Massachusetts Institute of Technology

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1.

Biosensors in Human Gut Organoids

      
Application Number 18432439
Status Pending
Filing Date 2024-02-05
First Publication Date 2024-07-04
Owner
  • The General Hospital Corporation (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Fasano, Alessio
  • Lu, Timothy K.
  • Senger, Stefania
  • Inda, Maria Eugenia

Abstract

Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

2.

SYNTHETIC TISSUE BARRIERS AND USES THEREOF

      
Application Number 18596376
Status Pending
Filing Date 2024-03-05
First Publication Date 2024-07-04
Owner
  • Massachusetts Institute of Technology (USA)
  • The Brigham and Women's Hospital, Inc. (USA)
Inventor
  • Traverso, Carlo Giovanni
  • Kirtane, Ameya R.
  • Li, Junwei
  • Wang, Thomas
  • Byrne, James
  • Jones, Alexis

Abstract

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
  • A61L 24/06 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 24/08 - Polysaccharides
  • A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • A61L 27/20 - Polysaccharides
  • C12N 9/08 - Oxidoreductases (1.), e.g. luciferase acting on hydrogen peroxide as acceptor (1.11)

3.

MILLIMETER-WAVE DIRECTED-ENERGY EXCAVATION

      
Application Number US2023081543
Publication Number 2024/144961
Status In Force
Filing Date 2023-11-29
Publication Date 2024-07-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Cohn, Daniel
  • Woskov, Paul, P.
  • Einstein, Herbert
  • Oglesby, Kenneth

Abstract

Apparatus and methods are described for excavating earthen material with millimeter- wave (MMW) radiation or a combination of MMW radiation and mechanical apparatus. The MMW radiation can reduce costs and hazards associated with excavation using mechanical means only and/or explosives. MMW-assisted excavation has significant energy advantages over optical or long- wavelength microwave excavation techniques.

4.

Systems and Methods for Delivery of Light With Increased Omnidirectionality

      
Application Number 17905806
Status Pending
Filing Date 2021-03-12
First Publication Date 2024-07-04
Owner
  • The General Hospital Corporation (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Yun, Seok-Hyun
  • Dannenberg, Paul

Abstract

A laser microparticle for generating laser light with high omnidirectionality, including: an optical cavity including an active gain material capable of supporting one or more lasing cavity modes: and an optical scattering element which is incorporated into the optical cavity and configured to change a radiation pattern of the one or more lasing cavity modes to increase omnidirectionality of the radiation pattern, the size of the microparticle being less than 10 pm in each dimension.

IPC Classes  ?

  • H01S 5/10 - Construction or shape of the optical resonator

5.

BIODEGRADABLE LIPIDS AND FORMULATIONS FOR INTRAMUSCULAR, IN VITRO, AND EX VIVO TRANSFECTION OF MRNA

      
Application Number US2023085902
Publication Number 2024/145281
Status In Force
Filing Date 2023-12-26
Publication Date 2024-07-04
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • CHILDREN'S MEDICAL CENTER CORPORATION (USA)
Inventor
  • Anderson, Daniel, Griffith
  • Rudra, Arnab
  • Gupta, Akash
  • Reed, Kaelan

Abstract

Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).

IPC Classes  ?

  • C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
  • A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
  • A61P 3/00 - Drugs for disorders of the metabolism
  • A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
  • A61P 11/00 - Drugs for disorders of the respiratory system
  • A61P 19/00 - Drugs for skeletal disorders
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 25/04 - Centrally acting analgesics, e.g. opioids
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
  • A61P 35/00 - Antineoplastic agents
  • A61P 37/00 - Drugs for immunological or allergic disorders

6.

LOW COST, ROBUST AND HIGH SENSITIVITY ION-CONDUCTING POLYCRYSTALLINE RADIATION DETECTORS

      
Application Number US2023086168
Publication Number 2024/145434
Status In Force
Filing Date 2023-12-28
Publication Date 2024-07-04
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Tuller, Harry, L.
  • Defferriere, Thomas
  • Rupp, Jennifer, Lilia Marguerite
  • Li, Ju
  • Elwakeil, Ahmed, Sami Helal Ali

Abstract

A detector for gamma irradiation comprises an oxygen ion conducting polycrystalline solid, has positively charged grain boundaries and is coupled to electrodes that measure changes in the poly crystalline solid's ionic conductance. The poly crystalline solid may include lightly doped Gd-doped CeCh, a polycrystalline ion conducting ceramic. The steady state passivation of space charge barriers at grain boundaries that may act as virtual electrodes, capturing radiation-induced electrons, in turn lowering space charge barrier heights, and thereby exclusively modulating the ionic carrier flow within the ceramic electrolytes. Such behavior may allow for an electrical response under low fields, i.e., < 2 V/cm. The polycrystalline solids disclosed herein may be used in inexpensive, sensitive, low-power and miniaturizable solid- state devices, uniquely suited for operating in harsh (high temperature, high humidity, pressure, and/or corrosive) environments.

IPC Classes  ?

  • H01J 43/04 - Electron multipliers
  • G01N 23/06 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption

7.

SYSTEMS AND METHODS FOR EFFICIENT DATASET DISTILLATION USING NON-DETERMINISTIC FEATURE APPROXIMATION

      
Application Number 18199825
Status Pending
Filing Date 2023-05-19
First Publication Date 2024-06-27
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Loo, Noel
  • Hasani, Ramin
  • Amini, Alexander A.
  • Rus, Daniela

Abstract

Dataset distillation compresses large datasets into smaller synthetic coresets that retain performance with the aim of reducing storage and computational burdens of processing an original, entire dataset. The present disclosure provides an improved algorithm that uses a non-deterministic feature approximation of neural network Gaussian process (NNGP) kernels, or other trained kernels, that reduces a kernel matrix computation to O(|S|). When combined with a modified Platt scaling loss, the disclosed algorithm can provide at least a 100-fold speedup over a Kernel-Inducing Points (KIP) algorithm and can run on a single graphics processing unit. The disclosed Random Feature Approximation Distillation (RFAD) algorithm can perform competitively with other dataset condensation algorithms in accuracy over a range of large-scale datasets, both in kernel regression and finite-width network training. The disclosed techniques can be effective on tasks such as model interpretability and data privacy preservation.

IPC Classes  ?

  • G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
  • G06V 10/776 - Validation; Performance evaluation
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

8.

Methods And Apparatuses For Enhancing Scintillation With Optical Nanostructures For Scintillators, LEDs, And Laser Sources

      
Application Number 18286808
Status Pending
Filing Date 2022-04-12
First Publication Date 2024-06-27
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Joannopoulos, John
  • Johnson, Steven
  • Soljacic, Marin
  • Kooi, Steven
  • Beroz, Justin
  • Kaminer, Ido
  • Rivera, Nicholas
  • Yang, Yi
  • Roques-Carmes, Charles
  • Ghorashi, Ali
  • Lin, Zin
  • Romeo, Nicolas

Abstract

Methods and systems are disclosed that enhance the yield and speed of emission and control the spectral and angular emission of light emitted by materials under irradiation by high-energy particles through a process known as scintillation. In each case, a photonic structure (of nano- or micron-scale feature sizes) is integrated with a scintillating material, and the photonic structure enhances the yield or controls the spectrum of the material. Various embodiments of this technology and practical demonstrations are disclosed.

IPC Classes  ?

  • G01T 1/20 - Measuring radiation intensity with scintillation detectors
  • G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
  • G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays
  • G01N 23/2251 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes using incident electron beams, e.g. scanning electron microscopy [SEM]

9.

Variable Impedance Mechanical Interface

      
Application Number 18521259
Status Pending
Filing Date 2023-11-28
First Publication Date 2024-06-27
Owner Massachusetts Institute Technology (USA)
Inventor
  • Herr, Hugh M.
  • Marecki, Andrew
  • Sengeh, David M.

Abstract

A mechanical interface connecting a biological body segment, such as a limb, portion of a limb or other body segment, to a wearable device such as a prosthetic, orthotic or exoskeletal device, is fabricated by quantitatively mapping a characterized representation of the body segment to form a digital representation of the mechanical interface shape and mechanical interface impedance. The mechanical interface includes a continuous socket defining a contoured inside surface and a contoured outside surface, and includes a material having an intrinsic impedance that varies through the material, so that the intrinsic impedance varies along the contoured inside surface.

IPC Classes  ?

  • A61F 2/80 - Sockets, e.g. of suction type
  • A61F 2/50 - Prostheses not implantable in the body
  • A61F 2/78 - Means for protecting prostheses or for attaching them to the body, e.g. bandages, harnesses, straps, or stockings for the limb stump
  • G06F 30/00 - Computer-aided design [CAD]

10.

DC-DC CONVERTERS BASED ON PIEZOELECTRIC TRANSFORMERS

      
Application Number 18557172
Status Pending
Filing Date 2022-07-07
First Publication Date 2024-06-27
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Boles, Jessica
  • Ng, Elaine
  • Lang, Jeffrey H.
  • Perreault, David J.

Abstract

According to one aspect of the disclosure, a converter having a first port and a second port, the converter comprises: a piezoelectric transformer (PT) having a first port and a second port; one or more first switches configured to operate in accordance with a first switching sub-sequence to transfer energy from the first port of the converter to the first port of the PT, the first switching sub-sequence having at least six (6) stages; and one or more second switches configured to operate in accordance with a second switching sub-sequence to transfer energy from the second port of the PT to the second port of the converter.

IPC Classes  ?

  • H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
  • H02M 3/00 - Conversion of dc power input into dc power output

11.

SYSTEM AND METHOD FOR CALIBRATING ELECTROOCULOGRAPHY SIGNALS BASED ON HEAD MOVEMENT

      
Application Number 18557615
Status Pending
Filing Date 2022-06-30
First Publication Date 2024-06-27
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Rao, Hrishikesh
  • Palmer, Jeffrey S.
  • Nezvadovitz, Jason R.

Abstract

A method for calibrating eye information includes receiving eye state data measured during a calibration period, receiving head state data measured during the calibration period, calibrating the eye state data based on the head state data, and generating an eye angle measurement based on the calibrated eye state data. Calibrating the eye state data may include correlating the eye state data with the head state data during a period when a vestibulo-ocular reflex occurs. In some implementations, the eye state data may include eye movement data and the head state data may include head movement data. The calibrated eye state data is considered to have improved accuracy and therefore may be used as a more reliable basis for determining a variety of health conditions.

IPC Classes  ?

  • A61B 5/398 - Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
  • A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

12.

MEANS AND METHODS TO TARGET ENDOGENOUS CONDENSATES

      
Application Number EP2023086260
Publication Number 2024/133013
Status In Force
Filing Date 2023-12-18
Publication Date 2024-06-27
Owner
  • MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Germany)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Cissé, Ibrahim
  • Lee, Choongman

Abstract

The invention relates to a system for modifying a target biomolecule that is associated to an endogenous intracellular condensate formed by an intracellular protein comprising an Intrinsically Disordered Region (IDR), or to a system for modifying a chemical or physical property of an endogenous intracellular condensate. The system of the invention comprises as its minimal components an IDR polypeptide sequence tract comprising the Intrinsically Disordered Region of the intracellular protein, and an effector polypeptide domain capable of covalently modifying said target biomolecule.

IPC Classes  ?

  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

13.

METHODS OF DELIVERING THERAPEUTIC AGENTS, AND LIPID COMPOSITIONS

      
Application Number JP2023045247
Publication Number 2024/135604
Status In Force
Filing Date 2023-12-18
Publication Date 2024-06-27
Owner
  • FUJIFILM CORPORATION (Japan)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Toyonaga Sho
  • Anderson Daniel Griffith
  • Raimondo Theresa Marie
  • Shi Dennis Zheng

Abstract

1YY represents a single bond, an alkylene group having 1-14 carbon atoms, a substituted alkylene group having 1-14 carbon atoms, a heteroalkylene group having 1-14 carbon atoms, and a substituted heteroalkylene group having 1-14 carbon atoms. X represents a basic functional group.

IPC Classes  ?

  • A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
  • A61K 9/127 - Liposomes
  • A61K 9/51 - Nanocapsules
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
  • A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
  • A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

14.

IDENTIFICATION OF VARIABLE INFLUENZA RESIDUES AND USES THEREOF

      
Application Number 18187133
Status Pending
Filing Date 2023-03-21
First Publication Date 2024-06-27
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor Ricke, Darrell O.

