A wireless pressure sensing unit (20) comprises a membrane (25) forming an outer wall portion of a cavity and two permanent magnets (26,28) inside the cavity. One magnet is coupled to the membrane, and at least one magnet is free to oscillate with a rotational movement. At least one is free to oscillate with a rotational movement. The oscillation takes place at a resonance frequency, which is a function of the sensed pressure, which pressure influences the spacing between the two permanent magnets. This oscillation frequency can be sensed remotely by measuring a magnetic field altered by the oscillation. The wireless pressure sensing unit may be provided on a catheter (21) or guidewire.
The present invention proposes an apparatus and method for estimating a level of thermal ablation. The apparatus (110) comprises a data interface (111) configured to receive the three-dimensional ultrasound echo data of the tissue region; and a data processor (113) configured to measure in-plane strain and out-of-plane motion regarding the tissue region on basis of the received ultrasound echo data. The data processor (113) is further configured to estimate the level of tissue ablation for the tissue region on basis of the in-plane strain, the out-of-plane motion, and a predetermined model, and the predetermined model at least reflecting a first causal relationship between the in-plane strain and the level of tissue ablation and a second causal relationship between the out-of-plane motion and the level of tissue ablation. While the out-of-plane motion is merely regarded as artifacts to be compensated, the present invention makes use of the causal relationship between the level of tissue ablation and the out-of-plane motion, and thus the estimation is more accurate and/or reliable.
A controller for registering a magnetic resonance imaging (MRI) image to a tracking space includes a memory that stores instructions; and a processor that executes the instructions. The instructions cause the controller to execute a process that results in generating an image registration of a 3-dimensional magnetic resonance imaging volume in the tracking space based on 2- dimensional coordinates of a midsagittal plane of an organ, an image registration of the midsagittal plane of the organ, and a tracking position in the tracking space of an ultrasound image of the midsagittal plane.
A system (200) comprising a light source (220) configured to generate light source radiation (221), wherein the light source radiation (221) at least comprises UV radiation, wherein the system (200) further comprises a luminescent material (400) configured to convert part of the light source radiation (221) into luminescent material radiation (401), wherein the luminescent material radiation (401) comprises one or more of visible light and infrared radiation, wherein the system (200) is configured to generate system light (201) comprising the light source radiation (221) and the luminescent material radiation (401).
B08B 7/00 - Cleaning by methods not provided for in a single other subclass or a single group in this subclass
F21K 9/64 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction using wavelength conversion means distinct or spaced from the light-generating element, e.g. a remote phosphor layer
F21V 9/30 - Elements containing photoluminescent material distinct from or spaced from the light source
F21V 9/32 - Elements containing photoluminescent material distinct from or spaced from the light source characterised by the arrangement of the photoluminescent material
Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of two biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Pyruvate Kinase (PK) and at least one of Matrix metalloproteinase-9 (MMP9), S100 calcium-binding protein A8 (S100A8), and Hemoglobin subunit beta (Hb-beta); or of the proteins Matrix metalloproteinase-9 (MMP9) and at least one of S 100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in said patient.
Disclosed is an in vitro method for assessing whether a human patient has periodontitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the Free Light Chain ? protein and/or the Free Light Chain ?. Based on the concentration(s) as measured, a value is determined reflecting the concentration or joint concentrations for said protein or proteins. This value is compared with a threshold value reflecting in the same manner the concentration or joint concentrations associated with periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of periodontitis in said patient. Thereby, typically, a testing value reflecting a concentration or joint concentration below the concentration or joint concentration reflected by the threshold value is indicative for absence of periodontitis in said patient, and a testing value reflecting a concentration or joint concentration at or above the concentration or joint concentration reflected by the threshold value, is indicative for periodontitis in said patient.
An apparatus for generating view images for a scene comprises a store (101) which stores three dimensional scene data representing the scene from a viewing region. The three dimensional scene data may e.g. be images and depth maps captured from capture positions within the viewing region. A movement processor (105) receives motion data, such as head or eye tracking data, for a user and determines an observer viewing position and an observer viewing orientation from the motion data. A change processor (109) determines an orientation change measure for the observer viewing orientation and an adapter (111) is arranged to reduce a distance from the observer viewing position relative to the viewing region in response to the orientation change measure. An image generator (103) generates view images for the observer viewing position and the observer viewing orientation from the scene data.
An electric current supply system (20) is designed to be at least partially submerged in an electrically conductive liquid during operation thereof, and comprises at least one electrically conductive component (21, 22, 23, 24) enveloped in liquid- tight material (40). The component (21, 22, 23, 24) comprises sacrificial material that is capable of reacting electrochemically with the liquid. Further, the component (21, 22, 23, 24) comprises at least one gas trap portion (50) at which the sacrificial material occupies a space in the liquid-tight material (40) that is thereby defined with a gas trapping shape. If, in case of damage to the system (20) in an actual submerged state thereof, the component (21, 22, 23, 24) gets exposed to the liquid, it is achieved that an electrochemical reaction occurring at the exposed area of the component (21, 22, 23, 24) and an outflow of electric current to the liquid are stopped.
H02G 1/10 - Methods or apparatus specially adapted for installing, maintaining, repairing, or dismantling electric cables or lines for laying cables, e.g. laying apparatus on vehicle in or under water
In one embodiment, an apparatus (12) is presented that detects wireless signals from external devices (18) that uniquely identify each of the external devices, records, in memory (30), information about the external devices without access to an external database, and compares information from the external devices to determine a relative location of the wearable device without using additional, power-hungry position location functionality if there is a threshold match in the compared information. In some embodiments, the invention uses the determined relative location to trigger an action at another device. The invention, using self-contained functionality, enables improvements in same location or home location determination accuracy, memory conservation, and power consumption.
G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinations; Position-fixing by co-ordinating two or more distance determinations using radio waves
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G08B 21/02 - Alarms for ensuring the safety of persons
G08B 25/01 - Alarm systems in which the location of the alarm condition is signalled to a central station, e.g. fire or police telegraphic systems characterised by the transmission medium
10.
ASSESSMENT OF NOTCH CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
The present invention relates to a computer-implemented method for inferring activity of a Notch cellular signaling pathway in a subject based on expression levels of three or more target genes of the Notch cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a Notch cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the Notch cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a Notch cellular signaling pathway in a subject, and to the use of such kits in performing the method.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
11.
DETERMINING FUNCTIONAL STATUS OF IMMUNE CELLS TYPES AND IMMUNE RESPONSE
A method for determining functional status of at least one immune cell type in at least one sample of a subject comprises determining the functional status of the at least one immune cell type based on activity of at least one signaling pathway in the at least one immune cell type in the at least one sample of the subject; and optionally providing the functional status of the at least one immune cell type in the at least one sample of the subject.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
12.
ASSESSMENT OF JAK-STAT1/2 CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a JAK- STAT1/2 cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject, and to the use of such kits in performing the method.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
13.
A LIGHT EMITTING DEVICE, COMPRISING LIGHT EMITTING UNITS BEING ARRANGED IN A PLANE FILLING PATTERN
A light emitting device (1) is provided that can be used in various contexts, including the context of realizing an anti-fouling action on surfaces. The light emitting device (1) comprises light emitting units (10) being arranged in a plane filling pattern (20) for covering at least a substantial portion of a surface. Individual light emitting units (10) are electrically interconnected through connection areas (12, 13) as present on the light emitting units (10) for providing electrical access to an internal electrical circuit (11) thereof, wherein the light emitting units (10) overlap at the positions of at least portions of the connection areas (12, 13) thereof. Further, it may be so that at least one of the connection areas (12, 13) of the individual light emitting units (10) is electrically connected simultaneously to respective connection areas (12, 13) of at least two other light emitting units (10).
A material for binding to a cell culturing protein is disclosed. The material contains a bulk-modified elastomer comprising a plurality of fatty acid moieties covalently bound to the elastomer bulk, wherein the carboxylic acid groups of said moieties are available to provide said binding. Also disclosed are a fluidic device module, a cell culturing scaffold, a fluidic device, the method of synthesizing such a material and a drug testing method. With such a material, a (monolithic) fluidic device module may be manufactured in as few as a single step injection molding process.
