Global Life Sciences Solutions Operations UK Limited

United Kingdom

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C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 39
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 29
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA 27
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides 19
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay 14
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1.

VIRAL FILTER AND METHOD OF VIRAL FILTRATION

      
Application Number 18551012
Status Pending
Filing Date 2022-03-17
First Publication Date 2024-06-06
Owner Global Life Sciences Solutions Operations UK Ltd. (United Kingdom)
Inventor
  • Nunes, Claudia Trindade
  • Lorenzetti, Martina

Abstract

The present invention provides for simple and rapid filtering of biological samples, whereby a sample can be analyzed in the same device or a different device. In one preferred example, a membrane filter 12 that is particularly useful for the filtration of samples comprising viruses along with other biological materials that need be separated from the viruses is used. A lateral flow device 10 incorporating a filter membrane/membrane filter 12 is also disclosed.

IPC Classes  ?

  • B01D 63/08 - Flat membrane modules
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 69/12 - Composite membranes; Ultra-thin membranes
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

2.

POROUS POLYMERIC MEMBRANE WITH TEAR PREVENTION RING

      
Application Number 18396391
Status Pending
Filing Date 2023-12-26
First Publication Date 2024-04-18
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
Inventor
  • Albagli, Douglas
  • Hennessy, William A.

Abstract

Porous liquid-filtering membranes are provided having a boundary region substantially surrounding the pore region and having greater tear resistance than the pore region.

IPC Classes  ?

  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors

3.

Tissue processing bag

      
Application Number 29778672
Grant Number D0988538
Status In Force
Filing Date 2021-04-14
First Publication Date 2023-06-06
Grant Date 2023-06-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Divekar, Devina
  • Rajan, Thiyaga

4.

Tissue processing bag clamp

      
Application Number 29778720
Grant Number D0987851
Status In Force
Filing Date 2021-04-14
First Publication Date 2023-05-30
Grant Date 2023-05-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Divekar, Devina
  • Marteleur, Klas
  • Lundberg, Joergen
  • Hari, Priya

5.

CELL-FREE PROTEIN EXPRESSION USING ROLLING CIRCLE AMPLIFICATION PRODUCT

      
Application Number 17813568
Status Pending
Filing Date 2022-07-19
First Publication Date 2022-12-08
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.

IPC Classes  ?

  • C12P 21/00 - Preparation of peptides or proteins
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression

6.

IMPROVEMENTS IN AND RELATING TO THE MONITORING OF CELL EXPANSION

      
Application Number 17617274
Status Pending
Filing Date 2020-06-09
First Publication Date 2022-09-22
Owner
  • Global Life Sciences Solutions Operations UK LTD (United Kingdom)
  • The Regents of the University of California (USA)
Inventor
  • Goodwin, Paul C.
  • Bowles, Paul Anthony
  • Iyer, Rohin
  • Gratch, Yarden
  • Mccartney, Mitch M.
  • Yamaguchi, Mei S.
  • Davis, Cristina E.

Abstract

Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.

IPC Classes  ?

  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12N 5/075 - Oocytes; Oogonia
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
  • G01N 30/02 - Column chromatography
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 33/483 - Physical analysis of biological material

7.

Porous polymeric membrane with tear prevention ring

      
Application Number 17115054
Grant Number 11896934
Status In Force
Filing Date 2020-12-08
First Publication Date 2022-06-09
Grant Date 2024-02-13
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
Inventor
  • Albagli, Douglas
  • Hennessy, William A.

Abstract

Porous liquid-filtering membranes are provided having a boundary region substantially surrounding the pore region and having greater tear resistance than the pore region.

IPC Classes  ?

  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors

8.

Biological Sample Collectors and Handling Thereof

      
Application Number 17160450
Status Pending
Filing Date 2021-01-28
First Publication Date 2021-09-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth
  • Norey, Christopher George
  • Pierce, Alan Stuart
  • John, Robert

Abstract

A biological sample collector 500 comprising a solid support 12 having plural discrete areas (22,24,26,28 FIG. 1) for accepting a biological sample, each area being chemically differentiated, for example by having a different chemical treatment sorbed onto the solid support. An envelope 530 encloses the solid support. A cover portion 520 can cover the biological sample after collection to prevent infection. UV light can be applied to the collected sample to reduce the risk of infection.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat

9.

Solid Support for Sample Collection

      
Application Number 17237518
Status Pending
Filing Date 2021-04-22
First Publication Date 2021-08-05
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Moran, Nina

Abstract

The present invention relates to means for collection of biological samples. Specifically, the present invention provides a solid support for collection, storage and subsequent analysis of a biological sample as well as methods for use of the solid support of the invention and a kit comprising the solid support of the invention.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • G01N 1/02 - Devices for withdrawing samples
  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state

10.

Device and Method for Sample Isolation

      
Application Number 16607233
Status Pending
Filing Date 2018-04-11
First Publication Date 2020-12-03
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James
  • Pierce, Alan
  • Schenk, Alexander
  • Fullerton, Rebecca Ngaire

Abstract

The present invention relates to a device and method for sample preparation and collection. More closely the invention relates to a device to isolate DNA, RNA and proteins or other biomolecules in one single step from the same undivided sample

IPC Classes  ?

  • G01N 33/538 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip
  • C07K 1/34 - Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
  • C07K 1/36 - Extraction; Separation; Purification by a combination of two or more processes of different types
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01D 69/12 - Composite membranes; Ultra-thin membranes
  • B01D 69/14 - Dynamic membranes

11.

Methods and reagents for reverse-transcription polymerase chain reaction

      
Application Number 15534711
Grant Number 10822645
Status In Force
Filing Date 2017-06-09
First Publication Date 2020-11-03
Grant Date 2020-11-03
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Yarunin, Alexander
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Fullerton, Rebecca

Abstract

The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a polyol, a serum albumin, a non-ionic surfactant and a reducing agent.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
  • C12Q 1/686 - Polymerase chain reaction [PCR]

12.

Micro-needle sampling device and use thereof

      
Application Number 15760062
Grant Number 11229422
Status In Force
Filing Date 2016-10-03
First Publication Date 2020-07-23
Grant Date 2022-01-25
Owner Global Life Sciences Solutions Operations UK Ltd. (United Kingdom)
Inventor
  • Lamerton, Kathryn Louise
  • Smith, Michael John

Abstract

The present invention relates to a device (10) for obtaining a sample (30) from a biological material (40) in solid form, said device comprising an array of micro-needles (30) arranged on a base plate (20). It further relates to a method for obtaining a sample (50) from a biological material (40) in solid form, comprising pressing the micro-needles (30) of the device (10) into said biological material (40), and subsequently removing the device from the biological material (40), and to the use of the device (10) in such a method.

IPC Classes  ?

  • A61B 10/02 - Instruments for taking cell samples or for biopsy
  • G01N 1/08 - Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

13.

Electrospun fibers for protein stabilization and storage

      
Application Number 16261532
Grant Number 11555215
Status In Force
Filing Date 2019-01-29
First Publication Date 2019-05-23
Grant Date 2023-01-17
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Li, Bing
  • Moore, David Roger
  • Alberts, William Christopher
  • Nelson, John Richard

Abstract

An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

14.

In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides

      
Application Number 15707074
Grant Number 10350307
Status In Force
Filing Date 2017-09-18
First Publication Date 2019-03-21
Grant Date 2019-07-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Davis, Brian Michael
  • Nelson, John Richard
  • Gao, Wei

Abstract

A method for in vivo RNA or protein expression is provided. The method includes introducing a double-stranded concatemeric DNA into a eukaryotic cell to generate a desired RNA or protein. The double-stranded concatemeric DNA includes a plurality of tandem repeat sequences, wherein each of the plurality of tandem repeat sequences comprises an expression sequence. The double-stranded concatemeric DNA comprises one or more phosphorothioated nucleotides, wherein a ratio of phosphorothioated nucleotides to total nucleotides in the double-stranded concatemeric DNA is at least 1:1600. A eukaryotic cell comprising an exogeneous, double-stranded concatemeric DNA comprising the plurality of tandem repeat sequences is also provided.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

15.

