Abstract

A computing system includes a processor having access to data associated with a plurality of devices of a network. The processor is configured to leverage the data to execute a loss model that estimates cyber risk loss distribution of the network associated with healthcare environment and infrastructure using bond percolation on a mixed random graphs approach.

IPC Classes  ?

• G06Q 40/12 - Accounting
• G06Q 50/26 - Government or public services

Abstract

Provided herein is a vaccination composition that comprises a recombinant immune complex (RIC) that includes an immunoglobulin heavy chain; an epitope tag, wherein the immunoglobulin heavy chain binds the epitope tag; and at least a fragment of a herpes simplex virus (HSV) type 2 glycoprotein D (HSV2 glycoprotein D). Related methods, recombinant vectors, and other aspects are also provided.

IPC Classes  ?

• A61K 39/42 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
• A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus

Abstract

Provided herein are lipid nanoparticle complex with nanoparticles cloaked in monocyte plasma membrane for effective delivery of drugs. Also provided herein are drug loaded lipid nanoparticle complex for inhibition of YAP/TAZ pathway and methods of using the lipid nanoparticles for treatment of atherosclerosis in a subject in need thereof.

IPC Classes  ?

• A61K 9/127 - Liposomes
• A61K 9/51 - Nanocapsules
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

A system and method for the automatic stimulation of a vagus nerve for post-stroke rehabilitation is disclosed. The system includes an application subsystem having an electrode positioned to stimulate the vagus nerve and coupled to a user outside of a surgical setting. The system also includes a waveform generator communicatively coupled to the electrode, and a triggering subsystem including a receiver configured to detect the presence of a tag. The triggering subsystem is communicatively coupled to waveform generator and is configured to automatically trigger the stimulation of the vagus nerve upon detecting the presence of the tag. The tag is located proximate a rehabilitation context such that the tag is detected when the user is using the rehabilitation context, resulting in the vagus nerve of the user being automatically stimulated by the electrode in response to the user's post-stroke rehabilitation training.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes
• A61N 5/06 - Radiation therapy using light

Abstract

Described herein are mRNA carrier systems and methods of their use for entering the cytoplasm and expressing carried mRNA, to induce a tumor killing effect. The mRNA carrier systems can comprise DNA or RNA nanostructures. Also described herein are methods of treating cancer using the mRNA carrier systems described herein.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/00 - Antineoplastic agents
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/86 - Viral vectors

Abstract

A solid electrolyte represented by general formula LiySiRx(MO4), where x is an integer from 1 to 3 inclusive, y=4−x, each R present is independently C1-C3 alkyl or C1-C3 alkoxy, and M is sulfur, selenium, or tellurium. Methods of making the solid electrolyte include combining a phenylsilane and a first acid to yield mixture including benzene and a second acid, and combining at least one of an alkali halide, and alkali amide, and an alkali alkoxide with the second acid to yield a product d represented by general formula LiySiRx(MO4)y. The second acid may be in the form of a liquid or a solid. The phenylsilane includes at least one C1-C3 alkyl substituent or at least one C1-C3 alkoxy substituent, and the first acid includes at least one of sulfuric acid, selenic acid, and telluric acid.

IPC Classes  ?

• H01M 10/0564 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes the electrolyte being constituted of organic materials only
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries

Abstract

A composite material includes an adsorbent support having a carbon block structure defining pores, and titanium (hydr)oxide particles or films bound to the carbon block structure inside the pores. Preparing the composite material includes contacting a porous support having a carbon block structure defining pores with a solution including a solvent and a titanium (hydr)oxide precursor to yield a precursor material, and drying the precursor material to yield a titanium (hydr)oxide-impregnated carbon block. Synthesizing hybrid titanium (hydr)oxides includes combining a solution including a titanium (hydr)oxide precursor and a solvent with one or more metal precursors to yield a precursor solution, and heating the precursor solution to yield the hybrid titanium (hydr)oxides.

IPC Classes  ?

• B01J 21/06 - Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
• B01J 21/18 - Carbon
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties

Abstract

A continuous CO2 capture system, method, and device are disclosed. The device includes a CO2 pump membrane including a moisture-swing material, and a cavity having a first fluid. The CO2 pump membrane separates the first fluid from a second fluid, the fluids creating a water concentration gradient across the membrane and transport of water through the membrane. The water concentration gradient creates a carbon concentration gradient across the membrane that decreases moving from outside the cavity to inside the cavity. As water is continuously transported from the first fluid to the second fluid through the CO2 pump membrane because of the water concentration gradient, carbon dioxide is continuously captured from the second fluid by the moisture-swing material of the CO2 pump membrane and continuously pumped along the carbon concentration gradient across the CO2 pump membrane and into the first fluid within the cavity.

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion

Abstract

This disclosure describes systems and methods for critical angle reflection (CAR) imaging to quantify molecular binding kinetics on a glass surface in some embodiments. CAR is a label-free method that measures the reflectivity change near a critical angle in response to molecular binding induced refractive index changes on the sensor surface. The sensitivity and dynamic range of CAR is tunable by varying the incident angle of light, which allows for optimizing the measurement for ligands with different sizes in both biomolecular and cell-based studies.

IPC Classes  ?

• G01N 21/43 - Refractivity; Phase-affecting properties, e.g. optical path length by measuring critical angle
• G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Abstract

A nanocomposite electrode includes a porous copper substrate, Co3O4 and/or Cu/Co(OH)x nanoparticles electrolytically deposited on the porous copper substrate. Fabricating the nanocomposite electrode includes contacting the porous copper substrate with a solution comprising cobalt, and electrodepositing the cobalt on the porous copper substrate to yield the nanocomposite electrode. Reducing nitrate to ammonia includes contacting the nanocomposite electrode with an aqueous solution comprising nitrate, and electrocatalytically reducing the nitrate to yield ammonia.

IPC Classes  ?

• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• C25B 1/27 - Ammonia
• C25B 11/031 - Porous electrodes
• C25B 11/061 - Metal or alloy

Abstract

Provided herein are computer-implemented methods of generating a disease map of a population. In some embodiments, the methods include applying a clustering algorithm to a set of weight and bias values of a trained electronic neural network to generate the disease map of the population. In some embodiments, the electronic neural network has been trained on training data that comprises representations of peptide sequence and binding value pair data sets obtained from reference subjects in the population in which a given peptide sequence and binding value pair data set comprises peptide sequence information and peptide binding values of antibodies to peptides that comprises the peptide sequence information. In some embodiments, the antibodies are from a sample obtained from a given reference subject in the population and are indicative of one or more disease states. Related systems, computer readable media, and additional methods are also provided.

IPC Classes  ?

• G06N 3/02 - Neural networks
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06F 16/29 - Geographical information databases
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

Provided herein are nanostructures comprising peptides specific for the extracellular domains of HER1 and/or HER3. Also provided herein are methods for use of the nanostructures to aggregate cells and deliver therapeutic agents to the cells. The nanostructures and methos are useful for treating and/or preventing cancers or other conditions associated with HER1 and/or HER3 overexpression.

