Gen-Probe Incorporated

United States of America

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C12Q 1/6844 - Nucleic acid amplification reactions 37
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters 34
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage 34
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 27
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor 26
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1.

TEMPERATURE-SELECTABLE FRET CASSETTE SIGNALING

      
Document Number 03232383
Status Pending
Filing Date 2022-09-29
Open to Public Date 2023-04-06
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gilly, Michael J.
  • Shah, Ankur H.
  • Gilder, Andrew S.

Abstract

A multiplexed nucleic acid amplification and detection system useful for detecting the presence of multiple specific nucleic acid sequences or single nucleotide polymorphisms (i.e., "SNPs") in a temperature-dependent fashion using only a single fluorescence detection channel of a nucleic acid analyzer. The technique can be carried out using standard PCR instrumentation equipped for fluorescence detection or monitoring.

IPC Classes  ?

2.

COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGENS

      
Document Number 03226812
Status Pending
Filing Date 2022-07-26
Open to Public Date 2023-02-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor Panuganti, Sree Divya

Abstract

Compositions, methods, kits, and uses are provided for detecting the presence of Salmonella, Shigella, Campylobacter, and Shigatoxigenic Eschelichia coli (STEC) in samples. In some embodiments, the compositions, methods, kits, and uses comprise one or more oligonucleotides or the use of one or more oligonucleotides. In some embodiments, the method is carried out as a multiplex assay with separate primers/probes for C.jejuni and C.coli. Some of the oligonucleotides contain inosine and/or contain 5-methylcytosine substituted nucleotides. Described is the use of cyclodextrin and/or Polysorbate 20 in the amplification reactions.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

3.

ENZYME FORMULATIONS AND REACTION MIXTURES FOR NUCLEIC ACID AMPLIFICATION

      
Document Number 03220932
Status Pending
Filing Date 2022-06-29
Open to Public Date 2023-01-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Chabot, Vincent J.
  • Filipowsky, Mark E.

Abstract

Disclosed are formulations and reaction mixtures comprising at least one polymerase, a-cyclodextrin, and polysorbate 20. Also disclosed are related methods for preparing the disclosed formulations and reaction mixtures, as well as related kits and methods for nucleic acid amplification. The formulations and reaction mixtures are useful, for example, in mitigating the inhibitory effect of sample extraction detergents on nucleic acid amplification reactions.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6851 - Quantitative amplification

4.

COMPOSITIONS AND METHODS FOR DETECTING HUMAN ADENOVIRUS NUCLEIC ACID

      
Document Number 03218222
Status Pending
Filing Date 2022-05-13
Open to Public Date 2022-11-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor Moberly, Joshua Kalani

Abstract

Nucleic acid oligomers, including amplification oligomers and detection probes, for detection of human adenovirus nucleic acid by binding to the penton gene. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations. Oligomers and methods of detecting one or more groups selected from group A, B, C, D, E and F are also disclosed.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

5.

COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE PROCESSING

      
Document Number 03211659
Status Pending
Filing Date 2022-03-14
Open to Public Date 2022-09-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shapiro, Anne-Laure
  • Tuggle, James T.
  • Opalsky, David
  • Nair, Sangeetha Vijaysri

Abstract

Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a sample transport media. The methods can provide efficient transfer of a target material such as cells or nucleic acid into the sample transport media for extraction, amplification, and detection of the target material.

IPC Classes  ?

  • A23K 20/189 - Enzymes
  • A23L 29/00 - Foods or foodstuffs containing additives; Preparation or treatment thereof
  • A21D 8/04 - Methods for preparing dough; Treating dough prior to baking treating dough with microorganisms or enzymes
  • C12N 9/28 - Alpha-amylase from microbial source, e.g. bacterial amylase
  • G01N 1/30 - Staining; Impregnating

6.

COMPOSITIONS AND METHODS FOR DETECTING INFLUENZA A, INFLUENZA B, AND SARS-COV-2

      
Document Number 03191332
Status Pending
Filing Date 2021-10-29
Open to Public Date 2022-05-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Clark, Craig Brian
  • Pham, Jimmykim
  • Darby, Paul M.
  • Ho, Yi-Hsuan Elisha

Abstract

Disclosed are nucleic acid oligonucleotides, including primers, probes, and target capture oligonucleotides, for detection of SARS-CoV-2, Influenza A, and Influenza B. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligonucleotides. Corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations are described.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

7.

FLUID CONTAINER MANAGEMENT SYSTEM

      
Document Number 03177256
Status Pending
Filing Date 2021-10-21
Open to Public Date 2022-04-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David A.
  • Hagen, Norbert D.
  • Opalsky, David

Abstract

Systems and methods for transferring containers (100) include or employ a container loading interface (200), a container storage module (400), and a container distributor (300) configured to transfer containers from the container loading interface to the container storage module. The container loading interface includes movable support platform (202) that is movable between accessible and a non-accessible positions and a container loading transport (214). The container storage module includes a housing (402) and a container storage transport (418). The container distributor includes a container gripper (320) configured to grasp a container on the container loading transport and to transfer the container to the container storage transport in the container storage module.

IPC Classes  ?

  • B65G 1/04 - Storage devices mechanical
  • B01L 1/02 - Air-pressure chambers; Air-locks therefor
  • B65G 29/00 - Rotary conveyors, e.g. rotating discs, arms, star-wheels or cones
  • B65G 47/84 - Star-shaped wheels or devices having endless travelling belts or chains, the wheels or devices being equipped with article-engaging elements
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

8.

AUTOMATED GRIPPING MECHANISM

      
Document Number 03197629
Status Pending
Filing Date 2021-10-21
Open to Public Date 2022-04-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran

Abstract

A container gripping mechanism includes first and second linear rails disposed on opposed sides of a linear rail mount. A first linear rail guide coupled with the first rail is supported on a first gripper finger mount, and a second linear rail guide coupled with the second rail is supported on a second gripper finger mount. A first gripper finger is secured to the first gripper finger mount, and a second gripper finger is secured to the second gripper finger mount. A pinion gear driven by a drive motor engages racks attached to the first and second gripper finger mounts, such that rotation of the pinion in a first direction causes the first and second gripper fingers to move toward each other, and rotation of the pinion in a second direction causes the first and second gripper fingers to move away from each other.

IPC Classes  ?

9.

DETECTION OF MACROLIDE-RESISTANT MYCOPLASMA GENITALIUM

      
Document Number 03188657
Status Pending
Filing Date 2021-07-19
Open to Public Date 2022-01-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara, L.
  • Grobarczyk, Benjamin
  • Franzil, Laurent

Abstract

Provided are methods, compositions, and systems for detecting nucleic acids of macrolide-resistant Mycoplasma genitalium using FRET probes for detecting SNPs at position 2058 and 2059.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

10.

GRIPPER APPARATUS WITH REDUCED CONTAMINATION RISK

      
Document Number 03176900
Status Pending
Filing Date 2021-04-22
Open to Public Date 2021-10-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Combs, David H.

Abstract

A gripper apparatus is configured to grasp a closed receptacle having a closure affixed to an open top end of a receptacle. Opposed jaw members capable of lateral movement between an open position, a first closed position, and a second closed position are configured to grasp the closed receptacle when the closed receptacle is situated between the jaw members at the first closed position and to release the closed receptacle at the open position. The gripper apparatus further includes a plurality of fingers configured to grasp a sidewall of the closure beneath a top surface of the closure when the closure is situated between the plurality of fingers and beneath a base of each of the jaw members as the jaw members move laterally toward each other from the open position to the second closed position.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

11.

SYSTEM AND METHOD FOR DIFFERENTIAL MEASUREMENT OF A FLUID LEVEL IN A SAMPLE RECEPTACLE

      
Document Number 03177253
Status Pending
Filing Date 2021-04-22
Open to Public Date 2021-10-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

Automated systems and methods determine a level of fluid relative to a rim of a sample receptacle defining an open top of the sample receptacle. The systems and methods utilize a distance sensor to measure the distance between the rim of the sample receptacle and the surface of a fluid sample contained in the sample receptacle, where at least one of the sensor and the sample receptacle is moved relative to the other to enable the sensor to obtain a sequence of discrete measurements of distances between the sensor and the rim of the sample receptacle and between the sensor and the surface of the fluid sample. A controller processes an output signal from the sensor to determine a level of the fluid relative to the rim of the sample receptacle. The derivative of the sequence of discrete measurements may be used to identify the rim and the fluid surface in the output signal.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

12.

