This disclosure relates to new multi-modal sensing array architectures that can sense normal and shear forces. Examples include resistive sensing arrays that are used to measure changes in the environment and manufacturing processes to produce multi-modal sensing arrays in a highly-automated and inexpensive fashion. Specifically, a manufacturing process includes a cutting operation and sewing/embroidery technique that creates a fully automated process to produce a resistive sensing array. The new manufacturing process enables the reduction of processing time and materials to produce a functioning sensor without limiting the designs space of achievable sensor geometries. Also presented are sensor reading methodologies for high-speed reading that are capable of sensing vibrations and a wide range of forces. Examples include the use of the new sensor arrays in wearable devices.
G06F 3/045 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means using resistive elements, e.g. a single continuous surface or two parallel surfaces put in contact
G01L 1/20 - Measuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress
G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
2.
NANO-PHASE SEPARATING NI POWDER AND THE METHODOLOGY TO IDENTIFY THEM
A method of forming nonplanar nanostructures on a substrate is disclosed. The method includes treating a portion of the surface of the substrate so as to affect its properties. A film is then applied to the substrate after the surface engineering has been completed. Energy is then applied to the film, causing it to delaminate in the regions where the surface was treated, thereby creating the nonplanar nanostructures. The surface treatment may include the application of a self-assembled molecular (SAM) layer, which includes an anchoring group that allows assembly on the surface of the substrate, and also has a functional group that has the desired interaction with the film. The nonplanar nanostructures may be used to form nanoswitches, resonators, and strain engineered surfaces.
B32B 3/08 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by features of form at particular places, e.g. in edge regions characterised by added members at particular parts
B32B 3/10 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material
B32B 3/18 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material characterised by an internal layer formed of separate pieces of material
B32B 1/06 - Layered products essentially having a general shape other than plane characterised by fillings or added members in hollow portions
4.
GUESSING RANDOM ADDITIVE NOISE DECODING (GRAND) WITH QUANTISED SOFT DECISION INFORMATION
We disclose a soft-detection variant of Guessing Random Additive Noise Decoding (GRAND) called discretized soft-information for GRAND (DSGRAND) that can efficiently decode any moderate redundancy block-code in an algorithm that is suitable for highly parallelized implementation in hardware. DSGRAND provides near maximum likelihood decoding performance when provided with five or more bits of soft information per received bit, by discretizing the soft information into noise effect sequences and allocating those sequences into bins according to weight. The use of these bins provides a separate, simplified manner of sequencing noise guessing.
The disclosure provides, in various embodiments, methods of treating fungal infections in subjects in need thereof, methods of attenuating virulence of fungi (e.g., in subjects in need thereof), and methods of inhibiting formation of fungal biofilms on surfaces (e.g., living or inert surfaces) with mucin glycans, tautomer, stereoisomer and/or pharmaceutically acceptable salts thereof. The disclosure further provides, in various embodiments, mucin glycan compositions, such as synthetic mucin glycans and defined mucin glycan compositions.
e.g.e.g., e.g., mRNA vaccines). In still further embodiments, the disclosure provides methods and compositions for enhancing one or more vaccines, such as SARS- CoV-2 mRNA vaccines.
The gastrointestinal capsule provides mechanical stimulation within the gastrointestinal tract. The capsule may be deployed in a subject's gastrointestinal tract orally by the subject ingesting the capsule. The capsule may mechanically stimulate any desired region within the gastrointestinal tract, including the stomach, small intestine, and large intestine. The mechanical stimulations provided by the capsule are applied to a portion of the inner walls or lining of a section of the gastrointestinal tract to simulate satiety.
A61H 1/00 - Apparatus for passive exercising; Vibrating apparatus; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
An ingestible capsule includes a housing forming a cavity and having a textured outer surface. The textured outer surface forms a helical depression and a plurality of protruding studs disposed in the helical depression. The capsule further includes a therapeutic agent disposed in or on the housing. The capsule also includes a biodegradable coating on the textured outer surface of the housing, the biodegradable coating configured to dissolve in a fluid having a pH of 1.5 to 9.
A61H 1/00 - Apparatus for passive exercising; Vibrating apparatus; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
9.
HEMOSTATIC NANOPARTICLES FOR THE TREATMENT OF NON-COMPRESSIBLE HEMORRHAGE AND INTERNAL BLEEDING
An injectable nanoparticular formulation and method of use thereof for treating non-compressible hemorrhage or internal bleeding has been developed. The formulation includes two interactive components, one a targeting nanoparticle with a polypeptide sequence that binds to a cell present at a site of injury, and the other a crosslinking nanoparticle with a bioorthogonal click-crosslinking group.
Several new techniques for designing nanophotonic scintillators which lead to optimal performance and novel functionalities. Important design concepts include the use of absorbing structures inspired by solar cells, angularly-selective structures, and metasurfaces. Scintillators based on conventionally overlooked materials (such as GaAs or GaN) are also disclosed, which are designed to reach efficiencies comparable or superior to state-of-the-art conventional scintillators (such as YAG:Ce and LYSO). Such scintillators provide important enhancement of scintillation yield arising from incorporation of nanophotonic patterns. Additionally, nanophotonic scintillators designed in conjunction with image post processing algorithms (such as deconvolution algorithms, tomographic reconstruction, etc.) are disclosed. These scintillators are designed in order to increase robustness, minimize the required dose/scan time or even the number of scans required in scintillation imaging. These new designs optimize the scintillator for optimal reconstruction.
