Alfred E. Mann Foundation for Scientific Research

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A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers 49
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode 34
A61N 1/372 - Arrangements in connection with the implantation of stimulators 31
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1.

ELECTRODE LEADS HAVING NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS

      
Application Number 18468730
Status Pending
Filing Date 2023-09-17
First Publication Date 2024-04-04
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Trivedi, Hemang
  • Brandt, William Andrew
  • Elyahoodayan, Sahar
  • Jenney, Christopher Reed

Abstract

An electrode lead includes an elongate lead body and a nerve cuff. The nerve cuff may include a cuff body, with a front layer and a rear layer, affixed to the distal end of the lead body and a plurality of electrically conductive members located between the front and rear layers. Each of the electrically conductive member defines a front side, a rear side and an outer perimeter and may include a plurality of holes that extend from the front side to the rear side and that are located around the outer perimeter. The cuff body front layer includes a plurality of windows that are respectively aligned with and located inwardly of the outer perimeters of the electrically conductive members, and a plurality of window frames that extend from the windows to the outer perimeters of the electrically conductive members. The cuff body also includes a plurality of anchors that respectively extend through the electrically conductive member holes and connect the window frames to the cuff body rear layer.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

2.

WAKE-ABLE ELECTRONIC DEVICE AND METHODS FOR WAKING THEREOF

      
Application Number 18477435
Status Pending
Filing Date 2023-09-28
First Publication Date 2024-04-04
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Brydle, Jeffrey A.
  • Shelton, Brian
  • Dearden, Brian
  • Dai, Rongqing

Abstract

An electronic device, includes: a battery; a microcontroller configured to receive power from the battery along a first path comprising a first battery switch configured to change between an opened configuration and a closed configuration; and a receiver coil configured, in response to being positioned in a changing magnetic field, to generate an alternating electric current and to change, via the alternating electric current, the first battery switch from the opened configuration to the closed configuration.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • G01R 31/396 - Acquisition or processing of data for testing or for monitoring individual cells or groups of cells within a battery
  • H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type

3.

SELF-EXPANDING NERVE CUFF ELECTRODE

      
Application Number 18508061
Status Pending
Filing Date 2023-11-13
First Publication Date 2024-03-14
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Ng, Boon Khai
  • Dai, William Alexander

Abstract

An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof

4.

SYSTEMS AND METHODS OF DEDUPLICATING DATA COLLECTED BY AN IMPLANTABLE MEDICAL DEVICE

      
Application Number 18462156
Status Pending
Filing Date 2023-09-06
First Publication Date 2024-03-07
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Hotlani, Hitesh

Abstract

An implantable medical device and a method of deduplicating data collected by the implantable medical device are provided. The method includes storing data, captured by the implantable medical device, in a non-volatile memory device of the implantable medical device, assigning a unique number, generated from a random number generator or counter, to each data block of the data, and deduplicating the data by deleting at least one of two or more data blocks that are associated with the same unique number.

IPC Classes  ?

  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
  • A61N 1/02 - Electrotherapy; Circuits therefor - Details
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

5.

ELECTRODE LEADS HAVING MULTI-APPLICATION HELICAL NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS

      
Application Number 18495503
Status Pending
Filing Date 2023-10-26
First Publication Date 2024-02-22
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Brandt, William Andrew
  • Dearden, Brian Ralph

Abstract

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

6.

NEUROSTIMULATORS AND STIMULATION SYSTEMS

      
Application Number 18376801
Status Pending
Filing Date 2023-10-04
First Publication Date 2024-02-01
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Suri, Harshit
  • Lee, Edward K. F.

Abstract

In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/02 - Electrotherapy; Circuits therefor - Details
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

7.

IMPLANTABLE MEDICAL DEVICE HAVING AN INERTIAL SENSING UNIT

      
Application Number 18358489
Status Pending
Filing Date 2023-07-25
First Publication Date 2024-02-01
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Shelton, Brian
  • Mech, Brian
  • Elyahoodayan, Sahar

Abstract

A stimulation system configured to be implanted in a patient includes an implantable pulse generator (IPG) and an implantable lead system. The IPG includes a processor, a memory device, a power supply, and an inertial sensing unit configured to measure one or more physiological indicators of the patient. The implantable lead system includes at least one electrical lead coupled to the power supply and at least one electrode at a distal end of the electrical lead. The memory device includes instructions that cause the IPG to receive the physiological indicators within an initial range; increase the initial range to an enlarged range in response to the physiological indicators crossing a threshold maximum value or a threshold minimum value of the initial range; receive the physiological signals within the enlarged range, analyze the physiological indicators, and deliver stimulation to the patient through the electrode in response to the physiological indicators.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

8.

TISSUE STIMULATION APPARATUS AND METHODS OF MAKING THE SAME

      
Application Number 18186927
Status Pending
Filing Date 2023-03-20
First Publication Date 2024-01-11
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Jenney, Christopher Reed
  • Talbot, Neil
  • Calderon, Joseph L.
  • Elyahoodayan, Sahar
  • Brandt, William Andrew

Abstract

A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

9.

VAGUS NERVE STIMULATION PUPILLOMETRY FOR ELECTRODE SELECTION AND TITRATION

      
Application Number 18180591
Status Pending
Filing Date 2023-03-08
First Publication Date 2023-12-21
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH, THE (USA)
Inventor
  • Shelton, Brian Michael
  • Mech, Brian
  • Klein, Valma
  • Talbot, Neil
  • Greenberg, Robert

Abstract

The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g., stimulation pulse amplitude) to levels that cause a therapeutic result in a matter of minutes instead of months as compared to related VNS systems.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

10.

STIMULATOR SYSTEMS AND METHODS FOR SELECTIVELY RECRUITING FASCICLES IN HYPOGLOSSAL NERVE TRUNK

      
Application Number 18242254
Status Pending
Filing Date 2023-09-05
First Publication Date 2023-12-21
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Ng, Boon Khai
  • Calderon, Joseph L.

Abstract

An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

11.

DEVICES AND METHODS FOR STIMULATING AN AURICULAR BRANCH OF A VAGUS NERVE

      
Application Number 18170199
Status Pending
Filing Date 2023-02-16
First Publication Date 2023-12-07
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Shelton, Brian Michael
  • Talbot, Neil
  • Dearden, Brian

Abstract

A stimulation device includes a first transmitting coil and a drive circuit electrically coupled to the first transmitting coil and configured to drive the first transmitting coil. The first transmitting coil is configured, when the device is in proximity to a person's ear and the first transmitting coil is driven with a time-varying electric current providable by the drive circuit, to generate at least part of a magnetic field providing a time-varying magnetic flux across an auricular branch of a Vagus Nerve (ABVN) sufficient to activate the ABVN.

IPC Classes  ?

  • A61N 2/00 - Magnetotherapy
  • H01F 7/06 - Electromagnets; Actuators including electromagnets
  • A61N 2/02 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

12.

AUTOMATIC TITRATION FOR VAGUS NERVE STIMULATION

      
Application Number 18193386
Status Pending
Filing Date 2023-03-30
First Publication Date 2023-10-12
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Shelton, Brian Michael
  • Mech, Brian
  • Klein, Valma
  • Talbot, Neil
  • Hotlani, Hitesh

Abstract

The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

13.

AUTOMATICALLY-ALIGNING MAGNETIC FIELD SYSTEM AND METHOD OF FABRICATION

      
Application Number 18178414
Status Pending
Filing Date 2023-03-03
First Publication Date 2023-10-12
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Lin, Susanna
  • Dearden, Brian R.
  • Loo, Justin Cheng-Tsu

Abstract

A wireless power transfer device includes a first transmitting coil oriented along a first axis and including a first ferrite rod; a second transmitting coil on the first transmitting coil, oriented along a second axis different from the first axis, and including a second ferrite rod; and a nonmagnetic layer magnetically decoupling the first ferrite rod from the second ferrite rod in an area of overlap between the first and second ferrite rods, the first ferrite rod and the nonmagnetic layer being fabricated utilizing additive manufacturing.

IPC Classes  ?

  • B22F 12/41 - Radiation means characterised by the type, e.g. laser or electron beam
  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • B22F 10/25 - Direct deposition of metal particles, e.g. direct metal deposition [DMD] or laser engineered net shaping [LENS]
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling

14.

SYSTEMS AND METHODS FOR VAGUS NERVE STIMULATION

      
Application Number 18194217
Status Pending
Filing Date 2023-03-31
First Publication Date 2023-10-05
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Shelton, Brian Michael
  • Hotlani, Hitesh

Abstract

The disclosure provides systems and methods for system for vagus nerve stimulation (VNS), using a VNS stimulator implanted in a human subject and configured to transmit electrical stimulation pulses to a vagus nerve of the human subject; and at least one sensor configured to detect a predefined pattern of tactile input, a bodily gesture, and/or a voice command from the human subject, wherein the VNS stimulator includes a controller configured to modulate at least one stimulation parameter of the electrical stimulation pulses based at least in part on the tactile input, bodily gesture, and/or voice command from the human subject.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/02 - Electrotherapy; Circuits therefor - Details

15.

