Gen-Probe Incorporated

United States of America

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C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 58
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage 27
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor 22
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria 14
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system 13
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1.

COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGENS

      
Application Number US2023084251
Publication Number 2024/137379
Status In Force
Filing Date 2023-12-15
Publication Date 2024-06-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Barakat, Nesreen H.
  • Panuganti, Sree D.
  • Johnson, Tamara J.

Abstract

Yersinia enterocoliticaVibrioE. coliPlesiomonas shigelloidesPlesiomonas shigelloides target nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits. Methods of synthesizing the nucleic acid oligomers are also disclosed.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

2.

CELLULARITY CONTROL FOR NUCLEIC ACID ASSAYS

      
Application Number US2023076676
Publication Number 2024/081776
Status In Force
Filing Date 2023-10-12
Publication Date 2024-04-18
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Getman, Damon K.
  • Williams, Analee R.

Abstract

Disclosed are compositions and methods for performing nucleic-acid-based assays to determine the presence or absence of a target nucleic acid in a biological sample. The disclosed methods include the use of one or more oligomers that specifically hybridize to a nucleolin nucleic acid to assess the cellularity of the biological sample. Also disclosed are related composition and methods for assessing the cellularity of a biological sample for use in a molecular diagnostic assay.

IPC Classes  ?

  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

3.

METHOD OF DETECTING NUCLEIC ACID ANALYTES USING DUAL-SPECIFICITY PRIMERS

      
Application Number US2023073660
Publication Number 2024/054924
Status In Force
Filing Date 2023-09-07
Publication Date 2024-03-14
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Cappellari, Charles B.
  • Darby, Paul M.

Abstract

Provided are compositions, kits, and methods that can be used to selectively amplify a first target nucleic acid that is distinguishable from a second target nucleic acid, where the two target nucleic acids have both common and different sequence domains. Structured primers useful in the amplification method include 5' and 3' target-hybridizing sequences separated from each other by a joining region that does not hybridize to the target nucleic acid. Polymerase-based extension of the structured primer depends on specific hybridization of the 5' sequence of the primer, thereby facilitating hybridization and extension of the 3' sequence of the primer.

IPC Classes  ?

4.

COMPOSITIONS AND METHODS FOR DETECTION OF VIRAL PATHOGENS IN SAMPLES

      
Application Number US2023073357
Publication Number 2024/050540
Status In Force
Filing Date 2023-09-01
Publication Date 2024-03-07
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Carvallo Pinto, Marcela A.
  • Moberly, Joshua Kalani
  • Eaton, Barbara Lynn

Abstract

This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of SARS-CoV-2, Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

5.

JIG FOR POSITIONING AND SECURING A FIRST CONSOLE WITH RESPECT TO A SECOND CONSOLE

      
Application Number US2023011035
Publication Number 2023/141147
Status In Force
Filing Date 2023-01-18
Publication Date 2023-07-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran

Abstract

A jig assembly for connecting first and second consoles with predefined relative positioning includes first and second positioning pins attached or attachable to the first console and a positioning connection bracket attached or attachable to the second console and including a longitudinal span and first and second transverse legs including first and second pin recesses at respective free ends thereof. The first and second pin recesses receive the first and second positioning pins, respectively, when the first and second consoles are moved laterally toward each other. The first and second transverse legs may be attached to the first console with a first and second leg attachment brackets, respectively. The first and second positing pins and the first and second leg attachment brackets may be fixed with respect to the first console by attachment to a mounting rail that is fixed to the first console.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

6.

TEMPERATURE-SELECTABLE FRET CASSETTE SIGNALING

      
Application Number US2022077243
Publication Number 2023/056345
Status In Force
Filing Date 2022-09-29
Publication Date 2023-04-06
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gilly, Michael J.
  • Shah, Ankur H.
  • Gilder, Andrew S.

Abstract

i.e.i.e., "SNPs") in a temperature-dependent fashion using only a single fluorescence detection channel of a nucleic acid analyzer. The technique can be carried out using standard PCR instrumentation equipped for fluorescence detection or monitoring.

IPC Classes  ?

7.

AUTOMATED SYSTEMS AND METHODS FOR LOADING SOLID REAGENT PELLETS INTO WELLS OF A CARTRIDGE

      
Application Number US2022038639
Publication Number 2023/009699
Status In Force
Filing Date 2022-07-28
Publication Date 2023-02-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

Systems and methods for loading reagent pellets into wells of a cartridge include a pellet transfer head including vacuum nozzles corresponding to the number and arrangement of the wells of the cartridge, a pellet reservoir holding reagent pellets, a vision sensor system for performing various system vision checks, and vertical and horizontal carriage assemblies to effect relative movement between the transfer head, pellet reservoir, cartridge, and vision sensor system. The pellet transfer head may include downwardly-facing pressure ports to supply gas flow into the pellet supply reservoir to fluidize the supply of pellets and a static eliminator fan to eliminate or reduce static buildup among pellets in the reservoir. A pellet is drawn from the reservoir to each vacuum nozzle, and the vision sensor system confirms that a single, unbroken and undeformed pellet is positioned at each nozzle and then confirms transfer of a single pellet to each well.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

8.

COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGENS

      
Application Number US2022074151
Publication Number 2023/010008
Status In Force
Filing Date 2022-07-26
Publication Date 2023-02-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor Panuganti, Sree Divya

Abstract

Salmonella, Shigella, Campylobacter,Eschelichia coliEschelichia coli (STEC) in samples. In some embodiments, the compositions, methods, kits, and uses comprise one or more oligonucleotides or the use of one or more oligonucleotides. In some embodiments, the method is carried out as a multiplex assay with separate primers/probes for C.jejuni and C.coli. Some of the oligonucleotides contain inosine and/or contain 5-methylcytosine substituted nucleotides. Described is the use of cyclodextrin and/or Polysorbate 20 in the amplification reactions.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

9.

SYSTEM AND METHOD FOR EFFICIENTLY TRANSFERRING RECEPTACLES OUT OF A RECEPTACLE STORAGE AREA

      
Application Number US2022036925
Publication Number 2023/287858
Status In Force
Filing Date 2022-07-13
Publication Date 2023-01-19
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

Sample receptacles are automatically transferred from first and second storage areas of a storage module to a conveyor without passing over any other sample receptacle stored in the storage module. Receptacle holding positions in the first and second storage areas are arranged in rows and columns, and sample containers are transferred row-by-row or column-by-column, starting with sample container held closest to a first side of the first or second storage area. Receptacles transferred from the first storage area are transferred across the first side to the conveyor. Receptacles transferred from the second storage area are transferred across the first side into a first receptacle transport path between the first and second storage areas, and then to a second receptacle transport path across the first storage area, and then to the conveyor. To avoid passing a receptacle over another receptacle, receptacles are first removed from intervening holding positions between a respective holding position from which the receptacle is being transferred and the first side of the first or second storage area.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B65G 1/04 - Storage devices mechanical
  • B65G 47/90 - Devices for picking-up and depositing articles or materials
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

10.

ENZYME FORMULATIONS AND REACTION MIXTURES FOR NUCLEIC ACID AMPLIFICATION

      
Application Number US2022035456
Publication Number 2023/278529
Status In Force
Filing Date 2022-06-29
Publication Date 2023-01-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Chabot, Vincent J.
  • Filipowsky, Mark E.

Abstract

Disclosed are formulations and reaction mixtures comprising at least one polymerase, α-cyclodextrin, and polysorbate 20. Also disclosed are related methods for preparing the disclosed formulations and reaction mixtures, as well as related kits and methods for nucleic acid amplification. The formulations and reaction mixtures are useful, for example, in mitigating the inhibitory effect of sample extraction detergents on nucleic acid amplification reactions.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6851 - Quantitative amplification

11.

COMPOSITIONS AND METHODS FOR DETECTING HUMAN ADENOVIRUS NUCLEIC ACID

      
Application Number US2022029310
Publication Number 2022/241291
Status In Force
Filing Date 2022-05-13
Publication Date 2022-11-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor Moberly, Joshua Kalani

Abstract

Nucleic acid oligomers, including amplification oligomers and detection probes, for detection of human adenovirus nucleic acid by binding to the penton gene. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations. Nucleic acid oligomers and methods for nucleic acid amplification and detection of one or more adenovirus subgroups A, B, C, D, E and F are also disclosed.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

12.

COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE PROCESSING

      
Application Number US2022020256
Publication Number 2022/197637
Status In Force
Filing Date 2022-03-14
Publication Date 2022-09-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shapiro, Anne-Laure
  • Tuggle, James T.
  • Opalsky, David

Abstract

Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a sample transport media. The methods can provide efficient transfer of a target material such as cells or nucleic acid into the sample transport media for extraction, amplification, and detection of the target material.

IPC Classes  ?