Composite materials with few or no void defects are described. The composites can include nanoporous network materials. Methods and systems for the fabrication of the composite materials are generally described. According to certain embodiments, composite materials are fabricated without the use of an autoclave or low pressure environments.
B32B 5/06 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments characterised by a fibrous layer needled to another layer, e.g. of fibres, of paper
12.
SYSTEM AND METHOD FOR REAL-TIME DETERMINATION OF PARTICLE SIZE DISTRIBUTIONS IN DRY POWDERS
A method of monitoring a particle size distribution (PSD) is provided. A plurality of particles having a particle size distribution (PSD) may be illuminated by an at least partially coherent beam to produce scattered light. The scattered light may be captured by a pixelated photoelectric detector, thereby creating an ensemble of raw speckled images. Based on the ensemble of the raw speckled images, an ensemble-averaged intensity correlation may be computed. The ensemble-averaged intensity correlation may be provided to an inverse module. The inverse module may be configured to determine the PSD based on the ensemble-averaged intensity correlation. The particle size distribution may be obtained from the inverse module.
A method of monitoring a particle size distribution (PSD) is provided. At least a partially coherent pupil-engineered beam may be produced. A plurality of particles having a particle size distribution (PSD) may be illuminated by the pupil-engineered beam to produce scattered light. The scattered light may be captured by a pixelated photoelectric detector, thereby creating a raw speckled image. An intensity correlation of the raw speckled image may be computed. The intensity correlation may be provided to an inverse module. The inverse module may be configured to determine the PSD based on the intensity correlation. The PSD may be obtained from the inverse module.
6.250.2532126.250.253212 12 in water, and decomposing droplets by passing through a co-flow burner. Also disclosed is a method of produce producing a thin-tape comprising Al-LLZO.
Methods of synthesis of nickel-rich cathode materials can include preheating droplets, decomposing the droplets in a burner, collecting solid particles, and calcinating the solid particles.
A method of synthesis of single crystal nickel-rich cathode materials can include preparing a precursor solution by dissolving lithium nitrate, nickel nitrate, manganese nitrate, and cobalt nitrate in water, aerosolizing the solution of a) in a stream of air using an ultrasonic sprayer, preheating the resulting droplets, premixing the droplets with methane, decomposing the droplets by passing through a co-flow burner, depositing solid particles on a filter, and calcinating the solid particles in a furnace in oxygen to produce a single crystal cathode material.
Engineered or non-naturally occurring systems and compositions comprising novel Type V Cas polypeptides and orthologs thereof are disclosed herein. Also provided are methods of use for the novel Type V Cas polypeptide systems and compositions for reprogrammable targeting of nucleic acid and polynucleotide components.
18.
ADHESIVE BONDING FOR BIFACIAL AND TANDEM SOLAR CELLS
Disclosed herein are solar cells including a perovskite material and at least one adhesive layer, and methods of making the same. The methods provide solar cells in which transparent conductive oxide(s) have been annealed, and in which the perovskite material is not exposed to elevated temperatures which could degrade its performance.
A61Q 17/00 - Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Systems and methods for active and passive suppression of the transition from laminar to turbulent fluid flow in conduits for fluid transport, which include pipes, channels, and semi-confined passageways. Examples include implementations of a turbulence model that predicts a turbulence transition mode of a fluid within the conduit and systems and methods for modifying the fluid in the conduit to reduce or suppress the predicted turbulence transition mode and thereby prevent or delay transition of the fluid flow from laminar to turbulent. Examples include active and systems to introduce disturbances into the fluid flow that cancel, absorb, or reduce the predicted turbulence transition mode. Examples include conduit liners configured to absorb energy from the fluid flow at a frequency of the predicted turbulence transition mode. Examples include textures and surface geometries configured to transfer energy in the fluid flow from the predicted turbulence transition mode to a different frequency.
The present disclosure addresses the aforementioned drawbacks by providing systems and methods for securing electronic devices directly on-person in a way that facilitates extended wearing, while properly positioning the electronic device(s) for effective, extended, data gathering. In particular, an elastomer membrane may be utilized and coupled to the electronic device. An electronically-communicable or transmissible material may be arranged within the elastomer membrane. A bioadhesive layer may be coupled to the elastomer membrane on a side opposite to the electronic device and configured to couple the elastomer membrane to the subject.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 5/259 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
A61B 5/257 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes
Systems, articles, and methods directed to electrochemical systems (e.g., batteries) and the electrochemical reduction of halogenated compounds are generally described. In certain embodiments, the halogenated compound comprises at least one sulfur pentahalide (e.g., pentafluoride) group associated with a conjugated system.
H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
H01M 10/0567 - Liquid materials characterised by the additives
H01M 12/06 - Hybrid cells; Manufacture thereof composed of a half-cell of the fuel-cell type and of a half-cell of the primary-cell type with one metallic and one gaseous electrode
The present disclosure provides a method of editing a genome in a cell including exposing the cell to an engineered Cas nuclease comprising one or more mutations within the DNA binding cleft of the Cas nuclease, wherein exposure to the engineered Cas nuclease decreases, inhibits, or prevents non-homologous end joining (NHEJ) in the cell, and wherein exposure to the engineered Cas nuclease increases one or more homology-driven repair pathways within the cell. The mutant Cas nuclease is also disclosed herein.