AUTOMATED PROCESSING OF SAMPLES CARRIED IN SAMPLE CONTAINERS AND GROUPING SAMPLE CONTAINERS ACCORDING TO ASSAYS TO BE PERFORMED ON SAMPLES CONTAINED THEREIN

      
Document Number 03176901
Status Pending
Filing Date 2021-04-22
Open to Public Date 2021-10-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

A system for processing a plurality of sample containers, each containing sample with at least one open assay associated therewith, includes two or more analyzers, each configured to perform at least one functional assay in receptacle apparatuses including a process number of two or more receptacle vessels, a conveyance for transporting containers to the analyzers, a buffer queue associated with each analyzer for holding containers to be processed by the associated analyzer, and a scanner associated with each analyzer. Each scanner scans machine-readable identification information associated with each container transported by the conveyance past the scanner and the open assay(s) for that container are identified based on the scanned information. The sample container is diverted into the associated buffer queue only if at least one open assay for that container matches at least one functional assay of the associated analyzer. The system attempts to accumulate at least the process number of sample containers with the same open assay so that the matching functional assay can be performed on the different samples in each of the process number of receptacle vessels of each receptacle apparatus.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

13.

FLUID CONTAINER

      
Document Number 03176069
Status Pending
Filing Date 2021-03-23
Open to Public Date 2021-09-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David
  • Knight, Byron J.

Abstract

A container includes a base with a top wall, a vessel depending from a top wall aperture in the top wall, a fluid retainer projecting above the top wall and surrounding the top wall aperture, and a skirt surrounding the vessel and including opposed grooves for gripping the container. A lid is disposed on a top end of the base and includes a cover wall with a lid aperture generally aligned with the top wall aperture of the base. A septum is disposed between the top wall of the base and the cover wall with a portion of the septum disposed between the lid aperture and the top wall aperture. Fluid retainer/return structure is configured to prevent fluid deposited on the septum from dripping off the container and to allow at least a portion of the fluid deposited on the septum to run off the septum and into the vessel.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

14.

COMPOSITIONS AND METHODS FOR DETECTING SARS-COV-2 NUCLEIC ACID

      
Document Number 03174532
Status Pending
Filing Date 2021-03-04
Open to Public Date 2021-09-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shah, Ankur H.
  • Eaton, Barbara Lynn
  • Getman, Damon Kittredge
  • Moberly, Joshua Kalani
  • Darby, Paul M.
  • Pham, Jimmykim

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and capture probes, for detection of SARS-CoV-2 nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits and related methods for preparing aqueous reaction mixtures from dried formulations.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

15.

QUANTIFICATION OF POLYNUCLEOTIDE ANALYTES FROM DRIED SAMPLES

      
Document Number 03163936
Status Pending
Filing Date 2020-12-09
Open to Public Date 2021-06-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Nair, Sangeetha Vijaysri
  • Wang, Xianqun

Abstract

Presented are methods, systems, and software products useful for determining the concentration of an analyte in a fluid specimen used to produce a dried sample, where the dried sample serves as a source of the analyte in a detection and quantification procedure. Particularly illustrated is the use of dried blood spots for quantifying a polynucleotide analyte.

IPC Classes  ?

  • C12Q 1/6851 - Quantitative amplification
  • G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation
  • G16C 20/00 - Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers

16.

SYSTEM AND METHODS FOR LAB AUTOMATION DATA SHARING

      
Document Number 03163473
Status Pending
Filing Date 2020-12-01
Open to Public Date 2021-06-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor Lanpheer, John

Abstract

A method for sharing system information data in a network of two or more diagnostic instruments for performing assays is provided. The system information data includes operating information for the diagnostic instruments in the network. The method includes: sending a system information metadata packet to at least a first diagnostic instrument in the network, wherein the system information metadata packet, is associated with system information data on a second diagnostic instrument in the network and comprises one or more attributes of a system information data packet containing the associated system information data; receiving a request from the first diagnostic instrument to send the system information data packet, and in response to the request from the first diagnostic instrument to send the system information data packet, sending the system information data packet containing the associated system information data to the first diagnostic instrument.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

17.

COMPOSITIONS AND METHODS FOR CAPTURING TARGET NUCLEIC ACIDS

      
Document Number 03159392
Status Pending
Filing Date 2020-11-13
Open to Public Date 2021-05-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Carvallo Pinto, Marcela Alejandra
  • Shah, Ankur H.

Abstract

Capture mixtures and activated capture mixtures are provided that are useful for nucleic acid separation and purification are provided. The mixtures comprise lithium lauryl sulfate, lithium hydroxide, a zwitterionic sulfonic acid buffering agent, and optionally, proteinase K, capture probes comprising a first specific binding partner (SBP), and a second specific binding partner immobilized to a solid support. Related combinations, methods, uses, and kits, are also provided.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
  • B01J 20/282 - Porous sorbents

18.

DETECTION OF CHLAMYDIA TRACHOMATIS NUCLEIC ACID VARIANTS

      
Document Number 03153514
Status Pending
Filing Date 2020-09-03
Open to Public Date 2021-03-11
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Clark, Craig B.
  • Getman, Damon K.
  • Majlessi, Mehrdad R.
  • Walcher, Marion

Abstract

Hybridization probe reagents that specifically detect nucleic acids of C. trachomatis, including wildtype and/or variant sequences identified as FI-nvCT C1515T (SEQ ID NO:17), JP-nvCT C1522T (SEQ ID NO:12), US-nvCT G1526A (SEQ ID NO:22), and NO-nvCT G1523A (SEQ ID NO:27). Certain probes include nucleotide analogs to enhance desirable binding properties.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

19.

COMPOSITIONS, METHODS AND KITS FOR DETECTING TREPONEMA PALLIDUM

      
Document Number 03152309
Status Pending
Filing Date 2020-08-14
Open to Public Date 2021-03-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • O'Donnell, Meghan A.
  • Darby, Paul M.
  • Getman, Damon K.

Abstract

Presented are oligonucleotide hybridization probes, primer sets, methods, reaction mixtures, and kits for detecting nucleic acids of Treponema pallidum, the causative agent of syphilis. Disclosed assays are both highly sensitive and specific for detection of T. pallidum nucleic acids. Nucleic acid sequences of T. pallidum can be detected at a level of 100% positivity using test samples having only 30 copies/ml of a model in vitro transcript. The presence of potentially cross-reacting non-target microorganisms does not negatively impact assay results.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions

20.

RECEPTACLE TRANSPORT CARRIERS

      
Document Number 03152275
Status In Force
Filing Date 2020-08-26
Open to Public Date 2021-03-04
Grant Date 2023-01-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

A sample receptacle transporting carrier includes a base defining a recess for receiving a bottom end of the sample receptacle. The carrier also includes a plurality of resilient wire fingers affixed to and extending upward from the annular support. The fingers are configured to retain the bottom end of the sample receptacle within the recess of the base and to maintain the sample receptacle in an upright orientation. Each of the wire fingers includes a first segment adjacent to the base, a linear second segment joined to the first segment by a first angled portion, and a linear third segment joined to the second linear segment by a second angled portion. The third segment of each finger is configured to contact the bottom end of the receptacle as the receptacle is inserted into the carrier. The third segment and the vertical axis of the carrier form an angle between about 40° and about 50°.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

21.

OLIGONUCLEOTIDES FOR USE IN DETERMINING THE PRESENCE OF TRICHOMONAS VAGINALIS IN A SAMPLE

      
Document Number 03144452
Status Pending
Filing Date 2020-07-02
Open to Public Date 2021-01-07
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Johnson, Tamara Jane Angeles
  • O'Donnell, Meghan Ann
  • Jiang, Alice

Abstract

Methods for use in multiplex amplification and or detection of Trichomonas vaginalis. The multiphase amplification provides fast, quantitative, sensitive detection with lower variability at low analyte concentrations. Described are detection probes, capture probes, amplification oligonucleotides, nucleic acid compositions, probe mixes, methods, and kits useful for amplifying and determining the presence of Trichomonas vaginalis in a test sample.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6865 - Promoter-based amplification, e.g. nucleic acid sequence-based amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

22.

RECEPTACLE TRANSPORT SYSTEM FOR AN ANALYTICAL SYSTEM

      
Document Number 03137749
Status In Force
Filing Date 2020-04-29
Open to Public Date 2020-11-12
Grant Date 2023-12-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran
  • Buse, David Aaron
  • Combs, David H.

Abstract

A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first location.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

23.

RECEPTACLE TRANSPORT SYSTEM FOR AN ANALYTICAL SYSTEM

      
Document Number 03176696
Status Pending
Filing Date 2020-04-29
Open to Public Date 2020-11-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran
  • Buse, David Aaron
  • Combs, David H.

Abstract

A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first locati on.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

24.

RECEPTACLE TRANSPORT SYSTEM FOR AN ANALYTICAL SYSTEM

      
Document Number 03176699
Status Pending
Filing Date 2020-04-29
Open to Public Date 2020-11-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran
  • Buse, David Aaron
  • Combs, David H.