Abstract

The disclosure relates to methods of detecting a target nucleic acid in a sample using a deactivated RNA-guided nuclease and guide RNA complex. Some methods relate to isolating protein-nucleic acid complexes using silica-based chromatography with certain buffered solutions to better prevent complex dissociation. Some methods relate to isolating protein-nucleic acid complexes using a tagged ribonucleoprotein which binds to a target nucleic acid to form a detectable interconnected network comprising the target nucleic acid. Also provided herein are primer nucleic acids, buffer solutions, and kits for performing the methods of this disclosure for detecting a target nucleic acid in a sample.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

Provided herein are dynamic adaptive scheduling (DAS) systems. In some embodiments, the DAS systems include a first scheduler, a second scheduler that is slower than the first scheduler, and a runtime preselection classifier that is operably connected to the first scheduler and the second scheduler, which runtime preselection classifier is configured to effect selective use of the first scheduler or the second scheduler to perform a given scheduling task. Related systems, computer readable media, and additional methods are also provided.

IPC Classes  ?

• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt
• G06F 9/54 - Interprogram communication

Abstract

Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery

Abstract

The present invention relates to methods for biological wastewater treatment for Se control in Se-laden wastewater. The Se contaminants in the wastewater include the Se oxyanions selenate (SeO42-) and selenite (HSeO3−), which are biochemically reduced and transformed to elemental selenium (Se0) by microorganisms through anaerobic biological reduction. The resulting Se0 is entrained in the biomass, which is further processed to enable the efficient recovery of concentrated Se0.

IPC Classes  ?

• C02F 9/00 - Multistage treatment of water, waste water or sewage
• B01D 71/02 - Inorganic material

Abstract

A system and associated methods for accurate localization of seizure onset zone (SOZ) from independent components (IC) of resting state functional magnetic resonance imaging (rs-fMRI) to improve surgical outcomes in children with Drug Resistant Epilepsy (DRE) are disclosed. The system and methods define a phased approach, where fMRI noise-related biomarkers are used through high fidelity image processing techniques to eliminate noise ICs. Then SOZ markers are used through a maximum likelihood-based classifier to determine SOZ localizing ICs.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G06T 7/00 - Image analysis

Abstract

A processor is configured to implement a machine learning model that is trained to select transcripts in blood for distinguishing neurodegenerative diseases. The algorithm is developed via machine learning and leverages concepts associated with blood-based changes in mRNA gene expression for differentiating patients of any neurodegenerative disease regardless of the proteins or their post-translational modifications occurring in disease.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 20/20 - Ensemble learning
• G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
• G16B 40/20 - Supervised data analysis
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

Provided herein, in some embodiments, are engineered cells and use of the same for increased hydrogen production. In particular, provided herein are genetically engineered cells comprising a polynucleotide encoding a fusion protein comprising a photosystem I (PSI) protein and a bacterial hydrogenase, as well as methods for producing such genetically engineered cells. Also provided herein are methods for increasing hydrogen (H2) production in cells.

IPC Classes  ?

• C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
• C07K 14/405 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

Provided herein are highly modular and sensitive biosensors for small molecule detection using CRISPR/C as enzymes having collateral single-stranded nucleic acid cleavage activity. Also provided herein are uses of the biosensors in detection platforms for convenient, low-cost assessment of safety and purity of consumable samples, environmental samples, and agricultural products.

IPC Classes  ?

• G01N 33/94 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics
• C12Q 1/6823 - Release of bound markers
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

A method for increasing the temperature-resiliency of a neural network, the method comprising loading a neural network model into a resistive nonvolatile in-memory-computing chip, training the deep neural network model using a progressive knowledge distillation algorithm as a function of a teacher model, the algorithm comprising injecting, using a clean model as the teacher model, low-temperature noise values into a student model and changing, now using the student model as the teacher model, the low-temperature noises to high-temperature noises, and training the deep neural network model using a batch normalization adaptation algorithm, wherein the batch normalization adaptation algorithm includes training a plurality of batch normalization parameters with respect to a plurality of thermal variations.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/0495 - Quantised networks; Sparse networks; Compressed networks

Abstract

Synthetic antimicrobial peptides, compositions comprising thereof, and methods of use for modulating one or more symptoms of an infection in a subject are disclosed. In some aspects, the infection is caused by mycobacteria, for example, a nontuberculous mycobacterium such as Mycobacterium abscessus. In other aspects, the infection is caused by Escherichia coli, Pseudomonas aeruginosa, or methicillin-resistant Staphylococcus aureus (MRSA). Also disclosed are methods of identifying synthetic antimicrobial peptides against a pathogen with no known effective treatment using a library of synthetic peptides.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• A61P 31/04 - Antibacterial agents
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/86 - Viral vectors

Abstract

Systems and methods for a wearable “exo-shell” to improve the gait of elderly people during obstacle avoidance tasks are disclosed. With payload and energy expenditure as a main focus of this design, the present system leverages switchable, passive systems, in combination with lightweight materials that minimize additional metabolic costs, while remaining as “transparent” to the user as possible when inactive.

IPC Classes  ?

• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about

Abstract

A consensus-based decentralized multi-robot approach is presented for reconstructing a discrete distribution of features, modeled as an occupancy grid map, that represent information contained in a bounded planar 2D environment, such as visual cues used for navigation or semantic labels associated with object detection. The robots explore the environment according to a random walk modeled by a discrete-time discrete-state (DTDS) Markov chain and estimate the feature distribution from their own measurements and the estimates communicated by neighboring robots, using a distributed Chernoff fusion protocol. Under this decentralized fusion protocol, each robot's feature distribution converges to the ground truth distribution in an almost sure sense.

IPC Classes  ?

• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters
• G05D 1/10 - Simultaneous control of position or course in three dimensions
• G06V 10/84 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using probabilistic graphical models from image or video features, e.g. Markov models or Bayesian networks
• G06V 20/17 - Terrestrial scenes taken from planes or by drones
• H04W 4/46 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for vehicle-to-vehicle communication [V2V]

Abstract

A system, device, and method for passive collection of atmospheric carbon dioxide is disclosed. The device includes a release chamber having a sorbent regeneration system with a power supply, and a capture structure coupled to the release chamber, having a plurality of disks coupled to and spaced along at least one collapsible support. Each disk has an electro-swing sorbent material. The capture structure is movable between collection and release configurations. The collection configuration includes the capture structure extending upward to expose the structure to an airflow and allow the sorbent to capture atmospheric carbon dioxide while a collection voltage is established across the sorbent material. The release configuration includes the disks enclosed inside the release chamber and conductively coupled to the power supply such that a release voltage is established across the electro-swing sorbent material, resulting in the release of captured carbon dioxide forming an enriched gas.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group

Abstract

Based on traffic images characteristics, a general pre-processing system and method reduces input size of neural network object recognition models to focus on necessary regions. The system includes a light neural network (binary or low precision; based on configuration) to detect target regions for further processing and applies a deeper model to those specific regions. The present disclosure provides experimentation results on various types of methods, such as conventional convolutional neural networks, transformers, and adaptive models, to show the scalability of the system.

IPC Classes  ?

• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/54 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects of traffic, e.g. cars on the road, trains or boats

Abstract

The disclosure provides Myxoma viruses that express one or more multi-specific immune cell engagers, such as BiKE, BiTE and/or MiTE and their use in inhibiting and/or treating a hematological cancer in a subject. The disclosure also provides a leukocyte having a Myxoma virus that expresses one or more multi-specific immune cell engagers, and the use of the leukocyte for inhibiting and/or treating a hematological cancer in a subject.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
• A61K 35/768 - Oncolytic viruses not provided for in groups
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The disclosure provides Myxoma virus that expresses one or more immunomodulatory transgenes and its use in inhibiting and/or treating a hematological cancer in a subject. The disclosure also provides a leukocyte having a Myxoma virus that expresses one or more immunomodulatory transgenes and the use of the leukocyte for inhibiting and/or treating a hematological cancer in a subject.

IPC Classes  ?

• A61K 35/768 - Oncolytic viruses not provided for in groups
• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
• A61P 33/00 - Antiparasitic agents

Abstract

Systems and methods are provided for predicting microhardness properties of a weld that defines a weld joint between at least two workpieces. The system includes a processor programmed to: receive temperature data that includes temperature values each attributed to a corresponding one of a plurality of points of the weld at corresponding times during a welding process used to produce the weld, determine peak temperature values and cooling rate values for each of the points of the weld based on the temperature values, predict a three-dimensional (3D) distribution of microhardness values of the weld based on a machine learning method that evaluates the peak temperature values and the cooling rate values, and generate display data based on the 3D distribution of microhardness values.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• B23K 9/095 - Monitoring or automatic control of welding parameters

Abstract

A bitumen composite includes an amine-impregnated zeolite and bitumen. Forming the bitumen composite includes combining bitumen and an amine-impregnated zeolite to yield a mixture, heating the mixture to yield the bitumen composite.

IPC Classes  ?

• C08K 9/12 - Adsorbed ingredients
• C01B 39/02 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
• C08J 3/20 - Compounding polymers with additives, e.g. colouring
• C08K 3/36 - Silica
• C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch

Abstract

A high efficiency wide-voltage-gain power conversion system and method is disclosed. The system includes a variable-inverter-rectifier-transformer (VIRT) having four pairs of switches forming four half-bridges. Each pair of switches has a top and bottom switch, with the top switch being in one state of "on" and "off" and the bottom switch being in the other state. The states of the four pairs is described by a vector associated with a segment voltage output by the VIRT. The system also includes a converter having a transformer communicatively coupled to the VIRT such that cycling the VIRT through a sequence of vectors generates a waveshape that drives a flux inside a center post of the transformer. The VIRT interfaces with a first voltage, and the converter interfaces with a second. At least one of the input and output voltages varies across a wide voltage range.

IPC Classes  ?

• H01F 21/02 - Variable inductances or transformers of the signal type continuously variable, e.g. variometers

Abstract

A Raman spectroscopy probe includes a lens tube and an objective lens positioned in the lens tube. The lens tube and the objective lens are composed of microwave transparent materials. A Raman spectroscopy system includes the Raman spectroscopy probe, a microwave reactor having a microwave reactor chamber, a susceptor crucible positioned in the microwave reactor chamber, and a sample crucible positioned in the susceptor crucible. An end of the lens tube is configured to be positioned in the microwave reactor chamber to face an opening of the sample crucible. The Raman spectroscopy system can further include an optics assembly.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01N 1/44 - Sample treatment involving radiation, e.g. heat

Abstract

A self-supervised machine learning method and system for learning visual representations in medical images. The system receives a plurality of medical images of similar anatomy, divides each of the plurality of medical images into its own sequence of non-overlapping patches, wherein a unique portion of each medical image appears in each patch in the sequence of non-overlapping patches. The system then randomizes the sequence of non-overlapping patches for each of the plurality of medical images, and randomly distorts the unique portion of each medical image that appears in each patch in the sequence of non-overlapping patches for each of the plurality of medical images. Thereafter, the system learns, via a vision transformer network, patch-wise high-level contextual features in the plurality of medical images, and simultaneously, learns, via the vision transformer network, fine-grained features embedded in the plurality of medical images.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06V 10/54 - Extraction of image or video features relating to texture
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The system receives a plurality of medical images and integrates Self-Supervised machine Learning (SSL) instructions for performing a discriminative learning operation, a restorative learning operation, and an adversarial learning operation into a model for processing the received plurality of medical images. The model is configured with each of a discriminative encoder, a restorative decoder, and an adversarial encoder. Each of the discriminative encoder and the restorative decoder are configured to be skip connected, forming an encoder-decoder. Step-wise incremental training to incrementally train each of the discriminative encoder, the restorative decoder, and the adversarial encoder is performed, in particular: pre-training the discriminative encoder via discriminative learning; attaching the pre-trained discriminative encoder to the restorative decoder to configure the encoder-decoder as a pre-trained encoder-decoder; and training the pre-trained encoder-decoder of the model using joint discriminative and restorative learning. The pre-trained encoder-decoder is associated with the adversarial encoder. The pre-trained encoder-decoder associated with the adversarial encoder is trained through discriminative, restorative, and adversarial learning to render a trained model for the processing of the received plurality of medical images. The plurality of medical images are processed through the model using the trained model.

IPC Classes  ?

• G06N 3/0895 - Weakly supervised learning, e.g. semi-supervised or self-supervised learning
• G06N 3/0455 - Auto-encoder networks; Encoder-decoder networks
• G06T 7/00 - Image analysis
• G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/50 - Context or environment of the image
• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations

Abstract

Methods and systems for the detection and quantification of multiplicity of ionic analytes comprising bromide, phosphate, sulfite, thiosulfate, thiocyanate, and formate, and optionally fluoride, chloride, chromate, selenate, perchlorate, nitrate, nitrite, and sulfate, using ion chromatography and suppressed ion conductivity. The method comprises loading a sample loop with a sample; injecting the sample from the sample loop into a column with an eluent, wherein the column comprises a guard column and an analytical column; separating, with the column, the injected sample at an effective separation temperature the injected sample in the presence of an organic modifier into a multiplicity of detectable ionic analytes; suppressing, with a suppressor, background signal; and detecting, with a detector, the multiplicity of ionic analytes.

IPC Classes  ?

• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion

Abstract

A micro-power generator for portable applications with a micro-scale reformer tube having a diameter of 3mm or less, a plurality of fuel cells within a main reactor chamber, each of the plurality of fuel cells coupled in a cantilevered fashion at a first end to a substrate, the micro-scale reformer configured to receive a fuel/air mixture through an intake. The micro-power generator receives fuel and converts the fuel within the main reactor to a syngas through use of thermal partial oxidation without subsequent formation of soot, and then electrochemically converts the synthesis gas to generate electricity. The reform reaction is made self-sustaining, at least in part, by the heat introduced to the at least one reformer tube by waste gas expelled into the main reactor chamber when an equivalence ratio is maintained above a threshold ratio.

IPC Classes  ?

