Abstract

Disclosed is a hybrid polymeric system containing (a) a polymer matrix containing polymeric particles dispersed within the polymer matrix, and (b) therapeutic, diagnostic, nutraceutical, and/or prophylactic agents encapsulated in the polymeric particles, for these agents. The polymer matrix and the polymeric particles have different degradation rates, such that the degradation rate of the polymer matrix is less than that of at least one of the polymeric particles, such that when the hybrid polymeric system is administered to a subject in need thereof, the hybrid polymeric system remains at the site of administration, while the encapsulated polymeric particles degrade to release these agents. The hybrid polymeric system is particularly suited for progressive and/or chronic diseases or disorders that require prolonged periods of release of therapeutic, prophylactic, or diagnostic agents, and diseases or disorders that require repeated administration of these agents.

IPC Classes  ?

• A61F 13/00 - Bandages or dressings; Absorbent pads
• C08L 35/02 - Homopolymers or copolymers of esters

Abstract

According to some embodiments, a system includes: a first neuron configured to generate a first firing waveform; a second neuron configured to generate a second firing waveform; an electrochemical ionic (EIS) synapse; and a circuit electrically connecting the first and second neurons via the EIS synapse and configured to modulate conductivity of the electrical connection provided by the EIS synapse based on relative timing of the first and second firing waveforms. The waveform shapes can be selected to implement a spike-timing-dependent plasticity (STDP) learning rule in the EIS synapse.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

Engineered Type V Cas polypeptides with reduced immunogenicity, CRISPR-Cas systems thereof, compositions thereof, delivery systems thereof, and methods of use thereof for modifying target polynucleotides, such as, for example, in cells.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases

Abstract

Engineered Type II Cas polypeptides with reduced immunogenicity, CRISPR-Cas systems thereof, compositions thereof, delivery systems thereof, and methods of use thereof for modifying target polynucleotides, such as, for example, in cells.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/09 - Recombinant DNA-technology
• A61K 38/16 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

Described are central solenoid (CS) retaining structures and related assembly techniques. Also described are assembly techniques for a tokamak fusion reactor.

IPC Classes  ?

• G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
• G21B 1/11 - Thermonuclear fusion reactors - Details

Abstract

A flexible robotic limb and associated methods of operation are disclosed. The flexible robotic limb may include a flexible backbone and a channel extending along a length of the flexible backbone. A flexible inflatable structure may be configured to invert into and evert out from a distal end portion of the flexible backbone. In some embodiments, extension of the flexible backbone and inversion and eversion of the flexible inflatable structure may be controlled independently to permit a relative length of an everted portion of the flexible inflatable structure extending beyond a distal end portion of the flexible backbone to be controlled.

IPC Classes  ?

• B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
• D06G 3/02 - Turning inside-out flexible tubular or other hollow articles by mechanical means
• F01B 19/04 - Positive-displacement machines or engines of flexible-wall type with tubular flexible members
• B25J 18/06 - Arms flexible

Abstract

A robotic hand includes one or more fingers. Each finger includes an articulated rigid skeleton including a number of rigid sections connected by one or more joints, wherein at least some of the rigid sections are connected to one or more actuators by linking elements for imparting motion to the articulated rigid skeleton, and an elastic material formed around the articulated rigid skeleton and at least some of the linking elements such that the articulated rigid skeleton, the at least some of the linking elements, and the elastic material form a unitary structure.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• B25J 15/00 - Gripping heads

Abstract

Segmented flexible robotic limbs with low bending stiffnesses and high compressive stiffnesses are disclosed. The disclosed flexible robotic limbs may include inverting/everting flexible inflatable structures that include a plurality of serially arranged interconnected chambers that include connections between adjacent interconnected chambers. The connections fluidly coupling adjacent interconnected chambers may have smaller transverse cross sectional areas perpendicular to a longitudinal axis of the robotic limb than the adjacent interconnected chambers in the inflated configuration.

IPC Classes  ?

• B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
• D06G 3/04 - Turning inside-out flexible tubular or other hollow articles pneumatically
• B25J 18/02 - Arms extensible
• B25J 18/06 - Arms flexible
• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• F01B 19/04 - Positive-displacement machines or engines of flexible-wall type with tubular flexible members
• F15B 15/10 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type

Abstract

Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.

IPC Classes  ?

• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

Abstract

A unified quantum network architecture is introduced that seamlessly applies to all memory types while sharply reducing experimental overhead. The scheme depends on the following elements: A unified quantum network framework based on photon heralding. As a unified quantum network framework, a scheme for optically heralded entanglement that applies to superconductor-to-optical interfaces equally as to other memory-photon interfaces (such as spin-photon interfaces, and others). To address the challenges noted above, a scheme termed "Universal Quantum Bus" (UQB) is introduced. UQB is described for connecting diamond color centers across a telecom fiber network, however the scheme works equally for all other memory types.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms

Abstract

OSS|). When combined with a modified Platt scaling loss, the disclosed algorithm can provide at least a 100-fold speedup over a Kernel-Inducing Points (KIP) algorithm and can run on a single graphics processing unit. The disclosed Random Feature Approximation Distillation (RFAD) algorithm can perform competitively with other dataset condensation algorithms in accuracy over a range of large-scale datasets, both in kernel regression and finite-width network training. The disclosed techniques can be effective on tasks such as model interpretability and data privacy preservation.

IPC Classes  ?

• G06N 3/047 - Probabilistic or stochastic networks
• G06N 3/048 - Activation functions
• G06N 3/09 - Supervised learning
• G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
• G06V 10/776 - Validation; Performance evaluation
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

Methods of implanting biomaterials and devices in a patient, such as methods that include arranging an adhesive composition between and in contact with a biomaterial or a device, and a surface of a tissue of the patient. An adhesive composition may be configured to form at a surface of a tissue a conformal interface that reduces or minimizes infiltration of inflammatory cells at the conformal interface.

IPC Classes  ?

• A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
• A61L 31/04 - Macromolecular materials
• A61L 24/00 - Surgical adhesives or cements; Adhesives for colostomy devices

Abstract

A system and method for measuring qubit states. In some embodiments, the system includes a first qubit and a readout circuit, the readout circuit being configured to perform a direct readout of the state of the first qubit.

Abstract

Ultrafast methods to prepare high-density DNA functionalized nanoparticles using solution-based fabrication and application to aligned 2D QR lattices with nanometer scale spatial accuracy are described.

Abstract

The invention relates to compositions and methods tor targeting polynucleotides with eukaryotic RNA-guided nucleases. In particular, a non-naturally occurring, engineered composition comprising: (a) a Fanzor polypeptide comprising an RuvC domain; and (b) a fRNA molecule comprising a scaffold and a reprogrammable target spacer sequence, wherein the fRNA molecule is capable of forming a complex with the Fanzor polypeptide and directing the Fanzor polypeptide to a target polynucleotide sequence.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

A method of forming deterministic perovskite nanocrystals on a substrate is disclosed. The method includes preparing a perovskite forming precursor solution comprising a mixture of a solvent, perovskite precursors, and optionally surface passivation ligands and/or a host matrix. This perovskite forming precursor solution is deposited on a substrate by spin-coating, blade-coating or other deposition techniques to produce a layer comprising perovskite precursors, also referred to as a deposited perovskite forming precursor film. Then, a region of the film is locally heated to transform the perovskite precursors into perovskite nanocrystals and deterministically form an arbitrary pattern comprising clusters of the perovskite nanocrystals with control down to a single nanocrystal. The localized heating may be accomplished using thermal scanning probe lithography or lasers or a combination.

IPC Classes  ?

