The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.
A toy with a ring-shaped body having multiple sections each forming a portion of the ring-shaped body and each having a tubular base portion. At least a first tab projects radially outward from the tubular base portion of a first section of the multiple sections. Surface features protrude from at least one of the first tab and the tubular base portion of at least one of the multiple sections. At least a first pressure sensor is embedded in the first tab and operates to activate a first electrical device in response to pressure applied to the first tab exceeding a pressure threshold. Activation of the first electrical device produces light, or sound, or vibrates.
The electrocatalyst system that is configured to oxidize a methanol molecule using piezo-electrocatalysis includes a substrate and a piezoelectric semiconductor. The piezoelectric semiconductor is coupled to the substrate. The piezoelectric semiconductor includes a nanostructured semiconducting zinc oxide (ZnO) catalyst. The nanostructured semiconducting zinc oxide catalyst is characterized by a UV-ozone (UV-O3) treatment process. The electrocatalyst system may be provided in a methanol fuel cell.
A method of authenticating an item is disclosed which includes applying light to an item, wherein the item includes a random distribution of fluorescent particles disposed thereon, capturing one or more images from the item, generating a cryptographic pattern from the one or more captured images by a host processing system, communicating the cryptographic pattern to a remote processing system having a plurality of cryptographic keys in a database each uniquely associated with a corresponding item, comparing the cryptographic pattern with the plurality of cryptographic keys in the database, and communicating a positive evaluation for authentication to the host processing system if a match is found between one of the plurality of cryptographic keys and the communicated cryptographic pattern.
H04L 9/32 - Arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system
6.
IMAGE ENHANCEMENT USING TEXTURE MATCHING GENERATIVE ADVERSARIAL NETWORKS
One or more systems, devices, computer program products and/or computer-implemented methods of use provided herein relate to image enhancement using a generative adversarial network (GAN). The computer-implemented system can comprise a memory that can store computer-executable components. The computer-implemented system can further comprise a processor that can execute the computer-executable components stored in the memory, wherein the computer-executable components can comprise a training component that can train a discriminator of the GAN to score a texture of a CT image, wherein the texture can be derived from a difference of two conditionally independent estimates produced by a generator of the GAN by respectively processing two independent noisy samples of images.
The construction system includes a composition that includes Portland cement, nano-TiO2, and slag cement. The composition may also include water. The composition is cured via a CO2 curing process to produce a self-cleaning photocatalytic composite with lower carbon footprint and may be more economically manufactured than known cement-based photocatalytic composites. The unveiled synergistic effect of using slag cement and applying a CO2 curing process may reduce the porosity of the material and reduce the penetration of the pollutants that will accumulate in the surface. Thus, pollutants will be more exposed to UV light and decompose the pollutants in a greater rate. The construction system is self-cleaning in that water, such as from rainfall, may effectively clean the cured composition to reset the sequestering capabilities for the construction system to continue to remove toxic gases for the atmosphere.
A method and system for hand-object interaction dataset collection is described herein, which is configured to support user-specified collection of hand-object interaction datasets. Such hand-object interaction datasets are useful, for example, for training 3D hand and object pose estimation model. The method and system adopt a sequential process of first recording hand and object pose labels by manipulating a virtual bounding box, rather than a physical object. Naturally, hand-object occlusions do not occur during the manipulation of the virtual bounding box, so these labels are provided with high accuracy. Subsequently, the images are separately captured of the hand-object interaction with the physical object. These images are paired with the previously recorded hand and object pose labels.
G06F 3/04815 - Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06F 3/04842 - Selection of displayed objects or displayed text elements
G06F 3/04845 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range for image manipulation, e.g. dragging, rotation, expansion or change of colour
A safety vent assembly for a cylindrical battery may include a burst disk configured to open and at least partially define a vent in response to a thermal runaway of the battery. The safety vent assembly may further include a current collector and a positive terminal. A turbulence promoter may be defined on the current collector. Gas from inside the battery may pass through the turbulence promoter and the vent formed by the burst disk during thermal runaway.
H01M 50/213 - Racks, modules or packs for multiple batteries or multiple cells characterised by their shape adapted for cells having curved cross-section, e.g. round or elliptic
H01M 50/30 - Arrangements for facilitating escape of gases
H01M 50/358 - External gas exhaust passages located on the battery cover or case
H01M 50/559 - Terminals adapted for cells having curved cross-section, e.g. round, elliptic or button cells
11.
AUTHORING SYSTEMS AND METHODS FOR ENABLING BIDIRECTIONAL BINDING OF AUGMENTED REALITY WITH TOYS IN REAL-TIME
An augmented reality (AR) interaction authoring system is described. The AR interaction authoring system is configured to support the real-time creation of AR applications to support AR-enhanced toys. The design of the AR interaction authoring system enables bidirectional interactions between the physical-virtual space of toys and AR. The AR interaction authoring system allows intuitive authoring of AR animations and toys actuations through programming by demonstration, while referring to the physical toy for a contextual reference. Using a visual programming interface, users can create bidirectional interactions by utilizing users' input on toys to trigger AR animations and vice versa. A plug-and-play IoT toolkit is also disclosed that includes hardware to actuate common toys. In this way, users can effortlessly integrate toys into the virtual world in an impromptu design process, without lengthy electronic prototyping.
