Cepheid

United States of America

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IPC Class
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 63
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 62
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices 32
C12Q 1/686 - Polymerase chain reaction [PCR] 29
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor 22
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NICE Class
10 - Medical apparatus and instruments 30
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1.

MPOX CLADE II BIOMARKER PANEL

      
Application Number 18540460
Status Pending
Filing Date 2023-12-14
First Publication Date 2024-07-04
Owner Cepheid (USA)
Inventor
  • Jones, Robert
  • Mangipudi, Kalyani
  • Chakravorty, Soumitesh
  • Ozay, Burcu

Abstract

The present disclosure provides a set of primers and optional probes for identifying the presence of MPOX virus, Clade II, which can be included with (e.g., in at kit) or in a cartridge for automated detection of these pathogens by nucleic acid amplification. This disclosure also provides related detection methods, as well as cartridges, systems, and kits useful in such methods.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

2.

MPOX CLADE II BIOMARKER PANEL

      
Application Number US2023084071
Publication Number 2024/129998
Status In Force
Filing Date 2023-12-14
Publication Date 2024-06-20
Owner CEPHEID (USA)
Inventor
  • Jones, Robert
  • Mangipudi, Kalyani
  • Chakravorty, Soumitesh
  • Ozay, Burcu

Abstract

The present disclosure provides a set of primers and optional probes for identifying the presence of MPOX virus, Clade II, which can be included with (e.g., in at kit) or in a cartridge for automated detection of these pathogens by nucleic acid amplification. This disclosure also provides related detection methods, as well as cartridges, systems, and kits useful in such methods.

3.

Methods of Detecting Bladder Cancer

      
Application Number 18485615
Status Pending
Filing Date 2023-10-12
First Publication Date 2024-05-30
Owner Cepheid (USA)
Inventor
  • Higuchi, Russell
  • Wallace, Stacey Ellen
  • Lai, Edwin Wei-Lung

Abstract

Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting a set of markers consisting of CRH, IGF2, KRT20, and ANXA10.

IPC Classes  ?

  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

4.

SEAL FAILURE DETECTION SYSTEM AND METHODS

      
Application Number 18460253
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-05-30
Owner Cepheid (USA)
Inventor
  • Fotkatzikis, Aristotelis
  • Venugopal, Vijay
  • Senn, Melanie
  • Chung, Koohong
  • Fessehatzion, Robel
  • Burnett, Percy B.

Abstract

Methods and systems for detecting defect in sample cartridges in real-time during manufacturing. Such systems utilize one or more external sensors that detect characteristics or parameters of the sample cartridge and/or the manufacturing process from one or more data sets. The external sensor(s) include any of: an RGB camera, IR camera, high-resolution optical camera, and ultrasonic microphone or combination thereof. An automated system obtains data sets from external sensor(s) and compares the data sets to a baseline of the sample cartridge and/or manufacturing process such that defects can be determined based on a variance from the baseline. Such methods can utilize feature extraction and spectrum analysis to identify features or characteristics for comparison with the baseline. A machine learning model can be used to determine an algorithm based on data sets of acceptable sample cartridges and data sets from the external sensor(s) that are associated with the cartridge defect.

IPC Classes  ?

  • G01N 29/04 - Analysing solids
  • B23K 20/10 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating making use of vibrations, e.g. ultrasonic welding
  • G01N 21/90 - Investigating the presence of flaws, defects or contamination in a container or its contents
  • G06T 7/00 - Image analysis

5.

FAULTY UNIT DETECTION SYSTEM AND METHODS

      
Application Number 18460266
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-05-30
Owner Cepheid (USA)
Inventor Chung, Koohong

Abstract

Methods and system for identifying faulty sample cartridges in real-time during manufacturing are provided herein. Such systems use monitored operational parameters associated with operation of manufacturing equipment that manufactures the sample cartridges. One or more data sets of operational parameters are obtained from existing equipment controls and/or additional sensors and compared to corresponding operational parameters associated with acceptable cartridges. A faulty detection unit can be configured to compare the operational parameters and can optionally include algorithms and/or models, such as a machine learning model, by which faulty cartridges can be identified. The comparison can include determining whether the monitored operational parameters are within a pre-defined range of acceptable values and/or deviate from a characteristic profile of the operational parameter in a manner indicative of faulty cartridges. The faulty cartridge detection can be integrated within automation controls so that faulty cartridges can be detected in real-time and automatically discarded during manufacturing.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

6.

TRANSFER LEARNING METHODS AND MODELS FACILITATING DEFECT DETECTION

      
Application Number 18460279
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-05-30
Owner Cepheid (USA)
Inventor
  • Senn, Melanie
  • Fotkatzikis, Aristotelis

Abstract

Methods and systems for training a model for automated defect detection of a product during manufacturing are provided herein. Such methods utilize a combination of supervised transfer learning through auxiliary tasks and a combination of supervised and unsupervised learning. The methods can utilize supervised transfer learning with expert labels on a generalized auxiliary task, such as product classification, which is transferred to more specific auxiliary tasks, such as identification of specific product features and/or anomaly detection, where additional expert labels are then applied to the anomalies, and another iteration of supervised learning further improves the model. The anomalies can correspond to features associated with defects, which can be induced experimentally to improve efficiency of the training procedure. The product can be a sample cartridge such that the model allows detection of faulty cartridges based on sample cartridge and/or manufacturing process data.

IPC Classes  ?

7.

MOTOR HAVING INTEGRATED ACTUATOR WITH ABSOLUTE ENCODER AND METHODS OF USE

      
Application Number 18527039
Status Pending
Filing Date 2023-12-01
First Publication Date 2024-05-30
Owner Cepheid (USA)
Inventor Phan, Tien

Abstract

A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with a first set of permanent magnets distributed radially about the rotor to facilitate rotation of the rotor and a second set of permanent magnets on the rotor to facilitate determination of an absolute position of the rotor. The motor further includes first and second set of sensors for detection of the magnets of the inner and outer rings. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an absolute position of the rotor relative the substrate to be determined from the sinusoidal signals without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.

IPC Classes  ?

  • H02P 7/025 - Arrangements for regulating or controlling the speed or torque of electric DC motors the DC motors being of the linear type the DC motors being of the moving coil type, e.g. voice coil motors
  • H02K 1/2791 - Surface mounted magnets; Inset magnets
  • H02K 1/2795 - Rotors axially facing stators the rotor consisting of two or more circumferentially positioned magnets

8.

FILM SEAL ASSEMBLY AND SINGLE LID ASSAY CARTRIDGE AND ASSOCIATED METHODS

      
Application Number 18475979
Status Pending
Filing Date 2023-09-27
First Publication Date 2024-05-23
Owner Cepheid (USA)
Inventor
  • Kurse, Rohan
  • Dority, Douglas B.
  • Magadum, Pradeep Shivalingappa
  • Umachandran, Kavya
  • Vang, Koua

Abstract

Film seal assemblies that seal one or more reagents within a sample cartridge, which allow for single lid cartridge designs. Such film seal assemblies can include one or more layers, a bottom-most layer that permanently seals with a sample cartridge having multiple chambers for one or more reagents, and top-most layer that releasably seals vent opening(s) in the film seal assembly and is removable by the end user. This configuration allows use of a single lid, which can be integrally formed with cartridge body or a separate component attached atop the cartridge body. The film seal assembly can include peelable liner(s) or can releasably attached to an underside of the single lid. Such film assemblies can include multiple layers that include a polypropylene layer for permanently sealing to a rigid propylene cartridge body and polyester top layers for releasably and hermetically sealing with a liner or the lid.

IPC Classes  ?

  • B65D 51/20 - Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing

9.

Diagnostic assay system

      
Application Number 29865799
Grant Number D1026244
Status In Force
Filing Date 2022-08-12
First Publication Date 2024-05-07
Grant Date 2024-05-07
Owner Cepheid (USA)
Inventor
  • Chang, Ronald
  • Mote, Gregory
  • Montgomery, Steven M.

10.

INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE

      
Application Number 18095982
Status Pending
Filing Date 2023-01-11
First Publication Date 2024-05-02
Owner Cepheid (USA)
Inventor
  • Lai, Edwin Wei-Lung
  • Kohlway, Andrew
  • Van Atta, Reuel
  • Higuchi, Russell
  • Gall, Alexander A.
  • Kocmond, Kriszten

Abstract

In various embodiments methods of determining methylation of DNA are provided. In one illustrative, but non-limiting embodiment the method comprises i) contacting a biological sample comprising a nucleic acid to a first matrix material comprising a first column or filter where said matrix material binds and/or filters nucleic acids in said sample and thereby purifies the DNA; ii) eluting the bound DNA from the first matrix material and denaturing the DNA to produce eluted denatured DNA; iii) heating the eluted DNA in the presence of bisulfite ions to produce a deaminated nucleic acid; iv) contacting said deaminated nucleic acid to a second matrix material comprising a second column to bind said deaminated nucleic acid to said second matrix material; v) desulfonating the bound deaminated nucleic acid and/or simultaneously eluting and desulfonating the nucleic acid by contacting the deaminated nucleic acid with an alkaline solution to produce a bisulfite converted nucleic acid; vi) eluting said bisulfite converted nucleic acid from said second matrix material; and vii) performing methylation specific PCR and/or nucleic acid sequencing, and/or high resolution melting analysis (HRM) on said bisulfite-converted nucleic acid to determine the methylation of said nucleic acid, wherein at least steps iv) through vi) are performed in a single reaction cartridge.

IPC Classes  ?

  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

11.