A solar cell can include a first transparent conductive oxide (TCO) layer proximate to a first charge transport layer; a second TCO layer proximate to a second charge transport layer; a perovskite layer disposed between first and second charge transport layers; a first plurality of electrically conductive lines disposed between the first TCO layer and the first charge transport layer; and/or a second plurality of electrically conductive lines disposed between the second TCO layer and second charge transport layer.
26.
SYSTEMS, COMPOSITIONS AND METHODS FOR METAL OXYNITRIDE DEPOSITION USING HIGH-BASE PRESSURE REACTIVE SPUTTERING
Systems, compositions, and methods for using reactive magnetron sputtering to encapsulate nanowire networks to improve their chemical, thermal, and electrical stability while maintaining transparency are disclosed. For example, oxynitride films are deposited onto silver nanowire networks using full-metal targets without imparting oxidative damage onto the nanowires. The oxynitrides can be deposited using residual water vapor in the chamber that can take advantage of relatively poor vacuum conditions, which would be compatible with high-volume roll-to-roll sputtering approaches, and would also reduce the cost of encapsulating sensitive metal nanostructures which would encounter high temperatures, currents, or humidity. The resulting films can be applicable in a wide variety of fields as transparent encapsulants, where metal nanostructures would need to be protected from harsh environmental conditions and/or high temperatures - including but not limited to: solar cell electrodes, transparent heaters, touch screens, and LEDs.
Aspects of the disclosure relate to non-naturally occurring constructs for the activation of Shank3 gene expression, AAV vectors comprising the constructs, and gene therapy methods
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/00 - Drugs for disorders of the nervous system
28.
PANCREATIC DUCTAL ADENOCARCINOMA SIGNATURES AND USES THEREOF
Described herein are pancreatic ductal adenocarcinoma (PDAC) signatures and methods of detecting the same in a sample from a subject. Also described herein, are methods of methods of diagnosing, prognosing, and/or treating PDAC in a subject that can include detecting one or more of the PDAC signatures.
This disclosure is directed to a targeted delivery vehicle that can deliver a cargo to a cell of interest. The targeted delivery vehicle has a fusogen and a targeting domain which are embedded in a lipid bilayer membrane that forms a vesicle, and a cargo within the vesicle. The disclosure is also directed to methods for targeted delivery of cargo using the targeted delivery vehicle described herein.
C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A terahertz imaging system is disclosed. The terahertz imaging system includes a terahertz antenna array, made up of a plurality of antenna elements. Each antenna element includes a patch antenna, a one bit phase shifter, and a plurality of storage elements. The storage elements are used to store a plurality of phase states that are supplied to the one bit phase shifter. The one bit phase shifter is configured to either shift the phase of the incoming signal by 90 or 270, depending on the value of the phase state. The one bit phase shifter is also bidirectional, allowing it to phase shift transmitted signals and reflected signals. A plurality of these antenna elements are disposed in a semiconductor device, where the top metal layer is exposed. This top metal layer is used to create the patch antennas.
H01Q 21/26 - Turnstile or like antennas comprising arrangements of three or more elongated elements disposed radially and symmetrically in a horizontal plane about a common centre
H01Q 3/24 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the orientation by switching energy from one active radiating element to another, e.g. for beam switching
H01Q 3/28 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the amplitude
H01Q 3/30 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase
H01Q 19/10 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces
H01Q 21/22 - Antenna units of the array energised non-uniformly in amplitude or phase, e.g. tapered array or binomial array
31.
DEGASSING OF NANO-PHASE SEPARATING POWDERS IN A HYDROGEN CONTAINING ATMOSPHERE
Removal of gas-evolving species from powders can be achieved before sintering occurs, reducing or eliminating gas evolution in a dense body that can lead to swelling, or lowering of density.
A method and apparatus used in preparing a recrystallized metal alloy involve a cooling medium and a heating element to create a cold zone and a hot zone. An additively manufactured metal alloy preform is drawn in a draw direction from the cold zone towards the hot zone to form the recrystallized metal alloy. The cold zone and the hot zone create a surface temperature gradient on at least a portion of the preform of at least about 104K m-1. The step of drawing causes an average grain size of at least a portion of the preform to increase in a direction parallel to the draw direction.
B22F 5/04 - Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of turbine blades
C22C 19/07 - Alloys based on nickel or cobalt based on cobalt
C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
33.
CELL-TYPE SPECIFIC TARGETING CONTRACTILE INJECTION SYSTEM
The present disclosure relates generally to the field of delivery systems using contractile injection systems (CIS). Specifically disclosed are engineered extracellular CISs (eCISs) that can deliver non-natural protein payloads to non-natural target cells such as human cells. In addition, methods of using the engineered eCISs are also disclosed.