G06T 19/00 - Manipulating 3D models or images for computer graphics
A63F 13/577 - Simulating properties, behaviour or motion of objects in the game world, e.g. computing tyre load in a car race game using determination of contact between game characters or objects, e.g. to avoid collision between virtual racing cars
A63F 13/63 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor by the player, e.g. authoring using a level editor
A63F 13/655 - Generating or modifying game content before or while executing the game program, e.g. authoring tools specially adapted for game development or game-integrated level editor automatically by game devices or servers from real world data, e.g. measurement in live racing competition by importing photos, e.g. of the player
G06F 3/0346 - Pointing devices displaced or positioned by the user; Accessories therefor with detection of the device orientation or free movement in a 3D space, e.g. 3D mice, 6-DOF [six degrees of freedom] pointers using gyroscopes, accelerometers or tilt-sensors
G06F 3/04815 - Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
12.
DIGITAL TWIN AUTHORING AND EDITING ENVIRONMENT FOR CREATION OF AR/VR AND VIDEO INSTRUCTIONS FROM A SINGLE DEMONSTRATION
A system and method for multi-media instruction authoring is disclosed. The multi-media instruction authoring system and method provide a unified and efficient system that supports the simultaneous creation of instructional media in AR, VR, and video-based media formats by subject matter experts. The multi-media instruction authoring system and method require only a single demonstration of the task by the subject matter expert and does not require any technical expertise of the subject matter expert. The multi-media instruction authoring system and method incorporate a 3D editing interface for free hand, in-headset interaction to create 2D videos from 3D recordings, by exploring novel virtual camera interactions.
A perovskite-polymer composite comprising a perovskite and a polymer, wherein the polymer has a structural unit comprising a thiourea (—HN(C═S)NH—) fragment and a (—R1—O—R2—) fragment, wherein R1 and R2 are each independently a C1-C6 alkyl or a cycloalkyl linker; a mechanically robust and self-healable solar cell comprising same; and a method of making same.
NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH (Ireland)
Inventor
Siskind, Jeffrey Mark
Pearlmutter, Barak Avrum
Abstract
A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation.
G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
G06F 7/60 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radix; Computing devices using combinations of denominational and non-denominational quantity representations
G06F 11/36 - Preventing errors by testing or debugging of software
An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers.
F02P 23/04 - Other physical ignition means, e.g. using laser rays
F02K 9/95 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof characterised by starting or ignition means or arrangements
16.
TREATMENT OF INFECTIONS AND BIOFILM FORMATION USING A CELLULOSE SYNTHASE INHIBITOR
In one embodiment, the present application relates to methods and materials for weed control of a field of a crop plant using a cellulose biosynthesis inhibitor selected from the group consisting of ES20 and ES20-1 to ES20-9 of FIG. 1A. In another embodiment, the present disclosure relates to a method for treatment or prevention of an infection through inhibition of biofilm formation of microorganisms comprising the step of applying a therapeutic effective amount of a cellulose biosynthesis inhibitor selected from the group consisting of ES20 and ES20-1˜ES20-9 of FIG. 1A, or a salt thereof, in combination with one or more other commonly used antibiotics. A composition matter comprising said compounds and methods of use are within the scope of the present invention.
A01N 47/30 - Derivatives containing the group N—CO—N—aryl or N—CS—N—aryl
A01N 47/34 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the groups , e.g. biuret; Thio-analogues thereof; Urea-aldehyde condensation products
A01N 47/36 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the group N—CO—N directly attached to at least one heterocyclic ring; Thio-analogues thereof
A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
A61L 2/16 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
A shape-morphing fin includes a fixed portion, a multistable portion, a coupling portion, and a vibration source. The multistable portion functions as a negative stiffness element. The multistable portion is selectively movable between a first position and a second position. The movement between first position and the second position is configured to remove the ice formation from the structure. The coupling portion couples the fixed portion to the multistable portion. The vibration source is configured to produce a resonant vibration to engage the movement of the multistable portion from the first position to the second position.
In examples, an electronic device is provided. The electronic device includes a processor to receive an input image from an image sensor. The processor is also to scale a size of the input image to a programmed size. The processor is also to encode the scaled input image to provide a feature map having a fractional size of the scaled input image. The processor is also to process the feature map according to lite reduced atrous spatial pyramid pooling (LR-ASPP) to provide a LR-ASPP result. The processor is also to decode the LR-ASPP result to provide an image segmentation result.
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
20.
BIOACTIVE PEPTIDE MOLECULES DISCOVERED BY A COMBINATION OF BIOINFORMATICS TECHNIQUE AND CHEMICAL SYNTHESIS
The present disclosure teaches a method of treating a patient in need of therapeutic intervention with bioactive cyclic peptide molecules which are useful as antimicrobials, anticancer agents, antiparasitic, immunosuppressants, and others.
A state of battery testing system is disclosed which includes a charger, a load to be coupled across the battery's positive and negative terminals, a processer adapted to apply a predetermined voltage pulse across the battery's positive and negative terminals, apply the load to the battery, measure and log current through the load as Iexp, and establish a model based on establishing an initial estimation of state of the battery (θ0), and establishing a modeled state of battery (θi) based on a plurality of internal parameters of the battery. The model is adapted to output a model current through the load, inputting θ0 and the plurality of internal parameters of the model to thereby generate Imodel, generate an objective function (f) based on a comparison of Imodel and Iexp, and iteratively optimize θi, and output θoptimal based on the iterations.