Abstract

Provided herein are universal prophylactic compositions for preventing infection with influenza viruses by directing the immune response to highly conserved regions of the virus. Also provided are universal therapeutic compositions for treating influenza infection by targeting the highly conserved regions. Methods for using the prophylactic and therapeutic compositions are also provided.

IPC Classes  ?

15.

METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF

      
Application Number 18225531
Status Pending
Filing Date 2023-07-24
First Publication Date 2024-06-27
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Zhang, Feng
  • Habib, Naomi

Abstract

Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 9/22 - Ribonucleases
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
  • G16B 20/30 - Detection of binding sites or motifs
  • G16B 20/50 - Mutagenesis
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 30/10 - Sequence alignment; Homology search

16.

SYSTEMS AND METHODS FOR SELECTIVELY COATNG A SUBSTRATE USING SHADOWING FEATURES

      
Application Number 18382926
Status Pending
Filing Date 2023-10-23
First Publication Date 2024-06-27
Owner Massachusetts Institute of Technology (USA)
Inventor Ehrenberg, Isaac Mayer

Abstract

Systems and methods for producing electromagnetic devices are provided. The systems and methods allow for an electromagnetic device having both a substrate (e.g., polymer) and conductive material (e.g., metal) to be manufactured without using masks or other outside objects disposed over a surface (e.g., the substrate) onto which the conductive material is deposited. In one exemplary embodiment, the method includes performing additive manufacturing using a polymer to produce a device having a plurality of interconnected walls and a plurality of frequency selective surface elements, and then coating portions of the device with a conductive material. A plurality of shadowing features are formed as part of one or more of the walls to protect the frequency selective surface elements from being coated by the conductive material. Other methods, and a variety of systems that can result from the disclosed methods, are also provided.

IPC Classes  ?

  • C23C 14/20 - Metallic material, boron or silicon on organic substrates
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 80/00 - Products made by additive manufacturing
  • C23C 14/04 - Coating on selected surface areas, e.g. using masks
  • H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
  • H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
  • H05K 3/14 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using spraying techniques to apply the conductive material

17.

SEQUENCE-CONTROLLED POLYMER RANDOM ACCESS MEMORY STORAGE

      
Application Number 18589141
Status Pending
Filing Date 2024-02-27
First Publication Date 2024-06-27
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Bathe, Mark
  • Ratanalert, Sakul
  • Veneziano, Remi
  • Banal, James
  • Shepherd, Tyson

Abstract

Methods for controlled segregation of blocks of information encoded in the sequence of a biopolymer, such as nucleic acids and polypeptides, with rapid retrieval based on multiply addressing nanostructured data have been developed. In some embodiments, sequence controlled polymer memory objects include data-encoded biopolymers of any length or form encapsulated by natural or synthetic polymers and including one or more address tags. The sequence address labels are used to associate or select memory objects for sequencing read-out, enabling organization and access of distinct memory objects or subsets of memory objects using Boolean logic. In some embodiments, a memory object is a single-stranded nucleic acid scaffold strand encoding bit stream information that is folded into a nucleic acid nanostructure of arbitrary geometry, including one or more sequence address labels. Methods for controlled degradation of biopolymer-encoded blocks of information in the memory objects are also developed.

IPC Classes  ?

  • G06N 3/123 - DNA computing
  • B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
  • G06F 12/06 - Addressing a physical block of locations, e.g. base addressing, module addressing, address space extension, memory dedication
  • G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change

18.

PROVIDING TRAINED REINFORCEMENT LEARNING SYSTEMS

      
Application Number 18079123
Status Pending
Filing Date 2022-12-12
First Publication Date 2024-06-27
Owner
  • INTERNATIONAL BUSINESS MACHINES CORPORATION (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Nguyen, Lam Minh
  • Zhang, Wang
  • Das, Subhro
  • Megretski, Alexandre
  • Daniel, Luca

Abstract

Providing a trained reinforcement learning (RL) model by formulating a decision process problem for the RL model, defining at least one of a logarithmic loss function for the RL model and defining an initiation point for the RL model according to an optimized spectral norm of the RL model, training the system according to the logarithmic loss function or from the initiation point, and providing the trained RL model.

IPC Classes  ?

19.

KNITTED CELL SCAFFOLDS

      
Application Number US2023085584
Publication Number 2024/138085
Status In Force
Filing Date 2023-12-21
Publication Date 2024-06-27
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Gillmer, Steven, R.
  • Guo, Ming
  • Doran, Erin
  • Holtzman, Emily
  • Sandberg, Ariel
  • Bernasconi, Matthew

Abstract

Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.

IPC Classes  ?

  • A61F 2/02 - Prostheses implantable into the body
  • C12M 1/00 - Apparatus for enzymology or microbiology

20.

SYSTEMS AND METHODS FOR RAPID FLUSHING OF A MEMBRANE-BASED SYSTEM

      
Application Number 18556892
Status Pending
Filing Date 2022-05-02
First Publication Date 2024-06-20
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Wei, Quantum J.
  • Bouma, Andrew T.
  • Lienhard, John H.

Abstract

Systems and methods for rapid flushing of a membrane-based fluid filtration system are disclosed herein. During flushing, a membrane of the system can be decoupled from other portions of the system and brine can be flushed from the membrane separate from the other portions of the system. In some embodiments, the membrane can be connected to a pump to form a flushing loop that is separate from the flushing loops of the main system to flow the flushing fluid therethrough. The flushing fluid through the membrane can be optimized and set based on a flow rate of the membrane to prevent damaging the membrane while minimizing flush time of the membrane relative to the flush time of the system.

IPC Classes  ?

21.

NON-PLANAR METASURFACES AND RELATED FABRICATION METHODS

      
Application Number US2023084452
Publication Number 2024/130211
Status In Force
Filing Date 2023-12-15
Publication Date 2024-06-20
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Martin, Louis, Marie Philippe
  • Ranno, Luigi
  • Lin, Hung-I
  • Yang, Fan
  • Gu, Tian
  • Hu, Juejun

Abstract

Methods for transferring optically active features, such as meta-atoms and diffractive elements, formed on a planar surface to a non-planar surface with high precision are described. Optical devices having meta-atoms or other diffractive features located on non-planar and/or planar surfaces can be fabricated using the described methods. Related optical systems and components are described.

IPC Classes  ?

  • G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
  • G02B 3/00 - Simple or compound lenses
  • G02B 27/01 - Head-up displays

22.

METHOD OF DETECTING BACTERIAL/FUNGAL CONTAMINATION

      
Application Number 18288401
Status Pending
Filing Date 2022-04-18
First Publication Date 2024-06-20
Owner
  • Nanyang Technological University (Singapore)
  • Massachusetts Institute of Technology (USA)
  • National University of Singapore (Singapore)
Inventor
  • Huang, Jiayi
  • Rice, Scott Alan
  • Springs, Stacy L.
  • Lee, Yie Hou

Abstract

The present invention relates to a method of detecting the presence of a bacterial and/or fungal cell in a sample through detecting the presence of nicotinamidase activity or nicotinamidase, wherein the presence of nicotinamidase activity or nicotinamidase indicates the presence of a bacterial and/or fungal cell in the sample. The invention also relates to a method for monitoring bacterial and/or fungal cell contamination in a cell of tissue culture comprising detecting the presence of nicotinamidase activity or nicotinamidase in the cell or tissue culture.

IPC Classes  ?

  • C12Q 1/22 - Testing for sterility conditions
  • C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase

23.

SINGLE CELL ANALYSES

      
Application Number 18448121
Status Pending
Filing Date 2023-08-10
First Publication Date 2024-06-20
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Love, J. Christopher
  • Gierahn, Todd Michael
  • Shalek, Alexander K.
  • Wadsworth, Marc Havens
  • Hughes, Travis K.

Abstract

This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and case of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays.

IPC Classes  ?

  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • G03F 7/20 - Exposure; Apparatus therefor

24.

TECHNIQUES FOR MITIGATING OVERCURRENTS IN HIGH TEMPERATURE SUPERCONDUCTOR MAGNETS AND RELATED SYSTEMS AND METHODS

      
Application Number US2023083812
Publication Number 2024/129846
Status In Force
Filing Date 2023-12-13
Publication Date 2024-06-20
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Radovinsky, Alexey
  • Kelton, Nicholas, J.
  • Riccardo, Valeria
  • Sattarov, Akhdiyor, Israilovich

Abstract

Techniques are providing for mitigating overcurrents in superconducting magnets by adding a closed loop of superconductor to the magnet that acts as an electromagnetic shield. A time-varying external magnetic field may induce a current in the closed loop, thereby generating a magnetic field that opposes the external magnetic field, and reducing the amount of current induced by the external magnetic field in the primary current-carrying superconductor of the magnet. As a result, the effect of overcurrents can be reduced or removed.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01F 6/02 - Quenching; Protection arrangements during quenching

25.

FINE WIRE MUSCLE INTERFACES

      
Application Number US2023084147
Publication Number 2024/130043
Status In Force
Filing Date 2023-12-14
Publication Date 2024-06-20
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Taylor, Cameron, Roy
  • Herr, Hugh, M.

Abstract

Devices, systems, and methods described herein relate to a muscle interface and methods of use. The muscle interface may include an implant comprising a plurality of fine wires configured to be disposed in muscle tissue and to detect an electrical impedance at the muscle tissue; and a processor configured to determine a state of the muscle tissue based on the detected electrical impedance.

IPC Classes  ?

  • A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof

26.

NOVEL CHIMERIC ANTIGEN RECEPTORS AND LIBRARIES

      
Application Number 18505606
Status Pending
Filing Date 2023-11-09
First Publication Date 2024-06-13
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Birnbaum, Michael
  • Kyung, Taeyoon

Abstract

Provided herein are chimeric antigen receptor (CAR) viral libraries and methods of making the same. In some embodiments, the CAR comprises an intracellular domain (ICD) with at least one immune activation signaling domain, one co-stimulatory domain, and one or more inhibitory signaling domain or signaling domain from non-T cell lineages. In some embodiments, the signaling domains of the ICD are joined by distinct linkers of 10 amino acids. In some embodiments, the CARs contain a 18-nucleotide barcode in the 3′ untranslated region. Also provided herein, are CAR cell libraries and methods of making the same.

IPC Classes  ?

  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

27.

Bearingless Split Teeth Flux Reversal Motor

      
Application Number 18530495
Status Pending
Filing Date 2023-12-06
First Publication Date 2024-06-13
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Kant, Krishan
  • Trumper, David L.

Abstract

A bearingless split tooth flux-reversal motor (FRM) for use with a pump, such as a centrifugal blood pump. In some embodiments, the motor has a magnet-free rotor and a magnetic configuration wherein the force generation is independent of the rotor angle, allowing for simple radial force generation using stator-fixed currents. The motor torque can be generated using commutated two-phase currents.

IPC Classes  ?

  • H02K 21/40 - Synchronous motors having permanent magnets; Synchronous generators having permanent magnets with rotating flux distributors, and armatures and magnets both stationary with flux distributors rotating around the magnets and within the armatures
  • A61M 60/109 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems
  • A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
  • A61M 60/422 - Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
  • F04D 7/00 - Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts
  • F04D 13/06 - Units comprising pumps and their driving means the pump being electrically driven
  • H02K 1/17 - Stator cores with permanent magnets
  • H02K 1/24 - Rotor cores with salient poles

28.

ESTIMATING CONTRACTILE RESERVE USING A MECHANICAL CIRCULATORY SUPPORT DEVICE

      
Application Number 18533443
Status Pending
Filing Date 2023-12-08
First Publication Date 2024-06-13
Owner
  • Abiomed, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Curran, Jerald
  • Keller, Steven
  • Edelman, Elazer
  • El Katerji, Ahmad

Abstract

Methods and apparatus for determining a contractile reserve of a heart of a patient are provided. The method includes controlling a heart pump to operate at a first speed, determining based on a motor current signal received from a motor when the heart pump is operating at the first speed, a first value for a cardiac contractility metric, controlling the heart pump to operate at a second speed, determining based, at least in part, on the motor current signal received from the motor when the heart pump is operating at the second speed, a second value for the cardiac contractility metric, determining a contractile reserve metric based, at least in part, on the first value and the second value of the cardiac contractility metric, and outputting an indication of the contractile reserve metric on a user interface associated with the heart pump.

IPC Classes  ?

  • A61M 60/523 - Regulation using real-time patient data using blood flow data, e.g. from blood flow transducers
  • A61M 60/13 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
  • A61M 60/17 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps
  • A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
  • A61M 60/531 - Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
  • A61M 60/585 - User interfaces
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

29.