13.

COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE PROCESSING

      
Application Number US2022020251
Publication Number 2022/197634
Status In Force
Filing Date 2022-03-14
Publication Date 2022-09-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shapiro, Anne-Laure
  • Tuggle, James T.
  • Opalsky, David
  • Nair, Sangeetha Vijaysri

Abstract

Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a sample transport media. The methods can provide efficient transfer of a target material such as cells or nucleic acid into the sample transport media for extraction, amplification, and detection of the target material.

IPC Classes  ?

  • A23K 20/189 - Enzymes
  • A23L 29/00 - Foods or foodstuffs containing additives; Preparation or treatment thereof
  • C12N 9/28 - Alpha-amylase from microbial source, e.g. bacterial amylase
  • A21D 8/04 - Methods for preparing dough; Treating dough prior to baking treating dough with microorganisms or enzymes
  • G01N 1/30 - Staining; Impregnating

14.

COMPOSITIONS AND METHODS FOR DETECTING INFLUENZA A, INFLUENZA B, AND SARS-COV-2

      
Application Number US2021057223
Publication Number 2022/094193
Status In Force
Filing Date 2021-10-29
Publication Date 2022-05-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Clark, Craig, Brian
  • Pham, Jimmykim
  • Darby, Paul, M.
  • Ho, Yi-Hsuan Elisha

Abstract

Disclosed are nucleic acid oligonucleotides, including primers, probes, and target capture oligonucleotides, for detection of SARS-CoV-2, Influenza A, and Influenza B. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligonucleotides. Corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations are described.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/686 - Polymerase chain reaction [PCR]

15.

AUTOMATED GRIPPING MECHANISM

      
Application Number US2021056000
Publication Number 2022/087233
Status In Force
Filing Date 2021-10-21
Publication Date 2022-04-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran

Abstract

A container gripping mechanism includes first and second linear rails disposed on opposed sides of a linear rail mount. A first linear rail guide coupled with the first rail is supported on a first gripper finger mount, and a second linear rail guide coupled with the second rail is supported on a second gripper finger mount. A first gripper finger is secured to the first gripper finger mount, and a second gripper finger is secured to the second gripper finger mount. A pinion gear driven by a drive motor engages racks attached to the first and second gripper finger mounts, such that rotation of the pinion in a first direction causes the first and second gripper fingers to move toward each other, and rotation of the pinion in a second direction causes the first and second gripper fingers to move away from each other.

IPC Classes  ?

16.

FLUID CONTAINER MANAGEMENT SYSTEM

      
Application Number US2021056039
Publication Number 2022/087257
Status In Force
Filing Date 2021-10-21
Publication Date 2022-04-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David A.
  • Hagen, Norbert D.
  • Opalsky, David

Abstract

Systems and methods for transferring containers (100) include or employ a container loading interface (200), a container storage module (400), and a container distributor (300) configured to transfer containers from the container loading interface to the container storage module. The container loading interface includes movable support platform (202) that is movable between accessible and a non-accessible positions and a container loading transport (214). The container storage module includes a housing (402) and a container storage transport (418). The container distributor includes a container gripper (320) configured to grasp a container on the container loading transport and to transfer the container to the container storage transport in the container storage module.

IPC Classes  ?

  • B65G 1/04 - Storage devices mechanical
  • B65G 47/84 - Star-shaped wheels or devices having endless travelling belts or chains, the wheels or devices being equipped with article-engaging elements
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • B65G 29/00 - Rotary conveyors, e.g. rotating discs, arms, star-wheels or cones
  • B01L 1/02 - Air-pressure chambers; Air-locks therefor

17.

DETECTION OF MACROLIDE-RESISTANT MYCOPLASMA GENITALIUM

      
Application Number US2021042222
Publication Number 2022/016153
Status In Force
Filing Date 2021-07-19
Publication Date 2022-01-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara, L.
  • Grobarczyk, Benjamin
  • Franzil, Laurent

Abstract

Mycoplasma genitaliumMycoplasma genitalium using FRET probes for detecting SNPs at position 2058 and 2059.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

18.

SYSTEM AND METHOD FOR DIFFERENTIAL MEASUREMENT OF A FLUID LEVEL IN A SAMPLE RECEPTACLE

      
Application Number US2021028719
Publication Number 2021/216929
Status In Force
Filing Date 2021-04-22
Publication Date 2021-10-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

Automated systems and methods determine a level of fluid relative to a rim of a sample receptacle defining an open top of the sample receptacle. The systems and methods utilize a distance sensor to measure the distance between the rim of the sample receptacle and the surface of a fluid sample contained in the sample receptacle, where at least one of the sensor and the sample receptacle is moved relative to the other to enable the sensor to obtain a sequence of discrete measurements of distances between the sensor and the rim of the sample receptacle and between the sensor and the surface of the fluid sample. A controller processes an output signal from the sensor to determine a level of the fluid relative to the rim of the sample receptacle. The derivative of the sequence of discrete measurements may be used to identify the rim and the fluid surface in the output signal.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

19.

GRIPPER APPARATUS WITH REDUCED CONTAMINATION RISK

      
Application Number US2021028721
Publication Number 2021/216931
Status In Force
Filing Date 2021-04-22
Publication Date 2021-10-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Combs, David H.

Abstract

A gripper apparatus is configured to grasp a closed receptacle having a closure affixed to an open top end of a receptacle. Opposed jaw members capable of lateral movement between an open position, a first closed position, and a second closed position are configured to grasp the closed receptacle when the closed receptacle is situated between the jaw members at the first closed position and to release the closed receptacle at the open position. The gripper apparatus further includes a plurality of fingers configured to grasp a sidewall of the closure beneath a top surface of the closure when the closure is situated between the plurality of fingers and beneath a base of each of the jaw members as the jaw members move laterally toward each other from the open position to the second closed position.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

20.

AUTOMATED PROCESSING OF SAMPLES CARRIED IN SAMPLE CONTAINERS AND GROUPING SAMPLE CONTAINERS ACCORDING TO ASSAYS TO BE PERFORMED ON SAMPLES CONTAINED THEREIN

      
Application Number US2021028722
Publication Number 2021/216932
Status In Force
Filing Date 2021-04-22
Publication Date 2021-10-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

A system for processing a plurality of sample containers, each containing sample with at least one open assay associated therewith, includes two or more analyzers, each configured to perform at least one functional assay in receptacle apparatuses including a process number of two or more receptacle vessels, a conveyance for transporting containers to the analyzers, a buffer queue associated with each analyzer for holding containers to be processed by the associated analyzer, and a scanner associated with each analyzer. Each scanner scans machine-readable identification information associated with each container transported by the conveyance past the scanner and the open assay(s) for that container are identified based on the scanned information. The sample container is diverted into the associated buffer queue only if at least one open assay for that container matches at least one functional assay of the associated analyzer. The system attempts to accumulate at least the process number of sample containers with the same open assay so that the matching functional assay can be performed on the different samples in each of the process number of receptacle vessels of each receptacle apparatus.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

21.

FLUID CONTAINER

      
Application Number US2021023683
Publication Number 2021/195083
Status In Force
Filing Date 2021-03-23
Publication Date 2021-09-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David
  • Knight, Byron J.

Abstract

A container includes a base with a top wall, a vessel depending from a top wall aperture in the top wall, a fluid retainer projecting above the top wall and surrounding the top wall aperture, and a skirt surrounding the vessel and including opposed grooves for gripping the container. A lid is disposed on a top end of the base and includes a cover wall with a lid aperture generally aligned with the top wall aperture of the base. A septum is disposed between the top wall of the base and the cover wall with a portion of the septum disposed between the lid aperture and the top wall aperture. Fluid retainer/return structure is configured to prevent fluid deposited on the septum from dripping off the container and to allow at least a portion of the fluid deposited on the septum to run off the septum and into the vessel.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

22.

COMPOSITIONS AND METHODS FOR DETECTING SARS-COV-2 NUCLEIC ACID

      
Application Number US2021020839
Publication Number 2021/178644
Status In Force
Filing Date 2021-03-04
Publication Date 2021-09-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shah, Ankur H.
  • Eaton, Barbara Lynn
  • Getman, Damon Kittredge
  • Moberly, Joshua Kalani
  • Darby, Paul M.
  • Pham, Jimmykim

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and capture probes, for detection of SARS-CoV-2 nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

23.

COMPOSITIONS AND METHODS FOR DETECTING CORONAVIRUS NUCLEIC ACID

      
Application Number US2020065487
Publication Number 2021/127099
Status In Force
Filing Date 2020-12-17
Publication Date 2021-06-24
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Moberly, Joshua Kalani
  • Peterson, Patrick Lynn
  • Allen, Megan Renee

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for amplification and/or detection of human coronavirus OC43, HKU1, NL63, and/or 229E nucleic acid. Also disclosed are methods of nucleic acid amplification and/or detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

24.