G01R 31/36 - Arrangements for testing, measuring or monitoring the electrical condition of accumulators or electric batteries, e.g. capacity or state of charge [SoC]
G01R 31/367 - Software therefor, e.g. for battery testing using modelling or look-up tables
G01R 31/3842 - Arrangements for monitoring battery or accumulator variables, e.g. SoC combining voltage and current measurements
G01R 31/392 - Determining battery ageing or deterioration, e.g. state of health
22.
CERAMIC SCINTILLATING MATERIALS AND METHODS OF FABRICATION THEREOF
A method of fabricating a material is described. The method includes preparing a powder mixture including yttrium aluminum garnet doped with a fissionable isotope, grinding the powder mixture to form a first milled powder, drying the first milled powder, calcinating the first milled powder to form a calcinated powder, grinding the calcinated powder to form a second milled powder, drying the second milled powder, shaping the second milled powder to form a plurality of shaped material portions, and sintering the plurality of shaped material portions.
B22F 3/16 - Both compacting and sintering in successive or repeated steps
B22F 1/142 - Thermal or thermo-mechanical treatment
B22F 9/04 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from solid material, e.g. by crushing, grinding or milling
A woven structure includes thermoelectric ribbons interwoven with thread. Each thermoelectric ribbon includes a matrix of thermoelectric elements, the matrix having an insulating substrate that supports plural rows of thermoelectric elements, a plurality of conductive elements, and two terminals. The conductive elements form a series connection of the thermoelectric elements between the two terminals. A set of first conductive elements have a first temperature and a set of second conductive contacts have a second temperature lower than the first temperature when a first current flows in a first direction between the first matrix terminal and the second matrix terminal. The matrix is configured to form spaced-apart alternating stacks of the first conductive contacts and second conductive contacts. Each length of the yard or thread is interwoven such that it passes alternately under stacks of first conductive contacts and over stacks of second conductive contacts.
H10N 10/17 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the structure or configuration of the cell or thermocouple forming the device
D03D 1/00 - Woven fabrics designed to make specified articles
D03D 3/00 - Woven fabrics characterised by their shape
D03D 15/533 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads electrically conductive
24.
Simultaneous Multi-Slice MRSI Using Density Weighted Concentric Ring Acquisition
A method of performing magnetic resonance spectroscopic imaging (MRSI) includes transmitting a multi-slice excitation pulse through tissue, the multi-slice excitation pulse configured to generate multi-slice MRSI signals. The method also includes performing density weighted concentric ring acquisition on the multi-slice MRSI signals. The method further includes receiving the generated multi-slice MRSI signals in a plurality of sensors disposed in various locations around the tissue. Imaging data is reconstructed based on the acquired imaging signals. A representation of the data is displayed.
G01R 33/483 - NMR imaging systems with selection of signal or spectra from particular regions of the volume, e.g. in vivo spectroscopy
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/485 - NMR imaging systems with selection of signal or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information
The solvated metal particle-coating system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and/or hexamethylphosphoramide. The metal additive may include an alkali metal and/or an alkaline earth metal. The solvated metal additive within the polar outer-sphere electron transferring solvent may be used to coat a metal particle and/or a metalloid particle as a layer. As the polar outer-sphere electron transferring solvent evaporates, the solvated metal additive is coupled to the metal particle and/or the metalloid particle.
A system may provide an eco-feedback and gaming platform for home energy management. The system may generate daily energy scores for a plurality of households. The system may prepare a community energy conservation game in which community conservation goals and participation thresholds are generated. The system may execute the game by receiving time series date from each of the households and rewards the households for participating in achieving the community goal.
G06Q 30/0207 - Discounts or incentives, e.g. coupons or rebates
A63F 13/798 - Game security or game management aspects involving player-related data, e.g. identities, accounts, preferences or play histories for assessing skills or for ranking players, e.g. for generating a hall of fame
A63F 13/80 - Special adaptations for executing a specific game genre or game mode
METHODS, ALGORITHMS AND SYSTEMS FOR SUB-NANOSECOND DIGITAL SIGNAL PROCESSING OF PHOTOMULTIPLIER TUBE RESPONSE TO ENABLE MULTI-PHOTON COUNTING IN RAMAN SPECTROSCOPY
A computer-implemented method of determining the number of photons contributing to an output of a photonic sensor, including receiving an electrical signal from the photonic sensor proportional to a number of photons the photonic sensor detects at its input as a function of time, wherein the photonic sensor is calibrated such that a response of the photonic sensor to a single photon detected is in a waveform comprising an amplitude and time, wherein the product amplitude X time is statistically bounded, determining a probabilistic boundary between one or more of electrical, optical, and thermal sources of noise of the sensor, acquiring each response wave form from the sensor through analog-to-digital conversion with a resolution in amplitude and time corresponding to accuracy required in quantifying the response, storing each acquired response, individually, in real-time, or in buffered packets in digital form, determining the number of photons for a specific time resolved acquisition, and effecting a summation of the count of photon arrivals obtained based on amplitude evaluation from each specific time resolved acquisition, for all time resolved acquisitions performed in a given observation period, yielding the number of photon arrivals associated with the amplitude evaluation.
