Systems and methods for rapid diagnostics related to the use of combinations of CRISPR effector systems with optimized guide sequences, OSD probes, RNA probes and/or RNase H for detection of nucleic acid sequences, such as sequences from coronavirus, as well as multiplex lateral flow diagnostic devices and methods of use, are provided.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
A method of forming an active self-transformable material includes providing a flexible base material and disposing an active material on one or more surfaces of the flexible base material or within the flexible base material in a specific pattern to form a combined structure having a natural shape, wherein the active material is a material that is reactive to exposure to an external stimulus trigger, wherein the flexible base material is non-reactive to the external stimulus trigger, minimally reactive to the external stimulus trigger, or reactive to the external stimulus trigger differently than the active material, and wherein exposure of at least a portion of the specific pattern of the active material to the external stimulus trigger changes the shape of the combined structure from the natural shape into a predetermined 3-dimensional transformed shape.
D06M 15/19 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials with macromolecular compounds; Such treatment combined with mechanical treatment with synthetic macromolecular compounds
B32B 3/10 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 5/18 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
D06M 15/227 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of hydrocarbons, or reaction products thereof, e.g. afterhalogenated or sulfochlorinated
D06M 15/256 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of halogenated hydrocarbons containing fluorine
Described herein is a chemical process for the conversion of lignocellulosic biomass into muconic acid which is useful for the generation of plastics and polymers. The described methods utilize catalytic chemical reactions and biological processes to facilitate the conversion, while increasing yields and reducing energy requirements.
H03H 9/17 - Constructional features of resonators consisting of piezoelectric or electrostrictive material having a single resonator
H03H 3/02 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of piezoelectric or electrostrictive resonators or networks
Described herein is a carbon-efficient bicarbonate electrolyzer and assembly. In some embodiments, an electrolyzer assembly comprises: a cathode disposed in a cathode chamber having ports for receiving a bicarbonate (HCO3−) solution; an anode disposed in an anode chamber having ports for receiving an anolyte; a cation exchange membrane disposed between the cathode chamber and the anode chamber; and a buffer layer disposed between the cathode chamber and the cation exchange membrane. In some embodiments, the electrolyzer assembly is configured to convert the bicarbonate (HCO3−) solution to a formate (OOCH−) solution by movement of cations from the anode to the cathode via the cation exchange membrane.
C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
C25B 13/02 - Diaphragms; Spacing elements characterised by shape or form
C25B 13/05 - Diaphragms; Spacing elements characterised by the material based on inorganic materials
C25B 15/08 - Supplying or removing reactants or electrolytes; Regeneration of electrolytes
6.
IN SITU EXPANSION OF ENGINEERED DEVICES FOR REGENERATION
Engineered human tissue seed construct are provided that are suitable for implantation in subjects. Methods of making and using the engineered tissue seed constructs are provided.
Described herein are methods for the generation of cyclic alkanes, useful as sustainable aviation fuel, from sustainable biomass sources. The described methods utilize Diels-Alder reaction followed by hydrogenation to generate the desired compounds from lignocellulosic biomass.
C07C 1/20 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms
C07C 5/03 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of non-aromatic carbon-to-carbon double bonds
C10L 1/06 - Liquid carbonaceous fuels essentially based on blends of hydrocarbons for spark ignition
8.
HYBRID QUANTUM SENSORS BASED ON SPIN DEFECTS COUPLED TO AN ARRAY OF SINGLE MOLECULE MAGNETIC CENTERS
Hybrid quantum sensors are provided. In some aspects, a hybrid quantum sensor comprises a first layer of diamond having multiple nitrogen-vacancy defect centers; and a second layer overlaying the first layer. The second layer forms a planar interface with the first layer, and includes at least one paramagnetic metal phthalocyanine. The at least one paramagnetic metal phthalocyanine comprises at least one transition metal.
Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements.
An article of manufacture includes a set of three-dimensional elements, each having has a same size and the same shape, with at least three distinct faces on which content is provided. A first face on an element is a title page or a title face with text. The text represents certain hierarchical subject matter including a topic within a category. A second face is an icon page or an icon face with an icon, such as a graphic or line drawing. By being general, the icon provokes imagination beyond the topic expressed by the text. A third face is an image page or an image face with a photorealistic image of a scene, which may be a photographic image or computer-generated. On any given element, both the subject matter represented by the respective icon on that element and the subject matter represented by the respective image on that element are relevant to the topic represented by the respective text on that element.
A method for generating a visual representation of an environment based on a point cloud includes hierarchically processing the point cloud with different granularity levels to generate multiple groups of primitives and multiple sets of points. The method also includes generating a group of intermediate sets associated with the point cloud, each intermediate set associated with one of the multiple groups of primitives and one of the multiple sets of points, having a same granularity level. The method further includes iteratively determining respective features associated with each intermediate set of a sequence of intermediate sets, each intermediate set included the set of primitives and the set of points, the respective features including first features of the set of primitives and second features of the set of points. The method still further includes generating the visual representation based on the respective features of each one of the sequence of intermediate sets.