EVOLVING RANDOM HETEROPOLYMERS TOWARDS CATALYTICALLY ACTIVE MATERIALS

      
Application Number US2023076277
Publication Number 2024/123469
Status In Force
Filing Date 2023-10-06
Publication Date 2024-06-13
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Alexander-Katz, Alfredo
  • Hilburg, Shayna
  • Xu, Ting
  • Yu, Hao
  • Eres, Stefan Marco
  • Kang, Philjun

Abstract

The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.

IPC Classes  ?

  • C08F 4/02 - Carriers therefor
  • C08F 220/06 - Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof

30.

SYSTEMS AND METHODS FOR ROUTING SINGLE PHOTONS FROM A TRAPPED ION USING A PHOTONIC INTEGRATED CIRCUIT

      
Application Number US2023082346
Publication Number 2024/123697
Status In Force
Filing Date 2023-12-04
Publication Date 2024-06-13
Owner
  • UNIVERSITY OF MARYLAND, COLLEGE PARK (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, ARMY RESEARCH LABORATORY (USA)
Inventor
  • Saha, Uday
  • Waks, Edo
  • Siverns, James D.
  • Hannegan, John
  • Prabhu, Mihika
  • Englund, Dirk
  • Quraishi, Qudsia

Abstract

A system includes a quantum source and an optical device coupled to the quantum source. The quantum source is configured to emit an entangled photon. The optical device is configured to route the entangled photon to one or more outputs. In some aspects, the optical device can include a photonic integrated circuit (PIC). Advantageously the system can provide a routing scheme to route (e.g., passively, actively, dynamically, or a combination thereof) entangled photons from one or more quantum sources (e.g., trapped ion, single-photon source, quantum emitter, etc.) between different nodes, a quantum frequency conversion scheme to match near-infrared photons (750 nm to 1260 nm) and/or telecommunication photons (1260 nm to 1675 nm) entangled with photons from one or more quantum sources to an operating wavelength of the optical device (e.g., PIC), programmable routing and entanglement distribution, and scalable long-distance quantum networks.

IPC Classes  ?

  • H04B 10/70 - Photonic quantum communication
  • B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
  • G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

31.

ELECTROCHEMICAL SYSTEMS AND METHODS FOR RECYCLING LITHIUM-ION BATTERIES

      
Application Number US2023082389
Publication Number 2024/123713
Status In Force
Filing Date 2023-12-04
Publication Date 2024-06-13
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Shao-Horn, Yang
  • Huang, Botao
  • Tappan, Bryce

Abstract

Disclosed herein are systems and methods for electrochemical recycling of lithium-ion batteries and components thereof. For example, in some embodiments, an electrochemical system is provided for the recovery of nickel, manganese, copper, lithium, and/or cobalt. In some embodiments, the system comprises one or more electrochemical cells, wherein each electrochemical cell comprises a working electrode and a counter electrode, the working electrode and counter electrode separated by a separator. In some embodiments, the systems described herein are configured for the simultaneous recovery of two or more metal (ions) for a given electrochemical cell. For example, in some embodiments, during operation of an electrochemical cell as described herein, cobalt and/or nickel may be deposited on a (working) electrode while manganese is deposited on a (counter) electrode. The systems and methods described herein may be particularly advantageous for the recovery of raw materials from spent lithium-ion batteries.

IPC Classes  ?

  • C25C 1/02 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of light metals
  • C22B 26/12 - Obtaining lithium

32.

COMPOSITIONS AND METHODS FOR MODULATING NEURONAL EXCITABILITY

      
Application Number US2023082553
Publication Number 2024/123797
Status In Force
Filing Date 2023-12-05
Publication Date 2024-06-13
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Liu, Jia
  • Wang, Xiao

Abstract

The invention features compositions and methods for treating diseases or disorders associated with undesirable neuronal excitability (e.g., neurodegenerative disease, such as Parkinson's disease or Huntington's disease; or chronic pain, or epilepsy). The method comprises administering to a neuronal cell of the subject a vector comprising a mini Singlet Oxygen Generator (miniSOG) in the presence of monomers of 3,3'-diaminobenzidine or aniline and N phenyl p-phenylenediamine and irradiating at least a portion of the neuronal cell to induce polymerization of poly(3,3'-diaminobenzidine) or polyaniline.

IPC Classes  ?

  • A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
  • A61K 38/45 - Transferases (2)
  • A61P 25/00 - Drugs for disorders of the nervous system
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 15/864 - Parvoviral vectors

33.

Methods And Apparatus To Generate Macroscopic Fock And Other Sub-Poissonian States Of Radiation

      
Application Number 18286790
Status Pending
Filing Date 2022-04-12
First Publication Date 2024-06-13
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Soljacic, Marin
  • Rivera, Nicholas
  • Sloan, Jamison
  • Salamin, Yannick

Abstract

A principle which enables the generation of macroscopic Fock and sub-Poissonian states is disclosed. Generic components of the system include: an electromagnetic structure (possessing one or more electromagnetic resonances), a nonlinear electromagnetic element (such as a nonlinear crystal near or inside the structure), and a source of light. In one embodiment, stimulated gain is used to create large numbers of photons in a cavity, but with very low photon number noise (uncertainty) in the cavity, and thus acts as a Fock laser. This Fock laser is capable of producing these states due to a very sharp intensity-dependent gain (or loss) that selects a particular photon number. The disclosed system and method are robust against both atomic and optical decoherence. Various examples of the new Fock laser design are also described.

IPC Classes  ?

34.

TYPE VI CRISPR ORTHOLOGS AND SYSTEMS

      
Application Number 18334074
Status Pending
Filing Date 2023-06-13
First Publication Date 2024-06-13
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • President and Fellows of Harvard College (USA)
Inventor
  • Zhang, Feng
  • Abudayyeh, Omar O.
  • Gootenberg, Jonathan
  • Lander, Eric S.

Abstract

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

35.

POSITION SENSOR FOR BEARINGLESS SLICE MOTORS

      
Application Number 18532118
Status Pending
Filing Date 2023-12-07
First Publication Date 2024-06-13
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Kant, Krishan
  • Trumper, David L.

Abstract

A position sensor with six degrees of freedom (DoF) measurement capability may be used for position sensing of the rotor in a bearingless slice motor to enable active control. The sensor is designed to fit entirely under the rotor and operates by accessing the rotor bottom surface only, enabling packaging of the pump on the top of the rotor. The sensor has two parts; both operate using eddy currents. One of these parts measures the two radial DoF of the rotor. The other part measures the axial, angular rotation and tip/tilt DoF. The sensor utilizes a conductive target fixed to the underside of the rotor. The design and fabrication of the sensor along with the signal processing methods are described.

IPC Classes  ?

  • G01D 5/20 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying inductance, e.g. by a movable armature
  • G01B 7/30 - Measuring arrangements characterised by the use of electric or magnetic techniques for testing the alignment of axes

36.

HETEROGENOUS PHOTONIC INTEGRATION

      
Application Number US2023083110
Publication Number 2024/124125
Status In Force
Filing Date 2023-12-08
Publication Date 2024-06-13
Owner MASSACHUSETTS INTITUTE OF TECHNOLOGY (USA)
Inventor
  • Ranno, Luigi
  • Sia, Jia Xu, Brian
  • Hu, Juejun
  • Ross, Caroline
  • Vitale, Steven
  • Gu, Tian
  • Du, Qingyang
  • Popescu, Cosmin-Constantin
  • Hayashi, Kensuke
  • Dao, Khoi, Phuong

Abstract

Photonics has benefited immensely from advanced silicon manufacturing. By leveraging mature complementary metal-oxide-semiconductor (CMOS) process nodes, unprecedented device uniformity and scalability have been achieved at low cost. However, some functionalities, such as optical memory, Pockels modulation, and magneto-optical activity, are challenging or impossible to provide with group-IV materials alone. Heterogeneous integration promises to expand the range of capabilities within silicon photonics. Unfortunately, existing heterogeneous integration protocols are incompatible with the active silicon processes offered at most photonic foundries. Here, we disclose a heterogeneous integration platform that enables wafer-scale, multi-material integration with active silicon-based photonics, with no change to the existing foundry process. Furthermore, this heterogeneous integration platform enables a class of high-performance devices, including: a grating coupler with peak coupling efficiency reaching 93%, an antenna with peak diffraction efficiency in excess of 97%, and a broadband adiabatic polarization rotator with conversion efficiency exceeding 99%.

IPC Classes  ?

  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
  • H01L 31/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof

37.

NOVEL CRISPR ENZYMES AND SYSTEMS

      
Application Number 18235760
Status Pending
Filing Date 2023-08-18
First Publication Date 2024-06-06
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • President and Fellows of Harvard College (USA)
  • Skolkovo Institute of Science and Technology (Russia)
  • The United States of America, as represented by the Secretary, Dept. of Health and Human Services (USA)
Inventor
  • Severinov, Konstantin
  • Zhang, Feng
  • Wolf, Yuri I.
  • Shmakov, Sergey
  • Semenova, Ekaterina
  • Minakhin, Leonid
  • Makarova, Kira S.
  • Koonin, Eugene
  • Konermann, Silvana
  • Joung, Julia
  • Gootenberg, Jonathan S.
  • Abudayyeh, Omar O.
  • Lander, Eric S.

Abstract

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

IPC Classes  ?

  • C12N 15/90 - Stable introduction of foreign DNA into chromosome
  • C12N 9/22 - Ribonucleases
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

38.

Data-efficient Photorealistic 3D Holography

      
Application Number 18284920
Status Pending
Filing Date 2022-03-25
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Matusik, Wojciech
  • Shi, Liang

Abstract

A number of techniques provide a data efficient and/or computation efficient computer-generated holography, examples of which may be implemented on low-power devices such as smartphones and virtual-reality/augmented-reality devices and provide high fidelity holographic images. The techniques include used of layered depth image representations and end-to-end training of neural network generation of double-phase hologram encoding.

IPC Classes  ?

  • G03H 1/08 - Synthesising holograms
  • G03H 1/04 - Processes or apparatus for producing holograms
  • G03H 1/22 - Processes or apparatus for obtaining an optical image from holograms
  • G03H 1/26 - Processes or apparatus specially adapted to produce multiple holograms or to obtain images from them, e.g. multicolour technique

39.

MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS

      
Application Number 18400533
Status Pending
Filing Date 2023-12-29
First Publication Date 2024-06-06
Owner
  • Massachusetts Institute ofTechnology (USA)
  • Tokitae LLC (USA)
Inventor
  • Jaklenec, Ana
  • Gates, William
  • Welkhoff, Philip A.
  • Nikolic, Boris
  • Wood, Jr., Lowell L.
  • Langer, Robert S.
  • Nguyen, Thanh Duc
  • Tzeng, Stephany Yi
  • Norman, James J.
  • Mchugh, Kevin

Abstract

Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

IPC Classes  ?

  • A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 39/12 - Viral antigens

40.

COMPOSITIONS AND METHODS FOR MOLECULAR MEMORY STORAGE AND RETRIEVAL

      
Application Number 18439487
Status Pending
Filing Date 2024-02-12
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor Shepherd, Tyson Robert

Abstract

Compositions and methods for the storage, organization, access, and retrieval of information encoded by sequence controlled polymers such as data storage nucleic acids are provided. In some embodiments, organization, storage, and/or selective retrieval of the data is facilitated by hybridization of barcode sequence of the sequence controlled polymer to the reverse complementary sequence of an oligonucleotide. The plurality of oligonucleotides can be arrayed using a known organization scheme, and selectively capture and localize the corresponding sequence controlled polymer. In some embodiments, the compositions and methods utilize recombinant bacteriophage, typically featuring a minigenome having a bacteriophage origin of replication and packaging signal separated from a data storage sequence by barcodes.

IPC Classes  ?

  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]

41.

RECOVERY AND RECYCLING OF BYPRODUCTS OF ACTIVATED ALUMINUM

      
Application Number 18441342
Status Pending
Filing Date 2024-02-14
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Kelley, Jude
  • Morgan, Eric
  • Kuns, Roderick Russell

Abstract

Methods, systems, and compositions related to the recycling and/or recovery of activating materials from activated aluminum are disclosed. In one embodiment, an aqueous solution's composition may be controlled to maintain aluminum ions dissolved in solution during reaction of an activated aluminum. In another embodiment, aluminum hydroxide containing the activating materials may be dissolved into an aqueous solution to isolate the activating materials.

IPC Classes  ?