IMPLANTABLE MEDICAL DEVICE CHARGERS AND CHARGER POSITIONING SUPPORTS FOR USE WITH SAME

      
Application Number 18175522
Status Pending
Filing Date 2023-02-27
First Publication Date 2023-09-21
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Calderon, Joseph L.
  • Hillery, Edward
  • Lin, Susanna M.

Abstract

An implantable medical device (IMD) charger apparatus may include an IMD charger including a housing defining a bottom surface, a primary coil located within the housing, and a fastener on the bottom surface of the housing, and a charger support, mounted on the IMD charger, including a bottom surface, and movable between a first state and a second state. The IMD charger and the charger support may be respectively configured such that the IMD charger fastener is above the charger support bottom surface when the charger support is in the first state and the IMD charger fastener is at or below the charger support bottom surface when the charger support is in the second state.

IPC Classes  ?

  • A61N 1/378 - Electrical supply
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment

16.

AUTOMATICALLY-ALIGNING MAGNETIC FIELD SYSTEM

      
Application Number 18179821
Status Pending
Filing Date 2023-03-07
First Publication Date 2023-09-21
Owner The Alfred E Mann Foundation for Scientific Research (USA)
Inventor
  • Farkas, Leslie G.
  • Dearden, Brian R.
  • Loo, Justin Cheng-Tsu

Abstract

A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.

IPC Classes  ?

  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
  • H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
  • H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
  • H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment

17.

SYSTEMS AND METHODS FOR VAGUS NERVE MONITORING AND STIMULATION

      
Application Number 18167041
Status Pending
Filing Date 2023-02-09
First Publication Date 2023-08-10
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Mech, Brian V.
  • Talbot, Neil
  • Shelton, Brian M.
  • Calderon, Joseph L.
  • Greenberg, Robert J.

Abstract

The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g., epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g., vagal tone and/or physiological or other biomarkers).

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/369 - Electroencephalography [EEG]

18.

Pressure sensors with tensioned membranes

      
Application Number 18132331
Grant Number 11953399
Status In Force
Filing Date 2023-04-07
First Publication Date 2023-08-03
Grant Date 2024-04-09
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schmidt, Siegmar
  • Dai, William A.
  • Ng, Boon Khai

Abstract

Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.

IPC Classes  ?

  • G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
  • G01L 7/08 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges of the flexible-diaphragm type
  • G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
  • G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
  • G01L 19/04 - Means for compensating for effects of changes of temperature
  • G01L 19/06 - Means for preventing overload or deleterious influence of the measured medium on the measuring device or vice versa
  • G01L 19/14 - Housings

19.

STIMULATOR SYSTEMS AND METHODS FOR OBSTRUCTIVE SLEEP APNEA

      
Application Number 18296805
Status Pending
Filing Date 2023-04-06
First Publication Date 2023-08-03
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Suri, Harshit
  • Calderon, Joseph L.
  • Molnar, Gregory Frederick
  • Goding, Jr., George S.
  • Atyabi, Alanie
  • Schmidt, Siegmar
  • Dai, William
  • Dearden, Brian
  • Keenan, Desmond B.

Abstract

An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
  • A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
  • A61B 5/087 - Measuring breath flow
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/378 - Electrical supply
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61B 5/394 - Electromyography [EMG] specially adapted for electroglottography or electropalatography

20.

ELECTRODE LEADS HAVING NERVE CONTACT ELEMENTS WITH COIL CONTACTS AND ASSOCIATED SYSTEMS AND METHODS

      
Application Number 17710570
Status Pending
Filing Date 2022-03-31
First Publication Date 2023-08-03
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Jenney, Christopher Reed
  • Strickland, Timothy

Abstract

An electrode lead including an elongate lead body and a nerve cuff (or other nerve contact element) including an electrically insulative cuff body (or other contact body) affixed to the distal end of the lead body and at least one electrically conductive coil partially embedded in the cuff body (or other contact body) such that there are non-embedded portions, which together define a flexible coil contact that is associated with the front outer surface of the cuff body (or other contact body), and embedded portions.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

21.

METHOD AND APPARATUS FOR PRE-ALIGNMENT OF AN AUTOMATICALLY ALIGNING MAGNETIC FIELD SYSTEM

      
Application Number 18153991
Status Pending
Filing Date 2023-01-12
First Publication Date 2023-07-27
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian
  • Shelton, Brian
  • Farkas, Leslie G.

Abstract

A wireless power transfer system includes a wireless power transfer device configured to determine a magnetic field, from among a plurality of directionally different potential magnetic fields that the wireless power transfer device is configured to generate, that has, at a receiver coil of an electronic device, a direction aligned with the receiver coil.

IPC Classes  ?

  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
  • H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
  • G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof
  • G01P 15/02 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces

22.

Electrode leads having multi-application helical nerve cuffs and associated systems and methods

      
Application Number 17463630
Grant Number 11833348
Status In Force
Filing Date 2021-09-01
First Publication Date 2023-01-12
Grant Date 2023-12-05
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Brandt, William Andrew
  • Dearden, Brian Ralph

Abstract

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

23.

VIBRATORY NEUROMODULATION

      
Application Number 17736726
Status Pending
Filing Date 2022-05-04
First Publication Date 2022-11-10
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Mech, Brian
  • Greenberg, Robert

Abstract

The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.

IPC Classes  ?

  • A61N 1/04 - Electrodes
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

24.

Nerve cuff electrodes fabricated using over-molded LCP substrates

      
Application Number 17807370
Grant Number 11951302
Status In Force
Filing Date 2022-06-16
First Publication Date 2022-10-13
Grant Date 2024-04-09
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schmidt, Siegmar
  • Ng, Boon Khai

Abstract

An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • A61B 5/389 - Electromyography [EMG]

25.

ELECTRODE LEADS HAVING NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS

      
Application Number 17683598
Status Pending
Filing Date 2022-03-01
First Publication Date 2022-10-06
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Jenney, Christopher Reed
  • Gotlib, Oren
  • Calderon, Joseph
  • Brandt, William Andrew
  • Talbot, Neil

Abstract

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • H01R 13/52 - Dustproof, splashproof, drip-proof, waterproof, or flameproof cases

26.

Nerve cuff electrodes fabricated using over-molded LCP substrates

      
Application Number 17807349
Grant Number 11951301
Status In Force
Filing Date 2022-06-16
First Publication Date 2022-09-29
Grant Date 2024-04-09
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schmidt, Siegmar
  • Ng, Boon Khai

Abstract

An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • A61B 5/389 - Electromyography [EMG]

27.

PHOTOPLETHYSMOGRAPHY IN COMBINATION WITH MEDICAL DEVICES

      
Application Number 17692761
Status Pending
Filing Date 2022-03-11
First Publication Date 2022-09-15
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Mech, Brian
  • Greenberg, Robert

Abstract

The disclosure provides systems and methods for detecting, monitoring, and/or treating obstructive sleep apnea, as well as other conditions, using vital sign and/or biometric data collected and/or imputed from one or more photoplethysmography sensors in conjunction with vital sign and/or biometric data from one or more additional sensors such as activity, body position, ECG, HR, or SpO2 levels, e.g., as feedback to control therapy and/or to titrate therapy on a periodic basis.

IPC Classes  ?

  • A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/362 - Heart stimulators

28.

System and method for authenticating wireless programming devices in programmable medical systems

      
Application Number 17664360
Grant Number 11805413
Status In Force
Filing Date 2022-05-20
First Publication Date 2022-09-08
Grant Date 2023-10-31
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIC RESEARCH (USA)
Inventor
  • Rodriguez, Saul
  • Han, Dianna (dan)
  • Istoc, Emil

Abstract

A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.

IPC Classes  ?

  • H04L 29/06 - Communication control; Communication processing characterised by a protocol
  • H04W 12/06 - Authentication
  • H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
  • H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
  • H04L 9/40 - Network security protocols
  • H04L 69/40 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass for recovering from a failure of a protocol instance or entity, e.g. service redundancy protocols, protocol state redundancy or protocol service redirection
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H04L 67/141 - Setup of application sessions
  • H04W 12/50 - Secure pairing of devices
  • H04L 67/53 - Network services using third party service providers
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
  • H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

29.

System and method for authenticating wireless programming system and method for authenticating wireless programming devices in programmable medical systems

      
Application Number 17664411
Grant Number 11871224
Status In Force
Filing Date 2022-05-21
First Publication Date 2022-09-08
Grant Date 2024-01-09
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Rodriguez, Saul
  • Han, Dianna (dan)
  • Istoc, Emil

Abstract

A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.

IPC Classes  ?

