A method of metallizing a ceramic substrate includes depositing a barrier layer onto the substrate, depositing a tie layer onto the barrier layer, and depositing a metal layer onto the tie layer to metallize the substrate. The barrier layer may include an oxygen rich material, a nitrogen rich material, or a carbon rich material.
A method includes obtaining test criteria for a monitor configured to be attached to a user; obtaining reference data; determining, based on the test criteria and the reference data, a detached state of the monitor. The determining the detached state includes performing a set of tests indicated in the test criteria. The set of tests includes a first test corresponding to a first power consumption by the monitor. A second test is different from the first test, and the second test corresponds to a second power consumption by the monitor. The second power consumption is larger than the first power consumption. The method further includes automatically modifying, in response to the determining the detached state, an operating mode of the monitor.
Disclosed are medical devices with an acceleration sensor for generating acceleration data, at least two electrodes for generating electrocardiogram (ECG) data, a processor, and memory. The memory, which may be a non-transitory computer readable medium, contains computer-executable instructions that, when executed by the processor, causes the processor to perform the following: obtain the acceleration data and the ECG data from a first range of time and a second range of time different from the first range, generate respiration data based on the acceleration data, and determine that the medical device has flipped in orientation during the second range of time by comparing the respiration data and the ECG data of the first range of time with the respiration data and the ECG data of the second range of time.
Systems and methods for managing physiological events generated by a medical device in a patient are discussed. An exemplary system includes a controller circuit to receive information about a plurality of physiological events detected by a medical device in a patient, generate for each of the physiological events a respective feature set using the received information, and cluster the physiological events into different event groups using values of temporal or morphological features of the generated feature sets. The event groups each include a respective set of physiological events. The controller circuit can identify from at least one event group a representative event representing the physiological events of that event group, and output to a user or a process the representative event and an indication that the representative event has been determined and represents the set of physiological events in the even group.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
Systems and methods for detecting and classifying premature ventricular contractions (PVCs) are discussed. An exemplary system includes a sensor circuit to sense a cardiac signal of a subject, and a processor circuit to detect heartbeats from the cardiac signal and detect a PVC under a first detection mode or a different second detection mode. The first detection mode includes identifying a PVC candidate of a particular type using cardiac intervals or signal amplitudes of the detected heartbeats, and classifying the identified PVC candidate as a PVC singleton or a pattern of multiple consecutive PVCs using signal features including morphology features of the sensed cardiac signal. The second detection mode includes detecting PVC of the particular type using the cardiac intervals or the signal amplitudes of the detected heartbeats. The first detection mode can be transitioned to the second detection mode in response to a mode-switching trigger event.
Embodiments herein relate to interactive medical visualization systems for visualizing stimulation lead placements and related methods. In an embodiment, a medical visualization system can be included having a video processing circuit, a central processing circuit in communication with the video processing circuit, and a user interface. The user interface can be generated by the video processing circuit and can include a three-dimensional model. The three-dimensional model can include at least a portion of a subject's anatomy and a graphic representation including at least one cancer therapy stimulation lead, and a visual thermal heating zone associated with the graphic representation of the at least one cancer therapy stimulation lead and/or a visual electrical field strength zone associated with the graphic representation of the at least one cancer therapy stimulation lead. Other embodiments are also included herein.
Systems and methods for detecting a physiological event or estimating a physiological parameter using ambulatory electrograms of a subject are discussed. An exemplary system includes a computing device that can receive ambulatory electrograms collected by an ambulatory medical device (AMD) associated with a subject, and apply the ambulatory electrograms to a trained machine learning model to estimate a physiological parameter or to detect a physiological event in the subject. The same or a different machine learning model can be trained to detect an operating status of the AMD using the ambulatory electrograms. The system comprises an output device to output the estimated physiological parameter, the detected physiological event, or the detected device operating status a user or a process such as to initiate or titrate a therapy.
Systems and methods to predict a patient mortality risk are disclosed, including determining a risk value for a plurality of physiologic measures and determining a mortality risk metric indicative of a risk of patient mortality as a weighted combination of the plurality of physiologic measures having risk values satisfying a pre-determined condition.
Embodiments herein relate to implantable cancer therapy electrodes with reduced magnetic resonance imaging artifacts. In an embodiment, a lead for a cancer treatment system can include a lead body with a proximal end and a distal end and defining a lumen, and one or more electric field generating electrodes, wherein the one or more electric field generating electrodes can be disposed along a length of the lead body. The one or more electric field generating electrodes include a ribbon wire with a thickness of the ribbon wire in a radial direction with respect to the lead body of less than 0.005 inches, or a walled tube with a thickness of the walled tube less than 0.005 inches, or a sputter coating with a thickness of the sputter coating in a radial direction with respect to a lead body of less than 0.005 inches. Other embodiments are also included herein.
Disclosed are medical devices with an acceleration sensor configured to generate acceleration data, a processor, and a memory. The memory, which may be a non-transitory computer readable medium, contains computer-executable instructions that, when executed by the processor, causes the processor to perform the following: obtain the acceleration data from a first range of time and a second range of time different from the first range, generate heart sound data based on the acceleration data, and determine that the medical device has flipped in orientation during the second range of time by comparing the heart sound data obtained during the first range of time with the heart sound data obtained during the second range of time.
Systems and methods for detecting cardiac arrhythmias such as atrial tachyarrhythmia (AT) are discussed. An exemplary system includes an arrhythmia detector circuit that can receive physiologic information sensed from a patient over time, detect an arrhythmia onset when the physiologic information during a first time period satisfies an onset condition, and in response to the detected arrhythmia onset, detect an arrhythmia termination when the physiologic information during a second time period, subsequent to and longer than the first time period, satisfies an exit condition. An arrhythmia episode can be detected based on an arrhythmia duration between the detected onset and termination. The detected sustained arrhythmia episode can be provided to a user or a processor for further processing.
An implantable medical device comprises a hermetically sealed housing including at least a first window configured for wireless transfer of an external power signal therethrough, an antenna disposed within the housing at a position such that the antenna can receive the external power signal through the window, and circuitry disposed within the housing and operatively coupled to the antenna.
