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Synthesizing upconverting nanoparticles includes heating a precursor solution comprising one or more rare earth salts, an alkali metal salt or alkaline earth salt, and a solvent comprising a plasticizer in a microwave reactor to yield a product mixture, and cooling the product mixture to yield the upconverting nanoparticles. Core-shell upconverting nanoparticles are synthesized by combining the upconverting nanoparticles with a precursor solution comprising one or more rare earth salts, an alkali metal salt or alkaline earth salt, and a solvent comprising a plasticizer to yield a nanoparticle mixture, heating the nanoparticle mixture in a microwave reactor to yield a product mixture, and cooling the product mixture to yield the core-shell upconverting nanoparticles.

IPC Classes  ?

• C01F 17/36 - Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6 halogen being the only anion, e.g. NaYF4
• B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
• B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C01F 17/265 - Fluorides
• C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals

Abstract

The present invention relates to a method for decreasing microbial biomass and biodegradation rates of in situ bioremediation system using acetylene as the inhibitor.

IPC Classes  ?

• F17C 11/00 - Use of gas-solvents or gas-sorbents in vessels
• C07C 11/24 - Acetylene
• F02B 43/12 - Methods of operating

Abstract

A lithium-ion battery separator includes a substrate defining inter-particle pores and a zeolite coating on a surface of the substrate. The zeolite coating includes zeolite particles. The zeolite particles are hydrophobic and have an average diameter smaller than an average pore size of inter-particle pores of the substrate, such that some of the zeolite particles are positioned in some of the inter-particle pores. The separator is non-flammable In a lithium-ion battery, the substrate is a first electrode, and a second electrode is in direct contact with the zeolite coating. The lithium-ion battery includes a non-flammable salt-concentrated electrolyte, and the zeolite coating has a high wettability for the electrolyte. The lithium-ion battery is non-flammable.

IPC Classes  ?

• H01M 50/383 - Flame arresting or ignition-preventing means
• H01M 50/449 - Separators, membranes or diaphragms characterised by the material having a layered structure
• H01M 50/434 - Ceramics
• H01M 50/431 - Inorganic material
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
• H01M 50/489 - Separators, membranes, diaphragms or spacing elements inside the cells, characterised by their physical properties, e.g. swelling degree, hydrophilicity or shut down properties
• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms

Abstract

Exemplary embodiments of wearable stretch sensors and applications of using the same are disclosed. In embodiments, the sensors and the applications disclosed herein can be used to capture spinal motion and posture information.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

Detecting single bacterial cells in a sample includes collecting, from a sample provided to an imaging apparatus, a multiplicity of images of the sample over a length of time; assessing a trajectory of each bacterial cell in the sample; and assessing, based on the trajectory of each bacterial cell in the sample, a number of bacterial cell divisions that occur in the sample during the length of time.

IPC Classes  ?

• G06T 7/00 - Image analysis
• C12Q 1/06 - Quantitative determination
• C12Q 1/18 - Testing for antimicrobial activity of a material
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The present invention relates to systems and methods for catalytic removal of oxidized contaminants (for example, nitrite, chromate, chlorate, trichloroethene, CFC-11, 4-nonylphenol, RDX, and perfluorooctanoate) from water and wastewater. In some aspects, the catalytic method of removing oxidized contaminants comprises using precious metal nanoparticles as catalysts to reduce the oxidized contaminants.

IPC Classes  ?

• B01J 37/00 - Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
• B01J 37/18 - Reducing with gases containing free hydrogen
• B01J 23/44 - Palladium
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• B01J 35/06 - Fabrics or filaments

Abstract

A coating composition includes alkaline mineral particles including an oxide of an alkaline earth metal and an amine-containing polymer. The amine-containing polymer is adsorbed on the alkaline mineral particles. Forming a coating composition includes at least partially coating alkaline mineral particles with an amine-containing polymer and dispersing the alkaline mineral particles in a liquid to yield the coating composition. The alkaline mineral particles include an oxide of an alkaline earth metal.

IPC Classes  ?