Described are structures and techniques for providing high-efficiency. high-power-density piezoelectric resonators (PRs) for use in power converters. In some embodiments. a power converter can include a PR for energy transfer. where the PR substantially satisfies geometry conditions disclosed herein for achieving high-efficiency and high-power-density. The geometry conditions can be defined in terms of the converter's specified (e.g., rated) voltage and power level.
Provided herein are methods of selectively delivering an agent to a cell, comprising contacting the cell with a composition comprising an agent and lipids selected from: (a) an ionizable amino lipid, (b) a sterol, (c) a phospholipid, and (d) a PEG-lipid. The methods are selective for delivery to microglia over other neuroglia, such as astrocytes.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
14.
SYSTEMS, METHODS, AND COMPOSITIONS COMPRISING MINIATURE CRISPR NUCLEASES FOR GENE EDITING AND PROGRAMMABLE GENE ACTIVATION AND INHIBITION
This disclosure provides systems, methods, and compositions comprising miniature CRISPR. nucleases for gene editing and programmable gene activation and inhibition. The miniature CRISPR nuclease is a target specific nuclease having a compact structure with a small number of amino acids. The target specific nuclease targets DNA and is directed to a target nucleic acid sequence from the DNA by a guide RNA. In some embodiments, the target specific nuclease exhibits DNA cleavage activity and is directed by a gRNA to a target nucleic acid sequence from a DNA. In some embodiments, the target specific nuclease does not exhibit DNA cleavage activity and is directed by a gRNA to a target nucleic acid sequence from a DNA.
The present disclosure relates to electrochemical target species (e.g., carbon dioxide) capture and release with a redox-active amine. Associated systems and articles are also described.
B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
16.
CYBER-SECURE DYNAMIC MONITORING AND DECISION SYSTEMS
Systems and methods for detecting cyber attacks of subsystems include an interface of the subsystem that provides power exchange. A processor may be configured to calculate an interaction variable from a function of one or more internal states of the subsystem. A comparator circuit is coupled to receive the output signal and the interaction variable, to determine a difference between at least one characteristic of the power signal and at least one characteristic of the interaction variable. A cyber-attack identification module is configured to identify the presence of a cyber-attack targeting the system based on the difference between the at least one characteristic of the power signal and the at least one characteristic of the interaction variable.
H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the network; Circuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
17.
SOFT HAND WITH ENDOSKELETON AND HIGH RESOLUTION SENSING
A robotic finger may include a first endoskeleton segment, a second endoskeleton segment, and a flexure connecting the first endoskeleton segment and the second endoskeleton segment, where the flexure is configured to elastically deform to allow the first endoskeleton segment to move relative to the second endoskeleton segment in a first degree of freedom. The robotic finger may include a transparent elastomeric pad disposed on the first endoskeleton segment and the second endoskeleton segment, at least one light source disposed on at least one of the first endoskeleton segment and the second endoskeleton segment, and at least one photosensitive detector disposed on at least one of the first endoskeleton segment and the second endoskeleton segment.
Electrochemical conversion of a species into a carbonate-containing compound, or other compounds, from seawater or other aqueous environments is generally described.
The invention relates to compositions and methods for targeting polynucleotides with eukaryotic RNA-guided nucleases. In particular, programmable RNA-guided DNA endonucleases termed Fanzors, can be harnessed for genome editing.
Embodiments generate and train an optimized demand model for predicting a demand of an item. Embodiments receive a plurality of trees, each of the plurality of trees including one or more levels of splits and a plurality of nodes, each of the plurality of nodes corresponding to a demand feature that influences demand for the item. Embodiments store a first bound as a current bound for each of the plurality of trees. Starting at a top split of each of the plurality of trees, embodiments select a first demand feature that a greatest number of the plurality of trees split on. Embodiments optimize the first demand feature using the stored current bound to generate a second bound. Embodiments store the second bound as the current bound for each of the plurality of trees and move down each of the plurality of trees to a next level of splits.
A power generator includes a plurality of amplifier blocks and a combiner. Each of the amplifier blocks include one or more amplifiers, and the combiner combines modulated power signals output from the amplifier blocks to generate an RF power signal of a load. The amplifier blocks are controlled to outphase the modulated power signals based on a phase angle. Ones of the amplifier blocks may perform discrete modulation to generate a respective one of the modulated power signals. The discrete modulation includes selecting different combinations of the amplifiers in one or more of the amplifier blocks to change the RF power signal in discrete steps. In embodiments, the amplifiers may be radio frequency power amplifiers.
Technion Research & Development Foundation Limited (Israel)
Inventor
Soljacic, Marin
Kaminer, Ido
Rivera, Nicholas
Sloan, Jamison
Salamin, Yannick
Abstract
A principle which enables the generation of macroscopic Fock and sub-Poissonian states is disclosed. Generic components of the system include: an electromagnetic structure (possessing one or more electromagnetic resonances), a nonlinear electromagnetic element (such as a nonlinear crystal near or inside the structure), and a source of light. In one embodiment, stimulated gain is used to create large numbers of photons in a cavity, but with very low photon number noise (uncertainty) in the cavity, and thus acts as a Fock laser. This Fock laser is capable of producing these states due to a very sharp intensity-dependent gain (or loss) that selects a particular photon number. The disclosed system and method are robust against both atomic and optical decoherence. Various examples of the new Fock laser design are also described.