Systems and methods are disclosed to determine a measure of patient weight using existing medical device sensors, comprising receiving acceleration information of a patient and, if a value of the acceleration information exceeds an activity threshold over a measurement window, detecting patient steps in the measurement window using the acceleration information, determining a patient step rate over the measurement window using the detected patient steps, determining a measure of patient step force for the measurement window, and determining a measure of patient weight using the determined patient step rate and measure of patient step force.
Embodiments herein relate to rechargeable electrical stimulation-based cancer therapy systems and related methods. In a first aspect, an electrical stimulation-based cancer therapy system is included having an implantable electrical field generator unit including a housing, a header coupled to the housing, and electrical field generation circuitry is disposed within the housing. The system can also include an implantable recharge lead, wherein the implantable recharge lead is removably coupled to the header. The system can also include a plurality of therapy leads, the therapy leads including a plurality of electrodes, wherein the plurality of therapy leads area also removably coupled to the header. The system can also include an external recharger unit. Other embodiments are also included herein.
Embodiments herein relate to integrated thermo-photonic chemical sensors as part of an implantable sensing device. In a first aspect, an implantable sensing device is included having a sensing element, an optical excitation assembly configured to illuminate the sensing element, an optical detection assembly configured to receive optical signals from the sensing element, and a control circuit, wherein the control circuit is configured to receive signals from the optical detection assembly, receive signals reflecting temperature, and process signals from the optical detection assembly while adjusting for the signals reflecting temperature. Other embodiments are also included herein.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1495 - Calibrating or testing in vivo probes
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
16.
ROLLED MULTILAYER CHEMICAL SENSING ELEMENTS AND DEVICES AND SYSTEM INCLUDING THE SAME
Embodiments herein relate to chemical sensing elements including a rolled multilayer structure. In a first aspect, a method of making a chemical sensor element is included, the method including depositing a polymer layer onto a deposition substrate, infusing a chemical sensor composition into the polymer layer, applying a hydrogel layer over the polymer layer to form a multilayer film, rolling the multilayer film down the deposition substrate, and slicing the multilayer film to form the chemical sensor element. Other embodiments are also included herein.
Embodiments of the present disclosure relate to implantable medical device (IMD) enclosures. In an exemplary embodiment, an IMD comprises: a housing comprising an open end and a header defining a cavity and comprising at least one conduit through a wall of the header, wherein the header is formed from a non-conductive material. Further, the IMD comprises a coupling member comprising a flange, wherein the flange is configured to be received by the open end of the housing and wherein the flange and the open end of the housing at least partially overlap along an axial direction of the IMD when the flange is received by the open end. Additionally, the IMD comprises an electrode arranged on an outer surface of the header and a feedthrough coupled to the electrode and extending through the conduit of the header, wherein the feedthrough is configured to be coupled to internal circuity housed within the IMD. Further, the IMD comprises a ring forming a hermetic seal between the coupling member and the header.
Wearable, automatic external, and implantable defibrillators, as well as methods of operation in such systems, are disclosed with shock delivery mitigations to avoid delivering a defibrillation shock on a T-wave. Prior to issuance of a defibrillation shock, one or more detected cardiac events are analyzed to characterize a detected event that is sensed for purposes of synchronizing the defibrillation shock. The detected event can be characterized as an R-wave or a T-wave, and the shock delivery protocol is then selected based on the characterization of the detected event to avoid shock-on-T and potential pro-arrhythmia.
Systems and methods to are disclosed to determine a sleep disordered breathing parameter of a patient, including receiving respiration information of the patient and temperature information of the patient and to determine the sleep disordered breathing parameter of the patient using the received respiration information and temperature information of the patient.
Systems and methods to determine a composite respiratory vibration of a patient are disclosed, including a signal receiver circuit configured to receive physiologic information cyclic with patient respiration and vibration information indicative of patient respiratory vibrations for a plurality of respiratory cycles of a patient, and an assessment circuit configured to identify a first set of respiratory cycles of the plurality of respiratory cycles having a duration within a threshold, align segments of the vibration information corresponding to the first set of respiratory cycles, the segments associated with a desired portion of the respiratory cycle using a feature of the respiratory cycle, and determine the composite respiratory vibration using the aligned segments.
Embodiments herein relate to systems for tracking and maintaining the integrity of patient device data over extended periods of time. In a first aspect, a medical device system is included having an implantable device that can include a control circuit, a communication circuit, and one or more sensors. The system can also include an external device including a control circuit and a communication circuit. The external device can be configured to receive patient data from the implantable device and execute a hashing operation on units of received patient device data and one or more previous digest packets to create new digest packets. The external device can be configured to store the new digest packets and forward digest packets onto another device of the medical device system when requested to allow patient data to be authenticated. Other embodiments are also included herein.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
A61N 1/372 - Arrangements in connection with the implantation of stimulators
Disclosed herein is an implantable medical device including a housing, a header, a connector port, and a collet assembly. The header can be arranged with the housing. The connector port can be arranged within the header and configured to couple an implantable lead to the header. The collet assembly can be arranged within the connector port and configured to frictionally engage a portion of the implantable lead and to secure the implantable lead with the header in response to insertion of the portion of the implantable lead into the connector port.
Systems and methods to couple electrical contacts of a header of a medical device to respective feedthrough pins of a connector block of a medical device housing using a preformed wire are disclosed. The preformed wire can include a proximate portion comprising a number of turns shaped to engage a feedthrough pin. The number of turns of the preformed wire, once engaged with the feedthrough pin, can physically separate a major portion of the preformed wire from the connector block and the housing. The major portion of the preformed wire can be shaped to route a distal portion of the preformed wire to a first electrical contact of the header when the proximate portion of the preformed wire engages the feedthrough pin.
An implantable medical device may include a plurality of electrical components connected to form operational circuitry, a canister shaped for housing the operational circuitry, and a dampening layer configured to reduce internal motion between the operational circuitry and at least one of a plurality of additional component within the canister, the dampening layer selectively disposed over the operational circuitry but not over the at least one additional component, the dampening layer providing electrical isolation to the operational circuitry, the dampening layer comprising a moldable material in direct contact with an inner surface of the canister. Methods of manufacturing such a medical device are also disclosed.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a connector port subassembly for a medical device. The connector port subassembly may include a connector bore arranged within the core subassembly including a proximal end and a distal end; one or more connector blocks arranged within the connector bore; and one or more seal rings moulded to an interior surface of the connector bore and arranged adjacent to the one or more connector blocks.