Methods and reagents for reverse-transcription polymerase chain reaction

      
Application Number 15534578
Grant Number 10858694
Status In Force
Filing Date 2015-12-18
First Publication Date 2019-03-14
Grant Date 2020-12-08
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Yarunin, Alexander
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Fullerton, Rebecca

Abstract

The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a) a polar aprotic solvent; b) a serum albumin; and optionally c) a non-ionic surfactant and/or a betaine.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

16.

Cell-free protein expression using rolling circle amplification product

      
Application Number 16041734
Grant Number 11421259
Status In Force
Filing Date 2018-07-20
First Publication Date 2019-03-07
Grant Date 2022-08-23
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12P 21/00 - Preparation of peptides or proteins
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression

17.

Endonuclase-assisted isothermal amplification using contamination-free reagents

      
Application Number 15941057
Grant Number 11268116
Status In Force
Filing Date 2018-03-30
First Publication Date 2019-02-28
Grant Date 2022-03-08
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Duthie, Robert Scott
  • Nelson, John Richard
  • Sekher, Anuradha

Abstract

Disclosed are methods and kits for endonuclease-assisted DNA amplification reaction using decontaminated primer solutions that are pre-treated with a nuclease. Nucleic acid amplification assays that employ nuclease-resistant, inosine-containing primers, endonuclease V enzymes to introduce a nick into a target DNA comprising at least one inosine, and a DNA polymerase to generate amplicons of a target DNA are also disclosed.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

18.

Cell-free protein expression using double-stranded concatameric DNA

      
Application Number 15631510
Grant Number 11001868
Status In Force
Filing Date 2017-08-11
First Publication Date 2019-02-14
Grant Date 2021-05-11
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Nelson, John Richard
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation using a double-stranded concatemeric DNA in a eukaryotic cell-free expression system are provided. The method includes the steps of (a) contacting a double-stranded concatemeric DNA with a eukaryotic cell-free expression system, and (b) expressing a protein in vitro from the double-stranded concatemeric DNA in the eukaryotic cell-free expression system. The double-stranded concatemeric DNA includes a plurality of tandem repeat sequences. The plurality of tandem repeat sequences includes an expression sequence including a promoter, a cap-independent translation element (CITE), and an open reading frame. A final concentration of the double-stranded concatemeric DNA in the eukaryotic cell-free expression system is in a range from about 0.1 ng/μL to about 35 ng/μL. A RCA product DNA may be used as the double stranded concatemer DNA for the methods.

IPC Classes  ?

  • C12P 21/00 - Preparation of peptides or proteins
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

19.

Ethylene oxide treatment indicator, label and method of use

      
Application Number 16078749
Grant Number 11696969
Status In Force
Filing Date 2017-02-28
First Publication Date 2019-02-14
Grant Date 2023-07-11
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor Tatnell, Peter James

Abstract

The present invention provides an indicator useful in confirming successful sterilisation and/or nucleic acid decontamination by ethylene oxide (EtO) treatment. The invention also provides a label comprising said indicator and methods for use of the indicator and label in a method of EtO treatment.

IPC Classes  ?

  • A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
  • A61L 2/20 - Gaseous substances, e.g. vapours
  • G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators

20.

Amplification and detection of nucleic acids

      
Application Number 16036430
Grant Number 11173490
Status In Force
Filing Date 2018-07-16
First Publication Date 2019-01-10
Grant Date 2021-11-16
Owner
  • University of Washington (USA)
  • Global Life Sciences Solutions Operations UK Ltd. (United Kingdom)
Inventor
  • Moore, David Roger
  • Misner, Matthew Jeremiah
  • Burns, Andrew Arthur Paul
  • Bishop, Joshua
  • Lafleur, Lisa K.
  • Wheeler, Maxwell

Abstract

The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

21.

Methods for electroelution of biomolecules

      
Application Number 16012147
Grant Number 11033859
Status In Force
Filing Date 2018-06-19
First Publication Date 2018-12-20
Grant Date 2021-06-15
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Nelson, John Richard
  • Spooner, Patrick Mccoy
  • Lenigk, Ralf
  • Wood, Nicole Lea
  • Zhu, Li
  • Galligan, Craig Patrick

Abstract

A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.

IPC Classes  ?

  • B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

22.

Display screen with a graphical user interface

      
Application Number 29575394
Grant Number D0831683
Status In Force
Filing Date 2016-08-24
First Publication Date 2018-10-23
Grant Date 2018-10-23
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Ghosh, Pratik

23.

Display screen with a graphical user interface

      
Application Number 29575395
Grant Number D0831684
Status In Force
Filing Date 2016-08-24
First Publication Date 2018-10-23
Grant Date 2018-10-23
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Ghosh, Pratik

24.

Method and apparatus for isolating nucleic acids

      
Application Number 15985771
Grant Number 10683496
Status In Force
Filing Date 2018-05-22
First Publication Date 2018-09-20
Grant Date 2020-06-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Chen, Lin
  • Zhang, Bing
  • Hochleitner, Klaus
  • Hou, Rong
  • Wang, Yanju

Abstract

A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
  • C07H 1/06 - Separation; Purification
  • C07H 1/08 - Separation; Purification from natural products
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

25.

METHOD FOR IDENTIFYING EXPRESSION DISTINGUISHERS IN BIOLOGICAL SAMPLES

      
Application Number 15659359
Status Pending
Filing Date 2017-07-25
First Publication Date 2018-09-06
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Newberg, Lee Aaron
  • Kodira, Chinnappa

Abstract

The present techniques provide techniques for determining gene expression distinguishers of biological samples using expression data that comprises signal intensity of signal generators with binding specificity to target molecules. Multiple samples may be analyzed to determine gene expression distinguishers that may be used for identifying cell types or understanding the mechanism of disease progression.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G06F 19/24 - for machine learning, data mining or biostatistics, e.g. pattern finding, knowledge discovery, rule extraction, correlation, clustering or classification
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G06F 19/20 - for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation

26.

Method and kit for analyte detection

      
Application Number 15753343
Grant Number 10907148
Status In Force
Filing Date 2016-08-18
First Publication Date 2018-08-30
Grant Date 2021-02-02
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James

Abstract

The present invention relates to a method and kit for analyte detection. More precisely the invention relates to a method of detecting an analyte, comprising storing short single stranded nucleic acids (10-100 nt), such as aptamers and micro RNA, on a solid support at ambient temperature; and subsequent amplification of said nucleic acids for detection of analyte(s).

IPC Classes  ?

  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase

27.

Ligase-assisted nucleic acid circularization and amplification

      
Application Number 15949061
Grant Number 10655167
Status In Force
Filing Date 2018-04-09
First Publication Date 2018-08-09
Grant Date 2020-05-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Kvam, Erik Leeming
  • Nelson, John Richard

Abstract

Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any intervening purification steps. The single-stranded DNA circle is generated via a template-independent single-stranded DNA ligation. Whole-genome amplification of linear chromosomal DNA in a single tube using ligation-assisted DNA amplification is also provided.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6869 - Methods for sequencing

28.

Display screen with a graphical user interface

      
Application Number 29575396
Grant Number D0822708
Status In Force
Filing Date 2016-08-24
First Publication Date 2018-07-10
Grant Date 2018-07-10
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Ghosh, Pratik

29.

