The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Trivedi, Hemang
Brandt, William Andrew
Elyahoodayan, Sahar
Jenney, Christopher Reed
Abstract
An electrode lead includes an elongate lead body and a nerve cuff. The nerve cuff may include a cuff body, with a front layer and a rear layer, affixed to the distal end of the lead body and a plurality of electrically conductive members located between the front and rear layers. Each of the electrically conductive member defines a front side, a rear side and an outer perimeter and may include a plurality of holes that extend from the front side to the rear side and that are located around the outer perimeter. The cuff body front layer includes a plurality of windows that are respectively aligned with and located inwardly of the outer perimeters of the electrically conductive members, and a plurality of window frames that extend from the windows to the outer perimeters of the electrically conductive members. The cuff body also includes a plurality of anchors that respectively extend through the electrically conductive member holes and connect the window frames to the cuff body rear layer.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Trivedi, Hemang
Brandt, William, Andrew
Elyahoodayan, Sahar
Jenney, Christopher, Reed
Abstract
An electrode lead includes an elongate lead body and a nerve cuff. The nerve cuff may include a cuff body, with a front layer and a rear layer, affixed to the distal end of the lead body and a plurality of electrically conductive members located between the front and rear layers. Each of the electrically conductive member defines a front side, a rear side and an outer perimeter and may include a plurality of holes that extend from the front side to the rear side and that are located around the outer perimeter. The cuff body front layer includes a plurality of windows that are respectively aligned with and located inwardly of the outer perimeters of the electrically conductive members, and a plurality of window frames that extend from the windows to the outer perimeters of the electrically conductive members. The cuff body also includes a plurality of anchors that respectively extend through the electrically conductive member holes and connect the window frames to the cuff body rear layer.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Brydle, Jeffrey A.
Shelton, Brian
Dearden, Brian
Dai, Rongqing
Abstract
An electronic device, includes: a battery; a microcontroller configured to receive power from the battery along a first path comprising a first battery switch configured to change between an opened configuration and a closed configuration; and a receiver coil configured, in response to being positioned in a changing magnetic field, to generate an alternating electric current and to change, via the alternating electric current, the first battery switch from the opened configuration to the closed configuration.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Brydle, Jeffrey A.
Shelton, Brian
Dearden, Brian
Dai, Rongqing
Abstract
An electronic device, includes: a battery; a microcontroller configured to receive power from the battery along a first path comprising a first battery switch configured to change between an opened configuration and a closed configuration; and a receiver coil configured, in response to being positioned in a changing magnetic field, to generate an alternating electric current and to change, via the alternating electric current, the first battery switch from the opened configuration to the closed configuration.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Dai, William Alexander
Abstract
An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Hotlani, Hitesh
Abstract
An implantable medical device and a method of deduplicating data collected by the implantable medical device are provided. The method includes storing data, captured by the implantable medical device, in a non-volatile memory device of the implantable medical device, assigning a unique number, generated from a random number generator or counter, to each data block of the data, and deduplicating the data by deleting at least one of two or more data blocks that are associated with the same unique number.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Hotlani, Hitesh
Abstract
An implantable medical device and a method of deduplicating data collected by the implantable medical device are provided. The method includes storing data, captured by the implantable medical device, in a non-volatile memory device of the implantable medical device, assigning a unique number, generated from a random number generator or counter, to each data block of the data, and deduplicating the data by deleting at least one of two or more data blocks that are associated with the same unique number.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A61N 1/372 - Arrangements in connection with the implantation of stimulators
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
8.
ELECTRODE LEADS HAVING MULTI-APPLICATION HELICAL NERVE CUFFS AND ASSOCIATED SYSTEMS AND METHODS
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Brandt, William Andrew
Dearden, Brian Ralph
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Suri, Harshit
Lee, Edward K. F.