  • B01J 38/68 - Liquid treating or treating in liquid phase, e.g. dissolved or suspended including substantial dissolution or chemical precipitation of a catalyst component in the ultimate reconstitution of the catalyst
  • B01J 23/08 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of gallium, indium or thallium
  • B01J 23/94 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides of the iron group metals or copper
  • B01J 38/64 - Liquid treating or treating in liquid phase, e.g. dissolved or suspended using salts

42.

Generation And Synchronization Of Pulse-Width Modulated (PWM) Waveforms For Radio-Frequency (RF) Applications

      
Application Number 18443682
Status Pending
Filing Date 2024-02-16
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Jurkov, Alexander Sergeev
  • Perreault, David J.

Abstract

Described are concepts, systems, circuits and techniques directed toward methods and apparatus for generating one or more pulse width modulated (PWM) waveforms with the ability to dynamically control pulse width and phase with respect to a reference signal.

IPC Classes  ?

  • H03F 1/02 - Modifications of amplifiers to raise the efficiency, e.g. gliding Class A stages, use of an auxiliary oscillation
  • H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
  • H03F 3/19 - High-frequency amplifiers, e.g. radio frequency amplifiers with semiconductor devices only
  • H03F 3/193 - High-frequency amplifiers, e.g. radio frequency amplifiers with semiconductor devices only with field-effect devices
  • H03F 3/21 - Power amplifiers, e.g. Class B amplifiers, Class C amplifiers with semiconductor devices only
  • H03F 3/217 - Class D power amplifiers; Switching amplifiers
  • H03F 3/24 - Power amplifiers, e.g. Class B amplifiers, Class C amplifiers of transmitter output stages
  • H03H 7/38 - Impedance-matching networks
  • H03K 7/08 - Duration or width modulation

43.

GREEN SYNTHESIS OF AMINO ACID BASED POLY(ESTER UREA)S

      
Application Number 18515948
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Olsen, Bradley David
  • Fransen, Katharina

Abstract

Disclosed are methods of synthesizing poly(ester urea)s.

IPC Classes  ?

44.

SURFACES FOR CONTROLLED CELL ADHESION AND RELATED METHODS

      
Application Number US2023081432
Publication Number 2024/118657
Status In Force
Filing Date 2023-11-28
Publication Date 2024-06-06
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE BROAD INSTITUTE, INC. (USA)
Inventor
  • Varanasi, Kripa, K.
  • Mccue, Caroline, Taylor
  • Atari, Adel

Abstract

According to some embodiments, the cell culture system allows for the passage of cells in high-throughput cell culture applications. Unlike enzymatic detachment processes, the cell culture system, in some embodiments, limits any imparted damage onto the cell. Additionally, the lack of reliance on enzymes for cell detachments (e.g. trypsin) reduces and/or prevents the accrual of genetic mutations that can occur during enzymatic detachment processes. The cell culture system, in some embodiments, is capable of passaging and/or detaching cells at rates convenient for high throughput cell culturing and/or automated cell culturing regimes. Advantageously, the cell culture system, in certain embodiments, provides sufficient adhesion to promote cell growth and proliferation, but is capable of reducing the adhesion between the cell and the surface upon application of the electric field.

IPC Classes  ?

  • C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions

45.

DETECTION OF OLIGONUCLEOTIDES USING ANCHORED SINGLE-WALLED CARBON NANOTUBE CORONA PHASE

      
Application Number US2023081973
Publication Number 2024/119009
Status In Force
Filing Date 2023-11-30
Publication Date 2024-06-06
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Strano, Michael S.
  • Cui, Jianqiao
  • Gong, Xun
  • Jin, Xiaojia
  • Yang, Sungyun
  • Cho, Sooyeon

Abstract

The present invention provides a system and method for detecting an analyte in a sample comprising semiconducting single-walled carbon nanotubes (SWCNTs) and surface- adsorbed nucleic acids, wherein the surface-adsorbed nucleic acids comprise a complementary region and at least one anchor, wherein the complementary region comprises a nucleic acid sequence that is complementary' to and/or hybridizes to a target region of the analyte, and the at least one anchor comprises a nucleic acid sequence that is not complementary' to the target region of the analyte.

IPC Classes  ?

  • B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

46.

COMPOSITIONS FOR DETECTION OF FLUOROCARBONS AND RELATED ARTICLES, SYSTEMS, AND METHODS

      
Application Number US2023082090
Publication Number 2024/119082
Status In Force
Filing Date 2023-12-01
Publication Date 2024-06-06
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Swager, Timothy Manning
  • Concellon, Alberto

Abstract

Compositions, articles, systems, and methods for detection of fluorocarbons are generally described. In certain embodiments, for example, a sensing material that comprises a coupled-multichromophore is described. The coupled-multichromophore may be capable of energy transport and/or diffusion between individual sites of the coupled-multichromophore. In certain embodiments, for example, the coupled-multichromophore comprises individual sites that arc linked through delocalized orbitals such that the coupled-multichromophore is capable of energy transport and/or diffusion through each individual site of the coupled-multichromophore. The sensing material comprising the coupled-multichromophore may be configured to detect the presence of an analyte, such as a fluoroalkyl species (e.g., a per- and/or polyfluoroalkyl substance). For example, in some embodiments, the coupled-multichromophore comprises at least one chromophore that displays a change in electromagnetic radiation (e.g., light) emission in response to a presence of the analyte. The change in electromagnetic radiation emission may be detected to determine the presence of the analyte.

IPC Classes  ?

  • G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
  • C09B 69/10 - Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
  • G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
  • G01N 33/18 - Water

47.

CLEAVABLE COMONOMER STRATEGY FOR ACCELERATING REMOVAL OF GEL NAIL POLISH

      
Application Number US2023082177
Publication Number 2024/119140
Status In Force
Filing Date 2023-12-01
Publication Date 2024-06-06
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Johnson, Jeremiah A.
  • Cardoso Da Costa, Leticia C.
  • Prince, Elisabeth

Abstract

The present invention provides polymer compositions for use in cosmetic nail polish compositions. More particularly, the present disclosure relates to the introduction of cleavable conomoner additives into an existing polymer composition to produce a chemically deconstructable composition. Methods and compositions for removing the nail polish composition are also disclosed.

IPC Classes  ?

  • A61K 8/04 - Dispersions; Emulsions
  • A61K 8/18 - Cosmetics or similar toiletry preparations characterised by the composition
  • A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A45D 29/00 - Manicuring or pedicuring implements
  • A61Q 3/02 - Nail coatings

48.

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

      
Application Number 18109550
Status Pending
Filing Date 2023-02-14
First Publication Date 2024-06-06
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
Inventor Zhang, Feng

Abstract

The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

IPC Classes  ?

  • C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
  • C12N 9/22 - Ribonucleases
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
  • G16B 20/30 - Detection of binding sites or motifs
  • G16B 20/50 - Mutagenesis
  • G16B 30/10 - Sequence alignment; Homology search

49.

METHODS AND COMPOSITIONS FOR DETECTION OF TUMOR DNA

      
Application Number 18285103
Status Pending
Filing Date 2022-03-30
First Publication Date 2024-06-06
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • The General Hospital Corporation (USA)
Inventor
  • Adalsteinsson, Viktor A.
  • Hacohen, Nir
  • Bhatia, Sangeeta N.
  • Patel, Sahil
  • An, Zhenyi

Abstract

This disclosure provides a method and compositions for substantially increasing the concentration of DNA in macrophages of a patient. By administering to a patient one or more agents which prevent the activity of deoxyribonucleases within lysosomes of macrophages, degradation of DNA phagocytosed by macrophages is temporarily blocked, permitting its accumulation. This strategy has the potential to enhance the detection of genetic biomarkers from cells typically phagocytosed by macrophages, such as tumor cells, and thus has applications for early or residual detection of cancer.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • A61K 31/4706 - 4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

50.

ALUMINUM-CHALCOGEN BATTERIES WITH ALKALI HALIDE MOLTEN SALT ELECTROLYTES

      
Application Number 18556497
Status Pending
Filing Date 2022-03-11
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Sadoway, Donald R.
  • Pang, Quanquan
  • Meng, Jiashen
  • Zhao, Ji

Abstract

A rechargeable, self-heating aluminum-chalcogen battery is provided, with an aluminum or aluminum alloy negative electrode, a positive electrode of elemental chalcogen, and a mixture of chloride salts providing a molten salt electrolyte. The predominant chloride salt in the electrolyte is AlCh. Additional chloride salts are chosen from alkali metal chlorides. The cell operates at a modestly elevated temperatures, ranging from 90° C. to 250° C.

IPC Classes  ?

  • H01M 4/46 - Alloys based on magnesium or aluminium
  • H01M 4/02 - Electrodes composed of, or comprising, active material
  • H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
  • H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
  • H01M 10/653 - Means for temperature control structurally associated with the cells characterised by electrically insulating or thermally conductive materials

51.

RAPID FABRICATION OF SEMICONDUCTOR THIN FILMS

      
Application Number 18562679
Status Pending
Filing Date 2022-05-26
First Publication Date 2024-06-06
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Bulovic, Vladimir
  • Swartwout, Richard

Abstract

Semiconductor thin films and rapid methods of fabrication can include mixed cations created through recrystalization.

IPC Classes  ?

  • H10K 85/50 - Organic perovskites; Hybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
  • C07F 19/00 - Metal compounds according to more than one of main groups
  • C09D 11/033 - Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
  • C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
  • C09D 11/52 - Electrically conductive inks
  • H10K 30/10 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising heterojunctions between organic semiconductors and inorganic semiconductors
  • H10K 30/50 - Photovoltaic [PV] devices
  • H10K 71/15 - Deposition of organic active material using liquid deposition, e.g. spin coating characterised by the solvent used

52.

SOLUTION PROCESSABLE ULTRA-THIN SUBSTRATES AND RELATED TECHNIQUES

      
Application Number US2023081244
Publication Number 2024/118543
Status In Force
Filing Date 2023-11-28
Publication Date 2024-06-06
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Bulovic, Vladimir
  • Saravanapavanantham, Mayuran
  • Mwaura, Jeremiah

Abstract

Described are concepts, systems, methods, and machines for providing a device (e.g., electronic device) on a transferable, ultra-thin substrate. The described concepts, systems, methods, and machines may be used to produce an electronic device on a transferable, ultra-thin substrate using only solution-based (e.g., wet) processing techniques. The described concepts systems, methods, and machines may also be used to produce a releasable substrate for the electronic device having a certain desired characteristic. Structures including a device are also described. The structures may include the device, a releasable substrate, and a removable release liner carrier. Also described are systems, methods, and machines for removing a release liner carrier from a releasable substrate and device, for applying the releasable substrate and device to a permanent substrate, and for reusing the release liner carrier to produce another device.

IPC Classes  ?

  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
  • B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying

53.

LOW VOLTAGE INSULATION FOR HIGH-TEMPERATURE SUPERCONDUCTING MAGNETS

      
Application Number US2023081302
Publication Number 2024/118576
Status In Force
Filing Date 2023-11-28
Publication Date 2024-06-06
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Radovinsky, Alexey
  • Kuznetsov, Sergey
  • Kelton, Nicholas, J.
  • Labombard, Brian
  • Craighill, Christopher
  • Lammi, Christopher, J.
  • Sanabria, Charlie

Abstract

Described is an insulative layer for use in systems utilizing a high temperature superconductor (HTS). The insulative layer comprises a first layer of an insulative material, a second layer of an insulative material and a third layer of an electrically conductive material disposed the first and second layers. The electrically insulating material of the first layer and the electrically insulating material of the second layer are both resistant to grinding forces. The third layer is provided from a material having a resistance to oxidative degradation, weather, and radiation, as well as resistance to abrasive and fictional wear at cryogenic temperatures. In one application, the insulative layer may be disposed at an interface between a toroidal field (TF) coil and a central solenoid (CS) of a high temperature superconducting magnet.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01F 27/36 - Electric or magnetic shields or screens
  • G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
  • G21B 1/11 - Thermonuclear fusion reactors - Details

54.