Disclosed herein are articles, systems, and methods for the injection of viscous fluids. For example, inventive articles, systems, and methods for injecting viscous fluids, such as concentrated drug formulations, via droplet lubrication are described.
Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.
C07C 29/44 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon double or triple bond
B01J 23/46 - Ruthenium, rhodium, osmium or iridium
C07C 29/16 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxo-reaction combined with reduction
C07C 31/12 - Monohydroxylic acyclic alcohols containing four carbon atoms
C07C 31/125 - Monohydroxylic acyclic alcohols containing five to twenty-two carbon atoms
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
The present disclosure provides cyclic silyl ethers of the formula:
The present disclosure provides cyclic silyl ethers of the formula:
The present disclosure provides cyclic silyl ethers of the formula:
and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.
C07F 7/08 - Compounds having one or more C—Si linkages
A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C08G 61/06 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds
C08L 79/08 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
The present disclosure provides methods and systems for profiling RNAs being translated in a cell. Also provided by the present disclosure are methods for diagnosing a disease or disorder in a subject based on a profile of the RNAs being translated in a cell, including cells within an intact tissue. Methods of screening for or testing a candidate agent capable of modulating translation of one or more RNAs are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder in a subject in need thereof. Pairs of probes and sets of probes comprising oligonuclcotide portions, which may be useful for performing the methods described herein, are also described by the present disclosure. Additionally, the present disclosure provides kits comprising any of the probes described herein.
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c:
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c:
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c:
or a pharmaceutically acceptable salt thereof.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
29.
SYSTEM AND METHOD FOR PARALLEL IMPLEMENTATION OF MULTI-QUBIT QUANTUM GATES
A device includes a grouping of N qubits, where N is equal to two or more, and a coherent light source configured to, given selected values for a set of parameters of at least a first and a second laser pulse, the parameters selected from a relative phase shift, a laser frequency, a laser intensity, and a pulse duration: apply at least the first and second laser pulses to all qubits within the grouping of N qubits, thereby coupling a non-interacting quantum state |1 to an interacting excited state |r, such that each qubit that begins in quantum state |1 returns to the state |1 upon completion of the at least first and second laser pulses, and such that qubits in the grouping are mutually blockaded.
Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/00 - Medicinal preparations characterised by special physical form
A method for remote intervention for a subject includes acquiring an image of a region of interest of the subject using an interventional device positioned on the subject and an image acquisition system. The region of interest includes a target structure and the subject is located at a first site. The method further includes analyzing the acquired image using an image analysis module to identify and label the target structure in the region of interest and transmitting the labelled image from the first site to a second site for expert review. The second site is remote from the first site. The method further includes receiving a command signal at the first site from the second site where the command signal is generated based on the expert review of the labelled image and configured to control an action of the interventional device. In some embodiments, the method may further include analyzing the acquired image to determine a pathway to the vessel that avoids critical structures.
Aspects of this disclosure provide compositions, strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. Fusion proteins capable of inducing a cytosine (C) to guanine (G) change (i.e., transversion changes) in a nucleic acid (e.g., genomic DNA) are provided. Fusion proteins of a nucleic acid programmable DNA binding protein (e.g., Cas9) and nucleic acid editing proteins or protein domains, e.g., deaminase domains, polymerase domains, base excision enzymes, and/or DNA repair proteins, are also provided. Methods for targeted nucleic acid editing are also provided. Reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of a nucleic acid programmable DNA binding protein (e.g., Cas9), and nucleic acid editing proteins or domains, are further provided in the present disclosure.
C07K 14/35 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
The present disclosure provides, in various aspects, engineered alcohol tolerant yeast and methods of producing high concentrations of biofuels and bioplastics from toxic feedstocks.
Techniques described herein relate to systems and methods for obtaining a high temperature superconducting (HTS) cable assembly and filling the HTS cable assembly with a molten metal, such as solder.
There is provided an apparatus for a cellulose-based vertical flow assay, the apparatus comprising: a holder for supporting a cellulose substrate having a plurality of test zones thereon, the holder having a base plate and engaging members; and a lid for reversibly engaging with the engaging members of the holder such that when engaged, the lid is disposed over the base plate and a gap exists between the lid and the base plate, wherein the lid comprises a plurality of openings for allowing access to the test zones on the cellulose substrate. Also provided are related methods.
Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided.
Die-to-die electrical interconnects, optical couplers, and related methods for electronic and photonic co-packaging are described. Optical couplers include multi-segmented tapered waveguide core segments, slotted core segments, and graded refractive index structures to significantly relax alignment tolerances between dies. Conductive nanopillars, conductive pads, and conductive micropillars can be used to make electrical connections between circuitry on the interconnected dies. The electrical connections can be used to self-align the optical couplers between the dies. Due to relaxed optical alignment tolerances, electrical interconnects and optical coupling between dies can be made in the same die-to-die bonding step.
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
G02B 6/12 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
39.