• H01M 8/0612 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants from carbon-containing material
• H01M 8/1246 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides

Abstract

A safety-guaranteed control system for automated vehicles (AVs) considers both vehicle and tire stabilities on varying road conditions. Conventional AV control systems may not be sufficient to adequately handle control-dependent and time-varying safety constraints. The system integrates control-dependent barrier functions (CDBF) and time-varying CBFs (TCBFs) with control Lyapunov functions (CLFs) in a quadratic programming problem.

IPC Classes  ?

• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles

Abstract

A system implements a Policy-Governed Content Mediation Model for Mobile Augmented Reality (MAR) applications (MAR-Apps) by regulating the real-time interaction between digital MAR content, e.g., 3D objects displayed on top of a video stream, and the actual physical world. The system regulates the way MAR content is distributed inside physical spaces by means of the specification, evaluation, and enforcement of user-friendly authorization policies based on security-relevant information, a.k.a., attributes, ultimately resulting in the avoidance of unwanted content distribution and/or unwanted user interactions. Consequently, the system protects sensitive spaces as only authorized MAR content is authorized to merge with the physical surroundings. Additionally, the system allows benign multi-user interactions and respects the users' privacy by granting and enforcing management over user-supplied sensitive information.

IPC Classes  ?

• G06T 19/00 - Manipulating 3D models or images for computer graphics
• H04L 67/131 - Protocols for games, networked simulations or virtual reality
• H04L 67/52 - Network services specially adapted for the location of the user terminal

Abstract

Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.

IPC Classes  ?

• G01N 23/20025 - Sample holders or supports therefor
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01L 3/02 - Burettes; Pipettes
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present invention relates anti-microbial antibody signatures related to lung tumors, including benign tumors and adenocarcinomas. Disclosed herein are antibody panels comprising antigens from bacteria and/or viruses for use in early and accurate diagnosis of lung cancer and for reducing false positive lung carcinoma diagnoses from CT screening.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• G01N 33/539 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent

Abstract

A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product.

IPC Classes  ?

• C04B 7/19 - Portland cements
• C04B 7/46 - Burning; Melting electric
• C04B 7/38 - Preparing or treating the raw materials individually or as batches
• C04B 9/20 - Manufacture, e.g. preparing the batches
• C04B 40/02 - Selection of the hardening environment
• C04B 7/36 - Manufacture of hydraulic cements in general
• C04B 28/04 - Portland cements

Abstract

Treating plastic particles for use in concrete includes combining plastic particles with oil to yield a mixture, heating the mixture to yield a heated mixture, cooling the heated mixture to yield a cooled mixture, and removing excess oil from the cooled mixture to yield oil-treated plastic particles (e.g., oil-treated plastic particles for concrete). In one example, the oil is vegetable oil. The vegetable oil can be soybean oil, corn oil, canola oil, safflower oil, peanut oil, olive oil, grape seed oil, cocoa butter, palm oil, rice bran oil, or a combination thereof. The oil can be waste oil (e.g., waste vegetable oil, such as that recovered from restaurants). The plastic particles can be derived from post-consumer plastic, such as recycled plastic. In one example, the post-consumer plastic includes mixed plastics. A concrete composition can include rocks, sand, cement, and the oil-treated plastic particles.

IPC Classes  ?

• C04B 18/30 - Mixed waste; Waste of undefined composition, e.g. municipal waste
• B09B 3/21 - Agglomeration, binding or encapsulation of solid waste using organic binders or matrix
• B09B 3/40 - Destroying solid waste or transforming solid waste into something useful or harmless involving thermal treatment, e.g. evaporation

Abstract

The invention encompasses polysalt compositions, methods of use, and materials thereof.

IPC Classes  ?

• C08L 81/06 - Polysulfones; Polyethersulfones

Abstract

Described are platforms, systems, media, and methods for maintaining a database of items associated with one or more skill requirements and a visit duration; maintaining a database of experts associated with one or more skill proficiencies, a location, and a schedule; receiving a request from a consumer for delivery by an expert of one or more items in the database to a consumer address; identifying experts in the database having skill proficiencies matching the skill requirements of the one or more items and available in a timeslot for the visit duration of the one or more items; presenting timeslots for which one or more experts are identified to the consumer and allowing the consumer to select a timeslot; and selecting an expert from among the identified experts in the selected timeslot based on shortest travel time; provided that utilization of the selected expert exceeds a predetermined utilization threshold.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• G10L 25/66 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for extracting parameters related to health condition
• G10L 15/22 - Procedures used during a speech recognition process, e.g. man-machine dialog
• G10L 15/02 - Feature extraction for speech recognition; Selection of recognition unit
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising

Abstract

Forming a lithium lanthanum zirconate thin film includes disposing zirconium oxide on a substrate to yield a zirconium oxide coating, contacting the zirconium oxide coating with a solution including a lithium salt and a lanthanum salt, heating the substrate to yield a dried salt coating on the zirconium oxide coating, melting the dried salt coating to yield a molten salt mixture, reacting the molten salt mixture with the zirconium oxide coating to yield lithium lanthanum zirconate, and cooling the lithium lanthanum zirconate to yield a lithium lanthanum zirconate coating on the substrate. In some cases, the zirconium oxide coating is contacted with an aqueous molten salt mixture including a lithium salt and a lanthanum salt, the molten salt mixture is reacted with the zirconium oxide coating to yield lithium lanthanum zirconate, and the lithium lanthanum zirconate is cooled to yield a lithium lanthanum zirconate coating on the substrate.

IPC Classes  ?

• C23C 22/70 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using melts
• C23C 16/40 - Oxides
• C23C 28/04 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and only coatings of inorganic non-metallic material
• H01M 10/0562 - Solid materials
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• C23C 22/05 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
• C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material

Abstract

A method for deep learning video microscopy-based antimicrobial susceptibility testing of a bacterial strain in a sample by acquiring image sequences of individual bacterial cells of the bacterial strain in a subject sample before, during, and after exposure to each antibiotic at different concentrations. The image sequences are compressed into static images while preserving essential phenotypic features. Data representing the static images are input into a pre-trained deep learning (DL) model which generates output data; and antimicrobial susceptibility for the bacterial strain is determined from the output data.

IPC Classes  ?

• C12Q 1/18 - Testing for antimicrobial activity of a material
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
• G06T 7/00 - Image analysis

Abstract

A system includes a Bayesian Spatiotemporal Graph Transformer (B-STAR) architecture that models spatial and temporal relationship of multiple agents under uncertainties. The system enables Multi-Agent Trajectory Prediction for safety-critical engineering applications, (e.g., autonomous driving and flight systems) and considers the impact of various sources, such as environmental conditions, pilot/controller behaviors, and potential conflicts with nearby aircraft. It is shown that B-STAR achieves state-of-the-art performance on the ETH/UCY pedestrian dataset with UQ competence.

IPC Classes  ?

• G06N 3/047 - Probabilistic or stochastic networks
• G06N 3/0455 - Auto-encoder networks; Encoder-decoder networks
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

The present invention relates anti-microbial antibody signatures of inflammatory bowel disease and their use in early and accurate diagnosis of disease including ulcerative colitis (UC) and Crohn's disease (CD).

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.

IPC Classes  ?

• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

Provided herein are highly sensitive compositions and methods for detection of at least one specific nucleic acid molecule in a sample. The presence of a specific nucleic acid provides a positive indicator of a pathogenic agent, contaminant, non-canonical bases, and/or wild-type or mutated genes in a sample or a cell. Applications for which the compositions and methods are particularly well suited include point-of-care disease diagnosis or cellular RNA imaging.

IPC Classes  ?

• C12N 15/67 - General methods for enhancing the expression
• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Abstract

Apparatuses, systems, and methods for electrical field-assisted heterogeneous material printing (EF-HMP) of metal-polymer composite structure include a printing platform, a solution tank, an optical projection system, and an electrical field generation and control module. An additive manufacturing method for a metal-polymer composite structure includes preparing a photocurable electrolyte solution by mixing a photocurable liquid resin with a conductive nanofiller, a metal salt solution, a photo initiator, and deionized water. The method further includes initiating photopolymerization of the photocurable liquid resin to form a photocured polymer matrix by directing a projection of ultraviolet light energy from a light source onto the photocurable electrolyte solution. The method further includes depositing a metal structure onto the photocured polymer matrix. In this manner, both the photopolymerization and the metal electrodeposition are performed using the same photocurable electrolyte solution.

IPC Classes  ?

• C25D 1/00 - Electroforming
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor

Abstract

The present disclosure relates to methods of culturing algae that overcomes catabolic repression of photosynthesis in mixotrophic growth.

IPC Classes  ?

• C12N 1/12 - Unicellular algae; Culture media therefor
• A01G 33/00 - Cultivation of seaweed
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

A carbon dioxide capture composition includes a hydroxide-ion-exchanged poly(N-vinyl guanidine)-based polymer material as a sorbent. A method of preparing the carbon dioxide capture composition includes contacting a poly(N-vinyl guanidine)-based polymer material with hydroxide ion exchange beads, and exchanging hydroxide ion into the poly(N-vinyl guanidine)-based polymer material to form the sorbent. A carbon dioxide capture method includes contacting the sorbent with a gas stream, and sorbing carbon dioxide in the gas stream with the sorbent. A carbon dioxide capture system includes a sorption bed having a hydroxide-ion-exchanged poly(N-vinyl guanidine)-based polymer material as a sorbent.

IPC Classes  ?

• B01D 53/62 - Carbon oxides
• B01D 53/96 - Regeneration, reactivation or recycling of reactants
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/30 - Controlling by gas-analysis apparatus
• C08F 126/02 - Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/34 - Regenerating or reactivating

Abstract

Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.

IPC Classes  ?

• C12N 9/88 - Lyases (4.)
• C07K 19/00 - Hybrid peptides
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

A neural network accelerator architecture for multiple task adaptation comprises a volatile memory comprising a plurality of subarrays, each subarray comprising M rows and N columns of volatile memory cells; a source line driver connected to a plurality of N source lines, each source line corresponding to a column in the subarray; a binary mask buffer memory having size at least N bits, each bit corresponding to a column in the subarray, where a 0 corresponds to turning off the column for a convolution operation and a 1 corresponds to turning on the column for the convolution operation; and a controller configured to selectively drive each of the N source lines with a corresponding value from the mask buffer; wherein each column in the subarray is configured to store a convolution kernel.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

The present disclosure provides an implantable optogenetic stimulation device. In one embodiment the device includes a housing and an optoelectronic stimulation circuit for light delivery for optogenetic stimulation. The stimulation circuit includes energy harvesting circuitry to receive radio frequency (RF) energy; one or more capacitor storage elements to store energy associated with the RF energy; a light emitting diode (LED) to generate a light source for optogenetic stimulation at a selected frequency and duty cycle; and controller circuitry to discharge the one or more capacitor storage elements at a selected duty cycle to cause the LED to generate pulsed light at the selected duty cycle with energy requirement above the peak power capability of the RF harvesting circuit.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/40 - Applying electric fields by inductive or capacitive coupling

Abstract

A system for collecting a sorbate gas from a sorbent is disclosed, including a regeneration vessel enclosing a sorbent having a sorbate gas, a liquid water supply heated to a first temperature, and a heat pump with a condenser. The heat pump is also in contact with the water supply. Heat is removed from the condenser and used to heat the water supply to the first temperature. The system includes a compressor coupled to the condenser. The sorbent within the vessel is placed in contact with water vapor at the first temperature. The water vapor coming into contact with the sorbent causes sorbate gas to be released, forming a mixture including sorbate and water gases, raising the pressure. The vapor mixture is removed and cooled by the condenser, where a portion is condensed into water that is returned to the supply. The remaining mixture is compressed into a product gas.

IPC Classes  ?

• B01D 53/047 - Pressure swing adsorption
• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

A biofilm membrane bioreactor system with a bioreactor, at least two membrane plates positioned within the bioreactor, and a plurality of biofilm carriers suspended within the wastewater in the bioreactor. The bioreactor has at least one inlet and at least one outlet. The at least two membrane plates are configured to filter the wastewater to generate permeate and may be formed of a ceramic material. Each of the at least two membrane plates are separated from adjacent membrane plates by a membrane gap that is at least two times larger than a smallest dimension of one of the biofilm carriers.

IPC Classes  ?

• C02F 3/28 - Anaerobic digestion processes
• C02F 3/08 - Aerobic processes using moving contact bodies
• C02F 3/10 - Packings; Fillings; Grids
• C02F 3/12 - Activated sludge processes

Abstract

Provided are antibodies specific for human QSOX1 and methods of using these antibodies or antigen binding regions thereof in assays to detect QSOX1, to inhibit QSOX1, for use in other assay systems, and for use in treating cancer.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61P 35/00 - Antineoplastic agents
• G01N 33/573 - Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Abstract

A light emitting device includes a first electrode, a hole transporting layer in contact with the first electrode, a second electrode, an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a metal-assisted delayed fluorescent (MADF) emitter, a fluorescent emitter, and a host, and the MADF emitter harvests electrogenerated excitons and transfers energy to the fluorescent emitter.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 50/13 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers specially adapted for multicolour light emission, e.g. for emitting white light comprising stacked EL layers within one EL unit
• H10K 85/60 - Organic compounds having low molecular weight
• H10K 85/30 - Coordination compounds

Abstract

A system and method for the efficient collection of CO2 is disclosed. The system includes a subsystem having a condenser and a vaporizer, and a plurality of vessels each having a sorbent and configured to transition between gas collection, gas recovery, and heat recovery phases. The gas collection phase includes the sorbent absorbing CO2. The gas recovery phase has N stages, the vessels releasing a product gas and receiving vapor causing captured CO2 to desorb. The first (N−1) gas recovery stages include the vessel coupled to the subsystem at a downstream pressure and a vessel in the heat recovery phase at an upstream pressure. The Nth gas recovery stage includes the vessel coupled to the condenser at the downstream pressure and the vaporizer at the upstream pressure. The heat recovery phase has (N−1) stages, each including the vessel being coupled to a vessel in the gas recovery phase.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of receptors connected to the first surface via one or more linker moieties, wherein the receptors bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the receptors to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the receptors over a duration. Related receptor oscillator array devices, systems and computer readable media are also provided.