HIGH-TEMPERATURE SUPERCONDUCTOR MAGNETS WITH QUENCH DAMAGE RESILIENCY

      
Application Number US2023081450
Publication Number 2024/118671
Status In Force
Filing Date 2023-11-28
Publication Date 2024-06-06
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • COMMONWEALTH FUSION SYSTEMS LLC (USA)
Inventor
  • Labombard, Brian
  • Uppalapati, Krishna, Kiran, Kumar
  • Sattarov, Akhdiyor, Israilovich

Abstract

Techniques are described for improving quench damage resiliency in non-insulated (NI) high temperature superconductor (HTS) magnets. The techniques may include tuning an amount of HTS tape within turns of a winding of an NI-HTS magnet to reduce variation in critical current across the winding, and/or may include adjusting the turn-to-turn resistance of the windings by adjusting turn-to-turn spacing between windings and thereby reduce variations in joule heating between turns during a quench.

IPC Classes  ?

  • H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
  • H01F 6/02 - Quenching; Protection arrangements during quenching
  • G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement

55.

Biosensors in Human Gut Organoids

      
Application Number 18432695
Status Pending
Filing Date 2024-02-05
First Publication Date 2024-05-30
Owner
  • The General Hospital Corporation (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Fasano, Alessio
  • Lu, Timothy K.
  • Senger, Stefania
  • Inda, Maria Eugenia

Abstract

Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

56.

Swellable and Structurally Homogenous Hydrogels and Methods of Use Thereof

      
Application Number 18523580
Status Pending
Filing Date 2023-11-29
First Publication Date 2024-05-30
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Gao, Ruixuan
  • Gao, Linyi
  • Yu, Chih-Chieh
  • Boyden, Edward Stuart

Abstract

The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

IPC Classes  ?

  • C08J 3/075 - Macromolecular gels
  • C08F 8/00 - Chemical modification by after-treatment
  • C08F 8/12 - Hydrolysis
  • C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
  • C08F 8/44 - Preparation of metal salts or ammonium salts
  • C08F 222/10 - Esters
  • C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
  • C08G 65/32 - Polymers modified by chemical after-treatment
  • C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
  • C12Q 1/6841 - In situ hybridisation
  • C12Q 1/6869 - Methods for sequencing
  • G01N 1/30 - Staining; Impregnating
  • G01N 33/545 - Synthetic resin
  • C08F 220/04 - Acids; Metals salts or ammonium salts thereof
  • C08F 220/30 - Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
  • C08F 220/34 - Esters containing nitrogen
  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 15/0205 - by optical means

57.

BUBBLE GAS HARVESTING AND/OR TRANSPORT METHODS AND ASSOCIATED SYSTEMS AND ARTICLES

      
Application Number 18529435
Status Pending
Filing Date 2023-12-05
First Publication Date 2024-05-30
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Varanasi, Kripa K.
  • Rapoport, Leonid

Abstract

Described herein are methods for transporting and/or harvesting gas from bubbles, as well as associated articles and systems. In some embodiments, transporting and/or harvesting the gas from the bubbles can reduce or prevent the amount of foam that is present within a system. According to certain embodiments, a conduit comprising a porous wall portion can be at least partially submerged into a foam and/or a bubble-containing liquid. The porous wall portion of the conduit can be configured and/or arranged, according to certain embodiments, such that the porous wall portion provides a fluidic pathway through which gas from the bubbles within the liquid may be channeled to a gaseous environment in the interior portion of the conduit. The gas may be transported, according to certain embodiments, along the interior portion of the conduit into an external gaseous environment and/or harvested from the interior portion of the conduit.

IPC Classes  ?

  • B01D 19/00 - Degasification of liquids
  • B01D 19/02 - Foam dispersion or prevention
  • C02F 1/20 - Treatment of water, waste water, or sewage by degassing, i.e. liberation of dissolved gases

58.

METHODS FOR TRANSFORMING SILICATE-CONTAINING MATERIALS INTO MATERIALS FOR CO2 REMOVAL AND OTHER APPLICATIONS

      
Application Number US2023026567
Publication Number 2024/112368
Status In Force
Filing Date 2023-06-29
Publication Date 2024-05-30
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventor
  • Surendranath, Yogesh
  • Toh, Wei Lun
  • Kanan, Matthew
  • Agarwal, Rishi Gupta
  • Charnay, Benjamin Peter
  • Chen, Yuxuan
  • Rabinowitz, Joshua Avraam

Abstract

Disclosed herein is a method of forming a precipitate, comprising: a. providing a salt solution; b. performing electrochemical reactions in the salt solution to produce a solution of lower pH and a solution of higher pH; c. providing a silicate-containing material containing Mg2+ and/or Ca2+ ions; d. treating the silicate-containing material with the solution of lower pH to dissolve at least a portion of the silicate-containing material and generate a second solution with higher pH; e. combining the solution generated in (d) with at least a portion of the solution with higher pH generated in (b) to form the precipitate and a second salt solution; and f. recycling the second salt solution generated in step (e) by adding (b).

59.

SYSTEMS AND METHODS FOR MUSCLE-TENDON CONTROL OF WEARABLE-ROBOTIC DEVICES

      
Application Number US2023080814
Publication Number 2024/112829
Status In Force
Filing Date 2023-11-21
Publication Date 2024-05-30
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Herr, Hugh, M.
  • Herrera-Arcos, Jesus, Guillermo
  • Nawrot, Michael, Thomas
  • Qiao, Junqing
  • Shallal, Christopher
  • Song, Hyungeun

Abstract

Devices, systems, and methods herein are generally directed to a robotic control system that comprises: a wearable robot comprising at least one actuated joint; at least one muscle-tendon interface configured to measure at least one physiological signal; a torque set point processor configured to receive the at least one physiological signal from the at least one muscle tendon interface and estimate a muscle-tendon state corresponding to a human motor intention and to compute at least one augmentation joint torque based on the muscle-tendon state; and a torque controller configured to apply the at least one augmentation joint torque to the at least one actuated joint of the wearable robot.

IPC Classes  ?

  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
  • A61F 2/50 - Prostheses not implantable in the body

60.

A RADIO SYSTEM USING A PHASE-RECONFIGURABLE REFLECTARRAY FOR ADAPTIVE BEAMFORMING

      
Application Number 18517727
Status Pending
Filing Date 2023-11-22
First Publication Date 2024-05-30
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Browne, David W.
  • Appadwedula, Swaroop
  • Chapman, Christian D.
  • Forsythe, Keith W.
  • Hatke, Gary F.
  • Guerriero, Benjamin R.
  • Moulder, William F.
  • Yazdani, Navid

Abstract

The disclosed system uses a less complex system of a single radio receiver-frontend with a phase-reconfigurable reflectarray and an antenna to form beams in directions of the desired arriving signals while forming nulls in directions of the arriving radio interference signals. This is done by configuring each reflector with an appropriate phase-shift state so that the amplification of the desired radio signals and the nulling of the undesired radio signals happen at the point all reflected radio signals combine at the antenna (before the receiver frontend). In comparison, a conventional digital receive array achieves beams and nulls by taking the sampled radio signal streams at the outputs of the receiver frontends, multiplies each sample stream by a digital weight to shift the stream's phase and/or amplitude and then combines the sample streams into one sample stream in which desired radio signals are amplified and undesired radio signals are attenuated.

IPC Classes  ?

  • H04B 7/04 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
  • H04B 7/0408 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas using two or more beams, i.e. beam diversity

61.

SYSTEMS AND METHODS FOR MANUFACTURING CURBSIDE-RECYCLABLE PRODUCTS FROM MONO-MATERIALS POLYETHYLENE FABRICS WITH POLYETHYLENE THREE-DIMENSIONALLY PRINTED FEATURES

      
Application Number 18523845
Status Pending
Filing Date 2023-11-29
First Publication Date 2024-05-30
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Boriskina, Svetlana V.
  • Korolovych, Volodymyr
  • Yan, Leslie
  • Xu, Duo

Abstract

A polyethylene (PE)-based fully-recyclable textile material and product formed by three-dimensionally printing PE structures onto a polyethylene textile is provided. The textile material can include one or more PE filaments being directly deposited onto a PE fabric via an FDM printing process to form a mono-material. The deposition of structures onto the PE fabric, which can form the substrate of the textile, can be used to enable changes to the mechanical properties of the fabric and/or create novel design aesthetics. Moreover, this material can be characterized by its ability to be thermally recycled, from which new PE-based products and materials may be manufactured. For example, the PE-based fully-recyclable textile material can be formed into a PE recyclate that can be melted and re-pelletized for formation of alternative PE-based fully recyclable textile materials. The PE-based fully recyclable textile material can be used in footwear and other wearable applications, as well as spacesuits, helmets, bulletproof vests, sweat-proof garments, racing suits, and so forth.

IPC Classes  ?

  • B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
  • B29B 17/04 - Disintegrating plastics
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
  • B33Y 70/00 - Materials specially adapted for additive manufacturing
  • B33Y 80/00 - Products made by additive manufacturing
  • D03D 1/00 - Woven fabrics designed to make specified articles
  • D03D 15/283 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads synthetic polymer-based, e.g. polyamide or polyester fibres
  • D04H 3/007 - Addition polymers
  • D04H 3/05 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments in another pattern, e.g. zig-zag, sinusoidal
  • D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
  • D06C 7/02 - Setting

62.

HIGHLY EFFICIENT, SALT REJECTING, WICK-FREE SOLAR EVAPORATION

      
Application Number US2023080523
Publication Number 2024/112662
Status In Force
Filing Date 2023-11-20
Publication Date 2024-05-30
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • SHANGHAI JIAO TONG UNIVERSITY (China)
Inventor
  • Wang, Evelyn, N.
  • Li, Xiangyu
  • Zhong, Yang
  • Zhang, Lenan
  • Leroy, Amy
  • Zhao, Lin
  • Xu, Zhenyuan

Abstract

A system for desalinating water, the system comprising: a confined water layer, wherein the water layer is separated from the solar absorber by an air layer; a floating insulation below the confined water layer, wherein the floating insulation comprises a multiplicity of macro channels; a balancing weight, wherein the balancing weight is attached to the floating insulation and reduces buoyancy of the floating insulation in the confined water layer; and a bulk water layer, wherein the macro channels connect the bulk water to the confined water layer.

IPC Classes  ?

  • C02F 1/14 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using solar energy
  • C02F 1/08 - Thin film evaporation
  • C02F 1/24 - Treatment of water, waste water, or sewage by flotation

63.

SELECTIVE MEMBRANES AND RELATED METHODS

      
Application Number US2023080744
Publication Number 2024/112793
Status In Force
Filing Date 2023-11-21
Publication Date 2024-05-30
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Karnik, Rohit N.
  • Field, Randall Perkins
  • Persad, Aaron
  • Cheng, Chi David
  • Kim, Lohyun

Abstract

Hydrogen selective membranes and related methods are generally described. In some embodiments, a hydrogen selective membrane may exhibit high permeance and selectivity in comparison to conventional polymer membranes, at low material costs. The membrane may also be thermally and chemically stable at high operational temperatures. In some embodiments, the membrane may include a layer of inorganic material (e.g., palladium) and a layer of atomically thin material (e.g., graphene) arranged on a porous substrate. The inorganic material may be arranged in a film-like or an isolated island-type architecture. In other embodiments, the inorganic material may be arranged within the pores of the porous substrate in an isolated plug- type fashion.

IPC Classes  ?

64.

FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS FOR SATURATING MUTAGENESIS OF NON-CODING ELEMENTS, COMPOSITIONS, METHODS, LIBRARIES AND APPLICATIONS THEREOF

      
Application Number 18317248
Status Pending
Filing Date 2023-05-15
First Publication Date 2024-05-23
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • Children's Medical Center Corporation (USA)
Inventor
  • Bauer, Daniel E.
  • Orkin, Stuart H.
  • Sanjana, Neville Espi
  • Shalem, Ophir
  • Wright, Jason
  • Zhang, Feng

Abstract

The application relates to a deep scanning mutagenesis library to interrogate phenotypic changes in a population of cells comprising a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within at least one continuous genomic region, wherein the guide RNAs target at least 100 genomic sequences upstream of a PAM sequence for every 1000 base pairs within the continuous genomic region and methods for their use.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

65.

MULTI-MATERIAL FIBERS AND METHODS OF MANUFACTURING THE SAME

      
Application Number 18425439
Status Pending
Filing Date 2024-01-29
First Publication Date 2024-05-23
Owner
  • Advanced Functional Fabrics of America, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Chung, Chia-Chun
  • Cox, Jason
  • Mccarthy, Kristina
  • Mulherin, Kristen
  • Nguyen, Jimmy
  • Rein, Michael
  • Bernasconi, Matthew
  • Cantley, Lauren
  • Parameswaran, Lalitha
  • Rickley, Michael
  • Stolyarov, Alexander
  • Deisenhaus, Joshua

Abstract

Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.