SENSORS FOR DETECTING AND IMAGING OF CANCER METASTASIS
In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of cancer. In some embodiments, the disclosure relates to protease imaging sensors comprising a scaffold linked to an enzyme-specific substrate that includes a first detectable marker capable of being released from the prostate protease sensor when exposed to an enzyme present in cancer and a tumor imaging agent comprising a second detectable marker that is linked to the scaffold. In some embodiments, the disclosure relates to methods of monitor progression of a tumor in a subject based upon detection of detectable markers in a sample obtained from a subject who has been administered a protease imaging sensor, upon detection of a tumor imaging agent, or any combination thereof.
Disclosed herein are modified niRNAs and modified non-coding RNAs with poly(A) tails containing modified nucleotides and/or secondary structures, which may be made by ligation of a tailing nucleic acid onto the 3′ terminal end of an RNA. Also provided are compositions comprising one or more modified mRNAs or modified non-coding RNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
In certain aspects, a computer-implemented method includes generating a candidate structure based on constituent elements and a target behavior. The method includes simulating, in a prespecified environment, behavior of the candidate structure under prespecified constraints. The method includes evaluating the behavior of the candidate structure, during the simulating, under the prespecified constraints. The method includes calculating a gradient of the behavior of the candidate structure simulated under the prespecified constraints with respect to parameters associated with the constituent elements. The method includes optimally adjusting, based on the calculated gradient, the parameters for improving the behavior of the candidate structure under the prespecified constraints. The method includes applying the adjusted parameters to the candidate structure for generating an adjusted candidate structure. The method includes performing iteratively, until a performance threshold associated with the target behavior is reached, steps on the adjusted candidate structure of simulating, evaluating, calculating, optimally adjusting, and applying.
The present description provides methods, assays and reagents useful for sequencing proteins. Sequencing proteins in a broad sense involves observing the plausible identity and order of amino acids, which is useful for sequencing single polypeptide molecules or multiple molecules of a single polypeptide. In one aspect, the methods are useful for sequencing multiple polypeptides. The methods and reagents described herein can be useful for high resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.
A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
Electrochemical devices, and associated materials and methods, are generally described. In some embodiments, an electrochemical device comprises an electroactive material. The electroactive material may comprise an alloy having a solid phase and a liquid phase that co-exist with each other. As a result, such a composite electrode may have, in some cases, the mechanical softness to permit both high energy densities and an improved current density as compared to, for example, a substantially pure metal electrode.
The present disclosure provides copolymers prepared by polymerizing a first monomer comprising at least one C═C and/or at least one C═C; and a second monomer of Formula (B): wherein at least one first monomer and/or at least one second monomer comprises a latent-fluoride moiety (e.g., pentafluorophenyl). Upon contacting the copolymers with a nucleophile (e.g., a thiol) and/or a base, the latent-fluoride moiety may release fluoride ions, which may in turn degrade the copolymers by cleaving the O—Si bonds. The copolymers may be useful for drug delivery, or as degradable (e.g., biodegradable) polymers, adhesives, coatings, or structural materials.
C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) an adjacent exon sequence of a 3′ Group I self-splicing intron-exon, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) an adjacent exon sequence of a 5′ Group I self-splicing intron-exon.
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
47.
ARTICLES AND METHODS FOR GENERATION OF TUNABLE COLORATION AND INTERFERENCE
The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.
Systems, methods, and other embodiments described herein relate to enhancing and complementing a creative process of a user that includes generating and iterating visual content with an emphasis on diverse design ideas. In one embodiment, a method includes generating a plurality of texts that are related and semantically diverse based on one or more prompts using a generative language model and generating a plurality of images based on at least a portion of the plurality of texts using a generative visual model.
C01B 3/08 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents with metals
B01J 19/24 - Stationary reactors without moving elements inside
50.
METHODS AND COMPOSITIONS FOR MODULATING STING SIGNALING AND INNATE IMMUNE RESPONSES
Provided herein are compositions and methods for enhancing the activity of Stimulator of Interferon Genes (STING) with one or more agents for inhibiting the activity of one or more negative regulators of STING, including DNAJC13 and ESCRT.
Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described.
H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells
B60L 50/72 - Constructional details of fuel cells specially adapted for electric vehicles
B60L 58/27 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries for controlling the temperature of batteries by heating
H01M 8/20 - Indirect fuel cells, e.g. fuel cells with redox couple being irreversible
The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
Aspects of inventive concepts are generally directed to a liner, methods of use, methods of design, and related systems. In various embodiments, the liner is configured to serve as an interface between an external surface of a biological body segment of a subject and a prosthetic socket, the biological body segment being amputated below a joint. In various embodiments, a pressure applied by the liner to the biological body segment varies over the length of the liner with a maximum pressure applied at the joint and a lesser pressure applied below the joint.
Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite's location, such as a time stamp or beam pointing information. The femto-satellite can determine its location from the information modulated onto the beam or transmit the time stamp to the mothership satellite for localization.
B64G 3/00 - Observing or tracking cosmonautic vehicles
B64G 1/10 - Artificial satellites; Systems of such satellites; Interplanetary vehicles
G01S 5/16 - Position-fixing by co-ordinating two or more direction or position-line determinations; Position-fixing by co-ordinating two or more distance determinations using electromagnetic waves other than radio waves
G01S 17/74 - Systems using reradiation of electromagnetic waves other than radio waves, e.g. IFF, i.e. identification of friend or foe
55.