Abstract
In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Shelton, Brian
Mech, Brian
Elyahoodayan, Sahar
Abstract
A stimulation system configured to be implanted in a patient includes an implantable pulse generator (IPG) and an implantable lead system. The IPG includes a processor, a memory device, a power supply, and an inertial sensing unit configured to measure one or more physiological indicators of the patient. The implantable lead system includes at least one electrical lead coupled to the power supply and at least one electrode at a distal end of the electrical lead. The memory device includes instructions that cause the IPG to receive the physiological indicators within an initial range; increase the initial range to an enlarged range in response to the physiological indicators crossing a threshold maximum value or a threshold minimum value of the initial range; receive the physiological signals within the enlarged range, analyze the physiological indicators, and deliver stimulation to the patient through the electrode in response to the physiological indicators.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian
Mech, Brian
Elyahoodayan, Sahar
Abstract
A stimulation system configured to be implanted in a patient includes an implantable pulse generator (IPG) and an implantable lead system. The IPG includes a processor, a memory device, a power supply, and an inertial sensing unit configured to measure one or more physiological indicators of the patient. The implantable lead system includes at least one electrical lead coupled to the power supply and at least one electrode at a distal end of the electrical lead. The memory device includes instructions that cause the IPG to receive the physiological indicators within an initial range; increase the initial range to an enlarged range in response to the physiological indicators crossing a threshold maximum value or a threshold minimum value of the initial range; receive the physiological signals within the enlarged range, analyze the physiological indicators, and deliver stimulation to the patient through the electrode in response to the physiological indicators.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Jenney, Christopher, Reed
Talbot, Neil
Calderon, Joseph
Elyahoodayan, Sahar
Brandt, William, Andrew
Abstract
A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Jenney, Christopher Reed
Talbot, Neil
Calderon, Joseph L.
Elyahoodayan, Sahar
Brandt, William Andrew
Abstract
A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH, THE (USA)
Inventor
Shelton, Brian Michael
Mech, Brian
Klein, Valma
Talbot, Neil
Greenberg, Robert
Abstract
The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g., stimulation pulse amplitude) to levels that cause a therapeutic result in a matter of minutes instead of months as compared to related VNS systems.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Calderon, Joseph L.
Abstract
An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian Michael
Talbot, Neil
Dearden, Brian
Abstract
A stimulation device includes a first transmitting coil and a drive circuit electrically coupled to the first transmitting coil and configured to drive the first transmitting coil. The first transmitting coil is configured, when the device is in proximity to a person's ear and the first transmitting coil is driven with a time-varying electric current providable by the drive circuit, to generate at least part of a magnetic field providing a time-varying magnetic flux across an auricular branch of a Vagus Nerve (ABVN) sufficient to activate the ABVN.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian Michael
Mech, Brian
Klein, Valma
Talbot, Neil
Greenberg, Robert J.
Abstract
The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g., stimulation pulse amplitude) to levels that cause a therapeutic result in a matter of minutes instead of months as compared to related VNS systems.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Shelton, Brian Michael
Talbot, Neil
Dearden, Brian
Abstract
A stimulation device includes a first transmitting coil and a drive circuit electrically coupled to the first transmitting coil and configured to drive the first transmitting coil. The first transmitting coil is configured, when the device is in proximity to a person's ear and the first transmitting coil is driven with a time-varying electric current providable by the drive circuit, to generate at least part of a magnetic field providing a time-varying magnetic flux across an auricular branch of a Vagus Nerve (ABVN) sufficient to activate the ABVN.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Shelton, Brian Michael
Mech, Brian
Klein, Valma
Talbot, Neil
Hotlani, Hitesh
Abstract
The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Lin, Susanna
Dearden, Brian R.
Loo, Justin Cheng-Tsu
Abstract
A wireless power transfer device includes a first transmitting coil oriented along a first axis and including a first ferrite rod; a second transmitting coil on the first transmitting coil, oriented along a second axis different from the first axis, and including a second ferrite rod; and a nonmagnetic layer magnetically decoupling the first ferrite rod from the second ferrite rod in an area of overlap between the first and second ferrite rods, the first ferrite rod and the nonmagnetic layer being fabricated utilizing additive manufacturing.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Shelton, Brian Michael
Hotlani, Hitesh
Abstract
The disclosure provides systems and methods for system for vagus nerve stimulation (VNS), using a VNS stimulator implanted in a human subject and configured to transmit electrical stimulation pulses to a vagus nerve of the human subject; and at least one sensor configured to detect a predefined pattern of tactile input, a bodily gesture, and/or a voice command from the human subject, wherein the VNS stimulator includes a controller configured to modulate at least one stimulation parameter of the electrical stimulation pulses based at least in part on the tactile input, bodily gesture, and/or voice command from the human subject.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian Michael
Mech, Brian
Klein, Valma
Talbot, Neil
Hotlani, Hitesh
Abstract
The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian Michael
Hotlani, Hitesh
Abstract
The disclosure provides systems and methods for system for vagus nerve stimulation (VNS), using a VNS stimulator implanted in a human subject and configured to transmit electrical stimulation pulses to a vagus nerve of the human subject; and at least one sensor configured to detect a predefined pattern of tactile input, a bodily gesture, and/or a voice command from the human subject, wherein the VNS stimulator includes a controller configured to modulate at least one stimulation parameter of the electrical stimulation pulses based at least in part on the tactile input, bodily gesture, and/or voice command from the human subject.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Lin, Susanna
Dearden, Brian
Loo, Justin
Abstract
A wireless power transfer device (10) includes a first transmitting coil (100) oriented along a first axis (100a) and including a first ferrite rod (120); a second transmitting coil (200) on the first transmitting coil (100), oriented along a second axis (200a) different from the first axis (100a), and including a second ferrite rod (220); and a nonmagnetic layer (300L) magnetically decoupling the first ferrite rod (120) from the second ferrite rod (220) in an area of overlap (300) between the first and second ferrite rods (120, 220), the first ferrite rod (120) and the nonmagnetic layer (300L) being fabricated utilizing additive manufacturing.