The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
29.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LOWE SYNDROME
A combination of active agents for the treatment of Lowe Syndrome (LS) comprising a RhoA inhibitor and a mTOR inhibitor; a pharmaceutical composition comprising the combination and a pharmaceutically acceptable carrier; a combination of pharmaceutical compositions in which one composition comprises a RhoA inhibitor and the other composition comprises a mTOR inhibitor; and a method of treating a patient for LS.
A61K 31/505 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
Apparatuses and methods for creating phobic and philic surfaces (for example, superphobic and superphilic surfaces) are disclosed. Embodiments include methods for determining a heat treatment technique that increases the likelihood that a uniformly etched surface with minimal pitting will be formed when the surface of a material is subject to etching. Additional embodiments include evaluating the PRE number of the material, performing an anodic polarization sweep of the material, evaluating the polarization curve (current vs. potential) for the material, performing different etching protocols depending on the range of values the PRE number of the material belongs, and/or pulsing the current applied to the material during the etching process. Additional embodiments include apparatuses and methods for predictably etching a surface (such as a surface of a metal alloy) of a material, which can include etching interior portions of a hollow work piece.
The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
An in-situ creep capsule for a nuclear reactor, and methods of using. The capsule has a modular design which allows it to be used to test multiple different types and sizes of specimens and to be adapted for use in various different nuclear reactor configurations. The capsule may include an integrated heat exchanger to cool measuring instrumentation, which allows the capsule to be used for gathering data in-situ in next generation reactors with higher temperatures while the reactor is running.
G21C 17/10 - Structural combination of fuel element, control rod, reactor core, or moderator structure with sensitive instruments, e.g. for measuring radioactivity, strain
G01D 5/22 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying inductance, e.g. by a movable armature differentially influencing two coils
The combustion system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and/or hexamethylphosphoramide. The metal additive may include an alkali metal and/or an alkaline earth metal. For instance, the metal additive may include lithium, sodium, aluminum, zirconium, titanium, yttrium, hafnium, and/or magnesium.
C06B 43/00 - Compositions characterised by explosive or thermic constituents not provided for in groups
C06B 33/00 - Compositions containing particulate metal, alloy, boron, silicon, selenium or tellurium with at least one oxygen supplying material which is either a metal oxide or a salt, organic or inorganic, capable of yielding a metal oxide
34.
SUPRAMOLECULAR ASSEMBLIES, COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
Supramolecular assemblies, compositions thereof, and methods for preparing and use the same are provided. The supramolecular assemblies comprise a trimeric variant of a GCN4 peptide capable of self-assembly and incorporating one or more guest molecules in a functional 3D native structure.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/52 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
C07K 14/395 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
35.
ETHER-BASED ELECTROLYTES FOR LITHIUM METAL BATTERIES, LITHIUM METAL BATTERIES, AND METHODS OF USE
Ether-based electrolytes for lithium metal batteries, lithium metal batteries, and methods of their use. Such an ether-based electrolyte includes a highly-nonpolar, nonfluorinated dipropyl ether (DPE) solvent that enhances the oxidation stability of a lithium metal battery. Such a lithium metal battery includes the ether-based electrolyte electrochemically coupling an anode and cathode of the battery.
H01M 10/0569 - Liquid materials characterised by the solvents
H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE) (USA)
Inventor
Low, Philip Stewart
Chu, Haiyan
Lu, Yingjuan June
Leamon, Christopher Paul
Wheeler, Ii, Leroy W.
Jensen, Michael C.
Matthaei, James
Abstract
The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
The invention generally relates to systems and methods that employ a novel wall shear stress (WSS) estimation method for 4D flow MRI. In certain embodiments, the invention provides systems and methods for determining Wall Shear Stress (WSS) with 4D flow Magnetic Resonance Imaging (MRI), that involve receiving 4D MRI flow data; calculating a velocity gradient (and optionally calculating the pressure field) from the 4D MRI flow data; correcting the velocity gradient (such as by using a spatial gradient of the pressure field to correct the velocity gradient), thereby producing a corrected velocity gradient; and determining a WSS from the corrected velocity gradient.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
An apparatus for large-scale dynamic imaging of a sample is described. The apparatus includes an optical detector, a light guide, a dichroic beam splitter, and a light source. The light guide includes a first portion and a second portion. The second defines a tapered shape such that a first diameter defined by a distal end of the second portion is smaller than a second diameter defined by a proximal end of the second portion. The dichroic beam splitter is positioned between the first portion and the second portion of the light guide. The light source is configured to direct a light beam through an external surface of the dichroic beam splitter. The dichroic beam splitter is configured to direct the light beam toward the second open end of the light guide and transfer the return emitted signal through the light guide to the optical detector.
Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.
F02K 7/10 - Plants in which the working-fluid is used in a jet only, i.e. the plants not having a turbine or other engine driving a compressor or a ducted fan; Control thereof characterised by having ram-action compression, i.e. aero-thermo-dynamic-ducts or ram-jet engines
40.