The invention provides a layer stack (500) comprising a first silicone layer (510), wherein the first silicone layer (510) has a first surface (511) and a second surface (512), wherein the first silicone layer (510) is transmissive for UV radiation having one or more wavelengths selected from the range of 200-380 nm, wherein the layer stack (500) further comprises one or more of: - a first layer element configured at a first side of the first surface (511), wherein the first layer element is associated by a chemical binding with the first surface (511) directly or via a first intermediate layer, which is transmissive for UV radiation having one or more wavelengths selected from the range of 200-380 nm, wherein the first layer element at least comprises a first layer differing in composition from the first silicone layer (510), and wherein the first layer element is transmissive for UV radiation having one or more wavelengths selected from the range of 200-380 nm; and - a second layer element (620) configured at a second side of the second surface (512) wherein the second layer element (620) is associated by a chemical binding with the second surface (512) directly or via a second intermediate layer, wherein the second layer element (620) at least comprises a second layer (1220) differing in composition from the first silicone layer (510).
Disclosed is an in vitro method for assessing whether a human subject has periodontitis. The method comprises detecting, in a sample of saliva from said subject, the concentrations of the proteins Hepatocyte Growth Factor (HGF) and Matrix Metalloproteinase 8 (MMP-8). Based on the concentrations determined, and adding age, and possibly other demographic markers such as sex and/or BMI, a testing value reflecting the joint concentrations is determined for said proteins, in combination with one or more demographic markers. The testing value is compared with a threshold value. The threshold reflects in the same manner the joint concentrations and the age, and possibly other demographic markers, as associated with periodontitis and may be seen as an upper limit of testing values as seen in a population of subjects without periodontitis. Thereby a testing value at or above the threshold value is indicative for periodontitis in said subject.
Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Interleukin-1.beta. (IL-1.beta.), Matrix metalloproteinase-9 (MMP-9) and at least one of the proteins: Interleukin-6 (IL-6), and Matrix metalloproteinase-3 (MMP-3). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in said patient.
The invention provides an system (200) comprising (i) a light source (220) configured to provide radiation (221), wherein the radiation (221) at least comprises UV radiation, (ii) a waveguide element (1210) comprising a radiation exit window (230), wherein the waveguide element (1210) is configured to receive at least part of the radiation (221) and to radiate at least part of the radiation (221) to the exterior of the waveguide element (1210) via the radiation exit window (230) and configured to internally reflect part of the radiation (221) at the radiation exit window (230), (iii) an optical sensor (310) configured to sense an internal reflection intensity (I) of the internally reflected radiation (221), and (iv) a control system (300), functionally coupled to the optical sensor, and configured to reduce the intensity of the radiation (221) as function of reaching a predetermined first threshold of a reduction of the internal reflection intensity (I) over a time.
The present invention relates to detecting objects in medical images. In order to provide an improved detection of objects in medical images, a medical image detection device (10) is provided that comprises an image data input (12) and a processing unit (14). The image data input is configured to receive image data of a biological sample. The processing unit comprises a detector (16) and a classifier (18). The detector is configured to detect objects of interest in the sample by a detection in the image data of at least one predetermined object feature. The detected objects being candidate objects, wherein the candidate objects comprise true positives and possible false positives. Further, the classifier is configured to classify the possible false positives as false positives or as true positives. The classifier is a trained classifier, trained specifically to recognize the false positives of the detector.
A multi-view display device (1) is switchable between a single view and a multiple view mode. The display device comprises a display panel (3) having rows and columns of pixels or sub-pixels (5) configured to produce a display output. A lenticular lens arrangement (9) is arranged over a display output side of the display panel and includes an array of lenticular lens elements (11) which comprise an electro-optic material (23) adjacent a non-switchable optically transparent layer (21). The electro-optic material comprises a cholesteric liquid crystal component having an ordinary refractive index and an extra- ordinary refractive index. The cholesteric liquid crystal component comprises a helical structure defined by a pitch which is selected such that a product of the pitch and the difference between the ordinary and extra-ordinary refractive indices is equal to or less than a visible light wavelength of the display output. An effective refractive index of the cholesteric liquid crystal component is controllable by application of an electrical stimulus thereby permitting switching between the single view and multiple view modes.
G02F 1/13 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
G02B 27/22 - Other optical systems; Other optical apparatus for producing stereoscopic or other three-dimensional effects
G02F 1/137 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering
A first electronic network node (110) is provided configured for a key exchange (KEX) protocol, the first network node is configured to - obtain a shared matrix (A) shared with a second network node, entries in the shared matrix A being selected modulo a first modulus q, generate a private key matrix (S I ), entries in the private key matrix being bounded in absolute value by a bound (s) generate a public key matrix (P I ) by computing a matrix product between the shared matrix (A) and the private key matrix (S I ) modulo the first modulus (q) and scaling the entries in the matrix product down to a second modulus (p).
Van Strijp, Dianne Arnoldina Margaretha Wilhelmina
Van Brussel, Anne Godefrida Catharina
Wrobel, Janneke
Van Zon, Joannes Baptist Adrianus Dionisius
Den Biezen, Eveline Catharina Anna Clasina
Alves De Inda, Marcia
Abstract
Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.
The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relates to methods for inferring an oxidative stress state of a FOXO transcription element and for inferring the activity of the FOXO/PI3K cellular signalling pathway based on expression levels of the target genes as well as products to perform the methods.
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
A first device and a second device are disclosed for reaching agreement on a secret value. Herein, the second device comprises a receiver configured to receive information indicative of a reconciliation data h from the first device, a processor configured to compute a common secret s based on an integer value b, an equation, and system parameters. The processor is configured to compute b based on a key exchange protocol. The first device has a number a in approximate agreement with the number b. The first device comprises a processor configured to determine a common secret s based on an integer value a an equation, and system parameters, and determine a reconciliation data h. The first device further comprises a transmitter configured to transmit information indicative of the reconciliation data h to the second device.
According to an aspect, there is provided a computer-implemented method of determining a fall risk of a subject, the method comprising receiving a first data set indicative of movement of the subject; receiving a second data set indicative of context information of the subject; selecting a part of the first data set based on the second data set; and determining a fall risk based on the selected part of the first data set.
A light emitting arrangement (100) for anti-fouling of a surface (30), comprises an optical medium (10) and at least one light source (20) for emitting anti-fouling light. A first zone (1) of the arrangement (100), which is closest to the light source (20), is arranged and configured to predominantly make the anti-fouling light reflect in a specular manner towards an emission surface (12) of the optical medium (10), through the optical medium (10), a second zone (2) of the arrangement (100) is arranged and configured to predominantly realize propagation of the anti-fouling light through the optical medium (10) by total internal reflection, and a third zone (3) of the arrangement (100), which is furthest away from the light source (20), is arranged and configured to predominantly make the anti- fouling light scatter out of the optical medium (10), through the emission surface (12) of the optical medium (10).
The invention provides a light guide element (1300) comprising a light guide (300), wherein the light guide (300) comprises a first light guide face (301) and a second light guide face (302) with UV radiation transmissive light guide material (305) between the first light guide face (301) and the second light guide face (302), wherein the light guide element (1300) further comprises one or more of: (i) a first layer element (30) in contact with the first light guide face (301), wherein the first layer element (30) is transmissive for UV radiation; and (ii) a second layer element (130) in contact with the second light guide face (301), wherein the second layer element (130) has one or more functionalities selected from the group consisting of (a) reflective for UV radiation, (b) adhesive for adhering the light guide (300) to an object, (c) reinforcing the light guide element (1300), and (d) protective for the light guide (300).
F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
G02B 6/10 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
28.