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
H01F 3/08 - Cores, yokes or armatures made from powder
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 80/00 - Products made by additive manufacturing
25.
IMPLANTABLE MEDICAL DEVICE CHARGERS AND CHARGER POSITIONING SUPPORTS FOR USE WITH SAME
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Calderon, Joseph, L.
Hillery, Edward
Lin, Susanna, M.
Abstract
An implantable medical device (IMD) charger apparatus may include an IMD charger including a housing defining a bottom surface, a primary coil located within the housing, and a fastener on the bottom surface of the housing, and a charger support, mounted on the IMD charger, including a bottom surface, and movable between a first state and a second state. The IMD charger and the charger support may be respectively configured such that the IMD charger fastener is above the charger support bottom surface when the charger support is in the first state and the IMD charger fastener is at or below the charger support bottom surface when the charger support is in the second state.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H01F 27/00 - MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES - Details of transformers or inductances, in general
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Calderon, Joseph L.
Hillery, Edward
Lin, Susanna M.
Abstract
An implantable medical device (IMD) charger apparatus may include an IMD charger including a housing defining a bottom surface, a primary coil located within the housing, and a fastener on the bottom surface of the housing, and a charger support, mounted on the IMD charger, including a bottom surface, and movable between a first state and a second state. The IMD charger and the charger support may be respectively configured such that the IMD charger fastener is above the charger support bottom surface when the charger support is in the first state and the IMD charger fastener is at or below the charger support bottom surface when the charger support is in the second state.
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
The Alfred E Mann Foundation for Scientific Research (USA)
Inventor
Farkas, Leslie G.
Dearden, Brian R.
Loo, Justin Cheng-Tsu
Abstract
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Farkas, Leslie
Dearden, Brian
Loo, Justin
Abstract
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
29.
SYSTEMS AND METHODS FOR VAGUS NERVE MONITORING AND STIMULATION
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Mech, Brian V.
Talbot, Neil
Shelton, Brian M.
Calderon, Joseph L.
Greenberg, Robert J.
Abstract
The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g, epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g, vagal tone and/or physiological or other biomarkers).
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Mech, Brian V.
Talbot, Neil
Shelton, Brian M.
Calderon, Joseph L.
Greenberg, Robert J.
Abstract
The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g., epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g., vagal tone and/or physiological or other biomarkers).
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Jenney, Christopher, Reed
Strickland, Timothy
Abstract
An electrode lead including an elongate lead body and a nerve cuff (or other nerve contact element) including an electrically insulative cuff body (or other contact body) affixed to the distal end of the lead body and at least one electrically conductive coil partially embedded in the cuff body (or other contact body) such that there are non-embedded portions, which together define a flexible coil contact that is associated with the front outer surface of the cuff body (or other contact body), and embedded portions.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Schmidt, Siegmar
Dai, William A.
Ng, Boon Khai
Abstract
Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
G01L 7/08 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges of the flexible-diaphragm type
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
G01L 19/04 - Means for compensating for effects of changes of temperature
G01L 19/06 - Means for preventing overload or deleterious influence of the measured medium on the measuring device or vice versa
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Suri, Harshit
Calderon, Joseph L.
Molnar, Gregory Frederick
Goding, Jr., George S.
Atyabi, Alanie
Schmidt, Siegmar
Dai, William
Dearden, Brian
Keenan, Desmond B.