Abstract

A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first locati on.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

25.

SYSTEM AND METHOD FOR MANAGING LIQUID WASTE

      
Document Number 03138508
Status In Force
Filing Date 2020-04-22
Open to Public Date 2020-11-12
Grant Date 2023-08-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David H.
  • Baker, Ayra
  • Hagen, Norbert D.
  • Buse, David A.

Abstract

A system for managing liquid waste includes a first liquid container that receives waste liquid, a liquid transfer pump fluidly connected to the first liquid container; and a second liquid container fluidly connectable to the liquid transfer pump. The liquid transfer pump is can be selectively activated to transfer liquid waste from the first liquid container to the second liquid container when the second liquid container is fluidly connected to the liquid transfer pump. A method for managing liquid waste includes the steps of receiving waste liquid into a first liquid container, monitoring the amount of liquid in the first container, connecting a second liquid container to a liquid transfer pump that is connected to the first liquid container, after the amount of liquid received into the first liquid container reaches a predefined level, transferring liquid from the first liquid container into the second liquid container with the liquid transfer pump, and removing liquid transferred to the second liquid container.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
  • C02F 1/00 - Treatment of water, waste water, or sewage

26.

RECEPTACLE TRANSPORT SYSTEM FOR AN ANALYTICAL SYSTEM

      
Document Number 03176703
Status Pending
Filing Date 2020-04-29
Open to Public Date 2020-11-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Peng, Hongran
  • Buse, David Aaron
  • Combs, David H.

Abstract

A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first locati on.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

27.

SYSTEM AND METHOD FOR MANAGING LIQUID WASTE

      
Document Number 03205268
Status Pending
Filing Date 2020-04-22
Open to Public Date 2020-11-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David H.
  • Baker, Ayra
  • Hagen, Norbert D.
  • Buse, David A.

Abstract

A system for managing liquid waste includes a first liquid container that receives waste liquid, a liquid transfer pump fluidly connected to the first liquid container; and a second liquid container fluidly connectable to the liquid transfer pump. The liquid transfer pump is can be selectively activated to transfer liquid waste from the first liquid container to the second liquid container when the second liquid container is fluidly connected to the liquid transfer pump. A method for managing liquid waste includes the steps of receiving waste liquid into a first liquid container, monitoring the amount of liquid in the first container, connecting a second liquid container to a liquid transfer pump that is connected to the first liquid container, after the amount of liquid received into the first liquid container reaches a predefined level, transferring liquid from the first liquid container into the second liquid container with the liquid transfer pump, and removing liquid transferred to the second liquid container.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C02F 1/00 - Treatment of water, waste water, or sewage

28.

DISPOSABLE PIPETTE TIP MANAGEMENT

      
Document Number 03134556
Status In Force
Filing Date 2020-03-19
Open to Public Date 2020-10-08
Grant Date 2022-06-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David H.
  • Hagen, Norbert D.
  • Baker, Ayra
  • Ellis, Joseph Reed

Abstract

After disposable pipette tips are used by an automated pipettor, they are released by the pipettor and fall into a waste container. When the waste container is removed to be emptied, the pipette tips are temporarily sequestered in a pipette tip holding station so that the automated pipettor may operate uninterrupted. After the waste container is replaced, the sequestered pipette tips are released by the holding station into the waste container.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

29.

SYSTEM AND METHOD FOR TRANSPORTING AND HOLDING CONSUMABLES IN A PROCESSING INSTRUMENT

      
Document Number 03130792
Status Pending
Filing Date 2020-03-06
Open to Public Date 2020-09-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Combs, David H.
  • Buse, David A.
  • Hagen, Norbert D.
  • Opalsky, David
  • Chen, Jin

Abstract

A system and method provides a supply of consumables to a processing instrument that uses one or more of the consumables for each of a plurality of processes performed by the instrument. The system includes a loading drawer holding a carrier for receiving a plurality of consumables and an input module for holding a carrier supporting a plurality of consumables thereon and presenting the consumables for access by the instrument. A transporter includes a vertical elevator and a lateral actuator for moving a lift platform vertically and laterally and for transporting carriers on the lift platform with or without consumables supported thereon between the loading drawer and the input module, between the loading drawer and one or more holding shelves, or between the input module and one or more holding shelves. A carrier includes parallel support rails for holding multiple receptacle units and retainer tabs for retaining the units on the support rails.

IPC Classes  ?

  • B65G 47/74 - Feeding, transfer, or discharging devices of particular kinds or types
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

30.

DETECTION OF DRUG-RESISTANT MYCOPLASMA GENITALIUM

      
Document Number 03127620
Status Pending
Filing Date 2020-01-23
Open to Public Date 2020-07-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Johnson, Tamara
  • Darby, Paul M.
  • Getman, Damon K.

Abstract

Provided are methods, compositions and systems for detecting nucleic acids of macrolide-resistant Mycoplasma genitalium. In one embodiment, real time Ct values determined for a wild type sequence and for a drug resistance marker, each on an opposite strand of the same amplification product, are compared to determine the presence or absence of the drug resistance marker in nucleic acids of a test sample.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

31.

COMPOSITIONS AND METHODS FOR DETECTING PLASMODIUM SPECIES NUCLEIC ACID

      
Document Number 03123451
Status Pending
Filing Date 2019-12-20
Open to Public Date 2020-06-25
Owner
  • GEN-PROBE INCORPORATED (USA)
  • GRIFOLS DIAGNOSTIC SOLUTIONS INC. (USA)
Inventor
  • Self, Deanna
  • Linnen, Jeffrey M.
  • Bres, Vanessa

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and capture probes, for detection of Plasmodium species nucleic acid in a sample. Also disclosed are methods of specific nucleic acid amplification and detection, including amplification and detection of target nucleic acid in real time, using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa

32.

COMPOSITIONS AND METHODS FOR AMPLIFYING, DETECTING OR QUANTIFYING HUMAN POLYOMAVIRUS BK VIRUS

      
Document Number 03116895
Status Pending
Filing Date 2019-10-22
Open to Public Date 2020-04-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shah, Ankur
  • Yadav, Meghna

Abstract

Oligomer nucleotides, compositions, methods, kits, and uses are provided for detecting or quantifying a human polyomavirus BK virus (BKV) nucleic acid, e.g., using nucleic acid amplification and hybridization assays.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

33.

COMPOSITIONS AND METHODS FOR AMPLIFYING OR DETECTING VARICELLA-ZOSTER VIRUS

      
Document Number 03112342
Status Pending
Filing Date 2019-10-01
Open to Public Date 2020-04-09
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Carvallo Pinto, Marcela Alejandra
  • Hillius, Amber Jean
  • Shah, Ankur

Abstract

Disclosed are oligonucleotides, oligonucleotide compositions, kits, methods, formulations, and reaction mixtures that provide for sensitive and specific detection of a target nucleic acid sequence, or amplicon generated from a target nucleic acid sequence, of Varicella-Zoster Virus (VZV1 (if present) in a sample. The oligonucleotides, compositions, kits, methods, formulations, and reaction mixtures can be used to detect the presence of VZV in a sample. The oligonucleotides, compositions, kits, methods, formulations, and reaction mixtures can also be used to amplify specific target nucleic acid regions of VZV.

IPC Classes  ?

  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

34.

COMPOSITIONS AND METHODS FOR DETECTING BORDETELLA PERTUSSIS AND BORDETELLA PARAPERTUSSIS NUCLEIC ACID

      
Document Number 03112651
Status Pending
Filing Date 2019-09-26
Open to Public Date 2020-04-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara L.
  • Grobarczyk, Benjamin
  • Barhdadi, Samira

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Bordetella pertussis and Bordetella parapertussis nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

35.

COMPOSITIONS AND METHODS FOR AMPLIFYING, DETECTING OR QUANTIFYING HUMAN CYTOMEGALOVIRUS

      
Document Number 03107043
Status Pending
Filing Date 2019-08-21
Open to Public Date 2020-02-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Darby, Paul
  • Miick, Siobhan
  • Jackson, Jo Ann
  • Kim, Hee Cheol
  • Hillius, Amber
  • Shah, Ankur

Abstract

Oligomer nucleotides, compositions, methods, kits, and uses are provided for detecting or quantifying a Human Cytomegalovirus virus 1 (CMV (human herpesvirus 5, HHV5) nucleic acid, e.g., using nucleic acid amplification and hybridization assays. Multiphase amplification of a CMV target sequence is also described. The oligomer nucleotides, compositions, methods, kits, and uses can be used to amplify and/or detect the UL56 gene of CMV.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

36.