LIGHT GUIDES WITH LOW REFRACTIVE COATING TO BE USED IN WATER
The invention provides a light guide element (1300) comprising a light guide (300) and a layer element (30), wherein the light guide (300) comprises a light guide face (301) and wherein the layer element (30) comprises an optical layer (310), wherein said optical layer (310) is in contact with at least part of the light guide face (301), wherein the optical layer (310) has a first index of refraction (n1) smaller than 1.36 at 280 nm, wherein the light guide (300) comprises a UV radiation transmissive light guide material (305).
F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
G02B 6/10 - Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
A system and method are provided for change detection in medical images. A difference image representing intensity differences between a first medical image and a second medical image is generated. A mixture model is fitted to an intensity distribution of the difference image to identify a plurality of probability distributions which collectively model the intensity distribution. A plurality of intensity ranges is determined as a function of the plurality of probability distributions. Image data of the difference image is labeled by determining into which of the plurality of intensity ranges said labeled image data falls. Accordingly, more accurate change detection is obtained than known systems and method.
Various embodiments described herein relate to a method, system, and non- transitory machine-readable storage medium for determining an opportune time for user interaction including one or more of the following: the method comprising: receiving a request from a client application for an indication of whether a user is open to participate in a user interaction; obtaining usage information regarding the user's recent activity on a user device; applying at least one trained predictive model to the usage information to identify the user's current contextual state, wherein the current contextual state includes at least one of: an availability measure representative of the user's current ability to perform a physical action associated with the user interaction, and a receptiveness measure representative of the user's current ability to pay attention to the user interaction; determining an opportunity indication based on the user's contextual state; and providing the opportunity indication to the client application.
Van Den Dungen, Wilhelmus Andreas Marinus Arnoldus Maria
Ledingham, Stephen
Russ, Tomas
Box, Wilhelmus Josephus
Abstract
A geo-fencing system (102) includes a base device (104) configured to create a virtual fence (108) around the base devise that bounds a safe zone (110). The geo-fencing system further includes a wearable device (106) initially located within the safe zone. The geo-fencing system further includes a processor configured to execute a dynamic adaptive control algorithm that computes at least one operating parameter for at least one of the base device and the wearable device based on a dynamic and adaptive combination of different signals indicative of distance measurements between the wearable device and the base device computed by the at least one of the base device and the wearable device. The processor conveys the at least one operating parameter to the at least one of the base device and the wearable device, which employs the at least one operating parameter for operation and determination of subsequent distance measurements.
As the capabilities of digital histopathology machines grows, there is an increasing need to ease the burden on pathology professionals of finding interesting structures in such images. Digital histopathology images can be at least several Gigabytes in size, and they may contain millions of cell structures of interest. Automated algorithms for finding structures in such images have been proposed, such as the Active Contour Model (ACM). The ACM algorithm can have difficulty detecting regions in images having variable colour or texture distributions. Such regions are often found in images containing cell nuclei, because nuclei do not always have a homogeneous appearance. The present application describes a technique to identify inhomogeneous structures, for example, cell nuclei, in digital histopathology information. It is proposed to search pre-computed super-pixel information using a morphological variable, such as a shape- compactness metric, to identify candidate objects.
The present system is configured to track informal observations by multiple caregivers about a care recipient and provide actionable feedback to the multiple caregivers for managing health of the care recipient based on the informal observations. Informal caregivers are constantly observing the health and/or wellness of care recipients they provide care for. Within families for example, multiple informal caregivers coordinate the care they provide for a care recipient amongst each other to balance the workload. These caregivers observe the same care recipient often on different occasions, from different perspectives, and with varying levels of subjectivity. Keeping an eye out for abnormal behavior by the care recipient, changes in capabilities of the care recipient, and/or potential disease progression, for example, are pieces of data caregivers commonly observe in an informal, rarely structured way.
G16H 40/00 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
34.
A STEAM IRON WITH A COLLECTION COMPARTMENT FOR CALCIFIED DEPOSITS
The present application relates to steam iron (10) comprising a soleplate (12), a discharge element (14), a retaining member (16) and a collection compartment (17). The soleplate (12) comprises a steam chamber (13) for generating steam. The steam chamber (13) comprising an opening (13A) arranged at a rear end (R) of the soleplate (12). The discharge element (14) extends from the opening (13A). The collection compartment (17) is formed in the discharge element (14) for collecting calcified deposits (S) formed in the steam chamber (13). The retaining member (16) is arranged in the discharge element (14). T retaining member (16) extends over a front end portion (P1) of the collection compartment (17) to retain the calcified deposits (S) in the collection compartment (17). This invention prevents the calcified deposits from escaping from the collection compartment when the steam iron is tilted.
D06F 75/14 - Hand irons internally heated by electricity with means for supplying steam to the article being ironed the steam being produced from water in a reservoir carried by the iron
The present invention relates to a device for detecting muscle seizure of a subject in a comfortable, non-invasive manner and user-friendly manner. The device comprises an activity input configured to obtain activity information related to a subject's activity when using a user device; a gaze input configured to obtain gaze information related to the subject's gaze when using the user device; a detection unit configured to detect a muscle seizure of the subject when using the user device by determining if the activity information indicates a reduction in the subject's activity using a user device and if the gaze information indicates that the subject's gaze is directed to the user device; and a control unit configured to generate a control signal, if the detection unit detects a muscle seizure of the subject configured to control a vibration unit attached to the subject and/or the user device to vibrate.
There is provided a method of monitoring a subject, the method comprising obtaining measurements of the movements of the subject over time; obtaining measurements of the skin temperature of the subject over time; and processing the obtained measurements of the movements and the obtained measurements of the skin temperature to identify a urination event of the subject. An apparatus for monitoring a subject is also provided.
An assembly (2) comprising at least two elements (10, 24) in a movable arrangement relative to each other for performing a first function of the assembly (2) is furthermore equipped with an anti-biofouling system (30) for subjecting at least an area (11) of the assembly (2) to be at least partially exposed to water during at least a part of its lifetime to an anti-biofouling action as an additional function of the assembly (2), different from the first function of the assembly (2). The anti-biofouling system (30) comprises one or more light sources (32) for emitting anti-biofouling light, and the anti-biofouling system (30) is adapted to realize coverage of the area (11) with the anti-biofouling light on the basis of the movable arrangement of the at least two elements (10, 24) relative to each other for performing the first function of the assembly (2).
In an assembly of a buoyancy module (10) and an anti-fouling system, the buoyancy module (10) is adapted to floatingly support a functional device (40) in an underwater environment. In particular, the anti-fouling system comprises at least one anti- fouling appliance (23, 24) for performing an anti-fouling action on at least a portion of the exterior surface (16) of the buoyancy module (10), wherein the anti-fouling appliance (23, 24) has an exterior arrangement with respect to the buoyancy module (10) while being mechanically coupled to the buoyancy module (10) and/or being adapted for mechanical coupling to a functional device (40), and/or is arranged on the exterior surface (16) of the buoyancy module (10), and/or is arranged in the interior of the buoyancy module (10). In a practical embodiment, the anti-fouling appliance comprises an ultraviolet light source (23) and possibly also a light guide (24) coupled to the ultraviolet light source (23).
A lanyard device (10) having a flexible neck cord (12) and at least one strain sensor (30) arranged for sensing strain in the flexible neck cord; and a personal lanyard monitoring system including the lanyard device (10). A position recognition unit (52) is configured for comparing strain data obtained from the at least one strain sensor (30) to predetermined strain data, and recognizing a position of the flexible neck cord (12) in dependence on a result of the comparison.
In an assembly (2) of an instrument panel (10) and an anti-fouling system (20), the instrument panel (10) is designed for arrangement on a subsea structure, particularly a subsea tree comprising at least one instrument which is to be inspected and/or manipulated underwater, particularly by means of a remotely operated underwater vehicle, and the anti-fouling system (20) comprises at least one anti-fouling appliance (22, 23) for performing an anti-fouling action on at least a portion of the exterior surface (15) of the instrument panel (10). The anti-fouling appliance (22, 23) may have at least one of various possible arrangements with respect to the instrument panel (10), including an exterior arrangement and an interior arrangement, and an arrangement on the exterior surface (15) of the instrument panel (10). The anti-fouling appliance (22, 23) may comprise an ultraviolet light source (22) and possibly also a light guide (23).