FILM SEAL ASSEMBLY AND SINGLE LID ASSAY CARTRIDGE AND ASSOCIATED METHODS

      
Application Number US2023033867
Publication Number 2024/072896
Status In Force
Filing Date 2023-09-27
Publication Date 2024-04-04
Owner CEPHEID (USA)
Inventor
  • Kurse, Rohan
  • Dority, Douglas B.
  • Magadum, Pradeep Shivalingappa
  • Umachandran, Kavya
  • Vang, Koua

Abstract

Film seal assemblies that seal one or more reagents within a sample cartridge, which allow for single lid cartridge designs. Such film seal assemblies can include one or more layers, a bottom-most layer that permanently seals with a sample cartridge having multiple chambers for one or more reagents, and top-most layer that releasably seals vent opening(s) in the film seal assembly and is removable by the end user. This configuration allows use of a single lid, which can be integrally formed with cartridge body or a separate component attached atop the cartridge body. The film seal assembly can include peelable liner(s) or can releasably attached to an underside of the single lid. Such film assemblies can include multiple layers that include a polypropylene layer for permanently sealing to a rigid propylene cartridge body and polyester top layers for releasably and hermetically sealing with a liner or the lid.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B65D 17/50 - Non-integral frangible members applied to, or inserted in, preformed openings, e.g. tearable strips or plastic plugs
  • B65D 51/16 - Closures not otherwise provided for with means for venting air or gas
  • B65D 51/22 - Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
  • B65D 53/08 - Flexible adhesive strips adapted to seal filling or discharging apertures
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

12.

EXPONENTIAL BASE-GREATER-THAN-BASE 2 NUCLEIC ACID AMPLIFICATION USING HIGH- AND LOW-Tm PRIMERS

      
Application Number 18109795
Status Pending
Filing Date 2023-02-14
First Publication Date 2024-03-28
Owner Cepheid (USA)
Inventor Lokhov, Sergey G.

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification. The method employs pairs of primers that differ significantly in Tm and a novel temperature/time course characterized by a temperature pulse during denaturation that enables a high-Tm primer (but not a low-Tm primer) to anneal and prime the synthesis of an additional nucleic acid strand beyond the two strands synthesized in a cycle of classical PCR. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.

IPC Classes  ?

13.

HONEYCOMB TUBE

      
Application Number 18350916
Status Pending
Filing Date 2023-08-07
First Publication Date 2024-03-07
Owner Cepheid (USA)
Inventor
  • Chiang, Yuh-Min
  • Dority, Doug
  • Dickens, Dustin
  • Glass, Jennifer
  • Van Atta, Reuel

Abstract

A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.

IPC Classes  ?

  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

14.

SEAL FAILURE DETECTION SYSTEM AND METHODS

      
Application Number US2023031901
Publication Number 2024/050121
Status In Force
Filing Date 2023-09-01
Publication Date 2024-03-07
Owner CEPHEID (USA)
Inventor
  • Fotkatzikis, Aristotelis
  • Venugopal, Vijayakumar C.
  • Senn, Melanie
  • Chung, Koohong
  • Fessehatzion, Robel
  • Burnett, Percy B.

Abstract

Methods and systems for detecting defect in sample cartridges in real-time during manufacturing. Such systems utilize one or more external sensors that detect characteristics or parameters of the sample cartridge and/or the manufacturing process from one or more data sets. The external sensor(s) include any of: an RGB camera, IR camera, high-resolution optical camera, and ultrasonic microphone or combination thereof. An automated system obtains data sets from external sensor(s) and compares the data sets to a baseline of the sample cartridge and/or manufacturing process such that defects can be determined based on a variance from the baseline. Such methods can utilize feature extraction and spectrum analysis to identify features or characteristics for comparison with the baseline. A machine learning model can be used to determine an algorithm based on data sets of acceptable sample cartridges and data sets from the external sensor(s) that are associated with the cartridge defect.

IPC Classes  ?

  • G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control (DNC), flexible manufacturing systems (FMS), integrated manufacturing systems (IMS), computer integrated manufacturing (CIM)
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B29C 65/08 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure using ultrasonic vibrations
  • B29C 65/82 - Testing the joint
  • B29C 65/00 - Joining of preformed parts; Apparatus therefor
  • G06T 7/00 - Image analysis

15.

FAULTY UNIT DETECTION SYSTEM AND METHODS

      
Application Number US2023031908
Publication Number 2024/050127
Status In Force
Filing Date 2023-09-01
Publication Date 2024-03-07
Owner CEPHEID (USA)
Inventor Chung, Koohong

Abstract

Methods and system for identifying faulty sample cartridges in real-time during manufacturing are provided herein. Such systems use monitored operational parameters associated with operation of manufacturing equipment that manufactures the sample cartridges. One or more data sets of operational parameters are obtained from existing equipment controls and/or additional sensors and compared to corresponding operational parameters associated with acceptable cartridges. A faulty detection unit can be configured to compare the operational parameters and can optionally include algorithms and/or models, such as a machine learning model, by which faulty cartridges can be identified. The comparison can include determining whether the monitored operational parameters are within a pre-defined range of acceptable values and/or deviate from a characteristic profile of the operational parameter in a manner indicative of faulty cartridges. The faulty cartridge detection can be integrated within automation controls so that faulty cartridges can be detected in real-time and automatically discarded during manufacturing.

IPC Classes  ?

  • G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control (DNC), flexible manufacturing systems (FMS), integrated manufacturing systems (IMS), computer integrated manufacturing (CIM)

16.

TRANSFER LEARNING METHODS AND MODELS FACILITATING DEFECT DETECTION

      
Application Number US2023031905
Publication Number 2024/050125
Status In Force
Filing Date 2023-09-01
Publication Date 2024-03-07
Owner CEPHEID (USA)
Inventor Senn, Melanie

Abstract

Methods and systems for training a model for automated defect detection of a product during manufacturing are provided herein. Such methods utilize a combination of supervised transfer learning through auxiliary tasks and a combination of supervised and unsupervised learning. The methods can utilize supervised transfer learning with expert labels on a generalized auxiliary task, such as product classification, which is transferred to more specific auxiliary tasks, such as identification of specific product features and/or anomaly detection, where additional expert labels are then applied to the anomalies, and another iteration of supervised learning further improves the model. The anomalies can correspond to features associated with defects, which can be induced experimentally to improve efficiency of the training procedure. The product can be a sample cartridge such that the model allows detection of faulty cartridges based on sample cartridge and/or manufacturing process data.

IPC Classes  ?

17.

SULFORHODAMINE PHOSPHORAMIDITE DYES

      
Application Number 17053683
Status Pending
Filing Date 2019-05-07
First Publication Date 2024-02-29
Owner CEPHEID (USA)
Inventor
  • Lund, Kevin P.
  • Sergueev, Dmitri
  • Qabar, Maher N.
  • Gall, Alexander

Abstract

Automated oligonucleotide synthesis-compatible sulforhodamine dye phosphoramidite compounds and labeled polynucleotides incorporating these dyes are provided.

IPC Classes  ?

  • C09B 11/24 - Phthaleins containing amino groups
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

18.

HONEYCOMB TUBE

      
Application Number 18481156
Status Pending
Filing Date 2023-10-04
First Publication Date 2024-02-29
Owner Cepheid (USA)
Inventor
  • Chiang, Yuh-Min
  • Dority, Douglas
  • Dickens, Dustin
  • Glass, Jennifer
  • Van Atta, Reuel

Abstract

A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having a well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.

IPC Classes  ?

  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

19.

NUCLEIC ACID EXTRACTION AND ISOLATION WITH HEAT LABILE SILANES AND CHEMICALLY MODIFIED SOLID SUPPORTS

      
Application Number 18309691
Status Pending
Filing Date 2023-04-28
First Publication Date 2024-02-01
Owner Cepheid (USA)
Inventor
  • Kutyavin, Alex I.
  • Lund, Kevin P.
  • Reed, Michael
  • Nakatani, Cameron J.
  • Nanassy, Oliver Z.
  • Leuzzi, Richard J.

Abstract

Compositions and methods for isolating and detecting nucleic acid in a biological sample are provided. The compositions and methods utilize a modified solid support comprising an amine or amide group.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

20.

SYSTEM, DEVICE AND METHODS OF SAMPLE PROCESSING USING SEMICONDUCTOR DETECTION CHIPS

      
Application Number 18358583
Status Pending
Filing Date 2023-07-25
First Publication Date 2024-01-25
Owner Cepheid (USA)
Inventor
  • Dority, Douglas B.
  • Siegrist, Jonathan
  • Chang, Ronald

Abstract

Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

21.

MVP CARTRIDGE AND METHODS OF USE AND MANUFACTURE

      
Application Number 18320837
Status Pending
Filing Date 2023-05-19
First Publication Date 2024-01-18
Owner Cepheid (USA)
Inventor
  • Yu, Rosa
  • Jones, Robert
  • Lopez, Jose
  • Wang, Jun
  • Bastin, Baback

Abstract

Test cartridges for performing multi-target assay panels, in particular multiplex vaginal panels (MVP) and methods of use and manufacture. Such cartridges can include a cartridge body having multiple chambers and rotatable valve assembly to facilitate controlled fluid flow, and various reagents and buffers to chemically lyse nucleic acids from multiple targets in MVP. Specialized valve assemblies have been utilized to resist alkaline lysing buffers required to chemically lyse multiple targets, including various protozoa, yeasts and bacteria, including Atopobium spp. (Atopobium vaginae, Atopobium novel species CCUG 55226); Bacterial Vaginosis-Associated Bacterium 2 (BVAB2); and Megasphaera-1. Methods include detecting levels of each respective target in a single sample from a single multi-target assay cartridge and identifying the subject as having bacterial vaginosis, vulvovaginal candidiasis (or the presence of Candida spp.), or trichomoniasis (or presence of Trichomonas vaginalis) based on detected levels of each of: Atopobium spp., BVAB2, Megasphaera-1, Candida spp., and Trichomonas vaginalis.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
  • C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

22.

ENCODERLESS MOTOR WITH IMPROVED GRANULARITY AND METHODS OF USE

      
Application Number 18341280
Status Pending
Filing Date 2023-06-26
First Publication Date 2023-12-28
Owner Cepheid (USA)
Inventor
  • Phan, Tien
  • Dority, Doug

Abstract

A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an angular position of the rotor relative the substrate to be determined from linear portions of the sinusoidal signal without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.

IPC Classes  ?

  • H02P 6/16 - Circuit arrangements for detecting position
  • H02K 29/08 - Motors or generators having non-mechanical commutating devices, e.g. discharge tubes or semiconductor devices with position sensing devices using magnetic effect devices, e.g. Hall-plates or magneto-resistors
  • H02K 1/2791 - Surface mounted magnets; Inset magnets
  • H02K 11/215 - Magnetic effect devices, e.g. Hall-effect or magneto-resistive elements
  • H02K 1/27 - Rotor cores with permanent magnets
  • H02K 11/00 - Structural association of dynamo-electric machines with electric components or with devices for shielding, monitoring or protection
  • H02K 15/02 - Methods or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of stator or rotor bodies

23.