QUANTIFICATION OF POLYNUCLEOTIDE ANALYTES FROM DRIED SAMPLES

      
Application Number US2020064004
Publication Number 2021/119124
Status In Force
Filing Date 2020-12-09
Publication Date 2021-06-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Nair, Sangeetha Vijaysri
  • Wang, Xianqun

Abstract

Presented are methods, systems, and software products useful for determining the concentration of an analyte in a fluid specimen used to produce a dried sample, where the dried sample serves as a source of the analyte in a detection and quantification procedure. Particularly illustrated is the use of dried blood spots for quantifying a polynucleotide analyte.

IPC Classes  ?

  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase

25.

SYSTEM AND METHODS FOR LAB AUTOMATION DATA SHARING

      
Application Number US2020062703
Publication Number 2021/113238
Status In Force
Filing Date 2020-12-01
Publication Date 2021-06-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor Lanpheer, John

Abstract

A method for sharing system information data in a network of two or more diagnostic instruments for performing assays is provided. The system information data includes operating information for the diagnostic instruments in the network. The method includes: sending a system information metadata packet to at least a first diagnostic instrument in the network, wherein the system information metadata packet, is associated with system information data on a second diagnostic instrument in the network and comprises one or more attributes of a system information data packet containing the associated system information data; receiving a request from the first diagnostic instrument to send the system information data packet, and in response to the request from the first diagnostic instrument to send the system information data packet, sending the system information data packet containing the associated system information data to the first diagnostic instrument.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06Q 10/08 - Logistics, e.g. warehousing, loading or distribution; Inventory or stock management

26.

COMPOSITIONS AND METHODS FOR CAPTURING TARGET NUCLEIC ACIDS

      
Application Number US2020060594
Publication Number 2021/097358
Status In Force
Filing Date 2020-11-13
Publication Date 2021-05-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Carvallo Pinto, Marcela Alejandra
  • Shah, Ankur H.

Abstract

Capture mixtures and activated capture mixtures are provided that are useful for nucleic acid separation and purification are provided. The mixtures comprise lithium lauryl sulfate, lithium hydroxide, a zwitterionic sulfonic acid buffering agent, and optionally, proteinase K, capture probes comprising a first specific binding partner (SBP), and a second specific binding partner immobilized to a solid support. Related combinations, methods, uses, and kits, are also provided.

IPC Classes  ?

  • B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

27.

DETECTION OF CHLAMYDIA TRACHOMATIS NUCLEIC ACID VARIANTS

      
Application Number US2020049277
Publication Number 2021/046270
Status In Force
Filing Date 2020-09-03
Publication Date 2021-03-11
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Clark, Craig B.
  • Getman, Damon K.
  • Majlessi, Mehrdad R.
  • Walcher, Marion

Abstract

C. trachomatisC. trachomatis, including wildtype and/or variant sequences identified as FI-nvCT C1515T (SEQ ID NO:17), JP-nvCT C1522T (SEQ ID NO:12), US-nvCT G1526A (SEQ ID NO:22), and NO-nvCT G1523A (SEQ ID NO:27). Certain probes include nucleotide analogs to enhance desirable binding properties.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

28.

COMPOSITIONS, METHODS AND KITS FOR DETECTING TREPONEMA PALLIDUM

      
Application Number US2020046406
Publication Number 2021/041056
Status In Force
Filing Date 2020-08-14
Publication Date 2021-03-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • O'Donnell, Meghan, A.
  • Darby, Paul, M.
  • Getman, Damon, K.

Abstract

Treponema pallidumT. pallidumT. pallidumin vitroin vitro transcript. The presence of potentially cross-reacting non-target microorganisms does not negatively impact assay results.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

29.

RECEPTACLE TRANSPORT CARRIERS

      
Application Number US2020047990
Publication Number 2021/041537
Status In Force
Filing Date 2020-08-26
Publication Date 2021-03-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

A sample receptacle transporting carrier includes a base defining a recess for receiving a bottom end of the sample receptacle. The carrier also includes a plurality of resilient wire fingers affixed to and extending upward from the annular support. The fingers are configured to retain the bottom end of the sample receptacle within the recess of the base and to maintain the sample receptacle in an upright orientation. Each of the wire fingers includes a first segment adjacent to the base, a linear second segment joined to the first segment by a first angled portion, and a linear third segment joined to the second linear segment by a second angled portion. The third segment of each finger is configured to contact the bottom end of the receptacle as the receptacle is inserted into the carrier. The third segment and the vertical axis of the carrier form an angle between about 40⁰ and about 50⁰.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

30.

TRICHOMONAS VAGINALIS IN A SAMPLE

      
Application Number US2020040595
Publication Number 2021/003331
Status In Force
Filing Date 2020-07-02
Publication Date 2021-01-07
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Johnson, Tamara Jane Angeles
  • O'Donnell, Meghan Ann
  • Jiang, Alice

Abstract

Trichomonas vaginalisTrichomonas vaginalis Trichomonas vaginalis in a test sample.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
  • C12Q 1/6865 - Promoter-based amplification, e.g. nucleic acid sequence-based amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

31.

RECEPTACLE TRANSPORT SYSTEM FOR AN ANALYTICAL SYSTEM

      
Application Number US2020030481
Publication Number 2020/226969
Status In Force
Filing Date 2020-04-29
Publication Date 2020-11-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran
  • Buse, David Aaron
  • Combs, David H.

Abstract

A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first location.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

32.

SYSTEM AND METHOD FOR MANAGING LIQUID WASTE

      
Application Number US2020029238
Publication Number 2020/226897
Status In Force
Filing Date 2020-04-22
Publication Date 2020-11-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David, H.
  • Baker, Ayra
  • Hagen, Norbert, D.
  • Buse, David, A.

Abstract

A system for managing liquid waste includes a first liquid container that receives waste liquid, a liquid transfer pump fluidly connected to the first liquid container; and a second liquid container fluidly connectable to the liquid transfer pump. The liquid transfer pump is can be selectively activated to transfer liquid waste from the first liquid container to the second liquid container when the second liquid container is fluidly connected to the liquid transfer pump. A method for managing liquid waste includes the steps of receiving waste liquid into a first liquid container, monitoring the amount of liquid in the first container, connecting a second liquid container to a liquid transfer pump that is connected to the first liquid container, after the amount of liquid received into the first liquid container reaches a predefined level, transferring liquid from the first liquid container into the second liquid container with the liquid transfer pump, and removing liquid transferred to the second liquid container.

IPC Classes  ?

  • C02F 1/00 - Treatment of water, waste water, or sewage
  • C02F 9/00 - Multistage treatment of water, waste water or sewage
  • A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
  • C02F 103/00 - Nature of the water, waste water, sewage or sludge to be treated

33.

DISPOSABLE PIPETTE TIP MANAGEMENT

      
Application Number US2020023641
Publication Number 2020/205264
Status In Force
Filing Date 2020-03-19
Publication Date 2020-10-08
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David, H.
  • Hagen, Norbert, D.
  • Baker, Ayra
  • Ellis, Joseph, Reed

Abstract

After disposable pipette tips are used by an automated pipettor, they are released by the pipettor and fall into a waste container. When the waste container is removed to be emptied, the pipette tips are temporarily sequestered in a pipette tip holding station so that the automated pipettor may operate uninterrupted. After the waste container is replaced, the sequestered pipette tips are released by the holding station into the waste container.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

34.

COMPOSITIONS AND METHODS FOR DETECTING GROUP A STREPTOCOCCUS

      
Application Number US2020023815
Publication Number 2020/197987
Status In Force
Filing Date 2020-03-20
Publication Date 2020-10-01
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Panuganti, Sree Divya
  • Shah, Ankur

Abstract

Compositions, methods, kits, and uses are provided for detecting or quantifying a Group A Streptococcus (GAS) nucleic acid, e.g., using nucleic acid amplification and hybridization assays.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

35.

SYSTEM AND METHOD FOR TRANSPORTING AND HOLDING CONSUMABLES IN A PROCESSING INSTRUMENT

      
Application Number US2020021488
Publication Number 2020/181231
Status In Force
Filing Date 2020-03-06
Publication Date 2020-09-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David, H.
  • Buse, David, A.
  • Hagen, Norbert, D.
  • Opalsky, David
  • Chen, Jin

Abstract

A system and method provides a supply of consumables to a processing instrument that uses one or more of the consumables for each of a plurality of processes performed by the instrument. The system includes a loading drawer holding a carrier for receiving a plurality of consumables and an input module for holding a carrier supporting a plurality of consumables thereon and presenting the consumables for access by the instrument. A transporter includes a vertical elevator and a lateral actuator for moving a lift platform vertically and laterally and for transporting carriers on the lift platform with or without consumables supported thereon between the loading drawer and the input module, between the loading drawer and one or more holding shelves, or between the input module and one or more holding shelves. A carrier includes parallel support rails for holding multiple receptacle units and retainer tabs for retaining the units on the support rails.