IPC Classes  ?

• G01N 33/557 - Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 21/552 - Attenuated total reflection

Abstract

Compositions including a thermosetting polymer network and a mechanophore covalently bonded to the thermosetting polymer network are provided. Substrates including the compositions are provided. In addition, methods of making the compositions and methods of monitoring stress on a substrate comprising the compositions are provided.

IPC Classes  ?

• C08G 59/14 - Polycondensates modified by chemical after-treatment
• C08G 59/50 - Amines
• C08K 5/20 - Carboxylic acid amides
• C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

Abstract

The present disclosure provides compositions and methods related to antiviral therapeutics. In particular, the present disclosure provides a highly modular platform useful for the development and production of multivalent biomolecules capable targeting and neutralizing a virus.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• A61P 31/12 - Antivirals

Abstract

Various embodiments of systems and methods for cross media joint friend and item recommendations are disclosed herein.

IPC Classes  ?

• G06Q 30/0282 - Rating or review of business operators or products
• G06Q 50/00 - Systems or methods specially adapted for specific business sectors, e.g. utilities or tourism
• G06N 5/022 - Knowledge engineering; Knowledge acquisition
• G06N 5/04 - Inference or reasoning models
• G06F 18/2136 - Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods based on sparsity criteria, e.g. with an overcomplete basis

Abstract

A soft continuum robotic module comprises a plurality of inflatable actuators disposed between plates. Via inflation or deflation of one or more of the actuators, the module may extend, contract, twist, bend, and/or exert a grasping force. One or more modules may be combined to form a robotic arm with multiple degrees of freedom.

IPC Classes  ?

• B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
• B25J 18/06 - Arms flexible
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

A device, method, and system for CO2 capture is disclosed. The method includes receiving a process vapor including water and CO2 into a vessel at an intake pressure, the vessel having a desiccant and a CO2 sorbent material. The method includes passing the process vapor through the desiccant and sorbent, the desiccant absorbing the water resulting in a dry vapor, the sorbent absorbing CO2 from the dry vapor resulting in a CO2-lean dry vapor. The method includes discontinuing the process vapor, desorbing the water from the desiccant by at least one of reducing pressure downstream from the desiccant to below the intake pressure and increasing a temperature of the desiccant, desorbing the CO2 from the sorbent by placing the desorbed water in contact with the sorbent, removing the desorbed CO2 through the product outlet as a product stream, and desorbing a remaining water from the desiccant and the sorbent.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/26 - Drying gases or vapours

Abstract

Synthesis of high SFE nanotwinned metallic films with varying distributions of twin widths on a low SFE metallic layer using magnetron sputtering is disclosed. In various embodiments, a method for forming a nanotwinned metal film may include providing a single crystal silicon wafer, etching the single crystal silicon wafer, depositing a silver film onto the single crystal silicon wafer forming a silver buffer layer, and depositing a metallic film onto the silver buffer layer using sputtering at a controlled temperature.

IPC Classes  ?

• C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
• C23C 14/02 - Pretreatment of the material to be coated
• C23C 14/54 - Controlling or regulating the coating process

Abstract

Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

An indicator system comprising permanganate, an organic reducing agent, an acid, and an inorganic perchlorate salt is provided herein. Methods for using the indicator system to monitor the integrity of a biospecimen are also provided. The systems and methods herein may provide easy-to-use, individual aliquot-level thawed-state indicators for indicating biospecimen time-temperature exposure.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts
• G01K 3/02 - Thermometers giving results other than momentary value of temperature giving integrated values
• G01K 3/04 - Thermometers giving results other than momentary value of temperature giving integrated values in respect of time

Abstract

A photocaged DNA nano-tweezer and methods of using said photocaged DNA nano-tweezer are described. In particular, provided herein is a DNA nano-tweezer comprising a hairpin with a single-stranded loop that comprises a first arm and a second arm; and a trigger strand complementary to the single-stranded loop and comprising at least one photocaged residue with a protecting group.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Described herein are systems and methods for a microfluidic immunoassay for in situ mass spectrometry analysis of intracellular protein biomarkers in tissue. In some embodiments, the tissue may comprise human brain tissue. In some embodiments, the protein biomarkers may comprise Aβ species comprising monomers and oligomers of Aβ1-42, Aβ1-40, Aβ1-39, Aβ2-43, or combinations thereof. In some embodiments, the systems and methods may comprise laser capture microdissection (LCM) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 1/28 - Preparing specimens for investigation
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Described herein are systems and methods for the depolymerization of polyethylene-based plastics. In one embodiment, a method is disclosed that comprises combining a polyethylene-based plastic with a solvent in a reactor to generate a plastic solvent mixture, heating the plastic solvent mixture in the reactor, and fractionating the plastic solvent mixture into a gas phase product, a solid phase product, and a liquid phase product. In another embodiment, a system is disclosed that comprises a solvent, and a reactor configured to receive the polyethylene-based plastic and the solvent and convert the polyethylene-based plastic into a gas phase product, a solid phase product, and a liquid phase product, the reactor being configured to operate at a temperature greater than 275° C. and at a pressure greater than 2 megapascals.

IPC Classes  ?

• C10G 1/10 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal from rubber or rubber waste
• C10G 1/00 - Production of liquid hydrocarbon mixtures from oil shale, oil-sand, or non-melting solid carbonaceous or similar materials, e.g. wood, coal
• B01J 6/00 - Calcining; Fusing
• B01D 3/14 - Fractional distillation
• B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• C08J 11/08 - Recovery or working-up of waste materials of polymers without chemical reactions using selective solvents for polymer components

Abstract

Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

Organic light emitting devices (OLEDs) are described, the OLEDs comprising an anode; a cathode; and an organic region, disposed between the anode and the cathode, comprising a first complex and a second complex; wherein when a voltage is applied across the anode and cathode at room temperature, the OLED emits a luminescent radiation that comprises one or more luminescent radiation components resulting from the formation of at least one exciplex; wherein the exciplex is formed by at least one of the following aggregate types: 1) at least one aggregate within the first complex, and at least one aggregate within the second complex; 2) at least one aggregate between the first and the second complex; and 3) both 1 and 2.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

Systems and methods for preparing encapsulant-containing polymer capsules and fibers, as well as the encapsulant-containing polymer capsules and fibers and composites including the same are described. In one example, forming a plurality of encapsulant-containing polymer capsules includes preparing a mixture comprising a polymer, a solvent, an encapsulant, and a polymer that is soluble in the solvent, and removing some of the solvent from the mixture to yield the plurality of polymer capsules. Each polymer capsule include a shell formed of the polymer and contains the encapsulant. In another example, forming a plurality of polymer fibers containing an encapsulant includes providing the mixture to an electrospin apparatus and electrospinning the mixture to yield the plurality polymer fibers, where each polymer fiber defines a hollow core that contains the encapsulant.

IPC Classes  ?