Abstract
An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Jenney, Christopher Reed
Strickland, Timothy
Abstract
An electrode lead including an elongate lead body and a nerve cuff (or other nerve contact element) including an electrically insulative cuff body (or other contact body) affixed to the distal end of the lead body and at least one electrically conductive coil partially embedded in the cuff body (or other contact body) such that there are non-embedded portions, which together define a flexible coil contact that is associated with the front outer surface of the cuff body (or other contact body), and embedded portions.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian
Shelton, Brian
Farkas, Leslie G.
Abstract
A wireless power transfer system includes a wireless power transfer device configured to determine a magnetic field, from among a plurality of directionally different potential magnetic fields that the wireless power transfer device is configured to generate, that has, at a receiver coil of an electronic device, a direction aligned with the receiver coil.
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof
G01P 15/02 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces
36.
METHOD AND APPARATUS FOR PRE-ALIGNMENT OF AN AUTOMATICALLY ALIGNING MAGNETIC FIELD SYSTEM
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian
Shelton, Brian
Farkas, Leslie G.
Abstract
A wireless power transfer system includes a wireless power transfer device configured to determine a magnetic field, from among a plurality of directionally different potential magnetic fields that the wireless power transfer device is configured to generate, that has, at a receiver coil of an electronic device, a direction aligned with the receiver coil.
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
37.
WAKEFULNESS AND SLEEP STAGE DETECTION USING RESPIRATION EFFORT VARIABILITY
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian Michael
Elyahoodayan, Sahar
Abstract
The present disclosure generally relates to systems and methods for monitoring and/or the sleep stage of an individual using one or more sensors, and methods of treating medical conditions related thereto (e.g., obstructive sleep apnea).
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Brandt, William Andrew
Dearden, Brian Ralph
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Brandt, William Andrew
Dearden, Brian Ralph
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Brandt, William, Andrew
Dearden, Brian, Ralph
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative helical cuff body configured to be disposed around a nerve, and a plurality of electrically conductive contacts carried by the helical cuff body that are spaced from one another.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Conducting medical and scientific research, and developing technology in the field of medical devices to bring advanced, innovative medical technologies to the public to improve the health and quality of life for people suffering from debilitating medical conditions; Compiling and analyzing data for research purposes in the field of medical devices; Medical, clinical, engineering and scientific research and development in the fields of medical devices, sensors and components thereof, and healthcare IT and infrastructure; Medical and scientific research, namely, conducting preclinical and clinical trials for others
42 - Scientific, technological and industrial services, research and design
Goods & Services
Conducting medical and scientific research, and developing technology in the field of medical devices, to bring advanced, innovative medical technologies to the public to improve the health and quality of life for people suffering from debilitating medical conditions; Compiling and analyzing data for research purposes in the field of medical devices; Medical, clinical, engineering and scientific research and development in the fields of medical devices, sensors and components thereof, and healthcare IT and infrastructure; Medical and scientific research, namely, conducting preclinical and clinical trials for others, all of the foregoing excluding consultation and research in the field of aerospace engineering and technology consultation and research in the field of aerospace engineering
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Mech, Brian
Greenberg, Robert
Abstract
The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Mech, Brian V.
Greenberg, Robert J.
Abstract
The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Mech, Brian V.
Greenberg, Robert J.
Abstract
The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Schmidt, Siegmar
Ng, Boon Khai
Abstract
An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Jenney, Christopher Reed
Gotlib, Oren
Calderon, Joseph
Brandt, William Andrew
Talbot, Neil
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Jenney, Christopher Reed
Gotlib, Oren
Calderon, Joseph
Brandt, William Andrew
Talbot, Neil
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Jenney, Christopher, Reed
Gotlib, Oren
Calderon, Joseph
Brandt, William, Andrew
Talbot, Neil
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Schmidt, Siegmar
Ng, Boon Khai
Abstract
An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Mech, Brian V.
Greenberg, Robert J.
Abstract
The disclosure provides systems and methods for detecting, monitoring, and/or treating obstructive sleep apnea, as well as other conditions, using vital sign and/or biometric data collected and/or imputed from one or more photoplethysmography sensors in conjunction with vital sign and/or biometric data from one or more additional sensors such as activity, body position, ECG, HR, or SpO2 levels, e.g., as feedback to control therapy and/or to titrate therapy on a periodic basis.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
52.