COMPOSITIONS AND METHODS FOR DETECTING BACTERIAL NUCLEIC ACID AND DIAGNOSING BACTERIAL VAGINOSIS

      
Document Number 03108906
Status Pending
Filing Date 2019-08-23
Open to Public Date 2020-02-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Getman, Damon Kittredge
  • Hudson, Angela Sebring
  • Pham, Jimmykim
  • Wang, Xianqun
  • Clark, Caroline

Abstract

[410] Disclosed are methods for diagnosing Bacterial Vaginosis in a subject comprising performing an assay for the detection of any one or more of Lactobacillus sp., Atopobium vaginae, and Gardneralla vaginalis in a subject sample. Also disclosed are compositions and methods for detecting Lactobacillus sp., Atopobium vaginae, and/or Gardneralla vaginalis nucleic acid in a sample.

IPC Classes  ?

  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

37.

COMPOSITIONS, METHODS AND KITS FOR DETECTING MYCOPLASMA GENITALIUM

      
Document Number 03108105
Status Pending
Filing Date 2019-08-07
Open to Public Date 2020-02-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Kirkconnell, Brett W.
  • Weinbaum, Barbara S.
  • Getman, Damon K.
  • Jiang, Alice

Abstract

The present disclosure relates to oligonucleotides useful for determining the presence of Mycoplasma genitalium in a test sample. The oligonucleotides of the present disclosure may be incorporated into hybridization assay probes, capture probes and amplification primers, and used in various combinations thereof.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/686 - Polymerase chain reaction [PCR]

38.

COMPOSITIONS AND METHODS FOR DETECTING NUCLEIC ACIDS OF EPSTEIN-BARR VIRUS

      
Document Number 03106975
Status Pending
Filing Date 2019-08-01
Open to Public Date 2020-02-06
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Shah, Ankur
  • Fung, Jian Yu

Abstract

Disclosed are compositions, methods, and kits that can be used to Epstein-Barr virus (EBV) in a sample undergoing testing. Nucleic acids of EBV can be isolated, amplified and detected with specificity by real- time PCR, and without interference from non-EBV organisms. In some embodiments, nucleic acids used for amplification are isolated from human blood, or blood products. Nucleic acid isolation, amplification and detection steps can all be carried out using an automated instrument.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

39.

METHODS AND SYSTEMS FOR DETECTING AND QUANTIFYING NUCLEIC ACIDS

      
Document Number 03105684
Status Pending
Filing Date 2019-07-10
Open to Public Date 2020-01-16
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Wang, Xianqun
  • Tuggle, James T.
  • Shah, Ankur H.

Abstract

A system, method, computer, and computer readable medium enabling a user to quantify a target nucleic acid analyte.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR

40.

SAMPLE PREPARATION METHOD AND SYSTEM

      
Document Number 03103268
Status Pending
Filing Date 2019-06-14
Open to Public Date 2020-01-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Eaton, Barbara L.
  • Shah, Ankur

Abstract

Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. A biological sample is combined with an alkaline composition that lyses cells and denatures DNA to create a first liquid composition. The first liquid composition is then mixed with a buffer, a detergent, and a solid support that captures DNA to create a second liquid composition. The buffer, detergent, and solid support can be delivered as components of a single reagent. Captured DNA strands can be used as templates in subsequently performed nucleic acid amplification and detection reactions with improved sensitivity.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

41.

METHOD AND APPARATUS FOR FREEZING DISPENSED DROPLETS OF LIQUID

      
Document Number 03101599
Status Pending
Filing Date 2019-06-14
Open to Public Date 2019-12-26
Owner GEN-PROBE INCORPORATED (USA)
Inventor Bashar, Reza

Abstract

A method and apparatus for freezing a liquid droplet includes dispensing, by a liquid dispenser (14), a droplet (13) of liquid into a fluid chamber (10) containing a freezing fluid (12). The droplet of liquid is allowed to dwell in the freezing fluid for at least a predetermined dwell time so that the droplet of liquid freezes to a frozen droplet. The method and apparatus further includes injecting, by a gas injector (17), a stream (16) of gas transversely to a surface of the freezing fluid at about where the frozen droplet is located along the surface of the freezing fluid contained in the fluid chamber so that the frozen droplet sinks in the freezing fluid.

IPC Classes  ?

  • F25D 3/11 - Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air with conveyors carrying articles to be cooled through the cooling space
  • F25C 1/00 - Producing ice

42.

COMPOSITIONS AND METHODS FOR DETECTING GROUP B STREPTOCOCCUS NUCLEIC ACID

      
Document Number 03103442
Status Pending
Filing Date 2019-08-09
Open to Public Date 2019-12-19
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara L.
  • Grobarczyk, Benjamin
  • Ozog, Yves
  • Close, Renaud
  • Franzil, Laurent

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Group B Streptococcus (GBS; Streptococcus agalactiae) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

43.

FAR-RED DYE PROBE FORMULATIONS

      
Document Number 03089277
Status Pending
Filing Date 2019-02-06
Open to Public Date 2019-08-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Aubin-Walker, Sheila
  • Majlessi, Mehrdad R.
  • Pham, Jimmykim
  • Bousquet, Joshua

Abstract

Disclosed are formulations, including both liquid and lyophilized formulations, comprising a far-red dye probe and a non-linear surfactant or foamban. Also disclosed are related methods for preparing a lyophilized far-red dye probe formulation as well as related kits and diagnostic products.

IPC Classes  ?

  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

44.

ANALYTICAL SYSTEMS AND METHODS

      
Document Number 03089078
Status Pending
Filing Date 2019-01-29
Open to Public Date 2019-08-01
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer L.
  • Shapiro, Anne-Laure
  • Rhubottom, Jason F.
  • Lio, Alberto A.
  • Scheer, Timothy J.
  • Tuggle, James T.
  • Shah, Ankur H.
  • Opalsky, David

Abstract

A system, method and computer readable medium enabling a user to specify user-defined assay parameters of an assay protocol for processing a sample and causing a computer-controlled analyzer to perform an assay in accordance with the assay protocol.

IPC Classes  ?

  • C12M 1/38 - Temperature-responsive control
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • C12Q 3/00 - Condition-responsive control processes

45.

COMPOSITIONS AND METHODS FOR DETECTING C1ORF43 NUCLEIC ACID

      
Document Number 03082909
Status In Force
Filing Date 2018-11-15
Open to Public Date 2019-05-23
Grant Date 2023-07-25
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Miick, Siobhan M.
  • Darby, Paul M.
  • Jackson, Jo Ann
  • Getman, Damon K.

Abstract

This disclosure provides oligomers, combinations of oligomers, compositions, kits, uses, and methods for detecting a C1orf43 nucleic acid, such as C1orf43 mRNA, such as human C1orf43 mRNA, in a sample.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

46.

COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS

      
Document Number 03072452
Status Pending
Filing Date 2018-08-09
Open to Public Date 2019-02-14
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick
  • Darby, Paul
  • Jost, Matthias
  • Miick, Siobhan
  • Brentnall, Matthew
  • Jackson, Joann

Abstract

Provided herein are compositions, kits, and methods for detecting methicillin-resistant Staphylococcus aureus (MRSA) nucleic acids. In some embodiments, the compositions, kits, and methods can be used to detect one or more of type i, ii, iii, iv, v, vi, vii, viii, ix, xii, xiii, xiv, xv, or xxi SCCmec right extremity junction (MREJ) MRSA nucleic acids and one or more of mecA, mecC, and/or an additional S. aureus-specific gene.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

47.

ANALYTICAL SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION USING SAMPLE ASSIGNING PARAMETERS

      
Document Number 03068994
Status In Force
Filing Date 2018-07-10
Open to Public Date 2019-01-17
Grant Date 2023-06-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer L.
  • Shapiro, Ann-Laure
  • Shah, Ankur H.
  • Tuggle, James T.
  • Opalsky, David
  • Lio, Alberto A.
  • Scheer, Timothy J.
  • Rhubottom, Jason F.
  • Buse, David Aaron

Abstract

Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system-defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

48.

ANALYTICAL SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION USING SAMPLE ASSIGNING PARAMETERS

      
Document Number 03155871
Status Pending
Filing Date 2018-07-10
Open to Public Date 2019-01-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer L.
  • Shapiro, Ann-Laure
  • Shah, Ankur H.
  • Tuggle, James T.
  • Opalsky, David
  • Lio, Alberto A.
  • Scheer, Timothy J.
  • Rhubottom, Jason F.
  • Buse, David Aaron

Abstract

Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system- defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

49.

RECEPTACLE HOLDERS, SYSTEMS, AND METHODS FOR CAPACITIVE FLUID LEVEL DETECTION

      
Document Number 03068988
Status Pending
Filing Date 2018-07-09
Open to Public Date 2019-01-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Pham, Trung Q.
  • Jeffers Ii, Jerry W.
  • Buse, David
  • Grubbs, Steven G.