  • H04L 29/06 - Communication control; Communication processing characterised by a protocol
  • H04W 12/06 - Authentication
  • H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
  • H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
  • H04L 9/40 - Network security protocols
  • H04L 69/40 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass for recovering from a failure of a protocol instance or entity, e.g. service redundancy protocols, protocol state redundancy or protocol service redirection
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H04L 67/141 - Setup of application sessions
  • H04W 12/50 - Secure pairing of devices
  • H04L 67/53 - Network services using third party service providers
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
  • H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

30.

Single-certificate multi-factor authentication

      
Application Number 17548326
Grant Number 11856113
Status In Force
Filing Date 2021-12-10
First Publication Date 2022-06-16
Grant Date 2023-12-26
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Kohler, Daniel G.

Abstract

A method of multi-factor authentication includes receiving, by a first electronic device, a partial digital certificate including partial certificate information omitting at least one authentication factor from complete certificate information, and a signature encrypting a first hash of the complete certificate information with a certificate authority private key. The method also includes obtaining the first hash by decrypting, by the first electronic device, the signature with a certificate authority public key corresponding to the certificate authority private key; generating, by the first electronic device, a second hash based on the partial certificate information in the partial digital certificate and the at least one authentication factor; and comparing, by the first electronic device, the second hash to the first hash.

IPC Classes  ?

  • H04L 9/40 - Network security protocols
  • H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
  • H04L 9/08 - Key distribution

31.

STIMULATION SYSTEM INCLUDING A MULTI-ELECTRODE EAR SHELL AND METHOD OF USING THE SAME

      
Application Number 17410912
Status Pending
Filing Date 2021-08-24
First Publication Date 2022-05-12
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor Klein, Valma

Abstract

A multi-electrode ear shell includes an inner surface and an outer surface, the inner surface corresponding to a surface of an ear and being configured to overlap a cymba and a cavum of the ear. The multi-electrode ear shell further includes a first socket to receive a first stimulation electrode and a second socket to receive a second stimulation electrode.

IPC Classes  ?

  • A61N 1/04 - Electrodes
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

32.

SENSORS AND METHODS FOR DETERMINING RESPIRATION

      
Application Number 17519263
Status Pending
Filing Date 2021-11-04
First Publication Date 2022-05-05
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Elyahoodayan, Sahar
  • Shelton, Brian M.
  • Talbot, Neal H.

Abstract

The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

33.

AUTOMATICALLY-ALIGNING MAGNETIC FIELD SYSTEM

      
Application Number 17517518
Status Pending
Filing Date 2021-11-02
First Publication Date 2022-05-05
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Dearden, Brian R.
  • Loo, Justin Cheng-Tsu

Abstract

A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.

IPC Classes  ?

  • H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
  • H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
  • H01F 38/14 - Inductive couplings
  • A61N 1/378 - Electrical supply

34.

SENSORS AND METHODS FOR DETERMINING RESPIRATION

      
Application Number 17519211
Status Pending
Filing Date 2021-11-04
First Publication Date 2022-05-05
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Elyahoodayan, Sahar
  • Shelton, Brian M.
  • Talbot, Neal H.

Abstract

The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

35.

ELECTRODE LEADS HAVING MULTI-APPLICATION NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS

      
Application Number 17463611
Status Pending
Filing Date 2021-09-01
First Publication Date 2022-03-03
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Dearden, Brian Ralph
  • Shelton, Brian M.
  • Talbot, Neil

Abstract

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

36.

Acoustic sensing for respiration detection

      
Application Number 17228593
Grant Number 11931578
Status In Force
Filing Date 2021-04-12
First Publication Date 2021-10-14
Grant Date 2024-03-19
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Shelton, Brian M.
  • Elyahoodayan, Sahar
  • Suri, Harshit R.

Abstract

The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 7/00 - Instruments for auscultation
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/378 - Electrical supply

37.

SYSTEMS FOR TREATING OBSTRUCTIVE SLEEP APNEA

      
Application Number 17210033
Status Pending
Filing Date 2021-03-23
First Publication Date 2021-09-23
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Greenberg, Robert J.
  • Suri, Harshit R.
  • Calderon, Joseph L.
  • Dearden, Brian R.

Abstract

Systems for treating obstructive sleep apnea having an implanted stimulator with an internal sensor configured to generate sensory data corresponding to movement of the thoracic or abdominal cavity of a patient during respiration. The system includes a wireless communications link between the stimulator and at least one external sensor for sensing a patient's physiological parameter and is used to augment the sensory data from the internal sensor. The stimulator includes a stimulation system configured to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve to treat sleep apnea.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

38.

NERVE CUFF ELECTRODE LOCKING MECHANISM

      
Application Number 17308350
Status Pending
Filing Date 2021-05-05
First Publication Date 2021-09-02
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Ng, Boon Khai
  • Schmidt, Siegmar

Abstract

A lead comprising a lead body, a lead connector terminal affixed to a proximal end of the lead body, and a cuff body affixed to a distal end of the lead body, an electrode contact affixed to the cuff body, and an electrical conductor between the connector terminal and electrode contact. The lead further comprises a strap extending from a first region of the cuff body, a buckle disposed on a second region of the cuff body, and a locking feature, e.g., protuberance, ring, or wrinkle, associated with the strap. The locking feature is configured for being pulled through the buckle to dispose the cuff body around a nerve in response to a tensile force applied to the strap. The locking feature is configured for abutting an edge of the buckle in response to a release of the tensile force to secure the cuff body around the nerve.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

39.

Stimulator systems and methods for selectively recruiting fascicles in hypoglossal nerve trunk

      
Application Number 17190612
Grant Number 11779759
Status In Force
Filing Date 2021-03-03
First Publication Date 2021-06-24
Grant Date 2023-10-10
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIC RESEARCH (USA)
Inventor
  • Ng, Boon Khai
  • Calderon, Joseph L.

Abstract

An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/378 - Electrical supply
  • A61B 5/394 - Electromyography [EMG] specially adapted for electroglottography or electropalatography

40.

IMPLANTABLE INFUSION DEVICES WITH CLOSED LOOP SENSING AND ASSOCIATED METHODS

      
Application Number 17078816
Status Pending
Filing Date 2020-10-23
First Publication Date 2021-04-29
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Greenberg, Robert J.
  • Suri, Harshit R.
  • Lobl, Thomas J.
  • Shelton, Brian M.
  • Bowman, Sam W.

Abstract

Implantable infusion devices and methods that provide closed loop control.

IPC Classes  ?

  • A61M 5/142 - Pressure infusion, e.g. using pumps

41.

Stimulator systems and methods for obstructive sleep apnea

      
Application Number 17091182
Grant Number 11642529
Status In Force
Filing Date 2020-11-06
First Publication Date 2021-02-25
Grant Date 2023-05-09
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Suri, Harshit
  • Calderon, Joseph L.
  • Molnar, Gregory Frederick
  • Goding, Jr., George S.
  • Atyabi, Alanie
  • Schmidt, Siegmar
  • Dai, William
  • Dearden, Brian
  • Keenan, Desmond B.

Abstract

An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
  • A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
  • A61B 5/087 - Measuring breath flow
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/378 - Electrical supply
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61B 5/394 - Electromyography [EMG] specially adapted for electroglottography or electropalatography

42.

Stimulator systems and methods for obstructive sleep apnea

      
Application Number 17083532
Grant Number 11654284
Status In Force
Filing Date 2020-10-29
First Publication Date 2021-02-11
Grant Date 2023-05-23
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Suri, Harshit
  • Calderon, Joseph L.
  • Molnar, Gregory Frederick
  • Goding, Jr., George S.
  • Atyabi, Alanie
  • Schmidt, Siegmar
  • Dai, William
  • Dearden, Brian
  • Keenan, Desmond B.

Abstract

An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/378 - Electrical supply
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
  • A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
  • A61B 5/087 - Measuring breath flow
  • A61B 5/394 - Electromyography [EMG] specially adapted for electroglottography or electropalatography

43.

Pressure sensors with tensioned membranes

      
Application Number 16941463
Grant Number 11630013
Status In Force
Filing Date 2020-07-28
First Publication Date 2020-11-12
Grant Date 2023-04-18
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schmidt, Siegmar
  • Dai, William A.
  • Ng, Boon Khai

Abstract

Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.

IPC Classes  ?

  • G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
  • G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
  • G01L 7/08 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges of the flexible-diaphragm type
  • G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
  • G01L 19/04 - Means for compensating for effects of changes of temperature
  • G01L 19/16 - Dials; Mounting of dials
  • G01L 19/14 - Housings
  • G01L 19/06 - Means for preventing overload or deleterious influence of the measured medium on the measuring device or vice versa

44.

System and method for authenticating wireless programming devices in programmable medical systems

      
Application Number 16869863
Grant Number 11375370
Status In Force
Filing Date 2020-05-08
First Publication Date 2020-08-20
Grant Date 2022-06-28
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Rodriguez, Saul
  • Han, Dianna (dan)
  • Istoc, Emil

Abstract

A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.