PHOTOPLETHYSMOGRAPHY IN COMBINATION WITH MEDICAL DEVICES
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Mech, Brian
Greenberg, Robert
Abstract
The disclosure provides systems and methods for detecting, monitoring, and/or treating obstructive sleep apnea, as well as other conditions, using vital sign and/or biometric data collected and/or imputed from one or more photoplethysmography sensors in conjunction with vital sign and/or biometric data from one or more additional sensors such as activity, body position, ECG, HR, or SpO2 levels, e.g., as feedback to control therapy and/or to titrate therapy on a periodic basis.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
54.
System and method for authenticating wireless programming devices in programmable medical systems
THE ALFRED E. MANN FOUNDATION FOR SCIENTIC RESEARCH (USA)
Inventor
Rodriguez, Saul
Han, Dianna (dan)
Istoc, Emil
Abstract
A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
H04L 69/40 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass for recovering from a failure of a protocol instance or entity, e.g. service redundancy protocols, protocol state redundancy or protocol service redirection
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H04L 67/53 - Network services using third party service providers
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
55.
System and method for authenticating wireless programming system and method for authenticating wireless programming devices in programmable medical systems
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Rodriguez, Saul
Han, Dianna (dan)
Istoc, Emil
Abstract
A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
H04L 69/40 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass for recovering from a failure of a protocol instance or entity, e.g. service redundancy protocols, protocol state redundancy or protocol service redirection
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H04L 67/53 - Network services using third party service providers
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Kohler, Daniel G.
Abstract
A method of multi-factor authentication includes receiving, by a first electronic device, a partial digital certificate including partial certificate information omitting at least one authentication factor from complete certificate information, and a signature encrypting a first hash of the complete certificate information with a certificate authority private key. The method also includes obtaining the first hash by decrypting, by the first electronic device, the signature with a certificate authority public key corresponding to the certificate authority private key; generating, by the first electronic device, a second hash based on the partial certificate information in the partial digital certificate and the at least one authentication factor; and comparing, by the first electronic device, the second hash to the first hash.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Kohler, Daniel G.
Abstract
A method of multi-factor authentication includes receiving, by a first electronic device, a partial digital certificate including partial certificate information omitting at least one authentication factor from complete certificate information, and a signature encrypting a first hash of the complete certificate information with a certificate authority private key. The method also includes obtaining the first hash by decrypting, by the first electronic device, the signature with a certificate authority public key corresponding to the certificate authority private key; generating, by the first electronic device, a second hash based on the partial certificate information in the partial digital certificate and the at least one authentication factor; and comparing, by the first electronic device, the second hash to the first hash.
G06F 21/33 - User authentication using certificates
G06F 21/34 - User authentication involving the use of external additional devices, e.g. dongles or smart cards
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Klein, Valma
Abstract
A multi-electrode ear shell includes an inner surface and an outer surface, the inner surface corresponding to a surface of an ear and being configured to overlap a cymba and a cavum of the ear. The multi-electrode ear shell further includes a first socket to receive a first stimulation electrode and a second socket to receive a second stimulation electrode.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Klein, Valma
Abstract
A multi-electrode ear shell includes an inner surface and an outer surface, the inner surface corresponding to a surface of an ear and being configured to overlap a cymba and a cavum of the ear. The multi-electrode ear shell further includes a first socket to receive a first stimulation electrode and a second socket to receive a second stimulation electrode.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Elyahoodayan, Sahar
Shelton, Brian M.
Talbot, Neil H.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Klein, Valma
Abstract
A multi-electrode ear shell includes an inner surface and an outer surface, the inner surface corresponding to a surface of an ear and being configured to overlap a cymba and a cavum of the ear. The multi-electrode ear shell further includes a first socket to receive a first stimulation electrode and a second socket to receive a second stimulation electrode.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Loo, Justin Cheng-Tsu
Abstract
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Loo, Justin Cheng-Tsu
Abstract
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Elyahoodayan, Sahar
Shelton, Brian M.
Talbot, Neil H.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Elyahoodayan, Sahar
Shelton, Brian M.
Talbot, Neal H.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Elyahoodayan, Sahar
Shelton, Brian, M.
Talbot, Neal, H.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Elyahoodayan, Sahar
Shelton, Brian M.
Talbot, Neal H.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Dearden, Brian R.