Systems and methods to detect pneumonia in cardiovascular patients are disclosed, including receiving physiologic information of a patient from an ambulatory medical device (AMD), the physiologic information comprising respiration information of the patient, and determining a pneumonia score of the patient using the received respiration information.
Embodiments of the present disclosure relate to implantable medical devices (IMDs). In an exemplary embodiment, an IMD comprises a power source and a housing enclosing the power source. The housing comprises a first side and a second side extending along a longitudinal axis between a first end and a second end, wherein the first side is opposite the second side and the first end is opposite the second end, and wherein a first distance between the first and second ends is greater than a second distance the first and second sides. The IMD further comprises a printed circuit board arranged on the first side of the base and conductively coupled to the power source. The IMD also comprises a non-conductive enclosure arranged over the printed circuit board and hermetically sealing the printed circuit board, the non-conductive enclosure comprising an outer surface. And, the IMD comprises first and second electrodes arranged on the outer surface of the non-conductive enclosure, wherein the first external electrode is coupled to the printed circuit board by a first trace and the second external electrode is coupled to the printed circuit board by a second trace.
Embodiments of the present disclosure relate to implantable medical devices. According to an exemplary embodiment, a method for forming an electrode on an implantable medical device (IMD), comprises forming a nonconductive body comprising a well having a bottom surface and at least one side surface extending from the bottom surface. The method further comprises forming a conduit through the bottom surface and inserting the nonconductive body into an opening in an external surface of the IMD. The method also comprises depositing conductive material into the well and coupling the conductive material to a circuit of the IMD via the conduit through the bottom surface of the well.
A connector apparatus for a medical device includes a cylindrical core of nonconductive material, a beam of conductive material, and a sleeve of conductive material. The cylindrical core includes an outside surface, an inside surface, a hollow center having a cross sectional area, and a slot opening in the cylindrical core extending from the outside surface to the inside surface. The beam is placed in the slot opening in the cylindrical core, wherein the beam reduces the cross-sectional area of the hollow center of the cylindrical core. The sleeve of conductive material is placed over the outside surface of the cylindrical core.
A61N 1/375 - Constructional arrangements, e.g. casings
H01R 24/58 - Contacts spaced along longitudinal axis of engagement
H01R 24/76 - Two-part coupling devices, or either of their cooperating parts, characterised by their overall structure with sockets, clips or analogous contacts and secured to apparatus or structure, e.g. to a wall
30.
IMPLANTABLE MEDICAL DEVICE HAVING A BIOCOMPATIBLE CIRCUIT BOARD WITH EMBEDDED ELECTRODES
Embodiments of the present disclosure relate to implantable medical devices (IMDs). In an exemplary embodiment, an IMD comprises: a housing including a plurality of feedthroughs extending through the housing, a first electrode, a second electrode, and a biocompatible circuit board disposed around an outer surface of the housing. The biocompatible circuit board comprising a plurality of traces, wherein a first trace of the plurality of traces is coupled to the first electrode and a first feedthrough of the plurality of feedthroughs, and a second trace of the plurality of traces is coupled to the first electrode and a second feedthrough of the plurality of feedthroughs.
A disposable pacemaker comprises a housing including a stylet port, a pulse generator printed circuit board assembly situated in the housing, and a pacing lead secured to the housing. The pacing lead includes a lumen aligned with the stylet port, such that the stylet port and the lumen of the pacing lead are configured to receive a stylet.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include a connector port subassembly. The connector port subassembly may include one or more connector blocks configured to interference fit within a connector bore, one or more windows through the core subassembly to the one or more connector blocks, and one or more seal rings configured to interference fit within the connector bore and eliminate adulterant entry into the connector bore through the one or more windows.
Various aspects of the present disclosure are directed toward apparatuses, systems and methods for connecting a lead to an implantable medical device. The apparatuses, systems and methods may include a clamp arranged within a connector port configured to secure the lead with a header in response to frictional engagement between a portion of the implantable lead and the clamp.
An implantation and/or retrieval device for a leadless cardiac pacing device may include a first elongate shaft including a lumen; a second elongate shaft slidably disposed within the lumen of the first elongate shaft; an end cap assembly fixedly attached to a distal end of the first elongate shaft; and a plurality of wires attached to the second elongate shaft and extending distally from the end cap assembly, the plurality of wires being movable relative to the end cap assembly. The plurality of wires is configured to engage a proximal hub of the leadless cardiac pacing device. The plurality of wires forms a plurality of wire loops extending distally from the end cap assembly.
A system may include a leadless cardiac pacing device including a body, a proximal hub, and a helical fixation member opposite the proximal hub; and a first elongate shaft having a lumen extending from a distal end of the elongate shaft proximally into the elongate shaft and a transverse member extending transversely across the lumen. The proximal hub may include a transverse channel extending into the proximal hub, the transverse channel being configured to engage the transverse member.
Embodiments of the present disclosure relate to detecting implantable medical device orientation changes. In an exemplary embodiment, a medical device having a processor, comprises an acceleration sensor and memory. The acceleration sensor is configured to generate acceleration data that comprises a plurality of acceleration measurements. The memory comprises instructions that when executed by the processor, cause the processor to: obtain the acceleration data from the acceleration sensor; and determine, based on the acceleration data, that the medical device has flipped.
A medical device includes: a case at least a portion of which functions as a first electrode; a second electrode disposed in a header coupled to the case; a core assembly, the core assembly including operational circuitry enclosed within a core assembly housing, wherein the case includes the core assembly housing; and a battery assembly, the battery assembly including a battery enclosed within a battery housing, where the case further comprises the battery housing; where the operational circuitry is configured to drive a regulated voltage onto the case.
A leadless pacing device may include a housing having a proximal end and a distal end, and one or more electrodes supported by the housing. The housing may include a body portion and a header. A distal extension may extend distally from the header of the housing, the distal extension including one or more electrodes. The header may include a guide wire port and a guide wire lumen may extend from the guide wire port through the header of the housing and through the distal extension A fixation member may extend from the header of the housing, wherein the fixation member has a helical configuration in a relaxed state and is configured to be plastically deformed to a straightened configuration in response to an axial retrieval force applied thereto.