IPC Classes  ?

  • H04L 29/06 - Communication control; Communication processing characterised by a protocol
  • H04W 12/06 - Authentication
  • H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
  • H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
  • H04L 9/40 - Network security protocols
  • H04L 69/40 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass for recovering from a failure of a protocol instance or entity, e.g. service redundancy protocols, protocol state redundancy or protocol service redirection
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H04L 67/141 - Setup of application sessions
  • H04W 12/50 - Secure pairing of devices
  • H04L 67/53 - Network services using third party service providers
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
  • H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

45.

Stimulator systems and methods for obstructive sleep apnea

      
Application Number 16812947
Grant Number 11638826
Status In Force
Filing Date 2020-03-09
First Publication Date 2020-07-02
Grant Date 2023-05-02
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Suri, Harshit
  • Calderon, Joseph L.
  • Molnar, Gregory Frederick
  • Goding, Jr., George S.
  • Atyabi, Alanie
  • Schmidt, Siegmar
  • Dai, William
  • Dearden, Brian
  • Keenan, Desmond B.

Abstract

An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
  • A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
  • A61B 5/087 - Measuring breath flow
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61B 5/394 - Electromyography [EMG] specially adapted for electroglottography or electropalatography
  • A61N 1/378 - Electrical supply

46.

Current sensing multiple output current stimulators

      
Application Number 16792102
Grant Number 11338144
Status In Force
Filing Date 2020-02-14
First Publication Date 2020-06-11
Grant Date 2022-05-24
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H03K 3/012 - Modifications of generator to improve response time or to decrease power consumption
  • H03K 3/023 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of differential amplifiers or comparators, with internal or external positive feedback

47.

Microprocessor controlled class E driver

      
Application Number 16563654
Grant Number 10971950
Status In Force
Filing Date 2019-09-06
First Publication Date 2020-04-02
Grant Date 2021-04-06
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Wolfe, James H.
  • Khemani, Manish

Abstract

A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
  • H03C 3/00 - Angle modulation
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • A61N 1/378 - Electrical supply
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters

48.

Multiple implant communications with adjustable load modulation based on received signal amplitudes

      
Application Number 16580985
Grant Number 10925489
Status In Force
Filing Date 2019-09-24
First Publication Date 2020-01-16
Grant Date 2021-02-23
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Lee, Edward K. F.
  • Suri, Harshit R.

Abstract

A medical system and method of communicating between a telemetry controller and medical devices is provided. Coupling coefficients between a primary coil of the telemetry controller and secondary coils of the medical devices differ from each other. A primary carrier signal is applied to the primary coil, thereby respectively inducing secondary carrier signals on the secondary coils. An amplitude of the secondary carrier signal is measured on each of the secondary coils. The envelope of each secondary carrier signal is modulated in accordance with data, thereby inducing modulation of the envelope of the primary carrier signal for the implanted medical devices. The secondary carrier signal envelopes are modulated based on the measured amplitudes of the respective secondary carrier signals.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H04B 14/00 - Transmission systems not characterised by the medium used for transmission
  • H04L 27/02 - Amplitude-modulated carrier systems, e.g. using on/off keying; Single sideband or vestigial sideband modulation
  • H04L 27/10 - Frequency-modulated carrier systems, i.e. using frequency-shift keying
  • H04L 27/18 - Phase-modulated carrier systems, i.e. using phase-shift keying

49.

Skin patches for sensing or affecting a body parameter

      
Application Number 16362459
Grant Number 11872144
Status In Force
Filing Date 2019-03-22
First Publication Date 2019-09-26
Grant Date 2024-01-16
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Petrovich, John G.

Abstract

Skin patch sensors for monitoring and/or affecting body parameters, with alignment, positioning and attachment using magnets. The repeated use of releasable adhesive layers to retain skin patch sensors on skin can cause skin irritation, which can be reduced by rotating a skin patch between attachment times around a magnetically coupled pivot point. Skin patch sensors can be configured with internal coils to inductively couple to external power transmitting and communications coils with solenoids in anti-Helmholtz configurations.

IPC Classes  ?

  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • B25J 9/00 - Programme-controlled manipulators
  • A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
  • A61F 2/70 - Operating or control means electrical

50.

Nerve cuff electrodes fabricated using over-molded LCP substrates

      
Application Number 16430785
Grant Number 11794003
Status In Force
Filing Date 2019-06-04
First Publication Date 2019-09-19
Grant Date 2023-10-24
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schmidt, Siegmar
  • Ng, Boon Khai

Abstract

An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 5/389 - Electromyography [EMG]

51.

Percutaneous ports with wire coils

      
Application Number 16298950
Grant Number 10940303
Status In Force
Filing Date 2019-03-11
First Publication Date 2019-07-04
Grant Date 2021-03-09
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Jiang, Guangqiang
  • He, Tom

Abstract

The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.

IPC Classes  ?

52.

Stiffness enhanced filaments

      
Application Number 15294578
Grant Number 10335089
Status In Force
Filing Date 2016-10-14
First Publication Date 2019-07-02
Grant Date 2019-07-02
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Schulman, Joseph H.
  • Hankin, David L.

Abstract

Biocompatible stiffness enhanced pliable electrically conductive filaments configured for contact with living tissue and electrical communication with such tissue. The pliability of the filaments allows the distal end of the filaments to remain at the original site of penetration into the tissue despite the movement of the tissue relative to their surrounding environment. To temporarily stiffen the filaments, a soluble stiffness enhancing coating is disposed over the filaments. The coating may be in the form of a liquid which dries to a solid state after being applied to the filaments and renders the filaments sufficiently rigid such that under appropriate force, the filaments are capable of penetrating into dense tissue. Once in place, the stiffness enhancing coating dissolves due to contact with body fluids, the filaments, in the absence of such a coating, return to their initial pliability.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • H05K 5/02 - Casings, cabinets or drawers for electric apparatus - Details
  • A61L 31/02 - Inorganic materials
  • A61L 31/10 - Macromolecular materials
  • A61L 31/14 - Materials characterised by their function or physical properties
  • A61L 31/16 - Biologically active materials, e.g. therapeutic substances

53.

Stimulator systems and methods for selectively recruiting fascicles in hypoglossal nerve trunk

      
Application Number 16118348
Grant Number 10967178
Status In Force
Filing Date 2018-08-30
First Publication Date 2019-02-28
Grant Date 2021-04-06
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Ng, Boon Khai
  • Calderon, Joseph L.

Abstract

An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61B 5/0488 - Electromyography
  • A61N 1/378 - Electrical supply

54.

Current sensing multiple output current stimulators

      
Application Number 15980642
Grant Number 10603495
Status In Force
Filing Date 2018-05-15
First Publication Date 2019-01-17
Grant Date 2020-03-31
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K.F.

Abstract

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H03K 3/012 - Modifications of generator to improve response time or to decrease power consumption
  • H03K 3/023 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of differential amplifiers or comparators, with internal or external positive feedback

55.

Self-expanding nerve cuff electrode

      
Application Number 15967468
Grant Number 10981000
Status In Force
Filing Date 2018-04-30
First Publication Date 2018-11-08
Grant Date 2021-04-20
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Ng, Boon Khai
  • Dai, William

Abstract

An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • A61B 5/0492 - Electrodes specially adapted therefor, e.g. needle electrodes

56.

Multiple implant communications with adjustable load modulation using modulation indices

      
Application Number 15907457
Grant Number 10568513
Status In Force
Filing Date 2018-02-28
First Publication Date 2018-09-13
Grant Date 2020-02-25
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Lee, Edward K. F.
  • Suri, Harshit R.

Abstract

A medical system and method of communicating between a telemetry controller and a plurality of medical devices implanted within a patient is provided. Communication links are respectively established between the telemetry controller and the implanted medical devices. The communication links are respectively amplitude modulated by the implanted medical devices at modulation levels using load modulation. Received signal strength indicators (RSSIs) of the amplitude modulated communication links for the implanted medical devices are measured. A variation of the RSSIs is decreased by modifying, based on the measured RSSIs, at least one modulation level at which the respective at least one communication link is amplitude modulated by the respective implanted medical device(s).

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
  • H04B 17/318 - Received signal strength
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • A61B 5/0488 - Electromyography
  • A61F 2/58 - Elbows; Wrists
  • A61F 2/70 - Operating or control means electrical

57.

Multiple implant communications with adjustable load modulation based on received signal amplitudes

      
Application Number 15890509
Grant Number 10537246
Status In Force
Filing Date 2018-02-07
First Publication Date 2018-08-09
Grant Date 2020-01-21
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Lee, Edward K. F.
  • Suri, Harshit R.