Loo, Justin Cheng-Tsu
Abstract
A wireless power transfer system includes a wireless power transfer device. The wireless power transfer device includes a first transmitting coil oriented along a first axis; a second transmitting coil on the first transmitting coil and oriented along a second axis different from the first axis; and a nonmagnetic material magnetically decoupling the first transmitting coil from the second transmitting coil in an area of overlap between the first and second transmitting coils.
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Elyahoodayan, Sahar
Shelton, Brian M.
Talbot, Neal H.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an inertial measurement unit (IMU) comprising an accelerometer and a gyroscope, wherein the IMU is configured to detect chest and/or abdominal movement by a patient during the inspiration and expiration stages of a respiratory cycle and to generate positional data based on the detected movement. Positional data generated by the IMU is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian Ralph
Shelton, Brian M.
Talbot, Neil
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian Ralph
Shelton, Brian, M.
Talbot, Neil
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Dearden, Brian Ralph
Shelton, Brian M.
Talbot, Neil
Abstract
An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian M.
Elyahoodayan, Sahar
Suri, Harshit R.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian M.
Elyahoodayan, Sahar
Suri, Harshit R.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Shelton, Brian M.
Elyahoodayan, Sahar
Suri, Harshit R.
Abstract
The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Greenberg, Robert J.
Suri, Harshit R.
Calderon, Joseph L.
Dearden, Brian R.
Abstract
Systems for treating obstructive sleep apnea having an implanted stimulator with an internal sensor configured to generate sensory data corresponding to movement of the thoracic or abdominal cavity of a patient during respiration. The system includes a wireless communications link between the stimulator and at least one external sensor for sensing a patient's physiological parameter and is used to augment the sensory data from the internal sensor. The stimulator includes a stimulation system configured to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Greenberg, Robert J.
Suri, Harshit R.
Calderon, Joseph L.
Dearden, Brian R.
Abstract
Systems for treating obstructive sleep apnea having an implanted stimulator with an internal sensor configured to generate sensory data corresponding to movement of the thoracic or abdominal cavity of a patient during respiration. The system includes a wireless communications link between the stimulator and at least one external sensor for sensing a patient's physiological parameter and is used to augment the sensory data from the internal sensor. The stimulator includes a stimulation system configured to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Greenberg, Robert J.
Suri, Harshit R.
Calderon, Joseph L.
Dearden, Brian R.
Abstract
Systems for treating obstructive sleep apnea having an implanted stimulator with an internal sensor configured to generate sensory data corresponding to movement of the thoracic or abdominal cavity of a patient during respiration. The system includes a wireless communications link between the stimulator and at least one external sensor for sensing a patient's physiological parameter and is used to augment the sensory data from the internal sensor. The stimulator includes a stimulation system configured to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve to treat sleep apnea.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Schmidt, Siegmar
Abstract
A lead comprising a lead body, a lead connector terminal affixed to a proximal end of the lead body, and a cuff body affixed to a distal end of the lead body, an electrode contact affixed to the cuff body, and an electrical conductor between the connector terminal and electrode contact. The lead further comprises a strap extending from a first region of the cuff body, a buckle disposed on a second region of the cuff body, and a locking feature, e.g., protuberance, ring, or wrinkle, associated with the strap. The locking feature is configured for being pulled through the buckle to dispose the cuff body around a nerve in response to a tensile force applied to the strap. The locking feature is configured for abutting an edge of the buckle in response to a release of the tensile force to secure the cuff body around the nerve.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Calderon, Joseph L.
Abstract
An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Suri, Harshit
Calderon, Joseph L.
Molnar, Gregory Frederick
Goding, Jr., George S.
Atyabi, Alanie
Schmidt, Siegmar
Dai, William
Dearden, Brian
Keenan, Desmond B.
Abstract
An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Suri, Harshit
Calderon, Joseph L.
Molnar, Gregory Frederick
Goding, Jr., George S.
Atyabi, Alanie
Schmidt, Siegmar
Dai, William
Dearden, Brian
Keenan, Desmond B.
Abstract
An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Schmidt, Siegmar
Dai, William A.