• C09D 177/12 - Polyester-amides
• C09D 7/61 - Additives non-macromolecular inorganic
• C09D 7/40 - Additives
• C09D 7/20 - Diluents or solvents
• C09D 7/65 - Additives macromolecular

Abstract

Provided herein are methods of quantifying protein folding and stability. Some embodiments provide methods of detecting a misfolded target protein that include determining a growth rate or relative fitness of a first cell population that comprises a first fusion polypeptide comprising a first variant of a target protein disposed between segments of a toxic indicator protein, which segments together induce the first cell population to grow at a lower rate when the target protein is relatively less misfolded than when the target protein is relatively more misfolded, and determining that the growth rate or fitness of the first cell population varies from a growth rate or fitness of a second cell population that comprises a second fusion polypeptide comprising a second variant of the target protein disposed between the segments of the toxic Indicator protein. Related nucleic acids, kits, and systems are also provided.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
• G01N 33/573 - Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Described herein are compositions comprising RNA origami (RNAOG) which include 5-fluorouracil (5FU) or analogues thereof are described which can be used to both directly treat a cancer by inhibiting a biochemical pathway overexpressed in a cancer cell and indirectly treat a cancer by inducing an anti-cancer immune response. Also described herein are methods of using said compositions for treating cancer, inducing an anti-cancer immune response, and/or killing a cancer cell.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/117 - Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• A61P 35/00 - Antineoplastic agents

Abstract

Described herein is a DNA nanotechnology-based platform for the delivery of nucleic acids into cells. The delivery platform relies on compacting cargo mRNA and/or ssDNA into single folded nanostructures that act as the primary structural vehicle material for nanoparticle delivery to cells. The described compositions and methods provide an alternative to packaging mRNA or ssDNA into lipid nanoparticle vehicles, which have complex formulation properties. Also described herein are strategies for protecting mRNA and/or ssDNA cargo and helping these nucleic acid molecules escape the endosome into the cytoplasm using a cationic peptide-PEG coating.

IPC Classes  ?

• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61K 9/50 - Microcapsules
• A61K 9/14 - Particulate form, e.g. powders
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 9/127 - Liposomes

Abstract

The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neurotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the ‘Prevotella-like enterotype’ compared to neurotypical subjects. The relative abundance of genera Prevotella, Coprococcus, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further, Prevotella, is one of the three main classifiers for the human enterotypes, along with Bacteroides and Ruminococcus. These three core genera are among main contributors in the principle component analysis. ‘Prevotella-like enterotype’ was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 35/741 - Probiotics

Abstract

A modified bitumen composition includes bitumen and a multiplicity of silica particles. Each silica particle is coupled to an acid component. Treating a modified bitumen includes contacting the modified bitumen with a flow of air and removing the flow of air after a length of time when a penetration grade of the bitumen decreases to a specified value.

IPC Classes  ?

• C04B 20/10 - Coating or impregnating
• C04B 26/26 - Bituminous materials, e.g. tar, pitch
• C04B 14/06 - Quartz; Sand
• C04B 38/10 - Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by using foaming agents

Abstract

A separator for a lithium-based battery, and method for fabricating the same is disclosed. The method includes oxidizing cellulose fibrils to form oxidized cellulose having carboxylic functional groups, decorating the oxidized cellulose with nanoparticles, and forming the nanoparticle-decorated oxidized cellulose into a film to become the separator for the lithium-based battery. The cellulose may be a bacterial cellulose. The cellulose fibrils may be oxidized through a TEMPO oxidation. Decorating the oxidized cellulose with nanoparticles may include introducing a precursor solution to the oxidized cellulose that reacts with hydroxyl groups of the oxidized cellulose while preserving the carboxylic functional groups, causing the nanoparticles to nucleate on the surface of the oxidized cellulose. The nanoparticles may be composed of an oxide material. The oxide material may be SiO2. The precursor solution may be tetraethyl orthosilicate (TEOS).

IPC Classes  ?