• C30B 29/60 - Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape characterised by shape
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions

Abstract

An electrostatic thin-shell structure concept capable of actively controlling the shape of large area systems with minimal mass overhead and complexity is described. The structure comprises an assembly of collapsible thin-shell cells for which the cross-section follows the classical collapsible tubular mast architecture. Two conductive electrodes are added to the top and bottom flanges of the cell. An electrostatic force develops between top and bottom electrodes upon voltage application, which flattens the cross-section and causes the cell to expand longitudinally. When multiple layers of these cells are bonded to each other, the controlled differential expansion of each layer can be harnessed to cause global bending.

IPC Classes  ?

• H02N 1/00 - Electrostatic generators or motors using a solid moving electrostatic charge carrier
• B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes

Abstract

Flow devices for irrigation, also referred to as emitters or drip emitters, having improved operating parameters are disclosed. The emitters can be low-pressure and compact, designed for use within an irrigation tube or line, also referred to as inline, and can enable affordable, clean-energy technology for drip irrigation. The emitter can include a diaphragm pocket, a channel, and/or a labyrinth passage recessed within the body to regulate flow. The emitter can be designed for low activation pressure, consistent pressure compensation operation up to 4 bars of inlet pressure, and compact as compared to conventional emitters. In some embodiments, the channels of the labyrinth passage can be sufficiently wide to support superior clog resistance while having a flow-cross section that can allow a particle sized up to about 0.425 mm to flow therethrough without clogging.

Abstract

Provided herein are compositions, methods, and kits relating to the formation and deconstruction of thermosets capable of storing biomolecules.

IPC Classes  ?

• B01J 13/02 - Making microcapsules or microballoons
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

Provided herein are bifunctional compounds that bind cyclin-dependent kinase 9 (CDK9) and/or promote targeted ubiquitination for the degradation of CDK9, a protein whose dysregulation is implicated in certain cancers. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating cancer, methods of promoting the degradation of CDK9 and/or IKZF1, and methods of promoting the selective degradation of CDK9 (e.g., over IKZF1) by a compound or composition described herein.

IPC Classes  ?

• A61P 35/00 - Antineoplastic agents
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• C07D 487/04 - Ortho-condensed systems

Abstract

Described in certain exemplary embodiments herein are engineered Anti-CRISPR (Acr) polypeptides and delivery systems engineered for delivery to the cytosol and/or nucleus of cells. In certain embodiments, an engineered Acr polypeptide comprises an Acr polypeptide operatively coupled to a cargo delivery molecule, wherein the cargo delivery molecule is capable of binding or otherwise interacting with a pore-forming polypeptide. Also described in certain exemplary embodiments are methods of Acr delivery to cells via the engineered Acr polypeptides and delivery systems of the present disclosure.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

A mechanochemical process to synthesize single-crystalline cathode powders for the formation of cathodes in a lithium-ion battery includes mixing a transient metal oxide precursor with a lithium salt mixture. Thereafter, a mechanical agitation process may be applied to selectively melt the lithium salt mixture to form a molten salt liquid that wets, corrodes, and separates the grain boundaries of secondary particles in the transient metal oxide precursor. As a result, the secondary particles are deagglomerated resulting in a colloidal dispersion of primary particles. The mixture is then calcined to facilitate growth of single-crystalline particles from the primary particles, thus forming a single-crystalline cathode powder. The single-crystalline particles exhibit large particle size and little to no phase separation, thus improving electrochemical performance. This highly scalable process can be used to synthesize single-crystalline cathode powders from chemical-grade precursors or black mass.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/505 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61K 31/33 - Heterocyclic compounds

Abstract

Aspects of the disclosure relate to expression cassettes encoding miniShank3 proteins, AAV vectors comprising the expression cassettes, and gene therapy methods. In particular, the expression cassettes is formulated to further comprise AAV9 capsids, and the gene therapy is useful for treating neuroveleopmental disorders such as autism spectrum disorder (ASD) and Phelan-McDermid syndrome.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 25/00 - Drugs for disorders of the nervous system
• C12N 15/86 - Viral vectors

Abstract

What is described is a method of growing a two-dimensional (2D) material on a substrate, the method comprising: (a) forming a mask layer on the substrate; (b) forming a trench in the mask layer, the trench having sidewalls formed in the mask layer surrounding an exposed portion of the substrate; and (c) depositing a nucleus of the 2D material on the exposed portion of the substrate and growing the nucleus into a single-domain monolayer of the 2D material, wherein the depositing and the growing of the nucleus is performed at a temperature less than 705 °C.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C23C 14/04 - Coating on selected surface areas, e.g. using masks
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C23C 14/22 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
• C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides

Abstract

Techniques for use in connection with determining a collection, time, and usage optimized route for a vehicle may include obtaining collection, usage, and time optimized reachable sets, obtaining a Pareto front of Pareto solutions for optimum time and optimum collectible, reachable at a target final location and target collectible level, and using the Pareto solutions to provide an optimized route for the vehicle. The vehicle may be guided using the optimized route and may collect an enhanced quantity of a collectible along the optimized route.

IPC Classes  ?

• G01C 21/34 - Route searching; Route guidance
• G06Q 10/047 - Optimisation of routes or paths, e.g. travelling salesman problem

Abstract

Disclosed herein are silicates and/or salts and methods of production and uses thereof. For example, methods of producing an amorphous silicate and/or a salt from materials comprising silicates are disclosed. As another example, use of silicates and/or salts in the formation of cementitious materials is also disclosed.

IPC Classes  ?

• C04B 14/06 - Quartz; Sand
• C04B 18/06 - Combustion residues, e.g. purification products of smoke, fumes or exhaust gases
• C04B 28/02 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
• C01B 33/20 - Silicates

Abstract

The techniques described herein relate to systems, apparatus, articles of manufacture, and methods for improving speech understanding of users. An example method includes obtaining at least one speech comprehension metric indicating a degree to which the user comprehends audible speech. The method further includes obtaining speech information to be output to the user, the speech information representing audible speech communicated to the user. The method additionally includes determining modulated speech information using a cognitive speech model with the at least one speech comprehension metric and the speech information, and outputting the modulated speech information to the user.

IPC Classes  ?

• G10L 15/00 - Speech recognition
• G10L 15/01 - Assessment or evaluation of speech recognition systems

Abstract

Systems and methods are provided herein for inducing quench in a non-insulated superconducting magnet. Some techniques described herein provide for operating the non-insulated superconducting magnet by applying a first current to the non-insulated superconducting magnet, and inducing quench in the non-insulated superconducting magnet at least in part by applying a second current to the non-insulated superconducting magnet, wherein the second current is opposite in direction to the first current.

IPC Classes  ?

• H01F 6/02 - Quenching; Protection arrangements during quenching
• H02H 7/00 - Emergency protective circuit arrangements specially adapted for specific types of electric machines or apparatus or for sectionalised protection of cable or line systems, and effecting automatic switching in the event of an undesired change from norm
• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

Abstract

The invention provides for systems and methods for inserting large polynucleotides into precise locations in a target polynucleotide. In one aspect, the systems comprise an engineered Type I-D/Tn7 CRISPR-associated transposase system (CAST) comprising a Tn7-like transposase linked to or otherwise capable of associating with a Type I-D CRISPR-Cas complex (Tn7-CAST I-D). In another aspect, the systems comprise a Tn7-like transposase comprising a modular target site selection protein, called TnsF, that may be engineered to reprogram the Tn7-like transposase to facilitate insertion at different sites in a target polynucleotide. In another aspect, the systems comprise a transposon system comprising a tyrosine recombinase which provides for scar-less insertion of large donor sequences into target polynucleotides. Also provided are methods for modifying target polynucleotides using the systems; polynucleotides encoding the systems; delivery systems for delivering the components of the systems; and cells and biological products modified by or modified to include the systems.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

o4 44.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G02F 1/017 - Structures with periodic or quasi periodic potential variation, e.g. superlattices, quantum wells
• H01L 29/12 - Semiconductor bodies characterised by the materials of which they are formed
• H10N 60/30 - Devices switchable between superconducting and normal states
• H10N 60/81 - Containers; Mountings
• H10N 60/84 - Switching means for devices switchable between superconducting and normal states
• H10N 60/85 - Superconducting active materials
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms
• G06N 10/80 - Quantum programming, e.g. interfaces, languages or software-development kits for creating or handling programs capable of running on quantum computers; Platforms for simulating or accessing quantum computers, e.g. cloud-based quantum computing

