Massachusetts Institute of Technology

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C12N 9/22 - Ribonucleases 32
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA 22
A61K 9/00 - Medicinal preparations characterised by special physical form 21
C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression 18
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides 17
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1.

HANDLING OF FORCES ON TOKAMAK TOROIDAL FIELD COILS

      
Document Number 03237208
Status Pending
Filing Date 2023-01-20
Open to Public Date 2023-07-27
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Labombard, Brian
  • Radovinsky, Alexey
  • Brunner, Daniel
  • Lammi, Christopher J.
  • Mumgaard, Robert
  • Ames, Nicoli
  • Kan, Frank
  • Riccardo, Valeria
  • Bolz, Edwin

Abstract

Some aspects relate to a toroidal field (TF) coil for a tokamak. The TF coil includes a first inner leg having teeth on a side of the first inner leg. The corresponds to an interface between the TF coil and a second TF coil. The teeth extend along a direction having a component in a radial direction of the tokamak. The teeth are configured to mechanically engage with second teeth of a second inner leg of the second TF coil.

IPC Classes  ?

  • G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
  • G21B 1/11 - Thermonuclear fusion reactors - Details
  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

2.

DYNAMICALLY RECONFIGURABLE ARCHITECTURES FOR QUANTUM INFORMATION AND SIMULATION

      
Document Number 03223084
Status Pending
Filing Date 2022-08-02
Open to Public Date 2023-07-13
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Bluvstein, Dolev
  • Levine, Harry Jay
  • Semeghini, Giulia
  • Wang, Tout
  • Ebadi, Sepehr
  • Keesling Contreras, Alexander
  • Lukin, Mikhail D.
  • Greiner, Markus
  • Vuletic, Vladan

Abstract

Dynamically reconfigurable architectures for quantum information and simulation are provided. A plurality of neutral atoms is provided. Each neutral atom is disposed in a corresponding optical trap. Each of the plurality of neutral atoms is prepared in a mF = 0 clock state. A pair of neutral atoms of the plurality of neutral atoms is entangled by directing a laser pulse thereto. The laser pulse is configured to transition the pair of neutral atoms through a Rydberg state. The optical trap corresponding to at least one neutral atom of the pair is adiabatically moved, thereby moving one atom of the pair relative to the other atom of the pair without destroying entanglement of the pair.

IPC Classes  ?

  • G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
  • G06N 10/70 - Quantum error correction, detection or prevention, e.g. surface codes or magic state distillation

3.

SEQUENTIALLY STACKED MULTI-STAGE DESALINATION SYSTEM AND METHOD

      
Document Number 03239916
Status Pending
Filing Date 2022-10-27
Open to Public Date 2023-07-06
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Han, Jongyoon
  • Yoon, Junghyo

Abstract

A sequentially stacked multi-stage desalination system includes a single pair of electrodes, including an anode and a cathode; at least one ion concentration polarization device; and at least one electrodialysis device coupled with the ion concentration polarization device and configured to receive liquid flow from the ion concentration polarization device. Each ion concentration device and electrodialysis device is positioned between the anode and the cathode.

IPC Classes  ?

  • B01D 61/42 - Electrodialysis; Electro-osmosis
  • C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis

4.

CONTINUOUS EMISSIONS MONITOR FOR DIRECTED-ENERGY BOREHOLE DRILLING

      
Document Number 03239978
Status Pending
Filing Date 2022-10-18
Open to Public Date 2023-06-29
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor Woskov, Paul P.

Abstract

Apparatus and methods for monitoring emissions from a borehole to determine the composition of earthen material removed from the borehole are described. Monitoring can be done in real time as the borehole is being deepened with a millimeter-wave drilling beam. The present technology can monitor in real-time the elemental composition of the earthen materials (e.g., rock, minerals, crystals, metals, etc.) in a borehole created by a directed-energy beam that melts and vaporizes the earthen material materials in its path. Using a continuous emissions monitor (CEM) in combination with directed-energy excavation of a borehole enables rapid surveying of the subsurface for precious and commercial metals.

IPC Classes  ?

  • E21B 7/15 - Drilling by use of heat, e.g. flame drilling of electrically generated heat
  • G01N 21/67 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence using electric arcs or discharges

5.

RATE OF PENETRATION/DEPTH MONITOR FOR A BOREHOLE FORMED WITH MILLIMETER-WAVE BEAM

      
Document Number 03240438
Status Pending
Filing Date 2022-10-18
Open to Public Date 2023-06-29
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor Woskov, Paul P.

Abstract

Apparatus and methods are described for drilling deep boreholes with millimeter-wave radiation in earthen materials to access deep resources such as geothermal heat. Borehole depth and temperature at the bottom of the borehole can be monitored with probe signals and/or radiative emission from the bottom of the borehole.

IPC Classes  ?

  • E21B 7/15 - Drilling by use of heat, e.g. flame drilling of electrically generated heat
  • E21B 47/135 - Means for transmitting measuring-signals or control signals from the well to the surface, or from the surface to the well, e.g. for logging while drilling by electromagnetic energy, e.g. of radio frequency range using light waves, e.g. infrared or ultraviolet waves
  • E21B 47/04 - Measuring depth or liquid level

6.

COLD-TEMPERATURE ISOTHERMAL AMPLIFICATION OF POLYNUCLEOTIDES

      
Document Number 03242249
Status Pending
Filing Date 2022-12-07
Open to Public Date 2023-06-15
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Angenent-Mari, Nicolaas
  • Collins, James J.

Abstract

In some aspects, the present disclosure provides methods and compositions for isothermal low temperature amplification of target polynucleotides, and detection thereof.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

7.

PREDICTION, BIOSYNTHESIS, AND INTEGRATION AS BIOSENSORS OF MOLECULES WITH UNIQUE LIGHT ABSORBANCE SIGNATURES AND THEIR SUBSEQUENT IN-FIELD REMOTE DETECTION USING MULTI OR HYPER-SPECTRAL CAMERAS

      
Document Number 03242287
Status Pending
Filing Date 2022-10-07
Open to Public Date 2023-06-15
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Voigt, Christopher A.
  • Chemla, Yonatan
  • Levin, Itai

Abstract

Disclosed herein are biosensors that are hyperspectral reporters. The biosensors are useful for detecting information about the environment and environmental conditions in a number of fields including agriculture. Also provided are methods of making and using the biosensors.

IPC Classes  ?

  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

8.

SINGLE-CELL DENSITY AS A BIOMARKER FOR DRUG SENSITIVITY

      
Document Number 03240844
Status Pending
Filing Date 2022-12-01
Open to Public Date 2023-06-08
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • DANA-FARBER CANCER INSTITUTE, INC. (USA)
Inventor
  • Manalis, Scott R.
  • Ligon, Keith
  • Wu, Weida
  • Miettinen, Teemu Petteri
  • Ishamuddin, Sarah
  • Chow, Kin-Hoe

Abstract

Systems and methods for determining a density of a particle suspected of having been exposed to a therapeutic agent are generally described.

IPC Classes  ?

  • G01N 9/36 - Analysing materials by measuring the density or specific gravity, e.g. determining quantity of moisture
  • G01N 15/14 - Electro-optical investigation
  • G01N 33/483 - Physical analysis of biological material

9.

HIGH-THROUGHPUT AND HIGH-PRECISION MEASUREMENT OF SINGLE-CELL DENSITY

      
Document Number 03240190
Status Pending
Filing Date 2022-12-01
Open to Public Date 2023-06-08
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Manalis, Scott R.
  • Wu, Weida
  • Miettinen, Teemu Petteri

Abstract

Systems and methods for determining a property (e.g., density) of a particle (e.g., a cell) are generally described.

IPC Classes  ?

  • G01N 9/36 - Analysing materials by measuring the density or specific gravity, e.g. determining quantity of moisture

10.

MULTIFUNCTIONAL MICROELECTRONICS FIBERS AS IMPLANTABLE BIOELECTRONIC INTERFACES

      
Document Number 03237747
Status Pending
Filing Date 2022-11-16
Open to Public Date 2023-05-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Anikeeva, Polina Olegovna
  • Sahasrabudhe, Atharva
  • Rupprecht, Laura
  • Khudiyev, Tural
  • Bohorquez, Diego

Abstract

Multifunctional microelectronics fiber probes can be chronically implanted in tissue of awake- behaving animals for understanding brain-viscera communication. These fiber probes can be made using thermal drawing to make hundreds of meters of flexible fiber that incorporates features such as light sources, electrodes, thermal sensors, and microfluidic channels in a multilayered configuration. The fiber mechanics can be tuned for two distinct device layouts: (1) higher- modulus, flexible brain fibers for implantation into deep-brain; and (2) soft, compliant gut fibers for implantation into the small intestine. Brain fibers can modulate the deep-brain mesolimbic reward pathway. Gut fibers can perform peripheral optogenetic stimulation of vagal afferents from the intestine to stimulate brain reward neurons. Brain and gut fibers can be connected to a control module, for example, with a coiled, stretchable interconnect that is more flexible and stretches more than even soft gut fibers, in dual-organ (gut-brain) implantation.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

11.

MODULAR HIGH CAPACITY CURRENT LEAD

      
Document Number 03231792
Status Pending
Filing Date 2022-11-10
Open to Public Date 2023-05-19
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Fry, Vincent
  • Zhukovsky, Alexander
  • Michael, Philip
  • Ihloff, Ernest
  • Wolf, Michael
  • Beck, William

Abstract

A high capacity current lead (10) comprises components that are electrically coupled using indium joints. The current lead includes a heat exchanger having a portion at room temperature (100) and a portion (200) within a vacuum cryostat. The room-temperature portion is temperature controlled against both overheating and overcooling. The cryogenic portion (200) of the heat exchanger is electrically coupled to a coolant boiling chamber (300) using indium joints. The boiling chamber (300) has a lid and a base that may be electrically coupled using indium joints, or they may be brazed. The boiling chamber (300) is surrounded by a vacuum lid that may be electrically coupled to the base using indium joints, or brazed. The base is electrically coupled to a superconductor module (400) having high-temperature superconductor (HTS) tapes for conveying current to a device, such as a superconducting electromagnet.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01R 4/68 - Connections to or between superconductive conductors
  • H02G 15/34 - Cable fittings for cryogenic cables

12.