• H01M 50/429 - Natural polymers
• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
• H01M 50/434 - Ceramics
• H01M 50/446 - Composite material consisting of a mixture of organic and inorganic materials
• H01M 50/431 - Inorganic material

Abstract

A structural color image includes a metallic layer, a nanocomposite film, and a dielectric layer between and in direct contact with the metallic layer and the nanocomposite film. The metallic layer reflects visible light. The nanocomposite film reflects visible light and includes metallic nanoparticles in a polymeric material.

IPC Classes  ?

• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation

Abstract

Techniques are described for efficiently reducing the amount of total computation in convolutional neural networks (CNNs) without affecting the output result or classification accuracy. Computation redundancy in CNNs is reduced by exploiting the computing nature of the convolution and subsequent pooling (e.g., sub-sampling) operations. In some implementations, the input features may be divided into a group of precision values and the operation(s) may be cascaded. A maximum may be identified (e.g., by 90% probability) using a small number of bits in the input features, and the full-precision convolution may then be performed on the maximum input. Accordingly, the total number of bits used to perform the convolution is reduced without affecting the output features or the final classification accuracy.

IPC Classes  ?

• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

Contacts for solar cells and other optoelectronic devices are provided. Embodiments described herein take advantage of the surface Fermi level pinning effect to build an electrical field inside of a semiconductor to extract or inject carriers for solar cells, photodetectors, and light-emitting device applications. For example, n-type or p-type two-dimensional (2D) materials can be used in contact with an n-type semiconductor to form a “p-region” so that a p-n junction, or an i-n or n-n+ junction can be constructed. Similarly, n-type or p-type 2D materials can be used in contact with a p-type semiconductor to form an “n-region” so that an n-p junction, or an i-p or p-p+ junction can be constructed. These structures can provide sufficiently high electrical field inside the semiconductor to extract photogenerated carriers in solar cells and photodetectors or inject minority carriers for light-emitting devices.

IPC Classes  ?

• H01L 31/0224 - Electrodes
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The present invention provides nanoparticles or conjugates comprising at least one ligand that selectively targets major facilitator superfamily domain-containing protein-2a (MFSD2A). In various embodiments, the nanoparticles or conjugates of the invention target at least one cell comprising MFSD2A (e.g., endothelial cells of blood brain barrier). In some embodiments, the nanoparticles or conjugates of the invention cross the blood brain barrier and/or blood retinal barrier. In other aspects, the present invention relates to methods for in vivo delivery of diagnostic and/or therapeutic agents to a brain. In other aspects, the present invention relates to methods of preventing or treating a neurological or cognitive disease or disorder using the nanoparticles or conjugates of the invention.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 9/127 - Liposomes
• A61P 25/00 - Drugs for disorders of the nervous system
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Disclosed herein is a transmembrane nanosensor device comprising a lipid conjugated DNA tweezer, and methods of using the same.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The instant disclosure is directed to passivated silver nanoparticle coatings and methods of making the same. A method may comprise obtaining a substrate having a surface, exposing the surface to a plurality of silver nanoparticles, applying a nucleating agent to the silver nanoparticles to form a plurality of silver cores, and passivating the silver cores by applying a sulfidation agent to the silver cores to form silver sulfide shells around the silver cores, thereby forming a coating comprising a plurality of sulfidated silver nanoparticles having a core-shell structure. The method may be used to form a coating comprising a plurality of sulfidated silver nanoparticles having a core-shell structure.

IPC Classes  ?

• B22F 1/054 - Nanosized particles
• C09D 5/16 - Anti-fouling paints; Underwater paints
• B22F 1/145 - Chemical treatment, e.g. passivation or decarburisation
• B22F 1/16 - Metallic particles coated with a non-metal
• C09D 1/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
• C23C 24/00 - Coating starting from inorganic powder

Abstract

Provided herein are methods and compositions for rapid, highly sensitive detection of SARS-CoV-2 in biological samples. In particular, provided herein is a rapid, low-cost method for detecting SARS-CoV-2 that provides reliable, visible test results and does not require PCR reagents, elaborate biosafety precautions, or sophisticated laboratory equipment.

IPC Classes  ?

• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

Systems and methods for continuous flow polymerase chain reaction (PCR) are provided. The system comprises an injector, a mixer, a coalescer, a droplet generator, a detector, a digital PCR system, and a controller. The injector takes in a sample, partitions the sample into sample aliquots with the help of an immiscible oil phase, dispenses waste, and sends the sample aliquot to the mixer. The mixer mixes the sample aliquot with a PCR master mix and diluting water, dispenses waste, and sends the sample mixture (separated by an immiscible oil) to the coalescer. The coalescer coalesces the sample mixture with primers dispensed from a cassette, dispenses waste, and sends the reaction mixture (separated by an immiscible oil) to the droplet generator. The droplet generator converts the sample mixture into an emulsion where aqueous droplets of the reaction mixture are maintained inside of an immiscible oil phase and dispenses droplets to the digital PCR system. The digital PCR system amplifies target DNAs in the droplets. The detector detects target DNAs in the droplets. The controller controls the system to run automatically and continuously.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• C12Q 1/686 - Polymerase chain reaction [PCR]
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state

Abstract

The present invention relates to methods of improving cell lysis procedures and yields of intracellular biomolecules extracted from biomass. The methods comprise storing the microbial cells in ultra-low temperature (ULT) conditions for at least 10 minutes prior to lysing the cells.

IPC Classes  ?

• C12N 1/06 - Lysis of microorganisms
• C12N 1/20 - Bacteria; Culture media therefor

Abstract

The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

IPC Classes  ?

• A61L 31/14 - Materials characterised by their function or physical properties
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/20 - Interleukins
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/06 - Ointments; Bases therefor

Abstract

Described herein are engineered metabolic pathways in recombinant microorganism host cells which result in the production of 2-phenylethanol or 2-phenylacetic acid. Also described herein are methods of using the recombinant microorganisms for the production of 2-phenylethanol or 2-phenylacetic acid.

IPC Classes  ?

• C12P 7/22 - Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
• C12N 9/88 - Lyases (4.)
• C12N 1/20 - Bacteria; Culture media therefor
• C12R 1/19 - Escherichia coli

Abstract

Described herein are systems relating to a continuous-flow instrument that includes all necessary components for digital droplet quantification without the need to introduce key reagents or collect and transfer droplets between stages of instrument operation. Digital quantification can proceed without any additional fluid or consumable handling and without exposing fluids to risk of external contamination.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

Abstract

The present disclosure relates to Betulastatin compounds, pharmaceutical compositions and kits comprising such compounds, and methods for using such compounds or pharmaceutical compositions.

IPC Classes  ?

• C07J 63/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
• C07J 71/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton is condensed with a heterocyclic ring
• A61P 35/00 - Antineoplastic agents

Abstract

Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications are provided.

IPC Classes  ?

• C07D 471/14 - Ortho-condensed systems
• C07D 471/04 - Ortho-condensed systems
• C07D 495/14 - Ortho-condensed systems
• C07D 495/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
• C07D 493/22 - Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

Disclosed are recombinant Cas9 proteins, methods of production, and methods of use for targeted DNA deletions, DNA insertions, or both in a eukaryotic genome. An assay system for evaluating the ability of the recombinant Cas9 proteins for targeted DNA deletions, DNA insertions, or both in a eukaryotic genome is also disclosed.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Treating aged asphalt includes contacting aged asphalt with a bioagent to yield a mixture. The aged asphalt includes a siliceous stone component and bitumen, and the bioagent includes bio-oils formed from hybrid biomasses. The siliceous stone component and the bitumen are separated. The bioagent promotes separation of the siliceous stone from the bitumen. A rejuvenated bitumen composition includes recycled bitumen, virgin bitumen, and a bioagent. The recycled bitumen can be produced from recycled asphalt paving, and the bioagent can include bio-oils formed from hybrid biomasses.

IPC Classes  ?