Abstract

A catheter system for obtaining a pressure profile of a gastrointestinal (GI) tract includes a catheter configured to be inserted endoluminally into the GI tract. The catheter includes an outer sheath defining a first lumen and sensing unit enclosed within the first lumen. The sensing unit includes a plurality of pressure sensors spaced apart along the flexible printed circuit board that is supported on a support structure. The support structure is made of a shape memory material that is configured to transition from a first configuration to a second configuration following insertion of the catheter into the GI tract. The second configuration includes a first region shaped to conform to a first portion of the GI tract and a second region shaped to conform to a second portion of the GI tract that is distinctly shaped from the first portion of the GI tract.

IPC Classes  ?

• A61B 5/392 - Detecting gastrointestinal contractions
• A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes

Abstract

According to certain embodiments, a composition comprising a polymer of intrinsic microporosity (PIM) is described. In some embodiments, the PIM comprises a polyamide comprising a first micropore-generating moiety (e.g., a spirobifluorene moiety) crosslinked with at least one second micropore-generating moiety (e.g., a Tröger's base moiety) via an amide bond. The first moiety and the second moiety may be substantially rigid such that neither moiety contains any carbon-carbon or carbon-heteroatom single bonds. The resulting rigid polyamides formed from the micropore-generating units have advantageous properties, including, for example, sufficiently small pore sizes, large fractional free volumes, and high surface areas. Furthermore, the pore sizes, fractional free volumes, and surface areas of the polyamides may advantageously be tuned depending on the choice of the first moiety and the second moiety.

IPC Classes  ?

• B01D 61/027 -
• B01D 67/0006 -
• B01D 67/0002 -
• C02F 1/442 -

Abstract

A barrier coating that is resistant to delamination includes a glass-ceramic phase and a metallic phase. The glass-ceramic phase protects an underlying substrate against environmental hazards. The metallic phase provides ductile reinforcement of the barrier coating, in part, by forming a percolating network throughout the barrier coating, thus improving delamination resistance. In one example application, the barrier coating is applied to a component of an oxygen-rich turbopump (e.g., a turbine blade) for use in a reusable rocket engine. In this example, the barrier coating protects, for example, a component formed of a Ni superalloy against particle impact ignition by an oxygen-rich gas stream.

IPC Classes  ?

• F02F 7/00 - Casings, e.g. crankcases
• F01D 5/28 - Selecting particular materials; Measures against erosion or corrosion
• F02K 9/60 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof using liquid or gaseous propellants - Details not otherwise provided for
• C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and

Abstract

Disclosed herein is a near infrared (nIR) fluorescent nanosensor for detecting iron species, comprising a complexation of individual single-walled carbon nanotubes (SWNT), wherein the SWNT are nIR fluorescent, and a water-soluble polymer. The nIR fluorescent nanosensors offer a specific and sensitive sensing platform for quantification and speciation of dissolved or bioavailable Fe(II) and Fe(III) in both their free ionic and chelated forms, and have been demonstrated for use in detection of iron via root uptake in planta, as well as in the detection of "free" or non-transferrin bound iron (NTBI) in human serum.

IPC Classes  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• C08K 3/04 - Carbon
• C08G 69/32 - Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids from aromatic diamines and aromatic dicarboxylic acids with both amino and carboxylic groups aromatically bound
• C08L 77/10 - Polyamides derived from aromatically bound amino and carboxyl groups of amino carboxylic acids or of polyamines and polycarboxylic acids
• C08F 238/00 - Copolymers of compounds having one or more carbon-to-carbon triple bonds
• C08L 49/00 - Compositions of homopolymers or copolymers of compounds having one or more carbon-to-carbon triple bonds; Compositions of derivatives of such polymers
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Embodiments related to methods and systems for using control arms operated in a controller space that is linearly mapped to a world space for controlling operation of a machine with an end effector are disclosed.

IPC Classes  ?

• G05G 9/047 - Manually-actuated control mechanisms provided with one single controlling member co-operating with two or more controlled members, e.g. selectively, simultaneously the controlling member being movable in different independent ways, movement in each individual way actuating one controlled member only in which movement in two or more ways can occur simultaneously the controlling member being movable by hand about orthogonal axes, e.g. joysticks
• E02F 9/20 - Drives; Control devices
• G05G 1/01 - Arrangements of two or more controlling members with respect to one another
• E02F 3/28 - Dredgers; Soil-shifting machines mechanically-driven with digging tools mounted on a dipper- or bucket-arm, e.g. dippers, buckets
• G05D 1/02 - Control of position or course in two dimensions
• A61B 34/37 - Master-slave robots

Abstract

Aspects of the present disclosure relate to modified yeast cells capable of producing increased quantities of squalene as compared to unmodified yeast cells and methods of using the same.

IPC Classes  ?

• C12P 5/00 - Preparation of hydrocarbons
• C12N 1/16 - Yeasts; Culture media therefor
• C12R 1/72 - Candida
• C12R 1/85 - Saccharomyces
• C07K 14/255 - Salmonella (G)

Abstract

Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycemia, anaphylaxis, and cardiac arrest. A miniaturized (e.g., < 3 cm3), lightweight (e.g., < 2 g), minimally invasive fully wireless, emergency rescue device for the storage and active burst-release of indefinitely stable particulate forms of peptide and hormone drugs into subcutaneous sites for direct reconstitution in interstitial biofluids is disclosed. The device demonstrates a fast (e.g., < 5 minutes) therapeutic effect. The device may deliver a drug across fibrotic tissue, which commonly accumulates following in vivo implantation, thereby accelerating systemic delivery. Fully wireless delivery of dry particulate glucagon in vivo is demonstrated, providing emergency hypoglycemic rescue in diabetic mice. Additionally, triggered delivery of epinephrine is demonstrated in vivo. Additionally, disclosed herein is a platform for the long-term in vivo closed loop delivery of emergency rescue drugs.

IPC Classes  ?

• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
• A61J 1/03 - Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• B65D 83/04 - Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
• A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A hanging drop device for vitrification of a specimen includes a housing, a plurality of microfluidic channels disposed in the housing and a plurality of inlets disposed in the housing. Each inlet is connected to and in fluid communication with at last one of the plurality of microfluidic channels. The hanging drop device further includes an outlet disposed in the housing and connected to and in fluid communication with at least one of the plurality of microfluidic channels, and an opening disposed in the housing and connected to and in fluid communication with each of the plurality of microfluidic channels. The opening is configured to form a hanging drop chamber from a liquid loaded into the opening and the hanging drop chamber is configured to receive the specimen.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

Abstract

Modular Rydberg architectures for fault tolerant quantum computing are provided. A first array and a second array of neutral atoms are provided. Each neutral atom has a first state and an excited Rydberg state. Each neutral atom is arranged to impose a Rydberg blockade on at least its nearest neighbors in its array when in the excited Rydberg state, thereby implementing a plurality of physical qubits. Each array comprises data qubits, and syndrome qubits. The syndrome qubits are configured to implement a quantum error correcting code with respect to the data qubits. Each array includes a subarray of communication qubits having a lower dimensionality than the array. Each communication qubit of the first subarray forms a Bell pair with one communication qubit of the second subarray. The first and second arrays of neutral atoms are configured to interact with each other only via the communication qubits.