Abstract

A medical system and method of communicating between a telemetry controller and medical devices is provided. Coupling coefficients between a primary coil of the telemetry controller and secondary coils of the medical devices differ from each other. A primary carrier signal is applied to the primary coil, thereby respectively inducing secondary carrier signals on the secondary coils. An amplitude of the secondary carrier signal is measured on each of the secondary coils. The envelope of each secondary carrier signal is modulated in accordance with data, thereby inducing modulation of the envelope of the primary carrier signal for the implanted medical devices. The secondary carrier signal envelopes are modulated based on the measured amplitudes of the respective secondary carrier signals.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H04B 14/00 - Transmission systems not characterised by the medium used for transmission

58.

Rectifier and regulator circuit

      
Application Number 15255010
Grant Number 10033296
Status In Force
Filing Date 2016-09-01
First Publication Date 2018-07-24
Grant Date 2018-07-24
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor Lee, Edward K. F.

Abstract

Systems and methods for rectifying and regulating an input voltage are disclosed. A biasing circuit is configured to generate a biasing voltage greater than the maximum value of the input voltage minus a forward bias voltage of a p-n junction diode and apply the biasing voltage to the body terminal of a MOSFET. The biasing circuit may generate the biasing voltage by rectifying the input voltage. A control circuit is configured to generate a gate voltage based on the rectified and regulated output voltage and apply the gate voltage to the gate terminal of the MOSFET.

IPC Classes  ?

  • H02M 3/155 - Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
  • H02M 7/217 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
  • H02M 1/32 - Means for protecting converters other than by automatic disconnection

59.

Neurostimulators and stimulation systems

      
Application Number 15851646
Grant Number 10639480
Status In Force
Filing Date 2017-12-21
First Publication Date 2018-06-28
Grant Date 2020-05-05
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Suri, Harshit
  • Lee, Edward K. F.

Abstract

In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/02 - Electrotherapy; Circuits therefor - Details
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

60.

High efficiency magnetic link for implantable devices

      
Application Number 15817997
Grant Number 10449377
Status In Force
Filing Date 2017-11-20
First Publication Date 2018-05-17
Grant Date 2019-10-22
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Griffith, Glen A.

Abstract

Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • A61N 1/378 - Electrical supply
  • H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H02J 17/00 - Systems for supplying or distributing electric power by electromagnetic waves
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters

61.

Apparatus for heating gas

      
Application Number 15673332
Grant Number 10739088
Status In Force
Filing Date 2017-08-09
First Publication Date 2018-02-15
Grant Date 2020-08-11
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Norlin, Petrus

Abstract

An apparatus for heating gas utilizes a series of chambers through which a gas volume is advanced, and a gradational heat transfer element which enables incremental heat transfer to the gas volume as the gas volume is advanced through the chambers.

IPC Classes  ?

  • F24F 13/06 - Outlets for directing or distributing air into rooms or spaces, e.g. ceiling air diffuser
  • F28F 13/06 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media
  • F24H 3/00 - Air heaters
  • F28F 13/10 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by imparting a pulsating motion to the flow, e.g. by sonic vibration
  • F28F 7/00 - Elements not covered by group , , or
  • F28D 20/00 - Heat storage plants or apparatus in general; Regenerative heat-exchange apparatus not covered by groups or
  • F28F 13/00 - Arrangements for modifying heat transfer, e.g. increasing, decreasing

62.

Implantable shunt system and associated pressure sensors

      
Application Number 15641174
Grant Number 10687719
Status In Force
Filing Date 2017-07-03
First Publication Date 2017-12-14
Grant Date 2020-06-23
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Schmidt, Siegmar
  • Byers, Charles L.
  • Jiang, Guangqiang
  • Dearden, Brian R.
  • Gord, John C.
  • Rodriguez, Daniel

Abstract

A hermetically sealed biocompatible pressure sensor module configured for implant at a desired site at which a pressure is to be measured. Anodic bonding of the pressure module package components which have similar thermal coefficients of expansion provides low stress bonding and maintains long term reliability, dependability and accuracy. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. Operating power for the pressure sensor module is provided by the external controller and an internal rechargeable energy storage component. Accordingly, the pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system. An exemplary use of the pressure sensor module is in a three pressure sensor system including a flow control valve in a shunt to treat hydrocephalus. The use of integrated circuit chips and an internal coil with an optional ferrite core in the pressure sensor module provides for low power consumption and reliable signal processing. An embodiment of the invention includes a pressure sensor and associated electromagnetic coils embedded in the tip portion of the shunt for measuring the pressure of fluid externally of the shunt at the tip portion.

IPC Classes  ?

  • A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
  • A61B 5/07 - Endoradiosondes
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • A61M 27/00 - Drainage appliances for wounds, or the like
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
  • A61N 1/378 - Electrical supply
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

63.

Microprocessor controlled class E driver

      
Application Number 15685874
Grant Number 10447083
Status In Force
Filing Date 2017-08-24
First Publication Date 2017-12-07
Grant Date 2019-10-15
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Wolfe, James H.
  • Khemani, Manish

Abstract

A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
  • H03C 3/00 - Angle modulation
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • A61N 1/378 - Electrical supply
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices

64.

Pressure sensors with tensioned membranes

      
Application Number 15485190
Grant Number 10739218
Status In Force
Filing Date 2017-04-11
First Publication Date 2017-10-12
Grant Date 2020-08-11
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schmidt, Siegmar
  • Dai, William A.
  • Ng, Boon Khai

Abstract

Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.

IPC Classes  ?

  • G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
  • G01L 7/08 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges of the flexible-diaphragm type
  • G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
  • G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
  • G01L 19/14 - Housings
  • G01L 19/04 - Means for compensating for effects of changes of temperature
  • G01L 19/06 - Means for preventing overload or deleterious influence of the measured medium on the measuring device or vice versa

65.

System and method for authenticating wireless programming devices in programmable medical systems

      
Application Number 15452339
Grant Number 10652740
Status In Force
Filing Date 2017-03-07
First Publication Date 2017-09-07
Grant Date 2020-05-12
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Rodriguez, Saul
  • Han, Dianna (dan)
  • Istoc, Emil

Abstract

A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.

IPC Classes  ?

  • H04L 29/06 - Communication control; Communication processing characterised by a protocol
  • H04W 12/06 - Authentication
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
  • H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
  • H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
  • H04L 29/14 - Counter-measures to a fault
  • H04W 12/00 - Security arrangements; Authentication; Protecting privacy or anonymity
  • A61B 5/0488 - Electromyography
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

66.

Brain implant device

      
Application Number 14476682
Grant Number 09622677
Status In Force
Filing Date 2014-09-03
First Publication Date 2017-04-18
Grant Date 2017-04-18
Owner Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Stover, Howard H.
  • Gord, John C.
  • Byers, Charles L.
  • Schulman, Joseph H.
  • Jiang, Guangqiang
  • Davis, Ross

Abstract

A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.

IPC Classes  ?

  • A61B 5/0478 - Electrodes specially adapted therefor
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof

67.

Active rectifier and regulator circuit

      
Application Number 14491845
Grant Number 09608537
Status In Force
Filing Date 2014-09-19
First Publication Date 2017-03-28
Grant Date 2017-03-28
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

The various embodiments described herein include systems, methods and/or devices used to produce a rectified and regulated output signal. In one aspect, the method includes, at a circuit, comparing an output signal at an output node with an input signal at an input node, wherein the output signal is a rectified and regulated signal, and the input signal is an unrectified and unregulated signal, and computing a difference between a reference signal and a comparison signal. Power transfer from the input node to the output node is prevented when the output signal is greater than the input signal. Furthermore, power transfer from the input node to the output node is regulated to produce the rectified and regulated output signal when both the input signal is greater than the output signal, and when the magnitude of the reference signal exceeds the magnitude of the comparison signal.

IPC Classes  ?

  • H02M 7/217 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
  • H02J 5/00 - Circuit arrangements for transfer of electric power between ac networks and dc networks

68.

Current sensing multiple output current stimulators

      
Application Number 15263046
Grant Number 09981130
Status In Force
Filing Date 2016-09-12
First Publication Date 2016-12-29
Grant Date 2018-05-29
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

IPC Classes  ?

  • A61N 1/00 - Electrotherapy; Circuits therefor
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H03K 3/012 - Modifications of generator to improve response time or to decrease power consumption
  • H03K 3/023 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of differential amplifiers or comparators, with internal or external positive feedback

69.

Multi-branch stimulation electrode for subcutaneous field stimulation

      
Application Number 15232632
Grant Number 10029090
Status In Force
Filing Date 2016-08-09
First Publication Date 2016-12-01
Grant Date 2018-07-24
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Shelton, Brian M.
  • Hansen, Morten

Abstract

A multi-branch stimulation electrode is disclosed herein. The multi-branch stimulation electrode can include a plurality of branches that extend from a hub. The branches can each include one or several stimulation contacts that can deliver an electrical current to tissue contacting the stimulation contacts. The stimulation contacts can be electrically connected with the lead. The lead can extend from the hub and can be connected with the pulse generator. The branches can include features to facilitate implantation including, for example, one or several removable stiffening elements.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

70.