• C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch

Abstract

A self-supervised learning framework for empowering instance discrimination in medical imaging using Context-Aware instance Discrimination (CAiD), in which the trained deep models are then utilized for the processing of medical imaging. An exemplary system receives a plurality of medical images; trains a self-supervised learning framework to increasing instance discrimination for medical imaging using a Context-Aware instance Discrimination (CAiD) model using the received plurality of medical images; generates multiple cropped image samples and augments samples using image distortion; applies instance discrimination learning a mapping back to a corresponding original image; reconstructs the cropped image samples and applies an auxiliary context-aware learning loss operation; and generates as output, a pre-trained CAiD model based on the application of both (i) the instance discrimination learning and (ii) the auxiliary context-aware learning loss operation.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation
• G06T 7/00 - Image analysis

Abstract

An embodiment provides a method for treating a body fluid of a patient with Covid-19, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with a virion in the body fluid to form an antibody-virion complex, wherein the antibody comprises a tag sensitive to an illumination; removing the antibody-virion complex from the body fluid using an illumination source; and returning the body fluid to the patient. Other aspects are described and claimed.

IPC Classes  ?

• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

Abstract

Relay-aided intelligent reconfigurable surfaces (IRSs) are provided. A novel relay-aided intelligent surface architecture is described herein that has the potential of achieving the promising gains of IRSs with a much smaller number of elements, opening the door for realizing these surfaces in practice. A half-duplex or full-duplex relay is connected to one or more IRSs. This merges the gains of relays and reconfigurable surfaces and splits the required signal-to-noise ratio (SNR) gain between them. This architecture can hen significantly reduce the required number of reconfigurable elements in the IRS(s) while achieving the same spectral efficiencies. Consequently, the proposed relay-aided intelligent surface architecture needs far less channel estimation/beam training overhead and provides enhanced robustness compared to traditional IRS solutions.

IPC Classes  ?

• H04B 7/155 - Ground-based stations
• H04B 7/06 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H01Q 15/14 - Reflecting surfaces; Equivalent structures
• H01Q 19/10 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces
• H01Q 19/18 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces having two or more spaced reflecting surfaces

Abstract

A modified bitumen composition includes bitumen, biomass oil including one or more phenolic compounds, and added sulfur. The modified bitumen composition includes between about 5 wt% and about 25 wt% of the added sulfur, at least some of the added sulfur is present as polysulfide chains, and at least some of the one or more phenolic compounds are configured to covalently bind to the polysulfide chains. Making a modified bitumen includes combining bitumen and elemental sulfur to yield sulfur-extended bitumen, and combining the sulfur-extended bitumen with biomass oil including one or more phenolic compounds to yield the modified bitumen.

IPC Classes  ?

• C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch

Abstract

in situin situ in situ single-cell sequencing technologies are only able to work with RNA, and must first convert DNA to RNA, the method of this disclosure operates directly on DNA as well as on RNA. Thus, it simultaneously sequences each single cell's genome and transcriptome.

IPC Classes  ?

• C12Q 1/6844 - Nucleic acid amplification reactions
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6851 - Quantitative amplification

Abstract

Organic light emitting devices (OLEDs) with emissive layers containing both phosphorescent Pt complexes and fluorescent emitters, are described. The devices presented employ both fluorescent and phosphorescent Pt complexes in order to redistribute the excited states to primarily reside on known stable fluorescent emitters to achieve high device operational stability but maintain the high efficiency characteristic of phosphorescent OLEDs.

IPC Classes  ?

• H10K 85/30 - Coordination compounds

Abstract

A consensus MHC-I binding and processing prediction workflow, methods and systems are described, for improving T-cell immunity against threats such as viruses and cancer. The methods and systems can also be used to determine population fitness against a target antigen such as a pathogen or cancer.

IPC Classes  ?

• G16B 35/20 - Screening of libraries
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Abstract

Various embodiments of a bio-inspired robot operable for detecting crack and corrosion defects in tubular structures are disclosed herein.

IPC Classes  ?

• B25J 9/16 - Programme controls

Abstract

Described herein are DNA nanostructures (DN) functionalized with proteins and methods for cellular uptake. Cellular uptake of such DNs is linearly dependent on the cell size. The protein corona determines the endolysosomal vesicle escape efficiency of DNs coated with an endosome escape peptide.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Abstract

Disclosed herein are methods to improve effectiveness of cancer vaccines by increasing high affinity T cells number. Methods of eliciting an immune response in a treatment subject in need thereof and methods of treating cancer and/or a tumor in a subject are also disclosed.