Sample collection and transfer device

      
Application Number 15905226
Grant Number 10675622
Status In Force
Filing Date 2018-02-26
First Publication Date 2018-07-05
Grant Date 2020-06-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lenigk, Ralf
  • Finehout, Erin Jean
  • Wang, Xuefeng

Abstract

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 3/02 - Burettes; Pipettes

30.

Biological sample collectors and handling thereof

      
Application Number 15562696
Grant Number 10955321
Status In Force
Filing Date 2016-03-23
First Publication Date 2018-03-01
Grant Date 2021-03-23
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth
  • Norey, Christopher George
  • Pierce, Alan Stuart
  • John, Robert

Abstract

Disclosed is a biological sample collector 500 comprising a solid support 12 having plural discrete areas (22, 24, 26, 28 FIG. 1) for accepting a biological sample, each area being chemically differentiated, for example by having a different chemical treatment sorbed onto the solid support. An envelope 530 encloses the solid support. A cover portion 520 can cover the biological sample after collection to prevent infection. UV light can be applied to the collected sample to reduce the risk of infection.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

31.

Devices for separation of particulates, associated methods and systems

      
Application Number 15209411
Grant Number 10518196
Status In Force
Filing Date 2016-07-13
First Publication Date 2018-01-04
Grant Date 2019-12-31
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Galligan, Craig Patrick
  • Grossman, Gregory Andrew
  • Kvam, Erik Leeming
  • Duthie, Robert Scott
  • Rigby, Kenneth Wayne
  • Smigelski, Jr., Paul Michael
  • Cotero, Victoria Eugenia
  • Castle, Jason William
  • Burczak, John Donald
  • Rothman, James Edward

Abstract

A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.

IPC Classes  ?

  • B01D 21/00 - Separation of suspended solid particles from liquids by sedimentation
  • B01D 21/24 - Feed or discharge mechanisms for settling tanks
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/40 - Concentrating samples
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler
  • B01D 17/02 - Separation of non-miscible liquids
  • B01D 21/02 - Settling tanks
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C02F 1/48 - Treatment of water, waste water, or sewage with magnetic or electric fields
  • C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
  • C02F 101/32 - Hydrocarbons, e.g. oil

32.

High capacity redox electrodes and their use in cell lysis

      
Application Number 15532233
Grant Number 11402349
Status In Force
Filing Date 2015-12-03
First Publication Date 2017-12-21
Grant Date 2022-08-02
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Peters, Andrea Jeannine
  • Stecher, Thomas Elliot
  • Galligan, Craig Patrick
  • Puleo, Christopher Michael
  • Lenigk, Ralf

Abstract

The present disclosure relates to the manufacture and use of redox electrodes and their use in cell lysis. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 Volts.

IPC Classes  ?

  • G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • H01G 9/042 - Electrodes characterised by the material
  • H01G 9/22 - Devices using combined reduction and oxidation, e.g. redox arrangement or solion
  • H01G 11/02 - Hybrid capacitors, i.e. capacitors having different positive and negative electrodes; Electric double-layer [EDL] capacitors; Processes for the manufacture thereof or of parts thereof using combined reduction-oxidation reactions, e.g. redox arrangement or solion
  • H01G 11/28 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features arranged or disposed on a current collector; Layers or phases between electrodes and current collectors, e.g. adhesives
  • H01G 11/48 - Conductive polymers
  • H01G 11/86 - Processes for the manufacture of hybrid or EDL capacitors, or components thereof specially adapted for electrodes
  • G01N 27/453 - Cells therefor
  • H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds

33.

Devices, methods and systems for collecting waste from a bioreactor

      
Application Number 15529567
Grant Number 10227554
Status In Force
Filing Date 2015-12-15
First Publication Date 2017-11-23
Grant Date 2019-03-12
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Janas, Michelle Louise

Abstract

The invention relates to devices, methods and systems for collecting and solidifying waste material from bioreactor cell cultures in order to facilitate waste disposal. The invention finds particular utility in mammalian cell culture applications. A transverse wall divides the interior of a waste bag into two chambers, the first chamber containing an inlet receiving waste liquid from a bioreactor, the second chamber containing an absorbent material to solidify the liquid into a gel. The transverse wall acts to direct the flow of waste media into the second chamber where it is converted into a gel and further prevents the inlet from being blocked by any gel or particulate materials. Methods and uses regarding this invention are described.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology

34.

Methods and reagents for reverse-transcription polymerase chain reaction

      
Application Number 15533714
Grant Number 10968478
Status In Force
Filing Date 2015-12-18
First Publication Date 2017-11-09
Grant Date 2021-04-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Yarunin, Alexander
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Fullerton, Rebecca Ngaire

Abstract

The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a polar aprotic solvent; a serum albumin, and a polyol.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C07H 1/00 - Processes for the preparation of sugar derivatives
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

35.

Cell-free protein expression using rolling circle amplification product

      
Application Number 15145838
Grant Number 10077459
Status In Force
Filing Date 2016-05-04
First Publication Date 2017-11-09
Grant Date 2018-09-18
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.

IPC Classes  ?

  • C12P 21/00 - Preparation of peptides or proteins
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression

36.

Composition and method for imaging stem cells

      
Application Number 15631124
Grant Number 10920287
Status In Force
Filing Date 2017-06-23
First Publication Date 2017-10-19
Grant Date 2021-02-16
Owner
  • Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
  • The Board of Trustees of the Leland Stanford Junior University (USA)
Inventor
  • Bhaumik, Srabani
  • Gambhir, Sanjiv Sam
  • Paulmurugan, Ramasamy
  • Yaghoubi, Shahriar
  • Ahn, Byeong-Cheol
  • Parashurama, Natesh

Abstract

An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more of the cells differentiate or dedifferentiate. Methods and kits for imaging and monitoring stem cells comprising the expression vector are also provided.

IPC Classes  ?

  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

37.

Analyte detection on a solid support by nucleic acid amplification coupled to an immunoassay

      
Application Number 15529597
Grant Number 11008604
Status In Force
Filing Date 2015-12-08
First Publication Date 2017-09-14
Grant Date 2021-05-18
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Lamerton, Kathryn Louise
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James

Abstract

Embodiments of the invention provides a method for detection of at least one analyte derived from a sample, comprising the steps of: a) depositing the sample on a surface of a solid support; b) transferring at least a portion of the solid support to a receptacle suitable for performing a specific binding assay for one or more analytes of interest; c) optionally washing the portion; d) adding a single specific binding partner for each analyte of interest to the receptacle, the binding partner being labelled with an oligonucleotide sequence; e) mixing the portion with nucleic acid amplification reagents; f) amplifying the oligonucleotide sequence; and g) detecting amplified nucleic acid. The invention also provides a kit for use with the method for detection of at least one analyte derived from a sample.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • C12Q 1/6804 - Nucleic acid analysis using immunogens
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6851 - Quantitative amplification

38.

Method and composition for biomolecule stabilization

      
Application Number 15429760
Grant Number 10590408
Status In Force
Filing Date 2017-02-10
First Publication Date 2017-08-24
Grant Date 2020-03-17
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Ashman, Elizabeth Mary

Abstract

The present invention relates to biomolecule stabilization to provide biomolecules, such as sensitive polymerases, in a convenient ready-to-go format. The invention provides a method and composition in which non-ionic surfactant or detergents of the polyoxyethylene cetyl ether family are used, preferably a Brij reagent or a combination of Brij reagents.

IPC Classes  ?

  • C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12Q 1/686 - Polymerase chain reaction [PCR]

39.

Screening and monitoring the progression of type 2 diabetes by the molecular identification of human gut flora using FTA as a faecal collection device

      
Application Number 15326382
Grant Number 10982290
Status In Force
Filing Date 2015-07-23
First Publication Date 2017-07-27
Grant Date 2021-04-20
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James
  • Morrison, Matthew Sam
  • Pierce, Alan Stuart

Abstract

Disclosed is a method for detecting and quantifying gut flora derived from human faeces, comprising acquiring a solid support containing human faeces; optionally amplifying nucleic acid from the human faeces; and detecting and quantifying the presence of gut flora of interest. Also disclosed is a method for assessing whether a person has type-2 diabetes as well as a kit for detecting and quantifying gut flora from human faeces, comprising a solid support for collecting human faeces; and primer pairs for amplifying 16S rRNA sequence from bacteria of interest.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/10 - Enterobacteria
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • C12Q 1/06 - Quantitative determination
  • A61K 38/00 - Medicinal preparations containing peptides
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

40.

Method and device for collection and amplification of circulating nucleic acids

      
Application Number 15463943
Grant Number 11142758
Status In Force
Filing Date 2017-03-20
First Publication Date 2017-07-27
Grant Date 2021-10-12
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Nelson, John Richard
  • Grossmann, Gregory Andrew
  • Heller, Ryan Charles
  • Finehout, Erin Jean
  • Puleo, Christopher Michael
  • Waters, William Patrick

Abstract

Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

41.

Sample collection and transfer device

      
Application Number 15326412
Grant Number 10350592
Status In Force
Filing Date 2015-07-20
First Publication Date 2017-07-20
Grant Date 2019-07-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lenigk, Ralf
  • Finehout, Erin Jean
  • Wang, Xuefeng

Abstract

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • A61B 5/15 - Devices for taking samples of blood
  • G01N 1/14 - Suction devices, e.g. pumps; Ejector devices
  • B01L 3/02 - Burettes; Pipettes

42.

Direct nucleic acid amplification kit, reagent and method

      
Application Number 15432476
Grant Number 10907201
Status In Force
Filing Date 2017-02-14
First Publication Date 2017-06-01
Grant Date 2021-02-02
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey K.
  • Tatnell, Peter J.
  • Lamerton, Kathryn L.

Abstract

The present invention relates to compositions, methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. The dried reagent composition of the invention can be used for easy processing and amplification of nucleic acid samples.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

43.

Oligonucleotide data storage on solid supports

      
Application Number 15102209
Grant Number 11931713
Status In Force
Filing Date 2014-11-26
First Publication Date 2017-06-01
Grant Date 2024-03-19
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James
  • Stone, Robert

Abstract

A data storage medium is disclosed comprising a solid support matrix including an optional stabilising reagent or reagents in a dry form, for use as a support for artificially synthesised oligonucleotide sequences encoded with data. Preferably the matrix is fibrous (for example cellulose, or glass, fibres) formed into a support of sufficient strength to hold the oligonucleotide sequences. The stabilising reagents are preferably a combination of a weak base, and a chelating agent, optionally, uric acid or a urate salt, and optionally an anionic surfactant.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]

44.

Device and method of collection for RNA viruses

      
Application Number 14945483
Grant Number 10000742
Status In Force
Filing Date 2015-11-19
First Publication Date 2017-05-25
Grant Date 2018-06-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Duthie, Robert Scott
  • Nelson, John Richard

Abstract

The present disclosure generally relates to a method and device for inactivation and dry storage, under ambient conditions, of a biological sample containing RNA virus. Methods for collecting and recovering RNA from a biological sample and subsequent analysis for a virus are also provided.

IPC Classes  ?

  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

45.

Solid phase isothermal amplification

      
Application Number 15419560
Grant Number 10443094
Status In Force
Filing Date 2017-01-30
First Publication Date 2017-05-18
Grant Date 2019-10-15
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard
  • Patel, Paresh Lakhubhai
  • Wakefield, Alison Myfanwy
  • Capper, Stephen James
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth

Abstract

m) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

46.

Device and method for cell nuclei preparation

      
Application Number 15317039
Grant Number 10370649
Status In Force
Filing Date 2015-06-17
First Publication Date 2017-05-04
Grant Date 2019-08-06
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kenrick, Michael Kenneth
  • Seymour, Geraint

Abstract

The present invention relates to the field of nucleic acid collection and storage, and in particular to the collection and long-term storage of nuclei. The invention provides a device and method which can be used to capture and store nuclei at ambient temperatures allowing the subsequent isolation of nucleic acids by passive washing with a wash buffer. The present invention also provides a kit including the device of the invention suitable for carrying out the method of the invention.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

47.

Isothermal amplification under low salt condition

      
Application Number 15408509
Grant Number 10597691
Status In Force
Filing Date 2017-01-18
First Publication Date 2017-05-04
Grant Date 2020-03-24
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard
  • Patel, Paresh Lakhubhai
  • Wakefield, Alison Myfanwy
  • Capper, Stephen James

Abstract

m) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/6844 - Nucleic acid amplification reactions

48.

Biological sample collection device

      
Application Number 15349638
Grant Number 10271825
Status In Force
Filing Date 2016-11-11
First Publication Date 2017-05-04
Grant Date 2019-04-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Pierce, Alan Stuart
  • Potts, Cheryl Louise
  • Stubbs, Simon Laurence John
  • Treharne, David Gwyn

Abstract

Methods of using a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • A61B 5/15 - Devices for taking samples of blood

49.

Processed biological sample storage

      
Application Number 15119065
Grant Number 10392651
Status In Force
Filing Date 2015-02-20
First Publication Date 2017-02-23
Grant Date 2019-08-27
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Moran, Nina

Abstract

A fluidic device is disclosed for processing a biological sample in order to extract nucleic acids contained in said sample and for subsequently amplifying said extracted nucleic acids, said device including a processed sample storage archive area 10 comprising an absorbent solid substrate 14 treated with at least one nucleic acid stabilizing reagent or reagent mix, said substrate allowing the generally dry and stabilized storage of said extracted and/or amplified nucleic acids, for example for long term storage of biological samples recovered forensically.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • B01L 9/00 - Supporting devices; Holding devices

50.

Amplification and detection of nucleic acids

      
Application Number 14807497
Grant Number 10040069
Status In Force
Filing Date 2015-07-23
First Publication Date 2017-01-26
Grant Date 2018-08-07
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Moore, David Roger
  • Misner, Matthew Jeremiah
  • Burns, Andrew Arthur Paul
  • Bishop, Joshua
  • Lafleur, Lisa K.
  • Wheeler, Maxwell

Abstract

The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

51.

Substrates and methods for collection, stabilization and elution of biomolecules

      
Application Number 15285986
Grant Number 10625242
Status In Force
Filing Date 2016-10-05
First Publication Date 2017-01-26
Grant Date 2020-04-21
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kovacs, Ernest William
  • Mondello, Frank John
  • Kvam, Erik Leeming
  • Li, Bing

Abstract

A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.

IPC Classes  ?

  • C12N 9/38 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-galactose-glycoside bonds, e.g. beta-galactosidase
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
  • C07K 1/16 - Extraction; Separation; Purification by chromatography
  • C07K 1/14 - Extraction; Separation; Purification
  • C07K 14/54 - Interleukins (IL)
  • C07K 14/525 - Tumour necrosis factor (TNF)
  • C07K 14/545 - IL-1
  • C07K 14/775 - Apolipopeptides
  • B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/32 - Impregnating or coating

52.

Microfluidic devices and arrangements for introducing reagents and biological samples to such devices

      
Application Number 15121147
Grant Number 10252265
Status In Force
Filing Date 2015-02-20
First Publication Date 2016-12-22
Grant Date 2019-04-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth
  • Seymour, Geraint

Abstract

A microfluidic device 100 is disclosed comprising a body 112 including a biological sample S and/or reagent R receiving slot 122. The sample and reagent are carried on a solid support 10. The device 100 includes two punch assemblies 130 for removing portions of the solid support 10 and delivering them, together with the sample and/or reagent(s), to a receiving chamber 126 for subsequent processing. The device can be used for various assays including those which require just the addition of water in the reaction chamber with no pre-treatment of sample prior delivery into the chamber.

IPC Classes  ?

  • G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/28 - Preparing specimens for investigation

53.

Method and apparatus for isolating nucleic acids

      
Application Number 15231082
Grant Number 10000751
Status In Force
Filing Date 2016-08-08
First Publication Date 2016-11-24
Grant Date 2018-06-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Chen, Lin
  • Zhang, Bing
  • Hochleitner, Klaus
  • Hou, Rong
  • Wang, Yanju

Abstract

A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
  • C07H 1/06 - Separation; Purification
  • C07H 1/08 - Separation; Purification from natural products
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

54.

MICROFLUIDIC DEVICES AND ARRANGEMENTS FOR SUPPLYING SUCH DEVICES WITH REAGENTS AND BIOLOGICAL SAMPLES

      
Application Number 15030994
Status Pending
Filing Date 2014-10-08
First Publication Date 2016-10-20
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Stubbs, Simon Laurence John
  • Tatnell, Peter James
  • Seymour, Geraint
  • Potts, Cheryl Louise
  • Pierce, Alan Stuart
  • Powell, David
  • Wakefield, Alison Myfanwy

Abstract

Disclosed is a microfluidic device including a reagent supply apparatus comprising: a solid support 12 formed preferably from cellulose fibrous material having a porosity which allows liquid flow through the material; at least one generally dry reagent 16 stored on a surface of the support at a regent location or locations; the support further being suitable for storing biological sample material 17 in a dry state at a sample location or locations, spaced from the reagent location or locations.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

55.

Controlled transfer biological sample collection devices and methods of using such devices

      
Application Number 15101113
Grant Number 10085726
Status In Force
Filing Date 2014-11-25
First Publication Date 2016-10-20
Grant Date 2018-10-02
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Potts, Cheryl Louise
  • Tatnell, Peter James
  • Seymour, Geraint
  • Pierce, Alan Stuart
  • Smith, Michael John
  • Ogden, Samantha Jane
  • Williams, Neil John
  • Burrows, Christopher
  • Evans, Jared William Harris
  • Bryant, Ashley Edward
  • Sweeney, Sean Robert

Abstract

A controlled transfer biological sample material collection device is disclosed which comprises: a body; and a sample collection member for collecting the biological sample material (not shown), the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position (shown in FIG. 8) where collection of a biological sample is possible, to a transfer position (shown in FIG. 9) which effects transfer of at least a portion of the collected sample to said medium. The device is characterized in that the body slideably supports the sample collection member, and in that the body or collection member include a ramp-like projection portion (116 FIG. 10) operable to force the collection member into the transfer position against the medium and to effect said transfer as the collection member slides within the body.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • B65D 81/00 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/24 - Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganism
  • G01N 1/30 - Staining; Impregnating

56.

Methods and systems for processing samples on porous substrates

      
Application Number 14992859
Grant Number 10365190
Status In Force
Filing Date 2016-01-11
First Publication Date 2016-09-29
Grant Date 2019-07-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Shoemaker, Philip Alexander
  • Griffin, Weston Blaine
  • Finehout, Erin Jean
  • Wang, Xuefeng
  • Shaikh, Kashan Ali
  • Goddard, Greg Darryl

Abstract

Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 1/40 - Concentrating samples
  • G01N 30/72 - Mass spectrometers
  • G01N 1/34 - Purifying; Cleaning
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
  • G01N 30/06 - Preparation

57.

Isothermal amplification using oligocation-conjugated primer sequences

      
Application Number 15177149
Grant Number 09920359
Status In Force
Filing Date 2016-06-08
First Publication Date 2016-09-29
Grant Date 2018-03-20
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard

Abstract

Provided herein are methods and kits for isothermal nucleic acid amplifications that use an oligocation-oligonucleotide conjugate primer for amplifying a target nucleic acid to generate amplicons. Isothermal DNA amplification methods that employ a strand displacing DNA polymerase and polyamine-oligonucleotide conjugate primer are also provided.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes

58.

Solid medium for the storage of biological material

      
Application Number 15175478
Grant Number 10196675
Status In Force
Filing Date 2016-06-07
First Publication Date 2016-09-22
Grant Date 2019-02-05
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • James, Martin D.
  • Horton, Jeffrey K.
  • Tatnell, Peter J.

Abstract

This invention relates to flat solid media for the storage of samples of biological materials and methods of analyzing biomolecules contained within the samples following storage. In particular, the invention relates to the storage and further analysis of biomolecules present in the biological materials, such as proteins, enzymes and nucleic acids. The invention finds particular utility in the dry, room temperature storage of biological materials.

IPC Classes  ?

  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • A01N 1/02 - Preservation of living parts
  • C12N 9/22 - Ribonucleases
  • C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

59.

Biological sample material collection

      
Application Number 14913248
Grant Number 10274402
Status In Force
Filing Date 2014-08-07
First Publication Date 2016-07-14
Grant Date 2019-04-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Smith, Michael John
  • Tatnell, Peter James
  • Goren, Leonard

Abstract

a, said tip at least being formed from a fibrous material mixed with a liquid to form a pulp, said pulp being solidified to form the shape of the tip.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
  • B29C 44/02 - Shaping by internal pressure generated in the material, e.g. swelling or foaming for articles of definite length, i.e. discrete articles
  • B29C 44/10 - Applying counter-pressure during expanding
  • A61F 13/38 - Swabs having a stick-type handle
  • B29K 105/04 - Condition, form or state of moulded material cellular or porous
  • B29K 105/16 - Fillers
  • B29K 511/00 - Use of natural products or their composites, not provided for in groups , as filler
  • B29L 31/00 - Other particular articles
  • A61F 13/53 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium

60.

Mutant endonuclease V enzymes and applications thereof

      
Application Number 15048624
Grant Number 10100292
Status In Force
Filing Date 2016-02-19
First Publication Date 2016-06-09
Grant Date 2018-10-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Grossman, Gregory Andrew
  • Sekher, Anuradha

Abstract

Provided herein are mutant endonuclease V enzymes that are capable of nicking an inosine-containing DNA sequence. Nucleic acid assays and agents that employ such mutant endonuclease V enzymes to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of a target DNA are also described.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 9/22 - Ribonucleases
  • C12Q 1/6858 - Allele-specific amplification
  • C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
  • C07K 1/00 - General processes for the preparation of peptides
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

61.

Method for nuclei storage

      
Application Number 14907111
Grant Number 10087437
Status In Force
Filing Date 2014-07-23
First Publication Date 2016-06-02
Grant Date 2018-10-02
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Kenrick, Michael Kenneth

Abstract

A method of performing data management in a high-speed data environment. The method includes collecting time-series information including multiple data types captured concurrently, and storing the collected time-series information in a process historian with organization, the organization occurring when the multiple data types are captured.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

62.

Porous membranes with a polymer grafting, methods and uses thereof

      
Application Number 14548383
Grant Number 11754563
Status In Force
Filing Date 2014-11-20
First Publication Date 2016-05-26
Grant Date 2023-09-12
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Li, Bing
  • Bales, Brian Christopher
  • Moore, David Roger
  • Nichols, Jason Michael
  • Olsen, Cathryn Ellen
  • Alberts, William Christopher
  • Mondello, Frank John

Abstract

A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/548 - Carbohydrates, e.g. dextran

63.

Controlled transfer biological sample collection devices and methods of using such devices

      
Application Number 14894682
Grant Number 10150118
Status In Force
Filing Date 2014-05-14
First Publication Date 2016-04-21
Grant Date 2018-12-11
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Tortorella, Stevan Paul
  • Seymour, Geraint
  • Potts, Cheryl Louise
  • Pierce, Alan Stuart
  • Ogden, Samantha Jane
  • Williams, Neil John

Abstract

A controlled transfer biological sample material collection device is disclosed which includes a body and a sample collection member for collecting the biological sample material, the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position where collection of a biological sample is possible, to a transfer position which effects transfer of at least a portion of the collected sample to said medium. The body of the device slideably supports the sample collection member, and the body or collection member includes a ramp-like projection portion operable to force the collection member into the transfer position against the medium and to effect the transfer as the collection member slides within the body.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
  • G01N 1/02 - Devices for withdrawing samples

64.

Sample holder for analysis of solid biological samples

      
Application Number 14888225
Grant Number 10744499
Status In Force
Filing Date 2013-04-30
First Publication Date 2016-03-17
Grant Date 2020-08-18
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Moran, Nina
  • Smith, Michael John
  • Seymour, Geraint
  • Ogden, Samantha Jane
  • Goren, Leonard

Abstract

A biological sample holder for holding a solid phase sample, including a handle, and a seal area suitable for being received in an opening of a sample receiving chamber of a cassette, mountable to a sample analysis instrument. The holder further includes a stem connected to the seal and a sample retainer connected to the stem for retaining solids in the retainer, the sample retainer including a perforated wall region for allowing fluids to pass through the wall but preventing the solid phase sample from passing through the wall.

IPC Classes  ?

  • B01L 9/00 - Supporting devices; Holding devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • G01N 1/40 - Concentrating samples

65.

Solid matrix for the storage of biological samples

      
Application Number 14843262
Grant Number 10501736
Status In Force
Filing Date 2015-09-02
First Publication Date 2016-03-03
Grant Date 2019-12-10
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • O'Malley, Hugh
  • Johnson, Barry

Abstract

The present invention relates to a method for storage and subsequent lysis of a sample in which the sample is immobilized on a solid support. The solid matrix is embedded with a low concentration of both a chaotropic salt and a surfactant which act synergistically to efficiently store and lyse a biological sample.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

66.

Ligase-assisted nucleic acid circularization and amplification

      
Application Number 14933275
Grant Number 09938568
Status In Force
Filing Date 2015-11-05
First Publication Date 2016-02-25
Grant Date 2018-04-10
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Kvam, Erik Leeming
  • Nelson, John Richard

Abstract

Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any intervening purification steps. The single-stranded DNA circle is generated via a template-independent single-stranded DNA ligation. Whole-genome amplification of linear chromosomal DNA in a single tube using ligation-assisted DNA amplification is also provided.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

67.

Device for separation and collection of plasma

      
Application Number 14712290
Grant Number 10335078
Status In Force
Filing Date 2015-05-14
First Publication Date 2016-02-04
Grant Date 2019-07-02
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Griffin, Weston Blaine
  • Finehout, Erin Jean
  • Mao, Ying

Abstract

A method for separating and collecting cell-free plasma by finger stick that minimizes contamination with genomic DNA from a donor. The method comprising placing a tourniquet on one of the digits of the donor's finger to apply pressure, lancing the digit to create an incision in the digit, and collecting blood from the incision from the incision site. The collected blood is placed on a separation membrane wherein the separation membrane is in contact with a collection membrane and both the separation and collection membrane are inserted into a substrate configured to provide overlap between the membranes. A kit and instructions for carrying out the method is also provided.

IPC Classes  ?

  • A61B 5/15 - Devices for taking samples of blood
  • A61B 5/151 - Devices for taking samples of blood specially adapted for taking samples of capillary blood, e.g. by lancets
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

68.

Device for separation and collection of plasma

      
Application Number 14450585
Grant Number 09950321
Status In Force
Filing Date 2014-08-04
First Publication Date 2016-02-04
Grant Date 2018-04-24
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Griffin, Weston Blaine
  • Finehout, Erin Jean
  • Mao, Ying

Abstract

A substrate for positioning a separation membrane and a collection membrane for separating and collecting plasma is disclosed. The substrate includes an inner flexure disposed proximate to a first peripheral portion of the substrate and an outer flexure disposed surrounding at least a portion of the inner flexure. The inner flexure is formed from a plurality of first slots in the substrate and the outer flexure is formed from a plurality of second slots in the substrate.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01D 63/08 - Flat membrane modules
  • B01D 61/18 - Apparatus therefor

69.

Sample collection and transfer device

      
Application Number 14340693
Grant Number 09901922
Status In Force
Filing Date 2014-07-25
First Publication Date 2016-01-28
Grant Date 2018-02-27
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lenigk, Ralf
  • Finehout, Erin Jean
  • Wang, Xuefeng

Abstract

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material, and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.

IPC Classes  ?

  • G01N 1/18 - Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 3/02 - Burettes; Pipettes

70.

Sample collection and transfer device

      
Application Number 14341074
Grant Number 09480981
Status In Force
Filing Date 2014-07-25
First Publication Date 2016-01-28
Grant Date 2016-11-01
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lenigk, Ralf
  • Finehout, Erin Jean
  • Wang, Xuefeng

Abstract

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.

IPC Classes  ?

  • B01L 3/02 - Burettes; Pipettes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

71.

Biological sample collection device

      
Application Number 14867268
Grant Number 09492145
Status In Force
Filing Date 2015-09-28
First Publication Date 2016-01-21
Grant Date 2016-11-15
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Pierce, Alan Stuart
  • Potts, Cheryl Louise
  • Stubbs, Simon Laurence John
  • Treharne, David Gwyn

Abstract

Methods of using a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

72.

Methods for one step nucleic acid amplification of non-eluted samples

      
Application Number 14774259
Grant Number 10053686
Status In Force
Filing Date 2014-03-14
First Publication Date 2016-01-21
Grant Date 2018-08-21
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kenrick, Michael Kenneth
  • Emery, Aidan Mark
  • Allan, Fiona Elizabeth
  • Webster, Bonnie Lee
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

The present invention relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. For easy processing and amplification of nucleic acid samples, the samples are bound to a solid support and used directly, without purification, in a nucleic acid amplification reaction such as the polymerase chain reaction (PCR).

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

73.

Methods for capturing nucleic acids

      
Application Number 14566865
Grant Number 10870845
Status In Force
Filing Date 2014-12-11
First Publication Date 2016-01-07
Grant Date 2020-12-22
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Nelson, John Richard
  • Li, Bing

Abstract

A method is provided herein, wherein the method of capturing a target nucleic acid, comprises applying a nucleic acid capture probe to a capture zone of a needs definition, wherein the nucleic acid capture probe having a first molecular weight comprises at least a sequence that is complimentary to at least a portion of the target nucleic acid sequence and the nucleic acid capture probe is substantially immobilized at the capture zone of the substrate. The method further comprises applying a sample comprising the target nucleic acid having a second molecular weight to a sample application zone of the substrate; wherein the sample comprising the target nucleic acid flows across a length of the substrate from the sample application zone to the capture zone by lateral flow, and the target nucleic acid is captured by the nucleic acid capture probes by hybridization to the capture zone.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

74.

Method, substrate and device for separating nucleic acids

      
Application Number 14321160
Grant Number 10472620
Status In Force
Filing Date 2014-07-01
First Publication Date 2016-01-07
Grant Date 2019-11-12
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nelson, John Richard
  • Moore, David Roger
  • Duthie, Robert Scott
  • Misner, Matthew Jeremiah
  • Grossmann, Gregory Andrew
  • Dees, Elizabeth Marie
  • Spooner, Patrick Mccoy
  • Kvam, Erik Leeming
  • Burns, Andrew Arthur Paul
  • Watkins, Vicki Herzl

Abstract

A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; and flowing a nucleic acid amplification reaction mixture across a length of the substrate through the sample application zone to amplify the target nucleic acid forming a nucleic acid amplification product; wherein the target nucleic acid having a first molecular weight is substantially immobilized at the sample application zone and wherein the amplification product having a second molecular weight migrates away from the sample application zone. An associated device is also provided.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

75.

Methods for amplifying nucleic acids on substrates

      
Application Number 14321235
Grant Number 09593368
Status In Force
Filing Date 2014-07-01
First Publication Date 2016-01-07
Grant Date 2017-03-14
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Puleo, Christopher Michael
  • Spooner, Patrick Mccoy

Abstract

A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; applying an aqueous buffer to the sample application zone of the substrate to washes away one or more inhibitors present on the sample application zone; and applying an isothermal nucleic acid amplification reaction mixture to the sample application zone to amplify the target nucleic acid to form a nucleic acid amplification product. The target nucleic acid having a first molecular weight is substantially immobilized at the sample application zone and wherein the amplification product having a second molecular weight.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

76.

Cell culturing and/or biomanufacturing system

      
Application Number 14767141
Grant Number 09926525
Status In Force
Filing Date 2013-02-11
First Publication Date 2015-12-24
Grant Date 2018-03-27
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Norey, Christopher George
  • Janas, Michelle Louise
  • Patterson, Anthony
  • Crawley, Adrian

Abstract

The present invention relates to systems and methods for optimising the usage of laboratory and cell culturing space for cell culture and biomanufacturing. The invention provides a system and method that can be used to provide a plurality of workstations and/or storage bays for bioreactors in cell culturing and/or biomanufacturing facilities.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

77.

Method and apparatus for isolating nucleic acids

      
Application Number 14364436
Grant Number 09441220
Status In Force
Filing Date 2012-12-20
First Publication Date 2015-10-22
Grant Date 2016-09-13
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Chen, Lin
  • Shang, Bing
  • Hochleitner, Klaus
  • Hou, Rong
  • Wang, Yanju

Abstract

A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
  • C07H 1/06 - Separation; Purification
  • C07H 1/08 - Separation; Purification from natural products

78.

Methods for One Step Nucleic Acid Amplification of Non-Eluted Samples

      
Application Number 14441569
Status Pending
Filing Date 2013-11-06
First Publication Date 2015-10-22
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Pierce, Alan Stuart
  • Ashman, Elizabeth

Abstract

The present invention relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. For easy processing and amplification of nucleic acid samples, the samples are bound to a solid support and used directly, without purification, in a nucleic acid amplification reaction such as the polymerase chain reaction (PCR).

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

79.

Method for cell differentiation

      
Application Number 14225740
Grant Number 09404086
Status In Force
Filing Date 2014-03-26
First Publication Date 2015-10-01
Grant Date 2016-08-02
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Czysz, Katarzyna Anna

Abstract

The present invention relates to the field of cell biology, in particular to methods for differentiating pluripotent stem cells. The invention provides methods for differentiating primate pluripotent stem cells into cells of all three germinal layers. In particular, methods for differentiating primate pluripotent stem cells into the definitive endoderm are provided.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

80.

Isothermal amplification under low salt condition

      
Application Number 14225887
Grant Number 09587263
Status In Force
Filing Date 2014-03-26
First Publication Date 2015-10-01
Grant Date 2017-03-07
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard
  • Patel, Paresh Lakhubhai
  • Wakefield, Alison Myfanwy
  • Capper, Stephen James

Abstract

m) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

81.

Biological sample collection device

      
Application Number 14671295
Grant Number 09168029
Status In Force
Filing Date 2015-03-27
First Publication Date 2015-09-10
Grant Date 2015-10-27
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Pierce, Alan Stuart
  • Potts, Cheryl Louise
  • Stubbs, Simon Laurence John
  • Treharne, David Gwyn

Abstract

Methods of using a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter.

IPC Classes  ?

  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

82.

Porous membrane patterning technique

      
Application Number 14194340
Grant Number 09415349
Status In Force
Filing Date 2014-02-28
First Publication Date 2015-09-03
Grant Date 2016-08-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nichols, Jason Michael
  • Misner, Matthew Jeremiah
  • Zhou, Hongyi

Abstract

A porous membrane patterning technique is provided. In one embodiment, a porous membrane may be patterned via printing on the porous membrane with a solvent such that the porous membrane collapses where the solvent is applied. In another embodiment, a patterned porous membrane may be formed by casting a solution including at least components of the porous membrane into voids of a casting plate or stencil, removing the casting plate, and letting the remaining components go through a phase inversion process to form porous membrane regions.

IPC Classes  ?

  • B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
  • B05D 3/04 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
  • B29C 37/02 - Deburring or deflashing
  • B01D 39/00 - Filtering material for liquid or gaseous fluids
  • B01D 69/12 - Composite membranes; Ultra-thin membranes
  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B29C 39/00 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
  • B29C 39/02 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
  • B29C 39/44 - Measuring, controlling or regulating
  • B29C 67/00 - Shaping techniques not covered by groups , or
  • G05B 15/02 - Systems controlled by a computer electric
  • G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 69/06 - Flat membranes
  • B01D 71/12 - Cellulose derivatives
  • B29K 1/00 - Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
  • B29K 105/04 - Condition, form or state of moulded material cellular or porous
  • B29L 31/00 - Other particular articles

83.

Electrospun fibers for protein stabilization and storage

      
Application Number 14140127
Grant Number 10202636
Status In Force
Filing Date 2013-12-24
First Publication Date 2015-06-25
Grant Date 2019-02-12
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Li, Bing
  • Moore, David Roger
  • Alberts, William Christopher
  • Nelson, John Richard

Abstract

An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

84.

Substrates and associated methods for elution of nucleic acids

      
Application Number 14068532
Grant Number 09719082
Status In Force
Filing Date 2013-10-31
First Publication Date 2015-04-30
Grant Date 2017-08-01
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Li, Bing
  • Grossmann, Gregory Andrew
  • Moore, David Roger

Abstract

A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate comprises a surface modified with a plurality of hydrophilic groups; and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

85.

Substrates and associated methods for elution of nucleic acids

      
Application Number 14068633
Grant Number 09534214
Status In Force
Filing Date 2013-10-31
First Publication Date 2015-04-30
Grant Date 2017-01-03
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Li, Bing
  • Grossmann, Gregory Andrew
  • Kvam, Erik Leeming
  • Bales, Brian Christopher
  • Davis, Jason Louis

Abstract

A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate is coated with saccharides, such as monosaccharides, oligosaccharides, polysaccharides or combinations thereof, and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
  • B01J 20/26 - Synthetic macromolecular compounds

86.

Isothermal amplification using oligocation-conjugated primer sequences

      
Application Number 14027947
Grant Number 09410172
Status In Force
Filing Date 2013-09-16
First Publication Date 2015-03-19
Grant Date 2016-08-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard

Abstract

Provided herein are methods and kits for isothermal nucleic acid amplifications that use an oligocation-oligonucleotide conjugate primer for amplifying a target nucleic acid to generate amplicons. Isothermal DNA amplification methods that employ a strand displacing DNA polymerase and polyamine-oligonucleotide conjugate primer are also provided.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

87.

Detection of nucleic acid amplification in a porous substrate

      
Application Number 13970315
Grant Number 09714447
Status In Force
Filing Date 2013-08-19
First Publication Date 2015-02-19
Grant Date 2017-07-25
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Finehout, Erin Jean
  • Puleo, Christopher Michael
  • Lenigk, Ralf
  • Nichols, Jason M.
  • Nelson, John

Abstract

The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

88.

