Global Life Sciences Solutions Operations UK Limited

United Kingdom

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IPC Class
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 40
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 33
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA 29
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides 23
C12M 1/00 - Apparatus for enzymology or microbiology 19
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01 - Chemical and biological materials for industrial, scientific and agricultural use 39
09 - Scientific and electric apparatus and instruments 30
10 - Medical apparatus and instruments 12
05 - Pharmaceutical, veterinary and sanitary products 10
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1.

POROUS POLYMERIC MEMBRANE WITH TEAR PREVENTION RING

      
Application Number 18396391
Status Pending
Filing Date 2023-12-26
First Publication Date 2024-04-18
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
Inventor
  • Albagli, Douglas
  • Hennessy, William A.

Abstract

Porous liquid-filtering membranes are provided having a boundary region substantially surrounding the pore region and having greater tear resistance than the pore region.

IPC Classes  ?

  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors

2.

APPARATUS, SYSTEM, AND METHOD FOR BIOPROCESSING UTILIZING A ROCKER BIOREACTOR

      
Application Number EP2023077425
Publication Number 2024/074546
Status In Force
Filing Date 2023-10-04
Publication Date 2024-04-11
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED (United Kingdom)
Inventor
  • Parvizi, Mojtaba
  • Mizzoni, Craig
  • Ryan, Mackenzie

Abstract

In an embodiment, a bioprocessing method includes securing a vessel containing a fluid to a platform capable of pivoting about a first axis, heating the fluid in the vessel while the platform is in a static, substantially upright position to facilitate a first bioprocessing procedure within the vessel. The method further includes pivoting the platform and vessel about the first axis to create a rocking motion to facilitate a second bioprocessing procedure within the vessel.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • B01F 31/23 - Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means

3.

SPARGER ASSEMBLIES FOR A BIOPROCESSING SYSTEM

      
Application Number EP2023075132
Publication Number 2024/061703
Status In Force
Filing Date 2023-09-13
Publication Date 2024-03-28
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED (United Kingdom)
Inventor Diana, Rafael

Abstract

A sparger assembly (100) for a bioprocessing system (10) includes a base (126) and a plurality of spargers (130) connected to the base, each sparger including a plurality of pores, the plurality of spargers each have a generally cylindrical shape. Each of the plurality of spargers includes a sidewall and a top, which define the cylindrical shape, the sidewall and the top each include a plurality of pores. The pores of the sidewall can be arranged around a circumference of the sidewall at an array of heights. Ridges may also be located on the sidewall above a respective array of pores.

IPC Classes  ?

  • B01F 23/231 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
  • B01F 23/233 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
  • B01F 33/453 - Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
  • B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers
  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • B01F 101/44 - Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

4.

APPARATUS, SYSTEM, AND METHOD FOR REDUCING A MINIMUM WORKING VOLUME OF A BIOREACTOR

      
Application Number EP2023070705
Publication Number 2024/028181
Status In Force
Filing Date 2023-07-26
Publication Date 2024-02-08
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED (United Kingdom)
Inventor
  • Rao, Nagaraj
  • Smeltzer, Thomas
  • Mathapati, Milind
  • Tracy Beem, Heather
  • Murugesan, Kandakumar
  • Balakrishnan, Saravanan
  • Chattopadhyay, Subhanjan

Abstract

An apparatus (30) for reducing a minimum working volume of a stirred tank (12) includes a body (32) having upper (46) and lower (48) surfaces, and an exterior profile shaped to closely fit within an interior of the stirred tank. The body including an interior portion (34) extending through the body (32) from the upper surface to the lower surface, the interior portion configured to receive and partially surround an impeller (200) within the stirred tank, while allowing rotation of the impeller to agitate a fluid in the vessel when in use. The body further including an opening in a side surface of the body, the opening extending into the interior portion and configured to facilitate removal of fluid (60) from the vessel when the stirred tank is in use, and to be removed from the stirred tank via a drain.

IPC Classes  ?

  • B01F 33/453 - Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
  • B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers
  • C12M 1/00 - Apparatus for enzymology or microbiology

5.

APPARATUS AND METHOD FOR AGITATING A FLUID

      
Application Number EP2023069816
Publication Number 2024/022874
Status In Force
Filing Date 2023-07-17
Publication Date 2024-02-01
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED (United Kingdom)
Inventor
  • Murugesan, Kandakumar
  • Kandoth, Bineesh
  • Rao, Nagaraj

Abstract

A vessel (24) includes an interior volume (25) containing a liquid, a spiral shaft (28) located within the interior volume, and a rotatable impeller (30). The impeller has an aperture (38) that receives the spiral shaft and allows the impeller to travel bidirectionally along the spiral shaft. When the impeller travels along the spiral shaft, the impeller rotates axially about the spiral shaft to agitate a liquid in the interior volume.

IPC Classes  ?

  • B01F 27/07 - Stirrers characterised by their mounting on the shaft
  • B01F 31/40 - Mixers with shaking, oscillating, or vibrating mechanisms with an axially oscillating rotary stirrer
  • B01F 33/453 - Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
  • B01F 35/513 - Flexible receptacles, e.g. bags supported by rigid containers
  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
  • B01F 101/44 - Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

6.

Tissue processing bag

      
Application Number 29778672
Grant Number D0988538
Status In Force
Filing Date 2021-04-14
First Publication Date 2023-06-06
Grant Date 2023-06-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Divekar, Devina
  • Rajan, Thiyaga

7.

Tissue processing bag clamp

      
Application Number 29778720
Grant Number D0987851
Status In Force
Filing Date 2021-04-14
First Publication Date 2023-05-30
Grant Date 2023-05-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Divekar, Devina
  • Marteleur, Klas
  • Lundberg, Joergen
  • Hari, Priya

8.

HCPQUANT

      
Application Number 1713619
Status Registered
Filing Date 2023-01-04
Registration Date 2023-01-04
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Enzyme-linked immunosorbent assay kit, used to quantify and characterize proteins in process-derived samples harvested from host cells; chemical preparations for scientific purposes, other than for medical or veterinary use; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; diagnostic reagents and preparations, except for medical or veterinary use.

9.

HCPQUANT

      
Serial Number 79362916
Status Registered
Filing Date 2023-01-04
Registration Date 2024-03-26
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Enzyme-linked immunosorbent assay kit comprised of assays for research purposes used to quantify and characterize proteins in process-derived samples harvested from host cells; chemical preparations for scientific purposes, other than for medical or veterinary use; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; diagnostic reagents and preparations, except for medical or veterinary use

10.

HCPQUANT

      
Application Number 018816482
Status Registered
Filing Date 2022-12-28
Registration Date 2023-05-12
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Enzyme-linked immunosorbent assay kit, used to quantify and characterize proteins in process-derived samples harvested from host cells; chemical preparations for scientific purposes, other than for medical or veterinary use; chemical preparations for analyses in laboratories, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical reagents, other than for medical or veterinary purposes; diagnostic reagents and preparations, except for medical or veterinary use.

11.

MAGRACK

      
Application Number 1702397
Status Registered
Filing Date 2022-11-23
Registration Date 2022-11-23
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory scientific apparatus, including holder and rack systems.

12.

WHATMAN

      
Application Number 1702105
Status Registered
Filing Date 2022-06-06
Registration Date 2022-06-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments
  • 16 - Paper, cardboard and goods made from these materials

Goods & Services

Chemical products, preparations and substances for use in science and industry; papers (chemically treated or containing chemicals); test papers; sensitised papers; indicator papers; modified and chemically treated glass in fibre form; silica (chemically treated); cellulose powders; chemically treated cellulose; ion-exchange materials; buffer solutions; test papers, impregnated with chemical or compounds; all for filtration, separation, analysis and testing in laboratories, industry, environmental and medical research and research. Sterilising preparations; filtering preparations, materials and media for pharmaceutical, medical and sanitary purposes; air purifying preparations; filter capsules for pharmaceutical purposes; diagnostic preparations for medical purposes, diagnostic test kits for medical purposes; filters for the treatment, separation, or decontamination of gas, air or liquids for pharmaceutical purposes; chemical reagents for medical purposes; bacterial and biological preparations and cultures for medical use; blood plasma separating filters; cellulose for pharmaceutical purposes; chemico-pharmaceutical preparations. Scientific and laboratory apparatus and instruments; measuring, weighing, monitoring and checking apparatus and instruments; apparatus for chemical separation; filters, filter units and filter tubes and cartridges; apparatus for chemical separation; chromatography columns and equipment; separating funnels; soxhlet thimbles made from organic or in organic fibres; extraction symbols for use in chemical analysis being laboratory apparatus and instruments; diagnostic testing apparatus (not for medical purposes); stills for laboratory experiments; membranes for gas separators; cellulose nitrate membranes; media and membranes for storage of samples; pipette controllers; hot plate stirrers; chromatography papers; all for use for laboratories, industry, research, education and environmental testing. Medical, dental and veterinary apparatus and instruments; filtering materials for medical use; filter membranes, pharmaceutical grade aqueous filters, sterile vent filters, filters for use in blood and plasma separation, inline gas or air filters used in respiratory filtration, filter capsules, molecular sieves, IV filters, encapsulated filter devices, pre-filters, multi layer filters, disposable filtration capsules, microporous membranes, hydrophilic membranes, hydrophobic membranes, hydrophobic filters, glass microfibre filters, filter cartridges, pleated filter cartridges, radiation sterilizable filtering materials, microaggregate transfusion filters, filter housings; tubing sets for insufflation; ribbed or non-ribbed tubing; drain assemblies (tubing); connectors for filters and tubing, luer locks, barbs, sealing rings, clamps; all the aforesaid for medical, dental, veterinary or scientific purposes; filter capsules for medical purposes; filters for the treatment, separation, or decontamination of gas, air or liquids for medical purposes; blood plasma separating filters. Paper and paper articles; filter papers, chemically treated papers for filtering purposes, polyethylene and polythene backed papers, lens cleaning papers, drawing papers, writing papers, printmaking papers, test papers, not impregnated with chemical or compounds, blotting papers, carbon paper, electrocardiograph paper, paper sheets, paper rolls; bags [envelopes, pouches] of paper or plastics, for packaging; packaging containers of paper or cardboard; blotters.