IPC Classes  ?

  • B65G 47/74 - Feeding, transfer, or discharging devices of particular kinds or types
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

36.

DETECTION OF DRUG-RESISTANT MYCOPLASMA GENITALIUM

      
Application Number US2020014810
Publication Number 2020/154513
Status In Force
Filing Date 2020-01-23
Publication Date 2020-07-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Johnson, Tamara
  • Darby, Paul M.
  • Getman, Damon K.

Abstract

Mycoplasma genitalium.Mycoplasma genitalium. In one embodiment, real time Ct values determined for a wild type sequence and for a drug resistance marker, each on an opposite strand of the same amplification product, are compared to determine the presence or absence of the drug resistance marker in nucleic acids of a test sample.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

37.

SYSTEMS AND METHODS FOR FILLING MULTI-WELL CARTRIDGES WITH SOLID REAGENTS

      
Application Number US2019068570
Publication Number 2020/142347
Status In Force
Filing Date 2019-12-26
Publication Date 2020-07-09
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Bashar, Reza
  • Kindred, Andrew

Abstract

A tray for transferring a plurality of solid reagents to a multi-well cartridge, the tray including a top surface having a plurality of depressions formed therein, each depression being configured to receive and hold a single one of the solid reagents, and a barrier wall projecting above and substantially surrounding the top surface, where the barrier wall is discontinuous at a first end of the tray.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

38.

NUCLEIC ACID

      
Application Number US2019067777
Publication Number 2020/132408
Status In Force
Filing Date 2019-12-20
Publication Date 2020-06-25
Owner
  • GEN-PROBE INCORPORATED (USA)
  • GRIFOLS DIAGNOSTIC SOLUTIONS INC. (USA)
Inventor
  • Self, Deanna
  • Linnen, Jeffrey M.
  • Bres, Vanessa

Abstract

Plasmodium Plasmodium species nucleic acid in a sample. Also disclosed are methods of specific nucleic acid amplification and detection, including amplification and detection of target nucleic acid in real time, using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa

39.

COMPOSITIONS AND METHODS FOR AMPLIFYING, DETECTING OR QUANTIFYING HUMAN POLYOMAVIRUS BK VIRUS

      
Application Number US2019057383
Publication Number 2020/086546
Status In Force
Filing Date 2019-10-22
Publication Date 2020-04-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shah, Ankur
  • Yadav, Meghna

Abstract

e.g.e.g., using nucleic acid amplification and hybridization assays.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

40.

COMPOSITIONS AND METHODS FOR AMPLIFYING OR DETECTING VARICELLA-ZOSTER VIRUS

      
Application Number US2019053943
Publication Number 2020/072409
Status In Force
Filing Date 2019-10-01
Publication Date 2020-04-09
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Carvallo Pinto, Marcela Alejandra
  • Hillius, Amber Jean
  • Shah, Ankur

Abstract

Disclosed are oligonucleotides, oligonucleotide compositions, kits, methods, formulations, and reaction mixtures that provide for sensitive and specific detection of a target nucleic acid sequence, or amplicon generated from a target nucleic acid sequence, of Varicella-Zoster Virus (VZV1 (if present) in a sample. The oligonucleotides, compositions, kits, methods, formulations, and reaction mixtures can be used to detect the presence of VZV in a sample. The oligonucleotides, compositions, kits, methods, formulations, and reaction mixtures can also be used to amplify specific target nucleic acid regions of VZV.

IPC Classes  ?

  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

41.

PARAPERTUSSIS NUCLEIC ACID

      
Application Number US2019053099
Publication Number 2020/069085
Status In Force
Filing Date 2019-09-26
Publication Date 2020-04-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara L.
  • Grobarczyk, Benjamin
  • Barhdadi, Samira

Abstract

BordetellapertussisBordetella parapertussisBordetella parapertussis nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

42.

COMPOSITIONS AND METHODS FOR AMPLIFYING, DETECTING OR QUANTIFYING HUMAN CYTOMEGALOVIRUS

      
Application Number US2019047419
Publication Number 2020/041414
Status In Force
Filing Date 2019-08-21
Publication Date 2020-02-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Darby, Paul
  • Miick, Siobhan
  • Jackson, Jo Ann
  • Kim, Hee Cheol
  • Hillius, Amber
  • Shah, Ankur

Abstract

Oligomer nucleotides, compositions, methods, kits, and uses are provided for detecting or quantifying a Human Cytomegalovirus virus 1 (CMV (human herpesvirus 5, HHV5) nucleic acid, e.g., using nucleic acid amplification and hybridization assays. Multiphase amplification of a CMV target sequence is also described. The oligomer nucleotides, compositions, methods, kits, and uses can be used to amplify and/or detect the UL56 gene of CMV.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

43.

COMPOSITIONS AND METHODS FOR DETECTING BACTERIAL NUCLEIC ACID AND DIAGNOSING BACTERIAL VAGINOSIS

      
Application Number US2019047854
Publication Number 2020/041671
Status In Force
Filing Date 2019-08-23
Publication Date 2020-02-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Getman, Damon Kittredge
  • Hudson, Angela Sebring
  • Pham, Jimmykim
  • Wang, Xianqun
  • Clark, Caroline

Abstract

LactobacillusAtopobium vaginaeGardneralla vaginalisLactobacillus Atopobium vaginaeGardneralla vaginalisGardneralla vaginalis nucleic acid in a sample.

IPC Classes  ?

  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

44.

MYCOPLASMA GENITALIUM

      
Application Number US2019045520
Publication Number 2020/033557
Status In Force
Filing Date 2019-08-07
Publication Date 2020-02-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Kirkconnell, Brett W.
  • Weinbaum, Barbara S.
  • Getman, Damon K.
  • Jiang, Alice

Abstract

Mycoplasma genitaliumMycoplasma genitalium in a test sample. The oligonucleotides of the present disclosure may be incorporated into hybridization assay probes, capture probes and amplification primers, and used in various combinations thereof.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/686 - Polymerase chain reaction [PCR]

45.

COMPOSITIONS AND METHODS FOR DETECTING NUCLEIC ACIDS OF EPSTEIN-BARR VIRUS

      
Application Number US2019044614
Publication Number 2020/028631
Status In Force
Filing Date 2019-08-01
Publication Date 2020-02-06
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shah, Ankur
  • Fung, Jian Yu

Abstract

Disclosed are compositions, methods, and kits that can be used to Epstein-Barr virus (EBV) in a sample undergoing testing. Nucleic acids of EBV can be isolated, amplified and detected with specificity by real- time PCR, and without interference from non-EBV organisms. In some embodiments, nucleic acids used for amplification are isolated from human blood, or blood products. Nucleic acid isolation, amplification and detection steps can all be carried out using an automated instrument.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

46.

METHODS AND SYSTEMS FOR DETECTING AND QUANTIFYING NUCLEIC ACIDS

      
Application Number US2019041260
Publication Number 2020/014400
Status In Force
Filing Date 2019-07-10
Publication Date 2020-01-16
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Wang, Wilson
  • Tuggle, James T.
  • Shah, Ankur H.

Abstract

A system, method, computer, and computer readable medium enabling a user to quantify a target nucleic acid analyte.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6851 - Quantitative amplification
  • G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR

47.

SAMPLE PREPARATION METHOD AND SYSTEM

      
Application Number US2019037245
Publication Number 2020/005584
Status In Force
Filing Date 2019-06-14
Publication Date 2020-01-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Eaton, Barbara L.
  • Shah, Ankur

Abstract

in vitroin vitro nucleic acid amplification reaction. A biological sample is combined with an alkaline composition that lyses cells and denatures DNA to create a first liquid composition. The first liquid composition is then mixed with a buffer, a detergent, and a solid support that captures DNA to create a second liquid composition. The buffer, detergent, and solid support can be delivered as components of a single reagent. Captured DNA strands can be used as templates in subsequently performed nucleic acid amplification and detection reactions with improved sensitivity.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

48.

METHOD AND APPARATUS FOR FREEZING DISPENSED DROPLETS OF LIQUID

      
Application Number US2019037230
Publication Number 2019/245906
Status In Force
Filing Date 2019-06-14
Publication Date 2019-12-26
Owner GEN-PROBE INCORPORATED (USA)
Inventor Bashar, Reza

Abstract

A method and apparatus for freezing a liquid droplet includes dispensing, by a liquid dispenser (14), a droplet (13) of liquid into a fluid chamber (10) containing a freezing fluid (12). The droplet of liquid is allowed to dwell in the freezing fluid for at least a predetermined dwell time so that the droplet of liquid freezes to a frozen droplet. The method and apparatus further includes injecting, by a gas injector (17), a stream (16) of gas transversely to a surface of the freezing fluid at about where the frozen droplet is located along the surface of the freezing fluid contained in the fluid chamber so that the frozen droplet sinks in the freezing fluid.