Abstract

A receptacle holder for supporting at least one fluid-containing receptacle includes a body and an RFID transponder. The body includes an electrically conductive portion defining a first recess configured to receive at least a first fluid-containing receptacle, and an electrically non-conductive portion attached to the electrically conductive portion. The RFID transponder is disposed on the electrically non-conductive portion of the body, and stores information about the receptacle holder. The receptacle holder can also include the first fluid-containing receptacle received within the first recess.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • B01L 9/00 - Supporting devices; Holding devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

50.

ANALYTICAL SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION USING SAMPLE ASSIGNING PARAMETERS

      
Document Number 03155859
Status Pending
Filing Date 2018-07-10
Open to Public Date 2019-01-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer L.
  • Shapiro, Ann-Laure
  • Shah, Ankur H.
  • Tuggle, James T.
  • Opalsky, David
  • Lio, Alberto, A.
  • Scheer, Timothy J.
  • Rhubottom, Jason F.
  • Buse, David Aaron

Abstract

Systems and methods för perförming a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system- defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

51.

ANALYTICAL SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION USING SAMPLE ASSIGNING PARAMETERS

      
Document Number 03156539
Status Pending
Filing Date 2018-07-10
Open to Public Date 2019-01-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Tidd, Jennifer L.
  • Shapiro, Ann-Laure
  • Shah, Ankur H.
  • Tuggle, James T.
  • Opalsky, David
  • Lio, Alberto A.
  • Scheer, Timothy J.
  • Rhubottom, Jason F.
  • Buse, David Aaron

Abstract

Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system-defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.

IPC Classes  ?

  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

52.

DETECTING BABESIA SPECIES NUCLEIC ACID IN A SAMPLE

      
Document Number 03064603
Status Pending
Filing Date 2018-06-06
Open to Public Date 2018-12-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Bres, Vanessa
  • Self, Deanna
  • Linnen, Jeffrey M.

Abstract

There is described herein a method for specifically detecting Babesia species nucleic acid in a sample, which in one aspect comprises: (1) contacting a sample, said sample suspected of containing Babesia species nucleic acid, with at least two oligomers for amplifying a target region of a Babesia species target nucleic acid, wherein the at least two amplification oligomers comprise: (a) a first amplification oligomer comprising a first target-hybridizing sequence (i) that is from about 15 to about 33 contiguous nucleotides in length, is contained in the sequence of SEQ ID NO:66 and comprises SEQ ID NO:56 or 57; or (ii) that is from about 15 to about 33 contiguous nucleotides in length, is contained in the sequence of SEQ ID NO:96 and comprises SEQ ID NO:101; or (iii) that is from about 15 to about 33 contiguous nucleotides in length, is contained in the sequence of SEQ ID NO:97 and comprises SEQ ID NO:101; (iv) comprises or consists of SEQ ID NO:8; (v) comprises or consists of SEQ ID NO:83 and (b) a second amplification oligomer comprising a second target-hybridizing sequence that is from about 15 to about 33 contiguous nucleotides in length, and (i) is contained in SEQ ID NO:68 and comprises SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, or SEQ ID NO:85; or (ii) is contained in SEQ ID NO:67 and comprises SEQ ID NO:45 or SEQ ID NO:52;or (iii) is contained in SEQ ID NO:70 and comprises SEQ ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, or SEQ ID NO:51; (2) performing an in vitro nucleic acid amplification reaction, wherein any Babesia target nucleic acid present in said sample is used as a template for generating an amplification product; and (3) detecting the presence or absence of the amplification product, thereby indicating the presence or absence of Babesia species target nucleic acid in said sample.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

53.

DRIED COMPOSITIONS CONTAINING FLAP ENDONUCLEASE

      
Document Number 03059977
Status In Force
Filing Date 2018-05-18
Open to Public Date 2018-11-22
Grant Date 2024-02-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick
  • Luu, Tony
  • Jost, Matthias

Abstract

CA3059977 ABSTRACT This specification provides compositions used in nucleic acid based assays. There is disclosed a composition of an aqueous solution and dried compositions forms comprising, consisting or consisting essentially of a flap endonuclease, a bulking agent consisting essentially of trehalose, raffinose, or a combination thereof, an organic buffer, wherein the aqueous solution has an inorganic salt concentration of 5 mM or less and at least one oligonucleotide useful for performing a molecular assay, wherein the composition is substantially free of glycerol. Also disclosed are methods relating to preparing dried compositions for use in performing nucleic acid based assays. Kits and dialysis compositions are also disclosed. Date Recue/Date Received 2021-02-16

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 9/22 - Ribonucleases
  • C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
  • C12N 9/98 - Preparation of granular or free-flowing enzyme compositions

54.

DRIED COMPOSITIONS CONTAINING FLAP ENDONUCLEASE

      
Document Number 03224227
Status Pending
Filing Date 2018-05-18
Open to Public Date 2018-11-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick
  • Luu, Tony
  • Jost, Matthias

Abstract

There is disclosed a composition of an aqueous solution comprising, consisting or consisting essentially of a flap endonuclease, a bulking agent and an organic buffer, wherein the aqueous solution has an inorganic salt concentration of 5 mM or less and wherein the composition is substantially free of glycerol.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 9/22 - Ribonucleases
  • C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
  • C12N 9/98 - Preparation of granular or free-flowing enzyme compositions

55.

COMPOSITIONS AND METHODS FOR ISOLATING TARGET NUCLEIC ACIDS

      
Document Number 03062075
Status In Force
Filing Date 2018-05-10
Open to Public Date 2018-11-15
Grant Date 2024-04-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor Shah, Ankur

Abstract

Populations of target capture probes are provided that are useful for nucleic acid separation and purification. The probes of the population comprise a first region that is at least about 12 residues in length and comprises a poly(r) sequence comprising (i) a randomized sequence comprising G and A nucleotides, or (ii) a non-randomized repeating (A and G) sequence; and a second region comprising a first specific binding partner (SBP), wherein the SBP is capable of specifically binding a second specific binding partner (SBP2). Related combinations, methods, uses, kits, and reaction mixtures are also provided.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

56.

METHODS AND COMPOSITIONS TO DETECT METAPNEUMOVIRUS NUCLEIC ACIDS

      
Document Number 03225593
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-10-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Shah, Ankur H.
  • Hillius, Amber
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

The disclosure is related to methods, compositions, and kits for targeting Metapneumovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
  • C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof

57.

COMPOSITIONS, METHODS AND KITS TO DETECT ADENOVIRUS NUCLEIC ACIDS

      
Document Number 03056135
Status In Force
Filing Date 2018-03-23
Open to Public Date 2018-10-04
Grant Date 2024-02-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Shah, Ankur
  • Hillius, Amber
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

The disclosed disclosure is related to methods, compositions, and kits for targeting Adenovirus, Metapneumovirus, and/or Rhinovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

58.

METHODS AND COMPOSITIONS TO DETECT RHINOVIRUS NUCLEIC ACIDS

      
Document Number 03225653
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-10-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Shah, Ankur H.
  • Hillius, Amber
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

The disclosure is related to methods, compositions, and kits for targeting Rhinovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

59.

METHODS AND COMPOSITIONS TO DETECT COMBINATIONS OF VIRAL NUCLEIC ACIDS

      
Document Number 03225845
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-10-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Shah, Ankur H.
  • Hillius, Amber
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

The disclosure is related to methods, compositions, and kits for targeting combinations of viral nucleic acids, including Adenovirus nucleic acid and at least one of Metapneumovirus nucleic acid and Rhinovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

60.

COMPOSITIONS TO DETECT ADENOVIRUS NUCLEIC ACIDS

      
Document Number 03225861
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-10-04
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Shah, Ankur H.
  • Hillius, Amber
  • Douglass, Pamela
  • Kolk, Daniel

Abstract

The disclosure is related to methods, compositions, and kits for targeting Adenovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

61.

COMPOSITIONS AND METHODS FOR DETECTION OF VIRAL PATHOGENS IN SAMPLES

      
Document Number 03176517
Status In Force
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Grant Date 2024-03-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Douglass, Pamela
  • Kolk, Daniel P.
  • Majlessi, Mehrdad R.

Abstract

This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

62.

COMPOSITIONS AND METHODS FOR DETECTION OF VIRAL PATHOGENS IN SAMPLES

      
Document Number 03176529
Status In Force
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Grant Date 2024-03-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Douglass, Pamela
  • Kolk, Daniel P.
  • Majlessi, Mehrdad R.

Abstract

This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

63.

COMPOSITIONS AND METHODS FOR DETECTION OF VIRAL PATHOGENS IN SAMPLES

      
Document Number 03176536
Status In Force
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Grant Date 2024-03-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Douglass, Pamela
  • Kolk, Daniel P.
  • Majlessi, Mehrdad R.