Method for providing stiffness enhanced filaments

      
Application Number 13863271
Grant Number 09480410
Status In Force
Filing Date 2013-04-15
First Publication Date 2016-11-01
Grant Date 2016-11-01
Owner THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Schulman, Joseph H.
  • Hankin, David L.

Abstract

Methods for making biocompatible stiffness enhanced pliable electrically conductive filaments configured for contact with living tissue and electrical communication with such tissue. The pliability of a filament allows the distal end of the filament to remain at the original site of penetration into the tissue despite the movement of the tissue relative to its surrounding environment. To temporarily stiffen the filament, a soluble stiffness enhancing coating is disposed over the filament. The coating may be in the form of a liquid which dries to a solid state after being applied to the filament and renders the filament sufficiently rigid such that under appropriate force, the filament is capable of penetrating into dense tissue. Once in place the stiffness enhancing coating dissolves due to contact with body fluids, the filament, in the absence of such coating, returns to its initial pliability.

IPC Classes  ?

  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

71.

Implant recharger handshaking system and method

      
Application Number 15055326
Grant Number 09789325
Status In Force
Filing Date 2016-02-26
First Publication Date 2016-09-01
Grant Date 2017-10-17
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Shelton, Brian M.
  • Dearden, Brian R.
  • Wolfe, James H.

Abstract

Systems, methods, and devices for wireless recharging of an implanted device. In response to receiving identification information from an implanted device, a charger can set an electrical field to a first field strength and receive first field strength information from the implanted device. The charger can then set the electrical field to a second field strength and receive second field strength information from the implanted device. This information relating to the first and second field strengths can be used to determine whether to recharge the implanted device.

IPC Classes  ?

72.

Inductive link coil de-tuning compensation and control

      
Application Number 15015112
Grant Number 10512553
Status In Force
Filing Date 2016-02-03
First Publication Date 2016-08-04
Grant Date 2019-12-24
Owner The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor Griffith, Glen A.

Abstract

An inductive wireless power transfer and communication system includes an electrostatic shield for one of the coils. The electrostatic shield is inductively coupled with the coil and is configured as an open circuit. A signal processing element or elements, especially a modulator or a demodulator, are connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the modulator or demodulator can operate on the signal on the coil. A variable impedance element is connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the variable impedance element can tune the impedance of the system.

IPC Classes  ?

  • H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
  • A61F 2/54 - Artificial arms or hands or parts thereof
  • H01F 38/14 - Inductive couplings
  • A61F 2/70 - Operating or control means electrical
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/378 - Electrical supply

73.

Methods and systems for applying charge to a piezoelectric element

      
Application Number 15009591
Grant Number 09806249
Status In Force
Filing Date 2016-01-28
First Publication Date 2016-05-26
Grant Date 2017-10-31
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Renger, Herman Lee
  • Bowman, Sam William

Abstract

Methods and systems for applying charge to a piezoelectric element include and/or facilitate implementation of processes including cyclical multi-stage processes for: providing a piezoelectric element with an accumulated charge; providing one or more charge holding elements with a scavenged charge from the piezoelectric element; substantially removing or discharging a remaining charge from the piezoelectric element; and applying the scavenged charge to the piezoelectric element with an opposite polarity in relation to the polarity of the remaining charge.

IPC Classes  ?

  • H01L 41/04 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof - Details of piezo-electric or electrostrictive elements
  • H02N 2/06 - Drive circuits; Control arrangements
  • F04B 43/04 - Pumps having electric drive
  • F04B 39/00 - Component parts, details, or accessories, of pumps or pumping systems specially adapted for elastic fluids, not otherwise provided for in, or of interest apart from, groups
  • F04B 43/09 - Pumps having electric drive

74.

EPG leaded interface

      
Application Number 14940090
Grant Number 09724523
Status In Force
Filing Date 2015-11-12
First Publication Date 2016-05-19
Grant Date 2017-08-08
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Calderon, Joseph L.
  • Hillery, Edward
  • Lockhart, Joseph

Abstract

An interface for coupling with a percutaneously implantable lead is described. The interface includes a rotation based system to engage the terminal connector of the lead. The interface includes a brake which retains the lead in the lead port through friction, but allows the lead to exit the lead port if sufficient force is applied. The interface can be coupled with the lead without removing a stylet or stiffening wire from the lead.

IPC Classes  ?

  • H01R 39/00 - Rotary current collectors, distributors or interrupters
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

75.

High reliability wire welding for implantable devices

      
Application Number 14936613
Grant Number 09675807
Status In Force
Filing Date 2015-11-09
First Publication Date 2016-05-12
Grant Date 2017-06-13
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Schmidt, Siegmar

Abstract

Methods of making an implantable pulse generator are disclosed herein. The implantable pulse generator can include a body defining an internal volume and a plurality of wires extending from out of the internal volume of the body. Some of these wires can be connected, either directly or indirectly to a lead via a welded joint. The welded joint can be created by first resistance welding and then laser welding some of the wires to a connector.

IPC Classes  ?

  • A61N 1/00 - Electrotherapy; Circuits therefor
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • B23K 26/22 - Spot welding
  • B23K 11/00 - Resistance welding; Severing by resistance heating
  • B23K 11/11 - Spot welding
  • B23K 28/02 - Combined welding or cutting procedures or apparatus
  • H01R 43/02 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for soldered or welded connections
  • H01R 43/033 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for wrapping or unwrapping wire connections
  • B23K 101/32 - Wires

76.

Percutaneous ports with wire coils

      
Application Number 14877865
Grant Number 10226612
Status In Force
Filing Date 2015-10-07
First Publication Date 2016-04-14
Grant Date 2019-03-12
Owner Alfred E. Mann Foundation For Scientific Research (USA)
Inventor
  • Jiang, Guangqiang
  • He, Tom

Abstract

The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.

IPC Classes  ?

77.

Method of manufacturing percutaneous ports with wire coils

      
Application Number 14877857
Grant Number 10086184
Status In Force
Filing Date 2015-10-07
First Publication Date 2016-04-14
Grant Date 2018-10-02
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Jiang, Guangqiang
  • He, Tom

Abstract

The various implementations described herein include methods used to manufacture a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the method includes providing a tubular structure having an outer surface and providing a coil having an outer surface and comprised of a plurality of loops. The method further includes joining at least a portion of the outer surface of the coil to the outer surface of the tubular structure.

IPC Classes  ?

  • A61M 39/02 - Access sites
  • B21F 3/04 - Coiling wire into particular forms helically externally on a mandrel or the like
  • B21F 15/00 - Connecting wire to wire or other metallic material or objects; Connecting parts by means of wire
  • B23K 1/00 - Soldering, e.g. brazing, or unsoldering
  • C23F 1/14 - Aqueous compositions

78.

Wireless power transfer and communications

      
Application Number 14814447
Grant Number 09962085
Status In Force
Filing Date 2015-07-30
First Publication Date 2016-02-04
Grant Date 2018-05-08
Owner The Alfred E. Mann Foundation For Scientific Research (USA)
Inventor Griffith, Glen A.

Abstract

An inductive wireless power transfer and communication system includes an electrostatic shield for one of the coils. The electrostatic shield is inductively coupled with the coil and is configured as an open circuit. A signal processing element or elements, especially a modulator or a demodulator, are connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the modulator or demodulator can operate on the signal on the coil.

IPC Classes  ?

  • H01F 37/00 - Fixed inductances not covered by group
  • A61F 2/54 - Artificial arms or hands or parts thereof
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
  • H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
  • H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/378 - Electrical supply
  • A61F 2/70 - Operating or control means electrical
  • A61F 2/76 - Means for assembling, fitting, or testing prostheses, e.g. for measuring or balancing

79.

Microfluidic flow rate sensor

      
Application Number 14774921
Grant Number 09714853
Status In Force
Filing Date 2014-03-14
First Publication Date 2016-01-28
Grant Date 2017-07-25
Owner Alfred E. Mann Foundation For Scientific Research (USA)
Inventor
  • Byers, Charles L.
  • Hetlinger, Chris J.

Abstract

A microfluidic flow rate sensor includes a droplet within a channel and a droplet movement detector that generates a signal based on the position and/or movement of the droplet within the channel. A processor determines the flow rate of a fluid through the channel based on the signal received from the droplet movement detector. In one example, the droplet movement detector is an optical detector, such as a combination of a lens and an image capturing device. In other examples, the droplet is electrically conductive, and at least a portion of the channel is conductive or includes electrical contacts. The position of the droplet within the channel is determined by observing the electrical characteristics of the channel.

IPC Classes  ?

  • G01F 1/56 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects
  • G01F 1/708 - Measuring the time taken to traverse a fixed distance

80.