PROCESSES, SYSTEMS AND DEVICES FOR METAL-FILLING OF OPEN HTS CHANNELS

      
Document Number 03234268
Status Pending
Filing Date 2022-11-15
Open to Public Date 2023-05-19
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Hubbard, Amanda
  • Labombard, Brian
  • Murray, Richard
  • Irby, James
  • Vieira, Rui
  • Beck, William
  • Toland, Thomas
  • Fry, Vincent
  • Schweiger, Shane
  • Watterson, Amelia
  • Chamberlain, Sarah
  • Estrada, Jose
  • Mouratidis, Theodore
  • Stevens, Kenneth

Abstract

Described are concepts, systems, structures and techniques for metal filling an open channel (12) in a baseplate (19). In embodiments, metal filling of an open baseplate channel is achieved using vacuum pressure impregnation (VPI). In embodiments, a compression plate (14a) is disposed over an open baseplate channel (12) to be filled with a molten metal. In embodiments, gaskets (97) are disposed between the compression plate (14a) and a surface of the baseplate (10) proximate the baseplate channel (12). In embodiments, a channel cap (26) is disposed over the open channel. In embodiments, the channel cap (26) has a solder flow channel (29, 32) provided in a surface thereof. In the embodiments, the solder flow channel (29, 32) has a meandering shape. In embodiments, a solder flow channel (29, 32') is provided in the compression plate (14a) and/or the baseplate (10). The concepts, systems, structures and techniques described herein are suitable for use in the fabrication of a no-insulation, no-twist (NINT) high temperature superconducting (HTS) magnet.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils

13.

DISPERSIVE OPTICS FOR SCALABLE RAMAN DRIVING OF HYPERFINE QUBITS

      
Document Number 03223061
Status Pending
Filing Date 2022-07-15
Open to Public Date 2023-05-11
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Levine, Harry Jay
  • Bluvstein, Dolev
  • Keesling Contreras, Alexander
  • Semeghini, Giulia
  • Ebadi, Sepehr
  • Wang, Tout
  • Omran, Ahmed
  • Lukin, Mikhail D.
  • Greiner, Markus
  • Vuletic, Vladan

Abstract

A device for modulating an amplitude of a light beam, comprising a coherent light source configured to generate a phase -modulated beam having a plurality of frequency components; and a dispersive optical element. The dispersive optical element has a group delay dispersion and is configured to receive the phase-modulated beam, to introduce an optical phase shift to each of the plurality of the frequency components, so that the values of the optical phase shift vary non-linearly with frequency according to the group delay dispersion, and to recombine the plurality of frequency components, thereby generating an amplitude -modulated beam.

IPC Classes  ?

  • G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
  • H04B 10/2519 - Arrangements specific to fibre transmission for the reduction or elimination of distortion or dispersion due to chromatic dispersion using Bragg gratings
  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
  • G02F 1/11 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on acousto-optical elements, e.g. using variable diffraction by sound or like mechanical waves
  • G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
  • G02F 1/33 - Acousto-optical deflection devices

14.

ENGINEERED CARDIAC MUSCLE COMPOSITIONS

      
Document Number 03236534
Status Pending
Filing Date 2022-10-05
Open to Public Date 2023-04-13
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sabeti, Pardis
  • Tabebordbar, Mohammadsharif
  • Ye, Simon

Abstract

Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of one or more n-mer inserts, that can include one or more RGD motifs, and/or one or more P-motifs. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.

IPC Classes  ?

  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • A61P 9/02 - Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

15.

SINGLE MOLECULE ASSAYS FOR ULTRASENSITIVE DETECTION OF ANALYTES

      
Document Number 03231674
Status Pending
Filing Date 2022-10-05
Open to Public Date 2023-04-13
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Walt, David, R.
  • Wu, Connie
  • Novak, Richard
  • Dougan, Tyler
  • Ahmad, Rushdy

Abstract

The invention provides ultrasensitive methods for detection and quantification of target analytes in samples. The methods can be multiplexed to allow simultaneous detection and quantification of multiple target analytes. The methods can achieve an attomolar limit of detection. The invention also provides related compositions and kits.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6869 - Methods for sequencing
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/532 - Production of labelled immunochemicals
  • G01N 33/533 - Production of labelled immunochemicals with fluorescent label

16.

COMPOSITIONS AND METHODS FOR ENHANCING WNT SIGNALING FOR TREATING CANCER

      
Document Number 03233974
Status Pending
Filing Date 2022-10-07
Open to Public Date 2023-04-13
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE GENERAL HOSPITAL CORPORATION (USA)
Inventor
  • Eng, George
  • Yilmaz, Omer
  • Braverman, Jonathan

Abstract

Methods and compositions for enhancing Wnt signaling pathway activities in a tissue of a subject have been developed for the treatment of cancer, in particular cancers with one or more mutations in the APC (adenomatous polyposis coli) gene. Preferably, the amount of the compositions for enhancing Wnt signaling does not reduce or inhibit proliferation or viability of normal healthy cells in the subject. In some embodiments, pharmaceutical compositions including an effective amount of one or more GSK-3 inhibitors are administered to reduce cancer cell proliferation or viability in a subject. A preferred GSK-3 inhibitor is LY2090314 encapsulated within, or associated with nanoparticles. Dosage forms of LY2090314 encapsulated within, or associated with nanoparticles for administration are also described.

IPC Classes  ?

  • A61K 31/513 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
  • A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
  • A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
  • A61P 35/00 - Antineoplastic agents

17.

OPTIMIZED TREE ENSEMBLE BASED DEMAND MODEL

      
Document Number 03229035
Status Pending
Filing Date 2022-07-18
Open to Public Date 2023-04-06
Owner
  • ORACLE INTERNATIONAL CORPORATION (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Thayaparan, Leann
  • Panchamgam, Kiran V.
  • Borjian, Setareh
  • Perakis, Georgia

Abstract

Embodiments generate an optimized demand model for a retail item. Embodiments train a tree ensemble machine learning model comprising a plurality of trees, the training comprising storing upper bounds for each of the trees, the trees comprising levels and branches that correspond to the demand features that influence demand for the item. Embodiments generate an objective function for the demand model. At a top split of each tree, embodiments determine optimal child nodes using the stored upper bounds and calculate a new feasible region for each tree. Using bounds on the new feasible region, embodiments move down each tree to a next level of splits and generate the optimized demand model when a leaf node of every tree has been reached.

IPC Classes  ?

  • G06Q 30/02 - Marketing; Price estimation or determination; Fundraising
  • G06N 20/20 - Ensemble learning

18.

ACTIVE PIEZOELECTRIC SHEET WITH PIEZOELECTRIC MICROSTRUCTURES

      
Document Number 03226612
Status Pending
Filing Date 2022-07-01
Open to Public Date 2023-02-23
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Han, Jinchi
  • Lang, Jeffrey H.
  • Bulovic, Vladimir

Abstract

An active acoustic system includes a thin-film sheet having an array of piezoelectric microstructures embossed in the film. Each piezoelectric microstructure may act as a speaker and/or a microphone. A control circuit is configured to individually address the piezoelectric microstructures to provide a separate voltage signal to, or receive a separate voltage signal from, each piezoelectric microstructure.

IPC Classes  ?

  • B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction

19.

IN SITU EPITRANSCRIPTOMIC PROFILING

      
Document Number 03228406
Status Pending
Filing Date 2022-08-10
Open to Public Date 2023-02-16
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Wang, Xiao
  • Zeng, Hu
  • Ren, Jingyi
  • Tian, Jiakun
  • Guo, Jianting

Abstract

The present disclosure provides methods, compositions, and systems for profiling epitranscriptomic RNA modifications in a cell. The present disclosure also provides methods for profiling interactions between one or more RNAs of interest in a cell and an RNA-binding protein (e.g., a protein that introduces an epitranscriptomic modification on an RNA of interest). Also provided by the present disclosure are methods for diagnosing a disease or disorder in a subject based on a profile of epitranscriptomic RNA modifications or a profile of interactions between an RNA binding protein and RNAs in a cell, including cells within an intact tissue. Methods of screening for or testing a candidate agent capable of modulating epitranscriptomic modification of one or more RNAs or interactions between one or more RNAs and an RNA-binding protein are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder in a subject in need thereof. Pairs of probes and sets of probes comprising oligonucleotide portions, which may be useful for performing the methods described herein, are also described by the present disclosure. Additionally, the present disclosure provides kits comprising any of the probes described herein.

IPC Classes  ?

  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

20.

ARTICLES, SYSTEMS, AND METHODS FOR THE INJECTION OF VISCOUS FLUIDS

      
Document Number 03228175
Status Pending
Filing Date 2022-04-11
Open to Public Date 2023-02-09
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Varanasi, Kripa K.
  • Jayaprakash, Vishnu
  • Rufer, Simon B.

Abstract

Disclosed herein are articles, systems, and methods for the injection of viscous fluids. For example, inventive articles, systems, and methods for injecting viscous fluids, such as concentrated drug formulations, via droplet lubrication are described.

IPC Classes  ?

  • A61M 5/19 - Syringes having more than one chamber
  • A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically

21.

FIBER OPTIC QUENCH DETECTION

      
Document Number 03226661
Status Pending
Filing Date 2022-08-05
Open to Public Date 2023-02-09
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Salazar, Erica
  • Hartwig, Zachary

Abstract

A high temperature superconductor (HTS) cable includes at least one HTS tape stack extending along a length of the HTS cable; and at least one optical fiber extending along the HTS cable. The at least one optical fiber has a plurality of gratings spaced apart from one another along the length of the HTS cable to detect a quench of the at least one HTS tape stack.

IPC Classes  ?

  • G01K 11/3206 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering

22.

DUAL-BARREL INJECTOR AND ASSOCIATED SYSTEMS AND METHODS

      
Document Number 03228133
Status Pending
Filing Date 2022-04-11
Open to Public Date 2023-02-09
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Varanasi, Kripa K.
  • Jayaprakash, Vishnu

Abstract

Articles such as dual-barrel injectors are generally described. Associated systems and methods are also described. In some embodiments, the articles are useful for injecting viscous fluids, such as concentrated drug formulations. In certain embodiments, the article comprises a first conduit (e.g., for transporting a viscous fluid) and a second conduit (e.g., for transporting a lubricating fluid). In some embodiments, the fluid from the second conduit (e.g., a lubricating fluid) lubricates the flow of the fluid from the first conduit (e.g., a viscous drug) by surrounding the fluid from the first conduit, and the lower viscosity of the fluid from the second conduit allows the fluid from the first conduit to flow more easily through the system.

IPC Classes  ?

  • A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M 5/19 - Syringes having more than one chamber
  • A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing

23.

ENGINEERED MUSCLE TARGETING COMPOSITIONS

      
Document Number 03230479
Status Pending
Filing Date 2022-08-05
Open to Public Date 2023-02-09
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sabeti, Pardis
  • Tabebordbar, Mohammadsharif
  • Ye, Simon

Abstract

Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.

IPC Classes  ?

  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

24.