A leadless pacing device may include a housing having a proximal end and a distal end, and one or more electrodes supported by the housing. The housing may include a body portion and a header. A distal extension may extend disiaUy from the header of the housing, the distal extension including one or more electrodes. The header may include a guide wire port and a guide wire lumen may extend from the guide wire port through the header of the housing and through the distal extension. A fixation member may extend from the header of the housing. Tire header may he formed from an over mold process.
Systems and methods for assessing a cardiac arrhythmia risk of a patient, such as a risk for developing atrial fibrillation, are disclosed. An exemplary medical-device system includes an arrhythmia predictor circuit configured to receive physiologic information of a patient, and in an absence of atrial tachyarrhythmia in the patient, determine a risk of the patient developing future atrial tachyarrhythmia using the physiologic information. In accordance with the arrhythmia risk indication, the system can generate an alert, or initiate more aggressive monitoring of a patient identified as having a high atrial tachyarrhythmia risk.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
Systems and methods for monitoring and evaluating the function of a prosthetic heart valve (PHV) implanted in a patient are discussed. An exemplary medical-device system can receive heart sounds information including vibrational or acoustic information generated by an implanted PHV, and generate an indicator of function of the PHV using a HS metric of received acceleration information. An alert of PHV dysfunction can be presented to a system user. The PHV function may be monitored during a valve replacement procedure to assist in position adjustment of the prosthetic value, or after the valve replacement procedure to assess patient progress in recovery. According to some embodiments, the system can generate a risk indicator indicating patient natural valve function and a need for heart valve repair or replacement.
Embodiments herein relate to implantable medical devices including a welded joint with reduced residual stress. In a first aspect, an implantable medical device is included having a power subunit comprising a first biocompatible electrically conductive shell, an anode disposed therein, a cathode disposed therein, and a lid. The implantable medical device can further include an electronics control subunit comprising a second biocompatible electrically conductive shell, and a control circuit disposed therein. Both of the first and second biocompatible electrically conductive shells can include first and second opposed wide sides, first and second opposed narrow sides, and four rounded corners. The first shell can be welded to the lid around a perimeter thereof forming a weld line. The weld line can have a weld line terminus and the weld line terminus can be positioned on a narrow side or a rounded corner. Other embodiments are also included herein.
An apparatus includes a housing including a bore and a housing groove within the bore and located on an inner surface of the housing; and a coil spring located within the housing and mounted within the housing groove, wherein the housing groove has a non-uniform radius such that the coil spring defines zones of relative low contact force and zones of relative high contact force.
in vivoin vivo environment. In some embodiments a lithium anode can be disposed within the first biocompatible electrically conductive shell in direct electrical communication with a feedthrough pin, wherein the feedthrough pin is electrically isolated from the first biocompatible electrically conductive shell. A cathode can also be disposed within the first biocompatible electrically conductive shell and can be in direct electrical communication with the first biocompatible electrically conductive shell. The first biocompatible electrically conductive shell has a positive electrical potential. The implantable medical device further includes an electronics control subunit with a control circuit disposed within a second biocompatible electrically conductive shell. Other embodiments are included herein.
An example of a system may include a sensing circuit and an atrial fibrillation (AF) detection circuit. The sensing circuit may be configured to sense a cardiac signal indicative of atrial and ventricular depolarizations. The AF detection circuit may be configured to detect AF using the cardiac signal and may include a detector and a detection enhancer. The detector may be configured to detect the ventricular depolarizations using the cardiac signal, to measure ventricular intervals each between two successively detected ventricular depolarizations, and to detect the AF using the ventricular intervals. The detection enhancer may include a respiratory sinus arrhythmia (RSA) detector configured to detect RSA using the cardiac signal and may be configured to verify each detection of the AF based on whether the RSA is detected.
This document discusses, among other things, systems and methods to determine an indication of heart failure with preserved ejection fraction (HFpEF) of a subject using a determined change in cardiac acceleration information of the subject at exertion relative to cardiac acceleration information of the subject at rest. The system can include a signal receiver circuit configured to receive cardiac acceleration information of a subject and exertion information of the subject, and an assessment circuit configured to determine the change in cardiac acceleration information of the subject at exertion relative to cardiac acceleration information of the subject at rest, and to determine an indication of HFpEF of the subject using the determined change in cardiac acceleration information.
Systems and methods for monitoring and treating patients with heart failure are discussed. The system may receive patient atrioventricular (AV) conduction characteristic under different heart rates or patient conditions. Stimulation parameters including stimulation timing parameters may be stored in a memory. The system may include a stimulation control circuit configured to determine a parameter update schedule indicating a timing at which to update stimulation parameter using patient AV conduction characteristic, and dynamically update at least a portion of the stored set of stimulation parameters at the determined parameter update schedule. For a specified heart rate or heart rate range, a stimulation parameter may be selected from the set of the stimulation parameters for use during cardiac stimulation.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61B 5/0452 - Detecting specific parameters of the electrocardiograph cycle
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Systems and methods for monitoring and treating patients with heart failure are discussed. The system can store in a memory stimulation parameters, including stimulation timing parameters for a plurality of heart rate ranges. The system includes a plurality of timers with respective durations for the plurality of heart rate ranges. A stimulation control circuit can identify a target heart range in which a detected heart rate falls, and measure an atrioventricular (AV) conduction characteristic value in response to the timer for the target heart range being expired at the detected heart rate. The stimulation control circuit can update a stimulation parameter corresponding to the target heart rate range using the measured AV conduction characteristic. The updated stimulation parameter can be used in cardiac stimulation.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61B 5/0452 - Detecting specific parameters of the electrocardiograph cycle
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
Systems and methods for detecting cardiac arrhythmia are discussed. An exemplary arrhythmia detection system can receive physiologic information of the patient, measure a first signal metric using a first portion of the received physiologic information, and determine an arrhythmia detection duration using a comparison between the measured first signal metric and a reference signal metric value. The system includes an arrhythmia detector to detect an AT episode using a second portion of the physiologic information corresponding to the determined arrhythmia detection duration.