Abstract

This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

64.

COMPOSITIONS AND METHODS FOR DETECTION OF VIRAL PATHOGENS IN SAMPLES

      
Document Number 03055427
Status In Force
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Grant Date 2022-12-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Jost, Matthias
  • Douglass, Pamela
  • Kolk, Daniel P.
  • Majlessi, Mehrdad R.

Abstract

This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

65.

SYSTEM FOR MIXING CONTENTS OF CONTAINERS AND RELATED METHODS OF USE

      
Document Number 03055989
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor Buse, David A.

Abstract

A method for mixing fluids in containers may include performing a mixing procedure on a plurality of containers (128, 130) on a container support (110), at least a portion of the plurality of containers being differently sized. The mixing procedure may include a plurality of mixing phases, wherein in each mixing phase the container support may be subjected to a mixing motion at a single rate for a period of time of about 5 seconds or longer, and wherein the single rate for at least one mixing phase of the plurality of mixing phases may differ from the single rate for at least one other mixing phase of the plurality of mixing phases. The mixing procedure also may include at least one non-mixing phase, wherein the container support may not be subjected to the mixing motion.

IPC Classes  ?

  • B01F 35/222 - Control or regulation of the position of mixing devices or elements
  • B01F 29/10 - Mixers with rotating receptacles with receptacles rotated about two different axes, e.g. receptacles having planetary motion
  • B01F 29/15 - Use of centrifuges for mixing
  • B01F 35/33 - Transmissions; Means for modifying the speed or direction of rotation

66.

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING PARAINFLUENZA VIRUS

      
Document Number 03057154
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Majlessi, Mehrdad R.
  • Douglass, Pamela
  • Kolk, Daniel P.

Abstract

Compositions, methods, kits, and uses are provided for detecting or quantifying an Human Parainfluenza virus 1 (HPIV-1), HPIV-2, HPIV-3, and/or HPIV-4 nucleic acid, e.g., using nucleic acid amplification and hybridization assays. In some embodiments, the compositions, methods, kits, and uses target the HN gene of HPIV-1, HPIV-2, and/or HPIV-3 and/or the NP gene of HPIV-4.

IPC Classes  ?

  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

67.

SYSTEMS AND METHODS FOR CAPACITIVE FLUID LEVEL DETECTION, AND HANDLING CONTAINERS

      
Document Number 03057316
Status Pending
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Opalsky, David
  • Buse, David
  • Tuggle, James T.
  • Navarro, Alex
  • Sheehan, Patrick

Abstract

A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

68.

COVER ASSEMBLY AND RELATED METHODS OF USE

      
Document Number 03057325
Status In Force
Filing Date 2018-03-23
Open to Public Date 2018-09-27
Grant Date 2024-03-12
Owner GEN-PROBE INCORPORATED (USA)
Inventor Buse, David A.

Abstract

A cover assembly may include a tray assembly frame, a first cover supported by the tray assembly frame, the first cover extending in a first plane and defining one or more first openings; a second cover supported by the tray assembly frame, the second cover extending in a second plane and defining one or more second openings, wherein the first and second planes are different planes, and wherein the second cover is disposed above the first cover. The cover assembly may include one or more tray holders, each tray holder being configured to hold at least one tray in an upright orientation, wherein each tray holder is moveable between an open position and a closed position, the tray holders being accessible for loading or removing the trays in the open position, and the tray holders being positioned beneath the first and second covers in the closed position.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

69.

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS B VIRUS

      
Document Number 03042451
Status Pending
Filing Date 2017-11-17
Open to Public Date 2018-05-24
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Linnen, Jeffrey M.

Abstract

This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

70.

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS C VIRUS

      
Document Number 03040907
Status Pending
Filing Date 2017-10-18
Open to Public Date 2018-04-26
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Miick, Siobhan
  • Darby, Paul M.
  • Jackson, Jo A.
  • Walker, Sheila

Abstract

This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis C virus (HCV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the 5' untranslated region of HCV and are configured to provide substantially equivalent quantification of different genotypes and variants of HCV.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6851 - Quantitative amplification

71.

COMPOSITIONS ON PLASMA-TREATED SURFACES

      
Document Number 03035577
Status In Force
Filing Date 2017-09-29
Open to Public Date 2018-04-05
Grant Date 2023-08-29
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Knight, Byron J.
  • Opalsky, David

Abstract

The invention pertains toa method of preparing a solid composition adhered to a plasma- treated interior surface of a vessel. The method comprises the steps of dispensing a solution comprising one or more enzymes onto the plasma-treated interior surface of the vessel, and then drying the solution on the plasma-treated interior surface to form a solid composition from the solution in the form of a lyophilized pellet adhered to the plasma-treated interior surface of the vessel. The solid composition is macroscopic in three orthogonal dimensions, such that the solid composition is not a coating and has a length, a width, and a height of greater than 1 mm.

IPC Classes  ?

  • C08J 7/06 - Coating with compositions not containing macromolecular substances
  • C08J 7/18 - Chemical modification with polymerisable compounds using wave energy or particle radiation

72.

COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID

      
Document Number 03026723
Status In Force
Filing Date 2017-06-09
Open to Public Date 2017-12-14
Grant Date 2023-03-21
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Linnen, Jeffrey M.

Abstract

Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

73.

BLOOD CELL LYSIS REAGENT

      
Document Number 03232826
Status Pending
Filing Date 2017-04-26
Open to Public Date 2017-11-02
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Chelliserry, Jijumon
  • Linnen, Jeffrey

Abstract

Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.

74.

BLOOD CELL LYSIS REAGENT

      
Document Number 03021914
Status In Force
Filing Date 2017-04-26
Open to Public Date 2017-11-02
Grant Date 2024-04-30
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Gao, Kui
  • Chelliserry, Jijumon
  • Linnen, Jeffrey

Abstract

Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

75.

DRIED AMPLIFICATION COMPOSITIONS

      
Document Number 03011617
Status Pending
Filing Date 2017-02-03
Open to Public Date 2017-08-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Filipowsky, Mark
  • Martin, Donald
  • Jost, Matthias
  • Nodelman, Vladislav
  • Dickson, Robert Stephen
  • Crowell, Cheryl Lynn
  • Mauch, Steven

Abstract

The disclosure provides dried compositions providing reagents for nucleic acid amplification, which are essentially free of inorganic salts. Lack of inorganic salts increases stability of such compositions and decreases formation of byproducts. Salts required for use of enzymes in the composition are supplied on reconstitution.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

76.

METHODS AND COMPOSITIONS FOR DETECTING CANDIDA SPECIES

      
Document Number 03010232
Status Pending
Filing Date 2017-01-04
Open to Public Date 2017-07-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hudson, Angela S.
  • Getman, Damon K.
  • Jiang, Alice
  • Eaton, Barbara L.

Abstract

Disclosed are methods utilizing specific amplification of Candida sp. target nucleic acid for detecting the presence or absence of Candida sp. in a sample. Also disclosed are corresponding oligomers, including amplification oligomers, capture probes and detection probes, and combinations thereof, as well as corresponding reaction mixtures and kits.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

77.

SYSTEMS AND METHODS FOR ANALYZING A SAMPLE AND FOR MONITORING THE PERFORMANCE OF AN OPTICAL SIGNAL DETECTOR

      
Document Number 03008891
Status In Force
Filing Date 2016-12-22
Open to Public Date 2017-07-06
Grant Date 2024-02-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Opalsky, David
  • Raghuwanshi, Srajan
  • Bui, James

Abstract

A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.

IPC Classes  ?

  • G01N 21/03 - Cuvette constructions
  • G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

78.

SYSTEMS AND METHODS FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES

      
Document Number 03001017
Status In Force
Filing Date 2016-10-24
Open to Public Date 2017-04-27
Grant Date 2023-09-26
Owner GEN-PROBE INCORPORATED (USA)
Inventor Opalsky, David

Abstract

A sample processing or assay instrument (100) includes a moveable support (112). The moveable support (112) defines a first pocket (140A) configured to receive a first object (136) having a first machine-readable mark (147). The moveable support (112) defines a second pocket (140B) configured to receive a second object (136) having a second machine-readable mark (147). The moveable support (112) also includes a first fiducial machine-readable mark (150A) and a second fiducial machine-readable mark (150B). The instrument also includes an image capture device (128) that captures a first image including the first fiducial machine-readable mark (150A) and the first machine-readable mark (147) of the first object (136). The image capture device (128) captures a second image that includes the second fiducial machine-readable mark (150B) and the second machine-readable mark (147) of the second object (136). The instrument (100) also includes a processor configured to associate information decoded from the first and second machine-readable marks (150A, 150B) with first and second locations on the moveable support (112).