MVP CARTRIDGE AND METHODS OF USE AND MANUFACTURE

      
Application Number US2023022995
Publication Number 2023/225362
Status In Force
Filing Date 2023-05-19
Publication Date 2023-11-23
Owner CEPHEID (USA)
Inventor
  • Yu, Rosa
  • Jones, Robert
  • Lopez, Jose
  • Wang, Jun
  • Bastin, Baback

Abstract

AtopobiumAtopobium vaginaeAtopobiumMegasphaeraCandidaTrichomonas vaginalisAtopobiumMegasphaeraCandida Trichomonas vaginalis Trichomonas vaginalis.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

24.

NUCLEIC ACID EXTRACTION AND ISOLATION WITH HEAT LABILE SILANES AND CHEMICALLY MODIFIED SOLID SUPPORTS

      
Application Number US2023020430
Publication Number 2023/212336
Status In Force
Filing Date 2023-04-28
Publication Date 2023-11-02
Owner CEPHEID (USA)
Inventor
  • Kutyavin, Alex I.
  • Lund, Kevin P.
  • Reed, Michael
  • Nakatani, Cameron J.
  • Nanassy, Oliver Z.
  • Leuzzi, Richard J.

Abstract

Compositions and methods for isolating and detecting nucleic acid in a biological sample are provided. The compositions and methods utilize a modified solid support comprising an amine or amide group.

IPC Classes  ?

  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

25.

DIAGNOSTIC DETECTION CHIP DEVICES AND METHODS OF MANUFACTURE AND ASSEMBLY

      
Application Number 18185754
Status Pending
Filing Date 2023-03-17
First Publication Date 2023-10-19
Owner Cepheid (USA)
Inventor Dority, Douglas B.

Abstract

Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • H01L 21/66 - Testing or measuring during manufacture or treatment

26.

UNITARY CARTRIDGE BODY AND ASSOCIATED COMPONENTS AND METHODS OF MANUFACTURE

      
Application Number US2023015311
Publication Number 2023/177748
Status In Force
Filing Date 2023-03-15
Publication Date 2023-09-21
Owner CEPHEID (USA)
Inventor Dority, Doug

Abstract

Improved sample cartridges, valve assemblies and methods of manufacture and assembly are provided herein. Such systems can include a sample processing cartridge having a unitary cartridge body with integral syringe tube and valve interface. Such systems can further includes valve assemblies with an overmolded gasket and gaskets with a protruding conical valve sealing surface. Various additional features can include thin film sealing for cartridge as well as valve assemblies for chemical lysis. Thin film sealing for cartridge lids can include various multi-layered designs to facilitate injection and sealing of reagents within the cartridge. Magnetic separation features are also included. Such features can be included in various design iterations as needed for compatibility with existing technologies and to accommodate needs for manufacturing workflows.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

27.

EXPONENTIAL BASE-GREATER-THAN-BASE 2 NUCLEIC ACID AMPLIFICATION USING HIGH- AND LOW-TM PRIMERS

      
Application Number US2023013057
Publication Number 2023/158644
Status In Force
Filing Date 2023-02-14
Publication Date 2023-08-24
Owner CEPHEID (USA)
Inventor Lokhov, Sergey G.

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification. The method employs pairs of primers that differ significantly in Tm and a novel temperature/time course characterized by a temperature pulse during denaturation that enables a high-Tm primer (but not a low-Tm primer) to anneal and prime the synthesis of an additional nucleic acid strand beyond the two strands synthesized in a cycle of classical PCR. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

28.

RFID KANBAN SYSTEM AND METHODS OF USE

      
Application Number 18067589
Status Pending
Filing Date 2022-12-16
First Publication Date 2023-06-22
Owner Cepheid (USA)
Inventor
  • Visagamani, Jayaprakash
  • Yanimineni, Suneetha

Abstract

RFID-based operations management systems and methods are provided herein, particularly RFID based Kanban systems. Such system can realize increased efficiencies, improved visibility of inventory throughout the workflow and improved response to variations in demand. RFID based solutions can automatically transact consumption of Kanban inventory in real-time and trigger replenishment signals to warehouses automatically, resulting in increased Kanban inventory accuracy and lower manual efforts for replenishment and consumption posting. This approach can interface with existing operational management software (e.g. ERP systems, such as SAP) seamlessly integrating with product manufacturing workflows. Such systems are uniquely applicable to manufacture of biological testing kits, where demands fluctuate considerably in response to crises, disasters, epidemics and pandemics.

IPC Classes  ?

  • G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
  • G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips

29.

Remote monitoring of medical devices

      
Application Number 18166901
Grant Number 11967403
Status In Force
Filing Date 2023-02-09
First Publication Date 2023-06-15
Grant Date 2024-04-23
Owner Cepheid (USA)
Inventor Steuperaert, Jan

Abstract

A remote monitoring system for medical data collection can include a data-flagging process embeds authorization and settings information into a file containing the test results. Such data flagging can occur at a medical device or testing site, and may be based in policy settings received from a remote system. A file containing the test results can also include data category information that can be used to protect sensitive information by preventing such information from being communicated to the wrong server.

IPC Classes  ?

  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • H04L 9/40 - Network security protocols
  • H04L 43/06 - Generation of reports
  • H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

30.

PSEUDO-COMPLEMENTARY BASES IN GENOTYPING AND NUCLEIC ACID SEQUENCING

      
Application Number 17921582
Status Pending
Filing Date 2021-04-27
First Publication Date 2023-06-01
Owner Cepheid (USA)
Inventor
  • Higuchi, Russell
  • Wang, Nicholas

Abstract

Described herein are methods and compositions that make use of pseudo-complementary bases to reduce unwanted hybridization in assays to detect and/or quantify particular nucleotide sequences, as well as in nucleic acid sequencing protocols.

IPC Classes  ?

  • C12Q 1/6855 - Ligating adaptors
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6832 - Enhancement of hybridisation reaction
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

31.

MOLECULAR DIAGNOSTIC ASSAY SYSTEM

      
Application Number 18054729
Status Pending
Filing Date 2022-11-11
First Publication Date 2023-06-01
Owner Cepheid (USA)
Inventor
  • Dority, Douglas B.
  • Phan, Tien
  • Fromm, David
  • Casler, Jr., Richard J.
  • Dickens, Dustin
  • Morita, Stuart
  • Piccini, Matthew

Abstract

Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • H02P 27/06 - Arrangements or methods for the control of AC motors characterised by the kind of supply voltage using variable-frequency supply voltage, e.g. inverter or converter supply voltage using dc to ac converters or inverters
  • H02P 6/182 - Circuit arrangements for detecting position without separate position detecting elements using back-emf in windings
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

32.

COMPOSITIONS AND METHODS OF DIAGNOSING AND TREATING TUBERCULOSIS

      
Application Number 18049165
Status Pending
Filing Date 2022-10-24
First Publication Date 2023-05-04
Owner Cepheid (USA)
Inventor Södersten, Erik

Abstract

Compositions and methods for detecting Mycobacterium tuberculosis (MTB) infection in a patient suspected of being infected with MTB and for distinguishing active tuberculosis (ATB), incipient tuberculosis (ITB) or subclinical tuberculosis (STB) from latent tuberculosis and other pulmonary and infectious diseases are provided. The methods may also be used to monitor treatment responses of MTB infected patients. Changes in the expression level of genes are used to aid in the diagnosis, prognosis, and treatment of tuberculosis.

IPC Classes  ?

  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

33.

COMPOSITIONS AND METHODS OF DIAGNOSING AND TREATING TUBERCULOSIS

      
Application Number US2022078571
Publication Number 2023/070123
Status In Force
Filing Date 2022-10-24
Publication Date 2023-04-27
Owner CEPHEID (USA)
Inventor Södersten, Erik

Abstract

Compositions and methods for detecting mycobacterium tuberculosis (MTB) infection in a patient suspected of being infected with MTB and for distinguishing active tuberculosis (ATB), incipient tuberculosis (ITB) or subclinical tuberculosis (STB) from latent tuberculosis and other pulmonary and infectious diseases are provided. The methods may also be used to monitor treatment responses of MTB infected patients. Changes in the expression level of genes are used to aid in the diagnosis, prognosis, and treatment of tuberculosis.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

34.

EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH REDUCED AMPLIFICATION TIME

      
Application Number 17737880
Status Pending
Filing Date 2022-05-05
First Publication Date 2023-03-30
Owner Cepheid (USA)
Inventor Higuchi, Russell

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.

IPC Classes  ?

  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

35.

ECHO AMPLIFICATION: A COMPREHENSIVE SYSTEM OF CHEMISTRY AND METHODS FOR AMPLIFICATION AND DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES

      
Application Number US2022043702
Publication Number 2023/043951
Status In Force
Filing Date 2022-09-15
Publication Date 2023-03-23
Owner CEPHEID (USA)
Inventor
  • Johns, Glenn
  • Mcdowell-Buchanan, Carla, Maria
  • Baraznenok, Vera

Abstract

Described herein is a comprehensive novel amplification system that can employ novel nucleic acid constructs as blocked primers, such constructs including a target-specific region, wherein the target-specific region comprises a target-specific cleavage domain, and a universal adapter sequence located 5' of the target-specific region, wherein the universal adapter sequence comprises a non-natural nucleotide base. Also described is a fusion protein between a polymerase and an endonuclease, which is useful in this system, as well as related methods and kits.

IPC Classes  ?

36.

LED CHARACTERIZATION AND COMPENSATION METHODS AND SYSTEMS

      
Application Number 17821093
Status Pending
Filing Date 2022-08-19
First Publication Date 2023-02-23
Owner Cepheid (USA)
Inventor
  • Shah, Amish
  • Lee, Marissa
  • Koay, Jessica
  • Casler, Jr., Richard J

Abstract

Systems and methods for monitoring, characterizing and controlling operation of LEDs are provided herein. Methods includes measuring a voltage across the LED, and correlating the voltage to a junction temperature of the LED. This correlation can be used to improve operation of the LED by increasing the signal to noise ratio of the LED signal, characterize the LED by comparing to an I-V curve, control LED operation to compensate for LED degradation and avoid crosstalk, and/or to generally improve performance and life expectancy of the LED. Improved performance of the LED can include stabilizing the photon output during performance of an assay to provide a desired dye reporter signal required for the assay and/or reducing an intra-shot during of the LED output during the assay. System and device with control units configured to perform these methods are also described herein.

IPC Classes  ?

  • G01R 31/26 - Testing of individual semiconductor devices
  • G01N 21/76 - Chemiluminescence; Bioluminescence
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

37.

DIAGNOSTIC ASSAY INSTRUMENT COMPRISING STABILIZED LED ILLUMINATION UNIT AND CORRESPONDING METHOD

      
Application Number US2022040939
Publication Number 2023/023359
Status In Force
Filing Date 2022-08-19
Publication Date 2023-02-23
Owner CEPHEID (USA)
Inventor
  • Shah, Amish
  • Lee, Marissa
  • Koay, Jessica
  • Casler Jr., Richard J.

Abstract

Systems and methods for monitoring, characterizing and controlling operation of LEDs are provided herein. Methods include measuring a voltage (V) across a LED (1), and correlating the voltage (V) to a junction temperature of the LED (1). This correlation can be used to improve operation of the LED (1) by increasing the signal to noise ratio of the LED signal (5), characterize the LED (1) by comparing to an l-V curve, control LED operation to compensate for LED degradation and avoid crosstalk, and/or to generally improve performance and life expectancy of the LED (1). Improved performance of the LED (1) can include stabilizing the photon output (5) during performance of an assay to provide a desired dye reporter signal required for the assay and/or reducing an intra-shot during of the LED output (5) during the assay. System and device with control units (2) configured to perform these methods are also described herein.

IPC Classes  ?

  • G01N 21/64 - Fluorescence; Phosphorescence
  • H05B 45/14 - Controlling the intensity of the light using electrical feedback from LEDs or from LED modules

38.

Diagnostic assay system

      
Application Number 29751420
Grant Number D0978369
Status In Force
Filing Date 2020-09-21
First Publication Date 2023-02-14
Grant Date 2023-02-14
Owner Cepheid (USA)
Inventor
  • Chang, Ronald
  • Mote, Gregory
  • Montgomery, Steven M.

39.

HIGH-LEVEL MULTIPLEXING REACTION VESSEL, REAGENT SPOTTING DEVICE AND ASSOCIATED METHODS

      
Application Number 17811448
Status Pending
Filing Date 2022-07-08
First Publication Date 2023-02-09
Owner Cepheld (USA)
Inventor
  • Glass, Jennifer Lynn
  • Chen, Michael Quay
  • Dority, John Benjamin
  • Siegrist, Jonathan Philip
  • Wong, Joanna

Abstract

Reaction vessels, cartridges, devices and methods for facilitating high-level multiplexing are described herein. Such reaction vessels can include a planar frame defining a fluidic path between a first planar substrate and a second planar substrate, a fluidic interface is located at one end of the planar frame with a pair of fluidic ports, a well chamber and a pre-amplification chamber. Devices for spotting reagents in wells of high-level multiplexing reaction vessels and improved reagent solutions are also described herein.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

40.

UNIVERSAL ASSAY CARTRIDGE AND METHODS OF USE

      
Application Number 17855578
Status Pending
Filing Date 2022-06-30
First Publication Date 2023-02-09
Owner Cepheid (USA)
Inventor
  • Nanduri, Harika
  • Weitsman, Andrew
  • Glass, Jennifer Lynn
  • Wei, Michelle
  • Noyes, Tina

Abstract

Sample cartridge, valve assembly and processing methods for providing mechanical lysis, chemical lysis or both for a given fluid sample are provided herein. Such systems can include a sample processing cartridge having a valve assembly configured for transport of the processing of fluid sample within the sample cartridge. The valve assembly can include a valve body and cap that secure a filter therebetween and facilitate inflow of mechanical or chemical lysing agents as needed for a fluid sample. Assay workflows for performing both mechanical and chemical lysis of a fluid sample within the same workflow of a single universal sample cartridge are also provided.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/6844 - Nucleic acid amplification reactions

41.

HIGH-LEVEL MULTIPLEXING REACTION VESSEL, REAGENT SPOTTING DEVICE AND ASSOCIATED METHODS

      
Application Number US2022036567
Publication Number 2023/283452
Status In Force
Filing Date 2022-07-08
Publication Date 2023-01-12
Owner CEPHEID (USA)
Inventor
  • Glass, Jennifer Lynn
  • Chen, Michael Quay
  • Dority, John Benjamin
  • Siegrist, Jonathan Philip
  • Wong, Joanna

Abstract

Reaction vessels, cartridges, devices and methods for facilitating high-level multiplexing are described herein. Such reaction vessels can include a planar frame defining a fluidic path between a first planar substrate and a second planar substrate, a fluidic interface is located at one end of the planar frame with a pair of fluidic ports, a well chamber and a pre-amplification chamber. Devices for spotting reagents in wells of high-level multiplexing reaction vessels and improved reagent solutions are also described herein.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

42.

UNIVERSAL ASSAY CARTRIDGE AND METHODS OF USE

      
Document Number 03224143
Status Pending
Filing Date 2022-06-30
Open to Public Date 2023-01-05
Owner CEPHEID (USA)
Inventor
  • Nanduri, Harika
  • Weitsman, Andrew
  • Glass, Jennifer
  • Ibanez, Michelle Wei
  • Noyes, Tina

Abstract

Sample cartridge, valve assembly and processing methods for providing mechanical lysis, chemical lysis or both for a given fluid sample are provided herein. Such systems can include a sample processing cartridge having a valve assembly configured for transport of the processing of fluid sample within the sample cartridge. The valve assembly can include a valve body and cap that secure a filter therebetween and facilitate inflow of mechanical or chemical lysing agents as needed for a fluid sample. Assay workflows for performing both mechanical and chemical lysis of a fluid sample within the same workflow of a single universal sample cartridge are also provided.

IPC Classes  ?

  • C12M 1/32 - Inoculator or sampler multiple field or continuous type
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12M 1/26 - Inoculator or sampler
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 1/34 - Purifying; Cleaning

43.

UNIVERSAL ASSAY CARTRIDGE AND METHODS OF USE

      
Application Number US2022035859
Publication Number 2023/278798
Status In Force
Filing Date 2022-06-30
Publication Date 2023-01-05
Owner CEPHEID (USA)
Inventor
  • Nanduri, Harika
  • Weitsman, Andrew
  • Glass, Jennifer
  • Wei, Michelle
  • Noyes, Tina

Abstract

Sample cartridge, valve assembly and processing methods for providing mechanical lysis, chemical lysis or both for a given fluid sample are provided herein. Such systems can include a sample processing cartridge having a valve assembly configured for transport of the processing of fluid sample within the sample cartridge. The valve assembly can include a valve body and cap that secure a filter therebetween and facilitate inflow of mechanical or chemical lysing agents as needed for a fluid sample. Assay workflows for performing both mechanical and chemical lysis of a fluid sample within the same workflow of a single universal sample cartridge are also provided.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

44.

Command pod module

      
Application Number 29720274
Grant Number D0973655
Status In Force
Filing Date 2020-01-10
First Publication Date 2022-12-27
Grant Date 2022-12-27
Owner Cepheid (USA)
Inventor
  • Chang, Ronald
  • Montgomery, Stephen M.
  • Mote, Gregory E.

45.

THERMOSTABLE POLYMERASE INHIBITOR COMPOSITIONS AND METHODS

      
Application Number 17687473
Status Pending
Filing Date 2022-03-04
First Publication Date 2022-12-08
Owner Cepheid (USA)
Inventor
  • Lokhov, Sergey G.
  • Gall, Alexander A.
  • Baraznenok, Vera
  • Viazovkina, Ekaterina V.
  • Shishkina, Irina
  • Persing, David H.

Abstract

The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.

IPC Classes  ?

  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/686 - Polymerase chain reaction [PCR]

46.

MULTI-CHAMBERED LID APPARATUS WITH REAGENT PORT

      
Application Number 17733903
Status Pending
Filing Date 2022-04-29
First Publication Date 2022-10-13
Owner Cepheid (USA)
Inventor
  • Jordan, Paul
  • Kurse, Rohan

Abstract

A lid apparatus for a multi-chambered container. The lid apparatus has a top-lid that is hingedly attached to a bottom-cap. The top-lid includes one or more openings for fluid filling multiple passages that extend from the bottom-cap. A lower bottom-cap includes welding features for welding to the multi-chambered container. The bottom-cap further includes one or more auxiliary ports for injecting a reagent when the lid apparatus is in a closed configuration sealingly attached to the multi-chambered sample container.

IPC Classes  ?

  • B65D 47/08 - Closures with discharging devices other than pumps with discharge nozzles or passages having articulated or hinged closures
  • B65D 43/02 - Removable lids or covers
  • B65D 25/04 - Partitions
  • B65D 51/18 - Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
  • B65D 47/00 - Closures with filling and discharging, or with discharging, devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

47.

COMPOSITIONS AND METHODS FOR DISCRIMINATING BACTERIAL AND VIRAL INFECTIONS IN A HUMAN SUBJECT

      
Application Number 17576307
Status Pending
Filing Date 2022-01-14
First Publication Date 2022-09-22
Owner Cepheid (USA)
Inventor
  • Wallace, Stacey
  • Baig, Rebekah Gonzalez
  • Lu, Xixi
  • Kaldate, Rajesh

Abstract

The present disclosure is directed to methods and kits for discriminating between a bacterial infection and viral infection in a human subject. More specifically, the methods can comprise detecting the expression level of a combination of ABL1, IRF9, ITGAM, LY6E, PSTPIP2 and RUNX1 in biological samples from the human subject and determining whether the human subject has a bacterial or viral infection based on those expression levels.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

48.

METHODS FOR DISCRIMINATING BACTERIAL AND VIRAL INFECTIONS IN A HUMAN SUBJECT

      
Application Number US2022012462
Publication Number 2022/197351
Status In Force
Filing Date 2022-01-14
Publication Date 2022-09-22
Owner CEPHEID (USA)
Inventor
  • Wallace, Stacey
  • Baig, Rebekah Gonzalez
  • Lu, Xixi
  • Kaldate, Rajesh

Abstract

The present disclosure is directed to methods and kits for discriminating between a bacterial infection and viral infection in a human subject. More specifically, the methods can comprise detecting the expression level of a combination of ABL1, IRF9, ITGAM, LY6E, PSTPIP2 and RUNX1 in biological samples from the human subject and determining whether the human subject has a bacterial or viral infection based on those expression levels.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

49.

Methods of Detecting Trichomonas Vaginalis

      
Application Number 17743698
Status Pending
Filing Date 2022-05-13
First Publication Date 2022-09-15
Owner Cepheid (USA)
Inventor
  • Wang, James
  • Alugupally, Sudhir
  • Yu, Rosa
  • Yousif, Sally

Abstract

Compositions and methods for detecting Trichomonas vaginalis are provided.

IPC Classes  ?

  • C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa

50.

Assay processing system

      
Application Number 29764092
Grant Number D0961111
Status In Force
Filing Date 2020-12-28
First Publication Date 2022-08-16
Grant Date 2022-08-16
Owner Cepheid (USA)
Inventor
  • Chang, Ronald
  • Montgomery, Steven M.
  • Mote, Gregory

51.

THERMAL CONTROL DEVICE AND METHODS UTILIZING TEMPERATURE DISTRIBUTION MODELING

      
Application Number 17574951
Status Pending
Filing Date 2022-01-13
First Publication Date 2022-08-11
Owner CEPHEID (USA)
Inventor
  • Lee, Marissa
  • Koay, Jessica
  • Rohrs, Charles
  • Solis, Earl
  • Piccini, Matthew
  • Casler, Jr., Richard J.

Abstract

Thermal control devices and methods to provide improved control, speed and efficiency in temperature cycling are provided herein. Such thermal control device and methods can include one or more active elements, such a thermoelectric cooler device, that is controlled by an algorithm that regulates a temperature distribution of an adjacent reaction-vessel according to a temperature distribution command trajectory and estimated reaction-vessel temperature distribution. Some embodiments include two active elements that are bilaterally applied to opposing sides of the reaction-vessel. In some embodiments, the estimated reaction-vessel temperature is determined based on a state of power electronics of the element and a temperature output of one or more sensors of a portion of the element and/or an ambient environment of the reaction-vessel. Methods of calibration of such systems utilizing a thermal calibrator as a proxy for the reaction-vessel are also provided herein.

IPC Classes  ?

  • G05D 23/19 - Control of temperature characterised by the use of electric means
  • F25B 21/02 - Machines, plants or systems, using electric or magnetic effects using Nernst-Ettinghausen effect
  • G01K 1/02 - Means for indicating or recording specially adapted for thermometers
  • G01K 13/024 - Thermometers specially adapted for specific purposes for measuring temperature of moving fluids or granular materials capable of flow of moving gases
  • G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • B01L 1/02 - Air-pressure chambers; Air-locks therefor

52.

LOSSY MECHATRONIC SYSTEMS AND METHODS OF ESTIMATION

      
Application Number 17575009
Status Pending
Filing Date 2022-01-13
First Publication Date 2022-08-11
Owner CEPHEID (USA)
Inventor
  • Nerkar, Rajesh
  • Chimni, Amrita
  • Liu, Yajing
  • Vegiraju, Janaki-Rama
  • Casler, Ricahard J.

Abstract

Methods and systems for estimating force and motor torque in a mechatronic system are provided herein. Such methods and system are suited for improved control of small-scale mechatronic system, particularly a syringe, valve, and cartridge loader or door opening/closing mechanism of a diagnostic assay system. The methods can compensate for friction and account for various second-order effects, thereby allowing for more accurate pressure estimation, thereby allowing improved syringe operation. The methods can further allow for improved estimation of force or motor torque to allow for improved control of an actuatable valve interfacing the sample cartridge and cartridge loader or door opening/closing system. Methods of calibrating such systems are also provided.

IPC Classes  ?

  • A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
  • A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters

53.

INHIBITION OF DNA POLYMERASES BY URACIL-DNA GLYCOSYLASE-CLEAVABLE OLIGONUCLEOTIDE LIGANDS

      
Application Number 17688276
Status Pending
Filing Date 2022-03-07
First Publication Date 2022-08-11
Owner Cepheid (USA)
Inventor
  • Kutyavin, Igor V.
  • Lokhov, Sergey G.

Abstract

Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising modifying the aptamer by uracil-DNA glycosylase enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture. Mixtures for use in methods of the invention are also provided. In some aspects, the oligonucleotide aptamers are circular and comprise one or more deoxyuridine nucleotides providing for aptamer-specific recognition and modification of the circular aptamer by the uracil-DNA glycosylase enzymatic activity. Exemplary oligonucleotide aptamers, mixtures and methods employing uracil-DNA glycosylase enzymatic activity are provided. The methods can be practiced using kits comprising a DNA polymerase-binding oligonucleotide aptamer and at least one uracil-DNA glycosylase enzymatic activity having oligonucleotide aptamer-specific recognition to provide for specific modification of the aptamer by the uracil-DNA glycosylase enzymatic activity.

IPC Classes  ?

  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12N 9/99 - Enzyme inactivation by chemical treatment
  • C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)

54.

Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands

      
Application Number 17715815
Grant Number 11970717
Status In Force
Filing Date 2022-04-07
First Publication Date 2022-08-11
Grant Date 2024-04-30
Owner Cepheid (USA)
Inventor
  • Kutyavin, Igor V.
  • Lokhov, Sergey G.

Abstract

Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising cleaving the aptamer by endonuclease V enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture. Mixtures for use in methods of the invention are also provided. The oligonucleotide aptamers of the present invention are circular and comprise one or more deoxyinosine nucleotides providing for aptamer-specific recognition and cleavage of the circular aptamer by the endonuclease V enzymatic activity. Exemplary oligonucleotide aptamers, mixtures and methods employing endonuclease V enzymatic activity are provided. The methods can be practiced using kits comprising a DNA polymerase-binding oligonucleotide aptamer and at least one endonuclease V enzymatic activity having oligonucleotide aptamer-specific recognition to provide for specific cleavage of the aptamer by the endonuclease V enzymatic activity.

IPC Classes  ?

  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 9/22 - Ribonucleases
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

55.

INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE

      
Application Number 17586645
Status Pending
Filing Date 2022-01-27
First Publication Date 2022-07-21
Owner Cepheid (USA)
Inventor
  • Lai, Edwin Wei-Lung
  • Kohlway, Andrew
  • Van Atta, Reuel
  • Higuchi, Russell
  • Gall, Alexander A.
  • Kocmond, Kriszten

Abstract

Methods of determining methylation of DNA are provided. In one illustrative, but non-limiting embodiment the method comprises i) contacting a biological sample comprising a nucleic acid to a first matrix material comprising a first column or filter where said matrix material binds and/or filters nucleic acids in said sample and thereby purifies the DNA; ii) eluting the bound DNA from the first matrix material and denaturing the DNA to produce eluted denatured DNA; iii) heating the eluted DNA in the presence of bisulfite ions to produce a deaminated nucleic acid; iv) contacting said deaminated nucleic acid to a second matrix material comprising a second column to bind said deaminated nucleic acid to said second matrix material; v) desulphonating the bound deaminated nucleic acid and/or simultaneously eluting and desulphonating the nucleic acid by contacting the deaminated nucleic acid with an alkaline solution to produce a bisulfite converted nucleic acid; vi) eluting said bisulfite converted nucleic acid from said second matrix material; and vii) performing methylation specific PCR and/or nucleic acid sequencing, and/or high resolution melting analysis (HRM) on said bisulfite-converted nucleic acid to determine the methylation of said nucleic acid, wherein at least steps iv) through vi) are performed in a single reaction cartridge.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/686 - Polymerase chain reaction [PCR]

56.

THERMAL CONTROL DEVICE AND METHODS UTILIZING TEMPERATURE DISTRIBUTION MODELING

      
Application Number US2022012275
Publication Number 2022/155304
Status In Force
Filing Date 2022-01-13
Publication Date 2022-07-21
Owner CEPHEID (USA)
Inventor
  • Lee, Marissa
  • Koay, Jessica
  • Solis, Earl
  • Piccini, Matthew
  • Casler Jr., Richard J.

Abstract

Thermal control devices and methods to provide improved control, speed and efficiency in temperature cycling are provided herein. Such thermal control device and methods can include one or more active elements, such a thermoelectric cooler device, that is controlled by an algorithm that regulates a temperature distribution of an adjacent reaction-vessel according to a temperature distribution command trajectory and estimated reaction-vessel temperature distribution. Some embodiments include two active elements that are bilaterally applied to opposing sides of the reaction-vessel. In some embodiments, the estimated reaction-vessel temperature is determined based on a state of power electronics of the element and a temperature output of one or more sensors of a portion of the element and/or an ambient environment of the reaction-vessel. Methods of calibration of such systems utilizing a thermal calibrator as a proxy for the reaction-vessel are also provided herein.

IPC Classes  ?

  • G05D 23/19 - Control of temperature characterised by the use of electric means
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

57.

Methods of Detecting Influenza

      
Application Number 17693776
Status Pending
Filing Date 2022-03-14
First Publication Date 2022-07-21
Owner Cepheid (USA)
Inventor
  • Mokkapati, Anupama
  • Brown, Bradley
  • Jones, Robert

Abstract

Compositions and methods for detecting influenza are provided.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

58.

LOSSY MECHATRONIC SYSTEMS AND METHODS OF ESTIMATION

      
Application Number US2022012328
Publication Number 2022/155350
Status In Force
Filing Date 2022-01-13
Publication Date 2022-07-21
Owner CEPHEID (USA)
Inventor
  • Nerkar, Rajesh
  • Vegiraju, Janaki-Rama
  • Casler, Richard J.

Abstract

Methods and systems for estimating force and motor torque in a mechatronic system are provided herein. Such methods and system are suited for improved control of small-scale mechatronic system, particularly a syringe, valve, and cartridge loader or door opening/closing mechanism of a diagnostic assay system. The methods can compensate for friction and account for various second-order effects, thereby allowing for more accurate pressure estimation, thereby allowing improved syringe operation. The methods can further allow for improved estimation of force or motor torque to allow for improved control of an actuatable valve interfacing the sample cartridge and cartridge loader or door opening/closing system. Methods of calibrating such systems are also provided.

IPC Classes  ?

  • H02P 23/14 - Estimation or adaptation of motor parameters, e.g. rotor time constant, flux, speed, current or voltage
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • H02P 29/64 - Controlling or determining the temperature of the winding

59.

N PHASE POSITION ENCODER AND ASSOCIATED SIGNAL PROCESSING AND CALIBRATION METHODS

      
Application Number US2022012335
Publication Number 2022/155355
Status In Force
Filing Date 2022-01-13
Publication Date 2022-07-21
Owner CEPHEID (USA)
Inventor
  • Nerkar, Rajesh
  • Casler Jr., Richard J.

Abstract

An n phase encoder for use in a mechatronic system, including a movable element (104, 304) that applies a magnetic field with period S representing a total displacement, and a stationary support (201, 310) with n magnetic field sensors (202a-c, 312) mounted thereon and positioned on the stationary support (201, 310) so as to measure the magnetic field imparted by the movable element (104, 304), wherein n is greater than 1, the encoder being configured to obtain signals from the n magnetic field sensors (202a-c, 312) corresponding to the measurements of the magnetic field imparted by the movable element (104, 304), and to process n signals from the n magnetic field sensors (202a-c, 312) by utilizing a transformation matrix to determine a displacement of the movable element (104, 304), as well as associated signal processing and calibration methods.

IPC Classes  ?

  • G01D 5/244 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means generating pulses or pulse trains
  • G01D 5/14 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage
  • G01D 5/245 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means generating pulses or pulse trains using a variable number of pulses in a train

60.

ENCODERLESS MOTOR WITH IMPROVED QUANTIZATION AND METHODS OF USE AND CALIBRATION

      
Application Number 17575100
Status Pending
Filing Date 2022-01-13
First Publication Date 2022-07-14
Owner CEPHEID (USA)
Inventor
  • Davis, Jeffrey
  • Nerkar, Rajesh
  • Casler, Jr., Richard J.

Abstract

A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an angular position of the rotor to be determined from the sinusoidal signals by utilizing a transformation matrix or piece-wise algorithm applied in substantially linear portions of the sinusoidal signals without requiring use of additional hardware encoder or position sensors and without requiring noise-reduction or filtering of the signal.

IPC Classes  ?

  • H02P 6/16 - Circuit arrangements for detecting position

61.

Miscellaneous Design

      
Application Number 018895842
Status Pending
Filing Date 2022-07-11
Owner Cepheid (USA)
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing a website featuring scientific and technological information and advice in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment; scientific and technological consulting services in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment. Providing a website featuring medical information and advice in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment and laboratory equipment; medical consulting services in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment; medical diagnostic testing, monitoring and reporting services.

62.

DIAGNOSTIC ASSAY SYSTEM WITH REPLACEABLE PROCESSING MODULES AND REMOTE MONITORING

      
Document Number 03197077
Status Pending
Filing Date 2021-11-01
Open to Public Date 2022-05-05
Owner CEPHEID (USA)
Inventor
  • Chang, Ronald
  • Montgomery, Steven
  • Mote, Gregory
  • Bliven, Brian

Abstract

A biological sample processing apparatus having an enclosure and a plurality of sample processing modules held within an enclosure with a tiltable graphical user interface screen. In one aspect, the individual modules that are readily removable for repair, replacement or upgrade. Each module is configured to be independently operable and readily inserted into the enclosure for connection with a processing unit of the enclosure. Each module can include quick-release mechanisms so that the module can be readily removed and replaced manually or with minimal tools through the front of the enclosure without requiring substantial or total disassembly of the module or entire enclosure. In another aspect, the user interface screen can display identifying information, such as a barcode, that can be scanned by a user's portable device so as to monitor the progress of an assay remotely.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

63.

DIAGNOSTIC ASSAY SYSTEM WITH REPLACEABLE PROCESSING MODULES AND REMOTE MONITORING

      
Application Number US2021057598
Publication Number 2022/094414
Status In Force
Filing Date 2021-11-01
Publication Date 2022-05-05
Owner CEPHEID (USA)
Inventor
  • Chang, Ronald
  • Montgomery, Steven
  • Mote, Gregory
  • Bliven, Brian

Abstract

A biological sample processing apparatus having an enclosure and a plurality of sample processing modules held within an enclosure with a tiltable graphical user interface screen. In one aspect, the individual modules that are readily removable for repair, replacement or upgrade. Each module is configured to be independently operable and readily inserted into the enclosure for connection with a processing unit of the enclosure. Each module can include quick-release mechanisms so that the module can be readily removed and replaced manually or with minimal tools through the front of the enclosure without requiring substantial or total disassembly of the module or entire enclosure. In another aspect, the user interface screen can display identifying information, such as a barcode, that can be scanned by a user's portable device so as to monitor the progress of an assay remotely.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

64.

DIAGNOSTIC ASSAY SYSTEM WITH REPLACEABLE PROCESSING MODULES AND REMOTE MONITORING

      
Application Number 17516084
Status Pending
Filing Date 2021-11-01
First Publication Date 2022-05-05
Owner Cepheid (USA)
Inventor
  • Chang, Ronald
  • Montgomery, Steven M.
  • Mote, Gregory E.
  • Bliven, Brian M.

Abstract

A biological sample processing apparatus having an enclosure and a plurality of sample processing modules held within an enclosure with a tiltable graphical user interface screen. In one aspect, the individual modules that are readily removable for repair, replacement or upgrade. Each module is configured to be independently operable and readily inserted into the enclosure for connection with a processing unit of the enclosure. Each module can include quick-release mechanisms so that the module can be readily removed and replaced manually or with minimal tools through the front of the enclosure without requiring substantial or total disassembly of the module or entire enclosure. In another aspect, the user interface screen can display identifying information, such as a barcode, that can be scanned by a user's portable device so as to monitor the progress of an assay remotely.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

65.

PCRPLUS

      
Application Number 218250500
Status Pending
Filing Date 2022-04-28
Owner Cepheid (USA)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

(1) Diagnostic reagents for scientific use; reagents and kits comprised primarily of reagents for scientific and research use in connection with the amplification, analysis, labeling and detection of nucleic acids (2) Medical diagnostic reagents; reagents and kits comprised primarily of reagents for medical, clinical, medical laboratory or medical diagnostic use in connection with the amplification, analysis, labeling and detection of nucleic acids (3) Laboratory equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples, nucleic acid amplifiers and optical detectors; Laboratory equipment, namely, instrument systems, comprised of apparatus for nucleic acid amplification, analysis, labeling and detection, software for use in preparing and processing biological samples, cartridges, sample preparation land reaction containers and reaction vessels for preparing and processing biological samples, sold as a unit; apparatus for nucleic acid amplification, analysis, labeling and detection; Laboratory equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification, and optical detection; Laboratory devices for detecting genetic sequences; Diagnostic apparatus for the detection of pathogens for laboratory or research use; Scientific and research apparatus and instruments, namely, genetic sequencers for use in genetic analysis; Apparatus for DNA and RNA testing for scientific research purposes; Data processing apparatus (4) Clinical and medical equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples, nucleic acid amplifiers and optical detectors; Clinical and medical equipment for diagnostic purposes, namely, instrument systems, comprised of apparatus for nucleic acid amplification, analysis, labeling and detection, software for use in preparing and processing biological samples, cartridges, sample preparation and reaction containers and reaction vessels for preparing and processing biological samples, sold as a unit; Clinical and medical equipment for diagnostic purposes, namely, apparatus for nucleic acid amplification, analysis, labeling and detection; Clinical and medical equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification, and optical detection; Clinical and medical diagnostic apparatus and instruments for detecting genetic sequences; Clinical and medical diagnostic apparatus for use in detecting pathogens; Clinical and medical diagnostic apparatus and instruments for use in genetic analysis; Apparatus for DNA and RNA testing for medical purposes; Clinical and medical diagnostic apparatus and instruments for the analysis of body fluids (1) Providing a website featuring information and advice in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment; Consulting services in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment; Analysis and evaluation of the goods of others to assure compliance with standards, industry standards, and objectively determinable standards; Analysis and evaluation of the services of others to assure compliance with standards, industry standards, and objectively determinable standards (2) Providing a website featuring information and advice in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment; Consulting services in the fields of laboratory testing, medical diagnostic testing, medical diagnostic equipment, and laboratory equipment; Medical diagnostic testing, monitoring and reporting services

66.

Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands

      
Application Number 17508379
Grant Number 11840728
Status In Force
Filing Date 2021-10-22
First Publication Date 2022-04-21
Grant Date 2023-12-12
Owner Cepheid (USA)
Inventor
  • Kutyavin, Igor V.
  • Lokhov, Sergey G.

Abstract

Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising cleaving the aptamer by endonuclease V enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture. Mixtures for use in methods of the invention are also provided. In some aspects, the oligonucleotide aptamer comprises one or more deoxyinosine nucleotides providing for aptamer-specific recognition and cleavage of the aptamer by the endonuclease V enzymatic activity. Exemplary oligonucleotide aptamers, mixtures and methods employing endonuclease V enzymatic activity are provided. The methods can be practiced using kits comprising a DNA polymerase-binding oligonucleotide aptamer and at least one endonuclease V enzymatic activity having oligonucleotide aptamer-specific recognition to provide for specific cleavage of the aptamer by the endonuclease V enzymatic activity.

IPC Classes  ?

  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12N 9/22 - Ribonucleases
  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

67.

LAB IN A CARTRIDGE

      
Application Number 1657556
Status Registered
Filing Date 2022-03-09
Registration Date 2022-03-09
Owner Cepheid (USA)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments

Goods & Services

Diagnostic reagents for scientific use; reagents and kits comprised primarily of reagents for scientific and research use in connection with the amplification, analysis, labeling and detection of nucleic acids. Medical diagnostic reagents; reagents and kits comprised primarily of reagents for medical, clinical, medical laboratory or medical diagnostic use in connection with the amplification, analysis, labeling and detection of nucleic acids. Laboratory equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification and optical detection; laboratory equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples. Medical equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification and optical detection; medical equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples.

68.

METHODS OF DIAGNOSING TUBERCULOSIS AND DIFFERENTIATING BETWEEN ACTIVE AND LATENT TUBERCULOSIS

      
Application Number US2021053594
Publication Number 2022/076428
Status In Force
Filing Date 2021-10-05
Publication Date 2022-04-14
Owner CEPHEID (USA)
Inventor Nygren, Malin

Abstract

Compositions and methods for detecting mycobacterium tuberculosis (MTB) infection in a patient suspected of being infected with mycobacterium tuberculosis and for distinguishing between active and latent tuberculosis infection are provided. The methods may also be used to monitor progression of MTB infection or to monitor treatment of MTB infected patients. Changes in the expression level of genes are used to aid in the diagnosis, prognosis and treatment of tuberculosis.

IPC Classes  ?

  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

69.

METHODS OF DIAGNOSING TUBERCULOSIS AND DIFFERENTIATING BETWEEN ACTIVE AND LATENT TUBERCULOSIS

      
Application Number 17494427
Status Pending
Filing Date 2021-10-05
First Publication Date 2022-04-07
Owner Cepheid (USA)
Inventor Nygren, Malin

Abstract

Compositions and methods for detecting Mycobacterium tuberculosis (MTB) infection in a patient suspected of being infected with Mycobacterium tuberculosis and for distinguishing between active and latent tuberculosis infection are provided. The methods may also be used to monitor progression of MTB infection or to monitor treatment of MTB infected patients. Changes in the expression level of genes are used to aid in the diagnosis, prognosis and treatment of tuberculosis.

IPC Classes  ?

  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
  • C12Q 1/6851 - Quantitative amplification

70.

LAB IN A CARTRIDGE

      
Application Number 218070600
Status Pending
Filing Date 2022-03-09
Owner Cepheid (USA)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments

Goods & Services

(1) Diagnostic reagents for medical-scientific research use; in vitro diagnostic reagents for scientific purposes; reagent kits comprising dna primers, polymerase, deoxynucleotide triphosphate, and buffers for use in biotechnology fields; reagents for scientific purposes for use in nucleic acid isolation and purification; diagnostic reagents for the amplification, analysis, labeling and detection of nucleic acids; reagents and kits comprised primarily of reagents for scientific and research use in connection with the amplification, analysis, labeling and detection of nucleic acids. (2) Medical diagnostic reagents; reagents and kits comprised primarily of reagents for medical, clinical, medical laboratory or medical diagnostic use in connection with the amplification, analysis, labeling and detection of nucleic acids. (3) Laboratory equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification and optical detection; laboratory equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples. (4) Medical equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification and optical detection; medical equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples.

71.

Miscellaneous Design

      
Serial Number 97263438
Status Registered
Filing Date 2022-02-11
Registration Date 2023-07-11
Owner Cepheid ()
NICE Classes  ?
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments

Goods & Services

Laboratory equipment for scientific, medical, and generic research, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples Clinical and medical equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples

72.

FLUORESCENT DYES

      
Document Number 03185976
Status Pending
Filing Date 2021-07-13
Open to Public Date 2022-01-20
Owner CEPHEID (USA)
Inventor
  • Lund, Kevin P.
  • Sergueev, Dmitri
  • Gall, Alexander

Abstract

Automated oligonucleotide synthesis-compatible fluorescent dye phosphoramidite compounds, solid supports, and labeled polynucleotides incorporating the compounds are provided. The compounds allow universal incorporation of the fluorescent label into any position of the polynucleotide.

IPC Classes  ?

  • C07D 491/02 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains two hetero rings
  • C09B 11/24 - Phthaleins containing amino groups
  • G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

73.

METHODS OF DETECTING SARS-COV-2, INFLUENZA, AND RSV

      
Application Number 17358523
Status Pending
Filing Date 2021-06-25
First Publication Date 2022-01-20
Owner Cepheid (USA)
Inventor
  • Chu, Victor
  • Lokhov, Sergey
  • Nanassy, Oliver
  • Leuzzi, Richard Joseph
  • Wang, Jun

Abstract

Compositions and methods for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A, influenza B, and respiratory syncytial virus (RSV) are provided.

IPC Classes  ?

  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

74.

NONIONIC POLYETHER SURFACTANTS

      
Application Number US2021041421
Publication Number 2022/015725
Status In Force
Filing Date 2021-07-13
Publication Date 2022-01-20
Owner CEPHEID (USA)
Inventor
  • Gall, Alexander, A.
  • Baraznenok, Ivan

Abstract

Non-ionic polyether surfactants with improved resistance to hydrolysis are provided.

IPC Classes  ?

75.

NONIONIC POLYETHER SURFACTANTS

      
Application Number 17374509
Status Pending
Filing Date 2021-07-13
First Publication Date 2022-01-20
Owner Cepheid (USA)
Inventor
  • Gall, Alexander A.
  • Baraznenok, Ivan

Abstract

Non-ionic polyether surfactants with improved resistance to hydrolysis are provided.

IPC Classes  ?

76.

Fluorescent dyes

      
Application Number 17374514
Grant Number 11807643
Status In Force
Filing Date 2021-07-13
First Publication Date 2022-01-20
Grant Date 2023-11-07
Owner Cepheid (USA)
Inventor
  • Lund, Kevin P.
  • Sergueev, Dmitri
  • Gall, Alexander

Abstract

Automated oligonucleotide synthesis-compatible fluorescent dye phosphoramidite compounds, solid supports, and labeled polynucleotides incorporating the compounds are provided. The compounds allow universal incorporation of the fluorescent label into any position of the polynucleotide.

IPC Classes  ?

  • C07D 491/052 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
  • C09B 11/24 - Phthaleins containing amino groups
  • C12Q 1/686 - Polymerase chain reaction [PCR]

77.

FLUORESCENT DYES

      
Application Number US2021041416
Publication Number 2022/015721
Status In Force
Filing Date 2021-07-13
Publication Date 2022-01-20
Owner CEPHEID (USA)
Inventor
  • Lund, Kevin, P.
  • Sergueev, Dmitri
  • Gall, Alexander

Abstract

Automated oligonucleotide synthesis-compatible fluorescent dye phosphoramidite compounds, solid supports, and labeled polynucleotides incorporating the compounds are provided. The compounds allow universal incorporation of the fluorescent label into any position of the polynucleotide.

IPC Classes  ?

  • C07D 491/02 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains two hetero rings
  • C09B 11/24 - Phthaleins containing amino groups
  • C09B 57/00 - Other synthetic dyes of known constitution
  • G01N 33/542 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

78.

Miscellaneous Design

      
Serial Number 97215987
Status Registered
Filing Date 2022-01-12
Registration Date 2024-04-16
Owner Cepheid ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing a website featuring information and advice in the fields of laboratory testing and the use of laboratory equipment Providing a website featuring information and advice in the fields of medical diagnostic testing and the use of medical diagnostic equipment

79.

Miscellaneous Design

      
Serial Number 97215994
Status Registered
Filing Date 2022-01-12
Registration Date 2024-04-16
Owner Cepheid ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing a website featuring information and advice in the fields of laboratory testing and the use of laboratory equipment Providing a website featuring information and advice in the fields of medical diagnostic testing and the use of medical diagnostic equipment

80.

Miscellaneous Design

      
Serial Number 97216001
Status Registered
Filing Date 2022-01-12
Registration Date 2024-04-16
Owner Cepheid ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing a website featuring information and advice in the fields of laboratory testing and the use of laboratory equipment Providing a website featuring information and advice in the fields of medical diagnostic testing and the use of medical diagnostic equipment

81.

Miscellaneous Design

      
Serial Number 97215975
Status Registered
Filing Date 2022-01-12
Registration Date 2024-04-16
Owner Cepheid ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing a website featuring information and advice in the fields of laboratory testing and the use of laboratory equipment Providing a website featuring information and advice in the fields of medical diagnostic testing and the use of medical diagnostic equipment

82.

METHODS OF DETECTING SARS-COV-2, INFLUENZA, AND RSV

      
Application Number US2021039082
Publication Number 2021/263101
Status In Force
Filing Date 2021-06-25
Publication Date 2021-12-30
Owner CEPHEID (USA)
Inventor
  • Chu, Victor
  • Lokhov, Sergey
  • Nanassy, Oliver
  • Leuzzi, Richard Joseph
  • Wang, Jun

Abstract

Compositions and methods for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A, influenza B, and respiratory syncytial virus (RSV) are provided.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

83.

METHODS OF DETECTING SARS-COV-2, INFLUENZA, AND RSV

      
Document Number 03183566
Status Pending
Filing Date 2021-06-25
Open to Public Date 2021-12-30
Owner CEPHEID (USA)
Inventor
  • Chu, Victor
  • Lokhov, Sergey
  • Nanassy, Oliver
  • Leuzzi, Richard Joseph
  • Wang, Jun

Abstract

Compositions and methods for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A, influenza B, and respiratory syncytial virus (RSV) are provided.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

84.

EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH CYCLING PROBE

      
Application Number 17240865
Status Pending
Filing Date 2021-04-26
First Publication Date 2021-12-30
Owner Cepheid (USA)
Inventor
  • Higuchi, Russell
  • Lokhov, Sergey G.
  • Le, Victoria
  • Pavlik, Benjamin
  • Wang, Gongbo

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification and signal detection using a cycling probe. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates

85.

Exponential base-greater-than-2 nucleic acid amplification

      
Application Number 17306761
Grant Number 11952621
Status In Force
Filing Date 2021-05-03
First Publication Date 2021-12-23
Grant Date 2024-04-09
Owner CEPHEID (USA)
Inventor Higuchi, Russell

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/686 - Polymerase chain reaction [PCR]

86.

UNIVERSAL DOCKING BAY AND DATA DOOR IN A FLUDIC ANALYSIS SYSTEM

      
Application Number 17321295
Status Pending
Filing Date 2021-05-14
First Publication Date 2021-12-16
Owner Cepheid (USA)
Inventor
  • Chang, Ron
  • Montgomery, Steven M.
  • Mote, Gregory E.