LOCALIZING, WAKING-UP, AND ESTIMATING DIRECTION OF FEMTO-SATELLITES

      
Document Number 03214943
Status Pending
Filing Date 2022-05-03
Open to Public Date 2023-01-12
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Cahoy, Kerri
  • Haughwout, Christian
  • Serra, Paul
  • Han, Ruonan
  • Chandrakasan, Anantha

Abstract

Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite' s location, such as a time stamp or beam pointing information. The femto-satellite can determine its location from the information modulated onto the beam or transmit the time stamp to the mothership satellite for localization.

IPC Classes  ?

  • B64G 1/10 - Artificial satellites; Systems of such satellites; Interplanetary vehicles
  • G01S 19/00 - Satellite radio beacon positioning systems; Determining position, velocity or attitude using signals transmitted by such systems
  • G01S 5/00 - Position-fixing by co-ordinating two or more direction or position-line determinations; Position-fixing by co-ordinating two or more distance determinations
  • H04B 7/185 - Space-based or airborne stations
  • H04W 84/06 - Airborne or Satellite Networks

25.

SINGLE-CELL PROFILING OF RNA TRANSLATION STATUS

      
Document Number 03223946
Status Pending
Filing Date 2022-06-28
Open to Public Date 2023-01-05
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Wang, Xiao
  • Zeng, Hu
  • Ren, Jingyi

Abstract

The present disclosure provides methods and systems for profiling RNAs being translated in a cell. Also provided by the present disclosure are methods for diagnosing a disease or disorder in a subject based on a profile of the RNAs being translated in a cell, including cells within an intact tissue. Methods of screening for or testing a candidate agent capable of modulating translation of one or more RNAs are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder in a subject in need thereof. Pairs of probes and sets of probes comprising oligonucleotide portions, which may be useful for performing the methods described herein, are also described by the present disclosure. Additionally, the present disclosure provides kits comprising any of the probes described herein.

IPC Classes  ?

26.

SYNTHESIS OF COVALENT PROTEIN DIMERS THAT CAN INHIBIT MYC-DRIVEN TRANSCRIPTION

      
Document Number 03223698
Status Pending
Filing Date 2022-06-17
Open to Public Date 2022-12-29
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (USA)
Inventor
  • Loas, Andrei
  • Pentelute, Bradley L.
  • Pomplun, Sebastian
  • Jbara, Muhammad
  • Schissel, Carly Katherine
  • Rodriquez, Jacob Joshua Lee
  • Buchwald, Stephen Leffler
  • Boija, Ann
  • Klein, Isaac
  • Hawken, Susana Wilson
  • Li, Charles Han

Abstract

The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.

IPC Classes  ?

  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals

27.

DEAMINASE-BASED RNA SENSORS

      
Document Number 03222560
Status Pending
Filing Date 2022-06-14
Open to Public Date 2022-12-22
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
Inventor
  • Jiang, Kaiyi
  • Krajeski, Rohan Neil
  • Abudayyeh, Omar Osama
  • Gootenberg, Jonathan S.
  • Zhang, Yifan
  • Chen, Fei
  • Chen, Xi
  • Koob, Jeremy G.

Abstract

RNA editing tools for use in systems designed to measure RNA in vivo and manipulate specific cell types are disclosed herein. An RNA sensor system comprising a) a single-stranded RNA (ssRNA) sensor comprising a stop codon and a payload; optionally wherein the ssRNA sensor further comprises a normalizing gene; and b) an adenosine deaminase acting on RNA (ADAR) deaminase; wherein the sensor is capable of binding to a ssRNA target to form a double-stranded RNA (dsRNA) duplex that becomes a substrate for the ADAR deaminase; wherein the substrate comprises a mispairing within the stop codon; and wherein the mispairing is editable by the ADAR deaminase, which editing can effectively remove the stop codon so as to enable translation and expression of the payload. A method of quantifying ribonucleic acid (RNA) levels using the RNA sensor system is also disclosed.

IPC Classes  ?

  • C12Q 1/6825 - Nucleic acid detection involving sensors

28.

SYSTEMS, METHODS, AND COMPOSITIONS COMPRISING MINIATURE CRISPR NUCLEASES FOR GENE EDITING AND PROGRAMMABLE GENE ACTIVATION AND INHIBITION

      
Document Number 03223009
Status Pending
Filing Date 2022-06-16
Open to Public Date 2022-12-22
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Jiang, Kaiyi
  • Villiger, Lukas
  • Abudayyeh, Omar Osama
  • Gootenberg, Jonathan S.

Abstract

This disclosure provides systems, methods, and compositions comprising miniature CRISPR. nucleases for gene editing and programmable gene activation and inhibition. The miniature CRISPR nuclease is a target specific nuclease having a compact structure with a small number of amino acids. The target specific nuclease targets DNA and is directed to a target nucleic acid sequence from the DNA by a guide RNA. In some embodiments, the target specific nuclease exhibits DNA cleavage activity and is directed by a gRNA to a target nucleic acid sequence from a DNA. In some embodiments, the target specific nuclease does not exhibit DNA cleavage activity and is directed by a gRNA to a target nucleic acid sequence from a DNA.

IPC Classes  ?

  • C12N 9/22 - Ribonucleases
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

29.

SYSTEMS AND METHODS FOR SUGAR-REDUCTION AND/OR FIBER PRODUCTION FOR FOOD AND OTHER APPLICATIONS

      
Document Number 03222942
Status Pending
Filing Date 2022-06-08
Open to Public Date 2022-12-15
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Ingber, Donald E.
  • Gnyawali, Vaskar
  • Harrier, Danielle
  • Liu, Yan
  • Zhao, Evan Minghao
  • Weitz, David A.
  • Collins, James J.
  • Sesay, Adama Marie
  • Haney, Bobby Tyrell

Abstract

The present disclosure generally relates to sugar reduction in foods and, in some aspects, to enzyme-polymer conjugated particles for food and other applications. Certain aspects of the disclosure are directed to compositions for reducing sugar content and/or producing dietary fiber within food products during or after consumption (e.g., in a subject's gastrointestinal (Gl) tract), while maintaining the sweetness and flavor of the sugar in food products upon consumption (e.g., in a subject's mouth). For example, in one set of embodiments, a composition may comprise a particle comprising an enzyme capable of converting a sugar into a relatively non-digestible form (e.g., a polymer), optionally an inhibitor that reversibly inhibits the enzyme from converting the sugar, and optionally an additive capable of associating with the inhibitor. The composition may be used for in situ conversion of sugars upon exposure to an environment condition (e.g., pH and/or temperature) in the Gl tract.

IPC Classes  ?

  • C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
  • A23L 33/125 - Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing starch hydrolysates
  • A23L 29/30 - Foods or foodstuffs containing additives; Preparation or treatment thereof containing starch hydrolysates, e.g. dextrin
  • A61K 31/05 - Phenols

30.

CO-MAPPING TRANSCRIPTIONAL STATES AND PROTEIN HISTOLOGY

      
Document Number 03219339
Status Pending
Filing Date 2022-05-27
Open to Public Date 2022-12-01
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Wang, Xiao
  • Zeng, Hu
  • Ren, Jingyi

Abstract

The present disclosure provides methods and systems for mapping gene and protein expression in a cell (i.e., mapping gene and protein expression within the same cell simultaneously). The present disclosure also provides methods for diagnosing a disease or disorder (e.g., a neurological disorder such as Alzheimer's disease) in a subject. Methods of screening for a candidate agent capable of modulating gene and/or protein expression are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder, such as Alzheimer's disease, in a subject in need thereof. A plurality of oligonucleotide probes, which may be useful for performing the methods described herein, are also described by the present disclosure, as well as kits comprising any of the oligonucleotide probes described herein. Additionally, the present disclosure provides methods, apparatuses, and non-transitory computer-readable storage media for identifying spatial variations of cell types in at least one image.

IPC Classes  ?

31.

MODIFIED MRNA, MODIFIED NON-CODING RNA, AND USES THEREOF

      
Document Number 03218778
Status Pending
Filing Date 2022-05-11
Open to Public Date 2022-11-17
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Wang, Xiao
  • Shi, Hailing
  • Aditham, Abhishek

Abstract

Disclosed herein are modified niRNAs and modified non-coding RNAs with poly(A) tails containing modified nucleotides and/or secondary structures, which may be made by ligation of a tailing nucleic acid onto the 3' terminal end of an RNA. Also provided are compositions comprising one or more modified mRNAs or modified non-coding RNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.

IPC Classes  ?

  • A61K 31/00 - Medicinal preparations containing organic active ingredients
  • A61P 37/04 - Immunostimulants
  • C12N 15/67 - General methods for enhancing the expression

32.

SPATIOTEMPORALLY RESOLVED TRANSCRIPTOMICS AT SUBCELLULAR RESOLUTION

      
Document Number 03218089
Status Pending
Filing Date 2022-05-06
Open to Public Date 2022-11-10
Owner
  • THE BROAD INSTITUTE INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Wang, Xiao
  • Ren, Jingyi
  • Zeng, Hu

Abstract

The present disclosure provides methods for profiling spatiotemporal gene expression, including methods for profiling spatiotemporal gene expression in vivo in a subject. The present disclosure also provides methods for profiling the role of post-transcriptional modification in spatiotemporal gene expression, methods for studying the role of spatiotemporal gene expression in the development or progression of a disease or disorder, methods for screening for an agent capable of modulating spatiotemporal gene expression, methods for diagnosing a disease or disorder in a subject, and methods for treating a disease or disorder in a subject. Oligonucleotide probes useful in the methods described herein are also provided by the present disclosure. The present disclosure also provides kits comprising the oligonucleotide probes disclosed herein. Systems for profiling spatiotemporal gene expression are also provided by the present disclosure.

IPC Classes  ?

33.

ALUMINUM-CHALCOGEN BATTERIES WITH ALKALI HALIDE MOLTEN SALT ELECTROLYTES

      
Document Number 03216099
Status Pending
Filing Date 2022-03-11
Open to Public Date 2022-10-27
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sadoway, Donald R.
  • Pang, Quanquan
  • Meng, Jiashen
  • Zhao, Ji

Abstract

A rechargeable, self-heating aluminum-chalcogen battery is provided, with an aluminum or aluminum alloy negative electrode, a positive electrode of elemental chalcogen, and a mixture of chloride salts providing a molten salt electrolyte. The predominant chloride salt in the electrolyte is AlCh. Additional chloride salts are chosen from alkali metal chlorides. The cell operates at a modestly elevated temperatures, ranging from 90 °C to 250 °C.

IPC Classes  ?

  • H01M 4/46 - Alloys based on magnesium or aluminium
  • H01M 10/653 - Means for temperature control structurally associated with the cells characterised by electrically insulating or thermally conductive materials
  • H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
  • H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells

34.