METHODS OF TREATING CANCERS HAVING A DEREGULATED NRF2/KEAP1 PATHWAY
The present disclosure relates to a method of treating a subject having cancer that includes selecting a subject having cancer associated with a deregulated NRF2/KEAP1 pathway and administering to the selected subject one or more inhibitors comprising a glutamine transporter inhibitor, a GPD2 inhibitor, or combination(s) thereof.
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 31/475 - Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/655 - Azo (—N=N—), diazo (=N2), azoxy (N—O—N or N(=O)—N), azido (—N3) or diazoamino (—N=N—N) compounds
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
57.
Heterogeneous Integrated UV-IR Ultra-Low Loss Multi-Layer Platform with Electrical Interconnects, Gain, Modulation, Detection, and Nonlinear Optics
National Technology & Engineering Solutions of Sandia, LLC (USA)
Inventor
Blumenthal, Daniel J.
Eichenfield, Matt
Englund, Dirk
Heuck, Mikkel
Abstract
Systems and methods for hybrid integration of ultra-low loss waveguide photonic circuits with various efficient on-chip elements are described. The photonic circuits can integrate various elements including (but not limited to): gain, modulation, detection, and nonlinear optical elements. The integrated photonic chips can be manufactured in a flexible, reconfigurable, 3D heterogeneous platform. The integrated photonic chips can cover wavelength ranges from the visible wavelength to infrared wavelength.
Described herein is a retroreflective underwater backscatter node comprising a receiver that receives an incoming acoustic signal from a first direction; a reflector that reflects back an incoming acoustic signal in a second direction; and a modulator coupled to the reflector to modulate the reflected incoming acoustic signal as a back-scattered signal. In some embodiments, the first direction and second direction are substantially the same such that the retroreflective underwater backscatter node retro-directs an incoming acoustic signal as a back-scattered signal and incoming and back-scattered acoustic signals propagate in the same but substantially opposite directions.
The present disclosure provides methods for profiling spatiotemporal gene expression, including methods for profiling spatiotemporal gene expression in vivo in a subject. The present disclosure also provides methods for profiling the role of post-transcriptional modification in spatiotemporal gene expression, methods for studying the role of spatiotemporal gene expression in the development or progression of a disease or disorder, methods for screening for an agent capable of modulating spatiotemporal gene expression, methods for diagnosing a disease or disorder in a subject, and methods for treating a disease or disorder in a subject. Oligonucleotide probes useful in the methods described herein are also provided by the present disclosure. The present disclosure also provide kits comprising the oligonucleotide probes disclosed herein. Systems for profiling spatiotemporal gene expression are also provided by the present disclosure.
One or more computer processors create a fully convolution network (FCN) comprising a plurality of 1×1 convolutions. The one or more computer processors append linear mapping layer (LM) to created FCN. The one or more computer processors capture a plurality of features utilizing multi-scale dilated convolutional kernels from the linear mapped FCN (LM-FCN). The one or more computer processors apply an average pool layer to the captured plurality of features along a temporal axis of a dilated convolutional kernel within the LM-FCN. The one or more computer processors predict a classification for subsequent time-series data utilizing the pooled plurality of features.
Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycemia, anaphylaxis, and cardiac arrest. A miniaturized (e.g., <3 cm3), lightweight (e.g., <2 g), minimally invasive fully wireless, emergency rescue device for the storage and active burst-release of indefinitely stable particulate forms of peptide and hormone drugs into subcutaneous sites for direct reconstitution in interstitial biofluids is disclosed. The device demonstrates a fast (e.g., <5 minutes) therapeutic effect. The device may deliver a drug across fibrotic tissue, which commonly accumulates following in vivo implantation, thereby accelerating systemic delivery. Fully wireless delivery of dry particulate glucagon in vivo is demonstrated, providing emergency hypoglycemic rescue in diabetic mice. Additionally, triggered delivery of epinephrine is demonstrated in vivo. Additionally, disclosed herein is a platform for the long-term in vivo closed loop delivery of emergency rescue drugs.
A system and method for oxidizing methane can include an environmentally friendly catalyst material that converts methane to an oxidized product at low temperatures and concentrations, for example, under 350° C. at concentrations less than 40% methane, including less than 5% methane.
C07C 45/33 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with molecular oxygen of CHx-moieties
B01J 37/14 - Oxidising with gases containing free oxygen
C07C 29/50 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups with molecular oxygen only
A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.
A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthaldynamometers
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
Enhancing condensation heat transfer performance in applications including power generation, thermal management of high-performance electronics, water purification, distillation, natural gas processing, and air conditioning can be achieved with heat transfer devices. Condensation heat transfer can be enhanced via a hierarchical structure attached on a condenser surface. This novel hierarchical structure is composed of a thin, highly permeable, thermally conductive porous wick and a highly porous, robust, intrinsically hydrophobic membrane bonded or attached on top of the wick.
F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing
F28B 1/00 - Condensers in which the steam or vapour is separated from the cooling medium by walls, e.g. surface condenser
F28D 7/16 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being arranged in parallel spaced relation
65.
Local Drug Delivery Devices and Methods for Treating Cancer
Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/915 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
66.