IPC Classes  ?

• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Disclosed herein are systems and methods for Magnetic Resonance Electrical Impedance Tomography (MREIT). A system for imaging biological tissue comprises a controller, a multifrequency arbitrary-waveform constant-current source, a Howland constant-current source, and a digital-to-analog converter. The controller is configured to generate a multifrequency magnetic resonance electrical impedance tomography sequence. The generation comprises producing, by the controller, a digital sequence, and converting, by the digital-to-analog converter, the digital sequence to an analog sequence. The generation may further comprise: producing, by the Howland constant-current source, a standard magnetic resonance electrical impedance tomography sequence based on the analog sequence; producing, by the multifrequency arbitrary-waveform constant-current source, a sine wave at one or more predetermined frequencies; and modulating the standard magnetic resonance electrical impedance tomography sequence with the sine wave. A method of measuring an electrical property of a biological tissue comprises imaging the biological tissue using this system.

IPC Classes  ?

• A61B 5/0536 - Impedance imaging, e.g. by tomography
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/54 - Signal processing systems, e.g. using pulse sequences

Abstract

Provided herein are methods of tracking molecular dynamics in three dimensions. In some embodiments, the methods include introducing an incident light toward a second surface of a substrate to induce a plasmonic wave at least proximal to a first surface of the substrate. A population of particles is connected to the first surface of the substrate via one or more first biomolecules. In some embodiments, the methods also include detecting a change in position of the particles in the population along at least three dimensions over a duration from a change in intensity of the incident light reflected at an interface of the first surface of the substrate. Related systems and computer readable media are also provided.

IPC Classes  ?

• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Abstract

Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
• G01N 27/327 - Biochemical electrodes
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol

Abstract

Provided herein are methods of identifying neoantigens for diagnosing, treating, and preventing cancer. Also provided herein are methods of measuring antibody response to one or more frameshift peptides caused by exon 1 mis-initiation. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

Disclosed is a calcium salt, Ca(HMDS)2, where HMDS is the hexamethyldisilazide anion (also known as bis(trimethylsilyl)amide), enables high current densities and high coulombic efficiency for calcium metal deposition and dissolution. These properties facilitate the use of this salt in batteries based on calcium metal. In addition, the salt is significant for batteries based on metal anodes, which have higher specific energies than batteries based on intercalation anodes, such as LiC6. In particular, a calcium based rechargeable battery includes Ca(HMDS)2 salt and at least one solvent, the solvent suitable for calcium battery cycling. The at least one solvent can be diethyl ether, diisopropylether, methyl t-butyl ether (MTBE), 1,3-dioxane, 1,4-dioxane, tetrahydrofuran (THE), tetrahydropyran, glyme, diglyme, triglyme or tetraglyme, or any mixture thereof.

IPC Classes  ?

• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 10/44 - Methods for charging or discharging
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

The present disclosure relates to methods for monitoring effectiveness of a treatment of an autism spectrum disorder (ASD) by analyzing an ASD patient's gut microbiota based on stool samples. Also provided are software for implementing the methods, and kits for performing the methods.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61K 35/74 - Bacteria
• A61K 35/741 - Probiotics
• A61K 35/745 - Bifidobacteria

Abstract

Disclosed herein, in some embodiments, are modified Serp-1 proteins. The modified Serp-1 protein may include a therapeutic enhancing moiety, and be biologically active. In some cases, the therapeutic enhancing moiety is a water soluble polymer such as polyethylene glycol.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• C07K 14/81 - Protease inhibitors
• A61P 7/04 - Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Using deep learning, imaging harmonization among images produced with differing PET tracers is achieved. A method may include providing an original PET image of the brain using an original PET tracer, providing a target PET tracer, and converting, using a deep learning neural network, the original PET image into a target PET image simulating the image that would be obtained had the target PET tracer been used.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
• G01R 33/48 - NMR imaging systems