VIRAL TARGETING OF HEMATOPOIETIC STEM CELLS

      
Document Number 03216882
Status Pending
Filing Date 2022-04-16
Open to Public Date 2022-10-20
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Birnbaum, Michael
  • Dobson, Connor
  • Gaglione, Stephanie
  • Roybal, Kole
  • Burnett, Cassandra

Abstract

Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery to a hematopoietic stem cell (HSC), wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non- viral membrane -bound protein comprising a membrane-bound domain and an extracellular targeting domain.

IPC Classes  ?

  • C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/86 - Viral vectors

35.

ULTRAFAST DETECTOR OF RYDBERG ATOMS

      
Document Number 03204993
Status Pending
Filing Date 2022-02-11
Open to Public Date 2022-08-18
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Xu, Wenchao
  • Vuletic, Vladan
  • Cantu, Sergio H.
  • Kluesener, Valentin
  • Venkatramani, Aditya V.
  • Lukin, Mikhail D.
  • Sumarac, Tamara

Abstract

A device, comprising at least one monochromatic light source configured to generate a first optical trap; an ensemble of particles disposed in the first optical trap, each particle of the ensemble of particles being excitable to a first Rydberg state and a second Rydberg state, the second Rydberg state having a blockade radius, each particle of the ensemble of particles being within the blockade radius of each other and within the blockade radius of an atomic qubit, the atomic qubit being a particle that is excitable to the second Rydberg state, the ensemble of particles having a first transmissivity at a first wavelength when neither any particle of the ensemble of particles nor the atomic qubit is in the second Rydberg state, the ensemble of particles having a second transmissivity at the first wavelength when the atomic qubit is in the second Rydberg state, the second transmissivity being lower than the first transmissivity; and a second monochromatic light source configured to drive each particle of the ensemble of particles into the first Rydberg state; a probe light source configured to direct a probe beam having the first wavelength to the ensemble of particles; and a photosensor configured to determine the state of the atomic qubit.

IPC Classes  ?

  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
  • G02F 1/33 - Acousto-optical deflection devices
  • G02F 2/02 - Frequency-changing of light, e.g. by quantum counters

36.

SHAPE MEMORY ADHESIVE MATERIALS FOR DIABETIC WOUND HEALING

      
Document Number 03208233
Status Pending
Filing Date 2022-02-09
Open to Public Date 2022-08-18
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • BETH ISRAEL DEACONESS MEDICAL CENTER (USA)
Inventor
  • Zhao, Xuanhe
  • Yuk, Hyunwoo
  • Roh, Heejung
  • Veves, Aristidis
  • Theocharidis, Georgios

Abstract

A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre- stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.

IPC Classes  ?

  • A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

37.

HYDRATION-BASED SHAPE MEMORY ADHESIVE MATERIALS AND METHODS OF MAKING

      
Document Number 03208237
Status Pending
Filing Date 2022-02-10
Open to Public Date 2022-08-18
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhao, Xuanhe
  • Yuk, Hyunwoo
  • Roh, Heejung

Abstract

A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.

IPC Classes  ?

  • A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
  • A61L 15/42 - Use of materials characterised by their function or physical properties
  • A61L 15/58 - Adhesives
  • A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
  • A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
  • A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
  • C08K 5/20 - Carboxylic acid amides

38.

JOINT SCHEMES FOR STACKED PLATE, NON-INSULATED SUPERCONDUCTING MAGNETS

      
Document Number 03203940
Status Pending
Filing Date 2022-01-27
Open to Public Date 2022-08-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Fry, Vincent
  • Vieira, Rui
  • Labombard, Brian

Abstract

Schemes are described for joint geometry and placement in superconducting magnets. According to some aspects, a joint may be implemented in a modular component of a superconducting magnet, such as a plate that includes a spiral superconducting path, with the joints providing electrically conductive connections between the superconducting paths of adjacent plates. A joint may be installed and coupled to the component (e.g., plate) after its fabrication, thereby providing freedom in design of both the joint and the component. In at least some cases, the joints may be arranged to be flush with a surface of the component after installation into the component so that neighboring instances of the components may be stacked flush with one another, thereby putting joints from the neighboring components into intimate contact with one another.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

39.

REPROGRAMMABLE TNPB POLYPEPTIDES AND USE THEREOF

      
Document Number 03204810
Status Pending
Filing Date 2022-01-25
Open to Public Date 2022-07-28
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhang, Feng
  • Altae-Tran, Han
  • Kannan, Soumya
  • Nety, Suchita

Abstract

Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.

IPC Classes  ?

  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

40.

METHODS AND COMPOSITIONS FOR INCREASING THE CONCENTRATION OF CELL FREE DNA

      
Document Number 03209121
Status Pending
Filing Date 2022-01-25
Open to Public Date 2022-07-28
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE GENERAL HOSPITAL CORPORATION (USA)
Inventor
  • Love, J. Christopher
  • Martin, Alonso Maria Carmen
  • Bhatia, Sangeeta N.
  • Tabrizi, Shervin
  • Adalsteinsson, Viktor A.
  • Xiong, Kan

Abstract

This disclosure provides a method for substantially increasing the concentration of cfDNA in a patient. By injecting a patient with lipid and/or polymer nanoparticles, agents that bind cfDNA, or inhibit deoxyribonucleases prior to collection of a sample of cfDNA, e.g., by way of a liquid biopsy, major pathways for the degradation of cfDNA are temporarily blocked, permitting transient accumulation of cfDNA. This strategy has the potential to dramatically enhance the quality of detection achieved by downstream cfDNA analytical applications, such as sequencing applications.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6825 - Nucleic acid detection involving sensors
  • C08L 101/12 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
  • G01N 33/551 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic

41.

DNA NUCLEASE GUIDED TRANSPOSASE COMPOSITIONS AND METHODS OF USE THEREOF

      
Document Number 03204429
Status Pending
Filing Date 2022-01-07
Open to Public Date 2022-07-14
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhang, Feng
  • Strecker, Jonathan
  • Faure, Guilhem

Abstract

The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements. Specifically, the disclosure provides an engineered composition comprising: a programmable DNA-binding protein and two or more Tn7-like transposition proteins, wherein at least one of the Tn7-like transposition proteins is connected to the DNA-binding protein or otherwise capable of forming a complex with the DNA-binding protein, wherein the DNA-binding protein comprising a Cas protein including a Cas12k protein, and wherein two or more Tn7-like transposition proteins consisting of TnsB, TnsC, and TniQ.

IPC Classes  ?

  • A61K 38/46 - Hydrolases (3)
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

42.

TOPOLOGICAL QUBITS IN A QUANTUM SPIN LIQUID

      
Document Number 03196700
Status Pending
Filing Date 2021-11-19
Open to Public Date 2022-06-23
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Lukin, Mikhail D.
  • Vuletic, Vladan
  • Greiner, Markus
  • Verresen, Ruben
  • Vishwanath, Ashvin
  • Contreras, Alexander Keesling
  • Levine, Harry Jay
  • Semeghini, Giulia
  • Wang, Tout Taotao
  • Omran, Ahmed
  • Bluvstein, Dolev
  • Ebadi, Sepehr

Abstract

Topological qubits are provided in a quantum spin liquid. In various embodiments, a device is provided comprising a two-dimensional array of particles, each particle disposed at a vertex of a ruby lattice having a parameter ? greater than AA; each particle having a first state and an excited state; each particle that belongs to at least three unit cells of the ruby lattice having a blockade radius, when in the excited state, sufficient to blockade each of at least six nearest neighboring particles in the ruby lattice from transitioning from its first state to its excited state, and wherein the array has at least one outer edge configured to be in a first boundary condition.

IPC Classes  ?

  • G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
  • G06N 10/70 - Quantum error correction, detection or prevention, e.g. surface codes or magic state distillation

43.

ENGINEERED PROBIOTIC COMPOSITIONS AND USES THEREOF

      
Document Number 03199627
Status Pending
Filing Date 2021-12-01
Open to Public Date 2022-06-09
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Cubillos, Andres Fernando
  • Collins, James J.

Abstract

Provided herein are compositions and methods comprising engineered microorganisms and their use for locally degrading an antibiotic in the gastrointestinal tract to prevent or limit death of beneficial flora.

IPC Classes  ?

  • A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
  • A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase

44.

ELECTRICALLY CONDUCTIVE FIREBRICK SYSTEM

      
Document Number 03194701
Status Pending
Filing Date 2021-08-31
Open to Public Date 2022-04-28
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Forsberg, Charles
  • Stack, Daniel C.

Abstract

A thermal energy storage system includes a firebrick checkerwork and an electrode. The firebrick checkerwork includes one or more conductive firebrick layers, each including a plurality of electrically conductive doped metal oxide firebricks with one or more airflow vents. The electrode includes one or more electrode firebrick layers, each layer including a plurality of electrode firebricks. The firebrick checkerwork is heated due to application of electrical power to the electrode. Air flowing through the firebrick checkerwork may then be heated for use in heat-related applications (e.g., an industrial application, commercial application, residential application, transportation application, etc.) some of which may relate to electricity production or in other applications which may relate to other purposes that require heat that are unrelated to electricity production.

IPC Classes  ?

  • F28D 20/00 - Heat storage plants or apparatus in general; Regenerative heat-exchange apparatus not covered by groups or
  • H01M 4/00 - Electrodes

45.

SYSTEMS, METHODS, AND COMPOSITIONS FOR SITE-SPECIFIC GENETIC ENGINEERING USING PROGRAMMABLE ADDITION VIA SITE-SPECIFIC TARGETING ELEMENTS (PASTE)

      
Document Number 03196116
Status Pending
Filing Date 2021-10-21
Open to Public Date 2022-04-28
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Abudayyeh, Omar
  • Gootenberg, Jonathan

Abstract

This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.

IPC Classes  ?

  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 9/22 - Ribonucleases
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

46.

REPROGRAMMABLE ISCB NUCLEASES AND USES THEREOF

      
Document Number 03193961
Status Pending
Filing Date 2021-10-22
Open to Public Date 2022-04-28
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Altae-Tran, Han
  • Kannan, Soumya
  • Demircioglu, Fatma Esra
  • Zhang, Feng

Abstract

Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.

IPC Classes  ?

47.

LOW-POWER EDGE COMPUTING WITH OPTICAL NEURAL NETWORKS VIA WDM WEIGHT BROADCASTING

      
Document Number 03193998
Status Pending
Filing Date 2021-07-29
Open to Public Date 2022-04-28
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Hamerly, Ryan
  • Englund, Dirk Robert

Abstract

NetCast is an optical neural network architecture that circumvents constraints on deep neural network (DNN) inference at the edge. Many DNNs have weight matrices that are too large to run on edge processors, leading to limitations on DNN inference at the edge or bandwidth bottlenecks between the edge and server that hosts the DNN. With NetCast, a weight server stores the DNN weight matrix in local memory, modulates the weights onto different spectral channels of an optical carrier, and distributes the weights to one or more clients via optical links. Each client stores the activations, or layer inputs, for the DNN and computes the matrix-vector product of those activations with the weights from the weight server in the optical domain. This multiplication can be performed coherently by interfering the spectrally multiplexed weights with spectrally multiplexed activations or incoherently by modulating the weight signal from the weight server with the activations.

