Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1495 - Calibrating or testing in vivo probes
A system for sensing interstitial glucose includes an elongated structure that defines a fluid delivery conduit having at least one fluid outlet, and a sensor formed on an external surface of the elongated structure and comprising a reference electrode, a counter electrode, and a working electrode arranged planarly in a sequence along a longitudinal axis of the elongated structure and configured to sense an interstitial glucose level of a patient.
A deployment device for deploying a transcutaneous sensor in accordance with an embodiment of the present technology includes a housing including a plunger, a frame, and a cap. The deployment device further includes a spring and a carrier within the housing. The frame defines a deployment window through which the carrier is configured to move the transcutaneous device into contact with a target surface of a subject. This can occur at least partially in response to the frame moving in a second direction relative to the plunger, the second direction being opposite the first direction. The deployment device also include a stop that, when engaged, is configured block separation of the cap from the plunger, thereby enabling the spring to be removed from the housing. The stop is configured to disengage at least partially in response to the frame moving in the second direction relative to the plunger.
The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.
Removable devices wearable on a user's skin and methods for using such devices are provided. An exemplary removable device includes a skin adhesive configured to adhere to the skin, a durable component, and an interface component interconnecting the durable component and the skin adhesive. The device separates at the interface component to remove the durable component from the skin adhesive upon application of a removal force to the device.
An analyte biosensor is provided having an analyte biosensing layer and an ethylene oxide absorption layer. The ethylene oxide absorption layer is provided over the analyte biosensing layer. A method is also provided.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
A hydraulically actuated valve device includes a valve body having an inner cavity, an inlet channel extending to the inner cavity, an outlet channel extending from the inner cavity, and an open end that opens to the inner cavity. A septum is located in the inner cavity to seal the open end of the valve body and to receive a needle through which an operating fluid may be selectively injected into or withdrawn from the inner cavity to increase or reduce a fluid pressure in the inner cavity. A valve closing member has an unactuated state to enable a first fluid to flow from the inlet channel to the outlet channel when the fluid pressure of operating fluid in the inner cavity of the valve body is below a closing pressure, and inhibits the first fluid from flowing out of the inner cavity through the outlet channel when the operating fluid in the inner cavity of the valve body is at or above the closing pressure.
This disclosure generally relates to medical devices that include a sensor transmitter assembly that includes a sensor assembly including a sensor module where a first sensor including a first sensor head having at least one first sensor contact pad is combined with a second sensor including a second sensor head having at least one second sensor contact pad. The sensor transmitter assembly also includes a transmitter assembly positioned on a top of the sensor assembly to form a single unit, the transmitter assembly having at least one transmitter contact disposed on a base of the transmitter assembly, where the first sensor contact pad(s) and the second sensor form a connection path with the transmitter contact(s).
Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising an analyte modulating layer formed from acrylate hydrogel composition that modulates the diffusion of glucose through the analyte modulating layer and which further comprises a bioactive agent selected to enhance the biocompatibility of analyte sensors when implanted in vivo.
A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
12.
DETACHMENT MECHANISM OF A WEARABLE INFUSION DEVICE AND RELATED TECHNOLOGY
A detachable component of a wearable medical device in accordance with an embodiment of the present technology includes a housing and a latch operably associated with the housing. The latch includes a cam having a first position at which the cam projects outwardly from the housing, a second position at which the cam is shifted inwardly relative to the first position, and a third position at which the cam is shifted inwardly relative to the second position. The cam is resiliently biased from the second position toward the first position. Fully actuating the cam moves the cam from the first position to the second position. The detachable component further includes a handle accessible from outside the housing. The handle is movable in an actuating direction to move the cam from the first or second position to the third position.
A fluid delivery system and a fluid conduit assembly suitable for use with the system are disclosed herein. The system includes a fluid infusion pump and a fluid conduit assembly coupled to the pump to deliver medication fluid to a user. The fluid conduit assembly includes a structure defining a flow path for the medication fluid, and a gas trapping filter coupled to the structure and positioned in the flow path. The gas trapping filter functions to filter particulates from the medication fluid and retain gas bubbles from the medication fluid.
A61M 5/38 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
A61M 5/162 - Needle sets, i.e. connections by puncture between reservoir and tube
A medical device includes a base having a first surface to be secured to a patient's skin. A first insertable member has a length portion extending from the first surface of the base for insertion. A second insertable member has a length portion extending from the first surface of the base for insertion through the patient's skin. The first insertable member includes a sensor member for sensing a biological condition, and the second insertable member includes an infusion cannula for infusing an infusion media. The distal end of the first insertable member and the distal end of the second insertable member are spaced apart by a first distance of at least 5.0 mm, for reducing interference of the infusion media from the infusion cannula with an operation of the sensor member.
A method for compensating for a life-lengthening agent for a glucose sensor includes accessing first and second electrochemical impedance spectroscopy (EIS) values of at least one parameter based on first and second EIS procedures performed on EIS signals from a working electrode of the glucose sensor, calculating a change in the at least one parameter between the first and second EIS values, estimating a concentration of the agent based on the change in the at least one parameter, and calculating a model effect in response to the concentration. In a case where the model effect is not greater than the threshold, the method further includes adjusting a sensor glucose value based on the concentration and sensor signals from the working electrode, and displaying the adjusted sensor glucose value.
Systems and methods for forming probes for a biosensor. In the systems and methods disclosed herein, a base substrate is provided; and a platinum layer is formed on the base substrate by sputtering platinum in the absence of oxygen. The platinum layer is formed using a sputtering pressure of at least 30 mtorr.
An example device includes an electrochemical cell configured to generate a first electrical signal indicative of an amount of glucose in a fluid of a person, the electrochemical cell comprising a working electrode, a counter electrode, and a reference electrode; and a background electrode configured to not catalyze a reaction with glucose and is configured to generate a second electrical signal indicative of an amount of electrochemical interference proximate the electrochemical cell.
A device in accordance with an embodiment of the present technology includes a port through which the device receives and dispenses infusion liquid (e.g., insulin solution) and a container that holds the infusion liquid. The device also includes a hub at a flowpath extending between the port and the container. The hub defines a first passage and a second passage in parallel with one another. The device further includes a conditioner and a check valve at the first and second passages, respectively. The conditioner conditions liquid moving between the container and the port by passing the liquid through an adsorbent filter and a mechanical filter. The check valve causes liquid moving between the port and the container to move preferentially via the first passage when flowing in one direction and to move preferentially via the second passage when flowing in an opposite direction.
A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programing (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
20.
SENSOR CALIBRATION USING SIMULATED SENSOR MEASUREMENTS
Techniques for sensor calibration involve determining a generative model using sensor measurements from different instances of a first glucose sensor together with corresponding reference glucose values. The generative model is configured to generate a simulated measurement representing a predicted output of the first glucose sensor under specific operating conditions. A set of simulated measurements is generated using operating conditions observed with respect to a second glucose sensor as inputs to the generative model. The second glucose sensor is a sensor of a different design. The operating conditions observed with respect to the second glucose sensor include reference glucose values obtained in connection with measurements made using the second glucose sensor. The simulated measurements are then used to determine an estimation model for the first glucose sensor. The estimation model is configured to estimate glucose level given one or more sensor measurements from the first glucose sensor.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G06F 18/214 - Generating training patterns; Bootstrap methods, e.g. bagging or boosting
G06N 3/088 - Non-supervised learning, e.g. competitive learning
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
21.
THERMALLY STABLE GLUCOSE LIMITING MEMBRANE FOR GLUCOSE SENSORS
Embodiments of the invention provide compositions useful in analyte sensors as well as methods for making and using such compositions and sensors. In typical embodiments of the invention, the sensor is a glucose sensor comprising an analyte modulating membrane formed from a polymeric reaction mixture formed to include limiting amounts of catalyst and/or polycarbonate compounds so as to provide such membranes with improved material properties such as enhanced thermal and hydrolytic stability.
A disposable medical introduction system including a medical device and a disposable inserter. The disposable inserter includes a carrier to receive the medical device. The carrier includes at least one annular projection. The disposable inserter includes a retractor received within the at least one annular projection and movable relative to the at least one annular projection. The retractor has at least one retaining arm. The disposable inserter includes a needle cartridge coupled to the retractor that includes an insertion needle. The at least one retaining arm cooperates with the needle cartridge to maintain the insertion needle in a first, extended state. A movement of the retractor relative to the at least one annular projection releases the at least one retaining arm to move the insertion needle from the first, extended state to a second, retracted state.
A sensor assembly for sensing a physiological characteristic includes a power source, a power control switch, and a power latch configured to latch an output of the power control switch. The sensor assembly also includes a power converter coupled to the power control switch. The power converter is configured to step down a voltage of the latched output of the power control switch for delivery of the latched output to one or more components of the sensor assembly. The power control switch is configured to inhibit consumption of power from the power source when the sensor assembly is in a pre-deployment state and output the latched output to the power converter in response to transition of the sensor assembly from the pre-deployment state to a deployed state.
Embodiments are provided for dynamic management of charge. The techniques may involve obtaining an estimated readiness time for an energy storage element, obtaining a target state of charge for the energy storage element, calculating an estimated charging time based at least in part on a difference between the target state of charge and a current state of charge, using a first charging rate to charge the energy storage element to an intermediate state of charge, and responsive to determining the amount of time remaining before reaching a second estimated readiness time is less than an updated estimated charging time to charge the energy storage element at the intermediate state of charge to the target state of charge, using a second charging rate to charge the energy storage element to the target state of charge, wherein the second charging rate is greater than the first charging rate.
A sensor assembly for sensing a physiological characteristic includes a power source configured to deliver power to one or more components of an electrical subsystem upon deployment of the sensor assembly to a user. A power latch is configured to latch an output of a power control switch for delivery to one or more components of the electrical subsystem upon deployment of the sensor assembly to a user. The power control switch is configured to inhibit delivery of power to the electrical subsystem prior to deployment of the sensor assembly to a user and to deliver the latched output to one or more components of the electrical subsystem in response to deployment of the sensor assembly to a user.
Techniques disclosed herein relate to infusion devices and alerts. In some embodiments, the techniques may involve identifying an amount of future insulin deliveries to be delivered by an infusion device. The techniques may further involve determining a homeostasis metric by predicting a change in a current glucose measurement value based on accounting for metabolism of a current amount of active insulin and the amount of future insulin deliveries. The techniques may further involve generating an alert based at least in part on the homeostasis metric.
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
27.
METHOD AND APPARATUS FOR TRACKING OF FOOD INTAKE AND OTHER BEHAVIORS AND PROVIDING RELEVANT FEEDBACK
A sensing device monitors and tracks food intake events and details. A processor, appropriately programmed, controls aspects of the sensing device to capture data, store data, analyze data and provide suitable feedback related to food intake. More generally, the methods might include detecting, identifying, analyzing, quantifying, tracking, processing and/or influencing, related to the intake of food, eating habits, eating patterns, and/or triggers for food intake events, eating habits, or eating patterns. Feedback might be targeted for influencing the intake of food, eating habits, or eating patterns, and/or triggers for those. The sensing device can also be used to track and provide feedback beyond food-related behaviors and more generally track behavior events, detect behavior event triggers and behavior event patterns and provide suitable feedback.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
G06F 1/16 - Constructional details or arrangements
An insertion device configured to implant a first medical device and a second medical device in a user. The first medical device may be a fluid delivery cannula configured to deliver a fluid (e.g., insulin) to the user. The second medical device may be an analyte sensor (e.g., a glucose sensor) configured to detect a physiological characteristic of the user (e.g., a glucose level). The insertion device may be configured to be worn by the user. The insertion device includes a first linkage assembly configured to extend and retract a first insertion needle to implant the first medical device and a second linkage assembly configured to extend and retract a second insertion needle to implant the second medical device. The insertion device includes a user input device configured to cause the insertion device to initiate the implantation when activated by the user.
A system for a physiological characteristic sensor deployed with a sensor inserter includes an adhesive skin patch coupled to the physiological characteristic sensor. The adhesive patch is to couple the physiological characteristic sensor to an anatomy. The system also includes a gravity resistance system coupled to the adhesive patch and to be coupled to the sensor inserter. The gravity resistance system maintains the adhesive patch substantially perpendicular to a longitudinal axis of the sensor inserter prior to deployment of the physiological characteristic sensor and is removable from the adhesive patch by the sensor inserter upon deployment of the physiological characteristic sensor.
Methods, systems and non-transient computer-readable media are provided for optimizing sensor wear and/or longevity of a personalized model used for estimating glucose values.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
31.
MINIMIZING SKIN IRRITATION DUE TO SKIN ADHESION PATCHES
The invention provides a skin adhesive patch that inhibits skin irritation by releasing an anti-inflammatory agent such as a corticosteroid topically on the skin surface. Embodiments of the invention can be adapted for use with a wide variety of adhesive patches that are used to couple medical components to the skin of patients such as the devices that diabetic patients use including insulin infusion sets, patch pumps, and all-in-one patch sets.
Techniques disclosed herein relate to gesture-based control of diabetes therapy. In some embodiments, the techniques may involve identifying at least one gesture indicative of utilization of an injection device for preparation of an insulin injection based on user activity data obtained from a wearable device disposed on an arm of a user. The techniques may further involve based on the at least one identified gesture, determining whether the insulin injection meets criteria of a proper insulin injection. The techniques may further involve outputting information indicative of whether the criteria is satisfied based on the determination.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
H04W 4/02 - Services making use of location information
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 70/40 - ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
Techniques disclosed herein relate to infusion devices and related meal bolus adjustment methods. In some embodiments, the techniques may involve determining an initial bolus amount. The techniques may further involve predicting a value for a first physiological condition based at least in part on the initial bolus amount. The techniques may further involve when the predicted value for the first physiological condition violates a threshold: identifying an adjusted bolus amount that results in the predicted value for the first physiological condition satisfying the threshold, and causing delivery of the adjusted bolus amount.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
34.
METHODS AND SYSTEMS FOR UPDATING MODELS USED FOR ESTIMATING GLUCOSE VALUES
Methods, systems and non-transient computer-readable media are provided for updating models used for estimating glucose values. For example, technologies are provided for updating an existing population model for estimating glucose values for a population of users to generate a new updated population model for a subset of users of the population of users. As another example, technologies are provided for updating an existing personalized model for estimating glucose values to generate a new updated personalized model that is personalized for a particular user.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
35.
INTELLIGENT MEDICATION DELIVERY SYSTEMS AND METHODS USING A PRESCRIPTION-REGULATED SOFTWARE APPLICATION
Systems, devices and methods are disclosed for a prescription-regulated software application and an associated medical device. In some aspects, a smart medicine-injection device (e.g., smart insulin pen) is configured to be in communication with a patient's companion device (e.g., smartphone) having a software application (prescription app) that serves the patient as a complimentary medical device to the smart medicine-injection device, in which only certain features and functionalities of the prescription app are fully operable based on device pairing with the smart medicine-injection device to unlock medical device capabilities only available to the patient through prescription.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
36.
Safeguards against separation from portable medicine delivery devices
Disclosed herein are techniques related to safeguards against separation from portable medicine delivery devices. In some embodiments, the techniques may involve monitoring a wireless connection established between a portable computing device and a portable medicine delivery device. The techniques may also involve making a determination, based on the result of the monitoring, that the portable medicine delivery device is outside a predetermined range of the portable computing device. The techniques may further involve generating a notification based on the determination. The notification may be indicative of a user of the portable computing device being unaccompanied by the portable medicine delivery device.
Disclosed herein are techniques related to safeguards against usage of incorrect portable medicine delivery devices. Such techniques may be practiced for a plurality of portable medicine delivery devices that include a first device and a second device. The techniques may involve obtaining usage data indicative of the first device being manipulated in preparation for medicine delivery. The techniques may further involve determining, based on the usage data, that the first device is mistakenly being manipulated instead of the second device. The technique may also involve, responsive to determining that the first device is mistakenly being manipulated, generating a message to prevent medicine delivery by the first device.
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
38.
Real-time meal detection based on sensor glucose and estimated plasma insulin levels
Disclosed herein are techniques related to automatic real-time meal detection. In some embodiments, the techniques involve obtaining a plurality of glucose concentration values and a plurality of plasma insulin concentration estimations, each glucose concentration value corresponding with a respective plasma insulin concentration estimation; generating an output based on applying a meal detection model to the plurality of glucose concentration values and the plurality of plasma insulin concentration estimations; and determining, based on the output, that a glucose concentration value of the plurality of glucose concentration values corresponds to an ongoing glycemic response to a meal.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
Techniques disclosed herein relate to continuous analyte sensor quality measures. In some embodiments, the techniques may involve obtaining a current sensor-generated value that is indicative of a physiological characteristic of a user of a medical device, the current sensor-generated value produced in response to operation of a continuous analyte sensor device. The techniques may further involve obtaining a sensor quality metric that indicates accuracy of the current sensor-generated value. The techniques may further involve causing, in response to obtaining the sensor quality metric, configuration of a quality-specific operating mode of the medical device, the quality-specific operating mode comprising separate regulation of basal and bolus deliveries of a fluid medication based on the obtained sensor quality metric. The techniques may further involve causing regulation of fluid medication delivery from the medical device, in accordance with the current sensor-generated value and the quality-specific operating mode of the medical device.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
40.
FLUID DELIVERY ADJUSTMENTS BASED ON PREDICTED PHYSIOLOGICAL CONDITIONS
Techniques disclosed herein relate to operating a fluid delivery device in a personalized manner based at least in part on historical data of a patient. In some embodiments, the techniques involve determining a predicted physiological condition of a patient in response to a future activity of the patient, based at least in part on historical data corresponding to the future activity for the patient; determining, based at least in part on the predicted physiological condition of the patient, an adjustment to fluid delivery to the patient by a medical device to prospectively account for the future activity; and operating the medical device to deliver a fluid to the patient in accordance with the adjustment.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
41.
AMBULATORY INFUSION PUMPS AND ASSEMBLIES FOR USE WITH SAME
Ambulatory infusion pumps, medicament reservoirs, and medicament sealing assemblies, including a variety of trocar seal assemblies and fill plug seal assemblies, plus related components, as well as component combinations and related methods.
Disclosed are methods and corresponding systems and devices for controlling which communication interface is used for communication in a wireless body area network of medical devices. In some aspects, a security level for data to be transmitted from a first device to a second device is determined. The first device includes a first communication interface and a second communication interface. Signals communicated over the second communication interface (e.g., a near-field communication interface) have a shorter range compared to the first communication interface (e.g., a far-field communication interface). The data is transmitted using the second communication interface based on determining that the security level for the data is higher than that associated with the first communication interface. In some instances, transmission of the data involves switching to the second communication interface after establishing an initial communication channel using the first communication interface.
Disclosed are methods and corresponding systems and devices for providing an estimation model for use with one or more instances of a particular sensor. In some aspects, an estimation model usable for estimating a value of a physiological condition is determined based at least in part on simulated measurements. The simulated measurements are generated for a first sensor, through applying a translation model to convert historical measurements associated with a second sensor into measurements that would have been produced by the first sensor. The second sensor has a different design or configuration than the first sensor. The historical measurements represent changes in the physiological condition as observed by different instances of the second sensor. The estimation model can be made available to one or more electronic devices, including at least one device configured to apply the estimation model to a measurement from a corresponding instance of the first sensor.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G06F 18/214 - Generating training patterns; Bootstrap methods, e.g. bagging or boosting
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
44.
GLUCOSE MANAGEMENT RECOMMENDATIONS BASED ON NUTRITIONAL INFORMATION
Techniques disclosed herein relate to glucose management recommendations based on nutritional information. In some embodiments, the techniques may involve obtaining user input that includes textual input indicating quantitative information for a food item. The techniques may also involve determining, based on the quantitative information for the food item, nutritional information for the food item, where the quantitative information for the food item is different from the nutritional information for the food item. The techniques may further involve generating, based on the nutritional information, a glucose management recommendation.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
45.
FLEXIBLE CANNULA INSERTION DEVICE, SYSTEM AND PROCESS
An insertion set system includes a base configured to be secured to a patient, and a flexible tubing on the base. The flexible tubing has a distal end portion forming a cannula to be inserted into the patient. An inserter having a needle is received by the base. The needle has a channel in which the distal end portion of the flexible tubing is received. The needle is able to slide relative to the flexible tubing, to selectively withdraw the needle off of the distal end portion of the flexible tubing. The base may include a passage for fluid flow arranged transverse to the axial dimension of the distal end portion of the flexible tubing.
Disclosed herein are techniques related to product consumption recommendations. In some embodiments, the techniques may involve receiving activity data from an activity monitoring device. The activity monitoring device may comprise an activity sensor for tracking movement of a user during an activity. The techniques may also involve receiving glucose data from a continuous glucose monitoring device. The techniques may further involve determining a product consumption recommendation based on the glucose data and the activity data. The product consumption recommendation may include a recommendation of when the user should consume a carbohydrate-containing product in order to maintain glucose levels with a specified target range during the activity. Additionally, the technique may involve causing display of the product consumption recommendation on a display device
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation
G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
47.
MEDICAL DEVICES AND RELATED EVENT PATTERN TREATMENT RECOMMENDATION METHODS
Methods, systems, and media for event pattern treatment recommendations are provided. In some embodiments, a method involve identifying a plurality of event patterns within a plurality of monitoring periods based on measurement values of a physiological condition. The techniques may involve causing display of a snapshot graphical user interface display, wherein the snapshot graphical user interface display comprises a graph overlay region and an event detection region, the graph overlay region comprises a graphical representation of the measurement values, and the event detection region comprises a pattern guidance display for at least a subset of the plurality of event patterns, wherein the pattern guidance display for at least one event pattern includes a graphical representation of a recommended therapeutic remedial action that comprises therapy parameters, to be used by a medical device during a subsequent time period, configured to mitigate occurrence of the at least one event pattern.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G06T 11/20 - Drawing from basic elements, e.g. lines or circles
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Techniques disclosed herein relate to safe correction boluses. In some embodiments, the techniques involve predicting a future glucose level that would result from delivery of a correction bolus. The techniques may also involve comparing the future glucose level to a threshold level for hypoglycemia. The techniques may further involve causing delivery of the correction bolus when the future glucose level is above the threshold level for hypoglycemia.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. The amperometric analyte sensor apparatus comprises: a base layer; a conductive layer disposed on the base layer and comprising a working electrode; an interference rejection membrane disposed on an electroactive surface of the working electrode, wherein the interference rejection membrane comprises silicon-oxygen polymers; and an analyte sensing layer. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.
Provided is a system for delivering and recording a dose of a medicament to a patient. Also provided is a method of administering a medicament to a patient Additionally provided is a method of tracking usage of a medicament by a patient through a pen.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
52.
REDUCING SENSOR FOREIGN BODY RESPONSE VIA HIGH SURFACE AREA METAL STRUCTURES
Embodiments of the invention provide optimized sputtered metallic surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These sputtered metallic surfaces have features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a sputtered metallic surface adapted to contact an in vivo environment.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
Analyte sensors and associated insertion devices are disclosed herein. According to some embodiments, the present technology includes a sensor applicator comprising a housing having an insertion end configured to be positioned at or adjacent a user's skin at an insertion site, a needle carried by the housing and configured for insertion into the user's skin at the insertion site, and a sensor assembly comprising a base and a sensing portion extending from the base. The base is supported by the housing in a first position during insertion of the needle and configured to rotate into a second, laid-flat position on the user's skin after removal of the housing from the insertion site.
Integrated sensor and infusion devices are disclosed herein. The present technology includes, for example, an integrated sensor and infusion device for sensing physiological parameter(s) and delivering a medicament to a body of a user based at least in part on the sensed parameter(s). The device can comprise an insertion assembly comprising a carrier assembly comprising a cannula carrier, a trocar assembly removably coupled to the carrier assembly, and a drive assembly comprising a torsion spring coupled to the trocar assembly such that, when actuated, the torsion spring rotates to drive the trocar assembly and the carrier assembly axially downward to insert an infusion cannula and sensor electrode into a user's skin. The drive assembly can comprise a plurality of coupled drive wheels and/or a scissor assembly with multiple interacting links.
Techniques related to temporary setpoint values are disclosed. The techniques may involve causing operation of a fluid delivery device in a closed-loop mode for automatically delivering fluid based on a difference between a first setpoint value and an analyte concentration value during operation of the fluid delivery device in the closed-loop mode. Additionally, the techniques may involve obtaining a second setpoint value. The second setpoint value may be a temporary setpoint value to be used for a period of time to regulate fluid delivery, and the second setpoint value may be greater than the first setpoint value. The techniques may further involve causing operation of the fluid delivery device for automatically reducing fluid delivery for the period of time based on the second setpoint value.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
56.
TECHNIQUES FOR MANAGING FLUID DELIVERY DEVICE OPERATING MODE TRANSITIONS
Techniques disclosed herein relate to managing transitions into fluid delivery device operating modes. In some embodiments, the techniques involve obtaining status information pertaining to operation of a fluid delivery device, the status information including fluid delivery data, exiting a closed-loop operating mode of the fluid delivery device based on the status information, and, after exiting the closed-loop operating mode, causing generation of a user notification recommending a remedial action to improve viability of a subsequent instance of the closed-loop operating mode. The closed-loop operating mode is an operating mode in which dosage commands are automatically generated based on sensor measurement data.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
57.
INTELLIGENT MEDICATION DELIVERY SYSTEMS AND METHODS FOR MEDICINE DOSE CALCULATION AND REPORTING
Systems, devices, and techniques are disclosed for administering and tracking medicine to patients and providing health management capabilities for patients and caregivers. In some aspects, a system includes an injection pen device in communication with a mobile communication device having a software application to determine a recommended dose based on prior dose data, analyte data, and nutrient data and to generate a report illustrative of a relationship between the medicine data, the health data, and the contextual data.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
58.
MEDICATION FLUID INFUSION SET COMPONENT WITH INTEGRATED PHYSIOLOGICAL ANALYTE SENSOR, AND CORRESPONDING FLUID INFUSION DEVICE
Disclosed is a medical device component for delivering medication fluid to a patient. The medical device component includes a fluid infusion device to regulate delivery of medication fluid, a body-mountable base unit, and a top cover assembly that is removably couplable to the base unit and to the fluid infusion device. The base unit includes a cannula to deliver medication fluid under the control of the fluid infusion device, and a physiological analyte sensor to measure a physiological characteristic. The base unit also includes an electronics assembly electrically connected to sensor leads to obtain measurements in the analog domain, to convert measurements into digital sensor data, and to communicate conditioned digital sensor data to the fluid infusion device. The top cover assembly is configured to provide both fluid and electrical connections for the base unit, by way of an infusion tube having sensor conductors integrated therein or otherwise associated therewith.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
59.
RESERVOIR CONNECTION INTERFACE WITH DETECTABLE SIGNATURE
A connector interface system includes a cap to connect to a reservoir to form a reservoir/cap unit for installation into an infusion pump device. The cap has at least one receptacle for receiving one or more detectable features comprising at least one disc-shaped member, for detection by at least one sensor element on the infusion pump device when the reservoir of the reservoir/cap unit is received in a reservoir receptacle of the infusion pump device. The at least one detectable feature has at least one detectable parameter that is associated with one or more characteristics of the cap, the reservoir, the infusion pump device, a cannula associated with the cap or a tubing connected between the cap and the cannula.
The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
61.
KETONE LIMITING MEMBRANE AND DUAL LAYER MEMBRANE APPROACH FOR KETONE SENSING
The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes dual layer membrane compositions, elements and methods useful with such amperometric analyte sensor systems.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
Techniques disclosed herein relate generally to sensor error mitigation. In some embodiments, the techniques involve identifying an error metric associated with an input variable to a translation model, determining a reference output of the translation model by providing a reference input value for the input variable to the translation model, generating a modulated value for the input variable based on the reference input value using the error metric, determining a simulated output of the translation model by providing the modulated value for the input variable to the translation model, and updating the translation with a reduced weighting applied to the input variable when a difference between the simulated output and the reference output is greater than a threshold.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
63.
REAL-TIME MEAL DETECTION BASED ON SENSOR GLUCOSE AND ESTIMATED PLASMA INSULIN LEVELS
Disclosed herein are techniques related to automatic real-time meal detection. In some embodiments, the techniques involve obtaining a plurality of glucose concentration values and a plurality of plasma insulin concentration estimations, each glucose concentration value corresponding with a respective plasma insulin concentration estimation; generating an output based on applying a meal detection model to the plurality of glucose concentration values and the plurality of plasma insulin concentration estimations; and determining, based on the output, that a glucose concentration value of the plurality of glucose concentration values corresponds to an ongoing glycemic response to a meal.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Disclosed herein are techniques related to delivery of correction boluses. In some embodiments, the techniques involve obtaining data indicative of an ongoing glycemic response to a meal; and causing delivery of one or more correction boluses to at least partially counteract the ongoing glycemic response to the meal.
Techniques disclosed herein relate generally to alert management based on sleeping status. In some embodiments, the techniques involve obtaining user status data indicative of a sleeping status of a user of a medical device, and controlling alert generation and output associated with the medical device in accordance with the sleeping status of the user.
A method includes monitoring, via a device including an electrochemical cell, an electrical current that is proportional to an impedance of the electrochemical cell, and responsive to determining that the electrical current satisfies a threshold, measuring, via the device, a plurality of impedances of the electrochemical cell corresponding to a plurality of frequencies. The method further includes determining a charge transfer conductance and a solution resistance based on the plurality of impedances at fewer than four of the corresponding plurality of frequencies and determining the presence of electrochemical interference based on the solution resistance and the charge transfer conductance. The method further includes outputting an alert based on the determination of the presence of electrochemical interference.
A61B 5/1495 - Calibrating or testing in vivo probes
G01N 27/08 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid which is flowing continuously
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
67.
USE OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS) IN GROSS FAILURE ANALYSIS
Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration. gross (sensor) failure analysis, and intelligent sensor diagnostics and faith detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1495 - Calibrating or testing in vivo probes
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
In some examples, a system for monitoring glucose includes processing circuitry and a glucose monitor comprising one or more monitor electrodes and one or more working electrodes, wherein a first chemistry stack is disposed on at least one of the monitor electrode(s) and a second chemistry stack is disposed on at least one of the working electrode(s). The processing circuitry may be configured to measure one or more calibration values of an operating parameter of the monitor electrode(s), retrieve one or more pre-calibration values of the operating parameter of the monitor electrode(s), wherein the pre-calibration value(s) were measured before the calibration value, determine one or more delta values using the calibration value(s) and the pre-calibration value(s), and calibrate glucose values sensed by the working electrode(s) using the delta value(s).
An electronic device includes a battery, a system load, a switch in an electrical connection path between the battery and the system load, a non-contact sensor configured to detect a wireless control signal associated with an instruction, a control circuit configured to open the switch to disconnect the battery and the system load in response to the detected wireless control signal, and a charging interface configured to receive electric power from an external source, where the control circuit and the non-contact sensor are powered through the charging interface rather than the battery.
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods.
A fluid delivery system and a fluid conduit assembly suitable for use with the system are disclosed herein. The system includes a fluid infusion pump and a fluid conduit assembly coupled to the pump to deliver medication fluid to a user. The fluid conduit assembly includes a structure defining a flow path for the medication fluid, and a gas trapping filter coupled to the structure and positioned in the flow path. The gas trapping filter functions to filter particulates from the medication fluid and retain gas bubbles from the medication fluid. The structure includes at least one retaining feature to inhibit movement of the gas trapping filter.
A61M 5/38 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
A system includes an electronic device and an auxiliary device for charging the electronic device and facilitating hardware shutdown/reset of the electronic device when the electronic device is being charged. The system includes an input user interface (e.g., on the auxiliary device or the electronic device) configured to receive a user input for hardware shutdown/reset of the electronic device. The electronic device includes a switch between a battery and a system load, a control circuit configured to open the switch to disconnect the battery and the system load, and a charging interface configured to receive electric power signals from the auxiliary device to power the control circuit, such that hardware shutdown/reset of the electronic device is performed when the electronic device is being charged, thereby preventing unintentional hardware shutdown/reset during normal use. In some embodiments, wireless control signals are used to initiate hardware shutdown/reset on the electronic device.
An auxiliary device for charging and facilitating hardware shutdown/reset of an electronic device includes a charge transmitter configured to transmit electric power signals, an input user interface for receiving a user input, a wireless control signal transmitter configured to transmit wireless control signals, and a microcontroller unit (MCU). The MC is configured to: determine a user instruction based on the user input; enable the wireless control signal transmitter to transmit a wireless control signal in response to the user instruction; and control the charge transmitter to selectively transmit the electric power signals according to a timing sequence selected based on the user instruction. In some embodiments, the input user interface and the wireless control signal transmitter are a same device (e.g., a slidable magnet).
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
74.
MEDICINE ADMINISTERING SYSTEM INCLUDING INJECTION PEN AND COMPANION DEVICE
Methods, systems, and devices are disclosed for administering a medicament to a patient. In one aspect, a system includes an injection pen device in wireless communication with a mobile communication device. The injection pen device includes a housing including a chamber to encase a cartridge containing medicine, a dose setting and dispensing mechanism to set the mechanism to dispense a particular dose of the medicine from the loaded cartridge, a sensor unit to detect a dispensed dose based on positions and/or movements of the dose setting and dispensing mechanism, and an electronics unit in communication with the sensor unit to process the detected dispensed dose and time data associated with a dispensing event and to wirelessly transmit the dose data to a user's device. The mobile communication device provides a software application to provide the user with health information using the processed dose data.
H04B 7/24 - Radio transmission systems, i.e. using radiation field for communication between two or more posts
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
75.
GLUCOSE ESTIMATION WITHOUT CONTINUOUS GLUCOSE MONITORING
Disclosed herein are techniques related to glucose estimation without continuous glucose monitoring. In some embodiments, the techniques may involve receiving input data associated with a user. The input data may comprise discrete blood glucose measurement data associated with the user, activity data associated with the user, contextual data associated with the user, or a combination thereof. The techniques may also involve using an estimation model and the input data associated with the user to generate one or more estimated blood glucose values associated with the user.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A medical device includes a base having a needle channel and a first surface configured to be secured to a patient's skin. An insertable member is configured to be secured to the base with a length portion of the insertable member extending out of the needle channel at the first surface, for insertion through the patient's skin at an insertion site. A septum extends across the needle channel. The septum has a body through which an insertion needle may be selectively extended to facilitate the subcutaneous insertion of the length portion of the insertable member. The septum provides a liquid seal across the needle channel. The needle channel and the septum provide a sealed volume in which a limited amount of blood or other fluid from the insertion site may be held.
The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.
C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
78.
PREDICTION BASED DELIVERING OR GUIDING OF THERAPY FOR DIABETES
An example system for therapy delivery includes one or more processors configured to in response to a prediction indicating that the meal event is to occur, output instructions to an insulin delivery device to deliver a partial therapy dosage, to a device to notify the patient to use the insulin delivery device to take the partial therapy dosage, or to the insulin delivery device to prepare the partial therapy dosage prior to the meal event occurring, and in response to a determination indicating that the meal event is occurring (e.g., based on movement characteristics of a patient arm), output instructions to the insulin delivery device to deliver a remaining therapy dosage, to the device to notify the patient to use the insulin delivery device to take the remaining therapy dosage, or to the insulin delivery device to prepare the remaining therapy dosage.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 70/40 - ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
H04W 4/02 - Services making use of location information
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
80.