E21B 47/01 - Devices for supporting measuring instruments on drill bits, pipes, rods or wirelines; Protecting measuring instruments in boreholes against heat, shock, pressure or the like
An occupancy detection system uses at least two sensors which are mounted spaced apart in an area to be monitored. A test metric is formed which based on a combination of distances for the at least two sensors. The evolution of the test metric over time enables determination of whether there is a single occupant or multiple occupants in the area to be monitored.
G08B 13/191 - Actuation by interference with heat, light, or radiation of shorter wavelength; Actuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using infra-red-radiation detection systems using pyroelectric sensor means
42.
A DEVICE HAVING SURFACES AND AN ANTI-BIOFOULING SYSTEM COMPRISING AT LEAST ONE ANTI-BIOFOULING LIGHT SOURCE FOR EMITTING RAYS OF ANTI-BIOFOULING LIGHT
A device (100) has surfaces (21, 22, 23, 24) and an anti-biofouling system (10) comprising at least one light source (11, 12) for performing an anti-biofouling action on at least a majority of the surfaces, the at least one light source (11, 12) being adapted to emit rays of anti-biofouling light. The surfaces (21, 22, 23, 24) are configured relative to each other and to the at least one light source (11, 12) such that during operation of the at least one light source, at least a majority of the surfaces (21, 22, 23, 24) is free from shadow with respect to the rays of anti-biofouling light from the at least one light source (11, 12), wherein it may be possible for the rays of anti- biofouling light to reach the surfaces (21, 22, 23, 24) by skimming along the surfaces (21, 22, 23, 24).
The present invention relates to a load arrangement (400) for use in an electrical power arrangement (200) and for getting arranged at a first external electrically conductive element (50). The load arrangement comprises a load (20) having a first load terminal (2a) and a second load terminal (2b) for being powered by an AC power source (1), a first electrode (3) electrically connected to the first load terminal (2a), and a dielectric layer (4). The first electrode (3) and the dielectric layer (4) are arranged to form, in combination with a first external electrically conductive element (50) representing an outer surface of a marine structure, a capacitor (6) for capacitive transmission of electrical power between the first electrode (3) and the first external element (50). At least one of the capacitor (6) and the second load terminal (2b) is arranged for electrical power transmission through water (10) to form an electrical path via the water (10) between the AC power source (1) and the respective one of the capacitor and the second load terminal (2b). The first load terminal (2a) is electrically insulated from the second load terminal (2b).
An apparatus comprises a depth map source (109) providing a depth map for an image and a confidence map source (111) providing a confidence map with confidence values for pixels of the depth map. The confidence values designate the pixels as confident or non-confident pixels reflecting whether the depth value meets a reliability criterion or not. A depth modifier (113) performs a depth modification operation which modifies depth values for pixels of the depth map. A modified depth value for a first pixel is determined as a current depth value for the first pixel if this is designated as a confident pixel or if there are no confident pixels within a neighborhood set of pixels, and otherwise the modified value is determined as the maximum of the current depth value and a depth value determined as a function of depth values of pixels within the neighborhood set being designated as confident pixels.
The present invention relates to a load arrangement for use in an electrical power arrangement and for arrangement at a first external electrically conductive element (5). The load arrangement comprises a load (2), a first electrode (3) electrically connected to the load (2), a dielectric layer (4) and a carrier carrying the load (2), the first electrode (3) and the dielectric layer (4). The load (2), the first electrode (3) and the dielectric layer (4) form a structure, which is configured for being arranged at the first external electrically conductive element (5). The first electrode (3) and the dielectric layer (4) are arranged to form, in combination with a first external electrically conductive element (5) representing an outer surface of a marine structure, a capacitor (6) for capacitive transmission of electrical power between the first electrode (3) and the first external element (5). The carrier is configured for being arranged at the first external electrically conductive element (5). The load (2) is connected to a second electrode (7) electrically insulated from the first electrode (3) or is arranged for being electrically connected to a second external electrically conductive element (10, 11) electrically insulated from the first electrode (3).
The present invention relates to a marine structure comprising an external surface (50), a load (2, 20, 21, 22, 25) comprising a light source, said load having a first load terminal (2a) and a second load terminal (2b) adapted to be powered by an AC power source (1), said AC power source (1) having a first AC terminal (1a) electrically connectable to the surface (50) and a second AC terminal (1b), a first electrode (3) electrically connected to the first load terminal (2a), and a dielectric layer (4). The first electrode (3) and the dielectric layer (4) are arranged to form, in combination with the surface (50), a capacitor (6) for capacitive transmission of electrical power between the first electrode (3) and the surface (50). The second AC terminal (1b) and the second load terminal (2b) are arranged to be electrically connected to an external electrically conductive element (10, 11) insulated from the surface (50). The first load terminal (2a) is electrically insulated from the second load terminal (2b).
A method and system for processing a 3D tissue sample is provided, comprising the steps of receiving a tube with an inner space and two open ends, wherein the tube is configured to retain the 3D tissue sample in the inner space, arranging the tube so that one of the two open ends of the tube is located at a fluid channel, and forcing or actively pressing a tissue processing agent through the fluid channel and into the tube so that the tissue processing agent passes through the tissue.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
There is provided a method and apparatus for calibrating measurements made using a medical monitoring device. A conversion factor may be obtained including a first cross correlation that describes the correlation between measurements made using a first medical monitoring device and measurements made using a second medical monitoring device. The first conversion factor may then be used to convert measurements from the first medical monitoring device onto the same scale as measurements from the second medical monitoring device.
A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.
Van Den Dungen, Wilhelmus Andreas Marinus Arnoldus Maria
Abstract
The present invention relates to a system for position detection, implementing RF-based distance measurement, the system comprising at least one transmitting unit (12) arranged for transmitting an electromagnetic wave signal in the RF range, at least one receiving unit (14) arranged for receiving an electromagnetic wave signal in the RF range, wherein the transmitting unit (12) is arranged to transmit an electromagnetic wave signal specifically formed for distance measurement, and wherein the receiving unit (14) is arranged to receive the electromagnetic wave signal transmitted by the transmitting unit (12) in a direct or mediate fashion, at least one control device (30) for distance measurement based on transmitted signal information and received signal information, the control device (30) further comprising a distance measurement quality assessment unit (32), and a power consumption optimizing unit (34), wherein the distance measurement quality assessment unit (32) is arranged to derive a distance measurement quality indicator, based on distance measurement results, and wherein the power consumption optimizing unit (34) is arranged to adapt at least one transmitting parameter, based on the quality indicator.
A display device has a display panel (70) and a color filter layer (72) spaced from the display panel, comprising an array of color filter portions. In a privacy mode (narrow viewing angle mode), the display panel produces output regions of different light output color, which regions are aligned with corresponding color portions of the color filter layer. In a public mode (wide viewing angle mode) the display panel produces light containing all of the output colors to all of the output regions. By providing a color filter layer spaced from the display panel, color filtering is used to control the range of angles over which an image is output. The color filter layer is in essence moved away from the display panel. The spacing between the two and the width of the color filter portions determines the extent by which the light output is angularly limited.
G09F 9/00 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements
H04N 13/305 - Image reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using lenticular lenses, e.g. arrangements of cylindrical lenses
H04N 13/359 - Switching between monoscopic and stereoscopic modes
G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
G09G 3/00 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes
A system (100) for context aware medical recommendations includes a recommendation engine (138)and a user interface (122). The recommendation engine (138) identifies at least one suggested recommendation (140) according to a medical guideline and context in response to a first input indicating a finding (150) in a medical image (112) of a patient. The user interface (122) displays on a display device (120) the at least one suggested recommendation selectable as a second input.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
53.