Systems and methods for detecting cardiac arrhythmias such as atrial tachyarrhythmia (AT) are discussed. An exemplary system includes a ventricular beat analyzer circuit to detect ventricular beats and assess ventricular activity, such as to evaluate a ventricular rate stability. The system includes an arrhythmia detector circuit to detect respective AT indications in distinct time periods using portions of received physiologic information during the distinct time periods. A control circuit can monitor the ventricular beats on a beat-by-beat basis, in response to the detected ventricular beats satisfying an instability condition, trigger AT detections during the distinct time periods and withhold AT detection in a subsequent time period if no AT is detected in the present time period. An AT characteristic may be generated using the detected AT indications. A therapy may be delivered in accordance with the AT characteristic.
A method for making an insertable or implantable medical device including a lubricous coating on a silicone substrate includes treating the silicone substrate with an atmospheric plasma at about atmospheric pressure, the atmospheric plasma formed from a noble gas; applying a solution directly to the treated silicone substrate, the solution including a thermoplastic polyurethane; and heating the silicone substrate and the applied solution to form the lubricous coating on the silicone substrate.
Various aspects of the present disclosure are directed toward introducer apparatuses, systems, and methods for positioning an implantable medical device within a patient. The introducer may include a housing having a proximal opening and a distal opening and configured to position the implantable medical device adjacent the distal opening prior to ejection and an ejection rod configured to pass through the proximal opening and eject the implantable medical device from the housing through the distal opening of the housing.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for supporting components of an implantable medical device. The apparatuses, systems, and methods may include a first electrode and a second electrode and a scaffold assembly configured to support the first electrode and the second electrode.
Systems, devices, and methods for monitoring and assessing blood glucose level in a patient are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. The physiologic information is correlated to, and different from, a direct glucose level measurement. The system determines a glucose index indicative of an abnormal blood glucose level using the received physiologic information by the two or more physiologic sensors. The system may use the glucose index to initiate or adjust a therapy, or to trigger a glucose sensor, separate from the two or more physiologic sensors, to directly measure blood glucose concentration.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/021 - Measuring pressure in heart or blood vessels
An electrode assembly for the positioning of an electrode of an implantable medical lead includes a housing and an electrode subassembly. The housing includes a proximal end for connecting to the lead and a distal end. The housing defines a housing lumen extending between the proximal end and the distal end. The housing lumen includes internal screw threads extending along at least a portion of the housing lumen. The electrode subassembly is disposed at least partially within the housing lumen. The electrode subassembly includes a needle electrode and a coupler. The needle electrode is disposed coaxially with the longitudinal axis of the housing lumen. The coupler is disposed at a proximal end of the needle electrode. The coupler includes external screw threads engaged with the internal screw threads of the housing lumen such that rotation of the coupler moves the needle electrode along the longitudinal axis of the housing lumen.
A medical device including a hybrid circuitry assembly, a core assembly housing having an inside surface, and a tag/getter assembly. The core assembly housing to enclose the hybrid circuitry assembly, and the tag/getter assembly to be situated adjacent the inside surface of the core assembly housing. The tag/getter assembly including an identification tag and a hydrogen getter.
A61N 1/375 - Constructional arrangements, e.g. casings
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61L 31/18 - Materials at least partially X-ray or laser opaque
H01L 23/26 - Fillings characterised by the material, its physical or chemical properties, or its arrangement within the complete device including materials for absorbing or reacting with moisture or other undesired substances
A battery includes a battery case including a housing having side walls defining a first open end and a second open end, the battery case including a separate top cover to cover the first open end of the housing and a separate bottom cover to cover the second open end of the housing; a first electrode located within the case; a second electrode located within the case; a first terminal coupled to the first electrode and exposed outside the case; and a second terminal coupled to the second electrode and exposed outside the case.
Systems and methods for reconstructing heart sounds from heart sound samples taken under a sub-optimal condition, such as at a low sampling rate, are discussed. An exemplary system receives acceleration information from a patient sensed at a first sampling rate, and generate a heart sound ensemble of portions of acceleration information over multiple cardiac cycles. The system can reconstruct a heart sound segment to have a second sampling rate, higher than the first sampling rate, using the generated heart sound ensemble. A heart sound metric can be generated using the reconstructed heart sound segment, and used for detecting a cardiac event, such as a cardiac arrhythmia episode, or a worsening heart failure event.
Systems, devices, and methods for monitoring and assessing immunotherapy toxicity are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. In response to an immunotherapy such as CAR T-cell therapy, the system determines a toxicity indication using the received physiologic information. A therapy can be initiated or adjusted using the toxicity indication.
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
60.
SYSTEMS AND METHODS FOR PRESENTING PHYSIOLOGIC DATA
Systems and methods for presenting physiologic data to a user are discussed. An exemplary system includes a presentation control circuit configured to generate signal metrics from data subsets of a physiologic signal corresponding to a device-detected presence of a physiologic event. The signal metrics represent characteristics of the physiologic event. The presentation control circuit may determine, from the plurality of data subsets, a target subset of clinical significance, which has the corresponding signal metric satisfying a specific condition. The presentation control circuit may present the recognized target subset over other subsets of the physiologic data. A user may adjudicate the device detection of the physiologic event or adjust device parameters.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A61N 1/08 - Arrangements or circuits for monitoring, protecting, controlling or indicating
A retention device for use with an implantable medical device (IMD) are disclosed. An illustrative retention device may comprise an elongate body including a configured to receive the lead of the IMD. The retention device may also include securing mechanisms coupled to the elongate body and configured to push against tissue of a patient. The securing mechanisms may also include linking elements coupled to the elongate body and a portion of the securing mechanisms.
This document discusses, among other things, systems and methods to determine a blood pressure measurement of a subject, such as a systolic blood pressure of a subject, a diastolic blood pressure of the subject, or both, using received heart sound information and plethysmography information of the subject. The system can include a signal receiver circuit configured to receive the heart sound information and plethysmography information of the subject, and an assessment circuit configured to determine the systolic and diastolic blood pressure of the subject using the received heart sound information and the plethysmography information of the subject.
