1859, Inc.

United States of America

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C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters 1
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA 1
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 1
C12Q 1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules 1
C12Q 1/6823 - Release of bound markers 1
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METHODS AND SYSTEMS FOR MICROFLUIDIC SCREENING

      
Document Number 03157359
Status Pending
Filing Date 2020-10-09
Open to Public Date 2021-04-15
Owner 1859, INC. (USA)
Inventor
  • Cayer, Devon
  • Macconnell, Andrew
  • Chubukov, Pavel
  • Ramji, Ramesh
  • Stromberg, Sean

Abstract

Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules
  • C12Q 1/6823 - Release of bound markers
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C40B 20/04 - Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
  • C40B 30/00 - Methods of screening libraries
  • C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
  • C40B 30/06 - Methods of screening libraries by measuring effects on living organisms, tissues or cells
  • C40B 50/10 - Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps
  • C40B 70/00 - Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or barcodes
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing