Abbott Point Of Care Inc.

United States of America

Back to Profile

1-100 of 149 for Abbott Point Of Care Inc. Sort by
Query
Patent
United States - USPTO
Aggregations Reset Report
Date
2024 March 1
2024 (YTD) 1
2023 1
2022 4
2021 8
See more
IPC Class
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 55
G01N 33/49 - Physical analysis of biological material of liquid biological material blood 29
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals 29
G01N 27/327 - Biochemical electrodes 23
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers 20
See more
Status
Pending 9
Registered / In Force 140
Found results for  patents
  1     2        Next Page

1.

APPARATUS AND DEVICES FOR PROCESSING FLUID SAMPLES

      
Application Number 18516026
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-03-14
Owner Abbott Point of care Inc. (USA)
Inventor Virtanen, Antti

Abstract

Disclosed herein is an apparatus for processing fluid samples such as blood or blood products. Also disclosed are devices comprising the apparatus as well as methods for separating plasma from blood or blood products using said apparatus.

IPC Classes  ?

  • G01N 1/34 - Purifying; Cleaning
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

2.

Management system for point of care testing

      
Application Number 17951771
Grant Number 11995598
Status In Force
Filing Date 2022-09-23
First Publication Date 2023-03-16
Grant Date 2024-05-28
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann
  • Emeric, Pierre
  • Molloy, Dan
  • Weber, Maureen
  • Fetters, Christopher

Abstract

The present invention relates to a method and system for quality compliance, system and operator verification, and process management for point of care biological sample testing systems used in hospitals and other medical delivery environments. Specifically, the present invention may be directed to a computing device configured to generate a plurality of attributes configured to assess a competency level of an operator to operate at least one sample testing instrument, obtain operator derived data pertaining to the operator's ability to operate the at least one sample testing instrument, and determine a competency level of the operator for the at least one sample testing instrument based the plurality of attributes and the operator derived data.

IPC Classes  ?

  • G06Q 10/0639 - Performance analysis of employees; Performance analysis of enterprise or organisation operations
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06Q 30/018 - Certifying business or products
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
  • G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
  • G16Z 99/00 - Subject matter not provided for in other main groups of this subclass

3.

MAGNETIC IMMUNOSENSOR WITH TRENCH CONFIGURATION AND METHOD OF USE

      
Application Number 17804330
Status Pending
Filing Date 2022-05-27
First Publication Date 2022-10-13
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Campbell, John Lewis Emerson
  • Miller, Cary James

Abstract

The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 27/327 - Biochemical electrodes
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

4.

DEVICES, SYSTEMS, AND METHODS FOR PERFORMING OPTICAL ASSAYS

      
Application Number 17645797
Status Pending
Filing Date 2021-12-23
First Publication Date 2022-04-14
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Low, Michael Louie
  • Bass, Barry
  • Gershtein, Sergey

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

IPC Classes  ?

  • G01N 21/03 - Cuvette constructions
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

5.

EXTENDED RANGE IMMUNOASSAY DEVICES WITH IMMUNOSENSOR AND MAGNETIC IMMUNOSENSOR

      
Application Number 17451029
Status Pending
Filing Date 2021-10-15
First Publication Date 2022-02-03
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antii Leo Oskari
  • Bezaire, John Wilfrid
  • Potter, Eric Edward
  • Smith, James T.K.
  • Miller, Cary James
  • Campbell, John Lewis Emerson
  • Moss, Adam Roger

Abstract

The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a housing, a heterogeneous surface capture immunosensor within the housing and configured to generate a first signal indicative of the concentration of the analyte in an upper concentration range, and a homogeneous magnetic bead capture immunosensor within the housing and configured to generate a second signal indicative of the concentration of the analyte in a lower concentration range.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 27/327 - Biochemical electrodes
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/536 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

6.

MICROFABRICATED DEVICE WITH MICRO-ENVIRONMENT SENSORS FOR ASSAYING COAGULATION IN FLUID SAMPLES

      
Application Number 17475570
Status Pending
Filing Date 2021-09-15
First Publication Date 2022-01-06
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zhao, Tian-Xian
  • Wong, Anjulia Chiu-Yuk
  • Martin, Glenn Brian
  • Di Tullio, Katrina Petronilla
  • Thibodeau, Isabelle Louisette
  • Breeze, Steven Roy
  • Sutrala, Smitha Rk
  • Hong, Eric
  • Taylor, Jay Kendall
  • Ball, Sheila Diane

Abstract

The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.

IPC Classes  ?

  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 27/403 - Cells and electrode assemblies
  • G01N 27/416 - Systems

7.

TECHNIQUES FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS WITH UNIVERSAL CIRCUITRY

      
Application Number 17350426
Status Pending
Filing Date 2021-06-17
First Publication Date 2021-10-07
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Low, Michael Louie
  • Bass, Barry
  • Gershtein, Sergey

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
  • G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers

8.

Devices, systems, and methods for performing optical and electrochemical assays

      
Application Number 17343056
Grant Number 12038403
Status In Force
Filing Date 2021-06-09
First Publication Date 2021-09-23
Grant Date 2024-07-16
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Low, Michael Louie
  • Bass, Barry
  • Gershtein, Sergey

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

IPC Classes  ?

  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 27/327 - Biochemical electrodes

9.

Methods for assuring quality compliance of point-of-care instruments used with single-use testing devices

      
Application Number 17225723
Grant Number 11994526
Status In Force
Filing Date 2021-04-08
First Publication Date 2021-08-05
Grant Date 2024-05-28
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann

Abstract

The present invention relates to systems and methods of determining quality compliance for one or more biological sample testing instruments used with one or more type of single-use blood testing cartridge, at the point-of-care in a hospital, or other location that deliver medical care. In particular, the systems and methods ensure that only instruments that pass a quality assurance protocol are used for point-of-care testing.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades

10.

Management system for point of care testing

      
Application Number 17164990
Grant Number 11488088
Status In Force
Filing Date 2021-02-02
First Publication Date 2021-06-17
Grant Date 2022-11-01
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann
  • Emeric, Pierre
  • Molloy, Dan
  • Weber, Maureen
  • Fetters, Christopher

Abstract

The present invention relates to a method and system for quality compliance, system and operator verification, and process management for point of care biological sample testing systems used in hospitals and other medical delivery environments. Specifically, the present invention may be directed to a computing device configured to generate a plurality of attributes configured to assess a competency level of an operator to operate at least one sample testing instrument, obtain operator derived data pertaining to the operator's ability to operate the at least one sample testing instrument, and determine a competency level of the operator for the at least one sample testing instrument based the plurality of attributes and the operator derived data.

IPC Classes  ?

  • G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
  • G06Q 30/00 - Commerce
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
  • G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G16Z 99/00 - Subject matter not provided for in other main groups of this subclass

11.

PORTABLE CLINICAL ANALYSIS SYSTEM FOR IMMUNOMETRIC MEASUREMENT

      
Application Number 17164996
Status Pending
Filing Date 2021-02-02
First Publication Date 2021-06-03
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Miller, Cary

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

12.

THERMAL CONTROL SYSTEM FOR CONTROLLING THE TEMPERATURE OF A FLUID

      
Application Number 17166215
Status Pending
Filing Date 2021-02-03
First Publication Date 2021-06-03
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary J.
  • Gershtein, Sergey
  • Tilson, Mitchell
  • Patel, Jaymin
  • Schneider, Craig H.
  • Hunter, Seth
  • Wasserman, Paul
  • Emeric, Pierre

Abstract

The invention relates to a thermal control system for controlling the temperature of a fluid. In particular, the invention relates to a control system having at least two heating elements, at least one of which is used for directly or indirectly heating a fluid, and at least one of which is used for heating a thermal probe used to determine the temperature of the fluid. The heating systems are controlled by at least one feedback controller.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • G05D 23/30 - Automatic controllers with an auxiliary heating device affecting the sensing element, e.g. for anticipating change of temperature

13.

Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity

      
Application Number 17165282
Grant Number 12025614
Status In Force
Filing Date 2021-02-02
First Publication Date 2021-05-27
Grant Date 2024-07-02
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Miller, Cary James

Abstract

The present invention relates to methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a method includes forming, in a biological sample, a first complex of signal antibodies and analyte, and a second complex of the first complex and capture antibodies immobilized on magnetic beads, and contacting a first immunosensor with the biological sample to form a third complex localized on or near a surface of the first immunosensor. The first immunosensor includes an immobilized layer of capture antibodies configured to bind to the analyte, and the third complex includes the first complex bound to the immobilized layer of capture antibodies. The method further includes contacting a magnetic field localized around a second immunosensor with the biological sample such that the second complex is localized on or near a surface of the second immunosensor.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
  • G01N 33/539 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

14.

Combined immunoassay and magnetic immunoassay systems and devices for extended range of sensitivity

      
Application Number 17149319
Grant Number 11680944
Status In Force
Filing Date 2021-01-14
First Publication Date 2021-05-06
Grant Date 2023-06-20
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Miller, Cary James
  • Hardage, Kenneth Harold

Abstract

The present invention relates to systems that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device is provided for detecting an analyte in a biological sample. The device includes a first electrochemical sensor positioned on a substrate. The first electrochemical sensor includes an immobilized layer of antibody configured to bind to the analyte. The device further includes a second electrochemical sensor positioned adjacent to the first electrochemical sensor on the substrate, and a magnetic material that generates a magnetic field aligned with respect to the second electrochemical sensor. The magnetic field captures magnetic beads that have an immobilized layer of antibody configured to bind to the analyte, and concentrates the magnetic beads on or near a surface of the second electrochemical sensor.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/549 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C08L 79/08 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
  • C01G 53/00 - Compounds of nickel
  • C08L 29/04 - Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
  • G01N 27/327 - Biochemical electrodes
  • C01F 17/30 - Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6

15.

Methods for assuring quality compliance of point-of-care single-use testing devices

      
Application Number 16725395
Grant Number 11249097
Status In Force
Filing Date 2019-12-23
First Publication Date 2020-04-30
Grant Date 2022-02-15
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann

Abstract

The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16Z 99/00 - Subject matter not provided for in other main groups of this subclass

16.

DUAL RANGE CARDIAC TROPONIN IMMUNOASSAY DEVICES AND METHODS USING IMMUNOSENSOR AND MAGNETIC IMMUNOSENSOR

      
Application Number 16679470
Status Pending
Filing Date 2019-11-11
First Publication Date 2020-03-05
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Potter, Eric Edward
  • Smith, James T.K.
  • Miller, Cary James
  • Campbell, John Lewis Emerson
  • Moss, Adam Roger

Abstract

The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first immunosensor including an immobilized layer of capture antibodies configured to bind to a first complex of signal antibodies and cardiac troponin such that a second complex of the first complex and the immobilized layer of capture antibodies is localized on or near the first immunosensor. The device further includes a second immunosensor having a magnetic field disposed locally around the second immunosensor. The magnetic field is configured to attract magnetic beads such that a third complex of the first complex and capture antibodies immobilized on the magnetic beads is localized on or near the second immunosensor sensor.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
  • G01N 33/539 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent

17.

Cartridge device with bypass channel for mitigating drift of fluid samples

      
Application Number 16426473
Grant Number 11198123
Status In Force
Filing Date 2019-05-30
First Publication Date 2020-01-02
Grant Date 2021-12-14
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Sabourin, David
  • Villeneuve, Alain
  • Hendry, Bruce
  • Chung, Jessica
  • Garrett, Graham E.
  • Govindaraj, Vinoth Kumar
  • Di Tullio, Katrina Petronilla
  • Ball, Sheila Diane

Abstract

The present disclosure relates to analytical testing devices comprising microfluidics and methods for performing an assay on a fluid sample received within the microfluidics, and in particular, to mitigating drift of fluid samples over a sensor by incorporating a bypass channel into the microfluidics. For example, a test cartridge device is provided that includes a fluid sample entry port and holding chamber connected to a bifurcation junction of a sensor channel and a bypass channel. The sensor channel includes an upstream region and a downstream region, and an analyte sensor is in the upstream region. As a cross-sectional area of the bypass channel is greater than the cross-sectional area of the downstream region of the sensor channel, the bypass channel is a preferred path for excess sample flow and pressure, and thus sample drift above the analyte sensor is mitigated.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

18.

Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion

      
Application Number 16551151
Grant Number 11583851
Status In Force
Filing Date 2019-08-26
First Publication Date 2019-12-12
Grant Date 2023-02-21
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Verrant, John A.
  • Lalpuria, Niten V.
  • Nikonorov, Igor
  • Unfricht, Darryn W.
  • Ports, Benjamin
  • Wardlaw, Stephen C.
  • Levine, Robert A.
  • Holt, Robert
  • Hukari, Kyle

Abstract

A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

19.

Integrated cartridge housings for sample analysis

      
Application Number 16526275
Grant Number 10828642
Status In Force
Filing Date 2019-07-30
First Publication Date 2019-11-21
Grant Date 2020-11-10
Owner ABBOTT POINT OF CARE INC. (USA)
Inventor
  • Doyle, Kevin John
  • Wilkins, Paul
  • Withers, Mick
  • Cooper, Adrian
  • Noell, John Oakey

Abstract

The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

20.

Method and apparatus for automated whole blood sample analyses from microscopy images

      
Application Number 16524422
Grant Number 10677711
Status In Force
Filing Date 2019-07-29
First Publication Date 2019-11-14
Grant Date 2020-06-09
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Herzog, David
  • Wang, Zhizhou
  • Wardlaw, Stephen C.
  • Xie, Min

Abstract

An apparatus and a method for identifying at least one type of white blood cell (WBC) within a whole blood sample is provided. The method includes: adding at least one colorant to the sample; providing at least one fluorescent excitation light and at least one transmission light; receiving both light fluorescing from and transmitted through the sample and producing signals representative thereof; creating at least one image of the sample using the signals; identifying WBCs within the sample image; quantitatively analyzing at least some of the identified WBCs within the image, including determining one or more quantitative values; and identifying at least one type of WBC from the identified WBCs using the quantitative values.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • G01N 21/03 - Cuvette constructions
  • G01N 15/14 - Electro-optical investigation
  • G01N 21/59 - Transmissivity
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

21.

Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples

      
Application Number 16259500
Grant Number 11156620
Status In Force
Filing Date 2019-01-28
First Publication Date 2019-05-23
Grant Date 2021-10-26
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zhao, Tian-Xian
  • Wong, Anjulia Chiu-Yuk
  • Martin, Glenn Brian
  • Di Tullio, Katrina Petronilla
  • Thibodeau, Isabelle Louisette
  • Breeze, Steven Roy
  • Sutrala, Smitha R K
  • Hong, Eric
  • Taylor, Jay Kendall
  • Ball, Sheila Diane

Abstract

The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.

IPC Classes  ?

  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 27/403 - Cells and electrode assemblies
  • G01N 27/416 - Systems
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

22.

Techniques for performing optical and electrochemical assays with universal circuitry

      
Application Number 16104204
Grant Number 11060994
Status In Force
Filing Date 2018-08-17
First Publication Date 2019-02-21
Grant Date 2021-07-13
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Low, Michael Louie
  • Bass, Barry
  • Gershtein, Sergey

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
  • G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 27/07 - Construction of measuring vessels; Electrodes therefor
  • G01N 27/416 - Systems

23.

Devices, systems, and methods for performing optical assays

      
Application Number 16104232
Grant Number 11253852
Status In Force
Filing Date 2018-08-17
First Publication Date 2019-02-21
Grant Date 2022-02-22
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Low, Michael Louie
  • Bass, Barry
  • Gershtein, Sergey

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 27/327 - Biochemical electrodes
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 27/416 - Systems
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

24.

Devices, systems, and methods for performing optical and electrochemical assays

      
Application Number 16104213
Grant Number 11067526
Status In Force
Filing Date 2018-08-17
First Publication Date 2019-02-21
Grant Date 2021-07-20
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Low, Michael Louie
  • Bass, Barry
  • Gershtein, Sergey

Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

IPC Classes  ?

  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
  • G01N 27/327 - Biochemical electrodes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

25.

Method for imaging biologic fluid samples using a predetermined distribution

      
Application Number 16102036
Grant Number 10627390
Status In Force
Filing Date 2018-08-13
First Publication Date 2018-12-06
Grant Date 2020-04-21
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Xie, Min
  • Wardlaw, Stephen C.

Abstract

A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • G01N 15/02 - Investigating particle size or size distribution
  • G01N 15/14 - Electro-optical investigation
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
  • G01N 33/483 - Physical analysis of biological material

26.

Optical assay device with pneumatic sample actuation

      
Application Number 16047249
Grant Number 10852299
Status In Force
Filing Date 2018-07-27
First Publication Date 2018-11-29
Grant Date 2020-12-01
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Davis, Graham
  • Ewart, Thomas
  • Gershtein, Sergey

Abstract

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to test devices, e.g., cartridges, methods and systems, wherein the test devices have an entry port configured to receive a test sample into a holding chamber; a first conduit having at least one lateral flow test strip; and a displacement device, such as a pneumatic pump, configured to move a portion of said test sample from said holding chamber into said first conduit. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/76 - Human chorionic gonadotropin

27.

Cartridge device with fluidic junctions for coagulation assays in fluid samples

      
Application Number 16035102
Grant Number 11391747
Status In Force
Filing Date 2018-07-13
First Publication Date 2018-11-08
Grant Date 2022-07-19
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Di Tullio, Katrina Petronilla
  • Taylor, Jay Kendall
  • Lee-Yow, Niko Daniel
  • Ball, Sheila Diane
  • Campbell, John Lewis Emerson

Abstract

The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 27/416 - Systems

28.

Operation and verification of a portable clinical analysis system

      
Application Number 15953671
Grant Number 10877019
Status In Force
Filing Date 2018-04-16
First Publication Date 2018-08-23
Grant Date 2020-12-29
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Fetters, Christopher

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 27/327 - Biochemical electrodes

29.

Magnetic immunosensor and method of use

      
Application Number 15938141
Grant Number 10145843
Status In Force
Filing Date 2018-03-28
First Publication Date 2018-08-02
Grant Date 2018-12-04
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Hu, Jinghua

Abstract

The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

30.

Ellagic acid formulations for use in coagulation assays

      
Application Number 15912967
Grant Number 10746749
Status In Force
Filing Date 2018-03-06
First Publication Date 2018-07-12
Grant Date 2020-08-18
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Collier, Gordon Bruce
  • Johns, Paul Willis
  • Sutrala, Smitha R K
  • Wang, Dan
  • Di Tullio, Katrina Petronilla

Abstract

The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time

31.

Portable clinical analysis system for hematocrit measurement

      
Application Number 15908202
Grant Number 10188327
Status In Force
Filing Date 2018-02-28
First Publication Date 2018-07-05
Grant Date 2019-01-29
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Zhao, Tian-Xian
  • Glavina, Paul

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 27/327 - Biochemical electrodes

32.

Extended range immunoassay devices with immunosensor and magnetic immunosensor

      
Application Number 15836216
Grant Number 11156607
Status In Force
Filing Date 2017-12-08
First Publication Date 2018-06-14
Grant Date 2021-10-26
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Bezaire, John Wilfrid
  • Potter, Eric Edward
  • Smith, James T. K.
  • Miller, Cary James
  • Campbell, John Lewis Emerson
  • Moss, Adam Roger

Abstract

The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a housing, a heterogeneous surface capture immunosensor within the housing and configured to generate a first signal indicative of the concentration of the analyte in an upper concentration range, and a homogeneous magnetic bead capture immunosensor within the housing and configured to generate a second signal indicative of the concentration of the analyte in a lower concentration range.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/536 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
  • G01N 27/327 - Biochemical electrodes
  • G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids

33.

Ameliorated crosstalk immunoassay test device for determining a concentration of an analyte

      
Application Number 15836335
Grant Number 10935511
Status In Force
Filing Date 2017-12-08
First Publication Date 2018-06-14
Grant Date 2021-03-02
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Virtanen, Antti Leo Oskari
  • Miller, Cary James
  • Hardage, Kenneth Harold

Abstract

The present invention relates to systems that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first electrochemical sensor positioned within a conduit adjacent to a second electrochemical sensor and spaced apart from one another at a predetermined distance. The first electrochemical sensor includes an immobilized layer of antibodies. The second electrochemical sensor includes a magnetic field disposed locally around the second electrochemical sensor, and the magnetic field is configured to attract magnetic beads onto a surface of the second electrochemical sensor. The device further includes a scavenging electrode positioned between the first electrochemical sensor and the second electrochemical sensor. The scavenging electrode is configured to prevent crosstalk between the first electrochemical immunosensor and the second electrical immunosensor.

IPC Classes  ?

  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
  • G01N 27/327 - Biochemical electrodes
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

34.

Sensors for assaying coagulation in fluid samples

      
Application Number 15879714
Grant Number 10352951
Status In Force
Filing Date 2018-01-25
First Publication Date 2018-06-14
Grant Date 2019-07-16
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zhao, Tian-Xian
  • Wong, Anjulia Chiu-Yuk
  • Martin, Glenn Brian
  • Di Tullio, Katrina Petronilla
  • Thibodeau, Isabelle Louisette
  • Breeze, Steven Roy
  • Sutrala, Smitha R K
  • Hong, Eric
  • Ball, Sheila Diane

Abstract

The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time

35.

Combined immunoassay and magnetic immunoassay systems and devices for extended range of sensitivity

      
Application Number 15835972
Grant Number 10908154
Status In Force
Filing Date 2017-12-08
First Publication Date 2018-06-14
Grant Date 2021-02-02
Owner Abbottt Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Miller, Cary James
  • Hardage, Kenneth Harold

Abstract

The present invention relates to systems that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device is provided for detecting an analyte in a biological sample. The device includes a first electrochemical sensor positioned on a substrate. The first electrochemical sensor includes an immobilized layer of antibody configured to bind to the analyte. The device further includes a second electrochemical sensor positioned adjacent to the first electrochemical sensor on the substrate, and a magnetic material that generates a magnetic field aligned with respect to the second electrochemical sensor. The magnetic field captures magnetic beads that have an immobilized layer of antibody configured to bind to the analyte, and concentrates the magnetic beads on or near a surface of the second electrochemical sensor.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/549 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C08L 79/08 - Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
  • C01G 53/00 - Compounds of nickel
  • C08L 29/04 - Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
  • G01N 27/327 - Biochemical electrodes
  • C01F 17/30 - Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6

36.

Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity

      
Application Number 15836024
Grant Number 10928388
Status In Force
Filing Date 2017-12-08
First Publication Date 2018-06-14
Grant Date 2021-02-23
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Miller, Cary James

Abstract

The present invention relates to methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a method includes forming, in a biological sample, a first complex of signal antibodies and analyte, and a second complex of the first complex and capture antibodies immobilized on magnetic beads, and contacting a first immunosensor with the biological sample to form a third complex localized on or near a surface of the first immunosensor. The first immunosensor includes an immobilized layer of capture antibodies configured to bind to the analyte, and the third complex includes the first complex bound to the immobilized layer of capture antibodies. The method further includes contacting a magnetic field localized around a second immunosensor with the biological sample such that the second complex is localized on or near a surface of the second immunosensor.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/539 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

37.

Crossover analytical systems and methods using an immunosensor and magnetic immunosensor

      
Application Number 15836078
Grant Number 10871488
Status In Force
Filing Date 2017-12-08
First Publication Date 2018-06-14
Grant Date 2020-12-22
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Hu, Jing Hua
  • Virtanen, Antti Leo Oskari
  • Miller, Cary James
  • Campbell, John Lewis Emerson
  • Moss, Adam Roger

Abstract

The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a method includes determining a first concentration of an analyte at a first immunosensor from a reaction of a signal agent with a first complex of signal antibodies, the analyte, and capture antibodies immobilized on a surface of the first immunosensor, determining a second concentration of the analyte at a second immunosensor from a reaction of the signal agent with a second complex of the signal antibodies, the analyte, and capture antibodies immobilized on magnetic beads that are localized on or near a surface of the second immunosensor via a magnetic field, determining a weighted average of the first concentration and the second concentration, and comparing the weighted average to a predetermined crossover concentration point or zone.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • G01N 33/541 - Double or second antibody

38.

Method for imaging biologic fluid samples using a predetermined distribution

      
Application Number 15886324
Grant Number 10048248
Status In Force
Filing Date 2018-02-01
First Publication Date 2018-06-07
Grant Date 2018-08-14
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Xie, Min
  • Wardlaw, Stephen C.

Abstract

A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 15/14 - Electro-optical investigation
  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • G01N 15/02 - Investigating particle size or size distribution
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

39.

Self correction for spatial orientation and motion of portable clinical analyzers

      
Application Number 15877626
Grant Number 10468123
Status In Force
Filing Date 2018-01-23
First Publication Date 2018-06-07
Grant Date 2019-11-05
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G16B 99/00 - Subject matter not provided for in other groups of this subclass
  • G01N 27/327 - Biochemical electrodes
  • G01N 33/487 - Physical analysis of biological material of liquid biological material

40.

Portable clinical analysis system for immunometric measurement

      
Application Number 15868549
Grant Number 10942173
Status In Force
Filing Date 2018-01-11
First Publication Date 2018-05-17
Grant Date 2021-03-09
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Miller, Cary

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

41.

Management system for point of care testing

      
Application Number 15702924
Grant Number 10984366
Status In Force
Filing Date 2017-09-13
First Publication Date 2018-01-04
Grant Date 2021-04-20
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann
  • Emeric, Pierre
  • Molloy, Dan
  • Weber, Maureen
  • Fetters, Christopher

Abstract

The present invention relates to a method and system for quality compliance, system and operator verification, and process management for point of care biological sample testing systems used in hospitals and other medical delivery environments. Specifically, the present invention may be directed to a computing device configured to generate a plurality of attributes configured to assess a competency level of an operator to operate at least one sample testing instrument, obtain operator derived data pertaining to the operator's ability to operate the at least one sample testing instrument, and determine a competency level of the operator for the at least one sample testing instrument based the plurality of attributes and the operator derived data.

IPC Classes  ?

  • G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
  • G06Q 30/00 - Commerce
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

42.

Method and apparatus for automated whole blood sample analyses from microscopy images

      
Application Number 15487870
Grant Number 10365203
Status In Force
Filing Date 2017-04-14
First Publication Date 2017-08-03
Grant Date 2019-07-30
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Herzog, David
  • Wang, Zhizhou
  • Wardlaw, Stephen C.
  • Xie, Min

Abstract

A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • G01N 15/14 - Electro-optical investigation
  • G01N 21/59 - Transmissivity
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

43.

Integrated cartridge housings for sample analysis

      
Application Number 15419097
Grant Number 10406523
Status In Force
Filing Date 2017-01-30
First Publication Date 2017-05-18
Grant Date 2019-09-10
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Doyle, Kevin John
  • Wilkins, Paul
  • Withers, Mick
  • Cooper, Adrian
  • Noell, John Oakey

Abstract

The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

44.

Method for imaging biologic fluid samples using a predetermined distribution

      
Application Number 15398299
Grant Number 09885701
Status In Force
Filing Date 2017-01-04
First Publication Date 2017-04-27
Grant Date 2018-02-06
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Xie, Min
  • Wardlaw, Stephen C.

Abstract

A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • G01N 15/02 - Investigating particle size or size distribution
  • G01N 15/14 - Electro-optical investigation
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

45.

Spatial orientation determination in portable clinical analysis systems

      
Application Number 15291454
Grant Number 09915643
Status In Force
Filing Date 2016-10-12
First Publication Date 2017-02-02
Grant Date 2018-03-13
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

46.

Systems and methods for assuring quality compliance of point-of-care instruments used with single-use testing devices

      
Application Number 15145899
Grant Number 11002747
Status In Force
Filing Date 2016-05-04
First Publication Date 2016-12-08
Grant Date 2021-05-11
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann

Abstract

The present invention relates to systems and methods of determining quality compliance for one or more biological sample testing instruments used with one or more type of single-use blood testing cartridge, at the point-of-care in a hospital, or other location that deliver medical care. In particular, the systems and methods ensure that only instruments that pass a quality assurance protocol are used for point-of-care testing.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

47.

Systems for assuring quality compliance of point-of-care single-use testing devices

      
Application Number 15145934
Grant Number 10557862
Status In Force
Filing Date 2016-05-04
First Publication Date 2016-12-08
Grant Date 2020-02-11
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann

Abstract

The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

48.

Optical assay device with pneumatic sample actuation

      
Application Number 15163896
Grant Number 10690664
Status In Force
Filing Date 2016-05-25
First Publication Date 2016-09-15
Grant Date 2020-06-23
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Davis, Graham
  • Ewart, Thomas
  • Gershtein, Sergey

Abstract

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to test devices, e.g., cartridges, methods and systems, wherein the test devices have an entry port configured to receive a test sample into a holding chamber; a first conduit having at least one lateral flow test strip; and a displacement device, such as a pneumatic pump, configured to move a portion of said test sample from said holding chamber into said first conduit. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/76 - Human chorionic gonadotropin
  • G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody

49.

Portable clinical diagnostic instrument

      
Application Number 29523995
Grant Number D0765253
Status In Force
Filing Date 2015-04-15
First Publication Date 2016-08-30
Grant Date 2016-08-30
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Gershtein, Sergey
  • Patel, Jaymin
  • Schneider, Craig
  • Soman, Narendra

50.

Portable clinical diagnostic instrument

      
Application Number 29523978
Grant Number D0765252
Status In Force
Filing Date 2015-04-15
First Publication Date 2016-08-30
Grant Date 2016-08-30
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Gershtein, Sergey
  • Patel, Jaymin
  • Schneider, Craig
  • Soman, Narendra

51.

Oscillating immunoassay method and device

      
Application Number 15086340
Grant Number 10048258
Status In Force
Filing Date 2016-03-31
First Publication Date 2016-07-28
Grant Date 2018-08-14
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Campbell, John Lewis Emerson

Abstract

The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

52.

Magnetic immunosensor and method of use

      
Application Number 14976318
Grant Number 09958440
Status In Force
Filing Date 2015-12-21
First Publication Date 2016-04-21
Grant Date 2018-05-01
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Hu, Jinghua

Abstract

The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids

53.

Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples

      
Application Number 14866316
Grant Number 10247741
Status In Force
Filing Date 2015-09-25
First Publication Date 2016-03-31
Grant Date 2019-04-02
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zhao, Tian-Xian
  • Wong, Anjulia Chiu-Yuk
  • Martin, Glenn Brian
  • Di Tullio, Katrina Petronilla
  • Thibodeau, Isabelle Louisette
  • Breeze, Steven Roy
  • Sutrala, Smitha Rk
  • Hong, Eric
  • Taylor, Jay Kendall
  • Ball, Sheila Diane

Abstract

The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.

IPC Classes  ?

  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 27/403 - Cells and electrode assemblies
  • G01N 27/416 - Systems
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

54.

Cartridge device with segmented fluidics for assaying coagulation in fluid samples

      
Application Number 14866402
Grant Number 10048281
Status In Force
Filing Date 2015-09-25
First Publication Date 2016-03-31
Grant Date 2018-08-14
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Di Tullio, Katrina Petronilla
  • Taylor, Jay Kendall
  • Campbell, John Lewis Emerson
  • Elbuken, Caglar
  • Ball, Shelia Diane
  • Lightstone, Noam Saul

Abstract

The present invention relates to analytical testing devices comprising segmented fluidics and methods for assaying coagulation in a fluid sample received within the segmented fluidics. For example, the present invention may be directed to sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region. The sample analysis cartridge further includes a pump configured to independently mix the first segment in the second conduit and the second segment in the third conduit, and independently position the first segment over the first sensor region and position the second segment over the second sensor region.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
  • G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time

55.

Cartridge device with fluidic junctions for coagulation assays in fluid samples

      
Application Number 14866432
Grant Number 10048282
Status In Force
Filing Date 2015-09-25
First Publication Date 2016-03-31
Grant Date 2018-08-14
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Di Tullio, Katrina Petronilla
  • Taylor, Jay Kendall
  • Lee-Yow, Niko Daniel
  • Ball, Sheila Diane
  • Campbell, John Lewis Emerson

Abstract

The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
  • G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 27/416 - Systems
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

56.

Single channel cartridge device for coagulation assays in fluid samples

      
Application Number 14866460
Grant Number 10114031
Status In Force
Filing Date 2015-09-25
First Publication Date 2016-03-31
Grant Date 2018-10-30
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Di Tullio, Katrina Petronilla
  • Taylor, Jay Kendall
  • Lee-Yow, Niko Daniel
  • Ball, Sheila Diane

Abstract

The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
  • G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 27/403 - Cells and electrode assemblies
  • G01N 27/416 - Systems
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

57.

Ellagic acid formulations for use in coagulation assays

      
Application Number 14866518
Grant Number 09921232
Status In Force
Filing Date 2015-09-25
First Publication Date 2016-03-31
Grant Date 2018-03-20
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Collier, Gordon Bruce
  • Johns, Jr., Paul Willis
  • Sutrala, Smitha R K
  • Wang, Dan
  • Di Tullio, Katrina Petronilla

Abstract

The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.

IPC Classes  ?

  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

58.

Sensors for assaying coagulation in fluid samples

      
Application Number 14866266
Grant Number 09903877
Status In Force
Filing Date 2015-09-25
First Publication Date 2016-03-31
Grant Date 2018-02-27
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zhao, Tian-Xian
  • Wong, Anjulia Chiu-Yuk
  • Martin, Glenn Brian
  • Di Tullio, Katrina Petronilla
  • Thibodeau, Isabelle Louisette
  • Breeze, Steven Roy
  • Sutrala, Smitha R K
  • Hong, Eric
  • Ball, Sheila Diane

Abstract

The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.

IPC Classes  ?

  • C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

59.

Methods and devices for determining sensing device usability

      
Application Number 14927508
Grant Number 09417201
Status In Force
Filing Date 2015-10-30
First Publication Date 2016-02-25
Grant Date 2016-08-16
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Martin, Glenn
  • Wang, Yi
  • Tonks, Simon
  • Feldman, Benjamin J.

Abstract

Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

IPC Classes  ?

  • G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
  • G01R 35/00 - Testing or calibrating of apparatus covered by the other groups of this subclass

60.

Reader devices for optical and electrochemical test devices

      
Application Number 14919377
Grant Number 09488585
Status In Force
Filing Date 2015-10-21
First Publication Date 2016-02-11
Grant Date 2016-11-08
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Davis, Graham
  • Ewart, Thomas
  • Gershtein, Sergey

Abstract

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
  • G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator

61.

Biologic fluid sample analysis cartridge with non-reflective beads

      
Application Number 14768680
Grant Number 10895524
Status In Force
Filing Date 2014-02-19
First Publication Date 2016-01-07
Grant Date 2021-01-19
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Mehta, Manav
  • Holt, Robert

Abstract

A biological fluid sample analysis chamber and a method for analyzing a biological fluid sample is provided. The chamber includes a first chamber panel, a second chamber panel, and a plurality of beads disposed between the first chamber panel and the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the biologic fluid.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • G01N 15/05 - Investigating sedimentation of particle suspensions in blood
  • B01L 9/00 - Supporting devices; Holding devices
  • G01N 21/03 - Cuvette constructions
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 21/59 - Transmissivity
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

62.

Method for imaging biologic fluid samples using a predetermined distribution

      
Application Number 14650228
Grant Number 09576180
Status In Force
Filing Date 2013-12-06
First Publication Date 2015-11-05
Grant Date 2017-02-21
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Xie, Min
  • Wardlaw, Stephen C.

Abstract

A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

IPC Classes  ?

  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 15/02 - Investigating particle size or size distribution
  • G01N 15/14 - Electro-optical investigation
  • G01N 33/483 - Physical analysis of biological material
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

63.

Reagents for reducing leukocyte interference in immunoassays

      
Application Number 14673364
Grant Number 09316638
Status In Force
Filing Date 2015-03-30
First Publication Date 2015-10-01
Grant Date 2016-04-19
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Campbell, John Lewis Emerson
  • Davis, Graham
  • Omakor, John Emegbero
  • Moss, Adam Roger
  • Guhados, Ganesh

Abstract

Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/537 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones

64.

Medical data acquisition and patient management system and method

      
Application Number 14675144
Grant Number 10290366
Status In Force
Filing Date 2015-03-31
First Publication Date 2015-10-01
Grant Date 2019-05-14
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Tirinato, Jody Ann
  • Maund, Mark Paul
  • Machiaverna, Paul
  • Gibson, Paul Andrew
  • Vandersleen, Gary John
  • Ibanez, Rosa Margarita
  • Zaltsman, Lyudmila
  • Zelin, Michael P.

Abstract

A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.

IPC Classes  ?

  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G06Q 50/24 - Patient record management (processing of medical or biological data for scientific purposes G06F 19/00)
  • G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
  • G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

65.

Ratiometric immunoassay method and blood testing device

      
Application Number 14702511
Grant Number 09778251
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-09-03
Grant Date 2017-10-03
Owner Abbott Point of Care Inc. (USA)
Inventor Miller, Cary James

Abstract

The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin Alc or albumin and glycosylated albumin. The devices are preferably capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody

66.

Ratiometric immunoassay method and blood testing device

      
Application Number 14702501
Grant Number 09795962
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2017-10-24
Owner Abbott Point of Care Inc. (USA)
Inventor Miller, Cary James

Abstract

The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin A1c or albumin and glycosylated albumin. The devices are preferably capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/76 - Human chorionic gonadotropin
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

67.

Assay devices with integrated sample dilution and dilution verification and methods of using same

      
Application Number 14702565
Grant Number 09903875
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2018-02-27
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Davis, Graham
  • Zelin, Michael

Abstract

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

IPC Classes  ?

  • G01N 33/76 - Human chorionic gonadotropin
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

68.

Assay devices with integrated sample dilution and dilution verification and methods of using same

      
Application Number 14702576
Grant Number 09933422
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2018-04-03
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Davis, Graham
  • Zelin, Michael

Abstract

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
  • G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis

69.

Assay devices with integrated sample dilution and dilution verification and methods of using same

      
Application Number 14702585
Grant Number 09766232
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2017-09-19
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Davis, Graham
  • Zelin, Michael

Abstract

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
  • G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis

70.

Assay devices with integrated sample dilution and dilution verification and methods of using same

      
Application Number 14702594
Grant Number 09841396
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2017-12-12
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Davis, Graham
  • Zelin, Michael

Abstract

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • G01N 27/49 - Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

71.

Ratiometric immunoassay method and blood testing device

      
Application Number 14702472
Grant Number 09778271
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2017-10-03
Owner Abbott Point of Care Inc. (USA)
Inventor Miller, Cary James

Abstract

The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin A1c or albumin and glycosylated albumin. The devices are preferably capable of being used in the point-of-care diagnostic field.

IPC Classes  ?

  • G01N 33/76 - Human chorionic gonadotropin
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

72.

Assay devices with integrated sample dilution and dilution verification and methods of using same

      
Application Number 14702590
Grant Number 09846152
Status In Force
Filing Date 2015-05-01
First Publication Date 2015-08-20
Grant Date 2017-12-19
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Miller, Cary James
  • Davis, Graham
  • Zelin, Michael

Abstract

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 27/413 - Concentration cells using liquid electrolytes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

73.

Multi-fluidic cartridges for sample analysis and methods for using same

      
Application Number 14472812
Grant Number 09770716
Status In Force
Filing Date 2014-08-29
First Publication Date 2014-12-18
Grant Date 2017-09-26
Owner Abbott Point of Care Inc. (USA)
Inventor Miller, Cary James

Abstract

The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and (c) at least one pneumatic pump configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit.

IPC Classes  ?

  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/00 - Sampling; Preparing specimens for investigation

74.

Integrated hinged cartridge housings for sample analysis

      
Application Number 14299259
Grant Number 09415389
Status In Force
Filing Date 2014-06-09
First Publication Date 2014-10-09
Grant Date 2016-08-16
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Doyle, Kevin John
  • Wilkins, Paul
  • Withers, Mick
  • Cooper, Adrian
  • Noell, John Oakey

Abstract

The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing comprising a first substantially rigid zone, a second substantially flexible zone, a hinge region, and at least one sensor recess containing a sensor. The housing is foldable about said hinge region to form a cartridge having a conduit over at least a portion of said sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

75.

Biosensor with improved interference characteristics

      
Application Number 14206174
Grant Number 09562874
Status In Force
Filing Date 2014-03-12
First Publication Date 2014-09-18
Grant Date 2017-02-07
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Martin, Glenn
  • Collier, G. Bruce
  • Wang, Dan

Abstract

2, NAD, NADP, etc., which will improve the assay performance with less interference and higher sensitivity.

IPC Classes  ?

  • G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • G01N 27/327 - Biochemical electrodes

76.

Thermal control system for controlling the temperature of a fluid

      
Application Number 14206547
Grant Number 10981172
Status In Force
Filing Date 2014-03-12
First Publication Date 2014-09-18
Grant Date 2021-04-20
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary J.
  • Gershtein, Sergey
  • Tilson, Mitchell
  • Patel, Jaymin
  • Schneider, Craig H.
  • Hunter, Seth
  • Wasserman, Paul
  • Emeric, Pierre

Abstract

The invention relates to a thermal control system for controlling the temperature of a fluid. In particular, the invention relates to a control system having at least two heating elements, at least one of which is used for directly or indirectly heating a fluid, and at least one of which is used for heating a thermal probe used to determine the temperature of the fluid. The heating systems are controlled by at least one feedback controller.

IPC Classes  ?

  • G05D 23/30 - Automatic controllers with an auxiliary heating device affecting the sensing element, e.g. for anticipating change of temperature
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

77.

Biosensor structures for improved point of care testing and methods of manufacture thereof

      
Application Number 14206636
Grant Number 09487811
Status In Force
Filing Date 2014-03-12
First Publication Date 2014-09-18
Grant Date 2016-11-08
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zhao, Tian-Xian
  • Martin, Glenn
  • Hardage, Kenneth
  • Breeze, Steven R.
  • Snyder, Stephen

Abstract

The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.

IPC Classes  ?

  • G01N 27/327 - Biochemical electrodes
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions

78.

Management system for point of care testing

      
Application Number 14206693
Grant Number 09792572
Status In Force
Filing Date 2014-03-12
First Publication Date 2014-09-18
Grant Date 2017-10-17
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Glavina, Paul
  • Tirinato, Jody Ann
  • Emeric, Pierre
  • Molloy, Dan
  • Weber, Maureen
  • Fetters, Christopher

Abstract

The present invention relates to a method and system for quality compliance, system and operator verification, and process management for point of care biological sample testing systems used in hospitals and other medical delivery environments. Specifically, the present invention may be directed to a computing device configured to generate a plurality of attributes configured to assess a competency level of an operator to operate at least one sample testing instrument, obtain operator derived data pertaining to the operator's ability to operate the at least one sample testing instrument, and determine a competency level of the operator for the at least one sample testing instrument based the plurality of attributes and the operator derived data.

IPC Classes  ?

  • G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
  • G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
  • G06Q 30/00 - Commerce

79.

Electrochemical methods and devices for amending urine samples for immunosensor detection

      
Application Number 14206831
Grant Number 09488663
Status In Force
Filing Date 2014-03-12
First Publication Date 2014-09-18
Grant Date 2016-11-08
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Di Tullio, Katrina
  • Collier, G. Bruce
  • Campbell, John Lewis Emerson

Abstract

The present invention is directed to methods and devices for amending undiluted and partially diluted urine samples in a manner suitable for performing immunoassays for target analytes, for example NGAL. Generally, the urine sample is treated with reagents including at least one of buffer materials, water soluble proteins, urease, and other interferent mitigants. These reagents control the pH of the urine sample in a manner suitable for immuno-binding reactions and ameliorate interferences, particularly during the detection step.

IPC Classes  ?

  • C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/62 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

80.

Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays

      
Application Number 14141851
Grant Number 09671398
Status In Force
Filing Date 2013-12-27
First Publication Date 2014-07-03
Grant Date 2017-06-06
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Campbell, John
  • Nguyen, Linda
  • Smith, James
  • Weiss, Wenda
  • Dowell, Barry Lee

Abstract

The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample. The system may further include a processor configured to determine a presence of a hook effect in the immunoassay based on relative values of the first and second signals and optionally determine the target analyte concentration of the sample.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

81.

Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays

      
Application Number 14141837
Grant Number 08852877
Status In Force
Filing Date 2013-12-27
First Publication Date 2014-07-03
Grant Date 2014-10-07
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Campbell, John
  • Nguyen, Linda
  • Smith, James
  • Weiss, Wenda

Abstract

The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For example, a system for identifying a hook effect and expanding the dynamic range of an immunoassay is provided that may include a primary sensor having first immobilized antibodies that may be configured to generate a first signal based on a presence or absence of a target analyte in a sample. The system may further include an attenuated sensor having second immobilized antibodies at a reduced concentration relative to a concentration of the first immobilized antibodies on the primary sensor and that may be configured to generate a second signal based on the presence or absence of the target analyte in the sample. The system may further include a processor configured to determine a presence of a hook effect in the immunoassay based on relative values of the first and second signals and optionally determine the target analyte concentration of the sample.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

82.

Spatial orientation determination in portable clinical analysis systems

      
Application Number 14099470
Grant Number 09494578
Status In Force
Filing Date 2013-12-06
First Publication Date 2014-06-19
Grant Date 2016-11-15
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/487 - Physical analysis of biological material of liquid biological material

83.

Self correction for spatial orientation and motion of portable clinical analyzers

      
Application Number 14099479
Grant Number 09904761
Status In Force
Filing Date 2013-12-06
First Publication Date 2014-06-19
Grant Date 2018-02-27
Owner Abbot Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01D 18/00 - Testing or calibrating apparatus or arrangements provided for in groups
  • G06F 19/10 - Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology (in silico methods of screening virtual chemical libraries C40B 30/02;in silico or mathematical methods of creating virtual chemical libraries C40B 50/02)
  • G01N 27/327 - Biochemical electrodes
  • G01N 33/487 - Physical analysis of biological material of liquid biological material

84.

Portable clinical analysis system for immunometric measurement

      
Application Number 14099398
Grant Number 09885706
Status In Force
Filing Date 2013-12-06
First Publication Date 2014-06-19
Grant Date 2018-02-06
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Miller, Cary

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

85.

Operation and verification of a portable clinical analysis system

      
Application Number 14099419
Grant Number 09952194
Status In Force
Filing Date 2013-12-06
First Publication Date 2014-06-19
Grant Date 2018-04-24
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Fetters, Christopher

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 27/327 - Biochemical electrodes

86.

Portable clinical analysis system for hematocrit measurement

      
Application Number 14099504
Grant Number 09949674
Status In Force
Filing Date 2013-12-06
First Publication Date 2014-06-19
Grant Date 2018-04-24
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Vandersleen, Gary
  • Emeric, Pierre
  • Wasserman, Paul
  • Soman, Narendra
  • Davis, Graham
  • Zhao, Tian-Xian
  • Glavina, Paul

Abstract

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 27/327 - Biochemical electrodes

87.

Method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample

      
Application Number 13925295
Grant Number 08781203
Status In Force
Filing Date 2013-06-24
First Publication Date 2014-01-02
Grant Date 2014-07-15
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Davis, Graham
  • Wardlaw, Stephen C.
  • Levine, Robert A.
  • Unfricht, Darryn W.
  • Lalpuria, Niten
  • Mitsis, Paul G.

Abstract

A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.

IPC Classes  ?

  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

88.

Integrated cartridge housings for sample analysis

      
Application Number 13530501
Grant Number 09592507
Status In Force
Filing Date 2012-06-22
First Publication Date 2013-12-26
Grant Date 2017-03-14
Owner ABBOTT POINT OF CARE INC. (USA)
Inventor
  • Doyle, Kevin John
  • Wilkins, Paul
  • Withers, Mick
  • Cooper, Adrian
  • Noell, John Oakey

Abstract

The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

89.

Quality assurance system and method for point-of-care testing

      
Application Number 13930299
Grant Number 09772302
Status In Force
Filing Date 2013-06-28
First Publication Date 2013-11-07
Grant Date 2017-09-26
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Zelin, Michael P.
  • Brouwer, Eric
  • Breeze, Steven

Abstract

An improved quality assurance system and method for point-of-care testing are disclosed. The present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care without the need for running liquid-based quality control materials on the analysis system. Quality assurance of a quantitative physiological sample test system is performed without using a quality control sample by monitoring the thermal and temporal stress of a component used with the test system. Alert information is generated that indicates that the component has failed quality assurance when the thermal and temporal stress exceeds a predetermined thermal-temporal stress threshold. Alternatively, the present invention provides quality assurance for laboratory quality tests performed by a blood analysis system or the like at the point of patient care by minimizing the need for running liquid-based quality control materials on the analysis system.

IPC Classes  ?

  • G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
  • G01N 27/416 - Systems
  • G01K 3/04 - Thermometers giving results other than momentary value of temperature giving integrated values in respect of time
  • G01N 27/327 - Biochemical electrodes
  • G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

90.

Method and device for immunoassay using nucleotide conjugates

      
Application Number 13865425
Grant Number 09207246
Status In Force
Filing Date 2013-04-18
First Publication Date 2013-09-05
Grant Date 2015-12-08
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Collier, G. Bruce
  • Miller, Cary James

Abstract

A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

91.

Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells

      
Application Number 13751938
Grant Number 08778687
Status In Force
Filing Date 2013-01-28
First Publication Date 2013-08-15
Grant Date 2014-07-15
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Levine, Robert A.
  • Wardlaw, Stephen C.
  • Unfricht, Darryn
  • Lalpuria, Niten V.

Abstract

A method and apparatus for determining the hematocrit of a blood sample disposed within an analysis chamber, the method including the steps of: a) imaging at least a portion of the sample that contains one or more red blood cells and one or more areas void of red blood cells; b) determining a representative optical density value for a plurality of image units optically aligned with portions of the red blood cells, and assigning an optical density first boundary value to those image units; c) determining a representative optical density value of a plurality of image units optically aligned with the one or more regions of the sample devoid of red blood cells, and assigning a second optical density boundary value to those image units; and d) determining the hematocrit of the sample.

IPC Classes  ?

  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
  • G01N 33/72 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. hemoglobin, bilirubin
  • G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types
  • G01N 15/14 - Electro-optical investigation

92.

Optical assay device with pneumatic sample actuation

      
Application Number 13724363
Grant Number 09377475
Status In Force
Filing Date 2012-12-21
First Publication Date 2013-07-25
Grant Date 2016-06-28
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Davis, Graham
  • Ewart, Thomas
  • Gershtein, Sergey

Abstract

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to test devices, e.g., cartridges, methods and systems, wherein the test devices have an entry port configured to receive a test sample into a holding chamber; a first conduit having at least one lateral flow test strip; and a displacement device, such as a pneumatic pump, configured to move a portion of said test sample from said holding chamber into said first conduit. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/76 - Human chorionic gonadotropin
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

93.

Integrated test device for optical detection of microarrays

      
Application Number 13724370
Grant Number 09140693
Status In Force
Filing Date 2012-12-21
First Publication Date 2013-07-18
Grant Date 2015-09-22
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Ewart, Thomas
  • Davis, Graham
  • Emeric, Pierre
  • Gershtein, Sergey
  • Sutrala, Smitha
  • Di Tullio, Katrina

Abstract

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

94.

Method and apparatus for detecting and counting platelets individually and in aggregate clumps

      
Application Number 13673616
Grant Number 08638427
Status In Force
Filing Date 2012-11-09
First Publication Date 2013-07-11
Grant Date 2014-01-28
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Wardlaw, Stephen C.
  • Levine, Robert A.
  • Lalpuria, Niten V.

Abstract

A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into a sample container having an analysis chamber adapted to quiescently hold the sample for analysis, and an amount of colorant that platelets absorb and which fluoresces upon exposure to one or more predetermined first wavelengths of light; 2) imaging at least a portion of the sample disposed in the analysis chamber, including producing image signals indicative of fluorescent emissions from the platelets illuminated by first wavelengths of light; 3) identifying the platelets using the image signals; and 4) enumerating individual platelets and clumped platelets within the sample using one or more of fluorescent emissions, area, shape, and granularity.

IPC Classes  ?

  • G01N 33/38 - Concrete; Lime; Mortar; Gypsum; Bricks; Ceramics; Glass
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

95.

Method and apparatus for identifying reticulocytes within a blood sample

      
Application Number 13673644
Grant Number 08885154
Status In Force
Filing Date 2012-11-09
First Publication Date 2013-07-04
Grant Date 2014-11-11
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Wardlaw, Stephen C.
  • Levine, Robert A.
  • Unfricht, Darryn W.
  • Lalpuria, Niten V.
  • Hill, Jeremy R.

Abstract

A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values.

IPC Classes  ?

  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G06T 7/00 - Image analysis
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

96.

Integrated test device for optical and electrochemical assays

      
Application Number 13724383
Grant Number 09335290
Status In Force
Filing Date 2012-12-21
First Publication Date 2013-06-27
Grant Date 2016-05-10
Owner Abbott Point of Care, Inc. (USA)
Inventor
  • Ewart, Thomas
  • Davis, Graham
  • Emeric, Pierre
  • Gershtein, Sergey

Abstract

This invention relates generally to test devices and methods for performing optical and electrochemical assays and, more particularly, to test devices having the ability to perform optical and electrochemical assays on a sample and to methods of performing optical and electrochemical assays using such test devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a furthe
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

97.

Reader devices for optical and electrochemical test devices

      
Application Number 13724348
Grant Number 09194859
Status In Force
Filing Date 2012-12-21
First Publication Date 2013-06-27
Grant Date 2015-11-24
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Emeric, Pierre
  • Davis, Graham
  • Ewart, Thomas
  • Gershtein, Sergey

Abstract

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

IPC Classes  ?

  • G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

98.

Methods and devices for determining sensing device usability

      
Application Number 13538032
Grant Number 09792838
Status In Force
Filing Date 2012-06-29
First Publication Date 2013-01-03
Grant Date 2017-10-17
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Martin, Glenn
  • Zhao, Tian-Xian
  • Snyder, Stephen Lee

Abstract

Methods and devices for determining device usability, e.g., for point of care assay devices. In one embodiment, the invention is to a method of determining device usability in a sensing device, including the steps of: providing a device comprising a first electrical pad; a second electrical pad; and a first polymer layer contacting at least a portion of the first and the second electrical pads and a second polymer layer contacting the first polymer layer and not the first and second electrical pads; applying a potential across the first and the second electrical pads; measuring an electrical property associated with the first and the second polymer layers; and determining whether the measured electrical property associated with the first and the second polymer layers has exceeded a threshold level associated with the device usability.

IPC Classes  ?

  • G01R 27/08 - Measuring resistance by measuring both voltage and current
  • G01R 35/00 - Testing or calibrating of apparatus covered by the other groups of this subclass
  • G09F 3/00 - Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
  • G01N 27/06 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
  • G01N 27/327 - Biochemical electrodes

99.

Methods and devices for determining sensing device usability

      
Application Number 13537983
Grant Number 09201034
Status In Force
Filing Date 2012-06-29
First Publication Date 2013-01-03
Grant Date 2015-12-01
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Martin, Glenn
  • Wang, Yi
  • Tonks, Simon
  • Feldman, Benjamin J.

Abstract

Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

IPC Classes  ?

  • G01R 31/3187 - Built-in tests
  • G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance

100.

Methods and devices for determining sensing device usability

      
Application Number 13538148
Grant Number 09224312
Status In Force
Filing Date 2012-06-29
First Publication Date 2013-01-03
Grant Date 2015-12-29
Owner Abbott Point of Care Inc. (USA)
Inventor
  • Martin, Glenn
  • Zhao, Tian-Xian
  • Breeze, Steven
  • Jeffrey, Craig
  • Snyder, Stephen Lee

Abstract

Methods and devices for determining sensing device usability, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; and determining whether the measured electrical property associated with the continuous polymer layer has exceeded a threshold level associated with the device usability.

IPC Classes  ?

  • G01R 31/3187 - Built-in tests
  • B05D 5/12 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a coating with specific electrical properties
  • G01N 27/20 - Investigating the presence of flaws
  • G09F 3/00 - Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
  • G01N 27/327 - Biochemical electrodes
  1     2        Next Page