IPC Classes  ?

  • F25D 3/11 - Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air with conveyors carrying articles to be cooled through the cooling space
  • F25C 1/00 - Producing ice

49.

COMPOSITIONS AND METHODS FOR DETECTING GROUP B STREPTOCOCCUS NUCLEIC ACID

      
Application Number IB2019056814
Publication Number 2019/239394
Status In Force
Filing Date 2019-08-09
Publication Date 2019-12-19
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara L.
  • Grobarczyk, Benjamin
  • Ozog, Yves
  • Close, Renaud
  • Franzil, Laurent

Abstract

Streptococcus agalactiaeStreptococcus agalactiae) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

50.

FAR-RED DYE PROBE FORMULATIONS

      
Application Number US2019016890
Publication Number 2019/157081
Status In Force
Filing Date 2019-02-06
Publication Date 2019-08-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Aubin-Walker, Sheila
  • Majlessi, Mehrdad R.
  • Pham, Jimmykim
  • Bousquet, Joshua

Abstract

Disclosed are formulations, including both liquid and lyophilized formulations, comprising a far-red dye probe and a non-linear surfactant or foamban. Also disclosed are related methods for preparing a lyophilized far-red dye probe formulation as well as related kits and diagnostic products.

IPC Classes  ?

  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

51.

ANALYTICAL SYSTEMS AND METHODS

      
Application Number US2019015589
Publication Number 2019/148169
Status In Force
Filing Date 2019-01-29
Publication Date 2019-08-01
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer L.
  • Shapiro, Anne-Laure
  • Rhubottom, Jason F.
  • Lio, Alberto A.
  • Scheer, Timothy J.
  • Tuggle, James T.
  • Shah, Ankur H.
  • Opalsky, David

Abstract

A system, method and computer readable medium enabling a user to specify user-defined assay parameters of an assay protocol for processing a sample and causing a computer-controlled analyzer to perform an assay in accordance with the assay protocol.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/686 - Polymerase chain reaction [PCR]

52.

METHODS FOR BIOLOGICAL SAMPLE PROCESSING

      
Application Number US2018065105
Publication Number 2019/118550
Status In Force
Filing Date 2018-12-12
Publication Date 2019-06-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor Peterson, Patrick Lynn

Abstract

Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a wash liquid, wherein a first portion of the aliquot is released into the wash liquid; and transferring the swab into a carrier liquid, wherein a second portion of the aliquot is released into the carrier liquid. The methods can provide efficient transfer of analyte such as cells or nucleic acid into the carrier liquid while releasing particulate matter, viscous polymers, or other undesired material into the wash liquid. Alternatively or in addition, the methods can also release desired material into the wash liquid, e.g., cells, which can be used in applications such as culturing.

IPC Classes  ?

  • G01N 1/00 - Sampling; Preparing specimens for investigation

53.

COMPOSITIONS AND METHODS FOR DETECTING TOXIGENIC CLOSTRIDIUM DIFFICILE

      
Application Number US2018065470
Publication Number 2019/118735
Status In Force
Filing Date 2018-12-13
Publication Date 2019-06-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor Peterson, Patrick Lynn

Abstract

C. difficile tcdAtcdtcdcdt cdttcdtcdtcdtcdC are detected.

IPC Classes  ?

  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

54.

COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID

      
Application Number US2018061225
Publication Number 2019/099629
Status In Force
Filing Date 2018-11-15
Publication Date 2019-05-23
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Miick, Siobhán M.
  • Darby, Paul M.
  • Jackson, Jo Ann
  • Getman, Damon K.

Abstract

This disclosure provides oligomers, combinations of oligomers, compositions, kits, uses, and methods for detecting a C1orf43 nucleic acid, such as C1orf43 mRNA, such as human C1orf43 mRNA, in a sample.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

55.

COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS

      
Application Number US2018045975
Publication Number 2019/032809
Status In Force
Filing Date 2018-08-09
Publication Date 2019-02-14
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick
  • Darby, Paul
  • Jost, Matthias
  • Miick, Siobhan
  • Brentnall, Matthew
  • Jackson, Joann

Abstract

Staphylococcus aureusmecmecA, mecCS. aureus-S. aureus-specific gene.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

56.

OPTICAL SIGNAL DETECTION MODULES AND METHODS

      
Application Number US2018043594
Publication Number 2019/023294
Status In Force
Filing Date 2018-07-25
Publication Date 2019-01-31
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert
  • Walker, George
  • Combs, David

Abstract

An apparatus for detecting an optical signal emissions includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers, and configured to detect an optical signal emitted by each signal emission source.

IPC Classes  ?

57.

ANALYTICAL SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION USING SAMPLE ASSIGNING PARAMETERS

      
Application Number US2018041472
Publication Number 2019/014239
Status In Force
Filing Date 2018-07-10
Publication Date 2019-01-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer, L.
  • Shapiro, Ann-Laure
  • Shah, Ankur, H.
  • Tuggle, James, T.
  • Opalsky, David
  • Lio, Alberto, A.
  • Scheer, Timothy, J.
  • Rhubottom, Jason, F.
  • Buse, David, Aaron

Abstract

Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system-defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

58.

RECEPTACLE HOLDERS, SYSTEMS, AND METHODS FOR CAPACITIVE FLUID LEVEL DETECTION

      
Application Number US2018041286
Publication Number 2019/014124
Status In Force
Filing Date 2018-07-09
Publication Date 2019-01-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Pham, Trung Q.
  • Jeffers Ii, Jerry W.
  • Buse, David
  • Grubbs, Steven G.

Abstract

A receptacle holder for supporting at least one fluid-containing receptacle includes a body and an RFID transponder. The body includes an electrically conductive portion defining a first recess configured to receive at least a first fluid-containing receptacle, and an electrically non-conductive portion attached to the electrically conductive portion. The RFID transponder is disposed on the electrically non-conductive portion of the body, and stores information about the receptacle holder. The receptacle holder can also include the first fluid-containing receptacle received within the first recess.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 9/00 - Supporting devices; Holding devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

59.

DETECTING BABESIA SPECIES NUCLEIC ACID IN A SAMPLE

      
Application Number US2018036214
Publication Number 2018/226798
Status In Force
Filing Date 2018-06-06
Publication Date 2018-12-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Bres, Vanessa
  • Self, Deanna
  • Linnen, Jeffrey M.

Abstract

There is described herein a method for specifically detecting Babesia species nucleic acid in a sample, which in one aspect comprises: (1) contacting a sample, said sample suspected of containing Babesia species nucleic acid, with at least two oligomers for amplifying a target region of a Babesia species target nucleic acid, wherein the at least two amplification oligomers comprise: (a) a first amplification oligomer comprising a first target-hybridizing sequence (i) that is from about 15 to about 33 contiguous nucleotides in length, is contained in the sequence of SEQ ID NO:66 and comprises SEQ ID NO:56 or 57; or (ii) that is from about 15 to about 33 contiguous nucleotides in length, is contained in the sequence of SEQ ID NO:96 and comprises SEQ ID NO:101; or (iii) that is from about 15 to about 33 contiguous nucleotides in length, is contained in the sequence of SEQ ID NO:97 and comprises SEQ ID NO:101; (iv) comprises or consists of SEQ ID NO:8; (v) comprises or consists of SEQ ID NO:83 and (b) a second amplification oligomer comprising a second target-hybridizing sequence that is from about 15 to about 33 contiguous nucleotides in length, and (i) is contained in SEQ ID NO:68 and comprises SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, or SEQ ID NO:85; or (ii) is contained in SEQ ID NO:67 and comprises SEQ ID NO:45 or SEQ ID NO:52;or (iii) is contained in SEQ ID NO:70 and comprises SEQ ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, or SEQ ID NO:51; (2) performing an in vitro nucleic acid amplification reaction, wherein any Babesia target nucleic acid present in said sample is used as a template for generating an amplification product; and (3) detecting the presence or absence of the amplification product, thereby indicating the presence or absence of Babesia species target nucleic acid in said sample.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa

60.

DRIED COMPOSITIONS CONTAINING FLAP ENDONUCLEASE

      
Application Number US2018033549
Publication Number 2018/213811
Status In Force
Filing Date 2018-05-18
Publication Date 2018-11-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick
  • Luu, Tony
  • Jost, Matthias

Abstract

There is disclosed a composition of an aqueous solution comprising, consisting or consisting essentially of a flap endonuclease, a bulking agent and an organic buffer, wherein the aqueous solution has an inorganic salt concentration of 5 mM or less and wherein the composition is substantially free of glycerol.