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation

79.

SYSTEMS AND METHODS FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES

      
Document Number 03208145
Status Pending
Filing Date 2016-10-24
Open to Public Date 2017-04-27
Owner GEN-PROBE INCORPORATED (USA)
Inventor Opalsky, David

Abstract

A sample processing or assay instrument includes a moveable support. The moveable support defines a first pocket configured to receive a first object having a first machine-readable mark. The moveable support defines a second pocket configured to receive a second object having a second machine-readable mark. The moveable support also includes a first fiducial machine- readable mark and a second fiducial machine-readable mark. The instrument also includes an image capture device that captures a first image including the first fiducial machine-readable mark and the first machine-readable mark of the first object. The image capture device captures a second image that includes the second fiducial machine-readable mark and the second machine- readable mark of the second object. The instrument also includes a processor configured to associate information decoded from the first and second machine-readable marks with first and second locations on the moveable support.

IPC Classes  ?

  • G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation
  • G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
  • G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light

80.

AUTOMATED SAMPLE PROCESSING INSRUMENTS, SYSTEMS, PROCESSES, AND METHODS

      
Document Number 02937707
Status Pending
Filing Date 2016-07-29
Open to Public Date 2017-01-31
Owner GEN-PROBE INCORPORATED (USA)
Inventor Silbert, Rolf

Abstract

An automated instrument for processing a sample includes a first lock configured to move between a locked configuration and an unlocked configuration. The first lock is configured to be engaged with a first movable holding structure in the locked configuration to secure the first holding structure within the automated instrument. The first lock is configured to be disengaged from the first holding structure in the unlocked configuration to allow movement of the first holding structure within the automated instrument. The automated instrument also includes a robotic arm movable within the automated instrument and configured to move the first lock between the locked configuration and the unlocked configuration. The first holding structure is configured to hold a sample processing device and configured to move within the automated instrument when the first lock is in the unlocked configuration. The robotic arm can also be configured to move the sample processing device within the system.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

81.

METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES

      
Document Number 03189984
Status Pending
Filing Date 2016-06-08
Open to Public Date 2016-12-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Opalsky, David
  • Walker, George T.
  • Knight, Byron J.

Abstract

An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

82.

METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES

      
Document Number 03158992
Status In Force
Filing Date 2016-06-08
Open to Public Date 2016-12-15
Grant Date 2022-10-25
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Opalsky, David
  • Walker, George T.
  • Knight, Byron J.

Abstract

An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

IPC Classes  ?

  • G01J 1/10 - Photometry, e.g. photographic exposure meter by comparison with reference light or electric value
  • G01N 21/64 - Fluorescence; Phosphorescence

83.

METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES

      
Document Number 03170197
Status Pending
Filing Date 2016-06-08
Open to Public Date 2016-12-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Opalsky, David
  • Walker, George T.
  • Knight, Byron J.

Abstract

0082022-137D3/89951193 ABSTRACT An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer. Date Recue/Date Received 2022-08-11

IPC Classes  ?

  • G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
  • G01J 1/10 - Photometry, e.g. photographic exposure meter by comparison with reference light or electric value
  • G01N 21/11 - Filling or emptying of cuvettes
  • G01N 21/64 - Fluorescence; Phosphorescence

84.

METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES

      
Document Number 02985850
Status In Force
Filing Date 2016-06-08
Open to Public Date 2016-12-15
Grant Date 2023-07-11
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Opalsky, David
  • Walker, George T.
  • Knight, Byron J.

Abstract

An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signaldetecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

IPC Classes  ?

  • G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
  • G01N 21/64 - Fluorescence; Phosphorescence

85.

METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES

      
Document Number 03155603
Status In Force
Filing Date 2016-06-08
Open to Public Date 2016-12-15
Grant Date 2023-03-28
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Opalsky, David
  • Walker, George T.
  • Knight, Byron J..

Abstract

An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

IPC Classes  ?

  • G01J 1/10 - Photometry, e.g. photographic exposure meter by comparison with reference light or electric value
  • G01N 21/64 - Fluorescence; Phosphorescence

86.

METHOD OF POOLING BLOOD SAMPLES

      
Document Number 02983415
Status Pending
Filing Date 2016-05-12
Open to Public Date 2016-11-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Linnen, Jeffrey M.
  • Chelliserry, Jijumon

Abstract

The disclosure provides methods of pooled analysis of samples containing red blood cells, such as whole blood cell samples. The methods are particularly useful for screening whole blood samples collected from many individuals to be used for transfusions and the like. Aliquots of such samples are individually contacted with a lysis reagent, further described below, before pooling to lyse red blood cells in the samples. After pooling, the lysates, the combined lysate is tested for presence of target(s) characteristic of pathogen(s). The method are particularly useful for identifying pathogens of red blood cells, but can also be used to run a complete panel of testing including for all of the typical targets.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12N 1/06 - Lysis of microorganisms
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

87.

MULTIPLEX INVASIVE CLEAVAGE ASSAYS

      
Document Number 02983740
Status In Force
Filing Date 2016-05-02
Open to Public Date 2016-11-10
Grant Date 2021-04-20
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Peterson, Patrick L.
  • King, Joe
  • Hall, Jeff

Abstract

The present disclosure relates to compositions and methods, and related systems, products and kits, for performing temperature-dependent multiplex invasive cleavage assays, where a plurality of target nucleic acids are detected and distinguished from each other in a procedure using only a single fluorescent moiety as the reporter, and single channel fluorescence detection. In some embodiments, at least one of the plurality of target nucleic acids is an amplified nucleic acid, where progress in a thermal cycling amplification reaction is monitored as a function of time (i.e., real-time amplification).

IPC Classes  ?

  • C12Q 1/6813 - Hybridisation assays
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

88.

SAMPLE TESTING SYSTEMS AND METHODS WITH AUTOMATED CLEANING

      
Document Number 02980595
Status In Force
Filing Date 2016-04-08
Open to Public Date 2016-10-13
Grant Date 2020-09-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert D.
  • Knight, Byron J.
  • Opalsky, David

Abstract

A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B08B 9/00 - Cleaning hollow articles by methods or apparatus specially adapted thereto
  • B08B 11/00 - Cleaning flexible or delicate articles by methods or apparatus specially adapted thereto
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • G01N 21/15 - Preventing contamination of the components of the optical system or obstruction of the light path
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

89.

SYSTEMS AND METHODS FOR READING MACHINE-READABLE LABELS ON SAMPLE RECEPTACLES

      
Document Number 02979609
Status In Force
Filing Date 2016-04-06
Open to Public Date 2016-10-13
Grant Date 2023-08-29
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert
  • Opalsky, David
  • Silbert, Rolf

Abstract

Systems for reading machine-readable labels, for example, two-dimensional barcodes, include a housing, a reader configured to read the machine-readable labels on sample receptacles as a sample rack holding the sample receptacles move between a first position and a second position within the housing. The system includes a processing and control unit configured to decode a read image of the machine-readable labels on each sample receptacle, and configured to associate a decoded read images with the corresponding sample receptacles based on measured positions of the sample rack when the machine-readable label was read.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

90.

SYSTEMS AND METHODS FOR READING MACHINE-READABLE LABELS ON SAMPLE RECEPTACLES

      
Document Number 03205046
Status Pending
Filing Date 2016-04-06
Open to Public Date 2016-10-13
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Hagen, Norbert
  • Opalsky, David
  • Silbert, Rolf

Abstract

Systems for reading machine-readable labels, for example, two-dimensional barcodes, include a housing, a reader configured to read the machine-readable labels on sample receptacles as a sample rack holding the sample receptacles move between a first position and a second position within the housing. The system includes a processing and control unit configured to decode a read image of the machine-readable labels on each sample receptacle, and configured to associate a decoded read images with the corresponding sample receptacles based on measured positions of the sample rack when the machine-readable label was read.

IPC Classes  ?

  • G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G06K 7/015 - Aligning or centring of the sensing device with respect to the record carrier
  • G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light

91.

METHODS AND COMPOSITIONS FOR DETECTING BACTERIAL NUCLEIC ACID AND DIAGNOSING BACTERIAL VAGINOSIS

      
Document Number 02977821
Status Pending
Filing Date 2016-03-16
Open to Public Date 2016-09-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Eaton, Barbara L.
  • Getman, Damon K.
  • Pawlowski, Traci

Abstract

Disclosed are methods for diagnosing Bacterial Vaginosis in a subject comprising performing an assay for the detection of any one or more of Lactobacillus sp., Gardneralla vaginalis, and Eggerthella sp. in a subject sample. Also disclosed are methods and compositions for detecting Lactobacillus sp., Gardneralla vaginalis, and/or Eggerthella nucleic acid in a sample.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins

92.