An effective amount of one or more microtubule polymerization inhibitors is administered in combination with one or more polo-like kinase (Plk) inhibitors for treating cancer. Administration of the combination of the active agents can be effective to reduce cancer cell proliferation or viability in a subject with cancer to the same degree, or a greater degree, than administering to the subject the same amount of either active agent alone. The active agents can be administered together or separately. Methods of selecting and treating subjects with cancers are also provided.
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/535 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
The introduction of low levels of cleavable comonomer additives into existing vinyl polymerization processes may facilitate the production of chemically deconstructable and recyclable variants with otherwise equivalent properties. The present disclosure describes cleavable comonomer approach as a viable strategy toward circular vinyl polymers. The present disclosure describes copolymers comprising ml instances of the first repeating unit of Formula (i); m2 instances of the second repeating unit of Formula (ii-A) or (ii-B); and optionally one or more types of additional repeating units. The disclosure also provides compounds of the formula:, or a tautomer or salt thereof. The present disclosure further describes methods of preparation, compositions, and kits.
B32B 27/06 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance
B32B 27/24 - Layered products essentially comprising synthetic resin characterised by the use of special additives using solvents or swelling agents
B32B 27/28 - Layered products essentially comprising synthetic resin comprising copolymers of synthetic resins not wholly covered by any one of the following subgroups
B32B 27/04 - Layered products essentially comprising synthetic resin as impregnant, bonding, or embedding substance
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
Methods involving physics-informed deep learning to help solve inverse problems of solid materials/structures related to unknown geometry include (1) identifying and characterizing unknown materials/structures and defects with accuracy and predictive capability and limited non-destructive measurements, and/or (2) designing geometrical features and parameters of solid materials and structures to achieve optimized and/or improved performance.
B29C 64/386 - Data acquisition or data processing for additive manufacturing
B33Y 50/00 - Data acquisition or data processing for additive manufacturing
G01B 11/16 - Measuring arrangements characterised by the use of optical techniques for measuring the deformation in a solid, e.g. optical strain gauge
G01B 21/32 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring the deformation in a solid
B81C 99/00 - Subject matter not provided for in other groups of this subclass
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (USA)
Inventor
Lang, Jeffrey H.
Yeiser, Aaron J.
Nakajima, Hideko Heidi
Kymissis, Ioannis
Olson, Elizabeth
Mchugh, Christopher I.
Graf, Lukas
Abstract
A piezoelectric sensor and amplifier for use with an auditory aid device are disclosed. The piezoelectric sensor includes a top sensor and a bottom sensor disposed on opposite surfaces of a flex printed circuit board. The top and bottom sensors are made of a piezoelectric material, such as PVDF. Further, the piezoelectric sensor is adapted to be implanted into a subject's ear, where the piezoelectric sensor is cantilevered with the free, or distal end, touching the umbo. The proximal end is held in place by a support that is affixed to the ear. Additionally, the piezoelectric sensor is shaped so that the width of the distal end is less than the width at the proximal end. Further, the piezoelectric sensor generates differential signals, which are then amplified using a differential amplifier circuit.
H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
41.
AN IMPLANTABLE CLOSED-LOOP SYSTEM FOR MONITORING AND TREATMENT
A device configured to be implanted in a subject includes a sensing module, a therapeutic module, and a battery. The sensing module includes at least two of an accelerometer, an electrocardiogram (ECG) sensor, a photoplethysmogram (PPG) sensor, and a temperature sensor. The therapeutic module includes a drug reservoir and a reciprocating pump. The battery powers the sensing module and the therapeutic module. The sensing module is configured to detect a biological event in the subject and, upon detection of the biological event, send a signal to the therapeutic module. The therapeutic module is configured to receive the signal from the sensing module and, upon receiving the signal, administer a drug to the subject from the drug reservoir via the pump.
C12P 23/00 - Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Xu, Qian
Chen, Gang
Liu, Weishu
Deng, Biao
Zhang, Pengxiang
Abstract
The present disclosure generally relates to high-performance flexible thermoelectric generators (f-TEGs) for heat concentration and dissipation. In some embodiments, the f-TEGs can be incorporated into wearable devices. The f-TEG device can include an f-TEG network of thermoelectric units that include multifunctional thin copper disks that can be used as electrodes, heat concentrators and spreaders, spacers, and flexibility enablers. Each electrode can include a spacer extending therefrom to suppress the heat loss between the hot and the cold sides through conduction and convection across a thermoelectric pillar disposed therebetween. In some embodiments, the f-TEG network can be associated with a fabric to provide good wearability and comfort even in wet thermal environments.
H10N 10/17 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the structure or configuration of the cell or thermocouple forming the device
H10N 10/13 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the heat-exchanging means at the junction
45.
SYSTEM AND METHOD FOR A FLEXIBLE PRESSURE SENSOR FOR GASTROINTESTINAL MANOMETRY
A system for assessing a pressure profile of a gastrointestinal (GI) tract is provided. The system includes a flexible tube defining a first lumen and an electrically-conductive liquid contained within the first lumen. At least one restriction is restriction formed on the flexible tube to constrict but not completely occlude the first lumen. The system further includes a sensor system configured to monitor an electrical property of the electrically-conductive fluid over time and to generate a report of pressure changes in the GI tract by correlating changes in the electrical property with the pressure changes in the GI tract.