Sensor measurement value calibration using sensor calibration data and a performance model
Techniques disclosed herein relate to determining a calibrated measurement value indicative of a physiological condition of a patient using sensor calibration data and a performance model. In some embodiments, the techniques involve obtaining one or more electrical signals from a sensing element of a sensing arrangement, where the one or more electrical signals are influenced by a physiological condition in a body of a patient. The techniques also involve obtaining calibration data associated with the sensing element from a data storage element of the sensing arrangement, converting the one or more electrical signals into one or more calibrated measurement parameters using the calibration data, obtaining a performance model associated with the sensing element, obtaining personal data associated with the patient, and determining, using the performance model and based on the personal data and the one or more calibrated measurement parameters, a calibrated output value indicative of the physiological condition.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
81.
INTELLIGENT MEDICATION DELIVERY SYSTEMS AND METHODS FOR DOSE RECOMMENDATION AND MANAGEMENT
Systems, devices, and techniques are disclosed for administering and tracking medicine to patients and providing health management capabilities for patients and caregivers. In some aspects, a method includes receiving one or more analyte values associated with a health condition of the patient user; receiving contextual data associated with the patient user obtained by the mobile computing device, where the obtained contextual data includes information associated with a meal; determining a medicine metric value associated with an amount of medicine active in the body of the patient user; autonomously calculating a dose of the medicine without input from the user based at least on the one or more analyte values, the medicine metric value, and the information associated with a meal; and continuously displaying the calculated dose of the medicine.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 70/40 - ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
This invention pertains to systems and components useful for infusing medications such as insulin. Typically, the components are used to deliver insulin to a diabetic patient at a site of infusion over a period of time greater than 4 days. The system components typically comprise a cannula adapted for subcutaneous insertion into a diabetic patient. The system further comprises a fluid conduit adapted to deliver the insulin solution from a medication reservoir to the site of infusion and a depot in operable contact with the fluid conduit. The depot comprises selected materials including a site-loss mitigating agent (such as heparin) which inhibits inflammation at the site of infusion, and encapsulation of the cannula at the site of infusion. The site-loss mitigating agent is not premixed with the insulin, and instead is adapted to contact the insulin solution in the depot as the insulin solution flows from the medication reservoir to the site of infusion.
A61M 5/38 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
A61K 9/00 - Medicinal preparations characterised by special physical form
A method, and a system configured to perform a method, for customizing user alerts in a medicine administration and tracking system including detecting an alertable condition for which a medicine administration and tracking system is configured to monitor, generating a custom alert for the alertable condition based at least in part on historical data indicating a responsiveness to previous alerts for the same alertable condition, delivering the generated custom alert to a user, determining the user's response to the generated custom alert, and updating the historical data to include the alertable condition, the generated custom alert, and the user's level of responsiveness to the generated custom alert.
Electromechanical actuation systems and related operating methods are provided. A method of controlling an electromechanical actuator in response to an input command signal at an input terminal involves determining a commanded actuation state value based on a characteristic of the input command signal, generating driver command signals based on the commanded actuation state value and an actuator type associated with the electromechanical actuator, and operating driver circuitry in accordance with the driver command signals to provide output signals at output terminals coupled to the electromechanical actuator.
H02P 27/08 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using dc to ac converters or inverters with pulse width modulation
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
H02P 6/08 - Arrangements for controlling the speed or torque of a single motor
H02P 27/06 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using dc to ac converters or inverters
85.
ANALYTE SENSORS AND METHODS FOR FABRICATING ANALYTE SENSORS
Analyte sensors and methods for fabricating analyte sensors in a roll-to-roll process are provided. In an exemplary embodiment, a method includes providing a roll of a polyester substrate having a first side coated with a layer of platinum, wherein the platinum is in direct contact with the polyester substrate; patterning the layer of platinum to form electrodes; punching the polyester substrate to form ribbons, wherein each ribbon is connected to a remaining polyester substrate web by a tab, and wherein each sensor includes an electrode; after punching the polyester substrate to form ribbons, depositing an enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane; after depositing the enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane, singulating the individual sensors by completely separating each individual sensor from the polyester substrate.
A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
87.
SYSTEMS FOR PHYSIOLOGICAL CHARACTERISTIC MONITORING
A physiological characteristic monitoring system includes a wearable attachment device, an electronic device, and a physiological characteristic sensor (e.g., a glucose sensor) including a portion that is insertable into subcutaneous tissue of a user to generate sensor signals indicating a physiological characteristic of the user. The electronic device includes a first connector configured to detachably couple to the physiological characteristic sensor to receive the sensor signals in a first configuration of the electronic device, a second connector configured to detachably couple to the wearable attachment device in a second configuration of the electronic device, a controller configured to determine the physiological characteristic of the user based on the sensor signals, and a display configured to display the physiological characteristic of the user.
This disclosure relates to ingress-tolerant input devices comprising sliders. Aspects of the disclosure relate to an ingress-tolerant switch assembly for operating an electronic device in an ingress-protected manner. The switch assembly is at least partially disposed on an outer surface of an enclosure of the electronic device and generally includes a spring, a magnet coupled to the spring, and a slider coupled to the magnet. A spring force of the spring is overcome by a user moving the slider relative to the enclosure such that the slider moves the magnet into proximity of the magnetic sensor to cause the magnetic sensor to generate a sensor signal for performing a function of the electronic device.
H01H 9/04 - Dustproof, splashproof, drip-proof, waterproof, or flameproof casings
G01D 5/14 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage
A single flex double-sided electrode useful in a continuous glucose monitoring sensor. In one example, a counter electrode is placed on the back-side of the flex and a work electrode is placed on the top-side of the sensor flex. The electrode is fabricated on physical vapor deposited metal deposited on a base substrate. Adhesion of the electrode to the base substrate is carefully controlled so that the electrode can be processed on the substrate and subsequently removed from the substrate after processing.