IPC Classes  ?

  • H04B 10/80 - Optical aspects relating to the use of optical transmission for specific applications, not provided for in groups , e.g. optical power feeding or optical transmission through water

48.

BIOADHESIVE MATERIALS AND MINIMALLY INVASIVE METHODS FOR ADHERING TISSUES WITH BIOADHESIVE MATERIALS

      
Document Number 03195331
Status Pending
Filing Date 2021-10-08
Open to Public Date 2022-04-21
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (MAYO) (USA)
Inventor
  • Zhao, Xuanhe
  • Yuk, Hyunwoo
  • Wu, Sarah J.
  • Nabzdyk, Christoph

Abstract

Bioadhesive materials and methods for adhering biological tissues and blood vessels in a minimally invasive manner, wherein the bioadhesive materials are in folded bioadhesive sleeve configurations or in injectable bioadhesive forms adapted for delivery using minimally invasive procedures. The folded bioadhesive sleeve is disposed on the distal portions of a variety of minimally invasive devices for insertion to a target tissue site, then deployed and adhered to the target tissue site through actuation of the minimally invasive device. The injectable bioadhesive is disposed in a syringe and delivered to a target site via a catheter, then adhered to the target tissue by actuation of a minimally invasive device. Precise placement and adhesion to the target tissue site can be successfully accomplished solely through the actuation of the minimally invasive devices without the use of additional devices to assist in placement or actuation of the bioadhesive materials.

IPC Classes  ?

  • A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
  • A61L 24/00 - Surgical adhesives or cements; Adhesives for colostomy devices
  • A61B 17/072 - Surgical staplers for applying a row of staples in a single action

49.

TYPE I CRISPR-ASSOCIATED TRANSPOSASE SYSTEMS

      
Document Number 03194645
Status Pending
Filing Date 2021-10-08
Open to Public Date 2022-04-14
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhang, Feng
  • Saito, Makoto
  • Strecker, Jonathan

Abstract

Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. The novel nucleic acid targeting systems can comprise components of one or more transposases, one or more components of a CRISPR-Cas system, and a transposable element.

IPC Classes  ?

  • C07K 14/195 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

50.

SYSTEMS, METHODS, AND COMPOSITIONS FOR RNA-GUIDED RNA-TARGETING CRISPR EFFECTORS

      
Document Number 03190991
Status Pending
Filing Date 2021-07-01
Open to Public Date 2022-03-10
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Abudayyeh, Omar
  • Gootenberg, Jonathan

Abstract

This disclosure provides systems, methods, and compositions for RNA-guided RNA- targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.

IPC Classes  ?

51.

SHANK3 GENE THERAPY APPROACHES

      
Document Number 03192052
Status Pending
Filing Date 2021-08-17
Open to Public Date 2022-02-24
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Feng, Guoping
  • Mei, Yuan
  • Gao, Xian

Abstract

Aspects of the disclosure relate to non-naturally occurring polynucleotides encoding a Shank3 protein, AAV vectors comprising the polynucleotides, and gene therapy methods.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C12N 15/864 - Parvoviral vectors

52.

INGESTIBLE DRUG DELIVERY DEVICE

      
Document Number 03188904
Status Pending
Filing Date 2021-08-09
Open to Public Date 2022-02-17
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • NOVO NORDISK A/S (Germany)
Inventor
  • Arrick, Graham
  • Gwynne, Declan
  • Wainer, Jacob
  • Traverso, Carlo Giovanni
  • Sticker, Drago
  • Water, Jorrit Jeroen
  • Mouridsen, Brian
  • Poulsen, Mette
  • Sorensen, Dan Nortoft
  • Jepsen, Jacob Pyung Hwa
  • Cleveland, Cody
  • Ghazal, Aghiad

Abstract

A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.

IPC Classes  ?

  • A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
  • A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M 5/30 - Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or cartridges
  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

53.

COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS

      
Document Number 03185871
Status Pending
Filing Date 2021-07-30
Open to Public Date 2022-02-03
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • MERCK SHARP & DOHME LLC (USA)
Inventor
  • Doyle, Patrick S.
  • Schieferstein, Jeremy
  • Reichert, Paul
  • Narasimhan, Chakravarthy
  • Erfani-Khaneghahi, Amir

Abstract

Compositions including solid forms of polypeptides such as crystalline antibodies, and related methods, are generally described. The compositions may include carriers such as hydrogels that at least partially encapsulate the solid form of the polypeptides (e.g., crystals, amorphous solids). Encapsulation with certain of the materials described may result in compositions containing relatively high loadings of polypeptides while in some instances retaining structural and functional properties of the polypeptides useful for certain types of administration to subjects (e.g., for prophylactic or therapeutic applications). In some instances, compositions having relatively low dynamic viscosities while having relatively high polypeptide loadings are provided.

IPC Classes  ?

  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61L 27/52 - Hydrogels or hydrocolloids

54.

ENGINEERED MUSCLE TARGETING COMPOSITIONS

      
Document Number 03183530
Status Pending
Filing Date 2021-07-22
Open to Public Date 2022-01-27
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sabeti, Pardis
  • Tabebordbar, Mohammadsharif
  • Ye, Simon

Abstract

Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • C12N 15/86 - Viral vectors

55.

SYSTEMS AND METHODS FOR PROCESSING ASH

      
Document Number 03186671
Status Pending
Filing Date 2021-07-21
Open to Public Date 2022-01-27
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • CARNEGIE MELLON UNIVERSITY (USA)
Inventor
  • Chiang, Yet-Ming
  • Ellis, Leah
  • Coppieters 'T Wallant, Sophie C.
  • Zhang, Sonia
  • Viswanathan, Venkatasubramanian
  • Olivetti, Elsa A.
  • Wang, Michael Joseph

Abstract

Disclosed herein are systems and methods for processing ash. For example, in certain embodiments, the method comprises dissolving at least a portion of ash in acid. In some embodiments, the acid is produced in a reactor. In some embodiments, dissolving at least a portion of ash in acid produces refined silica (SiO2) (e.g., amorphous silica, substantially pure silica, and/or a substantial amount of silica). According to certain embodiments, the ash can be further processed (e.g., using electro winning, pH- based precipitation, and/or electrorefining) to obtain other components instead of or in addition to refined silica.

IPC Classes  ?

  • C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
  • C25C 1/20 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of noble metals

56.

CRISPR-ASSOCIATED TRANSPOSASE SYSTEMS AND METHODS OF USE THEREOF

      
Document Number 03178165
Status Pending
Filing Date 2021-06-18
Open to Public Date 2021-12-23
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhang, Feng
  • Strecker, Jonathan
  • Ladha, Alim
  • Faure, Guilhem

Abstract

The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 9/22 - Ribonucleases
  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

57.

CHIMERIC AMPLICON ARRAY SEQUENCING

      
Document Number 03182741
Status Pending
Filing Date 2021-06-14
Open to Public Date 2021-12-23
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE GENERAL HOSPITAL CORPORATION - DBA MASS GENERAL HOSPITAL (USA)
Inventor
  • Al'Khafaji, Aziz
  • Blainey, Paul
  • Babadi, Mehrtash
  • Garimella, Kiran V
  • Hacohen, Nir
  • Smith, Jonathan Theodore

Abstract

The present disclosure relates to compositions and methods for nucleic acid sequencing, and specifically, at least in certain aspects, provides methods and compositions for enhancing the efficacy, throughput and/or yield of known long-range sequencing platforms, by providing chimeric arrays of input sequences. Such arrays of component nucleic acid sequence elements can be prepared via methods that minimize introduction of bias. The application of the current methods to obtain isoform sequencing information, e.g., from patient samples is specifically also provided, as are methods for mitochondrial lineage tracing that employ the instant chimeric amplicon sequencing processes. Methods and systems for array nucleic acid sequence processing and interpretation are also provided.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

58.

ORAL APPLIANCE AND METHOD FOR TREATING SLEEP DISORDERS

      
Document Number 03183014
Status Pending
Filing Date 2021-06-17
Open to Public Date 2021-12-23
Owner
  • UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE GENERAL HOSPITAL CORPORATION D.B.A MASSACHUSETTS GENERAL HOSPITAL (USA)
Inventor
  • Rasalingam, Ravi
  • Ward, Tarsha
  • Roche, Ellen T.
  • Venegas, Jose

Abstract

An oral appliance and method for treating a sleep disorder in a subject are disclosed. The appliance includes, among other elements, a palatal overlay element that engages a portion of the dorsal surface of the subject's tongue, stabilizing the tongue in a superior direction toward the hard palate. The method generally involves stabilizing the dorsal surface of a subject's tongue in a superior direction toward the subject's hard palate.

IPC Classes  ?

  • A61C 5/90 - Oral protectors for use during treatment, e.g. lip or mouth protectors
  • A61F 5/56 - Devices for preventing snoring
  • A61M 16/06 - Respiratory or anaesthetic masks
  • A62B 9/06 - Mouthpieces; Nose-clips

59.

ADHESIVE MATERIAL WITH TRIGGERABLE ON-DEMAND DETACHMENT

      
Document Number 03183108
Status Pending
Filing Date 2021-05-24
Open to Public Date 2021-12-09
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhao, Xuanhe
  • Yuk, Hyunwoo
  • Chen, Xiaoyu

Abstract

An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.

IPC Classes  ?

60.

MIRRORED WINDING PACK FOR STACKED-PLATE SUPERCONDUCTING MAGNETS

      
Document Number 03174303
Status Pending
Filing Date 2021-02-22
Open to Public Date 2021-11-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor Labombard, Brian

Abstract

Magnets and magnet systems include stacked magnet baseplates. Each of the plates includes grooves that contain windings of a conductor (e.g. a high temperature superconductor) that generates a magnetic field when current is passed through. This field generates Lorentz forces in the stack that press the conductors in different directions and with different magnitudes. Thus, the plates are oppositely oriented (mirrored) so that these forces always press the conductors into the grooves, rather than pulling them out of the grooves. The conductors may be further reinforced in their grooves with solder or epoxy potting. Some stacks may have more plates in one orientation than in the mirrored orientation, because the Lorentz forces need not be symmetrical with respect to a midpoint of the stack, e.g. when the system experiences externally-applied magnetic fields. Additional, mirrored side plates may be added in some configurations.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01B 12/02 - Superconductive or hyperconductive conductors, cables or transmission lines characterised by their form
  • H01F 6/04 - Cooling

61.

TECHNIQUES FOR DISTRIBUTING FORCES IN HIGH FIELD MAGNETS AND RELATED SYSTEMS AND METHODS

      
Document Number 03174309
Status Pending
Filing Date 2021-05-20
Open to Public Date 2021-11-25
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Radovinsky, Alexey
  • Zhukovsky, Alexander
  • Kelton, Nicholas J.
  • Kuznetsov, Sergey
  • Nash, Daniel
  • Sanabria, Charlie
  • Labombard, Brian
  • Brunner, Daniel
  • Kristofek, Grant William

Abstract

Techniques are described for lowering strains applied to superconducting material in a superconducting magnet by arranging structural partitions between turns of the superconducting material that intercept and transfer strain to a mechanically stronger structure, such as the housing of the magnet. A structural partition may be formed with a feedthrough slit so that the superconducting material can easily pass through the partition. A number of structural partitions may be interspersed between groups of turns of superconducting material in a magnet so that forces can be sufficiently distributed by the partitions throughout the magnet. At the same time, the number of structural partitions may be selected to minimize the amount of space within the magnet occupied by the partitions that could otherwise be occupied by current-carrying superconducting material.

IPC Classes  ?

  • H01F 6/04 - Cooling
  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils
  • H01F 6/02 - Quenching; Protection arrangements during quenching

62.

COMPOSITIONS OF POLYMERIC MICRODEVICES AND THEIR USE IN CANCER IMMUNOTHERAPY

      
Document Number 03178260
Status Pending
Filing Date 2021-05-11
Open to Public Date 2021-11-18
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Langer, Robert S.
  • Jaklenec, Ana
  • Lu, Xueguang

Abstract

Microparticulate compositions and methods for delivery and pulsatile release of one or more sting agonists and/or receptors have been developed. The compositions include polymeric microdevices formed from biodegradable and biocompatible polymers or co-polymers thereof including a shell and compartment(s) or discrete regions in the compartment(s) formed by an additive process such as micromolding, three-dimensional printing and lithography. The compositions include microdevices that release individual doses of incorporated STING agonist and/or receptors at defined times, for example, in pulses up to several months after administration with essentially no leakage between releases.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/50 - Microcapsules
  • A61K 31/7084 - Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
  • A61P 35/00 - Antineoplastic agents

63.

ENGINEERED CENTRAL NERVOUS SYSTEM COMPOSITIONS

      
Document Number 03176506
Status Pending
Filing Date 2021-04-30
Open to Public Date 2021-11-04
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sabeti, Pardis
  • Tabebordbar, Mohammadsharif
  • Ye, Simon

Abstract

Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of a n-mer motif, P motif, or both. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.

IPC Classes  ?

  • C07K 11/00 - Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
  • C12N 15/86 - Viral vectors

64.

USE OF REACTOR OUTPUTS TO PURIFY MATERIALS, AND RELATED SYSTEMS

      
Document Number 03181593
Status Pending
Filing Date 2021-04-29
Open to Public Date 2021-11-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Chiang, Yet-Ming
  • Ellis, Leah

Abstract

Disclosed herein are methods of using reactor outputs to purify materials. For example, methods of using acid and/or base produced in a reactor to purify materials (e.g., limestone, dolomite, waste streams, and/or ash) are described herein. Related systems are also described.

IPC Classes  ?

  • C01B 13/00 - Oxygen; Ozone; Oxides or hydroxides in general
  • C01F 11/00 - Compounds of calcium, strontium, or barium
  • C22B 3/02 - Apparatus therefor
  • C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
  • C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof

65.

MULTI-MATERIAL FIBERS AND METHODS OF MANUFACTURING THE SAME

      
Document Number 03182896
Status Pending
Filing Date 2021-04-21
Open to Public Date 2021-10-28
Owner
  • ADVANCED FUNCTIONAL FABRICS OF AMERICA, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Chung, Chia-Chun
  • Cox, Jason
  • Deisenhaus, Joshua
  • Mccarthy, Kristina
  • Mulherin, Kristen
  • Nguyen, Jimmy
  • Rein, Michael
  • Bernasconi, Matthew
  • Cantley, Lauren
  • Parameswaran, Lalitha
  • Rickley, Michael
  • Stolyarov, Alexander

Abstract

Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.

IPC Classes  ?

  • B29C 70/88 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts characterised primarily by possessing specific properties, e.g. electrically conductive or locally reinforced
  • D01D 5/00 - Formation of filaments, threads, or the like
  • H01B 1/14 - Conductive material dispersed in non-conductive inorganic material
  • H01B 1/20 - Conductive material dispersed in non-conductive organic material
  • H01B 13/14 - Insulating conductors or cables by extrusion

66.

CONDUCTOR AND COOLANT SCHEMES FOR SPIRAL-GROOVED, STACKED PLATE, NON-INSULATED SUPERCONDUCTING MAGNETS

      
Document Number 03167302
Status Pending
Filing Date 2021-03-25
Open to Public Date 2021-09-30
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Labombard, Brian
  • Mumgaard, Robert
  • Beck, William
  • Doody, Jeffrey
  • Vieira, Rui
  • Leccacorvi, Richard C.

Abstract

Schemes are described for conductor and coolant placement in stacked-plate superconducting magnets, including arranging coolant channels and conducting channels within the plates on opposing faces. If the two types of channels are aligned with one another across the plate stacks, the plates may be stacked such that the cooling channel in one plate is adjacent to the conducting channel of the neighboring plate. By stacking a number of these plates, therefore, cooling may be supplied to each conducting channel through the cooling channels of each neighboring plate. Moreover, by aligning the two types of channels, the stacks of plates may have improved mechanical strength because mechanical load paths through the entire stack that do not pass through any of the channels may be created. This arrangement of channels may produce a very strong stack of plates that can withstand high Lorentz loads.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils

67.

PASSIVE QUENCH PROTECTION TECHNIQUES FOR NON-INSULATED SUPERCONDUCTING MAGNETS

      
Document Number 03173407
Status Pending
Filing Date 2021-03-25
Open to Public Date 2021-09-30
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Labombard, Brian
  • Uppalapati, Krishna Kiran

Abstract

According to some aspects, techniques are described for designing non-insulated (NI) high temperature superconductor (HTS) magnets that mitigate problems that may arise during quench initiation and propagation. Coupling the HTS material to a co-conductor along its length reduces the effective resistance of the conductive path along the HTS material when it is not superconducting, and that this leads to numerous advantages for quench mitigation.

IPC Classes  ?

68.

BODY FLUID RESISTANT TISSUE ADHESIVES

      
Document Number 03163247
Status Pending
Filing Date 2020-12-03
Open to Public Date 2021-09-30
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventor
  • Zhao, Xuanhe
  • Yuk, Hyunwoo
  • Mao, Xinyu
  • Nabzdyk, Christoph

Abstract

A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.

IPC Classes  ?

  • C09J 9/00 - Adhesives characterised by their physical nature or the effects produced, e.g. glue sticks
  • A61L 24/00 - Surgical adhesives or cements; Adhesives for colostomy devices
  • C09J 11/00 - Features of adhesives not provided for in group , e.g. additives
  • C09J 105/08 - Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
  • C09J 151/08 - Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • C09J 183/04 - Polysiloxanes

69.

METHODS FOR GENERATING ENGINEERED MEMORY-LIKE NK CELLS AND COMPOSITIONS THEREOF

      
Document Number 03173527
Status Pending
Filing Date 2021-03-10
Open to Public Date 2021-09-16
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • DANA-FARBER CANCER INSITUTE, INC. (USA)
Inventor
  • Chen, Jianzhu
  • Ritz, Jerome
  • Romee, Rizwan
  • Dong, Han
  • Xie, Guozhu
  • Ham, James Dongjoo

Abstract

The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.

IPC Classes  ?

  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
  • A61P 35/00 - Antineoplastic agents
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

70.

COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1C-POSITIVE CANCER

      
Document Number 03173981
Status Pending
Filing Date 2021-01-08
Open to Public Date 2021-09-16
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Chen, Jianzhu
  • Xie, Guozhu

Abstract

The present disclosure relates to compounds (e.g., antibodies, antigen-binding fragments thereof, bispecific molecules, or chimeric antigen receptor polypeptides) that bind to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.

IPC Classes  ?

  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • C07K 14/725 - T-cell receptors
  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

71.

PARTITIONED SUPERCONDUCTING CABLE

      
Document Number 03170080
Status Pending
Filing Date 2021-03-04
Open to Public Date 2021-09-10
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Radovinsky, Alexey
  • Sanabria, Charlie
  • Craighill, Christopher
  • Uppalapati, Krishna Kiran
  • Creely, Alexander
  • Brunner, Daniel

Abstract

Described is a cable comprising a plurality of high temperature superconductor (HTS) components, a plurality of electrically conductive segments extending along a length of the cable, each of the plurality of electrically conductive segments comprising one of the plurality of HTS components, and an electrically insulating material arranged between adjacent ones of the plurality of electrically conductive segments.

IPC Classes  ?

  • H01B 12/02 - Superconductive or hyperconductive conductors, cables or transmission lines characterised by their form
  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

72.

SYSTEMS AND METHODS FOR THE INJECTION OF VISCOUS FLUIDS

      
Document Number 03169638
Status Pending
Filing Date 2021-01-28
Open to Public Date 2021-08-05
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Varanasi, Kripa, K.
  • Jayaprakash, Vishnu
  • Costalonga, Maxime

Abstract

Disclosed herein are systems and methods for the injection of viscous fluids. For example, inventive systems and methods for injecting viscous fluids, such as concentrated drug formulations, via droplet lubrication are described.

IPC Classes  ?

  • A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

73.

METHODS OF FUNCTIONALLY SCREENING BIOLOGICAL SEQUENCE FRAGMENTS

      
Document Number 03168017
Status Pending
Filing Date 2021-01-23
Open to Public Date 2021-07-29
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Esvelt, Kevin Michael
  • Gretton, Dana

Abstract

The invention relates, in part, to methods of accurately and reliably detecting biological sequences corresponding to a particular function.

IPC Classes  ?

  • G16B 35/20 - Screening of libraries
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 35/10 - Design of libraries
  • G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics

74.

TISSUE CATALYZED GROWTH OF POLYMER AS EPITHELIAL LININGS FOR THERAPY

      
Document Number 03160333
Status Pending
Filing Date 2020-12-10
Open to Public Date 2021-06-17
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (USA)
Inventor
  • Langer, Robert S.
  • Traverso, Carlo Giovanni
  • Li, Junwei
  • Wang, Thomas
  • Shi, Yunhua
  • Kirtane, Ameya R.

Abstract

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
  • A61L 24/06 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 24/08 - Polysaccharides
  • A61L 31/04 - Macromolecular materials
  • A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 31/14 - Materials characterised by their function or physical properties

75.