A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
Disclosed herein are modified mRNAs with poly(A) tails containing one or more additional poly- A tails or 5' caps, which may be made by ligation of nucleic acids onto the 3' terminal end or 5' terminal end of an RNA, respectively. Also provided are compositions comprising one or more modified mRNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.
Some aspects relate to a toroidal field (TF) coil for a tokamak. The TF coil includes a first inner leg having teeth on a side of the first inner leg. The corresponds to an interface between the TF coil and a second TF coil. The teeth extend along a direction having a component in a radial direction of the tokamak. The teeth are configured to mechanically engage with second teeth of a second inner leg of the second TF coil.
C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
C12N 15/65 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
FF = 0 clock state. A pair of neutral atoms of the plurality of neutral atoms is entangled by directing a laser pulse thereto. The laser pulse is configured to transition the pair of neutral atoms through a Rydberg state. The optical trap corresponding to at least one neutral atom of the pair is adiabatically moved, thereby moving one atom of the pair relative to the other atom of the pair without destroying entanglement of the pair.
Provided herein are lipid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a tissue or cell in a subject (e.g., a liver, lung, or spleen tissue/cell).
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C07C 237/00 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
C07D 211/14 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C07D 233/61 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
C07D 243/08 - Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
51.
COMPOSITIONS AND METHODS FOR DELIVERING CARGO TO A TARGET CELL
Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more LTR retroelement polypeptides for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more LTR retroelement polypeptides for forming a delivery vesicle may comprise two or more of an LTR retroelement gag protein, a retroelement envelope protein, an LTR retroelement reverse transcriptase, or a combination thereof. The LTR retroelement polypeptide alone, the LTR retroelement envelope protein alone, or both the LTR retroelement-derived polypeptide and LTR retroelement envelope protein may be endogenous.
The present invention relates to a composition comprising a polyimidazolium (PIM) compound for use in the treatment and/or prevention of mastistis in a mammal, and to methods of use.
Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more LTR retroelement polypeptides for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more LTR retroelement polypeptides for forming a delivery vesicle may comprise two or more of an LTR retroelement gag protein, a retroelement envelope protein, an LTR retroelement reverse transcriptase, or a combination thereof. The LTR retroelement polypeptide alone, the LTR retroelement envelope protein alone, or both the LTR retroelement-derived polypeptide and LTR retroelement envelope protein may be endogenous. In some embodiments the LTR- retroelement-derived polypeptide is a PNMA polypeptide.
A sequentially stacked multi-stage desalination system includes a single pair of electrodes, including an anode and a cathode; at least one ion concentration polarization device; and at least one electrodialysis device coupled with the ion concentration polarization device and configured to receive liquid flow from the ion concentration polarization device. Each ion concentration device and electrodialysis device is positioned between the anode and the cathode.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
A device is configured to be administered via an oral route by a subject. The device includes an anode, a seal disposed on the anode, and a cathode. When exposed to a liquid or a hydrogel, an exposed surface of the anode undergoes galvanic oxidation dissolution to provide DC power to the device. As the exposed surface of the anode undergoes galvanic oxidation dissolution, the seal incrementally detaches from the anode, and a substantially constant surface area of the exposed surface is maintained.
Disclosed herein are compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof. Also disclosed herein are methods of making and methods of use of the compounds, compositions, and/or lipid particles disclosed herein. For example, the compounds and compositions are useful for treating a disease or disorder in humans and in animals. In some examples, the subject is a human male and the disease or disorder comprises male infertility.
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61P 15/10 - Drugs for genital or sexual disorders; Contraceptives for impotence
Apparatus and methods are described for drilling deep boreholes with millimeter-wave radiation in earthen materials to access deep resources such as geothermal heat. Borehole depth and temperature at the bottom of the borehole can be monitored with probe signals and/or radiative emission from the bottom of the borehole.
E21B 47/135 - Means for transmitting measuring-signals or control signals from the well to the surface, or from the surface to the well, e.g. for logging while drilling by electromagnetic energy, e.g. of radio frequency range using light waves, e.g. infrared or ultraviolet waves
59.
BIOMOLECULE-POLYMER-PHARMACEUTICAL AGENT CONJUGATES FOR DELIVERING THE PHARMACEUTICAL AGENT
The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease.
C07C 323/41 - Y being a hydrogen or an acyclic carbon atom
C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
A61K 39/00 - Medicinal preparations containing antigens or antibodies
C07C 217/62 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
C07C 233/16 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
C07C 235/74 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
C07C 323/31 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
C07C 323/32 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
C07D 207/46 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for segmentation of vessels of interest from image data. The image analysis provides for guidance for insertion of a cannulation system into a subject which may be accomplished by a non-expert based upon the guidance provided. The guidance may include an indicator or a mechanical guide to guide a user for inserting the vascular cannulation system into a subject to penetrate the vessel of interest.
A method for configuring an electromechanical system to perform a first task includes accepting a specification of the first task, accepting first user input from an operator related to the first task, the first user input including a representation of user- referenced points, and forming control data for causing the system to perform the task based on the specification of the first task and the first user input.
Optical and electronic processors for calculating second-order and higher-order polynomials are described. A photonic processor can include an optical matrix multiplying unit OMMU that can perform vector-matrix multiplication. A portion of the inputs to the OMMU can be fed forward to combine with outputs from the OMMU when calculating polynomials. The described apparatus can also be used for probabilistic computing and polynomial combinatorial optimization.