Ligase-assisted nucleic acid circularization and amplification

      
Application Number 13952040
Grant Number 09217167
Status In Force
Filing Date 2013-07-26
First Publication Date 2015-01-29
Grant Date 2015-12-22
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard
  • Kvam, Erik Leeming

Abstract

Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any intervening purification steps. The single-stranded DNA circle is generated via a template-independent single-stranded DNA ligation. Whole-genome amplification of circulating nucleic acids extracted from blood is provided. Kits for performing the disclosed methods are also provided.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

89.

Methods for electroelution of biomolecules

      
Application Number 13951881
Grant Number 09999856
Status In Force
Filing Date 2013-07-26
First Publication Date 2015-01-29
Grant Date 2018-06-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Nelson, John Richard
  • Spooner, Patrick Mccoy
  • Lenigk, Ralf
  • Wood, Nichole Lea
  • Zhu, Li
  • Galligan, Craig Patrick

Abstract

A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.

IPC Classes  ?

  • B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

90.

Devices and systems for elution of biomolecules

      
Application Number 13951929
Grant Number 09333463
Status In Force
Filing Date 2013-07-26
First Publication Date 2015-01-29
Grant Date 2016-05-10
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Nelson, John Richard
  • Spooner, Patrick Mccoy
  • Lenigk, Ralf
  • Wood, Nichole Lea
  • Zhu, Li
  • Galligan, Craig Patrick

Abstract

A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.

IPC Classes  ?

  • G01N 27/447 - Systems using electrophoresis
  • B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis

91.

Method and device for collection and amplification of circulating nucleic acids

      
Application Number 13952173
Grant Number 09644232
Status In Force
Filing Date 2013-07-26
First Publication Date 2015-01-29
Grant Date 2017-05-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Nelson, John Richard
  • Grossmann, Gregory Andrew
  • Heller, Ryan Charles
  • Finehout, Erin Jean
  • Puleo, Christopher Michael
  • Waters, William Patrick

Abstract

Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

92.

Methods for developing binding-elements and uses thereof

      
Application Number 13929976
Grant Number 09765375
Status In Force
Filing Date 2013-06-28
First Publication Date 2015-01-01
Grant Date 2017-09-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Murray, Anthony John
  • Nelson, John Richard

Abstract

Methods for developing a binding-element are provided. A mixture comprising a target molecule, a plurality of oligonucleotides and a ligase is provided, followed by binding the oligonucleotides to the target molecule to form an oligonucleotides-target molecule complex. The oligonucleotides bound to the target molecule are ligated to form the binding-element. The binding-elements are separated from the mixture.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof

93.

Biological sample collection device

      
Application Number 14354933
Grant Number 09757096
Status In Force
Filing Date 2012-10-31
First Publication Date 2014-10-09
Grant Date 2017-09-12
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Pierce, Alan Stuart
  • Stubbs, Simon Laurence John
  • Treharne, David Gwyn
  • Potts, Cheryl Louise

Abstract

Biological samples, such as saliva, are commonly collected on a swab and subsequently transferred to an absorbent storage medium. Embodiments of the present invention provide a biological sample collection device 600 comprising a collection portion 620 and a body portion 610, the body portion including a holding portion 652 for holding a biological sample storage medium (618 FIG. 1), and a sample collection/transfer means. The collection portion 620 can be arranged in a first position shown in FIG. 4, separated from the body portion for collecting a sample. The device employs depressible latches (630, 640 FIG. 6) to control the movements of the collection portion.

IPC Classes  ?

  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

94.

Method and system for selective isolation of target biological molecules in a general purpose system

      
Application Number 14285099
Grant Number 09506847
Status In Force
Filing Date 2014-05-22
First Publication Date 2014-09-11
Grant Date 2016-11-29
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Duthie, Robert Scott
  • Tian, Wei-Cheng
  • Khurana, Tarun

Abstract

Embodiments of the present techniques provide systems and methods for isolating particular classes of biological molecules, for example, proteins or nucleic acids, from mixtures of biological components. The methods use solutions that react with the biological molecules to enhance their adsorption by substrates, allowing contaminants to be washed away from the targeted molecules. Embodiments include automated systems that can be used to implement the technique with no or minimal intervention. Other embodiments include separation column technologies that may be used in the techniques.

IPC Classes  ?

  • G01N 1/34 - Purifying; Cleaning
  • C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 27/447 - Systems using electrophoresis
  • G01N 30/24 - Automatic injection systems

95.

Methods and systems for processing samples on porous substrates

      
Application Number 14202222
Grant Number 09254484
Status In Force
Filing Date 2014-03-10
First Publication Date 2014-09-04
Grant Date 2016-02-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Shoemaker, Philip Alexander
  • Griffin, Weston Blaine
  • Finehout, Erin Jean
  • Wang, Xuefeng
  • Shaikh, Kashan Ali
  • Goddard, Greg Darryl

Abstract

Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

IPC Classes  ?

  • G01N 1/40 - Concentrating samples
  • G01N 1/28 - Preparing specimens for investigation
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 1/34 - Purifying; Cleaning
  • G01N 30/72 - Mass spectrometers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

96.

Substrates and methods for collection, stabilization and elution of biomolecules

      
Application Number 14261900
Grant Number 09480966
Status In Force
Filing Date 2014-04-25
First Publication Date 2014-08-21
Grant Date 2016-11-01
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kovacs, Ernest William
  • Kvam, Erik Leeming
  • Li, Bing
  • Mondello, Frank John

Abstract

A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.

IPC Classes  ?

  • B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
  • B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
  • C07K 1/14 - Extraction; Separation; Purification
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/32 - Impregnating or coating

97.

Solid medium for the storage of biological material

      
Application Number 13798483
Grant Number 09365890
Status In Force
Filing Date 2013-03-13
First Publication Date 2014-07-31
Grant Date 2016-06-14
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • James, Martin D.
  • Horton, Jeffrey K.
  • Tatnell, Peter J.

Abstract

This invention relates to flat solid media for the storage of samples of biological materials and methods of analyzing biomolecules contained within the samples following storage. In particular, the invention relates to the storage and further analysis of biomolecules present in the biological materials, such as proteins, enzymes and nucleic acids. The invention finds particular utility in the dry, room temperature storage of biological materials.

IPC Classes  ?

  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

98.

Device and method for drying biological sample on substrate

      
Application Number 13690801
Grant Number 09063041
Status In Force
Filing Date 2012-11-30
First Publication Date 2014-06-05
Grant Date 2015-06-23
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Nelson, John Richard
  • Spooner, Patrick Mccoy
  • Lenigk, Ralf

Abstract

A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • G01N 1/30 - Staining; Impregnating
  • G01N 1/40 - Concentrating samples

99.

Solid matrix for one step nucleic acid amplification

      
Application Number 13799174
Grant Number 09260711
Status In Force
Filing Date 2013-03-13
First Publication Date 2014-06-05
Grant Date 2016-02-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lamerton, Kathryn L.
  • Potts, Cheryl L.
  • Stubbs, Simon L.
  • Kenrick, Michael K.

Abstract

The present invention to relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. The PCR reagents are bound to a solid matrix for easy processing and amplification of DNA samples.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

100.

Biological sample collection device

      
Application Number 14122291
Grant Number 08998824
Status In Force
Filing Date 2012-05-24
First Publication Date 2014-04-10
Grant Date 2015-04-07
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Pierce, Alan Stuart
  • Potts, Cheryl Louise
  • Stubbs, Simon Laurence John
  • Treharne, David Gwyn

Abstract

Biological samples, such as saliva, are commonly collected on a swab and subsequently transferred to an absorbent storage medium. Embodiments of the present invention provide a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter. This provides an improved means of collecting a biological sample.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
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