GENERATION OF TRIANGLE MESH FOR A THREE DIMENSIONAL IMAGE
An apparatus is arranged to generate a triangle mesh for a three dimensional image. The apparatus includes a depth map source (101) which provides a depth map and a tree generator (105) generates a k-D tree from the depth map. The k-D tree representing a hierarchical arrangement of regions of the depth map satisfying a requirement that a depth variation measure for undivided regions is below a threshold. A triangle mesh generator (107) positions an internal vertex within each region of the k-D tree. The triangle mesh is then generated by forming sides of triangles of the triangle mesh as lines between internal vertices of neighboring regions. The approach may generate an improved triangle mesh that is suitable for many 3D video processing algorithms.
The present invention relates to a wearable device for obtaining signals from a subject for use in the monitoring of pulse-related information of the subject. To enable the use of such a device in the monitoring of pulse-related information of the subject, which provides for unobtrusive, reproducible, easy to use, and simple measurements, the device comprises a device body (20), a PPG signal sensing unit (21) for acquiring a first photoplethysmography, PPG, signal from a first body location of the subject's body, and an imaging unit (22) for acquiring a sequence of images from a second body location of the subject's body different from the first body location, said sequence of images being configured for deriving a second PPG signal for the second body location of the subject's body. Said PPG signal sensing unit and said imaging unit are mounted in or at the device body and are configured to simultaneously acquire the first PPG signal and the sequence of images.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
55.
ASSESSMENT OF NFKB CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
The present invention relates to a method comprising inferring activity of an NFkB cellular signaling pathway based at least on expression levels of six or more target genes of the NFkB cellular signaling pathway measured in a sample. The present invention further relates to an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. The present invention further relates to kits for measuring expression levels.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G06F 19/12 - for modelling or simulation in systems biology, e.g. probabilistic or dynamic models, gene-regulatory networks, protein interaction networks or metabolic networks
G06F 19/24 - for machine learning, data mining or biostatistics, e.g. pattern finding, knowledge discovery, rule extraction, correlation, clustering or classification
The invention provides an element (210) comprising: (i) an electrical component (1220); (ii) an optical medium (270) comprising medium material (275) comprising a silicone transmissive for one or more of UV radiation and visible radiation, wherein the electrical component (1220) is embedded in the optical medium (270); (iii) an electrical connector (510) for functionally coupling the electrical component (1220) external to the optical medium (270), wherein the electrical connector (510) is embedded in the optical medium (270) over at least part of its length; and (iv) a water barrier (530) at least partly embedded in the optical medium (270) and configured to enclose at least part of the electrical connector (510).
An apparatus for determining a depth map for an image of a scene comprises an active depth sensor (103) and a passive depth sensor (105) for determining a depth map for the image. The apparatus further comprises a light determiner (109) which determines a light indication indicative of a light characteristic for the scene. The light indication may specifically reflect a level of visible and/or infrared light for the scene. A depth map processor (107) determines an output depth map for the image by combining the first depth map and the second depth map. Specifically, a depth value for the output depth map is determined as a combination of depth values of the first and the second depth map where the combining is dependent on the light indication. The light determiner (109) estimates the first infrared light indication from a visible light indication indicative of a light level in a frequency band of the visible light spectrum.
A pressure cooking device (10, 100) for cooking food materials (80), comprising: a sealed cooking chamber (20) arranged to accommodate food materials (80); a steam supplying unit (30, 130) arranged to supply steam to the sealed cooking chamber (20); and a steam channel (40) arranged to interconnect the steam supplying unit (30, 130) and the sealed cooking chamber (20); wherein the pressure cooking device (10, 100) further comprises a control unit (11) adapted to control the cooking process based on the liquid water content and/or the humidity in the sealed cooking chamber (20). By virtue of this invention, the liquid water content and/or the humidity in the sealed cooking chamber (20) could be adjusted conveniently.
The invention provides a vessel (1) comprising a hull (21) with a coating layer (100), the vessel (1) further comprising an anti-biofouling system (200) comprising an optical medium and a light source configured to provide UV radiation, wherein the optical medium (270) is transmissive for light, wherein the optical medium comprises a radiation escape surface and a second optical medium surface with at least part of the transmissive optical medium material configured between said radiation escape surface and said second optical medium surface, wherein the optical medium is configured adjacent to at least part of the coating layer with the second optical medium surface configured closer to the hull (21) than the radiation escape surface, wherein the anti-biofouling system (200) is configured to provide said UV-radiation downstream from said radiation escape surface in a direction away from said hull (21), and wherein the vessel (1) further comprises a pattern comprising colored segments and UV reflective segments with at least part of the transmissive optical medium material configured between said pattern and said radiation escape surface.
An apparatus receives an image and an associated depth map comprising input depth values. A contour detector (405) detects contours in the image. A model processor (407) generates a contour depth model for a contour by fitting a depth model to input depth values for the contour. A depth value determiner (409) determines a depth model depth value for at least a one pixel of the contour from the contour depth model. The depth model may e.g. correspond to a single depth value which e.g. may be set to a maximum input depth value. A modifier (411) generates a modified depth map from the associated depth map by modifying depth values of the associated depth map. This includes generating a modified depth value for a pixel in the modified depth map in response to the depth model depth value. The depth model depth value may e.g. replace the input depth value for the pixel.
An assembly comprises a wet compartment (100) having at least one inlet opening for allowing water to enter the wet compartment (100), a functional unit (2) located in the wet compartment (100), a dry area (200) which cannot be reached by water and which is outside of the wet compartment (100), a barrier (110) situated between the dry area (200) and the wet compartment (100), and at least one energy source (20) which is arranged and configured to emit energy for preventing biofouling of at least an exterior surface (17) of the functional unit (2), wherein the energy source (20) is arranged in the dry area (200), a path (112) being present between the dry area (200) and the wet compartment (100) for allowing energy emitted by the energy source (20) during operation thereof to reach the wet compartment (100), through the barrier (110).
F28D 1/02 - Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or mo with the heat-exchange conduits immersed in the body of fluid
62.
METHOD AND DEVICE FOR BIOFOULING PREVENTION ON VESSELS BY MEANS OF UV RADIATION AND SURFACE MODIFICATION
The invention provides an object (10), that during use is at least partly submerged in water, wherein the object (100) is selected from the group consisting of a vessel (1) and an infrastructural object (15), the object (10) further comprising an anti- biofouling system (200) comprising an UV emitting element (210), wherein the UV emitting element (210) is configured to irradiate with UV radiation (221) during an irradiation stage one or more of (i) a first part (111) of an external surface (11) of said object (10) and (ii) water adjacent to said first part (111) of said external surface (11) of saidobject (10), wherein the object (10) further comprises protruding elements (100) with the UV emitting element (210) configured between the protruding elements (100) and configured depressed relative to the protruding elements (100).
The invention provides an object (10) that during use is at least partly submerged in water, the object (10) further comprising an anti-bio fouling system (200) comprising an UV emitting element (210), wherein the UV emitting element (210) comprises one or more light sources (220) and is configured to irradiate with UV radiation (221) during an irradiation stage one or more of (i) a part (111) of an external surface (11) of said object (10) and (ii) water adjacent to said part (111) of said external surface (11), wherein the object (10) is selected from the group consisting of a vessel (1) and an infrastructural object (15), wherein the object (10) further comprises a water switch (400), wherein the anti-bio fouling system (200) is configured to provide said UV radiation (221) to said part (111) in dependence of the water switch (400) being in physical contact with the water.
The invention provides an object (10) that during use is at least partly submerged in water, the object (10) further comprising an anti-biofouling system (200) comprising an UV emitting element (210), wherein the UV emitting element (210) is configured to irradiate with UV radiation (221) during an irradiation stage one or more of (i) a part (111) of an external surface (11) of said object (10) and (ii) water adjacent to said part (111) of said external surface (11), wherein the light source (220) is at least controllable between a first UV radiation level and a second UV radiation level, wherein the first UV radiation level is larger than the second UV radiation level, wherein the object (10) is selected from the group consisting of a vessel (1) and an infrastructural object (15), wherein the object (10) further comprises a control system (300) configured to control said UV radiation (221) as function of input information comprising information of one or more of (i) a location of the object (10), (ii) movement of the object (10), (iii) a distance (d) of the object (10) to a second object (20), and (iv) a position of the part (111) of the external surface (11) relative to the water.