13.

CELL-FREE PROTEIN EXPRESSION USING ROLLING CIRCLE AMPLIFICATION PRODUCT

      
Application Number 17813568
Status Pending
Filing Date 2022-07-19
First Publication Date 2022-12-08
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.

IPC Classes  ?

  • C12P 21/00 - Preparation of peptides or proteins
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression

14.

IMPROVEMENTS IN AND RELATING TO THE MONITORING OF CELL EXPANSION

      
Application Number 17617274
Status Pending
Filing Date 2020-06-09
First Publication Date 2022-09-22
Owner
  • Global Life Sciences Solutions Operations UK LTD (United Kingdom)
  • The Regents of the University of California (USA)
Inventor
  • Goodwin, Paul C.
  • Bowles, Paul Anthony
  • Iyer, Rohin
  • Gratch, Yarden
  • Mccartney, Mitch M.
  • Yamaguchi, Mei S.
  • Davis, Cristina E.

Abstract

Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.

IPC Classes  ?

  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12N 5/075 - Oocytes; Oogonia
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
  • G01N 30/02 - Column chromatography
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 33/483 - Physical analysis of biological material

15.

MEMBRANE TRANSFER CASSETTE

      
Application Number EP2022056987
Publication Number 2022/195009
Status In Force
Filing Date 2022-03-17
Publication Date 2022-09-22
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Hamilton, Andrew
  • Hortua Diaz, Alejandra
  • Hernandez Vera, Rodrigo
  • Larsson, Kjell
  • Nilsson, Erik

Abstract

Provided is a membrane transfer cassette for electroblotting, the cassette comprising a first support panel and a second support panel, at least a region of one or each of the first and second support panels having an interlocking pattern of polygonal apertures. The membrane transfer cassette is particularly useful when electroblotting with large format gels as the design of the cassette increases the exposed surface area between the gel and the membrane while also enhancing the strength of the cassette to support large gels but is also advantageous for any size of gel.

IPC Classes  ?

  • B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
  • G01N 27/447 - Systems using electrophoresis

16.

VIRAL FILTER AND METHOD OF VIRAL FILTRATION

      
Application Number EP2022056989
Publication Number 2022/195010
Status In Force
Filing Date 2022-03-17
Publication Date 2022-09-22
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nunes, Claudia, Trindade
  • Lorenzetti, Martina

Abstract

The present invention provides for simple and rapid filtering of biological samples, whereby a sample can be analyzed in the same device or a different device. In one preferred example, a membrane filter (12) that is particularly useful for the filtration of samples comprising viruses along with other biological materials that need be separated from the viruses is used. A lateral flow device (10) incorporating a filter membrane/membrane filter (12) is also disclosed.

IPC Classes  ?

  • B01D 63/08 - Flat membrane modules
  • B01D 69/10 - Supported membranes; Membrane supports
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody

17.

METHODS AND APPARATUS FOR SCALING IN BIOPROCESS SYSTEMS

      
Application Number EP2021076862
Publication Number 2022/122211
Status In Force
Filing Date 2021-09-29
Publication Date 2022-06-16
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Castan, Andreas
  • Ohrvik, Helena
  • Konduru, Nagaraju
  • Handa, Ashish
  • Boddapati, Neelima
  • Chauhan, Alok, Singh

Abstract

Methods and apparatus for scaling in bioprocess systems are disclosed. An example apparatus for bioprocess scaling includes at least one memory to store instructions, and processor circuitry to execute the instructions to identify at least one operating parameter of a target bioreactor, determine an upper boundary and/or a lower boundary defining a design space for at least one bioreactor process parameter to match at least one target parameter range based on the at least one operating parameter, simulate changes in the at least one target parameter range based on an adjustment to the upper boundary and/or the lower boundary in the design space, and configure the target bioreactor using output obtained from the adjustment to the upper boundary and/or the lower boundary to identify a match between the at least one target parameter range and a user-based input of a target bioprocess parameter value.

IPC Classes  ?

  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

18.

POROUS POLYMERIC MEMBRANE WITH TEAR PREVENTION RING

      
Application Number EP2021082844
Publication Number 2022/122389
Status In Force
Filing Date 2021-11-24
Publication Date 2022-06-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED (United Kingdom)
Inventor
  • Albagli, Douglas
  • Hennessy, William A

Abstract

Porous liquid-filtering membranes (102) are provided having a boundary region (303) substantially surrounding a pore region (302) and having greater tear resistance than the pore region (302). In various aspects, a liquid-filtering tear-resistant porous polymeric membrane (102) comprises a pore region (302) comprising a plurality of pores having a minimum dimension of less than (100) microns and a ring-shaped tear- resistant boundary region (303).

IPC Classes  ?

  • B01D 61/14 - Ultrafiltration; Microfiltration
  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors

19.

Porous polymeric membrane with tear prevention ring

      
Application Number 17115054
Grant Number 11896934
Status In Force
Filing Date 2020-12-08
First Publication Date 2022-06-09
Grant Date 2024-02-13
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
Inventor
  • Albagli, Douglas
  • Hennessy, William A.

Abstract

Porous liquid-filtering membranes are provided having a boundary region substantially surrounding the pore region and having greater tear resistance than the pore region.

IPC Classes  ?

  • B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors

20.

WHATMAN

      
Application Number 222796900
Status Pending
Filing Date 2022-06-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments
  • 16 - Paper, cardboard and goods made from these materials

Goods & Services

(1) Chemical products, preparations and substances for use in science and industry; papers (chemically treated or containing chemicals); test papers; sensitised papers; indicator papers; modified and chemically treated glass in fibre form; silica (chemically treated); cellulose powders; chemically treated cellulose; ion-exchange materials; buffer solutions; test papers, impregnated with chemical or compounds; all for filtration, separation, analysis and testing in laboratories, industry, environmental and medical research and research. (2) Sterilising preparations; filtering preparations, materials and media for pharmaceutical, medical and sanitary purposes; air purifying preparations; filter capsules for pharmaceutical purposes; diagnostic preparations for medical purposes, diagnostic test kits for medical purposes; filters for the treatment, separation, or decontamination of gas, air or liquids for pharmaceutical purposes; chemical reagents for medical purposes; bacterial and biological preparations and cultures for medical use; blood plasma separating filters; cellulose for pharmaceutical purposes; chemico-pharmaceutical preparations. (3) Scientific and laboratory apparatus and instruments; measuring, weighing, monitoring and checking apparatus and instruments; apparatus for chemical separation; filters, filter units and filter tubes and cartridges; apparatus for chemical separation; chromatography columns and equipment; separating funnels; soxhlet thimbles made from organic or in organic fibres; extraction symbols for use in chemical analysis being laboratory apparatus and instruments; diagnostic testing apparatus (not for medical purposes); stills for laboratory experiments; membranes for gas separators; cellulose nitrate membranes; media and membranes for storage of samples; pipette controllers; hot plate stirrers; chromatography papers; all for use for laboratories, industry, research, education and environmental testing. (4) Medical, dental and veterinary apparatus and instruments; filtering materials for medical use; filter membranes, pharmaceutical grade aqueous filters, sterile vent filters, filters for use in blood and plasma separation, inline gas or air filters used in respiratory filtration, filter capsules, molecular sieves, IV filters, encapsulated filter devices, pre-filters, multi layer filters, disposable filtration capsules, microporous membranes, hydrophilic membranes, hydrophobic membranes, hydrophobic filters, glass microfibre filters, filter cartridges, pleated filter cartridges, radiation sterilizable filtering materials, microaggregate transfusion filters, filter housings; tubing sets for insufflation; ribbed or non-ribbed tubing; drain assemblies (tubing); connectors for filters and tubing, luer locks, barbs, sealing rings, clamps; all the aforesaid for medical, dental, veterinary or scientific purposes; filter capsules for medical purposes; filters for the treatment, separation, or decontamination of gas, air or liquids for medical purposes; blood plasma separating filters. (5) Paper and paper articles; filter papers, chemically treated papers for filtering purposes, polyethylene and polythene backed papers, lens cleaning papers, drawing papers, writing papers, printmaking papers, test papers, not impregnated with chemical or compounds, blotting papers, carbon paper, electrocardiograph paper, paper sheets, paper rolls; bags [envelopes, pouches] of paper or plastics, for packaging; packaging containers of paper or cardboard; blotters.