High voltage monitoring successive approximation analog to digital converter

      
Application Number 14693740
Grant Number 09682237
Status In Force
Filing Date 2015-04-22
First Publication Date 2015-12-31
Grant Date 2017-06-20
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A successive approximation ADC made of a low voltage configurable differential amplifier and low voltage logic circuits which can convert a high voltage analog input to a digital equivalent. The differential amplifier can be configured as either an op amp or a comparator depending upon the mode of operation. An input capacitor C1 is switchably coupled to an electrode selected for voltage sampling. A switched capacitor array C2 is coupled across the differential amplifier input and output. A SAR coupled to the switched capacitor array provides a digital output corresponding to the sampled analog voltage. During a sampling interval and a charge transfer interval, the differential amplifier is configured as an op amp. During the transfer interval, the voltage on the input capacitor multiplied by the ratio C1/C2 is transferred to the switched capacitor array. During an analog to digital conversion interval, the ADC converts the analog voltage to an equivalent digital output.

IPC Classes  ?

  • H03M 1/12 - Analogue/digital converters
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H03M 1/38 - Analogue value compared with reference values sequentially only, e.g. successive approximation type
  • H03M 1/80 - Simultaneous conversion using weighted impedances
  • H03M 1/00 - Analogue/digital conversion; Digital/analogue conversion
  • H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter
  • H03M 1/68 - Digital/analogue converters with conversions of different sensitivity, i.e. one conversion relating to the more significant digital bits and another conversion to the less significant bits

81.

Class E coil driver with switched capacitor ASK modulation

      
Application Number 14698729
Grant Number 09837831
Status In Force
Filing Date 2015-04-28
First Publication Date 2015-11-05
Grant Date 2017-12-05
Owner The Alfred E. Mann Foundation For Scientific Research (USA)
Inventor Lee, Edward K. F.

Abstract

A feedback controlled coil driver with ASK modulation is disclosed. A class E coil driver drives an LC circuit to generate a magnetic signal via the inductor. A modulation capacitor is coupled to the LC circuit to modulate the coil driver signal. The voltage across the coil driver switch is sampled. The difference between the sampled voltage and a reference voltage is integrated and compared to a ramp voltage to obtain an optimal on time for the coil driver switch such that coil current is maximized.

IPC Classes  ?

  • H01F 27/42 - Circuits specially adapted for the purpose of modifying, or compensating for, electric characteristics of transformers, reactors or choke coils
  • H01F 37/00 - Fixed inductances not covered by group
  • H01F 38/00 - Adaptations of transformers or inductances for specific applications or functions
  • H02J 5/00 - Circuit arrangements for transfer of electric power between ac networks and dc networks
  • H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
  • H02J 17/00 - Systems for supplying or distributing electric power by electromagnetic waves
  • H01F 38/14 - Inductive couplings

82.

Electrode implant device

      
Application Number 12555774
Grant Number 09101753
Status In Force
Filing Date 2009-09-08
First Publication Date 2015-08-11
Grant Date 2015-08-11
Owner Alfred E. Mann Foundation For Scientific Research (USA)
Inventor
  • Calderon, Joseph L.
  • Davis, Ross
  • Mishler, Delta

Abstract

The invention is a hollow electrode implantation device for inserting a flexible electrode, such as a Memberg electrode, in living tissue. The inserter has a longitudinal slot that accepts the electrode into the hollow center of the electrode implantation device. The slot is offset at least once forming one or more offset slots, where retainer tabs define the slots and assure retention of the electrode in the implantation device during insertion of the electrode into living tissue.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61B 17/34 - Trocars; Puncturing needles

83.

Feedback controlled coil driver for inductive power transfer

      
Application Number 14631627
Grant Number 09728981
Status In Force
Filing Date 2015-02-25
First Publication Date 2015-06-18
Grant Date 2017-08-08
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A fully integrated feedback controlled coil driver is disclosed for inductive power transfer to electronic devices. For efficient power transfer, a voltage across a switch that switchably couples the coil between a DC input power source and ground is sampled and compared with a preselected reference voltage to generate an error voltage. The error voltage is integrated over time and compared to a voltage ramp. The value of the integrated error voltage relative to the voltage ramp is used to obtain an optimal on time for the switch such that coil current is maximized for a given DC input power. The coil driver can also provide ASK modulation on the coil current by changing the size of the switch according to input data.

IPC Classes  ?

  • H01F 27/42 - Circuits specially adapted for the purpose of modifying, or compensating for, electric characteristics of transformers, reactors or choke coils
  • H01F 37/00 - Fixed inductances not covered by group
  • H01F 38/00 - Adaptations of transformers or inductances for specific applications or functions
  • H02J 5/00 - Circuit arrangements for transfer of electric power between ac networks and dc networks
  • H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
  • H01F 38/14 - Inductive couplings

84.

High voltage rectifier and voltage doubler using low voltage CMOS process transistors

      
Application Number 13917426
Grant Number 09042144
Status In Force
Filing Date 2013-06-13
First Publication Date 2015-05-26
Grant Date 2015-05-26
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A high voltage full wave rectifier and doubler circuit having complementary serially connected low voltage MOSFET stacks to provide high voltage capability. The state of the MOSFETs in the MOSFET stacks is controlled by means of resistors coupled between the circuit's outputs and a time varying input signal. The resistance values of the resistors are selected to maintain operation of the stacked MOSFETs below their breakdown voltages.

IPC Classes  ?

  • H02M 7/217 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
  • H02M 5/42 - Conversion of ac power input into ac power output, e.g. for change of voltage, for change of frequency, for change of number of phases with intermediate conversion into dc by static converters
  • H02M 7/06 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes without control electrode or semiconductor devices without control electrode

85.

Implant charging field control through radio link

      
Application Number 14593807
Grant Number 09155901
Status In Force
Filing Date 2015-01-09
First Publication Date 2015-05-21
Grant Date 2015-10-13
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Shelton, Brian M.
  • Wolfe, James H.

Abstract

A charger that evaluates the effectiveness of the charging field generated by the charger at an implantable device. The charger includes a charging coil, a communication module, and a processor. The processor can include instructions to determine the effectiveness of the charging field based on one or several signals or communications received from the implantable device. The charger can use the determination of the effectiveness of the charging field to vary the strength of the charging field and/or to prompt the user to move the charger with respect to the implantable device.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • A61N 1/378 - Electrical supply
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • H02J 5/00 - Circuit arrangements for transfer of electric power between ac networks and dc networks
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • G01R 19/12 - Measuring rate of change
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators

86.

Timing controlled AC to DC converter and method

      
Application Number 14599779
Grant Number 09715243
Status In Force
Filing Date 2015-01-19
First Publication Date 2015-05-14
Grant Date 2017-07-25
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A timing controlled converter and method for converting a time varying input signal to a regulated DC output voltage for application to a load circuit. A feedback loop is employed as a control means for switchably coupling the time varying input signal to the load circuit for controlled periods of time in a manner so as to provide an average load voltage equal to a reference voltage. The duration of the controlled periods of time is a function of: the difference between the time varying input signal and the output voltage; and the integral of the difference between the output voltage and the reference voltage.

IPC Classes  ?

  • H02M 7/217 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
  • G05F 1/56 - Regulating voltage or current wherein the variable actually regulated by the final control device is dc using semiconductor devices in series with the load as final control devices
  • G05F 1/59 - Regulating voltage or current wherein the variable actually regulated by the final control device is dc using semiconductor devices in series with the load as final control devices including plural semiconductor devices as final control devices for a single load
  • H02M 3/158 - Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
  • H02M 7/219 - Conversion of ac power input into dc power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only in a bridge configuration

87.

Microprocessor controlled class E driver

      
Application Number 14593781
Grant Number 09166441
Status In Force
Filing Date 2015-01-09
First Publication Date 2015-05-07
Grant Date 2015-10-20
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Wolfe, James H.
  • Khemani, Manish

Abstract

A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • H03C 3/00 - Angle modulation
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • A61N 1/378 - Electrical supply
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

88.

High efficiency magnetic link for implantable devices

      
Application Number 14593795
Grant Number 09205273
Status In Force
Filing Date 2015-01-09
First Publication Date 2015-05-07
Grant Date 2015-12-08
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Griffith, Glen A.

Abstract

Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • A61N 1/378 - Electrical supply
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

89.

Method of manufacture of an electrode array

      
Application Number 13211233
Grant Number 08991680
Status In Force
Filing Date 2011-08-16
First Publication Date 2015-03-31
Grant Date 2015-03-31
Owner Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Schulman, Joseph H.
  • Jiang, Guangqiang
  • Byers, Charles L.

Abstract

The electrode array is a device for making electrical contacts with cellular tissue or organs. The electrode array includes an assembly of electrically conductive electrodes arising from a substrate where the electrodes are hermetically bonded to the substrate. A method of manufacture of an electrode array and associated circuitry is disclosed where the braze preform tab disappears during the braze bonding process and is completely drawn into the substrate feedthrough holes such that the braze perform tab is completely involved in the braze joint and is no longer connecting the adjacent electrodes.