DRY DOUBLE-SIDED MATERIAL FOR ADHESION OF WET TISSUES AND DEVICES
A method of adhering wet tissues together includes providing a dry adhesive material that contains one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers. The method including the steps of placing the dry adhesive material in contact with one or more wet tissue surfaces; allowing the dry adhesive material to absorb liquid from the one or more wet surfaces to thereby swell the adhesive material; allowing instant crosslinking by intermolecular interactions between the adhesive material and the one or more wet surfaces; and allowing quick covalent crosslinking between the adhesive material and the one or more wet surfaces.
In-network Optical Inference (IOI) provides low-latency machine learning inference by leveraging programmable switches and optical matrix multiplication. IOI uses a transceiver module, called a Neuro Transceiver, with an optical processor to perform linear operations, such as matrix multiplication, in the optical domain. IOI's transceiver modules can be plugged into programmable packet switches, which are programmed to perform non-linear activations in the electronic domain and to respond to inference queries. Processing inference queries at the programmable packet switches inside the network, without sending them to cloud or edge inference servers, significantly reduces end-to-end inference latency experienced by users.
Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for identification of anatomical landmarks from image data. The image analysis provides for guidance for insertion of a cannulation system into an airway of a subject which may be accomplished by a non-expert based upon the guidance provided. The system further enables a single person to perform the cannulation rather than the typical 2 or more people. The guidance may include an indicator or a mechanical guide to guide a user for inserting the cannulation system into a subject to penetrate the airway of interest.
Disclosed are methods of RNA-triggered protein cleavage by the CRISPR Cas7-11-Csx29 complex. A guide RNA specifically hybridizes to a RNA target, and Csx29 cleaves Csx30 when Cas7-11:Csx29 complex binds to the target RNA.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
Provided herein are inorganic nucleic acid supramolecular structures and methods for making them. In certain aspects, the construct includes a structured nucleic acid polymer micelle, which micelle includes a structured nucleic acid template; one or more functional moieties attached to the template; and polymers that interact with nucleic acid present in the template to form the structured nucleic acid polymer micelle; and an inorganic shell surrounding the structured nucleic acid template, in which the one or more functional moieties extend outside the structured nucleic acid polymer micelle and the inorganic shell to maintain functionality.
Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
According to some embodiments, a pressure tolerant camera system includes: an enclosure filled with an incompressible fluid and having a viewport through which light can pass; a digital image sensor provided within the enclosure; and a plurality of mirror lenses provided within the enclosure and arranged to reflect light from the viewport onto the digital image sensor.
G02B 7/182 - Mountings, adjusting means, or light-tight connections, for optical elements for mirrors for mirrors
G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
H04N 23/12 - Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from different wavelengths with one sensor only
H04N 23/57 - Mechanical or electrical details of cameras or camera modules specially adapted for being embedded in other devices
The invention, in part, includes systems and methods for conducting and optimizing continuous evolution of molecules capable of forming multi-body complexes, such as but not limited to evolution of molecules capable of forming three- and four-molecule multi-body complexes.
Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C07K 14/74 - Major histocompatibility complex (MHC)
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A feedback oscillator, with an amplifier whose output is partially fed back to its input, provides a stable reference for standardization and synchronization. The laser is a feedback oscillator whose performance can be limited by quantum fluctuations. The resulting frequency instability, quantified by the Schawlow-Townes formula, sets a limit to laser linewidth. Here, we show that the Schawlow-Townes formula applies to feedback oscillators beyond lasers. This is because it arises from quantum noise added by the amplifier and an out-coupler in the feedback loop. Tracing the origin of quantum noise in an oscillator informs techniques to systematically evade it: squeezing and entanglement can enable sub-Schawlow-Townes linewidth feedback oscillators. We clarify the quantum limits to the stability of feedback oscillators, derive a standard quantum limit (SQL) for feedback oscillators, and disclose quantum strategies for realizing sub-SQL feedback oscillators.
A handheld system radio frequency identification (RFID) system for fine-grained RFID localization of an RFID target. Also disclosed is a mechanism for localizing RFID targets at all orientations through software-controlled polarization of two LP antennas. The system may detect an RFID target using a generated circularly polarized (CP) RF signal and accurately localize the RFID target using a generated linearly polarized (LP) signal. The disclosed systems and techniques discover and localize RFID concurrently and regardless of RFID target orientation.
G01S 13/75 - Systems using reradiation of radio waves, e.g. secondary radar systems; Analogous systems using transponders powered from received waves, e.g. using passive transponders
G01S 13/86 - Combinations of radar systems with non-radar systems, e.g. sonar, direction finder
H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction
78.
SUPERCAPACITORS AND OTHER ELECTRODES AND METHODS FOR MAKING AND USING SAME
H01G 11/28 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features arranged or disposed on a current collector; Layers or phases between electrodes and current collectors, e.g. adhesives
H01G 11/36 - Nanostructures, e.g. nanofibres, nanotubes or fullerenes
H01G 11/56 - Solid electrolytes, e.g. gels; Additives therein
H01G 11/68 - Current collectors characterised by their material
H01G 11/70 - Current collectors characterised by their structure
H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
H01M 4/36 - Selection of substances as active materials, active masses, active liquids
H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.