IPC Classes  ?

  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

61.

COMPOSITIONS AND METHODS FOR ISOLATING TARGET NUCLEIC ACIDS

      
Application Number US2018032044
Publication Number 2018/209068
Status In Force
Filing Date 2018-05-10
Publication Date 2018-11-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor Shah, Ankur

Abstract

Populations of target capture probes are provided that are useful for nucleic acid separation and purification. The probes of the population comprise a first region that is at least about 12 residues in length and comprises a poly(r) sequence comprising (i) a randomized sequence comprising G and A nucleotides, or (ii) a non-randomized repeating (A and G) sequence; and a second region comprising a first specific binding partner (SBP), wherein the SBP is capable of specifically binding a second specific binding partner (SBP2). Related combinations, methods, uses, kits, and reaction mixtures are also provided.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

62.

COMPOSITIONS, METHODS AND KITS TO DETECT ADENOVIRUS, METAPNEUMOVIRUS AND/OR RHINOVIRUS NUCLEIC ACIDS

      
Application Number US2018024141
Publication Number 2018/183124
Status In Force
Filing Date 2018-03-23
Publication Date 2018-10-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Shah, Ankur
  • Hillius, Amber
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

The disclosed disclosure is related to methods, compositions, and kits for targeting Adenovirus, Metapneumovirus, and/or Rhinovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

63.

LABELS, RECEPTACLES, SYSTEMS, AND METHODS FOR AUTOMATIC SAMPLE PROCESSING

      
Application Number US2018025463
Publication Number 2018/183890
Status In Force
Filing Date 2018-03-30
Publication Date 2018-10-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

A sample receptacle can be used for ordering assays to be performed by an automatic sample processing instrument. The sample receptacle can include a body defining a chamber for containing a sample and a label. The label can include discrete areas configured to be altered from a first assay order state to a second assay order state. Each discrete area has a known association with a different assay. The label can also include assay-identifying indicia indicating the respective assay associated with a respective discrete area. A method of processing a sample in a receptacle having one or more assay order states can include automatically determining assay order states of the discrete areas and performing an assay on the sample, using the automatic sample processing instruments, based on the determined assay order states of the discrete areas.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

64.

COMPOSITIONS AND METHODS FOR DETECTION OF VIRAL PATHOGENS IN SAMPLES

      
Application Number US2018023995
Publication Number 2018/175868
Status In Force
Filing Date 2018-03-23
Publication Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Douglass, Pamela
  • Kolk, Daniel P.
  • Majlessi, Mehrdad R.

Abstract

This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

65.

SYSTEM FOR MIXING CONTENTS OF CONTAINERS AND RELATED METHODS OF USE

      
Application Number US2018024016
Publication Number 2018/175880
Status In Force
Filing Date 2018-03-23
Publication Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor Buse, David, A.

Abstract

A method for mixing fluids in containers may include performing a mixing procedure on a plurality of containers (128, 130) on a container support (110), at least a portion of the plurality of containers being differently sized. The mixing procedure may include a plurality of mixing phases, wherein in each mixing phase the container support may be subjected to a mixing motion at a single rate for a period of time of about 5 seconds or longer, and wherein the single rate for at least one mixing phase of the plurality of mixing phases may differ from the single rate for at least one other mixing phase of the plurality of mixing phases. The mixing procedure also may include at least one non-mixing phase, wherein the container support may not be subjected to the mixing motion.

IPC Classes  ?

  • B01F 9/00 - Mixers with rotating receptacles
  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • B01F 15/00 - Accessories for mixers

66.

FLUID RECEPTACLES

      
Application Number US2018023352
Publication Number 2018/175434
Status In Force
Filing Date 2018-03-20
Publication Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor Knight, Byron

Abstract

A receptacle for minimizing evaporation of a fluid includes a single-piece body, a fluid-tight seal, a penetrable septum, and a lid coupled to the body. The body includes a first chamber having a first opening. The fluid-tight seal is affixed to a surface of the body that defines the first opening. The fluid-tight seal covers the first opening and is frangible. The septum covers the first opening and the fluid-tight seal. The lid has an opening axially aligned with the first opening. The septum comprises slits forming flaps The first chamber can be the only chamber containing a fluid, or the single-piece body may also include another chamber containing the fluid. The other chamber can be in fluid communication with the first chamber via a conduit. The fluid-tight seal can also cover the opening of the second chamber.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B65D 47/20 - Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge

67.

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING PARAINFLUENZA VIRUS

      
Application Number US2018024021
Publication Number 2018/175883
Status In Force
Filing Date 2018-03-23
Publication Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

Compositions, methods, kits, and uses are provided for detecting or quantifying an Human Parainfluenza virus 1 (HPIV-1), HPIV-2, HPIV-3, and/or HPIV-4 nucleic acid, e.g., using nucleic acid amplification and hybridization assays. In some embodiments, the compositions, methods, kits, and uses target the HN gene of HPIV-1, HPIV-2, and/or HPIV-3 and/or the NP gene of HPIV-4.

IPC Classes  ?

  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

68.

SYSTEMS AND METHODS FOR CAPACITIVE FLUID LEVEL DETECTION, AND HANDLING CONTAINERS

      
Application Number US2018024081
Publication Number 2018/175923
Status In Force
Filing Date 2018-03-23
Publication Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Opalsky, David
  • Buse, David
  • Tuggle, James T.
  • Navarro, Alex
  • Sheehan, Patrick

Abstract

A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01F 25/00 - Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
  • G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

69.

COVER ASSEMBLY AND RELATED METHODS OF USE

      
Application Number US2018024175
Publication Number 2018/175985
Status In Force
Filing Date 2018-03-23
Publication Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor Buse, David, A.

Abstract

A cover assembly may include a tray assembly frame, a first cover supported by the tray assembly frame, the first cover extending in a first plane and defining one or more first openings; a second cover supported by the tray assembly frame, the second cover extending in a second plane and defining one or more second openings, wherein the first and second planes are different planes, and wherein the second cover is disposed above the first cover. The cover assembly may include one or more tray holders, each tray holder being configured to hold at least one tray in an upright orientation, wherein each tray holder is moveable between an open position and a closed position, the tray holders being accessible for loading or removing the trays in the open position, and the tray holders being positioned beneath the first and second covers in the closed position.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

70.

EVAPORATION-LIMITING INSERTS FOR REAGENT CONTAINERS AND RELATED METHODS OF USE

      
Application Number US2018020680
Publication Number 2018/160979
Status In Force
Filing Date 2018-03-02
Publication Date 2018-09-07
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Knight, Byron J.
  • Chabot, Vincent

Abstract

An insert for a liquid-holding container may include a body comprising a wall, open first and second ends, and a lumen extending from the open first end to the open second end. The insert also may include a plurality of first openings formed in the wall, the first openings being situated between the first and second ends, and each of the first openings defining an area, and one or more second openings formed in the wall, the one or more second openings being situated between the first and second ends, each of the one or more second openings defining an area that is greater than the area defined by any of the first openings, where at least one of the one or more second openings is situated closer to the first end than any of the first openings, and wherein each of the first and second openings is sized to permit the passage of a liquid.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

71.

LABORATORY AUTOMATED INSTRUMENTS, SYSTEMS, AND METHODS FOR TRANSPORTING SAMPLE RECEPTACLE CARRIERS

      
Application Number US2017064179
Publication Number 2018/102663
Status In Force
Filing Date 2017-12-01
Publication Date 2018-06-07
Owner GEN-PROBE INCORPORATED (USA)
Inventor Lair, Gary

Abstract

A laboratory automated system can include a host conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto between at least a sample processing instrument and at least one assay instrument. The system includes an intermediate conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto from within sample processing instrument to the host conveyor assembly. The system also includes an intermediate conveyor assembly for each assay instrument configured to transport a plurality of carriers from host conveyor assembly to a respective processing position within the assay instrument. The intermediate conveyor assembly coupled to the assay instrument can include a buffer conveyor subassembly configured to receive carriers from the host conveyor assembly, and a spur conveyor assembly configured to transport a carrier to the processing position of the assay instrument.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

72.

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS B VIRUS

      
Application Number US2017062229
Publication Number 2018/094171
Status In Force
Filing Date 2017-11-17
Publication Date 2018-05-24
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Linnen, Jeffrey M.

Abstract

This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

73.

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS C VIRUS

      
Application Number US2017057178
Publication Number 2018/075633
Status In Force
Filing Date 2017-10-18
Publication Date 2018-04-26
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Miick, Siobhan
  • Darby, Paul, M.
  • Jackson, Jo, A.
  • Aubin, Sheila, M.J.