Apparatus and methods for monitoring emissions from a borehole to determine the composition of earthen material removed from the borehole are described. Monitoring can be done in real time as the borehole is being deepened with a millimeter-wave drilling beam. The present technology can monitor in real-time the elemental composition of the earthen materials (e.g., rock, minerals, crystals, metals, etc.) in a borehole created by a directed-energy beam that melts and vaporizes the earthen material materials in its path. Using a continuous emissions monitor (CEM) in combination with directed-energy excavation of a borehole enables rapid surveying of the subsurface for precious and commercial metals.
G01N 21/67 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence using electric arcs or discharges
64.
CONTROLLABLE TRANSFORMATION NETWORKS FOR RADIO FREQUENCY POWER CONVERSION
In one aspect, a system for transforming a radio frequency (RF) signal between a source and a load can include: a first port and a second port connected to different ones of the source and the load; a first filter connected to the first port; a second filter connected to the second port, at least one of the first and second filters operable to provide variable reactance using dynamic frequency tuning (DFT); a two-port switching network connected between the first filter and the second filter, the switching network comprising a plurality of switches; and a controller coupled to the switching network and to the source, the controller configured to operate the plurality of switches according to a switching pattern and to dynamically adjust a frequency of the RF signal to provide controllable impedance matching between the first port and the second port.
Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel Fanzor polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.
Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).
C07D 211/14 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
C07C 219/16 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
C07D 211/42 - Oxygen atoms attached in position 3 or 5
C07D 213/42 - Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
The present disclosure provides, in some aspects, a humanized immunodeficient mouse model of human fibrosis. A humanized immunodeficient mouse model provided herein may be used, for example, for modeling human fibrosis, predicting human fibrosis, and testing putative fibrosis treatments.
Immunization methods are provided. The methods typically include administering the subject an effective amount of an antigen and adjuvant to induce an immune response against an antigen, the method including two or more of (i) slow prime delivery of antigen and/or adjuvant, a (ii) temporally delayed 2nd immunization, and (iii) a robust adjuvant. Element (i) can be or include temporally extended exposure of antigen, adjuvant, or preferably the combination thereof, such as one or more of repeated administrations, infusion optionally by osmotic pump and escalating dosing. Element (ii) can include administering one or more boost doses of antigen and/or adjuvant, for example between 11 and 35 weeks after the start of the prime administration. A preferred robust adjuvant (iii) is one including non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin.
This disclosure provides complexes for prime editing comprising an RNA-guided nuclease, a fusion protein comprising a reverse transcriptase domain linked to a nucleic acid binding protein, and a guide RNA (gRNA) comprising at least one protein-recruiting stem-loop nucleic acid sequence, wherein the protein-recruiting stem-loop nucleic acid sequence binds to the nucleic acid binding protein. Also provided are systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE) with integration enzymes paired with the prime editing complex.
PREDICTION, BIOSYNTHESIS, AND INTEGRATION AS BIOSENSORS OF MOLECULES WITH UNIQUE LIGHT ABSORBANCE SIGNATURES AND THEIR SUBSEQUENT IN-FIELD REMOTE DETECTION USING MULTI OR HYPER-SPECTRAL CAMERAS
Disclosed herein are biosensors that are hyperspectral reporters. The biosensors are useful for detecting information about the environment and environmental conditions in a number of fields including agriculture. Also provided are methods of making and using the biosensors.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
72.
SYNTHESIS OF ESTER, CARBONATE, AND CARBAMATE-DERIVED NOVEL BIODEGRADABLE IONIZABLE LIPIDS FROM METHYL RICINOLEATE OR METHYL 12-HYDROXYSTEARATE AND ITS APPLICATIONS
C07C 229/12 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
C07C 229/16 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C07D 233/24 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
C07D 211/34 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07D 225/02 - Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
73.
COLD-TEMPERATURE ISOTHERMAL AMPLIFICATION OF POLYNUCLEOTIDES
In some aspects, the present disclosure provides methods and compositions for isothermal low temperature amplification of target polynucleotides, and detection thereof.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
74.
SYSTEMS, DEVICES, AND METHODS FOR ENHANCING THE NEUROPROTECTIVE EFFECTS OF NON-INVASIVE GAMMA STIMULATION WITH PHARMACOLOGICAL AGENTS
A method for increasing phase locking of neurons to gamma oscillations in at least one brain region of a subject for treating Alzheimer's disease in the subject in need thereof includes administering an inhibitor including a colony-stimulating factor- 1 receptor (CSF1R) inhibitor or a colony- stimulating factor-1 (CSF1) inhibitor to the subject. The method also includes administering a stimulus to the subject having a frequency from about 20 Hz to about 60 Hz.
A61M 21/00 - Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
A system and method for patterned growth of halide perovskite nanocrystals is disclosed. This method allows control over the size, number and position of the nanocrystals, while ensuring compatibility with device integration processes. The method uses a topographical template comprising a plurality of wells with asymmetric surface wetting to confine the nanocrystal growth to within the wells. Further, the shape and surface wetting properties of the wells are used to induce local directional forces to guide nanocrystal positioning during the growth process. With this technique, scalable arrays of nanocrystals with tunable dimensions and precise positional accuracy are possible. As an example, this method allows arrays of active nanoscale perovskite light emitting diodes (LEDs).