A61B 5/021 - Measuring pressure in heart or blood vessels
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
Systems and methods for detecting physiologic events in a patient are described herein. An embodiment of a medical system includes a memory circuit to store physiologic event episodes detected and recorded by a medical device. The system includes a control circuit to analyze the stored physiologic event episodes, and determine a presence of a target cardiac event under a plurality of detection settings. Using the determined presence of the target cardiac event from the stored physiologic event episodes, and user adjudication of the stored event episodes, the control circuit may select, from the plurality of detection settings, a detection setting to detect a subsequent target cardiac event. The control circuit may also prioritize the physiologic event episodes for storage in the memory circuit.
Systems and methods for pacing cardiac conductive tissue are described. An embodiment of a medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses to stimulate a His bundle, and a cardiac event detector to detect a His-bundle activity within a time window following an atrial activity. The cardiac event detector may use a cross-chamber blanking, or an adjustable His-bundle sensing threshold, to avoid or reduce over-sensing of far-field atrial activity and inappropriate inhibition of HBP therapy. The electrostimulation circuit may deliver HBP in the presence of the His-bundle activity. The system may further recognize the detected His-bundle activity as either a FFPW or a valid inhibitory event, and deliver or withhold HBP therapy based on the recognition of the His-bundle activity.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
Systems and methods for ambulatory detection of medical events such as cardiac arrhythmia are described herein. An embodiment of an arrhythmia detection system may include a detection criterion circuit that determines a patient-specific detection criterion using a baseline cardiac characteristic when the patient is free of cardiac arrhythmias. The detection criterion circuit generates a patient-specific threshold of a signal metric by adjusting a population-based threshold of the signal metric, where the manner and the amount of adjustment is based on information about patient baseline cardiac characteristic. The arrhythmia detection system detects an arrhythmia episode using a physiologic signal sensed from the patient and the patient-specific arrhythmia detection threshold.
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
A61B 5/042 - Electrodes specially adapted therefor for introducing into the body
A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
A device for the active fixation of an implantable medical lead includes a housing, a tine assembly, an electrode, and a rotatable shaft. The housing includes a proximal end for connecting to the lead and a distal end opposite the proximal end. The housing defines a housing lumen extending between the proximal end and a recess adjacent to the distal end. The tine assembly is disposed within the housing lumen and includes at least one tine configured to self-bias from a linear configuration within the housing to a curved configuration outside of the housing. The electrode assembly is disposed at the distal end of the housing and includes a plurality of electrodes. The rotatable shaft extends through the housing lumen and is configured to engage the tine assembly such that rotation of the shaft transitions the at least one tine between the linear configuration and the curved configuration.
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A coil and delivery device assembly for securing an electrode lead subcutaneously within a patient's body. The combination may include a coil configured to move between a first, linear orientation and a second helical coil orientation, wherein the coil is biased in the second helical coil orientation, and a delivery device including a housing and an actuator, the housing having a channel configured to receive the coil in the first, linear orientation. The actuator is configured to move or push the coil through the channel and out of the housing. The housing may include a recess in a bottom end thereof, configured to at least partially receive an electrode lead and position the coil for deployment around the electrode lead as the coil is moved through the channel and out of the delivery device.
A catheter for delivering a medical electrical lead to a bundle of His from within a right atrium of a heart. The catheter includes a straight portion and a hook portion projecting from a distal end of the straight portion. The hook portion includes a first curved portion, a second curved portion, and a third curved portion. The straight portion and the first curved portion define a plane. The second curved portion extends from a distal end of the first curved portion. The second curved portion curves away from the plane. The third curved portion extends from a distal end of the second curved portion. The third curved portion curves toward the plane. The catheter forms a lumen extending from a proximal end of the straight portion to an opening at a distal end of the third curved portion.
This document discusses, among other things, systems to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, and alternate the first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay. Physiologic information can be received from the patient, and one of the first or second pacing period for delivery to the patient can be determined using the received physiologic information.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
This document discusses, among other things, systems to receive physiologic information from a patient during different first and second pacing periods having respective, different first and second atrioventricular (AV) delays, determine first and second physiologic parameters using respective received physiologic information from the first and second pacing periods, and adjust the first AV delay using the determined first and second physiologic parameters, wherein the second AV delay is longer than the first AV delay.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
This document discusses, among other things, systems to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, to alternate first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, to receive information indicative of patient metabolic demand, and to determine an adjusted pacing-based hypertension therapy parameter using the received information indicative of patient metabolic demand, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
This document discusses, among other things, systems to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, to alternate first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, and to determine an increased pacing rate for the first pacing waveform during the first pacing period using the first AV delay, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
73.
WEARABLE DEVICE TO DISPOSABLE PATCH CONNECTION VIA CONDUCTIVE ADHESIVE
A medical device configured to be adhesively coupled to an external surface of a subject, and to facilitate physiological monitoring of the subject, includes: a first portion having a housing that at least partially encloses an interior chamber and has a grip portion that has a peanut-like shape; and a second portion including a flexible patch configured to facilitate operably coupling the first portion to the subject. The flexible patch includes third and fourth sensor connections configured to operably interface with the first and second sensor connections, respectively; first and second sensing elements; and a flexible circuit assembly configured to electrically couple the third sensor connection to the first sensing element and the fourth sensor connection to the second sensing element. An adhesive assembly is configured to couple the first portion to the second portion, and includes conductive adhesive portions.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
Systems and methods for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses. A sensing circuit senses a physiologic signal, and detect a local His-bundie activation discrete from a pacing artifact of the HBP pulse. A control circuit verifies capture status in response to the HBP pulses. Based on the capture status, the control circuit determines one or more pacing thresholds including a selective HBP threshold representing a threshold strength to capture only the His bundle but not the local myocardium, and a non-selective HBP threshold representing a threshold strength to capture both the His bundle and the local myocardium. The electrostimulation circuit may deliver HBP pulses based on the selective and non-selective HBP thresholds.
This document discusses, among other things, systems and methods to determine an indication of contractility of a heart of a patient using received physiologic information, and to determine blood pressure information of the patient using the heart sound information and the determined indication of contractility of the heart. The system can include an assessment circuit configured to determine an indication of contractility of a heart of the patient using first heart sound (S1) information of the patient, and to determine blood pressure information of the patient using second heart sound (S2) information of the patient and the determined indication of contractility of the heart.