Ng, Boon Khai
Abstract
Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
G01L 7/08 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges of the flexible-diaphragm type
G01L 9/12 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in capacitance
G01L 19/04 - Means for compensating for effects of changes of temperature
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Rodriguez, Saul
Han, Dianna (dan)
Istoc, Emil
Abstract
A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
H04L 69/40 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass for recovering from a failure of a protocol instance or entity, e.g. service redundancy protocols, protocol state redundancy or protocol service redirection
A61N 1/372 - Arrangements in connection with the implantation of stimulators
H04L 67/53 - Network services using third party service providers
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
H04Q 9/00 - Arrangements in telecontrol or telemetry systems for selectively calling a substation from a main station, in which substation desired apparatus is selected for applying a control signal thereto or for obtaining measured values therefrom
H04W 12/04 - Key management, e.g. using generic bootstrapping architecture [GBA]
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
88.
Stimulator systems and methods for obstructive sleep apnea
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Suri, Harshit
Calderon, Joseph L.
Molnar, Gregory Frederick
Goding, Jr., George S.
Atyabi, Alanie
Schmidt, Siegmar
Dai, William
Dearden, Brian
Keenan, Desmond B.
Abstract
An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61B 1/267 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Lee, Edward K. F.
Abstract
A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
H03K 3/012 - Modifications of generator to improve response time or to decrease power consumption
H03K 3/023 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of differential amplifiers or comparators, with internal or external positive feedback
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Wolfe, James H.
Khemani, Manish
Abstract
A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
91.
Multiple implant communications with adjustable load modulation based on received signal amplitudes
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Lee, Edward K. F.
Suri, Harshit R.
Abstract
A medical system and method of communicating between a telemetry controller and medical devices is provided. Coupling coefficients between a primary coil of the telemetry controller and secondary coils of the medical devices differ from each other. A primary carrier signal is applied to the primary coil, thereby respectively inducing secondary carrier signals on the secondary coils. An amplitude of the secondary carrier signal is measured on each of the secondary coils. The envelope of each secondary carrier signal is modulated in accordance with data, thereby inducing modulation of the envelope of the primary carrier signal for the implanted medical devices. The secondary carrier signal envelopes are modulated based on the measured amplitudes of the respective secondary carrier signals.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Petrovich, John G.
Abstract
Skin patch sensors for monitoring and/or affecting body parameters, with alignment, positioning and attachment using magnets. The repeated use of releasable adhesive layers to retain skin patch sensors on skin can cause skin irritation, which can be reduced by rotating a skin patch between attachment times around a magnetically coupled pivot point. Skin patch sensors can be configured with internal coils to inductively couple to external power transmitting and communications coils with solenoids in anti-Helmholtz configurations.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Petrovich, John G.
Abstract
Skin patch sensors for monitoring and/or affecting body parameters, with alignment, positioning and attachment using magnets. The repeated use of releasable adhesive layers to retain skin patch sensors on skin can cause skin irritation, which can be reduced by rotating a skin patch between attachment times around a magnetically coupled pivot point. Skin patch sensors can be configured with internal coils to inductively couple to external power transmitting and communications coils with solenoids in anti-Helmholtz configurations.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Dearden, Brian R.
Petrovich, John G.
Abstract
Skin patch sensors for monitoring and/or affecting body parameters, with alignment, positioning and attachment using magnets. The repeated use of releasable adhesive layers to retain skin patch sensors on skin can cause skin irritation, which can be reduced by rotating a skin patch between attachment times around a magnetically coupled pivot point. Skin patch sensors can be configured with internal coils to inductively couple to external power transmitting and communications coils with solenoids in anti-Helmholtz configurations.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Schmidt, Siegmar
Ng, Boon Khai
Abstract
An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Jiang, Guangqiang
He, Tom
Abstract
The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.
The Alfred E. Mann Foundation for Scientific Research (USA)
Inventor
Schulman, Joseph H.
Hankin, David L.
Abstract
Biocompatible stiffness enhanced pliable electrically conductive filaments configured for contact with living tissue and electrical communication with such tissue. The pliability of the filaments allows the distal end of the filaments to remain at the original site of penetration into the tissue despite the movement of the tissue relative to their surrounding environment. To temporarily stiffen the filaments, a soluble stiffness enhancing coating is disposed over the filaments. The coating may be in the form of a liquid which dries to a solid state after being applied to the filaments and renders the filaments sufficiently rigid such that under appropriate force, the filaments are capable of penetrating into dense tissue. Once in place, the stiffness enhancing coating dissolves due to contact with body fluids, the filaments, in the absence of such a coating, return to their initial pliability.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Calderon, Joseph L.
Abstract
An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Calderon, Joseph L.
Abstract
An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (USA)
Inventor
Ng, Boon Khai
Calderon, Joseph L.
Abstract
An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.