Abstract

A data collection and analysis method aligns data across processes and products. The method includes collecting data in real time; mapping the data to a matrix between function and data points; and multiplexing the data. An integrated manufacturing process of a plurality of intermediate and final products from mycelium includes collecting data from the system at intervals; analyzing the data; iteratively optimizing the manufacturing process from the processed data; and generating environmental certifications from the processed data. An adaptive, unified mycotecture platform in conjunction with a digital recording and analysis system monitors and iteratively optimizes growth, harvest, packaging, quality control, and payment. The platform includes a manufacturing facility(ies) having a growing section, a storage section, and a manufacturing section. The facility has one or more of sensors, rapid-deploy scaffolding, a reconfigurable press, a brick extractor, a mixer, an autoclave, a laboratory, bar coding, and an interactive software application.

IPC Classes  ?

• C12N 1/14 - Fungi ; Culture media therefor
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• G05B 19/414 - Structure of the control system, e.g. common controller or multiprocessor systems, interface to servo, programmable interface controller
• G06F 7/08 - Sorting, i.e. grouping record carriers in numerical or other ordered sequence according to the classification of at least some of the information they carry
• G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

Apparatus and methods are described for excavating earthen material with millimeter- wave (MMW) radiation or a combination of MMW radiation and mechanical apparatus. The MMW radiation can reduce costs and hazards associated with excavation using mechanical means only and/or explosives. MMW-assisted excavation has significant energy advantages over optical or long- wavelength microwave excavation techniques.

IPC Classes  ?

• E21D 9/10 - Making by using boring or cutting machines
• H05B 6/70 - Feed lines
• H05B 6/80 - Apparatus for specific applications
• E21B 21/16 - Methods or apparatus for flushing boreholes, e.g. by use of exhaust air from motor using gaseous fluids
• E21B 7/15 - Drilling by use of heat, e.g. flame drilling of electrically generated heat
• E21B 43/26 - Methods for stimulating production by forming crevices or fractures

Abstract

Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).

IPC Classes  ?

• C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 19/00 - Drugs for skeletal disorders
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

A detector for gamma irradiation comprises an oxygen ion conducting polycrystalline solid, has positively charged grain boundaries and is coupled to electrodes that measure changes in the poly crystalline solid's ionic conductance. The poly crystalline solid may include lightly doped Gd-doped CeCh, a polycrystalline ion conducting ceramic. The steady state passivation of space charge barriers at grain boundaries that may act as virtual electrodes, capturing radiation-induced electrons, in turn lowering space charge barrier heights, and thereby exclusively modulating the ionic carrier flow within the ceramic electrolytes. Such behavior may allow for an electrical response under low fields, i.e., < 2 V/cm. The polycrystalline solids disclosed herein may be used in inexpensive, sensitive, low-power and miniaturizable solid- state devices, uniquely suited for operating in harsh (high temperature, high humidity, pressure, and/or corrosive) environments.

IPC Classes  ?

• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal
• H04N 5/30 - Transforming light or analogous information into electric information

Abstract

The invention relates to a system for modifying a target biomolecule that is associated to an endogenous intracellular condensate formed by an intracellular protein comprising an Intrinsically Disordered Region (IDR), or to a system for modifying a chemical or physical property of an endogenous intracellular condensate. The system of the invention comprises as its minimal components an IDR polypeptide sequence tract comprising the Intrinsically Disordered Region of the intracellular protein, and an effector polypeptide domain capable of covalently modifying said target biomolecule.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

1YY represents a single bond, an alkylene group having 1-14 carbon atoms, a substituted alkylene group having 1-14 carbon atoms, a heteroalkylene group having 1-14 carbon atoms, and a substituted heteroalkylene group having 1-14 carbon atoms. X represents a basic functional group.

IPC Classes  ?

• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 9/127 - Liposomes
• A61K 9/51 - Nanocapsules
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.

IPC Classes  ?

• A61F 2/02 - Prostheses implantable into the body
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

Methods for transferring optically active features, such as meta-atoms and diffractive elements, formed on a planar surface to a non-planar surface with high precision are described. Optical devices having meta-atoms or other diffractive features located on non-planar and/or planar surfaces can be fabricated using the described methods. Related optical systems and components are described.

IPC Classes  ?

• G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
• G02B 3/00 - Simple or compound lenses
• G02B 27/01 - Head-up displays

Abstract

Techniques are providing for mitigating overcurrents in superconducting magnets by adding a closed loop of superconductor to the magnet that acts as an electromagnetic shield. A time-varying external magnetic field may induce a current in the closed loop, thereby generating a magnetic field that opposes the external magnetic field, and reducing the amount of current induced by the external magnetic field in the primary current-carrying superconductor of the magnet. As a result, the effect of overcurrents can be reduced or removed.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H01F 6/02 - Quenching; Protection arrangements during quenching

Abstract

Devices, systems, and methods described herein relate to a muscle interface and methods of use. The muscle interface may include an implant comprising a plurality of fine wires configured to be disposed in muscle tissue and to detect an electrical impedance at the muscle tissue; and a processor configured to determine a state of the muscle tissue based on the detected electrical impedance.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/389 - Electromyography [EMG]
• A61F 2/60 - Artificial legs or feet or parts thereof
• A61F 2/72 - Bioelectric control, e.g. myoelectric
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.

IPC Classes  ?

• B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• G16B 30/10 - Sequence alignment; Homology search
• G16B 30/20 - Sequence assembly

Abstract

A system includes a quantum source and an optical device coupled to the quantum source. The quantum source is configured to emit an entangled photon. The optical device is configured to route the entangled photon to one or more outputs. In some aspects, the optical device can include a photonic integrated circuit (PIC). Advantageously the system can provide a routing scheme to route (e.g., passively, actively, dynamically, or a combination thereof) entangled photons from one or more quantum sources (e.g., trapped ion, single-photon source, quantum emitter, etc.) between different nodes, a quantum frequency conversion scheme to match near-infrared photons (750 nm to 1260 nm) and/or telecommunication photons (1260 nm to 1675 nm) entangled with photons from one or more quantum sources to an operating wavelength of the optical device (e.g., PIC), programmable routing and entanglement distribution, and scalable long-distance quantum networks.

IPC Classes  ?

• H04B 10/70 - Photonic quantum communication
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

Disclosed herein are systems and methods for electrochemical recycling of lithium-ion batteries and components thereof. For example, in some embodiments, an electrochemical system is provided for the recovery of nickel, manganese, copper, lithium, and/or cobalt. In some embodiments, the system comprises one or more electrochemical cells, wherein each electrochemical cell comprises a working electrode and a counter electrode, the working electrode and counter electrode separated by a separator. In some embodiments, the systems described herein are configured for the simultaneous recovery of two or more metal (ions) for a given electrochemical cell. For example, in some embodiments, during operation of an electrochemical cell as described herein, cobalt and/or nickel may be deposited on a (working) electrode while manganese is deposited on a (counter) electrode. The systems and methods described herein may be particularly advantageous for the recovery of raw materials from spent lithium-ion batteries.

IPC Classes  ?

• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• H01M 8/04276 - Arrangements for managing the electrolyte stream, e.g. heat exchange

Abstract

The invention features compositions and methods for treating diseases or disorders associated with undesirable neuronal excitability (e.g., neurodegenerative disease, such as Parkinson's disease or Huntington's disease; or chronic pain, or epilepsy). The method comprises administering to a neuronal cell of the subject a vector comprising a mini Singlet Oxygen Generator (miniSOG) in the presence of monomers of 3,3'-diaminobenzidine or aniline and N phenyl p-phenylenediamine and irradiating at least a portion of the neuronal cell to induce polymerization of poly(3,3'-diaminobenzidine) or polyaniline.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 38/45 - Transferases (2)
• A61P 25/00 - Drugs for disorders of the nervous system
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/864 - Parvoviral vectors

Abstract

Photonics has benefited immensely from advanced silicon manufacturing. By leveraging mature complementary metal-oxide-semiconductor (CMOS) process nodes, unprecedented device uniformity and scalability have been achieved at low cost. However, some functionalities, such as optical memory, Pockels modulation, and magneto-optical activity, are challenging or impossible to provide with group-IV materials alone. Heterogeneous integration promises to expand the range of capabilities within silicon photonics. Unfortunately, existing heterogeneous integration protocols are incompatible with the active silicon processes offered at most photonic foundries. Here, we disclose a heterogeneous integration platform that enables wafer-scale, multi-material integration with active silicon-based photonics, with no change to the existing foundry process. Furthermore, this heterogeneous integration platform enables a class of high-performance devices, including: a grating coupler with peak coupling efficiency reaching 93%, an antenna with peak diffraction efficiency in excess of 97%, and a broadband adiabatic polarization rotator with conversion efficiency exceeding 99%.

IPC Classes  ?

• H01L 27/146 - Imager structures
• G02B 6/42 - Coupling light guides with opto-electronic elements
• G02B 6/43 - Arrangements comprising a plurality of opto-electronic elements and associated optical interconnections

Abstract

According to some embodiments, the cell culture system allows for the passage of cells in high-throughput cell culture applications. Unlike enzymatic detachment processes, the cell culture system, in some embodiments, limits any imparted damage onto the cell. Additionally, the lack of reliance on enzymes for cell detachments (e.g. trypsin) reduces and/or prevents the accrual of genetic mutations that can occur during enzymatic detachment processes. The cell culture system, in some embodiments, is capable of passaging and/or detaching cells at rates convenient for high throughput cell culturing and/or automated cell culturing regimes. Advantageously, the cell culture system, in certain embodiments, provides sufficient adhesion to promote cell growth and proliferation, but is capable of reducing the adhesion between the cell and the surface upon application of the electric field.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• B29C 35/02 - Heating or curing, e.g. crosslinking or vulcanising
• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances

Abstract

The present invention provides a system and method for detecting an analyte in a sample comprising semiconducting single-walled carbon nanotubes (SWCNTs) and surface- adsorbed nucleic acids, wherein the surface-adsorbed nucleic acids comprise a complementary region and at least one anchor, wherein the complementary region comprises a nucleic acid sequence that is complementary' to and/or hybridizes to a target region of the analyte, and the at least one anchor comprises a nucleic acid sequence that is not complementary' to the target region of the analyte.

IPC Classes  ?

• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

Compositions, articles, systems, and methods for detection of fluorocarbons are generally described. In certain embodiments, for example, a sensing material that comprises a coupled-multichromophore is described. The coupled-multichromophore may be capable of energy transport and/or diffusion between individual sites of the coupled-multichromophore. In certain embodiments, for example, the coupled-multichromophore comprises individual sites that arc linked through delocalized orbitals such that the coupled-multichromophore is capable of energy transport and/or diffusion through each individual site of the coupled-multichromophore. The sensing material comprising the coupled-multichromophore may be configured to detect the presence of an analyte, such as a fluoroalkyl species (e.g., a per- and/or polyfluoroalkyl substance). For example, in some embodiments, the coupled-multichromophore comprises at least one chromophore that displays a change in electromagnetic radiation (e.g., light) emission in response to a presence of the analyte. The change in electromagnetic radiation emission may be detected to determine the presence of the analyte.

IPC Classes  ?

• G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
• C09B 69/10 - Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
• G01N 33/18 - Water

Abstract

The present invention provides polymer compositions for use in cosmetic nail polish compositions. More particularly, the present disclosure relates to the introduction of cleavable conomoner additives into an existing polymer composition to produce a chemically deconstructable composition. Methods and compositions for removing the nail polish composition are also disclosed.

IPC Classes  ?

• A61K 8/04 - Dispersions; Emulsions
• A61K 8/18 - Cosmetics or similar toiletry preparations characterised by the composition
• A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
• A45D 29/00 - Manicuring or pedicuring implements
• A61Q 3/02 - Nail coatings

Abstract

Described are concepts, systems, methods, and machines for providing a device (e.g., electronic device) on a transferable, ultra-thin substrate. The described concepts, systems, methods, and machines may be used to produce an electronic device on a transferable, ultra-thin substrate using only solution-based (e.g., wet) processing techniques. The described concepts systems, methods, and machines may also be used to produce a releasable substrate for the electronic device having a certain desired characteristic. Structures including a device are also described. The structures may include the device, a releasable substrate, and a removable release liner carrier. Also described are systems, methods, and machines for removing a release liner carrier from a releasable substrate and device, for applying the releasable substrate and device to a permanent substrate, and for reusing the release liner carrier to produce another device.

IPC Classes  ?

• B32B 27/00 - Layered products essentially comprising synthetic resin
• B32B 27/36 - Layered products essentially comprising synthetic resin comprising polyesters
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
• C09K 3/00 - Materials not provided for elsewhere

Abstract

Described is an insulative layer for use in systems utilizing a high temperature superconductor (HTS). The insulative layer comprises a first layer of an insulative material, a second layer of an insulative material and a third layer of an electrically conductive material disposed the first and second layers. The electrically insulating material of the first layer and the electrically insulating material of the second layer are both resistant to grinding forces. The third layer is provided from a material having a resistance to oxidative degradation, weather, and radiation, as well as resistance to abrasive and fictional wear at cryogenic temperatures. In one application, the insulative layer may be disposed at an interface between a toroidal field (TF) coil and a central solenoid (CS) of a high temperature superconducting magnet.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H01F 27/36 - Electric or magnetic shields or screens
• G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
• G21B 1/11 - Thermonuclear fusion reactors - Details

Abstract

Techniques are described for improving quench damage resiliency in non-insulated (NI) high temperature superconductor (HTS) magnets. The techniques may include tuning an amount of HTS tape within turns of a winding of an NI-HTS magnet to reduce variation in critical current across the winding, and/or may include adjusting the turn-to-turn resistance of the windings by adjusting turn-to-turn spacing between windings and thereby reduce variations in joule heating between turns during a quench.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H01F 6/02 - Quenching; Protection arrangements during quenching
• G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement

Abstract

Disclosed herein is a method of forming a precipitate, comprising: a. providing a salt solution; b. performing electrochemical reactions in the salt solution to produce a solution of lower pH and a solution of higher pH; c. providing a silicate-containing material containing Mg2+ and/or Ca2+ ions; d. treating the silicate-containing material with the solution of lower pH to dissolve at least a portion of the silicate-containing material and generate a second solution with higher pH; e. combining the solution generated in (d) with at least a portion of the solution with higher pH generated in (b) to form the precipitate and a second salt solution; and f. recycling the second salt solution generated in step (e) by adding (b).

IPC Classes  ?

• C25B 15/08 - Supplying or removing reactants or electrolytes; Regeneration of electrolytes
• C01B 33/24 - Alkaline earth metal silicates
• C01F 11/12 - Oxides or hydroxides from silicates
• C01F 5/14 - Magnesium hydroxide
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 15/031 - Concentration pH
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms
• B01D 53/62 - Carbon oxides

Abstract

Devices, systems, and methods herein are generally directed to a robotic control system that comprises: a wearable robot comprising at least one actuated joint; at least one muscle-tendon interface configured to measure at least one physiological signal; a torque set point processor configured to receive the at least one physiological signal from the at least one muscle tendon interface and estimate a muscle-tendon state corresponding to a human motor intention and to compute at least one augmentation joint torque based on the muscle-tendon state; and a torque controller configured to apply the at least one augmentation joint torque to the at least one actuated joint of the wearable robot.

IPC Classes  ?

• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61F 2/50 - Prostheses not implantable in the body

Abstract

A system for desalinating water, the system comprising: a confined water layer, wherein the water layer is separated from the solar absorber by an air layer; a floating insulation below the confined water layer, wherein the floating insulation comprises a multiplicity of macro channels; a balancing weight, wherein the balancing weight is attached to the floating insulation and reduces buoyancy of the floating insulation in the confined water layer; and a bulk water layer, wherein the macro channels connect the bulk water to the confined water layer.

IPC Classes  ?

• C02F 1/14 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using solar energy
• C02F 1/08 - Thin film evaporation
• C02F 1/24 - Treatment of water, waste water, or sewage by flotation

Abstract

Hydrogen selective membranes and related methods are generally described. In some embodiments, a hydrogen selective membrane may exhibit high permeance and selectivity in comparison to conventional polymer membranes, at low material costs. The membrane may also be thermally and chemically stable at high operational temperatures. In some embodiments, the membrane may include a layer of inorganic material (e.g., palladium) and a layer of atomically thin material (e.g., graphene) arranged on a porous substrate. The inorganic material may be arranged in a film-like or an isolated island-type architecture. In other embodiments, the inorganic material may be arranged within the pores of the porous substrate in an isolated plug- type fashion.

IPC Classes  ?

• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B01D 69/10 - Supported membranes; Membrane supports
• B01D 71/02 - Inorganic material
• B01D 69/12 - Composite membranes; Ultra-thin membranes
• C01B 3/50 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification
• C01B 32/182 - Graphene
• C23C 16/342 -

Abstract

A micro-optical structure (200) for a micro-scale light source (202) having an emitting surface for emitting light is described. The micro-optical structure (200) comprises a reflective portion (204) formed on the emitting surface of the micro-scale light source, where the reflective portion (204) is adapted to reflect light emitted from the micro-scale light source (202) out of the micro-optical structure (200). A method for forming a micro-optical structure (200) is also described.

IPC Classes  ?

• H01L 33/60 - Reflective elements
• F21V 7/04 - Optical design

Abstract

A Floquet mode traveling wave parametric amplifier (TWPA) is disclosed. The Floquet mode TWPA comprises a plurality of stages, where each stage is made up of a nonlinear element and a shunt capacitor. The nonlinear elements may be Josephson junctions, or a combination of series and/or parallel Josephson junctions. The Floquet mode TWPA is designed such that the critical current of the nonlinear elements in each stage is not constant. In some embodiments, the ratio of the largest critical current to the smallest critical current in the Floquet mode TWPA is at least 2:1. In some embodiments, the nonlinear elements with the largest critical current are disposed at or near the input or output of the amplifier. In this way, reflections and backward amplification may be minimized. Further, the TWPA is formed using planar capacitors on a high resistivity substrate, or using low loss parallel plate capacitors.

IPC Classes  ?

• H03F 19/00 - Amplifiers using superconductivity effects
• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
• H03F 7/00 - Parametric amplifiers
• H01B 12/02 - Superconductive or hyperconductive conductors, cables or transmission lines characterised by their form

Abstract

Embodiments of the present disclosure are directed towards a heterogenous catalyst composition of formed from using a crystalline porous metal-organic framework (MOF) which reacts in an inverse electron-demand Diels-Alder reaction with a phosphorous ligand to produce a heterogeneous catalyst precursor. The heterogeneous catalyst precursor then reacts with a Group VIII transition metal catalyst precursor compound to form the heterogeneous catalyst composition that can be used for the hydroformylation of olefins, among other reactions.

IPC Classes  ?

• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
• B01J 31/24 - Phosphines
• C07C 47/02 - Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen

Abstract

Methods of controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes (ISCOMs) are described. The methods involve mixing one or more saponins, one or more lipids, one or more sterols, one or more additional adjuvants (e.g., TLR4 agonist), and optionally one or more antigens in the presence of a detergent. Typically, the mixing step is followed by an incubation step, a dilution and/or concentration step, and/or a filtration or dialysis step for removing detergent. Preferably, methods involve a tangential flow filtration (TFF) process suitable for scalable synthesis and Good Manufacturing Practice (GMP) production of highly homogeneous clinical-grade ISCOM-based adjuvants.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/127 - Liposomes
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• B82Y 40/00 - Manufacture or treatment of nanostructures
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Compositions and methods for increasing delivery of antigen to B cell follicles are provided. The compositions typically include an antigen and a CD35, FDC-M1, FDC-M2, fixative-resistant antigen, FDCSP, CD21, C4, MFG-E8, CD21, or FC receptor binding moiety that are linked or otherwise conjugated to form a binding moiety-antigen molecule or conjugate. Typically, the antigen and binding moieties are polypeptides and in preferred embodiments, the binding moiety-antigen is a fusion protein. The binding moiety is preferably an antibody that specifically binds to CD35, preferably an scFv. The antigen can be derived from, for example, a virus, bacterium, parasite, plant, protozoan, fungus, tissue or transformed cell such as a cancer. Pharmaceutical compositions including the binding moiety-antigen or a nucleic acid encoding the same, and optionally an adjuvant are also provided, as are methods of using the compositions for increasing an immune response in a subject in need thereof.

IPC Classes  ?

• C07K 16/46 - Hybrid immunoglobulins
• A61K 39/12 - Viral antigens
• A61P 31/12 - Antivirals

Abstract

In certain aspects, provided herein are mutant stimulator of interferon genes (STING) polypeptides, compositions thereof and methods of using the same, wherein the mutation is within the dimerization interface of the STING, and wherein the mutation reduces the ability of the mutant STING polypeptide to mediate protein leakage across a membrane compared to a wild-type STING polypeptide.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals

Abstract

Described herein is a method for depositing a two-dimensional material film on a substrate. In some embodiments, the method comprises using a reactor with two regions to decompose the first precursor. In some embodiments, the method comprises using a higher temperature region to help or accelerate the decomposition of the precursors. In some embodiments, the method comprises placing one or more substrates into the lower temperature region, wherein the temperature will not be high enough to damage the substrate or its nanostructures. In some embodiments, the method comprises depositing a two-dimensional material film and fabricating two-dimensional material devices and circuits at the back end of silicon CMOS circuits.

IPC Classes  ?

• C23C 16/44 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating
• C23C 16/18 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the deposition of metallic material from metallo-organic compounds
• C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
• C23C 16/02 - Pretreatment of the material to be coated
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

Disclosed are nucleic acids encoding fusion proteins containing a target binding domain, a cleavage domain cleavable by A Disintegrin and Metalloproteinase (ADAM) 17, and a transmembrane domain.

IPC Classes  ?

• C07K 14/735 - Fc receptors
• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• C07K 19/00 - Hybrid peptides
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents

Abstract

A method for remote intervention for a subject includes acquiring an image of a region of interest of the subject using an interventional device positioned on the subject and an image acquisition system. The region of interest includes a target structure and the subject is located at a first site. The method further includes analyzing the acquired image using an image analysis module to identify and label the target structure in the region of interest and transmitting the labelled image from the first site to a second site for expert review. The second site is remote from the first site. The method further includes receiving a command signal at the first site from the second site where the command signal is generated based on the expert review of the labelled image and configured to control an action of the interventional device. In some embodiments, the method may further include analyzing the acquired image to determine a pathway to the vessel that avoids critical structures.

IPC Classes  ?

• A61B 34/35 - Surgical robots for telesurgery
• A61B 34/37 - Master-slave robots
• A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 17/34 - Trocars; Puncturing needles
• A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints

Abstract

The present disclosure is directed to miniature high-temperature ultrasound probes. A device comprising a high temperature piezo-element is disclosed, which is encapsulated within highly anti-oxidizing and non-corrosive electrodes and has been tested within a high temperature- high pressure system to check the performance of the device. Although the disclosed embodiments are suitable for use in a high temperature ultrasound transducer array, the detailed high temperature-design disclosed herein is not limited to monitoring acoustic emissions and conducting active probes (phase arrival) but can be employed also as pressure (load) sensors if the sensor is characterized and calibrated for a working load and temperature interval.