An apparatus comprises a magnetic field detection circuit, a cardiac signal sensing circuit, a memory circuit, a control circuit, and an arrhythmia detection circuit. The cardiac signal sensing circuit generates a cardiac signal representative of cardiac activity of a subject when coupled to sensing electrodes. The control circuit is operatively coupled to the magnetic field detection circuit; the cardiac signal sensing circuit, and the memory circuit. The control circuit stores cardiac signal data determined using the sensed cardiac signal, receives an indication of magnetic field detection by the magnetic field detection circuit, stores data obtained using the sensed cardiac signal during the magnetic field detection, and stores an identifier indicating the magnetic field detection in association with the data. The arrhythmia detection circuit processes the cardiac signal data to detect a cardiac arrhythmia event and confirm the cardiac arrhythmia event according to the magnetic field indication.
Systems and methods for managing cardiac arrhythmias are discussed. A data management system receives a first detection algorithm including a detection criterion for detecting a cardiac arrhythmia. An arrhythmia detector detects arrhythmia episodes from a physiologic signal using a second detection algorithm that is different from and has a higher sensitivity for detecting the cardiac arrhythmia than the first detection algorithm. The arrhythmia detector assigns a detection indicator to each of the detected arrhythmia episodes. The detection indicator indicates a likelihood that the detected arrhythmia episode satisfies the detection criterion of the first detection algorithm. The system prioritizes the detected arrhythmia episodes according to the assigned detection indicators, and outputs the arrhythmia episodes to a user or a process according to the episode prioritization.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
Systems and methods for managing machine-generated alert notifications of medical events detected from one or more patients are described herein. An embodiment of a data management system may receive an adjudication of a medical event episode including an episode characterization. A storage unit stores an association between one or more episode characterizations and corresponding detection algorithms for detecting a medical event having respective episode characterizations. An episode management circuit may detect from a subsequent episode, using the stored association, a medical event having an episode characterization of at least one medical event episode presented for adjudication, and schedule presenting at least a portion of the subsequent episode based on the detection.
A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.
C08G 18/62 - Polymers of compounds having carbon-to-carbon double bonds
C08G 18/76 - Polyisocyanates or polyisothiocyanates cyclic aromatic
C08G 18/12 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
C08G 18/28 - Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
This document discusses, among other things, systems and methods to determine an indication of discharge readiness for a patient using received physiologic information of the patient corresponding to hospitalization of the patient and received physiologic information of the patient corresponding to a time after hospitalization.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
81.
TROUBLESHOOTING SYSTEM FOR REMOTE PATIENT MONITORING
The technology herein relates to a troubleshooting system for remote patient monitoring. A plurality of triggering conditions defines a data transmission error between a sensor and a remote location. A data transmission log is configured to receive characterization data defining each successful data transmission between a communicator and the remote location. An input user interface is configured to receive input from a user and an output user interface is configured to provide notification to a user. Processing circuitry is in communication with the input interface and the output interface, where the processing circuitry is configured to compare each of the triggering conditions to the characterization data to identify a data transmission error. Upon identification of the data transmission error, the processing circuitry causes the output interface to present a query to the user.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
82.
HIS-BUNDLE PACING SYSTEM WITH LEFT-VENTRICULAR PACING
Systems and methods for cardiac pacing are described in this document. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses to capture a His bundle, and LV pacing (LVP) pulses to capture a left ventricle. A sensing circuit may sense a cardiac activity, such as an atrial or an LV cardiac electrical activity. The system includes a control circuit controlling the delivery of HBP and LVP pulses. The HBP and LVP may be delivered concurrently or sequentially. In an example, the LVP pulses may be delivered based on a His-bundle capture status in response to the HBP pulse. The system may adjust one or more His-bundle stimulation parameters based on the His-bundle capture status.
Embodiments of the present disclosure relate to imaging a body part using sounds. In embodiments, a system comprises a motion sensor and a processing device communicatively coupled to the motion sensor. The motion sensor is configured to sense an acceleration wave produced by a sound emitted by a source and generate acceleration measurements in response to sensing the acceleration wave, wherein the source is associated with the body part of a subject. The processing device is configured to receive the acceleration measurements and determine a location of the source using a location of the motion sensor and the acceleration measurements. In addition, the processing device is configured to image the body part of the subject using the determined location of the source and the acceleration measurements.
A ventricular implantable medical device that is configured to detect an atrial timing fiducial from the ventricle. The ventricular implantable medical is configured to deliver a ventricular pacing therapy to the ventricle based on the detected atrial timing fiducial. If the ventricular implantable medical device temporarily fails to detect atrial activity because of noise, posture, patient activity or for any other reason, an atrial implantable medical device may be configured to communicate atrial events to the ventricular implantable medical device and the ventricular implantable medical device may synchronize the ventricular pacing therapy with the atrium activity based on those communications.
A system and method for communication between an IMD and an external reader includes bringing a portion of a patient's body into contact with a device-body contact surface of an external reader. The reader transmits a first transdermal carrier wave from the contact surface into the patient's body, where the first carrier wave includes a request for communication with the IMD. The transdermal carrier waves are electrical conductive waves, optical waves, or acoustic waves. Upon detection of the first carrier wave, the IMD transmits a second transdermal carrier wave including a request for an access key from the reader and the reader replies by transmitting a third transdermal carrier wave including the access key back to the IMD. If the access key is valid, the IMD transmits information by radio frequency (RF) in an RF communication mode or a fourth transdermal carrier wave including data from the IMD.
A medical device system has a medical device interface configured to download data from an implanted medical device. Memory stores electrode location identification rules and display definitions. Each of the display definitions correspond to possible electrode placement locations of the implanted medical device. Processing circuitry is configured to compare the downloaded data from the implanted medical device to the electrode location identification rules to identify one or more actual electrode placement locations of the possible electrode placement locations of the implanted medical device. A user output interface is in communication with the processing circuitry. The processing circuitry is configured to cause the output to display the one or more actual electrode placement locations.
An implantable medical device (IMD) includes a heterogeneous housing configured to receive and store one or more components of the IMD. The housing includes an intrinsically non-conductive and non-magnetic base material and at least one dopant with a property of at least one of electrical conductance and magnetic permeability. The base material and the dopant form a first region of the housing including a first skin depth and a second region of the housing including a second skin depth different than the first skin depth.