H01L 33/20 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a particular shape, e.g. curved or truncated substrate
H01L 33/26 - Materials of the light emitting region
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
78.
POLY(β-AMINO ESTER) MICROPARTICLES FOR MICRONUTRIENT FORTIFICATION
Provided herein are compounds, such as compounds of Formulae (I) and (III), and compositions, methods, uses, and kits thereof. The compounds provided herein are poly(β- amino esters) useful for delivery of agents, such as vitamins and minerals, for the treatment and/or prevention of various diseases and conditions (e.g., micronutrient deficiency).
C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule; Polyhydrazides; Polyamide acids or similar polyimide precursors
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Disclosed are conjugates and methods of identifying ligands for substrates using said conjugates. Also disclosed herein are methods of making the conjugates.
C07K 1/04 - General processes for the preparation of peptides on carriers
C40B 50/16 - Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
Architected materials are vascularized with air-filled channels, imbuing structures with fluidic sensing, actuation, and programmed mechanical behaviors.
Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are rovided.
The present disclosure provides microcapsules comprising a silk fibroin polypeptide and one or more active payload, materials, and formulations comprising the microcapsules of the disclosure. Also provided are methods of preparing and methods of using the microcapsules of the disclosure.
Meta-optic systems are described that include multi-function metasurfaces formed from a plurality of meta-atoms. A multi -function metasurface can exhibit two or more different optical functions for two or more different states of light incident on the metasurface. Different states of light include different polarizations, different wavelengths, and different angles of incidence. Different optical functions include distance sensing, converging, diverging, image formation, and patterned light formation. The multi-function metasurface can selectively impart different phase profiles to an incident beam depending on the incident beam's state of light.
G02B 1/00 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
G02B 1/118 - Anti-reflection coatings having sub-optical wavelength surface structures designed to provide an enhanced transmittance, e.g. moth-eye structures
Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IsrB polypeptides, novel IsrB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.
The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.
A61K 31/401 - Proline; Derivatives thereof, e.g. captopril
C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
86.
LIVE-CELL LABEL-FREE PREDICTION OF SINGLE-CELL OMICS PROFILES BY MICROSCOPY
Computer-implemented methods, computer program products, and systems determine an omics profiles of a cell using microscopy imaging data. In one aspect, a computer-implemented method determines an omics profiles of a cell using microscopy imaging data by a) receiving microscopy imaging data of a cell or a population of cells; b) determining a targeted expression profile of a set of target genes from the microscopy imaging data using a first machine learning model, the target genes identifying a cell type or cell state of interest; and c) determining a singlecell omics profile for the population of cells using a second machine learning algorithm model. The targeted expression profile and a reference single-cell RNA-seq data set are used as inputs for the second machine learning model.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
87.
RAPID, POINT OF CARE DETECTION OF NEUTRALIZING ANTIBODIES AGAINST SARS-COV-2
Described are rapid, point of care tests to detect circulating neutralizing antibodies against SARS-CoV-2 in a biological sample obtained from patients.
Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration / exfiltration) in a processing pipeline.
Multifunctional microelectronics fiber probes can be chronically implanted in tissue of awake- behaving animals for understanding brain-viscera communication. These fiber probes can be made using thermal drawing to make hundreds of meters of flexible fiber that incorporates features such as light sources, electrodes, thermal sensors, and microfluidic channels in a multilayered configuration. The fiber mechanics can be tuned for two distinct device layouts: (1) higher- modulus, flexible brain fibers for implantation into deep-brain; and (2) soft, compliant gut fibers for implantation into the small intestine. Brain fibers can modulate the deep-brain mesolimbic reward pathway. Gut fibers can perform peripheral optogenetic stimulation of vagal afferents from the intestine to stimulate brain reward neurons. Brain and gut fibers can be connected to a control module, for example, with a coiled, stretchable interconnect that is more flexible and stretches more than even soft gut fibers, in dual-organ (gut-brain) implantation.
Articles, compositions, and methods describing particles comprising micelles are generally described. In some embodiments, the micelles are configured to absorb pollutants from water and subsequently release the pollutants to a non-aqueous environment.
B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
B01D 53/72 - Organic compounds not provided for in groups , e.g. hydrocarbons
Systems and methods disclose a practical implementation of optimal modulation (OM) for the Complex Additive White Gaussian Noise (CAWGN) channel. At the sender, we map from uniform distributions of data to non-uniform distributions of points in constellations by using a technique inspired by Huffman codes. We replace Gray codes with a bit mapping suited to our constellations, where different points may map to string of bits of different lengths. At the receiver, we perform distribution-aware detection. The differing lengths of bits for modulation points can used as a simple checking mechanism that, when combined with guessing random additive noise decoding (GRAND), yields bit-error-rate (BER) advantages.
Described are concepts, systems, structures and techniques for metal filling an open channel (12) in a baseplate (19). In embodiments, metal filling of an open baseplate channel is achieved using vacuum pressure impregnation (VPI). In embodiments, a compression plate (14a) is disposed over an open baseplate channel (12) to be filled with a molten metal. In embodiments, gaskets (97) are disposed between the compression plate (14a) and a surface of the baseplate (10) proximate the baseplate channel (12). In embodiments, a channel cap (26) is disposed over the open channel. In embodiments, the channel cap (26) has a solder flow channel (29, 32) provided in a surface thereof. In the embodiments, the solder flow channel (29, 32) has a meandering shape. In embodiments, a solder flow channel (29, 32') is provided in the compression plate (14a) and/or the baseplate (10). The concepts, systems, structures and techniques described herein are suitable for use in the fabrication of a no-insulation, no-twist (NINT) high temperature superconducting (HTS) magnet.
H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils
Hie disclosure provides zymography probes of the general formula X1-X2-X3, wherein one of XI and X3 is a cationic peptide linked to a fiuorophore, and the other is an anionic peptide, and X2 is protease-cleavable peptide, and their use for activity based cell sorting.
A method for making a lithium salt film includes heating a substrate, spraying a mixture with a spray nozzle onto the substrate to form a precursor film, and annealing the precursor film to form the lithium salt film. The lithium salt film has a thickness of about 400 nm to about 100 pm. The spray mixture includes a first precursor comprising a lithium ion, a second precursor comprising an anion, and a solvent.
A high capacity current lead (10) comprises components that are electrically coupled using indium joints. The current lead includes a heat exchanger having a portion at room temperature (100) and a portion (200) within a vacuum cryostat. The room-temperature portion is temperature controlled against both overheating and overcooling. The cryogenic portion (200) of the heat exchanger is electrically coupled to a coolant boiling chamber (300) using indium joints. The boiling chamber (300) has a lid and a base that may be electrically coupled using indium joints, or they may be brazed. The boiling chamber (300) is surrounded by a vacuum lid that may be electrically coupled to the base using indium joints, or brazed. The base is electrically coupled to a superconductor module (400) having high-temperature superconductor (HTS) tapes for conveying current to a device, such as a superconducting electromagnet.
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
Inventor
Khaykovich, Boris
Zheng, Guiqiu
Splrouster, David
Abstract
A system for determining atomic structure and dynamics of salt under certain temperatures as a function of temperature above and below salt melting, contains a quartz tube containing a first end and a second end, and a graphite rod that is located within the quartz tube. The graphite rod contains a hollow center that extends from a top portion of the rod to a location prior to a bottom of the rod, wherein the bottom portion of the rod is enclosed. A sample of salt is located within the hollow center of the graphite rod. A filling material having the characteristics of not reacting to the graphite rod and not changing state with heating of the salt to a melting point of the salt, and wherein the filling material is positioned beneath the graphite rod between the second end of the quartz tube and the bottom of the graphite rod.
G01N 21/09 - Cuvette constructions adapted to resist hostile environments or corrosive or abrasive materials
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
97.
DISPERSIVE OPTICS FOR SCALABLE RAMAN DRIVING OF HYPERFINE QUBITS
A device for modulating an amplitude of a light beam, comprising a coherent light source configured to generate a phase -modulated beam having a plurality of frequency components; and a dispersive optical element. The dispersive optical element has a group delay dispersion and is configured to receive the phase-modulated beam, to introduce an optical phase shift to each of the plurality of the frequency components, so that the values of the optical phase shift vary non-linearly with frequency according to the group delay dispersion, and to recombine the plurality of frequency components, thereby generating an amplitude -modulated beam.
G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
H04B 10/2519 - Arrangements specific to fibre transmission for the reduction or elimination of distortion or dispersion due to chromatic dispersion using Bragg gratings
G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
G02F 1/11 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on acousto-optical elements, e.g. using variable diffraction by sound or like mechanical waves
G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
H01S 3/108 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using non-linear optical devices, e.g. exhibiting Brillouin or Raman scattering
98.
CONTACTLESS STRESS MONITORING USING WIRELESS SIGNALS
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (USA)
Inventor
Adib, Fadel
Ha, Unsoo
Madani, Seyedsohrab
Abstract
According to one aspect of the disclosure, a method for measuring stress of a subject includes: transmitting, by a sensor, a wireless signal within an environment comprising the subject; measuring reflections of the wireless signal to generate a physiological signal responsive to changes in distance between the subject and the sensor over time; processing the physiological signal to extract feature data of the subject; and providing the feature data as input to a stress classification network to determine a stress level of the subject.
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
99.
METHODS, APPARATUS, COMPOSITIONS OF MATTER, AND ARTICLES OF MANUFACTURE RELATED TO ADDITIVE MANUFACTURING OF POLYMERS
Systems, methods, and compositions for using Interfacial Photopolymerization (IPP) for high-resolution digital processing of polymers are disclosed. In IPP, a polymer film can be formed at an interface between two liquids, each containing a species involved in a polymerization reaction. The two liquids can include a photoinitiator and a monomer that are immiscible and/or reactive such that the film can form at the interface. The polymerization reaction can be controlled by a LED light source, which is focused at a reaction zone located at or near the liquid-liquid interface. The resulting polymer results in a high-resolution, high-throughput AM of thermoplastic polymers that enables on-demand production of objects that exhibit exceptional dimensional quality, mechanical properties, and recyclability characteristics.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C08G 63/06 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxy carboxylic acids
patents