An apparatus for determining a depth map for an image comprises an image unit (105) which provides an image with an associated depth map comprising depth values for at least some pixels of the image. A probability unit (107) determines a probability map for the image comprising probability values indicative of a probability that pixels belong to a text image object. A depth unit (109) generates a modified depth map where the modified depth values are determined as weighted combinations of the input values and a text image object depth value corresponding to a preferred depth for text. The weighting is dependent on the probability value for the pixels. The approach provides a softer depth modification for text objects resulting in reduced artefacts and degradations e.g. when performing view shifting using depth maps.
A display image for a display panel (503) of an autostereoscopic display projecting the display image in a plurality of view cones is generated. A source (803) provides a three dimensional representation of a scene to be displayed and a generator (805) generates the display image from the representation. For each pixel, the generator (805) determines a scene viewpoint direction indication reflecting a view point direction for the scene in response to a direction mapping function and a view cone projection direction indication reflecting a projection direction for the pixel within the view cones. The direction mapping function reflects a relationship between view cone projection directions and scene view point directions. The pixel value corresponding to the view point direction is then generated from the three dimensional representation. In addition, a processor (809) determines a viewer characteristic; and an adapter (811) for adapts the direction mapping function in response to the viewer characteristic.
H04N 13/368 - Image reproducers using viewer tracking for two or more viewers
H04N 13/305 - Image reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using lenticular lenses, e.g. arrangements of cylindrical lenses
67.
METHOD AND APPARATUS FOR ESTIMATING THE QUANTITY OF MICROORGANISMS WITHIN A TAXONOMIC UNIT IN A SAMPLE
Methods and apparatus to identify and quantify the microorganisms present in a sample. Sequence reads are classified using existing methods, but the classification results are corrected to account for the number of reads expected to be falsely classified as determined through simulation. With statistics on the expected number of reads misclassified, a linear least squares method (non-negative or otherwise) or other related technique can be used to adjust the number of reads that are classified to various taxonomic units (e.g., species) and to determine more accurate values for the quantities of those taxonomic units actually present in the sample, eliminating microorganisms in taxonomic units falsely determined to be present in the sample.
G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
G06F 19/10 - Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology (in silico methods of screening virtual chemical libraries C40B 30/02;in silico or mathematical methods of creating virtual chemical libraries C40B 50/02)
G06F 19/24 - for machine learning, data mining or biostatistics, e.g. pattern finding, knowledge discovery, rule extraction, correlation, clustering or classification
68.
DISPLAY DEVICE WITH DIRECTIONAL CONTROL OF THE OUTPUT, AND A BACKLIGHT FOR SUCH A DISPLAY DEVICE AND A LIGHT DIRECTION METHOD
A display backlight comprises an edge-lit lightguide having an array of light out-coupling structures to enable light to escape from the lightguide at the location of the light out-coupling structures. A light source arrangement is used for providing light into the lightguide at one or both of the opposite side edges. The light source arrangement is controllable to provide a selected one of at least first and second light outputs into the lightguide, the two light outputs having a different angle to the general plane of the lightguide and resulting in light which escapes from the lightguide with a different range of exit angles. In this way, a directional backlight output is enabled, based on the way light is coupled into a lightguide. This provides a simple structure only requiring control of the light provided to the lightguide. The backlight may for example enable an autostereoscopic display to be formed without the need for a lenticular array.
Methods and systems for monitoring and determining antimicrobial resistance and antimicrobial treatment using genomic subtype information. Various embodiments utilize molecular epidemiology and next-generation sequencing technologies (NGS) to monitor multi-drug resistant pathogens and provide early insight into emergent microbial threats.
G06F 19/26 - for data visualisation, e.g. graphics generation, display of maps or networks or other visual representations
G06F 19/10 - Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology (in silico methods of screening virtual chemical libraries C40B 30/02;in silico or mathematical methods of creating virtual chemical libraries C40B 50/02)
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
70.
METHODS OF DISPLAYING THE ANTIMICROBIAL SENSITIVITY OF BIOLOGICAL ISOLATES
Methods and systems for monitoring and determining antimicrobial resistance and antimicrobial treatment using genomic subtype information. Various embodiments utilize molecular epidemiology and next-generation sequencing technologies (NGS) to monitor multi-drug resistant pathogens and provide early insight into emergent microbial threats.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
G06F 19/26 - for data visualisation, e.g. graphics generation, display of maps or networks or other visual representations
C12Q 1/18 - Testing for antimicrobial activity of a material
An autostereoscopic display comprises a pixelated display panel comprising an array of single color pixels or an array of sub-pixels of different colors and a view forming arrangement comprising an array of lens elements. The pixels form a square (or near square) grid, and the lenses also repeat in a square (or near square) grid. A vector p is defined which relates to a mapping between the pixel grid and the lens grid. Regions in the two dimension space for this vector p are identified which give good or poor banding performance, and the better banding performance regions are selected.
G02B 30/27 - Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images by providing first and second parallax images to an observer’s left and right eyes of the autostereoscopic type involving lenticular arrays
An autostereoscopic display comprises a pixelated display panel comprising an array of single color pixels or an array of sub-pixels of different colors and a view forming arrangement comprising an array of lens elements. The pixels form a hexagonal grid, and the lenses also repeat in a hexagonal grid. A vector p is defined which relates to a mapping between the pixel grid and the lens grid. Regions in the two dimensional space for this vector p are identified which give good or poor banding performance, and the better banding performance regions are selected.
G02B 30/27 - Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images by providing first and second parallax images to an observer’s left and right eyes of the autostereoscopic type involving lenticular arrays
73.
VIRTUAL INTERACTIVE DEFINITION OF VOLUMETRIC SHAPES
A CPR assistance system comprises a sensor for making a physiological measurement to generate a sensor signal which conveys information concerning the point in time at which venous return is completed. Time points are then determined at which CPR compression cycles should be administered, and output information is provided relating to the determined time points. The output information may be visual or audible advice to a person giving CPR or it may be control information for controlling an automated CPR system.
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
75.
A PERSONAL SAFETY AND SECURITY MOBILE APPLICATION RESPONSIVE TO CHANGES IN HEART RATE
A software app for a mobile device is disclosed for alerting a custodian of a person to be protected of an emergency situation involving the person to be protected. The app includes software instructions for carrying out a method including: establishing a range of normal heart rates for the person using a heart rate monitor; detecting a heart rate for the person that is outside of the established range; activating at least one of a camera, a microphone, an accelerometer, and a location indicator on the mobile device carried by the person; establishing a wireless data connection between the mobile device and a communication network; and transmitting data to the custodian from the activated camera, microphone, accelerometer, or location indicator via the communication network. The app can notify a custodian of a medical or safety emergency as it is happening, giving that custodian the ability to immediately notify emergency personnel.
The present application mainly relates to specific method for determining a risk score that indicates a risk that a subject will experience a clinical event within a definedn period of time. The risk score is determined based on a combination of inferred activities of two or more cellular signaling pathways in a subject, wherein the cellular signaling pathways comprise a PI3K pathway and one or more of a Wnt pathway, an ER pathway, and an HH pathway. The present application also relates to an apparatus, to a non-transitory storage medium, and to a computer program for determining a risk score that indicates a risk that a subject will experience a clinical event within a definedn period of time. The present invention also relates to a kit for measuring expression levels of three or more target genes of each of two or more cellular signaling pathways in a sample of a subject, to kits for determining a risk score that indicates a risk that a subject will experience a clinical event associated with a disease within a defined period of time, and to uses of the kits in performing the method.
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
77.