SYNTHETIC TISSUE BARRIERS AND USES THEREOF

      
Document Number 03160347
Status Pending
Filing Date 2020-12-10
Open to Public Date 2021-06-17
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (USA)
Inventor
  • Traverso, Carlo Giovanni
  • Kirtane, Ameya R.
  • Li, Junwei
  • Byrne, James
  • Jones, Alexis
  • Wang, Thomas

Abstract

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
  • A61L 24/06 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 24/08 - Polysaccharides
  • A61L 31/04 - Macromolecular materials
  • A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 31/14 - Materials characterised by their function or physical properties

76.

HIGH-PERFORMANCE LADDER POLYMERS FOR MEMBRANE GAS SEPARATION

      
Document Number 03158913
Status Pending
Filing Date 2020-10-23
Open to Public Date 2021-05-27
Owner
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Lai, Holden Wan Hong
  • Ahn, Jun Myun
  • Xia, Yan
  • Smith, Zachary P.
  • Benedetti, Francesco M.

Abstract

Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation.

IPC Classes  ?

  • C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
  • B01D 71/62 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors
  • C08G 73/10 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors

77.

PROCESSES, SYSTEMS AND DEVICES FOR METAL FILLING OF HIGH TEMPERATURE SUPERCONDUCTOR CABLES

      
Document Number 03157291
Status Pending
Filing Date 2020-11-12
Open to Public Date 2021-05-20
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Hubbard, Amanda
  • Irby, James
  • Vieira, Rui
  • Beck, William
  • Murray, Richard
  • Pfeiffer, Andrew
  • Toland, Thomas
  • Burke, William

Abstract

Techniques described herein relate to systems and methods for obtaining a high temperature superconducting (HTS) cable assembly and filling the HTS cable assembly with a molten metal, such as solder.

IPC Classes  ?

  • H01B 12/02 - Superconductive or hyperconductive conductors, cables or transmission lines characterised by their form
  • H01B 12/06 - Films or wires on bases or cores

78.

TREATMENT OF ACID GASES USING MOLTEN ALKALI METAL BORATES AND ASSOCIATED METHODS OF SEPARATION, AND PROCESSES FOR REGENERATING SORBENTS AND ASSOCIATED SYSTEMS

      
Document Number 03160467
Status Pending
Filing Date 2020-11-05
Open to Public Date 2021-05-14
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Hatton, Trevor Alan
  • Harada, Takuya
  • Halliday, Cameron G.

Abstract

The removal of acid gases (e.g., non-carbon dioxide acid gases) using non-COi acid gas sorbents that include salts in molten form, and related systems and methods, are generally described. Processes for regenerating sorbents at high temperatures, and associated systems, are also generally described.

IPC Classes  ?

  • B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
  • B01D 53/50 - Sulfur oxides
  • B01D 53/52 - Hydrogen sulfide
  • B01D 53/56 - Nitrogen oxides
  • B01D 53/78 - Liquid phase processes with gas-liquid contact
  • B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
  • B01J 20/30 - Processes for preparing, regenerating or reactivating

79.

LASER-ASSISTED MATERIAL PHASE-CHANGE AND EXPULSION MICRO-MACHINING PROCESS

      
Document Number 03158185
Status Pending
Filing Date 2020-11-08
Open to Public Date 2021-05-14
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Patil, Prashant
  • Gershenfeld, Neil Adam

Abstract

A laser micro-machining process called laser-assisted material phase-change and expulsion (LAMPE) micromachining that includes cutting features in a cutting surface of a piece of material using a pulsed laser with intensity, pulse width and pulse rate set to melt and eject liquid material without vaporizing said material, or, in the case of silicon, create an ejectible silicon oxide. Burrs are removed from the cutting surface by electro-polishing the cutting surface with a dilute acid solution using an electric potential higher than a normal electro-polishing electric potential. A multi-lamina assembly of laser-micro-machined laminates (MALL) may utilize MEMS. In the MALL process, first, the individual layers of a micro-electromechanical system (MEMS) are fabricated using the LAMPE micro-machining process. Next, the fabricated microstructure laminates are stack assembled and bonded to fabricate MEM systems. The MALL MEMS fabrication process enables greater material section and integration, greater design flexibility, low-cost manufacturing, rapid development, and integrated packaging.

IPC Classes  ?

  • B23K 26/00 - Working by laser beam, e.g. welding, cutting or boring
  • B23K 3/00 - Tools, devices, or special appurtenances for soldering, e.g. brazing, or unsoldering, not specially adapted for particular methods
  • B23K 26/38 - Removing material by boring or cutting
  • B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
  • B81B 7/02 - Microstructural systems containing distinct electrical or optical devices of particular relevance for their function, e.g. microelectro-mechanical systems (MEMS)

80.

TYPE I-B CRISPR-ASSOCIATED TRANSPOSASE SYSTEMS

      
Document Number 03156199
Status Pending
Filing Date 2020-10-30
Open to Public Date 2021-05-06
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Saito, Makoto
  • Zhang, Feng
  • Faure, Guilhem

Abstract

Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements.

IPC Classes  ?

  • C12N 9/22 - Ribonucleases
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 35/76 - Viruses; Subviral particles; Bacteriophages
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • A61P 31/04 - Antibacterial agents
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

81.

BIOMATERIAL-BASED COMPOSITIONS TO DELIVER PLANT GROWTH PROMOTING MICROBES

      
Document Number 03155795
Status Pending
Filing Date 2020-10-21
Open to Public Date 2021-04-29
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Marelli, Benedetto
  • Zvinavashe, Augustine

Abstract

The use of biological fertilizer combined with microbes can be used instead of herbicides, pesticides and synthetic fertilizers. Silk and trehalose dry films can be used as seed coatings to localize and quantify delivery of plant microbes to mitigate plant stress and soil salinity. Similar microbes can be delivered using the same technology.

IPC Classes  ?

82.

BRUSH PRODRUGS AND USES THEREOF

      
Document Number 03154334
Status Pending
Filing Date 2020-10-15
Open to Public Date 2021-04-22
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Johnson, Jeremiah A.
  • Jiang, Yivan
  • Nguyen, Hung Vanthanh

Abstract

The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.

IPC Classes  ?

  • C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
  • A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
  • C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers

83.

ENGINEERED MUSCLE TARGETING COMPOSITIONS

      
Document Number 03153902
Status Pending
Filing Date 2020-10-16
Open to Public Date 2021-04-22
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sabeti, Pardis
  • Tabebordbar, Mohammadsharif
  • Ye, Simon

Abstract

Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.

IPC Classes  ?

  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
  • C07K 14/015 - Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • C12N 15/12 - Genes encoding animal proteins
  • C12N 15/33 - Genes encoding viral proteins
  • C12N 15/35 - Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
  • C12N 15/864 - Parvoviral vectors

84.

NOVEL TYPE VI CRISPR ENZYMES AND SYSTEMS

      
Document Number 03151563
Status Pending
Filing Date 2020-09-18
Open to Public Date 2021-03-25
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhang, Feng
  • Altae-Tran, Han
  • Kannan, Soumya

Abstract

The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides Cas proteins and their use in modifying target sequences.

IPC Classes  ?

  • C12N 9/22 - Ribonucleases
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

85.

ADAPTIVE VOLUTES FOR CENTRIFUGAL PUMPS

      
Document Number 03152956
Status Pending
Filing Date 2020-09-18
Open to Public Date 2021-03-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Johnson, Hilary A.
  • Slocum, Alexander H.
  • Simon, Kevin P.

Abstract

Centrifugal pump systems and related methods are disclosed herein that can shift a best efficiency point of a pump based on one or more operating conditions to operate more efficiently across and/or adjust to a broader range of conditions. Pumps provided for herein can include an adaptive volute in which a geometry of the volute can be adjusted to shift an operating efficiency of the pump. In some embodiments, a height or radial dimension of the adaptive volute can be adjusted based on one or more operating condition. A geometry of the adaptive volute can be adjusted during operation of the pump and/or while an impeller is disposed within the volute. In some embodiments, a first and second collar can be disposed within the adaptive volute. Rotation of the first component can move the second component axially, which can expand or contract an axial dimension of the adaptive volute.

IPC Classes  ?

  • F04D 29/42 - Casings; Connections for working fluid for radial or helico-centrifugal pumps
  • F04D 15/00 - Control, e.g. regulation, of pumps, pumping installations, or systems
  • F04D 29/46 - Fluid-guiding means, e.g. diffusers adjustable

86.

COMPOSITIONS AND METHODS FOR DELIVERING CARGO TO A TARGET CELL

      
Document Number 03151620
Status Pending
Filing Date 2020-09-18
Open to Public Date 2021-03-25
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhang, Feng
  • Segel, Michael

Abstract

Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more endogenous retroviral elements for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more endogenous retroviral elements for forming a delivery vesicle may comprise two or more of a retroviral gag protein, a retroviral envelope protein, a retroviral reverse transcriptase or a combination thereof. The retroviral gag protein alone, the retroviral envelope protein alone, or both the retroviral gag protein and retroviral envelope protein may be endogenous.

IPC Classes  ?

  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

87.

DEVICES AND METHODS FOR THE INTEGRATED FILTRATION, DRYING, AND MECHANICAL PROCESSING OF ACTIVE PHARMACEUTICAL INGREDIENTS

      
Document Number 03153544
Status Pending
Filing Date 2020-08-17
Open to Public Date 2021-03-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Brancazio, David
  • Myerson, Allan S.
  • Azad, Mohammad A.
  • Hammersmith, Gregory J.
  • Capellades Mendez, Gerard
  • Neurohr, Clemence
  • Rapp, Kersten
  • Briggs, Naomi Elizabeth Barbara

Abstract

Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.

IPC Classes  ?

  • B01D 29/86 - Retarding cake deposition on the filter during the filtration period, e.g. using stirrers
  • B01D 29/03 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ;   Filtering elements therefor with flat filtering elements self-supporting
  • B01D 29/60 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ;   Filtering elements therefor integrally combined with devices for controlling the filtration
  • B01D 35/18 - Heating or cooling the filters

88.

SYSTEMS, COMPOSITIONS, AND METHODS FOR PRODUCING SHARP EDGES

      
Document Number 03154861
Status Pending
Filing Date 2020-09-18
Open to Public Date 2021-03-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Roscioli, Gianluca
  • Tasan, Cemal Cem

Abstract

The present disclosure is directed to systems, compositions, and methods for manufacturing objects with sharp edges having a high strength and hardness. To form the sharp edge, an object can be subjected to a compressive force that locally deforms the object to create the sharp edge. In some embodiments, deformation can occur by passing the material through a system of one or more opposed tapered rolls having one or more tapering angles for deforming the material. The tapered rolls can rotate and drive the material downstream to a next opposed pair of tapered rolls. The tapered rolls deform the material by changing the material microstructure, compressing the grains of the material in a predetermined location to create a more homogeneous microstructure. The local modification of the resulting microstructure increases the homogeneity as well as the hardness and strength of the material and prevents cracking and/or chipping of the material.