ASSAYS, KITS AND METHODS FOR DETECTION OF BOVINE RESPIRATORY DISEASE COMPLEX-ASSOCIATED PATHOGENS
Assays, kits, and methods that target and/or detect the presence of bovine respiratory complex (BRD)-associated pathogens in a sample. These assays, kits and methods can be portable and capable of providing fast (within 45 minutes) and accurate (at least 96%) results in the field, eliminating the need for a laboratory and other complex equipment.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
41.
METHODS OF PRODUCING CARBON/CARBON COMPOSITE PREFORMS AND CARBON/CARBON COMPOSITES FORMED THEREFROM
Methods of manufacturing carbon/carbon preforms and carbon/carbon composites formed therefrom. Such a method includes extruding a polymer composite material using an extrusion deposition additive manufacturing process to form a preform, and heating the preform via pyrolysis to form the carbon/carbon composite.
Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/702 - Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
In some examples, a computing device can include a processor resource and a non-transitory memory resource storing machine-readable instructions stored thereon that, when executed, cause the processor resource to: identify a plurality of regions within a captured document, determine a quantity of vertical transitions and horizontal transitions within the plurality of regions, and select an output resolution for the plurality of regions based on the quantity of vertical transitions and horizontal transitions within the plurality of regions.
H04N 1/00 - PICTORIAL COMMUNICATION, e.g. TELEVISION - Details thereof
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 30/414 - Extracting the geometrical structure, e.g. layout tree; Block segmentation, e.g. bounding boxes for graphics or text
An example device is described for facilitating polygon localization. In various aspects, the device can comprise a processor. In various instances, the device can comprise a non-transitory machine-readable memory that can store machine-readable instructions. In various cases, the processor can execute the machine-readable instructions, which can cause the processor to localize a polygon depicted in an image, based on execution of a deep learning pipeline. In various aspects, the deep learning pipeline can comprise a circular-softmax block.
The present application relates to a method of weed control for a crop field using a synergistic effect of two herbicides cellulosin and isoxaben. A composition matter together with said method comprising cellulosin and isoxaben is within the scope of the present invention.
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
A01N 47/34 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the groups , e.g. biuret; Thio-analogues thereof; Urea-aldehyde condensation products
46.
DIIODOHYDROXYQUINOLINE FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION
The present application generally relates to a method to treat a patient with a bacterial infection caused by Clostridium difficile. Particularly the method compromises the step of administering a therapeutically effective amount of diiodohydroxyquinoline, with or without one or more anti-infective agents, to the patient in need of relief from said infection. Methods of uses and composition matters are within the scope of this disclosure.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A first machine learning model is applied to an image of a person and a stationary object to generate a first intermediate image including a simplified pose representation of the person in the image corresponding to a pose of the person. A simplified representation of the stationary object in the image is added to the first intermediate image. The simplified representation includes key points of the stationary object in the image. A second machine learning model is applied to a second intermediate image corresponding to the first intermediate image to determine a state of the person relative to the stationary object in the image as either a first state or a second state.
The present disclosure generally relates to a method for reducing the toxicity of polymyxins as a therapeutic agent comprising the step of coadministration of an aminoglycoside; a method for improving the aerosolization of an aminoglycoside comprising the step of combination formulation with a polymyxin; and a process for manufacturing a dry powder composition comprising a polymyxin and aminoglycoside. Pharmaceutical compositions and methods of treatment for lung infections are within the scope of this invention.
The invention generally relates to systems and methods for analyzing operational status of an electronic instrument. In certain embodiments, the invention provides systems that include a sampling module that operable couples to an electronic instrument in a manner that the sampling module receives a vapor emitted from the electronic instrument, the sampling module comprising an ionization source and one or more mass analyzers to thereby produce a chemical signature of one or more analytes in the vapor; and an analysis module operable coupled to the sampling module to receive the chemical signature of the one or more analytes in the vapor and compare the received chemical signature to a database of known chemical signatures to thereby determine operational status of the electronic instrument.
A fluorescent single molecule emitter simultaneously transmits its identity, location, and cellular context through its emission patterns. A deep neural network (DNN) performs multiplexed single-molecule analysis to enable retrieving such information with high accuracy. The DNN can extract three-dimensional molecule location, orientation, and wavefront distortion with precision approaching the theoretical limit of information content of the image which will allow multiplexed measurements through the emission patterns of a single molecule.
The present invention generally relates to a process of nanoparticle formulations and its composition matter for systemic treatment of sepsis. In particular, this invention discloses a method for preparing tannic acid-ferric nanoparticles, optionally incorporating a component of vitamin D3, coated with zwitterionic chitosan (ZWC) and polymyxin B (PMB). The invention described herein also pertains to pharmaceutical compositions and methods for the treatment of sepsis.
A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
A conjugate comprising a ligand that targets a folate receptor linked to an acrolein scavenger drug; a composition comprising same; a method of using the conjugate or the composition to scavenge acrolein, alone or in further combination with other reactive aldehyde species, in a subject with neurotrauma; and a method of delivering an acrolein scavenger or an imaging agent to the central nervous system (CNS) of a patient with inflammation in the CNS.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
A61P 25/00 - Drugs for disorders of the nervous system
53.
TWO-DIMENSIONAL MASS SPECTROMETRY USING ION MICROPACKET DETECTION
The invention generally relates to two-dimensional mass spectrometry using ion micropacket detection. In certain aspects, the invention provides systems including a mass spectrometer having an ion trap and one or more detectors. The system includes a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to: apply one or more scan functions to the ion trap that excite a precursor ion and eject a product ion from the ion trap; and determine a secular frequency of the product ion by detecting micropackets of the product ion as the micropackets are ejected from the ion trap.
Compounds, compositions and methods for reducing off-target toxicity of T cells expressing a chimeric antigen receptor (CAR-T cells) and/or providing enhanced control of CAR-T cell activation, and methods of treating a subject and/or modifying CAR-T cell activity in a subject with cancer.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
55.
COMPOSITIONS AND METHODS TO INCREASE RESISTANCE TO PHYTOPHTHORA SOJAE IN SOYBEAN
Provided are compositions comprising polynucleotides encoding Rps genes, and soybean plants or soybean seeds comprising the compositions and exhibiting resistance to Phytophthora. Additionally, various methods for employing the polynucleotides to increase resistance to Phytophthora are also provided herein.
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
A direct reductive amination of aldehydes, ketones, and keto acids with trifluoroacetoxyborane-amines (TFAB-amines), which are mild reductive amination agents prepared by monoacetoxylation of borane-amines; Aromatic and aliphatic lactams are obtained via a tandem reductive amination-cycloamidation of keto acids using TFAB-amine.
C07C 209/28 - Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
C07C 213/02 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
C07D 295/023 - Preparation; Separation; Stabilisation; Use of additives
C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
C07D 207/267 - 2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
C07D 207/27 - 2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 211/76 - Oxygen atoms attached in position 2 or 6
C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 209/46 - Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
In some examples in accordance with the present description, an electronic device is provided. The electronic device includes an image sensor and a controller. The controller is to receive multiple images from the image sensor including respective foregrounds and backgrounds. The controller is also to segment the respective foregrounds from the backgrounds. The controller is also to combine the backgrounds to form a fused background. The controller is also to receive a new image including a new image foreground and a new image background. The controller is also to segment the new image foreground from the new image background.
A method of entangling photons in a distributed quantum-based communication system is disclosed which includes generating sets of entangled photon pairs between a plurality of remote nodes (Nodes Ai and Nodes Bi) and a central entangling node (Node C), wherein Nodes Ai and Bi are in both quantum communication and classical communication with Node C, wherein one photon of a first entangled photon pair set is transmitted Node Ai and one photon of a second entangled photon pair set is transmitted to Node Bi, each over the associated quantum channels, and performing Bell-state measurements between the other photon of the first entangled photon pair and the other photon of the second entangled photon pair, such that if the photons arrive at about same time having about same frequency, then the photon pairs are marked as being entangled.
A metal oxide semiconductor (MOS)-based power device includes a semiconductor region, drain and source electrodes, a gate electrode separated from the semiconductor region by SiO2, where the channel length (CHL) has a range of between about 0.6 μm and about 0.5 μm, the silicon dioxide has a corresponding thickness (tox) range of between about 5 nm to about 30 nm, where the CHL has a range of between about 0.5 μm and about 0.4 μm, the tox has a corresponding range of between about 5 nm to about 25 nm, where the CHL has a range of between about 0.4 μm and about 0.3 μm, the tox has a corresponding range of between about 5 nm to about 20 nm, where the CHL has a range of between about 0.3 μm and about 0.2 μm, the tox has a corresponding range of between about 5 nm to about 15 nm.
H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
H01L 29/739 - Transistor-type devices, i.e. able to continuously respond to applied control signals controlled by field effect
H01L 29/74 - Thyristor-type devices, e.g. having four-zone regenerative action
H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A method of eliminating a gilt from selection for breeding comprising (i) obtaining a vaginal lipidome profile from a gilt at around the time of weaning and (ii) using the vaginal lipidome profile to assign the gilt as probable fertile or infertile; a method of analyzing a lipidome profile of a gilt vaginal swab comprising (i) receiving a vaginal swab obtained from a gilt at around the time of weaning and (ii) analyzing, or having analyzed, lipids obtained from the vaginal swab, and (iii) determining, or having determined, decreases/increases in lipid levels compared to normal; and a kit for obtaining a vaginal swab from a gilt.
A nanodevice provides for electric-field control of magnon-QSD interactions. The nanodevice includes a ferroelectric substrate, a ferromagnetic material disposed over the ferroelectric substrate, and a nanodiamond including an ensemble of nitrogen-vacancy (NV) spins, each NV magnetically interfacing with the ferromagnetic material. An electric field is measured by applying a voltage across the ferroelectric substrate and the ferromagnetic material, changing a magnon excitation spectrum of the ferromagnetic material with respect to an electron spin resonance frequency of the ensemble of NV spins, and measuring a relaxation rate of the ensemble of NV spins.
Methods for forming micro- and/or nano-structures on the surfaces of a device and devices made thereby. The methods include exposing the surfaces of the device having an initial microstructure to an oxidizing environment at a first elevated temperature so as to form a first oxide scale on the device surfaces, exposing the first oxide scale to a reducing agent at a second elevated temperature so as to convert or partially convert the first oxide scale into a composite scale that includes a second oxide and a first metal, and exposing the composite scale to a dissolution agent that selectively dissolves part or all of the second oxide so as to yield a porous surface layer that includes the first metal.