A lead less pacing device may include a housing having a proximal end and a distal end, and a set of one or more electrodes supported by the housing. The housing may include a first a distal extension extending distally from the distal end thereof. The distal extension may include a retractable and/or rotatable distal electrode. The distal electrode may be configured to be delivered to and pace at the Bundle of His. The leadless pacing device may be releasably coupled to an expandable anchor mechanism.
A leadless pacing device is disclosed including a housing having a proximal end and a distal end, and a set of one or more electrodes supported by the housing. The housing includes a first distal extension extending distally from the distal end thereof. One or more electrodes are supported by the distal extension. The leadless pacing device is releasably coupled to an expandable anchor mechanism.
Described herein are systems and methods for classifying clinical episodes in order to more accurately generate alerts for those episodes that warrant them. In some embodiments, alerts are only generated for those episodes that are new or different from previous episodes, where the previous episodes have been found to be not significant enough to warrant an alert.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Systems and methods for detecting slow and persistent rhythms, such as indicative of ventricular response to atrial tachyarrhythmia (AT), are described herein. An arrhythmia detection system monitors patient ventricular heart rate, and identifies slow heart beats with corresponding heart rates falling below a rate threshold during a detection period. The system identifies one or more sustained slow beat (SSB) sequences each including two or more slow heart beats. The system determines a first prevalence indicator of the identified slow heart beats, and a second prevalence indicator of the identified SSB sequences during the detection period. An arrhythmia detector circuit detects a slow and persistent rhythm using the first and second prevalence indicators.
METHODS AND SYSTEMS FOR DETECTING ATRIAL CONTRACTION TIMING FIDUCIALS AND DETERMINING A CARDIAC INTERVAL FROM A VENTRICULARLY IMPLANTED LEADLESS CARDIAC PACEMAKER
A veiitricularlv implantable medical device that includes a sensing module that is configured to gather information during a cardiac cycle and to identify a cardiac interval based at least on part on the gathered information. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified cardiac interval.
A61N 1/375 - Constructional arrangements, e.g. casings
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
93.
METHODS AND SYSTEMS FOR DETECTING ATRIAL CONTRACTION TIMING FIDUCIALS DURING VENTRICULAR FILLING FROM A VENTRICULARLY IMPLANTED LEADLESS CARDIAC PACEMAKER
A ventricularly implantable medical device that includes a sensing module that is configured to detect an artifact during ventricular filling and to identify an atrial event based at least on part on the detected artifact. Control circuitry of the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified atrial event.
A ventricularly implantable medical device that includes a sensing module that is configured to detect an atrial fiducial and identify an atrial contraction based at least on part on the detected atrial fiducial. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart based at least in part on the identified atrial contraction, and can automatically switch or revert the ventricular pacing therapies on the fly.
A ventricularly implantable medical device that includes a sensing module that is configured to identify a search window of time within a cardiac cycle to search for an atrial artifact. Control circuitry in the ventricular implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on an atrial event identified in the search window of time.
Systems and methods for pacing cardiac conductive tissue are described. A medical system includes electrostimulation circuit that may generate His-bundle pacing (HBP) pulses for delivery at or near the His bundle. A capture verification circuit may detect, from a far-field signal representing ventricular response to the HBP pulses, a His-bundle response representative of excitation of the His bundle directly resulting from the HBP pulses, and a myocardial response representative of excitation of the myocardium directly resulting from the HBP pulses. A control circuit may adjust one or more stimulation parameters based on the His-bundle response and myocardial response. The electrostimulation circuit may generate and deliver the HBP pulses according to the adjusted stimulation parameters to excite the His bundle.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
97.
SYSTEM FOR RECOGNITION OF HIS-BUNDLE PACING CAPTURE
Systems for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit that may generate His- bundle pacing (HBP) pulses for delivery at or near the His bundle. In response to the delivery of the HBP pulse, the system senses a near-field cardiac activity representative of excitation of a para-Hisian myocardial tissue, and a far-field cardiac activity representative of excitation of the His bundle and a ventricle. The system classifies a tissue response to HBP into one of a plurality of capture types based on the sensed near-field and far-field cardiac activities. The system includes a control circuit to adjust one or more stimulation parameters based on the classified capture type. The electrostimulation circuit generates and delivers the HBP pulses according to the adjusted stimulation parameters to excite the His bundle.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
Systems and methods for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses for delivery at or near a His bundle of the heart. A control circuit may time the delivery of the HBP pulses within a tissue refractory period subsequent to an intrinsic His-bundle activation of a first His-bundle portion. Based on an evoked His-bundle activation of a second His-bundle portion, the system may determine whether correction of intra-Hisian block has occurred. The system additionally includes a threshold test circuit to determine an individualized pacing threshold representing minimal energy to excite the His bundle and to correct the cardiac conduction abnormality.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
99.
ELECTRIC FIELD SHAPING LEADS FOR TREATMENT OF CANCER
Embodiments herein relate to medical devices including electric field shaping leads and methods for using the same to treat cancerous tumors within a bodily tissue. In an embodiment, an implantable lead for a cancer treatment system is disclosed. The lead can include a lead body having a proximal end and a distal end, where the lead body can define a lumen. The lead can also include a paddle disposed at the distal end of the lead body, the paddle having a width that is greater than a width of the lead body. The paddle can include one or more electrodes disposed on the paddle and one or more electrical conductors disposed within the lumen of the lead body to provide electrical communication between the one or more electrodes and the proximal end of the lead body. Other embodiments are also included herein.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
100.
VOLUME-FILLING LEADS FOR TREATMENT OF CANCER WITH ELECTRIC FIELDS
Embodiments herein relate to medical devices including volume filling leads and methods of use to treat cancerous tumors within a bodily tissue. In an embodiment, a lead for a cancer treatment system is described. The lead can include a lead body having a proximal end and a distal end, where the lead body can define a lumen. The lead can include an expandable lead head connected to the distal end of the lead body, where the lead head can be configured to be expanded between a first non-expanded position and a second expanded position in order to fill an intracorporeal void. The lead can include two or more electrodes disposed on an outer surface of the lead head and two or more electrical conductors configured to provide electrical communication between the two or more electrodes and the proximal end of the lead body. Other embodiments are also included herein.