MEDICAL PROGNOSIS AND PREDICTION OF TREATMENT RESPONSE USING MULTIPLE CELLULAR SIGNALING PATHWAY ACTIVITIES
Van Strijp, Dianne Arnoldina Margaretha Wilhelmina
Van Gog, Robert
Abstract
The present application mainly relates to specific method for determining a risk score that indicates a risk that a subject will experience a clinical event within a defined period of time. The risk score is determined based on a combination of inferred activities of two or more cellular signaling pathways in a subject, wherein the cellular signaling pathways comprise a TGF-ß pathway and one or more of a PI3K pathway, a Wnt pathway, an ER pathway, and an HH pathway. The present application also relates to an apparatus, to a non-transitory storage medium, and to a computer program for determining a risk score that indicates a risk that a subject will experience a clinical event within a defined period of time. The present invention also relates to a kit for measuring expression levels of three or more target genes of each of two or more cellular signaling pathways in a sample of a subject, to kits for determining a risk score that indicates a risk that a subject will experience a clinical event associated with a disease within a defined period of time, and to uses of the kits in performing the method.
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
78.
ASSESSMENT OF TGF-.BETA. CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
Van Strijp, Dianne Arnoldina Margaretha Wilhelmina
Abstract
The present invention relates to a computer-implemented method for inferring activity of a TGF-ß cellular signaling pathway in a subject based on expression levels of three or more target genes of the TGF-ß cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a TGF-ß cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the TGF-ß cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a TGF-ß cellular signaling pathway in a subject, and to the use of such kits in performing the method.
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
79.
PROCESSING OF DISPARITY OF A THREE DIMENSIONAL IMAGE
An apparatus for reducing the visibility of disparity estimation errors at edges, and in particular at overlays. The apparatus comprises a receiver (401) for receiving a three dimensional image represented by at least image values (brightness/ contrast values) and a disparity value. A subset selector (403) evaluates an image property criterion for the image value for a group of pixels and determines a subset of pixels of the group of pixels for which the image property criterion is met. The criterion may for example reflect whether the pixel belongs to an image object edge. A distribution evaluator (405) generates a frequency distribution for disparity values of the subset of pixels and an analyzer (407) determines a shape property for the frequency distribution (the presence of a peak). An adaptor (409) determining a disparity remapping in response to the shape property and a remapper (411) modifies disparity values of the three dimensional image by applying the disparity remapping. The approach may e.g. reduce image depth when overlay graphics is likely to be present.
The present invention relates to a device and method for determining vital sign information of a subject (2). The proposed device comprises an input unit (11) for receiving image data of the subject, said image data including a sequence of images over time, an ROI selection unit (12) for selecting an initial region of interest, ROI, within an image, a feature selection unit (13) for selecting one or more spatial features of a body part within the initial ROI, a motion signal extraction unit (14) for extracting from said image data within the initial ROI the direction and/or amplitude of motion of a subject's body part related to a desired vital sign of the subject, a detection unit (15) for detecting one or more spatial features of said selected spatial features, whose motion is not related to the desired vital sign of the subject, a tracking unit (16) for tracking the initial ROI based on changes of the position of said one or more detected spatial features within the initial ROI, to obtain a final ROI, and a vital signs extraction unit (17) for extracting the desired vital sign from the final ROI.
An autostereoscopic display uses a beam control system and a pixellated spatial light modulator. Different display modes are provided for the displayed image as a whole or for image portions. These different modes provide different relationships between angular view resolution, spatial resolution and temporal resolution. The different modes make use of different amounts of beam spread produced by the beam control system.
H04N 13/305 - Image reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using lenticular lenses, e.g. arrangements of cylindrical lenses
H04N 13/315 - Image reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using parallax barriers the parallax barriers being time-variant
G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the position or the direction of light beams, i.e. deflection
82.
VISUALIZING VOLUMETRIC IMAGE OF ANATOMICAL STRUCTURE
A system and method is provided for visualizing a volumetric image of an anatomical structure. Using a first view of the volumetric image showing a non-orthogonal cross-section of a surface of the anatomical structure, a local orientation of the surface within the volumetric image is determined, namely by analyzing the image data of the volumetric image. Having determined the local orientation of the surface, a second view is generated of the volumetric image, the second view being geometrically defined by a viewing plane intersecting the surface of the anatomical structure in the volumetric image orthogonally. Accordingly, the surface is shown in a sharper manner in the second view than would typically be the case in the first view. Advantageously, the user can manually define or correct a delineation of the outline of the anatomical structure in a more precise manner. Moreover, various other advantageously uses of such a second view exist, such as facilitating the image interpretation by the clinician, more reliable further automatic analysis, etc.
A system and a method are provided for analyzing an image of an aortic valve structure to enable assessment of aortic valve calcifications. The system comprises an image interface for obtaining an image of an aortic valve structure, the aortic valve structure comprising aortic valve leaflets and an aortic bulbus. The system further comprises a segmentation subsystem for segmenting the aortic valve structure in the image to obtain a segmentation of the aortic valve structure. The system further comprises an identification subsystem for identifying a calcification on the aortic valve leaflets by analyzing the image of the aortic valve structure. The system further comprises an analysis subsystem configured for determining a centerline of the aortic bulbus by analyzing the segmentation of the aortic valve structure, and for projecting the calcification from the centerline of the aortic bulbus onto the aortic bulbus, thereby obtaining a projection indicating a location of the calcification as projected onto the aortic bulbus. The system further comprises an output unit for generating data representing the projection. Provided information on the accurate location of calcifications after a valve replacement may be advantageously used, for example, to effectively analyze the risk of paravalvular leakages of Transcatheter aortic valve implantation (TAVI) interventions for assessing the suitability of a patient for TAVI procedure.
Anti-fouling lighting system (1) for preventing or reducing bio fouling on a fouling surface (1201) of an object (1200), by providing an anti-fouling light (211) via an optical medium (220) to said fouling surface, the anti-fouling lighting (1) system comprising: (a) a lighting module (200) comprising (i) a light source (210) configured to generate an anti-fouling light (211), and (ii) said optical medium (220) configured to receive at least part of the anti-fouling light (211), the optical medium (220) comprising an emission surface (222) configured to provide at least part of said anti-fouling light (211); and (b) a control system (300) configured to control an intensity of the anti-fouling light (211) as function of one or more of (i) a feedback signal related to a biofouling risk and (ii) a timer for time-based varying the intensity of the anti-fouling light (211).
An autostereoscopic 3D display comprises a first unit (503) for generating an intermediate 3D image. The intermediate 3D image comprises a plurality of regions and the first unit (503) is arranged to generate a first number of image blocks of pixel values corresponding to different view directions for the region regions. The number of image blocks is different for some regions of the plurality of regions. A second unit (505) generates an output 3D image comprising a number of view images from the intermediate 3D image, where each of the view images correspond to a view direction. The display further comprises a display arrangement (301) and a driver (507) for driving the display arrangement (301) to display the output 3D image. An adaptor (509) is arranged to adapt the number of image blocks for a first region in response to a property of the intermediate 3D image or a representation of a three dimensional scene from which the first image generating unit (503) is arranged to generate the intermediate image.
In a Personal Emergency Response System (PERS) service, activation of a wearable call device (10) by a PERS client causes a speakerphone console (12) to connect with a PERS call center (18) to enable the PERS client to converse with a call center operator while a PERS client profile is retrieved from a PERS database (52) and displayed on a display component (44) at the PERS call center. From the profile, values of a set of features are generated for the PERS client. An emergency dispatch risk prediction or other risk prediction is computed over a future time horizon for the PERS client based on the generated values of the set of features, and is displayed on the display component. The risk prediction may be wirelessly sent to a mobile device (80) for display on the mobile device.
H04W 4/30 - Services specially adapted for particular environments, situations or purposes
G08B 21/02 - Alarms for ensuring the safety of persons
H04M 11/04 - Telephonic communication systems specially adapted for combination with other electrical systems with alarm systems, e.g. fire, police or burglar alarm systems
87.