A method for making an optically active P2-ligand precursor comprising converting D-xylose or a derivative thereof or D-glucose or a derivative thereof to the optically active P2-ligand precursor.
A direct current (DC) electrical panel (DC Combiner) is disclosed which includes a plurality of input pairs of positive and negative inputs, each input pair of the plurality of input pairs is configured to provide a positive DC input at a predefined voltage and a negative DC return, each positive input is coupled to a protection circuit whereby each such positive input is isolated from other positive inputs of the plurality of input pairs, thereby generating a protected input, each protected input is coupled to a busbar, and the busbar coupled to a plurality of switched circuits via a breaker switch in line with a protected input.
H02H 3/16 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to fault current to earth, frame or mass
67.
SYSTEMS AND METHODS FOR CONDUCTING REACTIONS AND SCREENING FOR REACTION PRODUCTS
Systems and methods for measuring web tension distribution in roll-to-roll processes, for example, such as R2R processes employed in the fabrication of printed devices. Such systems and methods entail a web that travels between first and second rollers in a longitudinal direction of the web, inducing tension in the web in the longitudinal direction thereof such that tension is present in a flexible substrate of the web between the first and second rollers, and operating the system to determine an average tension and linear variation of tension present in the flexible substrate resulting from the tension induced in the web inducing a nonuniform tension distribution in the flexible substrate between the first and second rollers. The systems and methods utilize one or more devices that induce deflection in the web between the first and second rollers.
G01L 5/04 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring tension in flexible members, e.g. ropes, cables, wires, threads, belts or bands
B65H 23/04 - Registering, tensioning, smoothing, or guiding webs longitudinally
In some examples in accordance with the present description, an electronic device is provided. The electronic device includes a controller to implement an image segmentation process. The controller is to obtain color information of an image. The controller also is to obtain depth information of the image. The controller also is to determine a depth of a face represented in the color information. The controller also is to segment a foreground of the image from a background of the image according to the color information and the depth information based on the depth of the face.
Systems and methods for measuring web tension distribution in roll-to-roll processes, for example, such as R2R processes employed in the fabrication of printed devices. Such systems and methods entail a web that travels between first and second rollers in a longitudinal direction of the web, inducing tension in the web in the longitudinal direction thereof such that tension is present in a flexible substrate of the web between the first and second rollers, and operating the system to determine an average tension and linear variation of tension present in the flexible substrate resulting from the tension induced in the web inducing a nonuniform tension distribution in the flexible substrate between the first and second rollers. The systems and methods utilize one or more devices that induce deflection in the web between the first and second rollers.
G01L 5/04 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring tension in flexible members, e.g. ropes, cables, wires, threads, belts or bands
B65H 23/04 - Registering, tensioning, smoothing, or guiding webs longitudinally
71.
PLANT CELL CHROMOSOME DOUBLING BY APPLICATION OF ELECTROMAGNETIC FIELD
Disclosed are methods for the doubling of a plant cell's chromosome by applying an electromagnetic field and methods for obtaining a doubled-haploid plant cell. In some embodiments, the plant cell is selected from the group comprising maize, rice, tomato, and tobacco. Also disclosed is an apparatus for applying an electromagnetic field to a plant cell.
The present disclosure relates to a stage-specific process for manufacturing a population of neutrophils, such as chimeric antigen receptor-expressing (CAR-expressing) neutrophils (e.g., T cells and natural killer (NK) cells), from human pluripotent stem cells (hPSCs) using defined media and related compositions, kits, and methods of use (e.g., targeted cancer immunotherapy). Stage-specific processes for generating neutrophils and chimeric antigen receptor (CAR) neutrophils from human pluripotent stem cells (hPSCs) using chemically defined, feeder-free platforms and stage-specific morphogens; cell lines; pharmaceutical compositions; a method of treating cancer; and a kit are within the scopes of this disclosure.
The present disclosure relates to adhesive compositions made from the reaction product of plant protein and phenolics, and method of making and using the adhesive compositions. A maximum bonding strength of 7.8±1.5 MPa was obtained using only 1 weight % tannic acid in a zein matrix of pH=7 and cured in 120° C.
A method of generating a computational model includes generating a set of benchmark parameters indicative of material properties of a reference material system through performance of at least one of a simulation of, or an experiment on, a subset of the reference material system, generating a plurality of DFTB parameters for the reference material system, performing an optimization routine to adjust each DFTB parameter of the plurality of DFTB parameters to improve accuracy relative to the set of benchmark parameters of the reference material system, and storing an optimized set of DFTB parameters corresponding to the material properties of the reference material system.
The United States of America, as Represented by the Secretary of Agriculture (USA)
Inventor
Field, Tyler C.
Neeno, Samantha Marie
Stwalley, Iii, Robert Merton
Schinkel, Allan P.
Johnson, Jay S.
Abstract
Devices and methods for monitoring internal physiological parameters of animals. Such a device and method makes use of a housing configured for implantation in an animal, and at least first and second arms pivotally coupled to the housing to have a collapsed configuration and a deployed configuration, wherein the first and second arms are alongside the housing and approximately parallel to the longitudinal axis in the collapsed configuration, expanded outward away from the housing and not parallel to the longitudinal axis in the deployed configuration, and biased toward the deployed configuration. Sensors are associated with the housing for collecting physiological parameters of the animal. The device is further equipped with a wireless transmitter for wirelessly transmitting outputs of the sensors to a receiver while the housing is implanted internally within the animal and the receiver is located externally of the animal.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
77.