IPC Classes  ?

  • B29C 51/00 - Shaping by thermoforming, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
  • B23K 1/00 - Soldering, e.g. brazing, or unsoldering
  • B29C 51/12 - Shaping by thermoforming, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor of articles having inserts or reinforcements
  • B29D 11/00 - Producing optical elements, e.g. lenses or prisms
  • B29D 99/00 - Subject matter not provided for in other groups of this subclass
  • D01D 5/00 - Formation of filaments, threads, or the like

66.

A MICRO-OPTICAL STRUCTURE AND A METHOD FOR FORMING A MICRO-OPTICAL STRUCTURE

      
Application Number US2023080179
Publication Number 2024/108069
Status In Force
Filing Date 2023-11-16
Publication Date 2024-05-23
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Ranno, Luigi
  • Gu, Tian
  • Michel, Jurgen
  • Hu, Juejun
  • Bao, Shuyu
  • Lee, Kenneth Eng Kian
  • Zhao, Xueying
  • Niu, Jing

Abstract

A micro-optical structure (200) for a micro-scale light source (202) having an emitting surface for emitting light is described. The micro-optical structure (200) comprises a reflective portion (204) formed on the emitting surface of the micro-scale light source, where the reflective portion (204) is adapted to reflect light emitted from the micro-scale light source (202) out of the micro-optical structure (200). A method for forming a micro-optical structure (200) is also described.

IPC Classes  ?

67.

MATERIALS FOR EXTRACTING TOXINS FROM TOBACCO

      
Application Number 17981233
Status Pending
Filing Date 2022-11-04
First Publication Date 2024-05-23
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Swager, Timothy Manning
  • Lu, Ruqiang

Abstract

Compositions configured to interact with organic molecules, and related articles and methods, are generally described.

IPC Classes  ?

  • A24B 15/18 - Treatment of tobacco products or tobacco substitutes
  • A24B 15/28 - Treatment of tobacco products or tobacco substitutes by chemical substances
  • A24B 15/30 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

68.

PREPARATION OF TEMPLATES FOR METHYLATION ANALYSIS

      
Application Number 18500680
Status Pending
Filing Date 2023-11-02
First Publication Date 2024-05-23
Owner
  • ILLUMINA CAMBRIDGE LIMITED (United Kingdom)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Gormley, Niall Anthony
  • Gnirke, Andreas
  • Jaffe, David
  • Nusbaum, Harris

Abstract

The invention relates to a method of preparing and using a library of template polynucleotides suitable for use as templates in solid-phase nucleic acid amplification and sequencing reactions to determine the methylation status of the cytosine bases in the library. In particular, the invention relates to a method of preparing and analysing a library of template polynucleotides suitable for methylation analysis.

IPC Classes  ?

  • C12Q 1/6855 - Ligating adaptors
  • C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

69.

Pixel Scale Fabry Perot Filter Array for Chemical Agent Vapor Detection

      
Application Number 18159385
Status Pending
Filing Date 2023-01-25
First Publication Date 2024-05-23
Owner Massachusetts Institute of Technology (USA)
Inventor Lawrence, William

Abstract

Fabry-Pérot filters having different cavity thicknesses are formed in arrays on a substrate for spectral sensing. The filter array can be coupled to a detector array to make a compact, low size, weight and power spectral sensor that detects spectral information in a scene viewed by the detector array. The spectral sensor can be used in a compact spectrometer to detect the presence of harmful chemical vapors.

IPC Classes  ?

  • G01J 3/28 - Investigating the spectrum
  • G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
  • G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor

70.

LOW LOSS BROADBAND QUANTUM LIMITED FLOQUET-MODE AMPLIFIER

      
Application Number US2023035080
Publication Number 2024/107294
Status In Force
Filing Date 2023-10-13
Publication Date 2024-05-23
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • O'Brien, Kevin
  • Peng, Kaidong

Abstract

A Floquet mode traveling wave parametric amplifier (TWPA) is disclosed. The Floquet mode TWPA comprises a plurality of stages, where each stage is made up of a nonlinear element and a shunt capacitor. The nonlinear elements may be Josephson junctions, or a combination of series and/or parallel Josephson junctions. The Floquet mode TWPA is designed such that the critical current of the nonlinear elements in each stage is not constant. In some embodiments, the ratio of the largest critical current to the smallest critical current in the Floquet mode TWPA is at least 2:1. In some embodiments, the nonlinear elements with the largest critical current are disposed at or near the input or output of the amplifier. In this way, reflections and backward amplification may be minimized. Further, the TWPA is formed using planar capacitors on a high resistivity substrate, or using low loss parallel plate capacitors.

IPC Classes  ?

  • H03F 19/00 - Amplifiers using superconductivity effects
  • G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
  • H03F 7/00 - Parametric amplifiers
  • H01B 12/02 - Superconductive or hyperconductive conductors, cables or transmission lines characterised by their form

71.

HETEROGENEOUS CATALYSTS

      
Application Number US2023036096
Publication Number 2024/107323
Status In Force
Filing Date 2023-10-27
Publication Date 2024-05-23
Owner
  • DOW GLOBAL TECHNOLOGIES LLC (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Bedard, Anne-Catherine
  • Hosseininasab, Valiallah
  • Dinca, Mircea
  • Payne, Michael Tyrel
  • Bour, James

Abstract

Embodiments of the present disclosure are directed towards a heterogenous catalyst composition of formed from using a crystalline porous metal-organic framework (MOF) which reacts in an inverse electron-demand Diels-Alder reaction with a phosphorous ligand to produce a heterogeneous catalyst precursor. The heterogeneous catalyst precursor then reacts with a Group VIII transition metal catalyst precursor compound to form the heterogeneous catalyst composition that can be used for the hydroformylation of olefins, among other reactions.

IPC Classes  ?

  • B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
  • B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
  • B01J 31/24 - Phosphines
  • C07C 47/02 - Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen

72.

CONTROLLED LIPID SELF-ASSEMBLY FOR SCALABLE MANUFACTURING OF NEXT-GENERATION IMMUNE STIMULATING COMPLEXES

      
Application Number US2023074206
Publication Number 2024/107474
Status In Force
Filing Date 2023-09-14
Publication Date 2024-05-23
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Irvine, Darrell
  • Hammond, Paula
  • Pires, Ivan Susin

Abstract

Methods of controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes (ISCOMs) are described. The methods involve mixing one or more saponins, one or more lipids, one or more sterols, one or more additional adjuvants (e.g., TLR4 agonist), and optionally one or more antigens in the presence of a detergent. Typically, the mixing step is followed by an incubation step, a dilution and/or concentration step, and/or a filtration or dialysis step for removing detergent. Preferably, methods involve a tangential flow filtration (TFF) process suitable for scalable synthesis and Good Manufacturing Practice (GMP) production of highly homogeneous clinical-grade ISCOM-based adjuvants.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • A61K 9/127 - Liposomes
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/19 - Particulate form, e.g. powders lyophilised
  • A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
  • B82Y 40/00 - Manufacture or treatment of nanostructures
  • A61K 9/00 - Medicinal preparations characterised by special physical form

73.

COMPOSITIONS AND METHODS FOR ANTIBODY MEDIATED DELIVERY OF ANTIGEN TO B CELL FOLLICLES

      
Application Number US2023074434
Publication Number 2024/107477
Status In Force
Filing Date 2023-09-18
Publication Date 2024-05-23
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Aung, Aereas
  • Irvine, Darrell J.

Abstract

Compositions and methods for increasing delivery of antigen to B cell follicles are provided. The compositions typically include an antigen and a CD35, FDC-M1, FDC-M2, fixative-resistant antigen, FDCSP, CD21, C4, MFG-E8, CD21, or FC receptor binding moiety that are linked or otherwise conjugated to form a binding moiety-antigen molecule or conjugate. Typically, the antigen and binding moieties are polypeptides and in preferred embodiments, the binding moiety-antigen is a fusion protein. The binding moiety is preferably an antibody that specifically binds to CD35, preferably an scFv. The antigen can be derived from, for example, a virus, bacterium, parasite, plant, protozoan, fungus, tissue or transformed cell such as a cancer. Pharmaceutical compositions including the binding moiety-antigen or a nucleic acid encoding the same, and optionally an adjuvant are also provided, as are methods of using the compositions for increasing an immune response in a subject in need thereof.

IPC Classes  ?

74.

THERAPEUTIC EXPLOITATION OF STING CHANNEL ACTIVITY

      
Application Number US2023079800
Publication Number 2024/107827
Status In Force
Filing Date 2023-11-15
Publication Date 2024-05-23
Owner
  • THE BROAD INSTITUTE, INC. (USA)
  • THE GENERAL HOSPITAL CORPORATION (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Hacohen, Nir
  • Liu, Bingxu
  • Carlson, Rebecca
  • Gentili, Matteo

Abstract

In certain aspects, provided herein are mutant stimulator of interferon genes (STING) polypeptides, compositions thereof and methods of using the same, wherein the mutation is within the dimerization interface of the STING, and wherein the mutation reduces the ability of the mutant STING polypeptide to mediate protein leakage across a membrane compared to a wild-type STING polypeptide.

IPC Classes  ?

  • A61K 38/00 - Medicinal preparations containing peptides
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals

75.

COMPOSITIONS AND METHODS FOR AMELIORATING ANTERODORSAL THALAMUS HYPEREXCITABILITY

      
Application Number 18394297
Status Pending
Filing Date 2023-12-22
First Publication Date 2024-05-16
Owner
  • The Broad Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Feng, Guoping
  • Roy, Dheeraj
  • Zhang, Ying

Abstract

The disclosure features compositions and methods for ameliorating cognitive impairments associated with neuropsychiatric disorders, particularly those associated with anterodorsal (AD) thalamus hyperexcitability in the brain of a subject. Various embodiments of the disclosure provide for personalized and targeted therapeutic approaches for screening, diagnosing, preventing, and treating cognitive impairments and neuropsychiatric disorders.

IPC Classes  ?

  • C12N 15/86 - Viral vectors
  • A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • A61P 25/00 - Drugs for disorders of the nervous system
  • C07K 14/72 - Receptors; Cell surface antigens; Cell surface determinants for hormones

76.

ELECTRICALLY CONDUCTIVE FIREBRICK SYSTEM

      
Application Number 18526880
Status Pending
Filing Date 2023-12-01
First Publication Date 2024-05-16
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Forsberg, Charles
  • Stack, Daniel C.

Abstract

A thermal energy storage system includes a firebrick checkerwork and an electrode. The firebrick checkerwork includes one or more conductive firebrick layers, each including a plurality of electrically conductive doped metal oxide firebricks with one or more airflow vents. The electrode includes one or more electrode firebrick layers, each layer including a plurality of electrode firebricks. The firebrick checkerwork is heated due to application of electrical power to the electrode. Air flowing through the firebrick checkerwork may then be heated for use in heat-related applications (e.g., an industrial application, commercial application, residential application, transportation application, etc.) some of which may relate to electricity production or in other applications which may relate to other purposes that require heat that are unrelated to electricity production.

IPC Classes  ?

77.

METHODS AND COMPOSITIONS FOR PREDICTING AND PREVENTING RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA

      
Application Number 18541680
Status Pending
Filing Date 2023-12-15
First Publication Date 2024-05-16
Owner
  • Massachusetts Institute of Technology (USA)
  • Dana-Farber Cancer Institute, Inc. (USA)
Inventor
  • Shalek, Alexander K.
  • Winter, Peter
  • Weinstock, David
  • Murakami, Mark
  • Manalis, Scott
  • Navia, Andrew
  • Galvez-Reyes, Jennyfer

Abstract

Described in exemplary embodiments herein are methods, compositions, and kits for diagnosing, prognosing, monitoring, treating and/or preventing a hemopoietic malignancy and/or relapse thereof in a subject. In some embodiments, the methods can include determining an average cellular mass of cells in a sample from the subject and/or detecting one or more molecular signatures in one or more of the cells. In some embodiments, treatment includes administering one or more BCR-ABL tyrosine kinase inhibitors or a pharmaceutical formulation thereof, one or more pre-BCR signaling pathway inhibitors or a pharmaceutical formulation thereof, one or more p38 MAPK inhibitors or a pharmaceutical formulation thereof; or any combination thereof.

IPC Classes  ?

  • A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
  • A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
  • A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
  • A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
  • A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 35/02 - Antineoplastic agents specific for leukemia
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

78.