A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
A61L 24/06 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
A laser microparticle for generating laser light with high omnidirectionality, including: an optical cavity including an active gain material capable of supporting one or more lasing cavity modes: and an optical scattering element which is incorporated into the optical cavity and configured to change a radiation pattern of the one or more lasing cavity modes to increase omnidirectionality of the radiation pattern, the size of the microparticle being less than 10 pm in each dimension.
Dataset distillation compresses large datasets into smaller synthetic coresets that retain performance with the aim of reducing storage and computational burdens of processing an original, entire dataset. The present disclosure provides an improved algorithm that uses a non-deterministic feature approximation of neural network Gaussian process (NNGP) kernels, or other trained kernels, that reduces a kernel matrix computation to O(|S|). When combined with a modified Platt scaling loss, the disclosed algorithm can provide at least a 100-fold speedup over a Kernel-Inducing Points (KIP) algorithm and can run on a single graphics processing unit. The disclosed Random Feature Approximation Distillation (RFAD) algorithm can perform competitively with other dataset condensation algorithms in accuracy over a range of large-scale datasets, both in kernel regression and finite-width network training. The disclosed techniques can be effective on tasks such as model interpretability and data privacy preservation.
Methods and systems are disclosed that enhance the yield and speed of emission and control the spectral and angular emission of light emitted by materials under irradiation by high-energy particles through a process known as scintillation. In each case, a photonic structure (of nano- or micron-scale feature sizes) is integrated with a scintillating material, and the photonic structure enhances the yield or controls the spectrum of the material. Various embodiments of this technology and practical demonstrations are disclosed.
G01T 1/20 - Measuring radiation intensity with scintillation detectors
G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays
G01N 23/2251 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes using incident electron beams, e.g. scanning electron microscopy [SEM]
A mechanical interface connecting a biological body segment, such as a limb, portion of a limb or other body segment, to a wearable device such as a prosthetic, orthotic or exoskeletal device, is fabricated by quantitatively mapping a characterized representation of the body segment to form a digital representation of the mechanical interface shape and mechanical interface impedance. The mechanical interface includes a continuous socket defining a contoured inside surface and a contoured outside surface, and includes a material having an intrinsic impedance that varies through the material, so that the intrinsic impedance varies along the contoured inside surface.
According to one aspect of the disclosure, a converter having a first port and a second port, the converter comprises: a piezoelectric transformer (PT) having a first port and a second port; one or more first switches configured to operate in accordance with a first switching sub-sequence to transfer energy from the first port of the converter to the first port of the PT, the first switching sub-sequence having at least six (6) stages; and one or more second switches configured to operate in accordance with a second switching sub-sequence to transfer energy from the second port of the PT to the second port of the converter.
H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 3/00 - Conversion of dc power input into dc power output
86.
SYSTEM AND METHOD FOR CALIBRATING ELECTROOCULOGRAPHY SIGNALS BASED ON HEAD MOVEMENT
A method for calibrating eye information includes receiving eye state data measured during a calibration period, receiving head state data measured during the calibration period, calibrating the eye state data based on the head state data, and generating an eye angle measurement based on the calibrated eye state data. Calibrating the eye state data may include correlating the eye state data with the head state data during a period when a vestibulo-ocular reflex occurs. In some implementations, the eye state data may include eye movement data and the head state data may include head movement data. The calibrated eye state data is considered to have improved accuracy and therefore may be used as a more reliable basis for determining a variety of health conditions.
A61B 5/398 - Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
87.
METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
Systems and methods for producing electromagnetic devices are provided. The systems and methods allow for an electromagnetic device having both a substrate (e.g., polymer) and conductive material (e.g., metal) to be manufactured without using masks or other outside objects disposed over a surface (e.g., the substrate) onto which the conductive material is deposited. In one exemplary embodiment, the method includes performing additive manufacturing using a polymer to produce a device having a plurality of interconnected walls and a plurality of frequency selective surface elements, and then coating portions of the device with a conductive material. A plurality of shadowing features are formed as part of one or more of the walls to protect the frequency selective surface elements from being coated by the conductive material. Other methods, and a variety of systems that can result from the disclosed methods, are also provided.
B33Y 80/00 - Products made by additive manufacturing
C23C 14/04 - Coating on selected surface areas, e.g. using masks
H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
H05K 3/14 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using spraying techniques to apply the conductive material
89.
SEQUENCE-CONTROLLED POLYMER RANDOM ACCESS MEMORY STORAGE
Methods for controlled segregation of blocks of information encoded in the sequence of a biopolymer, such as nucleic acids and polypeptides, with rapid retrieval based on multiply addressing nanostructured data have been developed. In some embodiments, sequence controlled polymer memory objects include data-encoded biopolymers of any length or form encapsulated by natural or synthetic polymers and including one or more address tags. The sequence address labels are used to associate or select memory objects for sequencing read-out, enabling organization and access of distinct memory objects or subsets of memory objects using Boolean logic. In some embodiments, a memory object is a single-stranded nucleic acid scaffold strand encoding bit stream information that is folded into a nucleic acid nanostructure of arbitrary geometry, including one or more sequence address labels. Methods for controlled degradation of biopolymer-encoded blocks of information in the memory objects are also developed.