IPC Classes  ?

• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object - Details
• G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices

Abstract

An upconversion film or device includes a dielectric layer, a gap electrode layer overlying the dielectric layer, and an upconversion material configured to upconvert infrared light to visible light. The gap electrode layer includes an array of discrete apertures between an array of discrete electrodes and a continuous electrode. Each discrete aperture is defined by a capacitive gap at least partially filled by the upconversion material, An example upconversion film includes capacitive gaps that are each less than 20 nanometers. An example upconversion device includes an optically transparent electrode layer underlying the dielectric layer. An example infrared camera includes an imaging layer that includes an array of sensing elements, in which each discrete aperture is aligned with a sensing element. An example method of manufacturing an upconversion film includes forming a passivation layer on the array of discrete electrodes using atomic layer deposition to form the capacitive gap.

IPC Classes  ?

• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• G01J 5/20 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using resistors, thermistors or semiconductors sensitive to radiation, e.g. photoconductive devices
• H01L 31/02 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof - Details
• H01L 31/055 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means where light is absorbed and re-emitted at a different wavelength by the optical element directly associated or integrated with the PV cell, e.g. by using luminescent material, fluorescent concentrators or up-conversion arrangements

Abstract

Propulsion　systems,　methods　and　aircraft　related　to　boundary　layer　ingestion　are　described.　In　some　embodiments,　an　aircraft　may　include　a　fuselage　with　a　plurality　of　boundary　layer　ingesting　propulsors　may　be　disposed　on　and　distributed　around　at　least　a　portion　of　a　5　perimeter　of　the　fuselage.　An　annular　exit　nozzle　may　be　fluidly　coupled　to　a　plurality　of　propulsor　outlets　of　the　plurality　of　propulsors　such　that　an　outflow　from　the　plurality　of　propulsors　flows　through　the　annular　exit　nozzle　during　operation　of　the　aircraft.　In　other　embodiments,　a　boundary　layer　ingesting　propulsor　may　be　disposed　on　the　fuselage　where　a　portion　of　the　fuselage　upstream　from　the　inlet　may　be　configured　to　provide　a　desired　Mach　10　number　for　fluid　located　within　a　predetermined　distance　of　the　propulsor　inlet　during　cruise　of　the　aircraft.

IPC Classes  ?

• B64C 21/01 - Boundary layer ingestion [BLI] propulsion
• B64D 27/20 - Aircraft characterised by the type or position of power plant of jet type within, or attached to, fuselage

Abstract

Dissolution of a gas in a liquid medium and/or reaction of a gas with one or more components within a liquid medium using a variety of articles, systems, and methods is generally described.

IPC Classes  ?

• B01J 8/22 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium gas being introduced into the liquid
• B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• B32B 3/30 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
• B05D 5/08 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface

Abstract

22322 precipitate phases comprises at least one of erbium and zirconium. This alloy and other compositions as well as the processing conditions for producing the compositions can be formulated via a computer-implemented method involving evaluation of material properties of simulated products formed from a plurality of precursor compositions.

IPC Classes  ?

• C22C 1/02 - Making non-ferrous alloys by melting
• C22F 1/04 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of aluminium or alloys based thereon
• C22C 1/04 - Making non-ferrous alloys by powder metallurgy

Abstract

Methods for correcting errors arising in correlated received multi-symbol data by guessing noise effects at a receiver device are disclosed. In various embodiments, the ordering of symbol-level noise effects is informed by correlated soft information. A lattice of possible joint combinations of interfering symbols and/or symbols impacted by correlated noise is constructed. Then, determining a decoded codeword includes iteratively guessing new noise effects expressed as a set of lattice-point substitutions over a multi¬ symbol data block, and checking whether the data associated with the resultant lattice points form a codeword using a codebook membership function. In some embodiments, the decoder is restricted to testing a constrained collection number of lattice points and can abandon searching and declaring an erasure.

IPC Classes  ?

• H03M 13/37 - Decoding methods or techniques, not specific to the particular type of coding provided for in groups
• H03M 13/45 - Soft decoding, i.e. using symbol reliability information

Abstract

According to one embodiment, a power amplifier includes a plurality of switches and an output tank network. One or more of the switches are configured to generate one or more first intermediate waveforms having one or more first fundamental frequency components, and one or more of the switches are configured to generate one or more second intermediate waveforms by chopping the one or more first intermediate waveforms with controllable timing. The second intermediate waveforms have one or more second fundamental frequency components that are controllably reduced from those of the one or more first intermediate waveforms. The output tank network is configured to filter the one or more second intermediate waveforms to provide an output waveform to a load, the output waveform having one or more third fundamental frequency components. In some cases, all switches achieve zero voltage switching under different power and load conditions with resistive and reactive loads.

IPC Classes  ?

• H03F 3/24 - Power amplifiers, e.g. Class B amplifiers, Class C amplifiers of transmitter output stages
• H04L 25/08 - Modifications for reducing interference; Modifications for reducing effects due to line faults
• H04L 25/12 - Compensating for variations in line impedance

Abstract

The present invention relates to a method for preparing a macroscopic composite fiber comprising at least one coordination structure and an alginate, to a fiber obtained according to said method, and to uses thereof as a gas adsorbent as well as in the field of heterogeneous catalysis, filtration, photonics, or superradiance.

IPC Classes  ?

• D01F 9/04 - Man-made filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of alginates
• D01F 1/10 - Other agents for modifying properties
• D01D 5/06 - Wet spinning methods

Abstract

Machine learning methods and systems for detecting sample contamination are disclosed. The methods comprise: receiving sequencing data of a sample, the sequencing data comprises a plurality of sequence reads; metagenomically classifying sequence reads of the plurality of sequence reads against a contaminant database to obtain metagenomic classification data; generating a feature set using the metagenomic classification data; and classifying a contamination status of the sample by inputting the feature set into a machine learning classifier.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

A method includes receiving data characterizing a number of documents, including data associating each document with a number of utility scores. Each utility score characterizes a different type of utility of the document to a consumer of the document. A subset of the documents is selected for presentation to a user, the selecting being based at least in part on the respective utility scores associated with each of the documents and the subset of documents is provided for presentation to the user.

IPC Classes  ?

• G06F 16/951 - Indexing; Web crawling techniques
• G06F 16/9535 - Search customisation based on user profiles and personalisation

Abstract

e.g.e.g., polyethylene and various derivatives thereof) and/or other fully-recyclable materials. The performance of the resulting yarns is on par with, if not better than, existing yarns, fabrics, and fibers with respect to tenacity, elasticity, and auxetic performance. As a result, textiles can be made from the yarns, and then the textiles themselves can be fully recyclable such that the textile can be recycled and then a new textile can be formed from the same materials of the old textile. Methods of formulating the yarns and textiles are also provided.

IPC Classes  ?

• D02G 3/36 - Cored or coated yarns or threads
• D02G 3/32 - Elastic yarns or threads
• D02G 3/38 - Threads in which fibres, filaments, or yarns are wound with other yarns or filaments

Abstract

Laser-reduction of polymers has recently been explored to rapidly and inexpensively synthesize high-quality graphitic and carbonaceous materials from commercial polymers. Such easily synthesizable carbonaceous structures hold promise in being utilized for a broad range of electrochemical applications, including in energy storage. However, in past work, laser induced graphene has been restricted to semi-aromatic polymers and graphene oxide - in particular, poly(acrylonitrile) (PAN) is claimed to be a polymer that cannot be laser-reduced successfully to form electrochemically-active material. In this work, three strategies to surmount this barrier are employed: (1) thermal stabilization of PAN (resulting in thermally stabilized PAN (TS-PAN)) to increase its sp2 Content for improved laser processability, (2) prelaser treatment microstructuring to reduce the effects of thermal stresses, and (3) Bayesian Optimization to search the parameter space of laser processing to improve performance and discover new morphologies.