LOW LOSS BROADBAND QUANTUM LIMITED FLOQUET-MODE AMPLIFIER

      
Application Number 17987962
Status Pending
Filing Date 2022-11-16
First Publication Date 2024-05-16
Owner Massachusetts Institute of Technology (USA)
Inventor
  • O'Brien, Kevin
  • Peng, Kaidong

Abstract

A Floquet mode traveling wave parametric amplifier (TWPA) is disclosed. The Floquet mode TWPA comprises a plurality of stages, where each stage is made up of a nonlinear element and a shunt capacitor. The nonlinear elements may be Josephson junctions, or a combination of series and/or parallel Josephson junctions. The Floquet mode TWPA is designed such that the critical current of the nonlinear elements in each stage is not constant. In some embodiments, the ratio of the largest critical current to the smallest critical current in the Floquet mode TWPA is at least 2:1. In some embodiments, the nonlinear elements with the largest critical current are disposed at or near the input or output of the amplifier. In this way, reflections and backward amplification may be minimized. Further, the TWPA is formed using planar capacitors on a high resistivity substrate, or using low loss parallel plate capacitors.

IPC Classes  ?

  • G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
  • G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms
  • H01P 3/00 - Waveguides; Transmission lines of the waveguide type
  • H01P 11/00 - Apparatus or processes specially adapted for manufacturing waveguides or resonators, lines, or other devices of the waveguide type
  • H10N 60/12 - Josephson-effect devices

79.

CROSS-ATTENTION DECODING FOR VOLUMETRIC RENDERING

      
Application Number 18364783
Status Pending
Filing Date 2023-08-03
First Publication Date 2024-05-16
Owner
  • Toyota Research Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • Toyota Jidosha Kabushiki Kaisha (Japan)
Inventor
  • Guizilini, Vitor
  • Ambrus, Rares A.
  • Fang, Jiading
  • Zakharov, Sergey
  • Sitzmann, Vincent
  • Vasiljevic, Igor
  • Gaidon, Adrien

Abstract

Systems and methods described herein support enhanced computer vision capabilities which may be applicable to, for example, autonomous vehicle operation. An example method includes generating a latent space and a decoder based on image data that includes multiple images, where each image has a different viewing frame of a scene. The method also includes generating a volumetric embedding that is representative of a novel viewing frame of the scene. The method includes decoding, with the decoder, the latent space using cross-attention with the volumetric embedding, and generating a novel viewing frame of the scene based on an output of the decoder.

IPC Classes  ?

80.

SHARED LATENT SPACES FOR VOLUMETRIC RENDERING

      
Application Number 18364922
Status Pending
Filing Date 2023-08-03
First Publication Date 2024-05-16
Owner
  • Toyota Research Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • Toyota Jidosha Kabushiki Kaisha (Japan)
Inventor
  • Guizilini, Vitor
  • Ambrus, Rares A.
  • Fang, Jiading
  • Zakharov, Sergey
  • Sitzmann, Vincent
  • Vasiljevic, Igor
  • Gaidon, Adrien

Abstract

Systems and methods described herein support enhanced computer vision capabilities which may be applicable to, for example, autonomous vehicle operation. An example method includes An example method includes training a shared latent space and a first decoder based on first image data that includes multiple images, and training the shared latent space and a second decoder based on second image data that includes multiple images. The method also includes generating a volumetric embedding that is representative of a novel viewing frame the first scene. Further, the method includes decoding, with the first decoders, the shared latent space with the volumetric embedding, and generating the novel viewing frame of the first scene based on the output of the first decoder.

IPC Classes  ?

  • G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle
  • G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]

81.

RADIANT AND VOLUMETRIC LATENT SPACE ENCODING FOR VOLUMETRIC RENDERING

      
Application Number 18364946
Status Pending
Filing Date 2023-08-03
First Publication Date 2024-05-16
Owner
  • Toyota Research Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • Toyota Jidosha Kabushiki Kaisha (Japan)
Inventor
  • Guizilini, Vitor
  • Ambrus, Rares A.
  • Fang, Jiading
  • Zakharov, Sergey
  • Sitzmann, Vincent
  • Vasiljevic, Igor
  • Gaidon, Adrien

Abstract

Systems and methods described herein support enhanced computer vision capabilities which may be applicable to, for example, autonomous vehicle operation. An example method includes generating, through training, a shared latent space based on (i) image data that include multiple images, where each image has a different viewing frame of a scene, and (ii) first and second types of embeddings, and training a decoder based on the first type of embeddings. The method also includes generating an embedding based on the first type of embeddings that is representative of a novel viewing frame of the scene, decoding, with the decoder, the shared latent space using cross-attention with the generated embedding, and generating the novel viewing frame of the scene based on an output of the decoder.

IPC Classes  ?

  • G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
  • G06V 20/40 - Scenes; Scene-specific elements in video content
  • G06V 20/56 - Context or environment of the image exterior to a vehicle by using sensors mounted on the vehicle
  • G06V 20/64 - Three-dimensional objects

82.

LUNG-CANCER SPECIFIC T CELL DYSFUNCTION

      
Application Number 18280775
Status Pending
Filing Date 2022-03-07
First Publication Date 2024-05-16
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Wittrup, Karl Dane
  • Love, J. Christopher
  • Spranger, Stefani
  • Horton, Brendan
  • Morgan, Duncan

Abstract

Methods for identifying patients susceptible to treatment with checkpoint inhibitors are provided herein. Also provided are reagents for analyzing T cell responses for understanding resistance to checkpoint inhibitor therapy and understanding therapeutics for overcoming that resistance. Therapeutic strategies, for instance, for treating cancer, are also provided.

IPC Classes  ?

  • A61K 38/20 - Interleukins
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61P 35/00 - Antineoplastic agents
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

83.

PREDICTING VELOCIMETRY USING MACHINE LEARNING MODELS

      
Application Number 18282679
Status Pending
Filing Date 2022-03-17
First Publication Date 2024-05-16
Owner
  • NANYANG TECHNOLOGICAL UNIVERSITY (Singapore)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • BROWN UNIVERSITY (USA)
Inventor
  • Dao, Ming
  • Suresh, Subra
  • Karniadakis, George
  • Cai, Shengze
  • Li, He

Abstract

Methods and systems for estimating fluid flow characteristics are provided. In one embodiment, a method is provided that includes receiving a plurality of images of fluid flow at a plurality of times. The images may be analyzed with a machine learning model to predict one or more physical characteristics of the fluid flow, such as a velocity field, a pressure field, and/or a stress field. A loss measure may be calculated for the physical characteristics based on physical fluid flow constraints, boundary condition constraints, and/or data mismatch constraints. The machine learning model may be updated based on the loss value.

IPC Classes  ?

84.

Circular RNA For Translation In Eukaryotic Cells

      
Application Number 18544160
Status Pending
Filing Date 2023-12-18
First Publication Date 2024-05-16
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Anderson, Daniel G.
  • Wesselhoeft, Robert Alexander
  • Kowalski, Piotr S.

Abstract

Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3′ Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) a 5′ Group I self-splicing intron fragment.

IPC Classes  ?

  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof

85.

Semiconductor Device with Electric Field Management Structures

      
Application Number 18548704
Status Pending
Filing Date 2022-03-29
First Publication Date 2024-05-16
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Palacios, Tomas
  • Zubair, Ahmad
  • Niroula, John

Abstract

A semiconductor device having an electric field management layer. The electric field management layer comprises a material with a relatively high dielectric constant that minimizes the risk of an electric field within the semiconductor device breaking down and damaging the semiconductor device.

IPC Classes  ?

  • H01L 23/31 - Encapsulation, e.g. encapsulating layers, coatings characterised by the arrangement
  • H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
  • H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
  • H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
  • H01L 29/861 - Diodes
  • H01L 29/872 - Schottky diodes

86.

LOW-TEMPERATURE SYNTHESIS OF TWO-DIMENSIONAL MATERIAL

      
Application Number US2023072193
Publication Number 2024/102506
Status In Force
Filing Date 2023-08-15
Publication Date 2024-05-16
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Zhu, Jiadi
  • Kong, Jing
  • Palacios, Tomas
  • Wang, Jiangtao
  • Park, Ji, Hoon

Abstract

Described herein is a method for depositing a two-dimensional material film on a substrate. In some embodiments, the method comprises using a reactor with two regions to decompose the first precursor. In some embodiments, the method comprises using a higher temperature region to help or accelerate the decomposition of the precursors. In some embodiments, the method comprises placing one or more substrates into the lower temperature region, wherein the temperature will not be high enough to damage the substrate or its nanostructures. In some embodiments, the method comprises depositing a two-dimensional material film and fabricating two-dimensional material devices and circuits at the back end of silicon CMOS circuits.

IPC Classes  ?

  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
  • C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material

87.

ACTIVATION INDUCED CLIPPING SYSTEM (AICS)

      
Application Number US2023079296
Publication Number 2024/102954
Status In Force
Filing Date 2023-11-09
Publication Date 2024-05-16
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • DANA-FARBER CANCER INSTITUTE, INC. (USA)
Inventor
  • Romee, Rizwan
  • Ali, Alaa
  • Chen, Jianzhu

Abstract

Disclosed are nucleic acids encoding fusion proteins containing a target binding domain, a cleavage domain cleavable by A Disintegrin and Metalloproteinase (ADAM) 17, and a transmembrane domain.

IPC Classes  ?

  • C07K 14/735 - Fc receptors
  • C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
  • C07K 19/00 - Hybrid peptides
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
  • A61P 35/00 - Antineoplastic agents

88.

SYSTEMS AND METHODS FOR SUPERVISED REMOTE IMAGING-GUIDED INTERVENTION

      
Application Number US2023036541
Publication Number 2024/097260
Status In Force
Filing Date 2023-10-31
Publication Date 2024-05-10
Owner
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
  • THE GENERAL HOSPITAL CORPORATION (USA)
Inventor
  • Johnson, Matthew R.
  • Brattain, Laura J.
  • Telfer, Brian A.
  • Gjesteby, Lars A.
  • Werblin, Joshua S.
  • Delosa, Nancy D.
  • Samir, Anthony E.
  • Pierce, Theodore T.

Abstract

A method for remote intervention for a subject includes acquiring an image of a region of interest of the subject using an interventional device positioned on the subject and an image acquisition system. The region of interest includes a target structure and the subject is located at a first site. The method further includes analyzing the acquired image using an image analysis module to identify and label the target structure in the region of interest and transmitting the labelled image from the first site to a second site for expert review. The second site is remote from the first site. The method further includes receiving a command signal at the first site from the second site where the command signal is generated based on the expert review of the labelled image and configured to control an action of the interventional device. In some embodiments, the method may further include analyzing the acquired image to determine a pathway to the vessel that avoids critical structures.

IPC Classes  ?

  • A61B 34/35 - Surgical robots for telesurgery
  • A61B 34/37 - Master-slave robots
  • A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
  • A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
  • A61B 17/34 - Trocars; Puncturing needles
  • A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints

89.

TAIL-INTEGRATED BOUNDARY-LAYER INGESTING PROPULSION

      
Application Number JP2023031034
Publication Number 2024/095581
Status In Force
Filing Date 2023-08-28
Publication Date 2024-05-10
Owner
  • MITSUBISHI HEAVY INDUSTRIES, LTD. (Japan)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Imai, Kazuhiro
  • Morisaki, Yuki
  • Yamashita, Satoshi
  • Koike, Yuji
  • Spakovszky, Zoltan
  • Chen, Zhibo
  • Galbraith, Marshall
  • Greitzer, Edward
  • Sabnis, Jayant

Abstract

Propulsion systems, methods and aircraft related to boundary layer ingestion are described. In some embodiments, an aircraft may include a fuselage with a plurality of boundary layer ingesting propulsors may be disposed on and distributed around at least a portion of a 5 perimeter of the fuselage. An annular exit nozzle may be fluidly coupled to a plurality of propulsor outlets of the plurality of propulsors such that an outflow from the plurality of propulsors flows through the annular exit nozzle during operation of the aircraft. In other embodiments, a boundary layer ingesting propulsor may be disposed on the fuselage where a portion of the fuselage upstream from the inlet may be configured to provide a desired Mach 10 number for fluid located within a predetermined distance of the propulsor inlet during cruise of the aircraft.

IPC Classes  ?

  • B64C 21/01 - Boundary layer ingestion [BLI] propulsion
  • B64D 27/20 - Aircraft characterised by the type or position of power plant of jet type within, or attached to, fuselage

90.