Techniques disclosed herein relate generally to notification generation in a medical device system. In some embodiments, the techniques involve generating a first notification via a medical application executing on a first device, determining that the first notification was not acknowledged within a predetermined time frame, and causing generation of a second notification at a medical device carried by a user to notify the user that the first notification has not been acknowledged.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
G06F 11/14 - Error detection or correction of the data by redundancy in operation, e.g. by using different operation sequences leading to the same result
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
91.
Personalized parameter modeling methods and related devices and systems
A processor-implemented method comprises obtaining current operational context information associated with a sensing device; obtaining an expected calibration factor parameter model associated with a patient; calculating an expected calibration factor value based on the expected calibration factor parameter model and the current operational context information; obtaining one or more electrical signals from the sensing device, the one or more electrical signals having a signal characteristic indicative of a physiological condition; converting the one or more electrical signals into a calibrated measurement value for the physiological condition using the expected calibration factor value; and outputting the calibrated measurement value for the physiological condition.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A medical device includes a first housing portion (FHP) and a second housing portion (SHP) configured to be to be movable relative to each other from a first position to operatively engage at a second position to couple at least one of a drive device and a needle-inserting device supported by one of the FHP and the SHP to a reservoir supported by the other of the FHP and the SHP. Electronic circuitry configured to detect at least one of a first magnetic interaction between a magnet and at least one of a first magnetically attractive material and a first magnet-responsive device and a second magnetic interaction between the magnet and at least one of a second magnetically attractive material and a second magnet-responsive device, and to provide a signal or a change in state in response to detecting at least one of the interactions.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61M 5/14 - Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
An embodiment of a sensor device includes a base substrate, a circuit pattern formed overlying the interior surface of the substrate, a physiological characteristic sensor element on the exterior surface of the substrate, conductive plug elements located in vias formed through the substrate, each conductive plug element having one end coupled to a sensor electrode, and having another end coupled to the circuit pattern, a multilayer component stack carried on the substrate and connected to the circuit pattern, the stack including features and components to provide processing and wireless communication functionality for sensor data obtained in association with operation of the sensor device, and an enclosure structure coupled to the substrate to enclose the interior surface of the substrate, the circuit pattern, and the stack.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H01L 21/48 - Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the groups
H01L 21/52 - Mounting semiconductor bodies in containers
H01L 21/78 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices
H01L 23/055 - Containers; Seals characterised by the shape the container being a hollow construction and having an insulating base as a mounting for the semiconductor body the leads having a passage through the base
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
94.
SYSTEMS AND METHODS FOR DETERMINING THE CONDITION OF MEDICINE FOR USE IN MEDICINE ADMINISTRATION SYSTEMS
A medicine administration system includes a medicine administration device, a medicine cartridge receivable with the medicine administration device, and a contrast background. The medicine cartridge is configured to retain medicine therein. The medicine administration device is configured to dispense at least some of the medicine through a dispensing end of the medicine cartridge. The contrast background is positioned relative to the medicine cartridge to permit visualization of the contrast background through the medicine within the medicine cartridge. The contrast background is configured to facilitate image processing of a captured image of the contrast background through the medicine within the medicine cartridge to determine a condition of the medicine within the medicine cartridge.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A hub member for an infusion set device includes a body and pads configured to receive a squeezing force directed radially inward relative to an axis of the body. The body compresses radially inward relative to the axis in response to the squeezing force. A plurality of connection features on the body are moveable from a first position radially inward toward a second position when the hub member is compressed radially inward. The connection features engage one or more further connection features on a housing to attach the hub member to the housing when the connection features are in the first position, and disengage the further connection features to release the hub member when the connection features are moved toward the second position.
An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.
This disclosure includes an apparatus for detecting mating of a cap with a fluid delivery device having a housing, a receptacle, and a sensor. The housing is configured to carry an insulin delivery device having a reservoir of the fluid. The receptacle is provided by the housing having a coupling with a locking recess configured to receive a cap with a sprung locking arm. The pressure sensor is carried by the receptacle proximate the coupling and configured to detect engagement force of the sprung locking arm with the receptacle when mated with the housing. A method is also provided.
This disclosure relates to ingress-tolerant input devices. Aspects of the disclosure relate to an ingress-tolerant switch assembly for operating an electronic device in an ingress-protected manner. The switch assembly includes a button configured to be coupled to an outer surface of an enclosure of the electronic device. The switch assembly also includes a spring operably coupled to the button and a magnet coupled to the spring. A pressing force applied by a user to the button overcomes a spring force of the spring to move the magnet into proximity of the magnetic sensor to cause the magnetic sensor to generate a sensor signal for performing a function of the electronic device.
H01H 9/04 - Dustproof, splashproof, drip-proof, waterproof, or flameproof casings
H01H 1/54 - Means for increasing contact pressure, preventing vibration of contacts, holding contacts together after engagement, or biasing contacts to the open position by magnetic force
A method of testing one or more analyte sensors each comprising a first electrode; a second electrode; and a material layer disposed on or above the first electrode; the method including (a) applying a voltage potential to the first electrode with respect to the second electrode; (b) measuring a test signal comprising an output current from the first electrode that results from the application of the voltage potential; (c) using the test signal from (b) to observe an electrical characteristic of the analyte sensor; and (d) correlating the electrical characteristic a parameter associated with an electrochemical response of the analyte sensor to an analyte, wherein the testing is under dry conditions without exposure of the electrodes to a fluid containing the analyte or an in-vivo environment containing the analyte.
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
100.
USER-MOUNTABLE ELECTRONIC DEVICE WITH DEPLOYMENT GUIDANCE FEATURES
The disclosed system includes a user-mountable electronic device, an output interface, and at least one processor. The electronic device includes a housing and at least one sensor device located within the housing and configured to generate sensor output that indicates orientation or motion of the user-mountable electronic device. The at least one processor is operated to: receive the sensor output; identify, based on the received sensor output, a body part on which the user intends to deploy the user-mountable electronic device; determine a preferred orientation of the user-mountable electronic device relative to the identified body part; and cause the output interface to provide deployment guidance that indicates the preferred orientation of the user-mountable electronic device.
patents