METHOD AND APPARATUS FOR EXERCISE MONITORING COMBINING EXERCISE MONITORING AND VISUAL DATA WITH WIRELESS WEARABLE DEVICES
Embodiments of the invention provide a method and apparatus for a wireless exercise monitoring system for interactively monitoring an aspect of exercise, sports, or fitness utilizing a wearable device, such as a watch, eyewear, or smart apparel. The device is equipped with, or connected to, a digital camera. Sensors integrated with, or wirelessly connected to, the wearable internet device record physiological data during exercise and data measuring the amount of exercise performed. The data and visual images from the camera are transmitted to one or more internet servers, and may be shared with other mobile internet devices.
The present invention relates to a device (16) for remotely obtaining vital sign information of a living being (14) under phototherapy treatment. The device comprises a detection unit (22) for detecting light of at least one wavelength interval reflected from at least a region of interest (20) of the living being (14) and for generating an input signal from the detected light; a processing unit (24) for processing the input signal and deriving vital sign information of said living being (14) from said input signal by use of remote photoplethysmography and/or motion analysis; and a control unit (26) for controlling at least one of the detection unit (22) and an illumination unit (12) for providing the phototherapy treatment to the living being (14) based on the configuration of the detection unit (22) and based on the configuration of the illumination unit (12). The present invention further relates to a corresponding method as well as to a phototherapy apparatus (10) including a device as described above.
The present invention relates to a method comprising inferring activity of a PI3K cellular signaling pathway in a tissue and/or cells and/or a body fluid of a medical subject based at least on expression levels of one or more target gene(s) of the PI3K cellular signaling pathway measured in an extracted sample of the tissue and/or the cells and/or the body fluid of the medical subject. The present invention further relates to an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method.
A heart rate monitor (40) for detecting a pulse of a person (10) employs a platform (43), a plurality of multi-axis accelerometers (41R, 41L) and a pulse detector (44). The multi-axis accelerometers (41R, 41L) are adjoined to the platform (43) to generate differential mode signals (AZR, AZL) indicative of a sensing by the accelerometers (41) of physiological motion (12) of the person (10) relative to acceleration sensing axes (42R, 42L) and to generate common mode signals (AXR, AXL, AYR, AYL) indicative of a sensing by the accelerometers (41R, 41L) of extraneous motion by the person (10) relative to the acceleration sensing axes (42R, 42L). The pulse detector (44) is operably connected to the multi-axis accelerometers (41R, 41L) to generate a pulse signal (PS)as a function of a vertical alignment of the acceleration sensing axes (42R, 42L) combining the differential mode signals (AZR, AZL) and cancelling the common mode signals (AXR, AXL, AYR, AYL).
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
91.
PROCESSOR FOR PROCESSING SKIN CONDUCTANCE DATA AND DEVICE FOR DETECTING AT LEAST ONE STAGE OF BURNOUT AND/OR CHRONIC FATIGUE SYNDROME OF A LIVING BEING
The present invention relates to a processor for processing skin conductance data of a living being, comprising an input unit (12) for receiving a skin conductance data signal (13) comprising a plurality of data peaks, a calculating unit (14) for computing a skin conductance peak data signal over a long-term period by deriving a feature related to said data peaks from said skin conductance data signal (13) and forming a summation of said feature per time unit and an analyzing unit (16) for analyzing an average and/or an absolute value of said skin conductance peak data signal over at least a portion of said period to get information on at least one stage of burnout and/or chronic fatigue syndrome of said living being.
A system and method for automatically setting image viewing context. The system and method perform the steps of extracting image references and body parts associated with the image references from a report, mapping each of the body parts to an image viewing context so that image references associated are also associated with the image viewing context, receiving a user selection indicating an image to be viewed, determining whether the user selection is one of the image references associated with the image viewing context and displaying the image of the user selection
G16H 30/00 - ICT specially adapted for the handling or processing of medical images
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
93.
DEVICE AND METHOD FOR OBTAINING PULSE TRANSIT TIME AND/OR PULSE WAVE VELOCITY INFORMATION OF A SUBJECT
The present invention relates to a device and method for obtaining pulse transit time and/or pulse wave velocity information of a subject (14). Based on a set of image frames (19) of a subject (14) and detected motion of body parts of the subject (14) regions of interest are selected from different non-moving body parts and pulse transit time and/or pulse wave velocity information is obtained from acquired PPG signals extracted from different regions of interest and the respective determined physical distance between the respective regions of interest.
Systems and methods for electrocardiography monitoring use multiple capacitive sensors in order to determine reliable measurements of electrophysiological information of a patient. Relative coupling strength and/or reliability is used to select dynamically which sensors to use in order to determine, in particular, an electrocardiogram of the patient.
A monitoring system (10) includes at least one video camera (14), a motion unit (40), and a segmentation unit (42). The at least one video camera (14) is configured to continuously receive video of a subject in normal and darkened room conditions. The motion unit (40) identifies clusters of motion of the subject based on respiratory and body part motion inthe received video of the subject. The segmentation unit (42) segments body parts of the subject based on the identified clusters of subject motion.
The present invention relates toa processor and a system (1, 1') for screening of the state of oxygenation of a subject (100), in particular for screening of newborn babies for congenital heart disease. The system comprises an imaging unit (2) for obtaining a plurality of image frames of the subject (100) over time, and a processor (3) for processing the image frames. The imaging unit, for instance a conventional video camera as used in the vital signs monitoring using the above mentioned principle of remote PPG, is used as a contact less pulse oximeter, by use of which a body map (for at least some body parts of interest) of at least the blood oxygen saturation is created. Picking certain body areas, e.g. right upper extremity versus left upper and/or lower extremity,and combining or comparing them can serve the purpose of detecting anomalies of heart and/or circuitry functions.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
97.
OPTIMIZED SCALE FACTOR FOR FREQUENCY BAND EXTENSION IN AN AUDIOFREQUENCY SIGNAL DECODER
L'invention se rapporte à un procédé de détermination d'un facteur d'échelle optimisé à appliquer à un signal d'excitation ou à un filtre lors d'un procédé d'extension de bande de fréquence d'un signal audiofréquence, le procédé d'extension de bande (E601) comportant une étape de décodage ou d'extraction, dans une première bande de fréquence, d'un signal d'excitation et de paramètres de la première bande de fréquence comprenant des coefficients d'un filtre de prédiction linéaire, une étape de génération d'un signal d'excitation étendu sur au moins une deuxième bande de fréquence et une étape de filtrage par un filtre de prédiction linéaire pour la deuxième bande de fréquence. Le procédé de détermination comporte les étapes de détermination (E602) d'un filtre de prédiction linéaire dit filtre additionnel, d'ordre inférieur au filtre de prédiction linéaire de la première bande de fréquence, les coefficients du filtre additionnel étant obtenus à partir des paramètres décodés ou extraits de la première bande de fréquence et de calcul (E603) du facteur d'échelle optimisé en fonction au moins des coefficients du filtre additionnel. L'invention se rapporte également à un dispositif de détermination d'un facteur d'échelle optimisé mettant en uvre le procédé tel que décrit et à un décodeur comprenant un tel dispositif.
Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.
A patient monitor device includes one or more sensors which measure physiological parameters of a patient, a controller which controls an audio source to generate an audible tone and adjust the pitch of the audible tone to indicate the measured physiological parameter according to a mapping scheme, the audio source which generates the audio tone, and an audio output device which outputs the audible tone. The mapping scheme clamping a frequency of the audible tone after reaching a predetermined threshold.
A medical device (10), medical method and graphical user interface (GUI) (18) displaying data regarding measurement of a physiological parameter. A window (22) for the physiological parameter is displayed using a display device (20). The window (22) includes an indicator (24) identifying a measured value of the physiological parameter. In response to automatic trigger of measurement of the physiological parameter, the window (22) is updated to further include a first indicator (34) indicating measurement of the physiological parameter is ongoing. In response to manual trigger of measurement of the physiological parameter, the window (22) is updated to replace the indicator (24) identifying the measured value with a second indicator (36) indicating measurement of the physiological parameter is ongoing. The second indicator (36) is prominent relative to the first indicator (34).
patents