21.

WHATMAN

      
Serial Number 79357853
Status Pending
Filing Date 2022-06-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments
  • 16 - Paper, cardboard and goods made from these materials

Goods & Services

Chemicals, chemical preparations and chemical substances for use in science and industry, other than for medical or veterinary purposes; test paper, chemical test papers; sensitised papers; indicator papers; modified and chemically treated glass in fibre form in the nature of glass staining chemicals; chemical preparation in the nature of silica based density centrifugation media to be used in biochemical and clinical research, silica gel silica (chemically treated); cellulose powders being cellulose; chemically treated cellulose; buffer solutions for use in analytical chemistry; chemical test papers, namely, test papers, impregnated with chemical or compounds; all for filtration, separation, analysis and testing in laboratories, industry, environmental and medical research and research Sterilising preparations; filtering aids, materials and media for pharmaceutical, medical and sanitary purposes; air purifying preparations; filter capsules for pharmaceutical purposes; diagnostic preparations for medical purposes, diagnostic test kits for medical purposes comprised of medical diagnostic reagents and assays for testing body fluids; filters for the treatment, separation, or decontamination of gas, air or liquids for pharmaceutical purposes; chemical reagents for medical purposes; bacterial preparations for medical use, and cell therapy preparations for the treatment of cancer and biological tissue cultures for medical use; blood plasma separating filters being blood plasma; cellulose ethers for pharmaceutical purposes; chemico-pharmaceutical preparations for medical use Scientific and laboratory apparatus and instruments, namely, apparatus for chemical separation, all for use for laboratories, industry, research, education and environmental testing; laboratory filters, filter units and filter tubes and cartridges, all for use for laboratories, industry, research, education and environmental testing; chromatography columns for laboratory use; laboratory equipment, namely, separating funnels, all for use for laboratories, industry, research, education and environmental testing; extraction thimbles made from organic or in organic fibres, all for use for laboratories, industry, research, education and environmental testing; extraction symbols for use in chemical analysis being laboratory apparatus and instruments, all for use for laboratories, industry, research, education and environmental testing; wipes and swabs for use in diagnostic testing, not for medical purposes; diagnostic testing apparatus (not for medical purposes), all for use for laboratories, industry, research, education and environmental testing; stills for laboratory experiments, all for use for laboratories, industry, research, education and environmental testing; scientific apparatus in the nature of membranes for gas separators for use in science and research industry; cellulose nitrate membranes, all for use for laboratories, industry, research, education and environmental testing; media and membranes for storage of samples, all for use for laboratories, industry, research, education and testing; pipette controllers being pipette racks for laboratory use; hot plate stirrers, all for use for laboratories, industry, research, education and environmental testing; chromatography papers, all for use for laboratories, industry, research, education and environmental testing Medical, dental and veterinary apparatus and instruments, namely, filtration devices, all for use for laboratories, industry, research, education and testing; filtering materials for medical use, namely air filters for medical ventilators, blood filters, filters for anesthesia for use in laboratories, industry, research, education and testing; filters for medical purposes, namely, filter membranes, pharmaceutical grade aqueous filters, sterile vent filters, filters for use in blood and plasma separation, inline gas or air filters used in respiratory filtration, filter capsules, molecular sieves, IV filters, encapsulated filter devices, pre-filters, multi layer filters, disposable filtration capsules, microporous membranes, hydrophilic membranes, hydrophobic membranes, hydrophobic filters, glass microfibre filters, filter cartridges, pleated filter cartridges, radiation sterilizable filtering materials, microaggregate transfusion filters, filter housings; all for use for laboratories, industry, research, education and testing; blood tubing sets for insufflation; ribbed or non-ribbed tubing being medical tubing for drainage or transfusion; drainage tubes for medical purposes; all for use for laboratories, industry, research, education and testing; connectors for filters and tubing, luer locks, barbs, sealing rings, clamps in the nature of oxygen nasal cannula clamps for securing medical tubing; filter capsules for medical purposes; filters for the treatment, separation, or decontamination of gas, air or liquids for medical purposes; medical device, namely, blood plasma separating filters, all for use for laboratories, industry, research, education and testing Paper; filter papers, filter papers in the nature of chemically treated papers for filtering purposes, paper in the nature of polyethylene and polythene backed papers, paper in the nature of lens cleaning papers, drawing papers, writing papers, printmaking papers, paper in the nature of test papers, not impregnated with chemical or compounds, blotting papers, carbon paper, electrocardiograph paper

22.

SYSTEM AND METHOD FOR ASEPTIC SAMPLING AND FLUID ADDITION

      
Application Number EP2021079802
Publication Number 2022/106165
Status In Force
Filing Date 2021-10-27
Publication Date 2022-05-27
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Timmins, Mark, R
  • Sherman, Matthew
  • Ali, Yasser
  • Picardo, Marc
  • Benoit, Keith

Abstract

A sampling system includes a graduated sampling chamber configured for fluid connection to a sample source, a pump device configured for fluid connection with the sampling chamber, and a sterile air filter intermediate the pump device and the sampling chamber, wherein the pump device is selectively actuatable to draw a volume of fluid from the sample source into the sampling chamber.

IPC Classes  ?

  • C12M 1/26 - Inoculator or sampler
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers

23.

MAGRACK

      
Serial Number 97428782
Status Registered
Filing Date 2022-05-25
Registration Date 2023-10-03
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory scientific apparatus, namely, tube holders and racks

24.

STERILE FOAM BREAKING SYSTEM AND ASSOCIATED METHOD THEREOF

      
Application Number EP2021079286
Publication Number 2022/096284
Status In Force
Filing Date 2021-10-21
Publication Date 2022-05-12
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Balakrishnan, Saravanan
  • Murugesan, Kandakumar
  • Rao, Nagaraj, Raghavendra
  • Hegde, Shashidhar

Abstract

A sterile foam breaking system (14, 42, 52) includes a foam collector (20) having an opening (26), configured to be disposed in a source (12) which generates foam. The sterile foam breaking system (14, 42, 52) further includes a non-contact type suction unit (23) coupled to the foam collector (20). The non-contact type suction unit (23) is configured to transfer the foam via the opening (26) of the foam collector (20) and break a portion of the foam to generate a first quantity of liquid droplets. The sterile foam breaking system (14, 42, 52) additionally includes a foam breaking unit (28, 44, 54) coupled to the non-contact type suction unit (23). The foam breaking unit (28, 44, 54) is configured to receive remaining portion of the foam and the first quantity of liquid droplets and break the remaining portion of the foam to generate a second quantity of liquid droplets.

IPC Classes  ?

  • B01D 19/02 - Foam dispersion or prevention
  • C12M 1/00 - Apparatus for enzymology or microbiology

25.

TISSUE DISAGGREGATION

      
Application Number EP2021079070
Publication Number 2022/090021
Status In Force
Filing Date 2021-10-20
Publication Date 2022-05-05
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Marteleur, Klas
  • Divekar, Devina

Abstract

The present invention relates to a sample processing bag (10) for use in a tissue disaggregation apparatus (200) for disaggregation of tissue therein. A clamp assembly 60 comprising a base support (70) and a clamp mechanism (72) is configured to retain the sample processing bag (10) adjacent to the base support (70) during a tissue disaggregation operation such that action of the tissue disaggregation apparatus 200 acts on the sample processing bag (10) to disaggregate any tissue therein.

IPC Classes  ?

26.

BIOPROCESSING SYSTEM AND APPARATUS FOR REDUCING CELL SHEAR IN A BIOPROCESSING SYSTEM

      
Application Number EP2021076469
Publication Number 2022/073783
Status In Force
Filing Date 2021-09-27
Publication Date 2022-04-14
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Balakrishnan, Saravanan
  • Murugesan, Kandakumar
  • Rao, Nagaraj, Raghavendra
  • Ouellette, Matthew, D

Abstract

An apparatus (100) for managing gas bubbles (50) in a bioprocessing system (10) includes a body portion (110) having a underside surface (112), and an opening (114) in the body portion (110). The body portion (110) is configured for placement within a bioreactor vessel (12) such that the underside surface (112) of the body portion (110) is disposed in a liquid within the bioreactor vessel (12). The underside surface (112) of the body portion (110) is configured to divert rising gas bubbles (50) in the liquid towards the opening (114).

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology

27.

TANGENTIAL FLOW CASSETTE-HF EMULATION

      
Application Number EP2021077435
Publication Number 2022/073999
Status In Force
Filing Date 2021-10-05
Publication Date 2022-04-14
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Hennessy, William A
  • Albagli, Douglas
  • Stankowski, Ralph

Abstract

A biocompatible polymeric membrane includes pores (106) defined between two material layers, where the first membrane material layer (101) includes strips, and the second membrane material (104) binds to each of the plurality of first membrane material layer strips (101) includes a plurality of windows (105) exposing each of the first membrane material strips (101). The biocompatible polymeric filtration membrane comprises pores (106) defined by uniform passages defined by the first membrane material layer strips (101) and the second membrane material layer (104) within each window (105).