• D01D 5/00 - Formation of filaments, threads, or the like
• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• B01J 13/12 - Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
• D01D 1/02 - Preparation of spinning solutions
• D01D 5/24 - Formation of filaments, threads, or the like with a hollow structure; Spinnerette packs therefor

Abstract

Various embodiments of a variable geometry quadrotor with a compliant frame are disclosed, which adapts to tight spaces and obstacles by way of passive rotation of its arms.

IPC Classes  ?

• B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters

Abstract

Aspects of the disclosure relate to methods and synthetic regulatory systems for more efficient nuclease-mediated homology-directed repair (HDR). In particular, provided herein are methods for more efficient in vivo and in vitro HDR-based gene editing where the methods comprise introducing into a cell a synthetic regulatory system comprising Cas nuclease, guide RNAs (gRNAs) having various lengths and configured to target distinct nucleotide sequences for simultaneous transcriptional repression (or activation) and genome editing via double stranded break and use of a donor nucleic acid molecule as a template for repair.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

burgdorferiburgdorferi proteome that can be used for detection of Lyme disease in patient samples.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/577 - Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
• A61K 31/65 - Tetracyclines
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C12N 15/65 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers

Abstract

A polymer composite includes a polymer substrate, activated carbon, and a carbonate salt. The activated carbon is infused with the carbonate salt. A hybrid composite includes a fibrous mat with activated carbon and potassium carbonate crystals adhered to the fibrous mat. Making a polymer composite includes combining activated carbon with a polymer to yield a mixture, and electrospinning the mixture to yield nanofibers, wherein the carbonate salt is adhered to or embedded in the nanofibers. Capturing carbon dioxide from a quantity of air includes contacting the polymer composite with the quantity of air in the presence of water vapor to yield potassium bicarbonate sorbed on the polymer composite.

IPC Classes  ?

• B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01D 53/62 - Carbon oxides
• B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01D 53/96 - Regeneration, reactivation or recycling of reactants
• B01J 20/30 - Processes for preparing, regenerating or reactivating

Abstract

Provided herein are methods of modulating temperature in detection fields and producing analyte imaging data. In some embodiments, the methods include introducing an incident light toward a second surface of a substrate to induce a plasmonic wave proximal to a first surface of the substrate such that a temperature in a selected heating space within the detection field is substantially uniformly changed to a selected temperature. Additional methods as well as related systems and computer readable media are also provided.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

A user-space emulation framework for heterogeneous system-on-chip (SoC) design is provided. Embodiments described herein propose a portable, Linux-based emulation framework to provide an ecosystem for hardware-software co-design of heterogenous SoCs (e.g., domain-specific SoCs (DSSoCs)) and enable their rapid evaluation during the pre-silicon design phase. This framework holistically targets three key challenges of heterogeneous SoC design: accelerator integration, resource management, and application development. These challenges are addressed via a flexible and lightweight user-space runtime environment that enables easy integration of new accelerators, scheduling heuristics, and user applications, and the utility of each is illustrated through various case studies. A prototype compilation toolchain is introduced that enables automatic mapping of unlabeled C code to heterogeneous SoC platforms. Taken together, this environment offers a unique ecosystem to rapidly perform functional verification and obtain performance and utilization estimates that help accelerate convergence towards a final heterogeneous SoC design.

IPC Classes  ?

• G06F 11/34 - Recording or statistical evaluation of computer activity, e.g. of down time, of input/output operation
• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

The present invention relates to systems and methods for removing oxidized contaminants from water and wastewater using a metal-biofilm, also referred to herein as a bio-metal composite catalyst. In some embodiments, the system comprises a gas-transfer membrane, a hydrogen-gas source, an inoculant comprising a biofilm-forming population of microorganisms, a growth medium comprising at least one nitrate salt and at least one perchlorate salt, and a catalyst precursor medium comprising at least one soluble autocatalytic metal precursor and having a basic pH. Methods of establishing a bio-metal composite catalyst for removing ammunition-related contaminants are also described.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
• B01D 69/08 - Hollow fibre membranes
• C02F 3/10 - Packings; Fillings; Grids

Abstract

An auscultation system comprises an auscultation device comprising a wearable apparatus positionable proximate to a lung, a plurality of audio sensors embedded in the wearable apparatus configured to record lung sounds, wherein the plurality of audio sensors are positioned at locations of the wearable apparatus corresponding to lung auscultation points, and a computing system communicatively connected to the auscultation device, comprising a processor and a non-transitory computer-readable medium with instructions stored thereon, which when executed by a processor, perform steps comprising, establishing a background noise spectrum, recording a lung sound spectrum via the auscultation device for a period of time, calculating a background subtracted lung sound spectrum by subtracting the background noise spectrum from the measured lung sound spectrum, analyzing the background subtracted lung sound spectrum to produce an auscultation result, and providing the auscultation result to a practitioner to assist in providing a diagnosis.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 7/00 - Instruments for auscultation
• A61B 7/04 - Electric stethoscopes

Abstract

A Processing-in-Memory (PIM) design is disclosed that converts any memory sub-array based on non-volatile resistive bit-cells into a potential processing unit. The memory includes the data matrix stored in terms of resistive states of memory cells. Through modifying peripheral circuits, the address decoder receives three addresses and activates three memory rows with resistive bit-cells (i.e., data operands). In this way, three bit-cells are activated in each memory bit-line and sensed simultaneously, leading to different parallel resistive levels at the sense amplifier side. By selecting different reference resistance levels and a modified sense amplifier, a full-set of single-cycle 1-/2-3-input reconfigurable complete Boolean logic and full-adder outputs could be intrinsically readout based on input operand data in the memory array.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one output; Inverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits

Abstract

A wireless multi-channel implantable device. In some embodiments, the system includes: a wireless reception element, for receiving power wirelessly through tissue of a subject; a power management and storage circuit, for storing a portion of the received power; and a control circuit for controlling the delivery of current from the power management and storage circuit to each of a plurality of stimulation electrodes individually, based on a modulation of the received power.

IPC Classes  ?

• A61N 1/378 - Electrical supply
• H02J 50/20 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves

Abstract

The present disclosure relates to methods of inhibiting and/or reducing the severity of a bacterial infection comprising the administration of Platelet Factor 4 (PF4). The bacterial infection can be caused by Gram-negative or Gram-positive bacteria. The bacterial infection can also have progressed to sepsis or peritonitis. In particular implementations, a method of inhibiting and/or reducing the severity of a Staphylococcus aureus infection is described, including a MRSA infection.

IPC Classes  ?

• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

A passive CO2 collection device is disclosed, including a release chamber and a capture structure having at least three straps and a plurality of sorbent disks coupled to and spaced along the straps. The capture structure is movable between collection and release configurations. Each strap has a primary and secondary width, the secondary width smaller than the primary. The collection configuration includes the disks suspended from a movable portion by the straps such that, for each pair of neighboring disks and for each strap, a lower disk is separated from an upper disk by a connecting segment, allowing the sorbent to capture carbon dioxide from an airflow. The release configuration includes the disks being stacked within the chamber for regeneration. Each connecting segment is in a release topology designed to accommodate stacking the disks within the chamber. The connecting segment is biased to move toward the release topology.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%. Providing the electrochemical sensor can include providing at least one member selected from the group consisting of perfluoro-1-octanethiol (PFTO), 2,2,2-trifluoroethanethiol (TFET) or perfluorodecanethiol (PFDT) on the surface of the glassy carbon substrate.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
• G01N 27/42 - Measuring deposition or liberation of materials from an electrolyte; Coulometry, i.e. measuring coulomb-equivalent of material in an electrolyte
• C25D 3/48 - Electroplating; Baths therefor from solutions of gold

Abstract

An additive manufacturing process for forming a metallic layer on the surface of the substrate includes fabricating a substrate from a polymerizable composition by a stereolithographic process, and contacting the reactive surface with an aqueous solution including a metal precursor. The metal precursor includes a metal, and the polymerizable composition includes a multiplicity of multifunctional components. Each multifunctional component includes a reactive moiety extending from a surface of the substrate to form a reactive surface. An interface between the reactive surface and the aqueous solution is selectively irradiated to form nanoparticles including the metal in a desired pattern. The nanoparticles are chemically coupled to the reactive surface by reactive moieties, thereby forming a metallic layer on the surface of the substrate.

IPC Classes  ?

• B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
• B33Y 10/00 - Processes of additive manufacturing
• H05K 1/09 - Use of materials for the metallic pattern
• B22F 1/054 - Nanosized particles
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B22F 10/12 - Formation of a green body by photopolymerisation, e.g. stereolithography [SLA] or digital light processing [DLP]

Abstract

Provided herein are methods of detecting exosomes, including unlabeled exosomes. In some embodiments, the methods include disposing a fluidic sample that comprises a plurality of exosomes in a chamber that is positioned at least partially within a fluidic device in which an inner surface of the chamber comprises a first set of exosome binding moieties that are capable of binding the exosomes. In some embodiments, the methods also include binding a portion of the plurality of exosomes to a portion of the first set of exosome binding moieties to produce surface-bound exosomes, introducing an incident light toward the inner surface of the chamber prior to, concurrent with, and/or after, producing the surface-bound exosomes, and detecting light scattered by the surface-bound exosomes to produce a set of exosome imaging data. Related fluidic devices, systems, and computer readable media are also provided.

IPC Classes  ?

• G01N 21/55 - Specular reflectivity
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Abstract

A transformable Unmanned Aerial Vehicle (UAV), can operate as a coplanar hexacopter or as an omnidirectional multirotor based on different operation modes. The UAV has 100% force efficiency for launching or landing tasks in the coplanar mode. In the omnidirectional mode, the UAV is fully actuated in the air for agile mobility in six degrees of freedom (DOFs). Models and control design are developed to characterize the motion of the transformable UAV. Simulation results are presented to validate the transformable UAV design and the enhanced UAV performance, compared with a fixed structure.

IPC Classes  ?

• B64U 10/16 - Flying platforms with five or more distinct rotor axes, e.g. octocopters
• B64U 30/29 - Constructional aspects of rotors or rotor supports; Arrangements thereof

Abstract

Provided herein are high-throughput, high-quality methods of consecutive in situ hybridization for analysis of the genome and/or transcriptome in an individual cell with single-molecule sensitivity. In particular, provided herein are methods comprising visualizing individual genomic loci or transcripts as single detectable signals (e.g., fluorescent spots) which remain in place during consecutive hybridization. In each cycle of consecutive hybridization, detectably labeled probes hybridize to the probe used in the previous cycle, and also introduce the binding sites for the probe of the following cycle. Through consecutive cycles of probe hybridization, imaging, and signal removal, different genomic loci or RNA species can be identified by unique detectable signal profiles (e.g., fluorescent spots with unique color sequences). The number of varied color sequences increases exponentially with the number of hybridization cycles, which enables the genome or transcriptome-wide analysis.

IPC Classes  ?

• C12Q 1/6841 - In situ hybridisation
• G01N 21/64 - Fluorescence; Phosphorescence
• C12Q 1/6825 - Nucleic acid detection involving sensors

Abstract

Systems and methods herein train weight-agnostic networks in a federated learning setting with orthogonal data distribution. Unlike traditional networks, weight-agnostic networks have a small size and can be trained using neural architecture search. The methods and systems described herein include sharing of a subset of networks between clients to allow federated learning for weight-agnostic networks in which clients do not have samples from all classes.

IPC Classes  ?

• G06N 3/0985 - Hyperparameter optimisation; Meta-learning; Learning-to-learn
• G06N 3/098 - Distributed learning, e.g. federated learning

Abstract

A full-stack neural network obfuscation framework obfuscates a neural network architecture while preserving its functionality with very limited performance overhead. The framework includes obfuscating parameters or “knobs”, including layer branching, layer widening, selective fusion and schedule pruning, that increase the number of operators, reduce/increase the latency, and number of cache and DRAM accesses. In addition, a genetic algorithm-based approach is adopted to orchestrate the combination of obfuscating knobs to achieve the best obfuscating effect on the layer sequence and dimension parameters so that the architecture information cannot be successfully extracted.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

Runtime task scheduling using imitation learning (IL) for heterogenous many-core systems is provided. Domain-specific systems-on-chip (DSSoCs) are recognized as a key approach to narrow down the performance and energy-efficiency gap between custom hardware accelerators and programmable processors. Reaching the full potential of these architectures depends critically on optimally scheduling the applications to available resources at runtime. Existing optimization-based techniques cannot achieve this objective at runtime due to the combinatorial nature of the task scheduling problem. In an exemplary aspect described herein, scheduling is posed as a classification problem, and embodiments propose a hierarchical IL-based scheduler that learns from an Oracle to maximize the performance of multiple domain-specific applications. Extensive evaluations show that the proposed IL-based scheduler approximates an offline Oracle policy with more than 99% accuracy for performance- and energy-based optimization objectives. Furthermore, it achieves almost identical performance to the Oracle with a low runtime overhead and high adaptivity.

IPC Classes  ?

• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt
• G06F 15/80 - Architectures of general purpose stored program computers comprising an array of processing units with common control, e.g. single instruction multiple data processors

Abstract

The disclosure provides a system, compositions, and methods for detecting ovarian cancer cells by photoacoustic flow cytometry.

IPC Classes  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 15/14 - Electro-optical investigation

Abstract

The present disclosure is directed to systems and methods of forming a modular footwear sole. The modular sole includes a midsole layer having a first attachment fixture disposed on at least a portion of the lower surface of the midsole layer. A heel member includes a deformable heel layer that includes a plurality of deformable elements having the same or different mechanical properties. The heel member includes a second attachment fixture that couples to the first attachment fixture. An outsole member includes a deformable outsole layer that includes a plurality of deformable elements having the same or different mechanical properties. The outsole member includes a third attachment fixture that couples to the first attachment fixture. The deformable elements may be selected based on a user's foot pressure map.

IPC Classes  ?

• A43B 13/36 - Easily-exchangeable soles
• A43B 3/24 - Collapsible or convertible
• A43D 86/00 - Machines for assembling soles or heels onto uppers, not provided for in groups , e.g. by welding
• A43B 21/36 - Heels; Top-pieces or top-lifts characterised by their attachment; Securing devices for the attaching means