IPC Classes  ?

• B01D 71/42 - Polymers of nitriles, e.g. polyacrylonitrile
• B01D 69/12 - Composite membranes; Ultra-thin membranes
• C01B 32/184 - Preparation
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals

Abstract

Techniques are described that allow for HTS cables to be solder-filled more easily, quickly, and with a reduced degradation to the performance of the HTS in the cable. In particular, a channel within an HTS cable may include a primary channel into which the HTS is arranged, in addition to a secondary channel that provides an increased hydraulic cross-section through which the solder can flow. The secondary channel may be connected to the primary channel (e.g., as a side-channel). If the secondary channel has an opening within the primary channel that is smaller than the HTS material being placed in the primary channel, the HTS material is not at risk of moving into the secondary channel, which can provide a space proximate to the HTS material and the primary channel through which the solder can freely flow.

IPC Classes  ?

• H01B 12/06 - Films or wires on bases or cores
• H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils

Abstract

Devices and methods for controlling a phase transition of a sample are provided. The device includes a heat transfer device adapted to be thermally connected with a sample, where the sample has a first phase and a second phase, with the sample being initially in the first phase; an image acquisition module adapted to acquire an image of the sample; and a control system, operably connected to the heat transfer device and the image acquisition module. The control system is configured to, while a termination condition is not met: cause heat transfer between the heat transfer device and the sample, thereby causing a phase transition of the sample from the first phase to the second phase; cause the acquisition module to acquire the image of the sample; based on the image of the sample, determine the position of a boundary between the first phase and the second phase of the sample; and based on the determined position of the boundary, determine whether the termination condition is met.

IPC Classes  ?

• G05D 23/27 - Control of temperature characterised by the use of electric means with sensing element responsive to radiation
• A01N 1/02 - Preservation of living parts
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• F25B 49/00 - Arrangement or mounting of control or safety devices
• G01N 25/00 - Investigating or analysing materials by the use of thermal means

Abstract

Systems, devices, and methods for measuring the dynamic properties of metamaterials at the microscale are provided. For example, laser-induced resonant acoustic spectroscopy (LIRAS) can be used as a non-destructive and/or non-contact optical framework within a material of interest to measure photoacoustic excitation of elastic waves. The system can include a pulsed-laser-based mechanical characterization technique that emits lasers at the sample of interest from various directions to demonstrate a high-throughput non-contact framework that employs MHz-wave propagation signatures to create a vibrational response. The vibrational response of the sample of interest can be used to extract dynamic mechanical properties thereof, such as omnidirectional elastic information, damping properties, and defect quantification. In some embodiments, the LIRAS technique can be employed in a characterization module within an additive manufacturing system to measure parameters of printed parts.

IPC Classes  ?

• G01N 29/24 - Probes
• B22F 12/90 - Means for process control, e.g. cameras or sensors
• B33Y 50/00 - Data acquisition or data processing for additive manufacturing
• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

Abstract

It is an object of the present invention to provide a lipid composition capable of delivering a nucleic acid such as RNA to a hematopoietic stem/progenitor cell or mesenchymal stem cells, and a method of delivering a therapeutic agent to a cell using the lipid composition. The present invention provides a lipid composition comprising (A) a therapeutic agent and (B) a lipid nanoparticle conjugated to a targeting molecule, wherein the lipid nanoparticle comprises an ionizable lipid, and the targeting molecule specifically binds to a marker of hematopoietic stem / progenitor cells or mesenchymal stem cells.

IPC Classes  ?

• A61K 47/42 - Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
• A61K 9/10 - Dispersions; Emulsions
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 9/10 - Transferases (2.)
• C12N 9/22 - Ribonucleases
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Abstract

Systems and methods related to drug delivery are provided. In one arrangement, a fluid is administered to a subject in drinkable form, which can partially or fully solidify in the stomach or another area of the gastrointestinal tract to form a drug release article or composition.

IPC Classes  ?

• A61K 9/06 - Ointments; Bases therefor
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/02 - Inorganic compounds
• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine

Abstract

A method can include providing a first neural network connected to a second neural network. The first neural network can represent B+11 and the second neural network can represent electrical properties. The method can include training the first neural network and the second neural network jointly. The method can include determining, from the trained first neural network and the trained second neural network B+11, a prediction of and electrical properties at one or more predetermined locations. The method can include outputting the prediction of B+11 and EP.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation
• G06N 3/045 - Combinations of networks
• A61B 5/311 - Input circuits therefor specially adapted for particular uses for nerve conduction study [NCS]
• G01R 33/44 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]

Abstract

Disclosed are methods for fabricating a porosity gradient electrode. Also disclosed are porous electrodes. In this process, a single-phase mixture of scaffold-forming polymers dissolved in a solvent is driven into two-phases by a non-solvent, yielding a scaffold which can subsequently be thermally annealed into a carbonaceous and electrochemically active material.

IPC Classes  ?

• H01M 4/88 - Processes of manufacture
• H01M 4/04 - Processes of manufacture in general

Abstract

Aspects of the disclosure relate to reagents, compositions, kits, and methods associated with liposome-mediated delivers7 of cargo in response to an environmental trigger. Some aspects of the present invention relate to treating a diseased cell, tissue, or organ using the reagents.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
• A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Abstract

Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
• C12N 9/10 - Transferases (2.)
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

Disclosed herein are methods, compositions, systems, and kits related to functional testing of polypeptide-target interactions, such as antigen/immune receptor interactions, in a single-cell format.

IPC Classes  ?

• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/566 - Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagent
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
• C12N 5/09 - Tumour cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

Abstract

A Rogowski-style current sensor includes a twisted pair of wires or cables formed into a coil. A second coil formed from another pair of wires or cables, twisted in the opposite direction, may be placed alongside, but not necessarily immediately adjacent to, the first coil, and the signals from each twisted pair may be added or subtracted to measure the enclosed current or a diamagnetism. When the current to be measured is a plasma current in a tokamak, the current sensor may be placed behind shielding tiles on the inner wall of a vacuum vessel that contains the plasma. Another current sensor may be placed on an external wall of the vacuum vessel, and the outputs subtracted to measure a current flowing through only the vessel itself.

IPC Classes  ?

• G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof

Abstract

A reactor system and method for oxidizing methane can include an environmentally friendly catalyst material that converts methane to an oxidized product at low temperatures and concentrations, for example, to reduce or eliminate methane in coal mine air, dairy barns, oil and gas fields, and direct air conversion applications.

IPC Classes  ?

• B01D 53/86 - Catalytic processes
• F23C 13/08 - Apparatus in which combustion takes place in the presence of catalytic material characterised by the catalytic material
• F23G 5/50 - Control or safety arrangements
• F23G 7/07 - Methods or apparatus, e.g. incinerators, specially adapted for combustion of specific waste or low grade fuels, e.g. chemicals of waste gases or noxious gases, e.g. exhaust gases in which combustion takes place in the presence of catalytic material
• B01D 53/94 - Chemical or biological purification of waste gases of engine exhaust gases by catalytic processes

Abstract

Method and system wherein induced pluripotent stem cells quality and differentiation are evaluated using T2 magnetic resonance relaxometry.

IPC Classes  ?

• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• G01R 33/44 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
• C12N 5/0735 - Embryonic stem cells; Embryonic germ cells
• G01R 33/30 - Sample handling arrangements, e.g. sample cells, spinning mechanisms