IPC Classes  ?

  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
  • B01D 69/12 - Composite membranes; Ultra-thin membranes
  • B01D 71/64 - Polyimides; Polyamide-imides; Polyester-imides; Polyamide acids or similar polyimide precursors

28.

METHOD AND APPARATUS FOR BIOPROCESS MONITORING

      
Application Number EP2021076015
Publication Number 2022/069307
Status In Force
Filing Date 2021-09-22
Publication Date 2022-04-07
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Viswanathan, Aravind, Kumar
  • Seshadri, Jaisimha
  • Sandusky, Christopher
  • S, Suthish, Kumar
  • Ca, Shanmuganathan
  • Arumugam, Sasikumar

Abstract

Methods and apparatus for bioprocess monitoring are disclosed. An example apparatus includes a controller to monitor a first bioprocess instrument, a data logger to collect data for the first bioprocess instrument, the collected data including data collected while the first bioprocess instrument is transferred from a first location to a second location, a configurator to configure the first bioprocess instrument to operate in a first mode at the first location and in a second mode at the second location, the first or second mode determined based on a type of processing at the first or second location, and a user interface to display the collected data to a user, the collected data including real-time bioprocess monitoring data, the controller to adjust a setting of the first bioprocess instrument based on the monitoring data, the monitoring data used to maintain controlled environmental conditions within a vessel of the instrument.

IPC Classes  ?

  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • G05B 15/00 - Systems controlled by a computer
  • G06N 3/00 - Computing arrangements based on biological models
  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

29.

COLLAPSIBLE AGITATOR ASSEMBLY FOR A BIOPROCESSING SYSTEM

      
Application Number EP2021072345
Publication Number 2022/048870
Status In Force
Filing Date 2021-08-11
Publication Date 2022-03-10
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Hashemi, Nasim

Abstract

A mixing system (10) includes a container (20) for containing a fluid, and an agitator assembly (100) disposable in the container (20) for mixing the fluid. The agitator (100) includes an extensible shaft (110) and at least one impeller (116, 118) connected to the extensible shaft (110).

IPC Classes  ?

  • B01F 7/00 - Mixers with rotary stirring devices in fixed receptacles; Kneaders
  • B01F 13/08 - Magnetic mixers
  • B01F 15/00 - Accessories for mixers
  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller

30.

NOVEL HIGH-DENSITY MICROCARRIER RETENTION DEVICE FOR PERFUSION CULTURE AND METHOD OF USE THEREOF

      
Application Number EP2021069061
Publication Number 2022/022983
Status In Force
Filing Date 2021-07-08
Publication Date 2022-02-03
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Yang, Jianjun
  • Yang, Hongyan

Abstract

The invention relates to the field of microcarrier perfusion culture of adherent cells. Specifically, the present invention relates to a high-density microcarrier retention device for perfusion culture of adherent cells, a microcarrier perfusion culture system for adherent cells containing the device, and methods of use thereof. The retention device of the present invention includes a sedimentation chamber, a pipeline connected to a bioreactor, a microcarrier retention filter membrane, a liquid backflushing device, an air backflushing device, a peristaltic pump and a pipeline connected to a receiver. The device has high efficiency in promoting the separation of microcarriers from cell culture medium and is helpful for perfusion culture of adherent cells and microcarriers. The retention device makes the culture volume in the bioreactor more flexible, can perform perfusion culture of 20%-100% of the maximum culture volume of the bioreactor, and the retention device can be linearly amplified according to the amplification of the bioreactor volume.

IPC Classes  ?

  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/00 - Apparatus for enzymology or microbiology

31.

BIOPROCESSING SYSTEM AND TUBING AND COMPONENT MANAGEMENT APPARATUS FOR A BIOPROCESSING SYSTEM

      
Application Number EP2021068988
Publication Number 2022/013057
Status In Force
Filing Date 2021-07-08
Publication Date 2022-01-20
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Stegner, Elizabeth
  • Murugesan, Kandakumar
  • Cherunni, Sairam
  • Dash, Manas
  • Bagiyanathan, Prasad
  • Selvaraj, Shivakumar
  • Kandoth, Bineesh
  • Maiya, Nityananda
  • Brocato, Nicholas
  • Dhanariya, Chandra, Prakash
  • Sundaramoorthy, Suresh

Abstract

A component management apparatus for a bioprocessing system includes a frame having a plurality of segments, including at least a first segment and a second segment pivotably connected to the first segment such that at least the second segment is movable between a closed position and an open position, and at least one mounting bracket connected to the frame for connection of a bioprocess component.

IPC Classes  ?

  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12M 1/00 - Apparatus for enzymology or microbiology

32.

BIOPROCESSING PERFUSION SYSTEM HAVING A PLURALITY OF FILTERS AND METHOD OF OPERATING THE SAME

      
Application Number EP2021069517
Publication Number 2022/013248
Status In Force
Filing Date 2021-07-13
Publication Date 2022-01-20
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Alagur, Sahebagouda
  • Mohan, Prashanth, Hosabettu
  • Paul, Praveen

Abstract

The bioprocessing perfusion system (10) includes a bioreactor (12) and a feed flow path (14). A first tangential flow filter (16) is coupled to the bioreactor (12) via the feed flow path (14) and a second tangential flow filter (18) is coupled to the bioreactor (12) via the feed flow path (14). The first tangential flow filter (16) is a microfiltration-type filter and the second tangential flow filter (18) is an ultrafiltration-type filter. The first tangential flow filter (16) and the second tangential flow filter (18) are further coupled to a receiving unit (58) via the permeate flow path (60). The first tangential flow filter (16) and the second tangential flow filter (18) are further coupled to the bioreactor (12) via the retentate flow path (46). A control unit (82) is communicatively coupled to the first feed control device (42), the second feed control device (44), the feed drive unit (40), the first permeate control device (64), the second permeate control device (66), the first retentate control device (48), and the second retentate control device (50).

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • B01D 61/14 - Ultrafiltration; Microfiltration

33.

PURADISC

      
Application Number 1630218
Status Registered
Filing Date 2021-10-29
Registration Date 2021-10-29
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory equipment, namely, syringe filters for use with disposable reusable dispenser syringes; laboratory filters.

34.

PURADISC

      
Application Number 215130200
Status Registered
Filing Date 2021-10-29
Registration Date 2024-02-26
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

(1) Laboratory equipment, namely, syringe filters for use with disposable, reusable dispenser syringes for scientific research in laboratories; laboratory filters, namely, syringe filters for scientific research in laboratories.

35.

MASHPREP

      
Application Number 1622518
Status Registered
Filing Date 2021-08-06
Registration Date 2021-08-06
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory equipment, namely, syringe filters for use with disposable dispenser syringes and reusable dispenser syringes.

36.

Biological Sample Collectors and Handling Thereof

      
Application Number 17160450
Status Pending
Filing Date 2021-01-28
First Publication Date 2021-09-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth
  • Norey, Christopher George
  • Pierce, Alan Stuart
  • John, Robert

Abstract

A biological sample collector 500 comprising a solid support 12 having plural discrete areas (22,24,26,28 FIG. 1) for accepting a biological sample, each area being chemically differentiated, for example by having a different chemical treatment sorbed onto the solid support. An envelope 530 encloses the solid support. A cover portion 520 can cover the biological sample after collection to prevent infection. UV light can be applied to the collected sample to reduce the risk of infection.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat

37.

Solid Support for Sample Collection

      
Application Number 17237518
Status Pending
Filing Date 2021-04-22
First Publication Date 2021-08-05
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Moran, Nina

Abstract

The present invention relates to means for collection of biological samples. Specifically, the present invention provides a solid support for collection, storage and subsequent analysis of a biological sample as well as methods for use of the solid support of the invention and a kit comprising the solid support of the invention.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • G01N 1/02 - Devices for withdrawing samples
  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state

38.

SYSTEM HAVING A TUBE SHAFT IMPELLER AND AN ASSOCIATED METHOD THEREOF

      
Application Number EP2020084922
Publication Number 2021/130009
Status In Force
Filing Date 2020-12-07
Publication Date 2021-07-01
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Murugesan, Kandakumar
  • Rao, Nagaraj, Raghavendra
  • Balakrishnan, Saravanan

Abstract

A device (30) includes a base connector (32) having an opening (33) and an impeller connector (64) coupled to the base connector (32). The impeller connector (64) has a through-passage (66) aligned with the opening (33) of the base connector (32). Further, the device (30) includes a flexible tube (34) having a first end (36) and a second end (40), where the first end (36) of the flexible tube (34) is coupled to the impeller connector (64). Furthermore, the device (30) includes a seal component (38) and an impeller (42) coupled to the second end (40) of the flexible tube (34). Additionally, the device (34) includes an enclosure (46) disposed enclosing the impeller (42), the flexible tube (34), the impeller connector (64), and the base connector (32).

IPC Classes  ?

  • B01F 7/16 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a vertical axis
  • B01F 15/00 - Accessories for mixers
  • B01F 15/06 - Heating or cooling systems
  • B01F 3/04 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed gases or vapours with liquids
  • B01F 7/00 - Mixers with rotary stirring devices in fixed receptacles; Kneaders

39.

WHATMAN MASHPREP

      
Serial Number 90707774
Status Registered
Filing Date 2021-05-13
Registration Date 2022-06-07
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory equipment, namely, syringe filters for use with disposable reusable dispenser syringes; laboratory filters

40.

PURADISC

      
Serial Number 90700370
Status Registered
Filing Date 2021-05-10
Registration Date 2023-01-31
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory equipment, namely, syringe filters for use with disposable reusable dispenser syringes; laboratory filters

41.

WHATMAN PURADISC

      
Serial Number 90700446
Status Registered
Filing Date 2021-05-10
Registration Date 2022-07-05
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory equipment, namely, syringe filters for use with disposable reusable dispenser syringes; laboratory filters

42.

REINFORCED COMPONENT FOR CELL CULTIVATION BIOREACTOR

      
Application Number EP2020068356
Publication Number 2021/008867
Status In Force
Filing Date 2020-06-30
Publication Date 2021-01-21
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS USA LLC (USA)
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tuohey, Colin
  • Stankowski, Ralph

Abstract

The present invention relates to a bioprocess bag (118) comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port (142) and at least one outlet port (146). The bioprocess bag (118) also comprises a tube structure (400) comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure (400) comprising a reinforced portion (402) proximate the first opened-end.

IPC Classes  ?

  • B01L 3/02 - Burettes; Pipettes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/06 - Apparatus for enzymology or microbiology with gas introduction means with agitator, e.g. impeller
  • C12M 3/04 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers

43.

IMPROVEMENTS IN AND RELATING TO THE MONITORING OF CELL EXPANSION

      
Document Number 03143275
Status Pending
Filing Date 2020-06-09
Open to Public Date 2020-12-17
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Goodwin, Paul C
  • Bowles, Paul A.
  • Iyer, Rohin K.
  • Gratch, Yarden S.
  • Mccartney, Mitchell M.
  • Yamaguchi, Mei S
  • Davis, Cristina E

Abstract

Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.

IPC Classes  ?

  • C12Q 1/06 - Quantitative determination
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

44.

IMPROVEMENTS IN AND RELATING TO THE MONITORING OF CELL EXPANSION

      
Application Number EP2020065927
Publication Number 2020/249544
Status In Force
Filing Date 2020-06-09
Publication Date 2020-12-17
Owner
  • GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Goodwin, Paul, C
  • Bowles, Paul, Anthony
  • Iyer, Rohin
  • Gratch, Yarden
  • Mccartney, Mitch, M
  • Yamaguchi, Mei, S
  • Davis, Cristina, E

Abstract

Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.

IPC Classes  ?

  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

45.

Device and Method for Sample Isolation

      
Application Number 16607233
Status Pending
Filing Date 2018-04-11
First Publication Date 2020-12-03
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James
  • Pierce, Alan
  • Schenk, Alexander
  • Fullerton, Rebecca Ngaire

Abstract

The present invention relates to a device and method for sample preparation and collection. More closely the invention relates to a device to isolate DNA, RNA and proteins or other biomolecules in one single step from the same undivided sample

IPC Classes  ?

  • G01N 33/538 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip
  • C07K 1/34 - Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
  • C07K 1/36 - Extraction; Separation; Purification by a combination of two or more processes of different types
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01D 69/12 - Composite membranes; Ultra-thin membranes
  • B01D 69/14 - Dynamic membranes

46.

Methods and reagents for reverse-transcription polymerase chain reaction

      
Application Number 15534711
Grant Number 10822645
Status In Force
Filing Date 2017-06-09
First Publication Date 2020-11-03
Grant Date 2020-11-03
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Yarunin, Alexander
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Fullerton, Rebecca

Abstract

The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a polyol, a serum albumin, a non-ionic surfactant and a reducing agent.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
  • C12Q 1/686 - Polymerase chain reaction [PCR]

47.

Micro-needle sampling device and use thereof

      
Application Number 15760062
Grant Number 11229422
Status In Force
Filing Date 2016-10-03
First Publication Date 2020-07-23
Grant Date 2022-01-25
Owner Global Life Sciences Solutions Operations UK Ltd. (United Kingdom)
Inventor
  • Lamerton, Kathryn Louise
  • Smith, Michael John

Abstract

The present invention relates to a device (10) for obtaining a sample (30) from a biological material (40) in solid form, said device comprising an array of micro-needles (30) arranged on a base plate (20). It further relates to a method for obtaining a sample (50) from a biological material (40) in solid form, comprising pressing the micro-needles (30) of the device (10) into said biological material (40), and subsequently removing the device from the biological material (40), and to the use of the device (10) in such a method.

IPC Classes  ?

  • A61B 10/02 - Instruments for taking cell samples or for biopsy
  • G01N 1/08 - Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
  • A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

48.

MASHPREP

      
Serial Number 88927296
Status Registered
Filing Date 2020-05-21
Registration Date 2022-06-07
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

laboratory equipment, namely, syringe filters for use with disposable reusable dispenser syringes

49.

MASHPREP

      
Application Number 202988300
Status Registered
Filing Date 2020-05-21
Registration Date 2023-01-11
Owner Global Life Sciences Solutions Operations UK Limited (United Kingdom)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

(1) Laboratory equipment, namely syringe filters

50.

Electrospun fibers for protein stabilization and storage

      
Application Number 16261532
Grant Number 11555215
Status In Force
Filing Date 2019-01-29
First Publication Date 2019-05-23
Grant Date 2023-01-17
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Li, Bing
  • Moore, David Roger
  • Alberts, William Christopher
  • Nelson, John Richard

Abstract

An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

51.

In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides

      
Application Number 15707074
Grant Number 10350307
Status In Force
Filing Date 2017-09-18
First Publication Date 2019-03-21
Grant Date 2019-07-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Davis, Brian Michael
  • Nelson, John Richard
  • Gao, Wei

Abstract

A method for in vivo RNA or protein expression is provided. The method includes introducing a double-stranded concatemeric DNA into a eukaryotic cell to generate a desired RNA or protein. The double-stranded concatemeric DNA includes a plurality of tandem repeat sequences, wherein each of the plurality of tandem repeat sequences comprises an expression sequence. The double-stranded concatemeric DNA comprises one or more phosphorothioated nucleotides, wherein a ratio of phosphorothioated nucleotides to total nucleotides in the double-stranded concatemeric DNA is at least 1:1600. A eukaryotic cell comprising an exogeneous, double-stranded concatemeric DNA comprising the plurality of tandem repeat sequences is also provided.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

52.

Methods and reagents for reverse-transcription polymerase chain reaction

      
Application Number 15534578
Grant Number 10858694
Status In Force
Filing Date 2015-12-18
First Publication Date 2019-03-14
Grant Date 2020-12-08
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Yarunin, Alexander
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Fullerton, Rebecca

Abstract

The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a) a polar aprotic solvent; b) a serum albumin; and optionally c) a non-ionic surfactant and/or a betaine.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

53.

Cell-free protein expression using rolling circle amplification product

      
Application Number 16041734
Grant Number 11421259
Status In Force
Filing Date 2018-07-20
First Publication Date 2019-03-07
Grant Date 2022-08-23
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12P 21/00 - Preparation of peptides or proteins
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression

54.

Endonuclase-assisted isothermal amplification using contamination-free reagents

      
Application Number 15941057
Grant Number 11268116
Status In Force
Filing Date 2018-03-30
First Publication Date 2019-02-28
Grant Date 2022-03-08
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Duthie, Robert Scott
  • Nelson, John Richard
  • Sekher, Anuradha

Abstract

Disclosed are methods and kits for endonuclease-assisted DNA amplification reaction using decontaminated primer solutions that are pre-treated with a nuclease. Nucleic acid amplification assays that employ nuclease-resistant, inosine-containing primers, endonuclease V enzymes to introduce a nick into a target DNA comprising at least one inosine, and a DNA polymerase to generate amplicons of a target DNA are also disclosed.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

55.

Cell-free protein expression using double-stranded concatameric DNA

      
Application Number 15631510
Grant Number 11001868
Status In Force
Filing Date 2017-08-11
First Publication Date 2019-02-14
Grant Date 2021-05-11
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Nelson, John Richard
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation using a double-stranded concatemeric DNA in a eukaryotic cell-free expression system are provided. The method includes the steps of (a) contacting a double-stranded concatemeric DNA with a eukaryotic cell-free expression system, and (b) expressing a protein in vitro from the double-stranded concatemeric DNA in the eukaryotic cell-free expression system. The double-stranded concatemeric DNA includes a plurality of tandem repeat sequences. The plurality of tandem repeat sequences includes an expression sequence including a promoter, a cap-independent translation element (CITE), and an open reading frame. A final concentration of the double-stranded concatemeric DNA in the eukaryotic cell-free expression system is in a range from about 0.1 ng/μL to about 35 ng/μL. A RCA product DNA may be used as the double stranded concatemer DNA for the methods.

IPC Classes  ?

  • C12P 21/00 - Preparation of peptides or proteins
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

56.

Ethylene oxide treatment indicator, label and method of use

      
Application Number 16078749
Grant Number 11696969
Status In Force
Filing Date 2017-02-28
First Publication Date 2019-02-14
Grant Date 2023-07-11
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor Tatnell, Peter James

Abstract

The present invention provides an indicator useful in confirming successful sterilisation and/or nucleic acid decontamination by ethylene oxide (EtO) treatment. The invention also provides a label comprising said indicator and methods for use of the indicator and label in a method of EtO treatment.

IPC Classes  ?

  • A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
  • A61L 2/20 - Gaseous substances, e.g. vapours
  • G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators

57.

Amplification and detection of nucleic acids

      
Application Number 16036430
Grant Number 11173490
Status In Force
Filing Date 2018-07-16
First Publication Date 2019-01-10
Grant Date 2021-11-16
Owner
  • University of Washington (USA)
  • Global Life Sciences Solutions Operations UK Ltd. (United Kingdom)
Inventor
  • Moore, David Roger
  • Misner, Matthew Jeremiah
  • Burns, Andrew Arthur Paul
  • Bishop, Joshua
  • Lafleur, Lisa K.
  • Wheeler, Maxwell

Abstract

The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

58.

Methods for electroelution of biomolecules

      
Application Number 16012147
Grant Number 11033859
Status In Force
Filing Date 2018-06-19
First Publication Date 2018-12-20
Grant Date 2021-06-15
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Nelson, John Richard
  • Spooner, Patrick Mccoy
  • Lenigk, Ralf
  • Wood, Nicole Lea
  • Zhu, Li
  • Galligan, Craig Patrick

Abstract

A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.

IPC Classes  ?

  • B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

59.

SERASIL-MAG

      
Application Number 193302500
Status Registered
Filing Date 2018-11-29
Registration Date 2022-01-05
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

(1) Laboratory reagents, namely, silica beads for scientific and research use

60.

NGS-PLEX

      
Application Number 193287500
Status Registered
Filing Date 2018-11-28
Registration Date 2022-09-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

(1) Chemical reagents and cell culture reagents for DNA and RNA sequencing for use in genomic research.

61.

NGS-PLEX

      
Application Number 017987879
Status Registered
Filing Date 2018-11-21
Registration Date 2019-03-22
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Reagent kits for DNA and RNA sequencing for use in genomic research.

62.

SERASIL-MAG

      
Application Number 017987877
Status Registered
Filing Date 2018-11-21
Registration Date 2019-03-26
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Laboratory reagents, namely, silica beads for scientific and research use.

63.

SERASIL-MAG

      
Serial Number 88202250
Status Registered
Filing Date 2018-11-21
Registration Date 2019-12-03
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
NICE Classes  ? 01 - Chemical and biological materials for industrial, scientific and agricultural use

Goods & Services

Laboratory reagents, namely, silica beads for scientific and research use

64.

Display screen with a graphical user interface

      
Application Number 29575394
Grant Number D0831683
Status In Force
Filing Date 2016-08-24
First Publication Date 2018-10-23
Grant Date 2018-10-23
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Ghosh, Pratik

65.

Display screen with a graphical user interface

      
Application Number 29575395
Grant Number D0831684
Status In Force
Filing Date 2016-08-24
First Publication Date 2018-10-23
Grant Date 2018-10-23
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Ghosh, Pratik

66.

Method and apparatus for isolating nucleic acids

      
Application Number 15985771
Grant Number 10683496
Status In Force
Filing Date 2018-05-22
First Publication Date 2018-09-20
Grant Date 2020-06-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Chen, Lin
  • Zhang, Bing
  • Hochleitner, Klaus
  • Hou, Rong
  • Wang, Yanju

Abstract

A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
  • C07H 1/06 - Separation; Purification
  • C07H 1/08 - Separation; Purification from natural products
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

67.

METHOD FOR IDENTIFYING EXPRESSION DISTINGUISHERS IN BIOLOGICAL SAMPLES

      
Application Number 15659359
Status Pending
Filing Date 2017-07-25
First Publication Date 2018-09-06
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Newberg, Lee Aaron
  • Kodira, Chinnappa

Abstract

The present techniques provide techniques for determining gene expression distinguishers of biological samples using expression data that comprises signal intensity of signal generators with binding specificity to target molecules. Multiple samples may be analyzed to determine gene expression distinguishers that may be used for identifying cell types or understanding the mechanism of disease progression.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G06F 19/24 - for machine learning, data mining or biostatistics, e.g. pattern finding, knowledge discovery, rule extraction, correlation, clustering or classification
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G06F 19/20 - for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation

68.

Method and kit for analyte detection

      
Application Number 15753343
Grant Number 10907148
Status In Force
Filing Date 2016-08-18
First Publication Date 2018-08-30
Grant Date 2021-02-02
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James

Abstract

The present invention relates to a method and kit for analyte detection. More precisely the invention relates to a method of detecting an analyte, comprising storing short single stranded nucleic acids (10-100 nt), such as aptamers and micro RNA, on a solid support at ambient temperature; and subsequent amplification of said nucleic acids for detection of analyte(s).

IPC Classes  ?

  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase

69.

Ligase-assisted nucleic acid circularization and amplification

      
Application Number 15949061
Grant Number 10655167
Status In Force
Filing Date 2018-04-09
First Publication Date 2018-08-09
Grant Date 2020-05-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Kvam, Erik Leeming
  • Nelson, John Richard

Abstract

Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any intervening purification steps. The single-stranded DNA circle is generated via a template-independent single-stranded DNA ligation. Whole-genome amplification of linear chromosomal DNA in a single tube using ligation-assisted DNA amplification is also provided.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6869 - Methods for sequencing

70.

Display screen with a graphical user interface

      
Application Number 29575396
Grant Number D0822708
Status In Force
Filing Date 2016-08-24
First Publication Date 2018-07-10
Grant Date 2018-07-10
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Ghosh, Pratik

71.

Sample collection and transfer device

      
Application Number 15905226
Grant Number 10675622
Status In Force
Filing Date 2018-02-26
First Publication Date 2018-07-05
Grant Date 2020-06-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lenigk, Ralf
  • Finehout, Erin Jean
  • Wang, Xuefeng

Abstract

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 3/02 - Burettes; Pipettes

72.

Biological sample collectors and handling thereof

      
Application Number 15562696
Grant Number 10955321
Status In Force
Filing Date 2016-03-23
First Publication Date 2018-03-01
Grant Date 2021-03-23
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth
  • Norey, Christopher George
  • Pierce, Alan Stuart
  • John, Robert

Abstract

Disclosed is a biological sample collector 500 comprising a solid support 12 having plural discrete areas (22, 24, 26, 28 FIG. 1) for accepting a biological sample, each area being chemically differentiated, for example by having a different chemical treatment sorbed onto the solid support. An envelope 530 encloses the solid support. A cover portion 520 can cover the biological sample after collection to prevent infection. UV light can be applied to the collected sample to reduce the risk of infection.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

73.

Devices for separation of particulates, associated methods and systems

      
Application Number 15209411
Grant Number 10518196
Status In Force
Filing Date 2016-07-13
First Publication Date 2018-01-04
Grant Date 2019-12-31
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Puleo, Christopher Michael
  • Galligan, Craig Patrick
  • Grossman, Gregory Andrew
  • Kvam, Erik Leeming
  • Duthie, Robert Scott
  • Rigby, Kenneth Wayne
  • Smigelski, Jr., Paul Michael
  • Cotero, Victoria Eugenia
  • Castle, Jason William
  • Burczak, John Donald
  • Rothman, James Edward

Abstract

A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.

IPC Classes  ?

  • B01D 21/00 - Separation of suspended solid particles from liquids by sedimentation
  • B01D 21/24 - Feed or discharge mechanisms for settling tanks
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/40 - Concentrating samples
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
  • C12M 1/26 - Inoculator or sampler
  • B01D 17/02 - Separation of non-miscible liquids
  • B01D 21/02 - Settling tanks
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C02F 1/48 - Treatment of water, waste water, or sewage with magnetic or electric fields
  • C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
  • C02F 101/32 - Hydrocarbons, e.g. oil

74.

High capacity redox electrodes and their use in cell lysis

      
Application Number 15532233
Grant Number 11402349
Status In Force
Filing Date 2015-12-03
First Publication Date 2017-12-21
Grant Date 2022-08-02
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Peters, Andrea Jeannine
  • Stecher, Thomas Elliot
  • Galligan, Craig Patrick
  • Puleo, Christopher Michael
  • Lenigk, Ralf

Abstract

The present disclosure relates to the manufacture and use of redox electrodes and their use in cell lysis. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 Volts.

IPC Classes  ?

  • G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • H01G 9/042 - Electrodes characterised by the material
  • H01G 9/22 - Devices using combined reduction and oxidation, e.g. redox arrangement or solion
  • H01G 11/02 - Hybrid capacitors, i.e. capacitors having different positive and negative electrodes; Electric double-layer [EDL] capacitors; Processes for the manufacture thereof or of parts thereof using combined reduction-oxidation reactions, e.g. redox arrangement or solion
  • H01G 11/28 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features arranged or disposed on a current collector; Layers or phases between electrodes and current collectors, e.g. adhesives
  • H01G 11/48 - Conductive polymers
  • H01G 11/86 - Processes for the manufacture of hybrid or EDL capacitors, or components thereof specially adapted for electrodes
  • G01N 27/453 - Cells therefor
  • H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds

75.

Devices, methods and systems for collecting waste from a bioreactor

      
Application Number 15529567
Grant Number 10227554
Status In Force
Filing Date 2015-12-15
First Publication Date 2017-11-23
Grant Date 2019-03-12
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Janas, Michelle Louise

Abstract

The invention relates to devices, methods and systems for collecting and solidifying waste material from bioreactor cell cultures in order to facilitate waste disposal. The invention finds particular utility in mammalian cell culture applications. A transverse wall divides the interior of a waste bag into two chambers, the first chamber containing an inlet receiving waste liquid from a bioreactor, the second chamber containing an absorbent material to solidify the liquid into a gel. The transverse wall acts to direct the flow of waste media into the second chamber where it is converted into a gel and further prevents the inlet from being blocked by any gel or particulate materials. Methods and uses regarding this invention are described.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology

76.

Methods and reagents for reverse-transcription polymerase chain reaction

      
Application Number 15533714
Grant Number 10968478
Status In Force
Filing Date 2015-12-18
First Publication Date 2017-11-09
Grant Date 2021-04-06
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Yarunin, Alexander
  • Tatnell, Peter James
  • Lamerton, Kathryn Louise
  • Fullerton, Rebecca Ngaire

Abstract

The present invention provides a method of amplifying an RNA molecule in a biological sample by reverse transcription PCR (RT-PCR), wherein the RT-PCR is carried out in a solution comprising a polar aprotic solvent; a serum albumin, and a polyol.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C07H 1/00 - Processes for the preparation of sugar derivatives
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

77.

Cell-free protein expression using rolling circle amplification product

      
Application Number 15145838
Grant Number 10077459
Status In Force
Filing Date 2016-05-04
First Publication Date 2017-11-09
Grant Date 2018-09-18
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Nelson, John Richard
  • Duthie, Robert Scott
  • Kvam, Erik Leeming
  • Gao, Wei

Abstract

Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system.

IPC Classes  ?

  • C12P 21/00 - Preparation of peptides or proteins
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/67 - General methods for enhancing the expression

78.

Composition and method for imaging stem cells

      
Application Number 15631124
Grant Number 10920287
Status In Force
Filing Date 2017-06-23
First Publication Date 2017-10-19
Grant Date 2021-02-16
Owner
  • Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
  • The Board of Trustees of the Leland Stanford Junior University (USA)
Inventor
  • Bhaumik, Srabani
  • Gambhir, Sanjiv Sam
  • Paulmurugan, Ramasamy
  • Yaghoubi, Shahriar
  • Ahn, Byeong-Cheol
  • Parashurama, Natesh

Abstract

An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more of the cells differentiate or dedifferentiate. Methods and kits for imaging and monitoring stem cells comprising the expression vector are also provided.

IPC Classes  ?

  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

79.

Analyte detection on a solid support by nucleic acid amplification coupled to an immunoassay

      
Application Number 15529597
Grant Number 11008604
Status In Force
Filing Date 2015-12-08
First Publication Date 2017-09-14
Grant Date 2021-05-18
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Lamerton, Kathryn Louise
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James

Abstract

Embodiments of the invention provides a method for detection of at least one analyte derived from a sample, comprising the steps of: a) depositing the sample on a surface of a solid support; b) transferring at least a portion of the solid support to a receptacle suitable for performing a specific binding assay for one or more analytes of interest; c) optionally washing the portion; d) adding a single specific binding partner for each analyte of interest to the receptacle, the binding partner being labelled with an oligonucleotide sequence; e) mixing the portion with nucleic acid amplification reagents; f) amplifying the oligonucleotide sequence; and g) detecting amplified nucleic acid. The invention also provides a kit for use with the method for detection of at least one analyte derived from a sample.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • C12Q 1/6804 - Nucleic acid analysis using immunogens
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6851 - Quantitative amplification

80.

Method and composition for biomolecule stabilization

      
Application Number 15429760
Grant Number 10590408
Status In Force
Filing Date 2017-02-10
First Publication Date 2017-08-24
Grant Date 2020-03-17
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Ashman, Elizabeth Mary

Abstract

The present invention relates to biomolecule stabilization to provide biomolecules, such as sensitive polymerases, in a convenient ready-to-go format. The invention provides a method and composition in which non-ionic surfactant or detergents of the polyoxyethylene cetyl ether family are used, preferably a Brij reagent or a combination of Brij reagents.

IPC Classes  ?

  • C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12Q 1/686 - Polymerase chain reaction [PCR]

81.

Screening and monitoring the progression of type 2 diabetes by the molecular identification of human gut flora using FTA as a faecal collection device

      
Application Number 15326382
Grant Number 10982290
Status In Force
Filing Date 2015-07-23
First Publication Date 2017-07-27
Grant Date 2021-04-20
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James
  • Morrison, Matthew Sam
  • Pierce, Alan Stuart

Abstract

Disclosed is a method for detecting and quantifying gut flora derived from human faeces, comprising acquiring a solid support containing human faeces; optionally amplifying nucleic acid from the human faeces; and detecting and quantifying the presence of gut flora of interest. Also disclosed is a method for assessing whether a person has type-2 diabetes as well as a kit for detecting and quantifying gut flora from human faeces, comprising a solid support for collecting human faeces; and primer pairs for amplifying 16S rRNA sequence from bacteria of interest.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/10 - Enterobacteria
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • C12Q 1/06 - Quantitative determination
  • A61K 38/00 - Medicinal preparations containing peptides
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

82.

Method and device for collection and amplification of circulating nucleic acids

      
Application Number 15463943
Grant Number 11142758
Status In Force
Filing Date 2017-03-20
First Publication Date 2017-07-27
Grant Date 2021-10-12
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Nelson, John Richard
  • Grossmann, Gregory Andrew
  • Heller, Ryan Charles
  • Finehout, Erin Jean
  • Puleo, Christopher Michael
  • Waters, William Patrick

Abstract

Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

83.

Sample collection and transfer device

      
Application Number 15326412
Grant Number 10350592
Status In Force
Filing Date 2015-07-20
First Publication Date 2017-07-20
Grant Date 2019-07-16
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Lenigk, Ralf
  • Finehout, Erin Jean
  • Wang, Xuefeng

Abstract

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • A61B 5/15 - Devices for taking samples of blood
  • G01N 1/14 - Suction devices, e.g. pumps; Ejector devices
  • B01L 3/02 - Burettes; Pipettes

84.

Oligonucleotide data storage on solid supports

      
Application Number 15102209
Grant Number 11931713
Status In Force
Filing Date 2014-11-26
First Publication Date 2017-06-01
Grant Date 2024-03-19
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Tatnell, Peter James
  • Stone, Robert

Abstract

A data storage medium is disclosed comprising a solid support matrix including an optional stabilising reagent or reagents in a dry form, for use as a support for artificially synthesised oligonucleotide sequences encoded with data. Preferably the matrix is fibrous (for example cellulose, or glass, fibres) formed into a support of sufficient strength to hold the oligonucleotide sequences. The stabilising reagents are preferably a combination of a weak base, and a chelating agent, optionally, uric acid or a urate salt, and optionally an anionic surfactant.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]

85.

Direct nucleic acid amplification kit, reagent and method

      
Application Number 15432476
Grant Number 10907201
Status In Force
Filing Date 2017-02-14
First Publication Date 2017-06-01
Grant Date 2021-02-02
Owner Global Life Sciences Solutions Operations UK Ltd (United Kingdom)
Inventor
  • Horton, Jeffrey K.
  • Tatnell, Peter J.
  • Lamerton, Kathryn L.

Abstract

The present invention relates to compositions, methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. The dried reagent composition of the invention can be used for easy processing and amplification of nucleic acid samples.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

86.

Device and method of collection for RNA viruses

      
Application Number 14945483
Grant Number 10000742
Status In Force
Filing Date 2015-11-19
First Publication Date 2017-05-25
Grant Date 2018-06-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kvam, Erik Leeming
  • Duthie, Robert Scott
  • Nelson, John Richard

Abstract

The present disclosure generally relates to a method and device for inactivation and dry storage, under ambient conditions, of a biological sample containing RNA virus. Methods for collecting and recovering RNA from a biological sample and subsequent analysis for a virus are also provided.

IPC Classes  ?

  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

87.

Solid phase isothermal amplification

      
Application Number 15419560
Grant Number 10443094
Status In Force
Filing Date 2017-01-30
First Publication Date 2017-05-18
Grant Date 2019-10-15
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard
  • Patel, Paresh Lakhubhai
  • Wakefield, Alison Myfanwy
  • Capper, Stephen James
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth

Abstract

m) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

88.

Device and method for cell nuclei preparation

      
Application Number 15317039
Grant Number 10370649
Status In Force
Filing Date 2015-06-17
First Publication Date 2017-05-04
Grant Date 2019-08-06
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kenrick, Michael Kenneth
  • Seymour, Geraint

Abstract

The present invention relates to the field of nucleic acid collection and storage, and in particular to the collection and long-term storage of nuclei. The invention provides a device and method which can be used to capture and store nuclei at ambient temperatures allowing the subsequent isolation of nucleic acids by passive washing with a wash buffer. The present invention also provides a kit including the device of the invention suitable for carrying out the method of the invention.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

89.

Isothermal amplification under low salt condition

      
Application Number 15408509
Grant Number 10597691
Status In Force
Filing Date 2017-01-18
First Publication Date 2017-05-04
Grant Date 2020-03-24
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard
  • Patel, Paresh Lakhubhai
  • Wakefield, Alison Myfanwy
  • Capper, Stephen James

Abstract

m) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C12Q 1/6844 - Nucleic acid amplification reactions

90.

Biological sample collection device

      
Application Number 15349638
Grant Number 10271825
Status In Force
Filing Date 2016-11-11
First Publication Date 2017-05-04
Grant Date 2019-04-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Pierce, Alan Stuart
  • Potts, Cheryl Louise
  • Stubbs, Simon Laurence John
  • Treharne, David Gwyn

Abstract

Methods of using a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • A61B 5/15 - Devices for taking samples of blood

91.

Processed biological sample storage

      
Application Number 15119065
Grant Number 10392651
Status In Force
Filing Date 2015-02-20
First Publication Date 2017-02-23
Grant Date 2019-08-27
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor Moran, Nina

Abstract

A fluidic device is disclosed for processing a biological sample in order to extract nucleic acids contained in said sample and for subsequently amplifying said extracted nucleic acids, said device including a processed sample storage archive area 10 comprising an absorbent solid substrate 14 treated with at least one nucleic acid stabilizing reagent or reagent mix, said substrate allowing the generally dry and stabilized storage of said extracted and/or amplified nucleic acids, for example for long term storage of biological samples recovered forensically.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • B01L 9/00 - Supporting devices; Holding devices

92.

Amplification and detection of nucleic acids

      
Application Number 14807497
Grant Number 10040069
Status In Force
Filing Date 2015-07-23
First Publication Date 2017-01-26
Grant Date 2018-08-07
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Moore, David Roger
  • Misner, Matthew Jeremiah
  • Burns, Andrew Arthur Paul
  • Bishop, Joshua
  • Lafleur, Lisa K.
  • Wheeler, Maxwell

Abstract

The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

93.

Substrates and methods for collection, stabilization and elution of biomolecules

      
Application Number 15285986
Grant Number 10625242
Status In Force
Filing Date 2016-10-05
First Publication Date 2017-01-26
Grant Date 2020-04-21
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Kovacs, Ernest William
  • Mondello, Frank John
  • Kvam, Erik Leeming
  • Li, Bing

Abstract

A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.

IPC Classes  ?

  • C12N 9/38 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-galactose-glycoside bonds, e.g. beta-galactosidase
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
  • C07K 1/16 - Extraction; Separation; Purification by chromatography
  • C07K 1/14 - Extraction; Separation; Purification
  • C07K 14/54 - Interleukins (IL)
  • C07K 14/525 - Tumour necrosis factor (TNF)
  • C07K 14/545 - IL-1
  • C07K 14/775 - Apolipopeptides
  • B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/32 - Impregnating or coating

94.

Microfluidic devices and arrangements for introducing reagents and biological samples to such devices

      
Application Number 15121147
Grant Number 10252265
Status In Force
Filing Date 2015-02-20
First Publication Date 2016-12-22
Grant Date 2019-04-09
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Tatnell, Peter James
  • Horton, Jeffrey Kenneth
  • Seymour, Geraint

Abstract

A microfluidic device 100 is disclosed comprising a body 112 including a biological sample S and/or reagent R receiving slot 122. The sample and reagent are carried on a solid support 10. The device 100 includes two punch assemblies 130 for removing portions of the solid support 10 and delivering them, together with the sample and/or reagent(s), to a receiving chamber 126 for subsequent processing. The device can be used for various assays including those which require just the addition of water in the reaction chamber with no pre-treatment of sample prior delivery into the chamber.

IPC Classes  ?

  • G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/28 - Preparing specimens for investigation

95.

Method and apparatus for isolating nucleic acids

      
Application Number 15231082
Grant Number 10000751
Status In Force
Filing Date 2016-08-08
First Publication Date 2016-11-24
Grant Date 2018-06-19
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Chen, Lin
  • Zhang, Bing
  • Hochleitner, Klaus
  • Hou, Rong
  • Wang, Yanju

Abstract

A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
  • B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
  • C07H 1/06 - Separation; Purification
  • C07H 1/08 - Separation; Purification from natural products
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

96.

MICROFLUIDIC DEVICES AND ARRANGEMENTS FOR SUPPLYING SUCH DEVICES WITH REAGENTS AND BIOLOGICAL SAMPLES

      
Application Number 15030994
Status Pending
Filing Date 2014-10-08
First Publication Date 2016-10-20
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Horton, Jeffrey Kenneth
  • Stubbs, Simon Laurence John
  • Tatnell, Peter James
  • Seymour, Geraint
  • Potts, Cheryl Louise
  • Pierce, Alan Stuart
  • Powell, David
  • Wakefield, Alison Myfanwy

Abstract

Disclosed is a microfluidic device including a reagent supply apparatus comprising: a solid support 12 formed preferably from cellulose fibrous material having a porosity which allows liquid flow through the material; at least one generally dry reagent 16 stored on a surface of the support at a regent location or locations; the support further being suitable for storing biological sample material 17 in a dry state at a sample location or locations, spaced from the reagent location or locations.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

97.

Controlled transfer biological sample collection devices and methods of using such devices

      
Application Number 15101113
Grant Number 10085726
Status In Force
Filing Date 2014-11-25
First Publication Date 2016-10-20
Grant Date 2018-10-02
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Potts, Cheryl Louise
  • Tatnell, Peter James
  • Seymour, Geraint
  • Pierce, Alan Stuart
  • Smith, Michael John
  • Ogden, Samantha Jane
  • Williams, Neil John
  • Burrows, Christopher
  • Evans, Jared William Harris
  • Bryant, Ashley Edward
  • Sweeney, Sean Robert

Abstract

A controlled transfer biological sample material collection device is disclosed which comprises: a body; and a sample collection member for collecting the biological sample material (not shown), the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position (shown in FIG. 8) where collection of a biological sample is possible, to a transfer position (shown in FIG. 9) which effects transfer of at least a portion of the collected sample to said medium. The device is characterized in that the body slideably supports the sample collection member, and in that the body or collection member include a ramp-like projection portion (116 FIG. 10) operable to force the collection member into the transfer position against the medium and to effect said transfer as the collection member slides within the body.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • B65D 81/00 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/24 - Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganism
  • G01N 1/30 - Staining; Impregnating

98.

Methods and systems for processing samples on porous substrates

      
Application Number 14992859
Grant Number 10365190
Status In Force
Filing Date 2016-01-11
First Publication Date 2016-09-29
Grant Date 2019-07-30
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Shoemaker, Philip Alexander
  • Griffin, Weston Blaine
  • Finehout, Erin Jean
  • Wang, Xuefeng
  • Shaikh, Kashan Ali
  • Goddard, Greg Darryl

Abstract

Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 1/40 - Concentrating samples
  • G01N 30/72 - Mass spectrometers
  • G01N 1/34 - Purifying; Cleaning
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
  • G01N 30/06 - Preparation

99.

Isothermal amplification using oligocation-conjugated primer sequences

      
Application Number 15177149
Grant Number 09920359
Status In Force
Filing Date 2016-06-08
First Publication Date 2016-09-29
Grant Date 2018-03-20
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • Heller, Ryan Charles
  • Nelson, John Richard

Abstract

Provided herein are methods and kits for isothermal nucleic acid amplifications that use an oligocation-oligonucleotide conjugate primer for amplifying a target nucleic acid to generate amplicons. Isothermal DNA amplification methods that employ a strand displacing DNA polymerase and polyamine-oligonucleotide conjugate primer are also provided.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes

100.

Solid medium for the storage of biological material

      
Application Number 15175478
Grant Number 10196675
Status In Force
Filing Date 2016-06-07
First Publication Date 2016-09-22
Grant Date 2019-02-05
Owner GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD (United Kingdom)
Inventor
  • James, Martin D.
  • Horton, Jeffrey K.
  • Tatnell, Peter J.

Abstract

This invention relates to flat solid media for the storage of samples of biological materials and methods of analyzing biomolecules contained within the samples following storage. In particular, the invention relates to the storage and further analysis of biomolecules present in the biological materials, such as proteins, enzymes and nucleic acids. The invention finds particular utility in the dry, room temperature storage of biological materials.

IPC Classes  ?

  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • A01N 1/02 - Preservation of living parts
  • C12N 9/22 - Ribonucleases
  • C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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