Abstract

An analytic system for carrying out a chemical assay, the system having a bay with an opening on one side, the bay of a size and shape to enclose a cartridge carrying sample material to be analyzed, one or more mechanisms within the bay through which the cartridge and or material within the cartridge is influenced, a door of a size to cover the opening, a securing mechanism associated with the bay and the door, by which the door is secured when closed.

IPC Classes  ?

  • H04N 5/225 - Television cameras
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

87.

THERMAL CONTROL DEVICE AND METHODS OF USE

      
Application Number 17338264
Status Pending
Filing Date 2021-06-03
First Publication Date 2021-11-25
Owner Cepheid (USA)
Inventor
  • Fromm, David
  • Phan, Tien
  • Piccini, Matthew

Abstract

Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.

IPC Classes  ?

  • F25B 21/04 - Machines, plants or systems, using electric or magnetic effects using Nernst-Ettinghausen effect reversible
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

88.

Multi-chambered lid apparatus

      
Application Number 17342370
Grant Number 11891219
Status In Force
Filing Date 2021-06-08
First Publication Date 2021-11-25
Grant Date 2024-02-06
Owner Cepheid (USA)
Inventor Jordan, Paul

Abstract

A lid apparatus for a multi-chambered container. The lid apparatus has a top-lid that is hingedly attached to a bottom-cap. The top-lid includes one or more openings for fluid filling multiple passages that extend from the bottom-cap. A lower bottom-cap includes welding features for welding to the multi-chambered container.

IPC Classes  ?

  • B65D 47/08 - Closures with discharging devices other than pumps with discharge nozzles or passages having articulated or hinged closures
  • B65D 47/00 - Closures with filling and discharging, or with discharging, devices
  • B65D 51/18 - Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B65D 25/04 - Partitions
  • B65D 43/02 - Removable lids or covers

89.

PCRPLUS

      
Serial Number 97125768
Status Pending
Filing Date 2021-11-15
Owner Cepheid ()
NICE Classes  ?
  • 42 - Scientific, technological and industrial services, research and design
  • 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing a website featuring information and advice in the fields of laboratory testing and the use of laboratory equipment Providing a website featuring information and advice in the fields of medical diagnostic testing and the use of medical diagnostic equipment

90.

Encoderless motor with improved granularity and methods of use

      
Application Number 17217926
Grant Number 11689125
Status In Force
Filing Date 2021-03-30
First Publication Date 2021-11-11
Grant Date 2023-06-27
Owner Cepheid (USA)
Inventor
  • Phan, Tien
  • Dority, Doug

Abstract

A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an angular position of the rotor relative the substrate to be determined from linear portions of the sinusoidal signal without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.

IPC Classes  ?

  • H02K 11/215 - Magnetic effect devices, e.g. Hall-effect or magneto-resistive elements
  • H02K 1/27 - Rotor cores with permanent magnets
  • H02K 11/00 - Structural association of dynamo-electric machines with electric components or with devices for shielding, monitoring or protection
  • H02K 15/02 - Methods or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of stator or rotor bodies
  • H02P 6/16 - Circuit arrangements for detecting position
  • H02K 29/08 - Motors or generators having non-mechanical commutating devices, e.g. discharge tubes or semiconductor devices with position sensing devices using magnetic effect devices, e.g. Hall-plates or magneto-resistors
  • H02K 21/22 - Synchronous motors having permanent magnets; Synchronous generators having permanent magnets with stationary armatures and rotating magnets with magnets rotating around the armatures, e.g. flywheel magnetos
  • H02K 1/2786 - Outer rotors

91.

EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH CYCLING PROBE

      
Document Number 03176983
Status Pending
Filing Date 2021-04-26
Open to Public Date 2021-11-04
Owner CEPHEID (USA)
Inventor
  • Higuchi, Russell
  • Lokhov, Sergey G.
  • Le, Victoria
  • Pavlik, Benjamin
  • Wang, Gongbo

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification and signal detection using a cycling probe. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.

IPC Classes  ?

  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

92.

PSEUDO-COMPLEMENTARY BASES IN GENOTYPING AND NUCLEIC ACID SEQUENCING

      
Document Number 03177139
Status Pending
Filing Date 2021-04-27
Open to Public Date 2021-11-04
Owner CEPHEID (USA)
Inventor
  • Higuchi, Russell
  • Wang, Nicholas

Abstract

Described herein are methods and compositions that make use of pseudo-complementary bases to reduce unwanted hybridization in assays to detect and/or quantify particular nucleotide sequences, as well as in nucleic acid sequencing protocols.

IPC Classes  ?

  • C12Q 1/6855 - Ligating adaptors
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

93.

EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH CYCLING PROBE

      
Application Number US2021029245
Publication Number 2021/222144
Status In Force
Filing Date 2021-04-26
Publication Date 2021-11-04
Owner CEPHEID (USA)
Inventor
  • Higuchi, Russell
  • Lokhov, Sergey G.
  • Le, Victoria
  • Pavlik, Benjamin
  • Wang, Gongbo

Abstract

Described herein are methods and compositions that provide highly efficient nucleic acid amplification and signal detection using a cycling probe. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.

IPC Classes  ?

  • C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

94.

PSEUDO-COMPLEMENTARY BASES IN GENOTYPING AND NUCLEIC ACID SEQUENCING

      
Application Number US2021029448
Publication Number 2021/222289
Status In Force
Filing Date 2021-04-27
Publication Date 2021-11-04
Owner CEPHEID (USA)
Inventor
  • Higuchi, Russell
  • Wang, Nicolas

Abstract

Described herein are methods and compositions that make use of pseudo-complementary bases to reduce unwanted hybridization in assays to detect and/or quantify particular nucleotide sequences, as well as in nucleic acid sequencing protocols.

IPC Classes  ?

  • C12Q 1/6855 - Ligating adaptors
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

95.

METHODS AND COMPOSITIONS FOR NUCLEIC ACID ISOLATION

      
Application Number 17269182
Status Pending
Filing Date 2019-08-16
First Publication Date 2021-10-21
Owner Cepheid (USA)
Inventor
  • Baraznenok, Vera
  • Kutyavin, Alex I.
  • Nanassy, Oliver Z.
  • Sergueev, Dmitri
  • Gall, Alexander A.

Abstract

Methods and compositions for isolation of nucleic acids from biological samples are provided.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

96.

METHODS AND APPARATUS FOR SEQUENTIAL AMPLIFICATION REACTIONS

      
Application Number 17130394
Status Pending
Filing Date 2020-12-22
First Publication Date 2021-09-16
Owner Cepheid (USA)
Inventor
  • Smith, Joseph H.
  • Persing, David H.
  • Wortman, Alan
  • Chang, Ronald
  • Swenson, David

Abstract

The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6851 - Quantitative amplification
  • C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

97.

LAB IN A CARTRIDGE

      
Serial Number 97029289
Status Pending
Filing Date 2021-09-15
Owner Cepheid ()
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments

Goods & Services

Diagnostic reagents for scientific use; reagents and kits comprised primarily of reagents for scientific and research use in connection with the amplification, analysis, labeling and detection of nucleic acids; Reagents and kits comprised primarily of reagents for clinical or medical laboratory use in connection with the amplification, analysis, labeling and detection of nucleic acids Medical diagnostic reagents; Reagents and kits comprised primarily of reagents for medical or medical diagnostic use in connection with the amplification, analysis, labeling and detection of nucleic acids Laboratory equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification, and optical detection; Laboratory equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples Medical diagnostic equipment, namely, a device for bioanalysis incorporating a cartridge for sample preparation, nucleic acid purification, nucleic acid amplification, and optical detection used in testing for the purpose of detecting and diagnosing medical conditions, diseases and disorders, genetic conditions, viruses, bacteria, and other pathogens; Medical diagnostic equipment, namely, reaction vessels, fluidic blocks for preparing and processing biological samples, cartridges for preparing and processing biological samples used in testing for the purpose of detecting and diagnosing medical conditions, diseases and disorders, genetic conditions, viruses, and bacteria, and other pathogens

98.

Graphical user interface device

      
Application Number 29688963
Grant Number D0929988
Status In Force
Filing Date 2019-04-25
First Publication Date 2021-09-07
Grant Date 2021-09-07
Owner Cepheid (USA)
Inventor Carlson, Richard

99.

Remote monitoring of medical devices

      
Application Number 17237192
Grant Number 11594309
Status In Force
Filing Date 2021-04-22
First Publication Date 2021-08-19
Grant Date 2023-02-28
Owner Cepheid (USA)
Inventor Steuperaert, Jan

Abstract

A remote monitoring system for medical data collection can include a data-flagging process embeds authorization and settings information into a file containing the test results. Such data flagging can occur at a medical device or testing site, and may be based in policy settings received from a remote system. A file containing the test results can also include data category information that can be used to protect sensitive information by preventing such information from being communicated to the wrong server.

IPC Classes  ?

  • G06F 15/173 - Interprocessor communication using an interconnection network, e.g. matrix, shuffle, pyramid, star or snowflake
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • H04L 43/06 - Generation of reports
  • H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
  • H04L 9/40 - Network security protocols
  • G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades

100.

Motor having integrated actuator with absolute encoder and methods of use

      
Application Number 17162605
Grant Number 11876479
Status In Force
Filing Date 2021-01-29
First Publication Date 2021-08-19
Grant Date 2024-01-16
Owner Cepheid (USA)
Inventor Phan, Tien

Abstract

A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with a first set of permanent magnets distributed radially about the rotor to facilitate rotation of the rotor and a second set of permanent magnets on the rotor to facilitate determination of an absolute position of the rotor. The motor further includes first and second set of sensors for detection of the magnets of the inner and outer rings. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an absolute position of the rotor relative the substrate to be determined from the sinusoidal signals without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.

IPC Classes  ?

  • H02P 7/025 - Arrangements for regulating or controlling the speed or torque of electric DC motors the DC motors being of the linear type the DC motors being of the moving coil type, e.g. voice coil motors
  • H02K 1/27 - Rotor cores with permanent magnets
  • H02K 1/2795 - Rotors axially facing stators the rotor consisting of two or more circumferentially positioned magnets
  • H02K 1/2791 - Surface mounted magnets; Inset magnets
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