FILMS AND DEVICES FOR PHOTON UPCONVERSION OF INFRARED LIGHT

      
Application Number US2023078514
Publication Number 2024/097872
Status In Force
Filing Date 2023-11-02
Publication Date 2024-05-10
Owner
  • REGENTS OF THE UNIVERSITY OF MINNESOTA (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Oh, Sang-Hyun
  • Yoo, Daehan
  • Nelson, Keith A.
  • Shi, Jiaojian

Abstract

An upconversion film or device includes a dielectric layer, a gap electrode layer overlying the dielectric layer, and an upconversion material configured to upconvert infrared light to visible light. The gap electrode layer includes an array of discrete apertures between an array of discrete electrodes and a continuous electrode. Each discrete aperture is defined by a capacitive gap at least partially filled by the upconversion material, An example upconversion film includes capacitive gaps that are each less than 20 nanometers. An example upconversion device includes an optically transparent electrode layer underlying the dielectric layer. An example infrared camera includes an imaging layer that includes an array of sensing elements, in which each discrete aperture is aligned with a sensing element. An example method of manufacturing an upconversion film includes forming a passivation layer on the array of discrete electrodes using atomic layer deposition to form the capacitive gap.

IPC Classes  ?

  • H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
  • G01J 5/20 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using resistors, thermistors or semiconductors sensitive to radiation, e.g. photoconductive devices
  • H01L 31/02 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof - Details
  • H01L 31/055 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means where light is absorbed and re-emitted at a different wavelength by the optical element directly associated or integrated with the PV cell, e.g. by using luminescent material, fluorescent concentrators or up-conversion arrangements

91.

HIGH-TEMPERATURE MINIATURE ULTRASONIC PROBES

      
Application Number US2023035214
Publication Number 2024/097017
Status In Force
Filing Date 2023-10-16
Publication Date 2024-05-10
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • O'Ghaffari, Hoagy
  • Pec, Matej

Abstract

The present disclosure is directed to miniature high-temperature ultrasound probes. A device comprising a high temperature piezo-element is disclosed, which is encapsulated within highly anti-oxidizing and non-corrosive electrodes and has been tested within a high temperature- high pressure system to check the performance of the device. Although the disclosed embodiments are suitable for use in a high temperature ultrasound transducer array, the detailed high temperature-design disclosed herein is not limited to monitoring acoustic emissions and conducting active probes (phase arrival) but can be employed also as pressure (load) sensors if the sensor is characterized and calibrated for a working load and temperature interval.

IPC Classes  ?

  • G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object - Details
  • G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices

92.

Conformable Ultrasound Patch For Cavitation Enchanced Transdermal Drug Delivery

      
Application Number 18500479
Status Pending
Filing Date 2023-11-02
First Publication Date 2024-05-09
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Dagdeviren, Canan
  • Shah, Aastha

Abstract

Described herein is an apparatus, comprising a substrate having a top surface and a bottom surface. In an embodiment, the apparatus comprises one or more piezoelectric transducers having a diameter of about 10 mm and a thickness of about 2 mm, embedded in the substrate. In an embodiment, the apparatus comprises one or more cavitation chambers having a depth of about 1 mm, each of the one or more cavitation chambers disposed between respective ones of the one or more piezoelectric transducers and the top surface of the substrate, wherein the one or more piezoelectric transducers generate vibrations within a frequency range about 20 kHz to about 1 MHz in the cavitation chambers that cause a substance stored in the cavitation chambers to be forcibly moved through the top surface of the substrate.

IPC Classes  ?

  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
  • A61N 7/00 - Ultrasound therapy
  • B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction

93.

DEVICES, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING WIRELESS STENT-BASED INTERFACES TO THE NERVOUS SYSTEM

      
Application Number 18507676
Status Pending
Filing Date 2023-11-13
First Publication Date 2024-05-09
Owner
  • The Trustees of Columbia University in The City of New York (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Shepard, Kenneth L.
  • Stanton, John William
  • Franzesi, Giovanni Talei
  • Boyden, Ed

Abstract

An exemplary vascular neural interface device/configuration and method can be provided for at least one of stimulating or recording the nervous system. For example, a package can be provided which can be inserted within a blood vessel. The package can include at least one transducer, at least one electrode, and at least one integrated circuit. The at least one transducer can receive or transmit a wireless signal which is used to provide energy or communicate with the at least one integrated circuit to at least one of record or stimulate the nervous system using recording electronics or stimulating electronics.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/07 - Endoradiosondes
  • H05K 1/03 - Use of materials for the substrate

94.

SOLAR THERMAL AEROGEL RECEIVER AND MATERIALS THEREFOR

      
Application Number 18508634
Status Pending
Filing Date 2023-11-14
First Publication Date 2024-05-09
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Chen, Gang
  • Wang, Evelyn N.
  • Boriskina, Svetlana
  • Weinstein, Lee A.
  • Yang, Sungwoo
  • Bhatia, Bikramjit S.
  • Zhao, Lin
  • Strobach, Elise M.
  • Cooper, Thomas A.
  • Bierman, David M.
  • Huang, Xiaopeng
  • Loomis, James

Abstract

A silica aerogel having a mean pore size less than 5 nm with a standard deviation of 3 nm. The silica aerogel may have greater than 95% solar-weighted transmittance at a thickness of 8 mm for wavelengths in the range of 250 nm to 2500 nm, and a 400° C. black-body weighted specific extinction coefficient of greater than 8 m2/kg for wavelengths of 1.5 μm to 15 μm. Silica aerogel synthesis methods are described. A solar thermal aerogel receiver (STAR) may include an opaque frame defining an opening, an aerogel layer disposed in the opaque frame, with at least a portion of the aerogel layer being proximate the opening, and a heat transfer fluid pipe in thermal contact with and proximate the aerogel layer. A concentrating solar energy system may include a STAR and at least one reflector to direct sunlight to an opening in the STAR.

IPC Classes  ?

  • C01B 33/158 - Purification; Drying; Dehydrating
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
  • C01B 33/14 - Colloidal silica, e.g. dispersions, gels, sols
  • C04B 14/06 - Quartz; Sand
  • F24S 10/95 - Solar heat collectors using working fluids using internal thermosiphonic circulation having evaporator sections and condenser sections, e.g. heat pipes
  • F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
  • F24S 23/70 - Arrangements for concentrating solar rays for solar heat collectors with reflectors
  • F24S 70/20 - SOLAR HEAT COLLECTORS; SOLAR HEAT SYSTEMS - Details of absorbing elements characterised by surface treatment for increasing absorption
  • F24S 80/56 - Transparent coverings; Elements for transmitting incoming solar rays and preventing outgoing heat radiation characterised by means for preventing heat loss
  • F24S 80/65 - Thermal insulation characterised by the material

95.

COMPOSITIONS AND METHODS FOR DOMINANT ANTIVIRAL THERAPY

      
Application Number 18549951
Status Pending
Filing Date 2022-03-11
First Publication Date 2024-05-09
Owner MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Choueiri, Alexi G.
  • Qian, Yong
  • Li, Bowen
  • Langer, Robert S.
  • Anderson, Daniel G.
  • Boyden, Edward S.

Abstract

In aspects, the invention provides novel compositions and methods for dominant inhibition of viral infection.

IPC Classes  ?

  • C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
  • A61K 38/16 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
  • A61K 38/46 - Hydrolases (3)
  • A61P 31/14 - Antivirals for RNA viruses
  • C12N 9/22 - Ribonucleases

96.

PHYSICS-ENHANCED DEEP SURROGATE

      
Application Number 17982996
Status Pending
Filing Date 2022-11-08
First Publication Date 2024-05-09
Owner
  • International Business Machines Corporation (USA)
  • Massachusetts Institute of Technology (USA)
Inventor
  • Pestourie, Raphael
  • Mroueh, Youssef
  • Das, Payel
  • Johnson, Steven Glenn
  • Rackauckas, Christopher Vincent

Abstract

Surrogate training can include receiving a parameterization of a physical system, where the physical system includes real physical components and the parameterization having corresponding target property in the physical system. The parameterization can be input into a neural network, where the neural network generates a different dimensional parameterization based on the input parameterization. The different dimensional parameterization can be input to a physical model that approximates the physical system. The physical model can be run using the different dimensional parameterization, where the physical model generates an output solution based on the different dimensional parameterization input to the physical model. Based on the output solution and the target property, the neural network can be trained to generate the different dimensional parameterization.

IPC Classes  ?

  • G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

97.

SELF-SUPERVISED DEPTH FOR VOLUMETRIC RENDERING REGULARIZATION

      
Application Number 18364853
Status Pending
Filing Date 2023-08-03
First Publication Date 2024-05-09
Owner
  • Toyota Research Institute, Inc. (USA)
  • Massachusetts Institute of Technology (USA)
  • Toyota Jidosha Kabushiki Kaisha (Japan)
Inventor
  • Guizilini, Vitor
  • Ambrus, Rares A.
  • Fang, Jiading
  • Zakharov, Sergey
  • Sitzmann, Vincent
  • Vasiljevic, Igor
  • Gaidon, Adrien

Abstract

An example method includes generating embeddings of image data that includes multiple images, where each image has a different viewpoints of a scene, generating a latent space and a decoder, wherein the decoder receives embeddings as input to generate an output viewpoint, for each viewpoint in the image data, determining a volumetric rendering view synthesis loss and a multi-view photometric loss, and applying an optimization algorithm to the latent space and the decoder over a number of epochs until the volumetric rendering view synthesis loss is within a volumetric threshold and the multi-view photometric loss is within a multi-view threshold.

IPC Classes  ?

98.

MICRONEEDLE COMPOSITIONS AND METHODS OF DELIVERY USING THE SAME

      
Application Number 18278907
Status Pending
Filing Date 2022-02-28
First Publication Date 2024-05-09
Owner
  • The Brigham and Women`s Hospital, Inc. (USA)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Artzi, Natalie
  • Dosta, Pere
  • Puigmal, Nuria

Abstract

The present disclosure describes microneedle array compositions comprising a plurality of microneedles projecting from a substrate. Each microneedle of the plurality of microneedles comprise a penetrating tip and a base that is integrally connected with the substrate, wherein each microneedle of the plurality of microneedles is a porous microneedle composed of a degradable hyaluronic acid polymer comprising a disulfide bond.

IPC Classes  ?

  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/198 - Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
  • A61K 31/728 - Hyaluronic acid

99.

METHODS OF PREDICTING RESPONSE TO ANTI-TNF BLOCKADE IN INFLAMMATORY BOWEL DISEASE

      
Application Number 18280547
Status Pending
Filing Date 2022-03-09
First Publication Date 2024-05-09
Owner
  • Massachusetts Institute of Technology (USA)
  • Seattle Children's Hospital DBA Seattle Children's Research Institute (USA)
  • The Children's Medical Center Corporation (USA)
Inventor
  • Shalek, Alexander K.
  • Kean, Leslie
  • Ordovas-Montanes, Jose
  • Zheng, Hengqi
  • Doran, Benjamin
  • Kimler, Kyle

Abstract

The subject matter disclosed herein is generally directed to stratifying and treating inflammatory diseases. In particular, the present invention provides for detecting treatment naive cell states that predict the response of a subject having inflammatory bowel disease to anti-TNF-blockade. The cells are T cells, NK cells, innate lymphoid cells, myeloid and/or epithelial cell subsets defined by their gene expression as determined by single cell RNA sequencing. Alternatively, the responders are identified by gene expression in a sample.

IPC Classes  ?

  • C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
  • A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

100.

ENHANCED DEPTH ESTIMATION USING DEEP LEARNING

      
Application Number 18280940
Status Pending
Filing Date 2022-01-06
First Publication Date 2024-05-09
Owner Massachusetts Institute of Technology (USA)
Inventor
  • Wang, Shaoxiong
  • Romero, Branden
  • She, Yu
  • Adelson, Edward

Abstract

Retrographic sensors described herein may provide smaller sensors capable of high-resolution three-dimensional reconstruction of an object in contact with the sensor. Such sensors may be used by robots for work in narrow environments, fine manipulation tasks, and other applications. To provide a smaller sensor, a reduced number of light sources may be provided in the sensor in some embodiments. For example, three light sources, two light sources, or one light source, may be used in some sensors. When fewer light sources are provided, full color gradient information may not be provided. Instead, the missing gradients in one direction or other information related to a three-dimensional object in contact with the sensor may be determined using gradients in a different direction that were provided by the real data. This may be done using a trained statistical model, such as a neural network, in some embodiments.

IPC Classes  ?

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