IPC Classes  ?

  • B23K 31/02 - Processes relevant to this subclass, specially adapted for particular articles or purposes, but not covered by any single one of main groups relating to soldering or welding
  • B23K 1/19 - Soldering, e.g. brazing, or unsoldering taking account of the properties of the materials to be soldered

90.

High efficiency magnetic link for implantable devices

      
Application Number 14446291
Grant Number 09855436
Status In Force
Filing Date 2014-07-29
First Publication Date 2015-01-29
Grant Date 2018-01-02
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Griffith, Glen A.

Abstract

Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel.

IPC Classes  ?

  • A61N 1/378 - Electrical supply
  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H02J 17/00 - Systems for supplying or distributing electric power by electromagnetic waves

91.

Microprocessor controlled class E driver

      
Application Number 14446294
Grant Number 09780596
Status In Force
Filing Date 2014-07-29
First Publication Date 2015-01-29
Grant Date 2017-10-03
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Dearden, Brian R.
  • Wolfe, James H.
  • Khemani, Manish

Abstract

A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.

IPC Classes  ?

  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
  • H03C 3/00 - Angle modulation
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • A61N 1/378 - Electrical supply
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

92.

High reliability wire welding for implantable devices

      
Application Number 14270115
Grant Number 09221119
Status In Force
Filing Date 2014-05-05
First Publication Date 2014-11-27
Grant Date 2015-12-29
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Schmidt, Siegmar

Abstract

Methods of making an implantable pulse generator are disclosed herein. The implantable pulse generator can include a body defining an internal volume and a plurality of wires extending from out of the internal volume of the body. Some of these wires can be connected, either directly or indirectly to a lead via a welded joint. The welded joint can be created by first resistance welding and then laser welding some of the wires to a connector.

IPC Classes  ?

93.

Multi-branch stimulation electrode for subcutaneous field stimulation

      
Application Number 14270075
Grant Number 09433779
Status In Force
Filing Date 2014-05-05
First Publication Date 2014-11-06
Grant Date 2016-09-06
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Shelton, Brian M.
  • Hansen, Morten

Abstract

A multi-branch stimulation electrode is disclosed herein. The multi-branch stimulation electrode can include a plurality of branches that extend from a hub. The branches can each include one or several stimulation contacts that can deliver an electrical current to tissue contacting the stimulation contacts. The stimulation contacts can be electrically connected with the lead. The lead can extend from the hub and can be connected with the pulse generator. The branches can include features to facilitate implantation including, for example, one or several removable stiffening elements.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/375 - Constructional arrangements, e.g. casings
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

94.

Implant recharger handshaking system and method

      
Application Number 14270092
Grant Number 09308378
Status In Force
Filing Date 2014-05-05
First Publication Date 2014-11-06
Grant Date 2016-04-12
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
  • Shelton, Brian M.
  • Dearden, Brian R.
  • Wolfe, James H.

Abstract

Systems, methods, and devices for wireless recharging of an implanted device. In response to receiving identification information from an implanted device, a charger can set an electrical field to a first field strength and receive first field strength information from the implanted device. The charger can then set the electrical field to a second field strength and receive second field strength information from the implanted device. This information relating to the first and second field strengths can be used to determine whether to recharge the implanted device.

IPC Classes  ?

95.

Brain implant device

      
Application Number 11983674
Grant Number 08862235
Status In Force
Filing Date 2007-11-09
First Publication Date 2014-10-14
Grant Date 2014-10-14
Owner Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Stover, Howard H.
  • Gord, John C.
  • Byers, Charles L.
  • Schulman, Joseph H.
  • Jiang, Guangqiang
  • Davis, Ross

Abstract

A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.

IPC Classes  ?

  • A61N 1/00 - Electrotherapy; Circuits therefor
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

96.

Surgical dilators with tips having curved tapers

      
Application Number 14174790
Grant Number 09623219
Status In Force
Filing Date 2014-02-06
First Publication Date 2014-09-18
Grant Date 2017-04-18
Owner The Alfred E. Mann Foundation For Scientific Research (USA)
Inventor Calderon, Joseph L.

Abstract

Surgical dilators with tips having curved tapers and with a minimal distance between the distal and proximal ends of the dilator tips provide for precision placement of miniature medical devices at a target area in a body with reduced insertion force. A contour of a longitudinal cross section of the dilator tip comprises a first convex portion extending from the distal end to a first interface; a concave portion extending from the first interface to a second interface; and a second convex portion extending from the second interface to a third interface at the proximal end. The first convex portion and the second convex portion are convex relative to an interior of the tip and the concave portion is concave relative to the interior of the tip.

IPC Classes  ?

  • A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
  • A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
  • A61B 17/34 - Trocars; Puncturing needles

97.

Suture tracking dilators and related methods

      
Application Number 14207404
Grant Number 09623220
Status In Force
Filing Date 2014-03-12
First Publication Date 2014-09-18
Grant Date 2017-04-18
Owner The Alfred E. Mann Foundation For Scientific Research (USA)
Inventor
  • Perrin, Michael R.
  • Ripley, Kenneth L.
  • Calderon, Joseph L.

Abstract

Suture tracking dilators and methods for removing implanted medical devices such as microstimulators or microsensors from living tissue are described. A suture tracking dilator has a slit running along its axial length. The slit can have a curved portion. A suture is attached to a medical device prior to its implantation. To remove the implanted medical device, the free end of the suture is exposed and inserted in the slit in the suture tracking dilator. The suture is held under tension at its free end, the dilator is inserted in the living tissue and the dilator follows the suture to the implanted medical device. The medical device is removed by pulling on the free end of the suture.

IPC Classes  ?

  • A61B 17/32 - Surgical cutting instruments
  • A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
  • A61B 17/3209 - Incision instruments
  • A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
  • A61B 17/34 - Trocars; Puncturing needles
  • A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

98.

Current sensing multiple output current stimulators

      
Application Number 14217321
Grant Number 09446241
Status In Force
Filing Date 2014-03-17
First Publication Date 2014-09-18
Grant Date 2016-09-20
Owner ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor Lee, Edward K. F.

Abstract

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

IPC Classes  ?

  • A61N 1/00 - Electrotherapy; Circuits therefor
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • H03K 3/012 - Modifications of generator to improve response time or to decrease power consumption

99.

High voltage monitoring successive approximation analog to digital converter

      
Application Number 14217329
Grant Number 09044614
Status In Force
Filing Date 2014-03-17
First Publication Date 2014-09-18
Grant Date 2015-06-02
Owner Alfred E. Mann Foundation for Scientific Research (USA)
Inventor Lee, Edward K. F.

Abstract

A successive approximation ADC made of a low voltage configurable differential amplifier and low voltage logic circuits which can convert a high voltage analog input to a digital equivalent. The differential amplifier can be configured as either an op amp or a comparator depending upon the mode of operation. An input capacitor C1 is switchably coupled to an electrode selected for voltage sampling. A switched capacitor array C2 is coupled across the differential amplifier input and output. A SAR coupled to the switched capacitor array provides a digital output corresponding to the sampled analog voltage. During a sampling interval and a charge transfer interval, the differential amplifier is configured as an op amp. During the transfer interval, the voltage on the input capacitor multiplied by the ratio C1/C2 is transferred to the switched capacitor array. During an analog to digital conversion interval, the ADC converts the analog voltage to an equivalent digital output.

IPC Classes  ?

  • H03M 1/12 - Analogue/digital converters
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/372 - Arrangements in connection with the implantation of stimulators
  • H03M 1/80 - Simultaneous conversion using weighted impedances
  • H03M 1/00 - Analogue/digital conversion; Digital/analogue conversion
  • H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter
  • H03M 1/68 - Digital/analogue converters with conversions of different sensitivity, i.e. one conversion relating to the more significant digital bits and another conversion to the less significant bits

100.

Implantable shunt system and associated pressure sensors

      
Application Number 13984826
Grant Number 09713429
Status In Force
Filing Date 2012-02-16
First Publication Date 2014-08-28
Grant Date 2017-07-25
Owner Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
  • Schmidt, Siegmar
  • Byers, Charles L.
  • Jiang, Guangqiang
  • Dearden, Brian R.
  • Gord, John C.
  • Rodriguez, Daniel

Abstract

A pressure sensor module configured for implant at a desired site at which a pressure is to be measured. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. The pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system. An exemplary use is in a three pressure sensor system including a flow control valve in a shunt to treat hydrocephalus. An embodiment of the invention includes a pressure sensor and associated electromagnetic coils embedded in the tip portion of the shunt for measuring the pressure of fluid externally of the shunt at the tip portion.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
  • A61B 5/07 - Endoradiosondes
  • A61M 27/00 - Drainage appliances for wounds, or the like
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