B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
G06F 12/06 - Addressing a physical block of locations, e.g. base addressing, module addressing, address space extension, memory dedication
G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change
Providing a trained reinforcement learning (RL) model by formulating a decision process problem for the RL model, defining at least one of a logarithmic loss function for the RL model and defining an initiation point for the RL model according to an optimized spectral norm of the RL model, training the system according to the logarithmic loss function or from the initiation point, and providing the trained RL model.
Provided herein are universal prophylactic compositions for preventing infection with influenza viruses by directing the immune response to highly conserved regions of the virus. Also provided are universal therapeutic compositions for treating influenza infection by targeting the highly conserved regions. Methods for using the prophylactic and therapeutic compositions are also provided.
Systems and methods for rapid flushing of a membrane-based fluid filtration system are disclosed herein. During flushing, a membrane of the system can be decoupled from other portions of the system and brine can be flushed from the membrane separate from the other portions of the system. In some embodiments, the membrane can be connected to a pump to form a flushing loop that is separate from the flushing loops of the main system to flow the flushing fluid therethrough. The flushing fluid through the membrane can be optimized and set based on a flow rate of the membrane to prevent damaging the membrane while minimizing flush time of the membrane relative to the flush time of the system.
The present invention relates to a method of detecting the presence of a bacterial and/or fungal cell in a sample through detecting the presence of nicotinamidase activity or nicotinamidase, wherein the presence of nicotinamidase activity or nicotinamidase indicates the presence of a bacterial and/or fungal cell in the sample. The invention also relates to a method for monitoring bacterial and/or fungal cell contamination in a cell of tissue culture comprising detecting the presence of nicotinamidase activity or nicotinamidase in the cell or tissue culture.
This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and case of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays.
Provided herein are chimeric antigen receptor (CAR) viral libraries and methods of making the same. In some embodiments, the CAR comprises an intracellular domain (ICD) with at least one immune activation signaling domain, one co-stimulatory domain, and one or more inhibitory signaling domain or signaling domain from non-T cell lineages. In some embodiments, the signaling domains of the ICD are joined by distinct linkers of 10 amino acids. In some embodiments, the CARs contain a 18-nucleotide barcode in the 3′ untranslated region. Also provided herein, are CAR cell libraries and methods of making the same.
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
A bearingless split tooth flux-reversal motor (FRM) for use with a pump, such as a centrifugal blood pump. In some embodiments, the motor has a magnet-free rotor and a magnetic configuration wherein the force generation is independent of the rotor angle, allowing for simple radial force generation using stator-fixed currents. The motor torque can be generated using commutated two-phase currents.
H02K 21/40 - Synchronous motors having permanent magnets; Synchronous generators having permanent magnets with rotating flux distributors, and armatures and magnets both stationary with flux distributors rotating around the magnets and within the armatures
A61M 60/109 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
A61M 60/422 - Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
F04D 7/00 - Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts
F04D 13/06 - Units comprising pumps and their driving means the pump being electrically driven
Methods and apparatus for determining a contractile reserve of a heart of a patient are provided. The method includes controlling a heart pump to operate at a first speed, determining based on a motor current signal received from a motor when the heart pump is operating at the first speed, a first value for a cardiac contractility metric, controlling the heart pump to operate at a second speed, determining based, at least in part, on the motor current signal received from the motor when the heart pump is operating at the second speed, a second value for the cardiac contractility metric, determining a contractile reserve metric based, at least in part, on the first value and the second value of the cardiac contractility metric, and outputting an indication of the contractile reserve metric on a user interface associated with the heart pump.
A61M 60/523 - Regulation using real-time patient data using blood flow data, e.g. from blood flow transducers
A61M 60/13 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
A61M 60/17 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
A61M 60/531 - Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
98.
Methods And Apparatus To Generate Macroscopic Fock And Other Sub-Poissonian States Of Radiation
A principle which enables the generation of macroscopic Fock and sub-Poissonian states is disclosed. Generic components of the system include: an electromagnetic structure (possessing one or more electromagnetic resonances), a nonlinear electromagnetic element (such as a nonlinear crystal near or inside the structure), and a source of light. In one embodiment, stimulated gain is used to create large numbers of photons in a cavity, but with very low photon number noise (uncertainty) in the cavity, and thus acts as a Fock laser. This Fock laser is capable of producing these states due to a very sharp intensity-dependent gain (or loss) that selects a particular photon number. The disclosed system and method are robust against both atomic and optical decoherence. Various examples of the new Fock laser design are also described.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
A position sensor with six degrees of freedom (DoF) measurement capability may be used for position sensing of the rotor in a bearingless slice motor to enable active control. The sensor is designed to fit entirely under the rotor and operates by accessing the rotor bottom surface only, enabling packaging of the pump on the top of the rotor. The sensor has two parts; both operate using eddy currents. One of these parts measures the two radial DoF of the rotor. The other part measures the axial, angular rotation and tip/tilt DoF. The sensor utilizes a conductive target fixed to the underside of the rotor. The design and fabrication of the sensor along with the signal processing methods are described.
G01D 5/20 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying inductance, e.g. by a movable armature
G01B 7/30 - Measuring arrangements characterised by the use of electric or magnetic techniques for testing the alignment of axes
patents