Abstract

This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis C virus (HCV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the 5' untranslated region of HCV and are configured to provide substantially equivalent quantification of different genotypes and variants of HCV.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

74.

COMPOSITIONS ON PLASMA-TREATED SURFACES

      
Application Number US2017054325
Publication Number 2018/064491
Status In Force
Filing Date 2017-09-29
Publication Date 2018-04-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Knight, Byron J.
  • Opalsky, David

Abstract

The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.

IPC Classes  ?

  • C08J 7/06 - Coating with compositions not containing macromolecular substances
  • C08J 7/18 - Chemical modification with polymerisable compounds using wave energy or particle radiation

75.

COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID

      
Application Number US2017036764
Publication Number 2017/214511
Status In Force
Filing Date 2017-06-09
Publication Date 2017-12-14
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Linnen, Jeffrey M.

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

76.

BLOOD CELL LYSIS REAGENT

      
Application Number US2017029671
Publication Number 2017/189746
Status In Force
Filing Date 2017-04-26
Publication Date 2017-11-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Chelliserry, Jijumon
  • Linnen, Jeffrey

Abstract

Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

77.

ASSEMBLIES FOR STORING SAMPLE PROCESSING CONSUMABLES, SAMPLE PROCESSING INSTRUMENTS, AND METHODS

      
Application Number US2017027420
Publication Number 2017/180873
Status In Force
Filing Date 2017-04-13
Publication Date 2017-10-19
Owner GEN-PROBE INCORPORATED (USA)
Inventor Knight, Byron

Abstract

An assembly for storing sample processing consumables can include a cover and a tray. The cover defines a cover cavity. The tray defines a first plurality of wells. The tray includes a first portion received within the cover cavity such that a press fit is formed between a first tray surface of the first portion of the tray and a first cover surface of the cover defining the cover cavity, thereby releasably coupling the cover to the tray. Each of the first plurality of wells contains a sample processing consumable. The assembly can be used to load sample processing consumables into a sample processing instrument.

IPC Classes  ?

  • B01L 9/06 - Test-tube stands; Test-tube holders
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • B01L 9/00 - Supporting devices; Holding devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

78.

LABORATORY AUTOMATED INSTRUMENTS, SYSTEMS, AND METHODS

      
Application Number US2017018133
Publication Number 2017/143037
Status In Force
Filing Date 2017-02-16
Publication Date 2017-08-24
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Walker, George T.
  • Merten, Matthias
  • Lair, Gary D.

Abstract

A laboratory automated system can include a host conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto between at least a sample processing instrument and at least one assay instrument. The system includes an intermediate conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto from within sample processing instrument to the host conveyor assembly. The system also includes an intermediate conveyor assembly for each assay instrument configured to transport a plurality of carriers from host conveyor assembly to a respective processing position within the assay instrument. The intermediate conveyor assembly coupled to the assay instrument can include a buffer conveyor subassembly configured to receive carriers from the host conveyor assembly, and a spur conveyor assembly configured to transport a carrier to the processing position of the assay instrument.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

79.

DRIED AMPLIFICATION COMPOSITIONS

      
Application Number US2017016592
Publication Number 2017/136782
Status In Force
Filing Date 2017-02-03
Publication Date 2017-08-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Mauch, Steven
  • Dickson, Robert Stephen
  • Jost, Matthias
  • Filipowsky, Mark
  • Martin, Donald
  • Nodelman, Vladislav
  • Crowell, Cheryl Lynn

Abstract

The disclosure provides dried compositions providing reagents for nucleic acid amplification, which are essentially free of inorganic salts. Lack of inorganic salts increases stability of such compositions and decreases formation of byproducts. Salts required for use of enzymes in the composition are supplied on reconstitution.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

80.

METHODS AND COMPOSITIONS FOR DETECTING CANDIDA SPECIES

      
Application Number US2017012163
Publication Number 2017/120216
Status In Force
Filing Date 2017-01-04
Publication Date 2017-07-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hudson, Angela S.
  • Getman, Damon K.
  • Jiang, Alice
  • Eaton, Barbara L.

Abstract

Disclosed are methods utilizing specific amplification of Candida sp. target nucleic acid for detecting the presence or absence of Candida sp. in a sample. Also disclosed are corresponding oligomers, including amplification oligomers, capture probes and detection probes, and combinations thereof, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

81.

SYSTEMS AND METHODS FOR ANALYZING A SAMPLE AND FOR MONITORING THE PERFORMANCE OF AN OPTICAL SIGNAL DETECTOR

      
Application Number US2016068384
Publication Number 2017/117011
Status In Force
Filing Date 2016-12-22
Publication Date 2017-07-06
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Opalsky, David
  • Raghuwanshi, Srajan
  • Bui, James

Abstract

A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.

IPC Classes  ?

  • G01N 21/03 - Cuvette constructions
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
  • G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

82.

SYSTEMS AND METHODS FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES

      
Application Number US2016058452
Publication Number 2017/070663
Status In Force
Filing Date 2016-10-24
Publication Date 2017-04-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor Opalsky, David

Abstract

A sample processing or assay instrument (100) includes a moveable support (112). The moveable support (112) defines a first pocket (140A) configured to receive a first object (136) having a first machine-readable mark (147). The moveable support (112) defines a second pocket (140B) configured to receive a second object (136) having a second machine-readable mark (147). The moveable support (112) also includes a first fiducial machine-readable mark (150A) and a second fiducial machine-readable mark (150B). The instrument also includes an image capture device (128) that captures a first image including the first fiducial machine-readable mark (150A) and the first machine-readable mark (147) of the first object (136). The image capture device (128) captures a second image that includes the second fiducial machine-readable mark (150B) and the second machine-readable mark (147) of the second object (136). The instrument (100) also includes a processor configured to associate information decoded from the first and second machine-readable marks (150A, 150B) with first and second locations on the moveable support (112).

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation

83.

APPARATUS FOR MAINTAINING A CONTROLLED ENVIRONMENT

      
Application Number US2016045166
Publication Number 2017/023934
Status In Force
Filing Date 2016-08-02
Publication Date 2017-02-09
Owner GEN-PROBE INCORPORATED (USA)
Inventor Knight, Byron J.

Abstract

A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

IPC Classes  ?

  • F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
  • A01N 1/02 - Preservation of living parts
  • B01L 9/06 - Test-tube stands; Test-tube holders
  • F26B 25/06 - Chambers, containers, or receptacles

84.

METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES

      
Application Number US2016036439
Publication Number 2016/200933
Status In Force
Filing Date 2016-06-08
Publication Date 2016-12-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Opalsky, David
  • Walker, George T.
  • Knight, Byron J.

Abstract

An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

IPC Classes  ?

  • G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
  • G01N 21/64 - Fluorescence; Phosphorescence

85.

METHOD OF POOLING BLOOD SAMPLES

      
Application Number US2016032011
Publication Number 2016/183282
Status In Force
Filing Date 2016-05-12
Publication Date 2016-11-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Linnen, Jeffrey M.
  • Chelliserry, Jijumon

Abstract

The disclosure provides methods of pooled analysis of samples containing red blood cells, such as whole blood cell samples. The methods are particularly useful for screening whole blood samples collected from many individuals to be used for transfusions and the like. Aliquots of such samples are individually contacted with a lysis reagent, further described below, before pooling to lyse red blood cells in the samples. After pooling, the lysates, the combined lysate is tested for presence of target(s) characteristic of pathogen(s). The method are particularly useful for identifying pathogens of red blood cells, but can also be used to run a complete panel of testing including for all of the typical targets.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

86.

MULTIPLEX INVASIVE CLEAVAGE ASSAYS

      
Application Number US2016030416
Publication Number 2016/179093
Status In Force
Filing Date 2016-05-02
Publication Date 2016-11-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick L.
  • King, Joe
  • Hall, Jeff

Abstract

The present disclosure relates to compositions and methods, and related systems, products and kits, for performing temperature-dependent multiplex invasive cleavage assays, where a plurality of target nucleic acids are detected and distinguished from each other in a procedure using only a single fluorescent moiety as the reporter, and single channel fluorescence detection. In some embodiments, at least one of the plurality of target nucleic acids is an amplified nucleic acid, where progress in a thermal cycling amplification reaction is monitored as a function of time (i.e., real-time amplification).

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

87.

SYSTEMS AND METHODS FOR READING MACHINE-READABLE LABELS ON SAMPLE RECEPTACLES

      
Application Number US2016026237
Publication Number 2016/164473
Status In Force
Filing Date 2016-04-06
Publication Date 2016-10-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert
  • Opalsky, David
  • Silbert, Rolf

Abstract

Systems for reading machine-readable labels, for example, two-dimensional barcodes, include a housing, a reader configured to read the machine-readable labels on sample receptacles as a sample rack holding the sample receptacles move between a first position and a second position within the housing. The system includes a processing and control unit configured to decode a read image of the machine-readable labels on each sample receptacle, and configured to associate a decoded read images with the corresponding sample receptacles based on measured positions of the sample rack when the machine-readable label was read.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

88.