METHODS AND COMPOSITIONS FOR DIAGNOSING BACTERIAL VAGINOSIS

      
Document Number 02972475
Status In Force
Filing Date 2016-01-08
Open to Public Date 2016-07-14
Grant Date 2024-01-16
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Graham, Michael
  • Hall, Jeff G.
  • King, Joseph J.

Abstract

Disclosed are methods for diagnosing Bacterial Vaginosis (BV). The disclosed methods generally include detecting select species of Eggerthella and/or Prevotella, and optionally detecting select species of Lactobacillus. Also disclosed are nucleic acid oligomers and related compositions for detection of a 16S rRNA or its encoding gene from select species of Eggerthella, Prevotella, or Lactobacillus.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
  • C12Q 1/683 - Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor

93.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

      
Document Number 03047440
Status In Force
Filing Date 2015-10-21
Open to Public Date 2016-04-28
Grant Date 2020-12-15
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Rosati, Robert
  • Buse, David
  • Tammer, Olev
  • Merten, Matthias

Abstract

A method for controlling a printing process by which a print head prints an image onto a label affixed to a tube positioned adjacent to the print head and adjacent to a sensor configured to detect optical and/or physical features of the label, the method comprising: (a) transmitting a command to the sensor to detect the presence of the label affixed to the tube, wherein the sensor either: (1) fails to generate a signal indicating the presence of the label, or (2) generates a signal indicating the presence of the label; (b) if the sensor generates a signal indicating the presence of the label in step (a), then transmitting a command to the sensor to detect a position of a timing mark on the label, wherein the sensor fails to generate a signal indicating the position of a timing mark on the label; and (c) if the sensor fails to generate a signal indicating the presence of the label in step (a) or the sensor fails to generate a signal indicating the position of a timing mark on the label in step (b), then selectively activating the print head while effecting relative movement between the print head and the label to print multiple alternate images at multiple positions on the label.

IPC Classes  ?

  • B41F 17/22 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on filamentary or elongated articles or material, or on articles with cylindrical surfaces on articles of finite length on articles of uniform cross-section, e.g. pencils, rulers, resistors by rolling contact
  • G09F 3/00 - Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps

94.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

      
Document Number 03047441
Status In Force
Filing Date 2015-10-21
Open to Public Date 2016-04-28
Grant Date 2022-03-22
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Rosati, Robert
  • Buse, David
  • Tammer, Olev
  • Merten, Matthias

Abstract

A method for controlling a printing process by which a print head prints an image onto predetermined printable area of a label, the method comprising: (a) effecting relative movement between a timing mark sensor and the label; (b) during step (a), detecting a position of a timing mark with the timing mark sensor; (c) after step (b), effecting relative movement between the print head and the label to position the print head at an image position at a specified distance from the position of the timing mark detected in step (b); (d) activating the print head; and (e) during step (d) effecting relative movement between the print head and the label for a specified image distance to print the image onto the printable area.

IPC Classes  ?

  • B41F 17/22 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on filamentary or elongated articles or material, or on articles with cylindrical surfaces on articles of finite length on articles of uniform cross-section, e.g. pencils, rulers, resistors by rolling contact
  • G09F 3/00 - Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps

95.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

      
Document Number 03148616
Status In Force
Filing Date 2015-10-21
Open to Public Date 2016-04-28
Grant Date 2023-01-03
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David
  • Merten, Matthias
  • Rosati, Robert
  • Silbert, Rolf
  • Tammer, Olev

Abstract

A method for controlling a printing process by which a print head prints an image onto predetermined printable area of a label, the method comprising: (a) effecting relative movement between a timing mark sensor and the label; (b) during step (a), detecting a position of a timing mark with the timing mark sensor; (c) after step (b), effecting relative movement between the print head and the label to position the print head at an image position at a specified distance from the position of the timing mark detected in step (b); (d) activating the print head; and (e) during step (d) effecting relative movement between the print head and the label for a specified image distance to print the image onto the printable area.

IPC Classes  ?

  • B41F 17/22 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on filamentary or elongated articles or material, or on articles with cylindrical surfaces on articles of finite length on articles of uniform cross-section, e.g. pencils, rulers, resistors by rolling contact
  • G09F 3/00 - Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps

96.

RED BLOOD CELL LYSIS SOLUTION

      
Document Number 02962956
Status In Force
Filing Date 2015-10-20
Open to Public Date 2016-04-28
Grant Date 2023-09-05
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Chelliserry, Jijumon
  • Gao, Kui
  • Linnen, Jeffrey M.

Abstract

The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anticoagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

IPC Classes  ?

  • C12N 1/04 - Preserving or maintaining viable microorganisms
  • C12N 5/078 - Cells from blood or from the immune system
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12N 1/10 - Protozoa; Culture media therefor
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 3/50 - Investigating hardness or rebound hardness by measuring rolling friction, e.g. by rocking pendulum

97.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

      
Document Number 02964930
Status In Force
Filing Date 2015-10-21
Open to Public Date 2016-04-28
Grant Date 2018-07-10
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Rosati, Robert
  • Buse, David
  • Tammer, Olev
  • Merten, Matthias

Abstract

A printing module (10) configured to print a label on a curved surface of an article (12) includes an expandable printing mechanism (50) configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head (152) and an article moving assembly (260) configured to grasp and hold the article and effect relative movement between the curved surface and the print head (152). The printing mechanism includes contact elements, such as rollers (72,74), that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head (152) during relative movement between the curved surface and the print head (152).

IPC Classes  ?

  • B41J 3/407 - Typewriters or selective printing or marking mechanisms characterised by the purpose for which they are constructed for marking on special material
  • B41J 2/32 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by selective application of heat to a heat sensitive printing or impression-transfer material using thermal heads

98.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

      
Document Number 03006133
Status In Force
Filing Date 2015-10-21
Open to Public Date 2016-04-28
Grant Date 2019-10-01
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Silbert, Rolf
  • Rosati, Robert
  • Buse, David
  • Tammer, Olev
  • Merten, Matthias

Abstract

A method for printing on a curved surface of an article with a printing module configured to receive an article having a curved surface, secure the article so that the curved surface is in an operative position with respect to a print head of the printing module, effect relative movement between the curved surface and the print head while the print head is activated and while maintaining the curved surface in the operative position with respect to the print head, thereby printing information onto the curved surface, and then release the article so that it may be removed from the printing module.

IPC Classes  ?

  • B41F 17/08 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on filamentary or elongated articles or material, or on articles with cylindrical surfaces
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G06K 1/12 - Methods or arrangements for marking the record carrier in digital fashion otherwise than by punching
  • A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes - Details; Accessories therefor

99.

APPARATUS FOR INDEXING AND AGITATING FLUID CONTAINERS

      
Document Number 02912966
Status In Force
Filing Date 2014-03-14
Open to Public Date 2015-11-23
Grant Date 2016-07-19
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Buse, David Aaron
  • Knight, Byron J.

Abstract

An evaporation-limiting insert for a container is provided. The container includes: a hollow tubular body configured to extend into a container from an opening of the container and having an upper end portion; a retainer feature at the upper end portion of the tubular body and configured to engage a portion of the container to secure the insert within the container, wherein the tubular body includes a plurality of holes formed through a wall of the tubular body and distributed along at least a portion of the length of the body to permit fluid to flow through a space inside the tubular body, and wherein at least a portion of the holes are located below a midpoint of the tubular body. A method for mixing the fluid contents of a container while retarding evaporation of the fluid contents from the container is also provided. The method includes: providing an evaporation-limiting insert within the container, the evaporation-limiting insert comprising a hollow tubular body configured to extend into the container from an opening of the container, the tubular body including a plurality of holes formed through a wall of the tubular body and distributed along at least a portion of the length of the body; and agitating the fluid contents of the container to promote mixing of the fluid contents, whereby the holes formed through the wall of the tubular body of the insert permit fluid to flow through a space inside the tubular body.

100.

METHOD OF ISOLATING NUCLEIC ACID FROM SPECIMENS IN LIQUID-BASED CYTOLOGY PRESERVATIVES CONTAINING FORMALDEHYDE

      
Document Number 02940591
Status In Force
Filing Date 2014-03-21
Open to Public Date 2015-09-03
Grant Date 2020-11-17
Owner GEN-PROBE INCORPORATED (USA)
Inventor
  • Kirkconnell, Brett Wolfe
  • Wilson, Timothy Joseph
  • Jensen, Deborah Christine

Abstract

Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved m a liquid-based cytology preservative that contains formaldehyde The technique relies on the use of 2-imidazolidone and a protease enzyme, such as protemase K, at elevated temperatures Advantageously, RNA can be isolated and used as a template in nucleic acid amplification reactions

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12M 1/38 - Temperature-responsive control
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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