IPC Classes  ?

  • B24B 3/00 - Sharpening cutting edges, e.g. of tools; Accessories therefor, e.g. for holding the tools
  • C21D 7/00 - Modifying the physical properties of iron or steel by deformation
  • C22F 1/08 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of copper or alloys based thereon

89.

ENGINEERED ADENO-ASSOCIATED VIRUS CAPSIDS

      
Document Number 03148356
Status Pending
Filing Date 2020-09-11
Open to Public Date 2021-03-18
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Sabeti, Pardis
  • Tabebordbar, Mohammadsharif
  • Ye, Simon

Abstract

Described herein are methods of generating engineered viral capsid variants. Also described herein are engineered viral capsid variants, engineered viral particles and formulations and cells thereof. Also described herein are vector systems containing an engineered viral capsid polynucleotide and uses thereof.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
  • C12N 15/86 - Viral vectors

90.

ELECTROCHEMICAL CAPTURE OF LEWIS ACID GASES

      
Document Number 03152778
Status Pending
Filing Date 2020-08-27
Open to Public Date 2021-03-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Voskian, Sahag
  • Hatton, Trevor Alan
  • Halliday, Cameron G.

Abstract

Methods, apparatuses, and systems related to electrochemical capture of Lewis acid gases from fluid mixtures are generally described. Certain embodiments are related to electrochemical methods involving selectively removing a first Lewis acid gas from a fluid mixture containing multiple types of Lewis acid gases (e.g., a first Lewis acid gas and a second Lewis acid gas). Certain embodiments are related to electrochemical systems comprising certain types of electro active species having certain redox states in which the species is capable of binding a first Lewis acid gas but for which binding with a second Lewis acid gas is thermodynamically and/or kinetically unfavorable. The methods, apparatuses, and systems described herein may be useful in carbon capture and pollution mitigation applications.

IPC Classes  ?

  • B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
  • B01D 53/50 - Sulfur oxides
  • B01D 53/56 - Nitrogen oxides
  • B01D 53/62 - Carbon oxides

91.

ELECTROCHEMICALLY MEDIATED GAS CAPTURE, INCLUDING FROM LOW CONCENTRATION STREAMS

      
Document Number 03152518
Status Pending
Filing Date 2020-08-27
Open to Public Date 2021-03-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Voskian, Sahag
  • Hatton, Trevor Alan

Abstract

Methods, apparatuses, and systems related to the electrochemical separation of target gases from gas mixtures are provided. In some cases, a target gas such as carbon dioxide is captured and optionally released using an electrochemical cell (e.g., by bonding to an electroactive species in a reduced state). Some embodiments are particularly useful for selectively capturing the target gas while reacting with little to no oxygen gas that may be present in the gas mixture. Some such embodiments may be useful in applications involving separations from gas mixtures having relatively low concentrations of the target gas, such as direct air capture and ventilated air treatment.

IPC Classes  ?

  • B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
  • B01D 53/62 - Carbon oxides

92.

SYSTEMS AND METHODS FOR PORTABLE ULTRASOUND GUIDED CANNULATION

      
Document Number 03151345
Status Pending
Filing Date 2020-08-17
Open to Public Date 2021-02-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Brattain, Laura J.
  • Samir, Anthony E.
  • Telfer, Brian A.
  • Delosa, Nancy
  • Gjesteby, Lars
  • Pierce, Theodore T.
  • Johnson, Matthew
  • Hill, Westin
  • Chamorro, Andres

Abstract

Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for segmentation of vessels of interest from image data. The image analysis provides for guidance for insertion of a cannulation system into a subject which may be accomplished by a non-expert based upon the guidance provided. The guidance may include an indicator or a mechanical guide to guide a user for inserting the vascular cannulation system into a subject to penetrate the vessel of interest.

IPC Classes  ?

  • A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
  • A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

93.

TARGETED TRANS-SPLICING USING CRISPR/CAS13

      
Document Number 03150747
Status Pending
Filing Date 2020-08-14
Open to Public Date 2021-02-25
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor Borrajo, Jacob

Abstract

This disclosure provides compositions and methods of using these compositions to mediate a targeted trans-splicing event on a pre-mRNA in a cell.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • A61K 38/46 - Hydrolases (3)
  • C12N 9/22 - Ribonucleases
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

94.

ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS

      
Document Number 03148226
Status Pending
Filing Date 2020-08-12
Open to Public Date 2021-02-18
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (USA)
Inventor
  • Traverso, Carlo Giovanni
  • Korzenik, Joshua
  • Langer, Robert S.
  • Steiger, Christoph Winfried Johannes

Abstract

Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.

IPC Classes  ?

  • A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

95.

ULTRA-WIDE FIELD-OF-VIEW FLAT OPTICS

      
Document Number 03146753
Status Pending
Filing Date 2020-06-08
Open to Public Date 2021-02-11
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Hu, Juejun
  • Gu, Tian
  • Shalaginov, Mikhail

Abstract

Wide-angle optical functionality is beneficial for imaging and image projection devices. Conventionally, wide-angle operation is attained by a complicated assembly of optical elements. Recent advances have led to meta-surface lenses or meta-lenses, which are ultra-thin planar lenses with nanoantennas that control the phase, amplitude, and/or polarization of light. Here, we present a meta-lens capable of diffraction-limited focusing and imaging over an unprecedented >170° angular field of view (FOV). The lens is integrated on a one-piece flat substrate and includes an aperture on one side and a single meta-surface on the other side. The meta-surface corrects third- order Seidel aberrations, including coma, astigmatism, and field curvature. The meta-lens has a planar focal plane, which enables considerably simplified system architectures for imaging and projection. The meta-lens design is generic and can be readily adapted to different meta-atom geometries and wavelength ranges to meet diverse application demands.

IPC Classes  ?

  • G02B 1/00 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements
  • B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
  • G02B 5/00 - Optical elements other than lenses
  • G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour

96.

SYNTHETIC HYDROGELS FOR ORGANOGENESIS

      
Document Number 03148127
Status Pending
Filing Date 2020-07-29
Open to Public Date 2021-02-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Griffith, Linda G.
  • Hernandez-Gordillo, Victor

Abstract

Synthetic hydrogels for organogenesis support organogenesis from mammalian cells, including human cells. The synthetic hydrogels typically include a network of crosslinked branched biodegradable polymers. A portion of the branches of the branched biodegradable polymers are linked to binders which are generally synthetic peptides for cell and extracellular matrix attachment. The hydrogels may include an inhibitor of apoptosis. The synthetic hydrogels with the synthetic binders typically do not interfere with cellular, proteomic, genetic, and/or transcriptome analyses of organoids formed in the hydrogel. The synthetic hydrogels may be subject to on-demand dissolution to provide intact organoids substantially free of hydrogel polymers. Also provided are methods of making the synthetic hydrogels and methods of using the synthetic hydrogels for organogenesis.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C08J 3/075 - Macromolecular gels
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

97.

SYSTEM AND METHOD FOR PARALLEL IMPLEMENTATION OF MULTI-QUBIT QUANTUM GATES

      
Document Number 03144798
Status Pending
Filing Date 2020-07-10
Open to Public Date 2021-01-14
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Pichler, Hannes
  • Levine, Harry Jay
  • Lukin, Mikhail D.
  • Omran, Ahmed
  • Vuletic, Vladan
  • Greiner, Markus
  • Keesling Contreras, Alexander
  • Ebadi, Sepehr
  • Semeghini, Giulia
  • Wang, Tout

Abstract

A device includes a grouping of N qubits, where N is equal to two or more, and a coherent light source configured to, given selected values for a set of parameters of at least a first and a second laser pulse, the parameters selected from a relative phase shift, a laser frequency, a laser intensity, and a pulse duration: apply at least the first and second laser pulses to all qubits within the grouping of N qubits, thereby coupling a non-interacting quantum state |1> to an interacting excited state |r), such that each qubit that begins in quantum state |1) returns to the state |1) upon completion of the at least first and second laser pulses, and such that qubits in the grouping are mutually blockaded.

IPC Classes  ?

  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

98.

BORONIC ESTER PRODRUGS AND USES THEREOF

      
Document Number 03138086
Status Pending
Filing Date 2020-03-20
Open to Public Date 2020-11-26
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • DANA-FARBER CANCER INSTITUTE, INC. (USA)
Inventor
  • Ghoroghchian, Paiman
  • Ghobrial, Irene
  • Johnson, Jeremiah A.
  • Jiang, Yivan
  • Nguyen, Hung Vanthanh
  • Detappe, Alexandre

Abstract

Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.

IPC Classes  ?

  • A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
  • A61P 35/00 - Antineoplastic agents
  • C07F 5/02 - Boron compounds
  • C08F 8/00 - Chemical modification by after-treatment
  • C08F 32/08 - Homopolymers or copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings
  • C08F 290/06 - Polymers provided for in subclass
  • C08G 65/329 - Polymers modified by chemical after-treatment with organic compounds

99.

SYSTEM AND METHOD FOR MULTIPLEXED OPTICAL ADDRESSING OF ATOMIC MEMORIES

      
Document Number 03138309
Status Pending
Filing Date 2020-05-15
Open to Public Date 2020-11-26
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Christen, Ian Robert
  • Englund, Dirk R.
  • Bernien, Hannes
  • Omran, Ahmed
  • Keesling Contreras, Alexander
  • Levine, Harry Jay
  • Lukin, Mikhail D.

Abstract

A system for optically modulating a plurality of optical channels includes a power delivery module adapted to convert a coherent light beam into a plurality of optical channels, at least one optical modulator, optically coupled to the power delivery module, the at least one optical modulator adapted to optically modulate each of the plurality of the optical channels, and a vacuum chamber having a trapping plane therein, the vacuum chamber adapted to generate an addressable array of trapped particles at the trapping plane, wherein each of the plurality of optical channels is optically coupled to at least one of the trapped particles of the addressable array.

IPC Classes  ?

  • G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
  • G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
  • G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
  • G02B 27/10 - Beam splitting or combining systems

100.

LIGAND DISCOVERY AND GENE DELIVERY VIA RETROVIRAL SURFACE DISPLAY

      
Document Number 03140115
Status Pending
Filing Date 2020-03-23
Open to Public Date 2020-11-26
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Birnbaum, Michael
  • Dobson, Connor

Abstract

Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non- viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.

IPC Classes  ?

  • C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
  • C12N 5/07 - Animal cells or tissues
  • C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
  • C12N 15/12 - Genes encoding animal proteins
  • C12N 15/62 - DNA sequences coding for fusion proteins
  • C12N 15/867 - Retroviral vectors
  • C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C40B 40/02 - Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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