SAMPLE TESTING SYSTEMS AND METHODS WITH AUTOMATED CLEANING

      
Application Number US2016026669
Publication Number 2016/164740
Status In Force
Filing Date 2016-04-08
Publication Date 2016-10-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Knight, Byron J.
  • Opalsky, David

Abstract

A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.

IPC Classes  ?

  • B08B 11/00 - Cleaning flexible or delicate articles by methods or apparatus specially adapted thereto
  • G01N 21/03 - Cuvette constructions
  • G01N 21/15 - Preventing contamination of the components of the optical system or obstruction of the light path
  • B08B 9/00 - Cleaning hollow articles by methods or apparatus specially adapted thereto
  • B08B 1/00 - Cleaning by methods involving the use of tools, brushes, or analogous members

89.

METHODS AND COMPOSITIONS FOR DETECTING BACTERIAL NUCLEIC ACID AND DIAGNOSING BACTERIAL VAGINOSIS

      
Application Number US2016022628
Publication Number 2016/149357
Status In Force
Filing Date 2016-03-16
Publication Date 2016-09-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara L.
  • Getman, Damon K.
  • Pawlowski, Traci

Abstract

Disclosed are methods for diagnosing Bacterial Vaginosis in a subject comprising performing an assay for the detection of any one or more of Lactobacillus sp., Gardneralla vaginalis, and Eggerthella sp. in a subject sample. Also disclosed are methods and compositions for detecting Lactobacillus sp., Gardneralla vaginalis, and/or Eggerthella nucleic acid in a sample.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

90.

METHODS AND COMPOSITIONS FOR DIAGNOSING BACTERIAL VAGINOSIS

      
Application Number US2016012589
Publication Number 2016/112252
Status In Force
Filing Date 2016-01-08
Publication Date 2016-07-14
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Graham, Michael
  • Hall, Jeffrey
  • King, Joseph, J.

Abstract

Disclosed are methods for diagnosing Bacterial Vaginosis (BV). The disclosed methods generally include detecting select species of Eggerthella and/or Prevotella, and optionally detecting select species of Lactobacillus. Also disclosed are nucleic acid oligomers and related compositions for detection of a 16S rRNA or its encoding gene from select species of Eggerthella, Prevotella, or Lactobacillus.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor

91.

RED BLOOD CELL LYSIS SOLUTION

      
Application Number US2015056480
Publication Number 2016/064887
Status In Force
Filing Date 2015-10-20
Publication Date 2016-04-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Chelliserry, Jijumon
  • Gao, Kui
  • Linnen, Jeffrey M.

Abstract

The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anticoagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 33/483 - Physical analysis of biological material
  • C12N 5/078 - Cells from blood or from the immune system

92.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

      
Application Number US2015056763
Publication Number 2016/065072
Status In Force
Filing Date 2015-10-21
Publication Date 2016-04-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Rosati, Robert
  • Buse, David
  • Tammer, Olev
  • Merten, Matthias

Abstract

A printing module (10) configured to print a label on a curved surface of an article (12) includes an expandable printing mechanism (50) configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head (152) and an article moving assembly (260) configured to grasp and hold the article and effect relative movement between the curved surface and the print head (152). The printing mechanism includes contact elements, such as rollers (72,74), that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head (152) during relative movement between the curved surface and the print head (152).

IPC Classes  ?

  • B41J 3/407 - Typewriters or selective printing or marking mechanisms characterised by the purpose for which they are constructed for marking on special material
  • B41J 2/32 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by selective application of heat to a heat sensitive printing or impression-transfer material using thermal heads

93.

DEVICE FOR RELEASABLY HOLDING AN ELONGATED OBJECT IN A PREDETERMINED ORIENTATION AND SYSTEM FOR TRANSPORTING AN ELONGATED OBJECT DISPOSED IN A PREDETERMINED ORIENTATION

      
Application Number US2015044870
Publication Number 2016/025606
Status In Force
Filing Date 2015-08-12
Publication Date 2016-02-18
Owner GEN-PROBE INCORPORATED (USA)
Inventor Lair, Gary, D.

Abstract

A device for releasably holding an elongated object, such as a test tube, in a predetermined orientation includes a gripping element configured for circumferential expansion and contraction with respect to the object. An actuator element coupled to the gripping element is configured to effect circumferential expansion of the gripping element to an expanded configuration able to receive an end of the elongated object. A locking mechanism coupled to the actuator element is configured to lock the actuator element in a position holding the gripping element in the expanded configuration. A lock release mechanism is configured to be triggered by an elongated object inserted into the expanded gripping element and to release the locking mechanism, thereby allowing the biased gripping element to return to a contracted configuration gripping a portion of the object. The device and an object held thereby can be conveyed on a conveyor.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • B01L 9/06 - Test-tube stands; Test-tube holders

94.

METHOD OF ISOLATING NUCLEIC ACID FROM SPECIMENS IN LIQUID-BASED CYTOLOGY PRESERVATIVES CONTAINING FORMALDEHYDE

      
Application Number US2014000064
Publication Number 2015/130255
Status In Force
Filing Date 2014-03-21
Publication Date 2015-09-03
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Wilson, Timothy Joseph
  • Kirkconnell, Brett Wolfe
  • Jensen, Deborah Christine

Abstract

Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains formaldehyde. The technique relies on the use of 2-imidazolidone and a protease enzyme, such as proteinase K, at elevated temperatures. Advantageously, RNA can be isolated and used as a template in nucleic acid amplification reactions.

IPC Classes  ?

  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

95.

COMPOSITIONS AND METHODS FOR DETECTING HEV NUCLEIC ACID

      
Application Number US2014051145
Publication Number 2015/023892
Status In Force
Filing Date 2014-08-14
Publication Date 2015-02-19
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Ong, Edgar O.
  • Cole, Jennifer
  • Linnen, Jeffrey M.

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

96.

APPARATUS FOR DETECTING SIGNAL EMISSIONS FROM A PLURALITY OF FLUORESCENT SOURCES

      
Application Number US2014021820
Publication Number 2014/159066
Status In Force
Filing Date 2014-03-07
Publication Date 2014-10-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert, D.
  • Opalsky, David

Abstract

An indexing signal detection module (100) is configured to index one or more signal detectors (200) past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits (180) transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter (150) is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.

IPC Classes  ?

  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01N 21/64 - Fluorescence; Phosphorescence

97.

APPARATUS FOR INDEXING AND AGITATING FLUID CONTAINERS

      
Application Number US2014029161
Publication Number 2014/153116
Status In Force
Filing Date 2014-03-14
Publication Date 2014-09-25
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David, Aaron
  • Knight, Byron, J.

Abstract

An apparatus configured for mixing the contents of one or more fluid containers includes a fluid container support platform configured to hold one or more fluid containers. The fluid container support platform is configured to index the container to one or more specified locations and to be moved in an orbital path about an orbital center independently of the rotation about the central axis of rotation. The apparatus further includes an indexing drive system configured to effect indexing movement of the container support platform and a vortex drive system configured to effect powered orbital movement of the container support platform about the orbital center. An evaporation limiting insert placed within containers reduces exposure of the fluid contents of the container to atmospheric air, thereby reducing susceptibility of the fluid contents to evaporation.

IPC Classes  ?

  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

98.

SYSTEMS, METHODS, AND APPARATUSES FOR PERFORMING AUTOMATED REAGENT-BASED ASSAYS

      
Application Number US2014026789
Publication Number 2014/151996
Status In Force
Filing Date 2014-03-13
Publication Date 2014-09-25
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Knight, Byron, J.
  • Buse, David
  • Groeli, Julian

Abstract

System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

99.

DIAGNOSTIC SYSTEMS AND METHODS

      
Application Number US2014029538
Publication Number 2014/153193
Status In Force
Filing Date 2014-03-14
Publication Date 2014-09-25
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David, Aaron
  • Opalsky, David
  • Rhubottom, Jason
  • Hagen, Norbert
  • Tidd, Jennifer

Abstract

A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

100.

CALIBRATION METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT

      
Application Number US2014027628
Publication Number 2014/143665
Status In Force
Filing Date 2014-03-14
Publication Date 2014-09-18
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Nair, Sangeetha Vijaysri
  • Wang, Xianqun
  • Yamagata, Susan K.

Abstract

Method and system for quantifying target nucleic acids using real-time amplification and internal calibration adjustment. The approach employs a single fixed data point, which may be obtained from an external instrument, in combination with a single adjustment calibrator amplified on the instrument that is to be calibrated for approximating a complete calibration curve.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G06F 19/20 - for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation
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