INJECTION MANIFOLD WITH TESLA VALVES FOR ROTATING DETONATION ENGINES
A combustion method is disclosed, which includes the steps of mixing fuel and an oxidizer into a mixture, wherein fuel originates from a fuel manifold and the oxidizer originates from an oxidizer manifold, and combusting the mixture in a combustion chamber, the fuel manifold, the oxidizer manifold, and the combustion chamber forming parts of an injector assembly wherein each of the fuel and oxidizer manifolds communicates with the combustion chamber via a plurality of dedicated radially disposed Tesla valves around the combustion chamber each via a corresponding port with only one Tesla valve between the fuel manifold and the corresponding port on the combustion chamber and with only one Tesla valve between the oxidizer manifold and the corresponding port on the combustion chamber, wherein the plurality of Tesla valves substantially eliminate reverse flow of exhaust gases from the combustion chamber back to the fuel manifold or the oxidizer manifold.
F02C 5/02 - Gas-turbine plants characterised by the working fluid being generated by intermittent combustion characterised by the arrangement of the combustion chamber in the plant
F02K 7/067 - Plants in which the working-fluid is used in a jet only, i.e. the plants not having a turbine or other engine driving a compressor or a ducted fan; Control thereof the jet being intermittent, i.e. pulse jet with combustion chambers having valves having aerodynamic valves
78.
ELECTROCHEMICAL SENSOR SYSTEM AND METHOD FOR URIC ACID MEASUREMENT
An electrochemical sensor that includes a substrate and a piezoelectric semiconductor which is configured to detect uric acid using piezo-electrocatalysis. The piezoelectric semiconductor is coupled to the substrate. The piezoelectric semiconductor includes a nanostructured semiconducting ZnO catalyst. The nanostructured semiconducting ZnO catalyst has a noncentrosymmetric wurtzite configuration. The nanostructured semiconducting ZnO catalyst is shaped as a nanorod and/or a nanosheet.
A saliency map of an image is generated. Saliency regions of the saliency map are identified. The saliency regions are merged into a combined saliency region. Candidate image crops of the image are generated based on the combined saliency region. An image crop of the image is selected from the candidate image crops using a machine learning model.
G06V 10/771 - Feature selection, e.g. selecting representative features from a multi-dimensional feature space
G06V 10/77 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
80.
APPARATUSES AND METHODS FOR EXAMINING THE MOVEMENT OF CONSTITUENTS WITHIN TISSUE CELLS
Apparatuses and methods for investigating the inside of a tissue cell are disclosed. Embodiments include diffusely scattering light off a target sample, producing two crossing beams from the scattered light, and using a camera to create an image from the light. Some embodiments utilize a Fourier lens and a Fresnel biprism, and optionally include a long-coherence light source, a delay plate (which can be a polarization rotator or an optical flat), and/or a beam expander. Still further embodiments utilize a diffraction grating, a spatial filter (which may include two differently sized apertures), and a Fourier lens, and optionally include differently sized apertures in the spatial filter. Some embodiments include a transparent support and illuminating the target at an oblique angle through the transparent support. Still further embodiments utilize a low-coherence light source and/or immobilizing the sample tissue using surface bonding chemistry.
A method of generating a photon with multiple dimensions includes a step of generating a first photon encoded with quantum information in each of two or more frequency bins and at least one time bin. The method further includes performing a frequency dependent time operation to entangle (i.e. make non-separable) the frequency bins and the time bins in the photon.
The vibration attenuation system includes a load bearing layer, a non-load bearing layer, and a rigid beam connector. The load bearing layer has a first density and a first stiffness. The non-load bearing layer has a second density and a second stiffness. The second density is lower than the first density. The rigid beam connector has a third density and a third stiffness. The rigid beam connector couples the load bearing layer to the non-load bearing layer. The coupling of the non-load bearing layer to the load bearing layer is enabled through the use of the rigid beam connector which provides a nonlocal connection to transfer energy from the load bearing layer to the non-load bearing layer.
F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systems; Suppression of vibrations of rotating systems by use of members not moving with the rotating system
B32B 25/04 - Layered products essentially comprising natural or synthetic rubber comprising rubber as the main or only constituent of a layer, next to another layer of a specific substance
B32B 3/26 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a layer with cavities or internal voids
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
F16F 13/06 - Units comprising springs of the non-fluid type as well as vibration-dampers, shock-absorbers, or fluid springs comprising both a plastics spring and a damper, e.g. a friction damper the damper being a fluid damper, e.g. the plastics spring not forming a part of the wall of the fluid chamber of the damper
83.
SYSTEM AND METHOD FOR DILEMMA ZONE MITIGATION AT SIGNALIZED INTERSECTIONS
A system to reduce probability of a crash in an intersection is disclosed which includes one or more way-sensor systems, the one or more sensor systems adapted to provide position and velocity vector of an object approaching the intersection on an associated path, a processing unit including configured to: determine timing of the object with respect to a predefined zone of the intersection on the associated path, determine the current and future status of the associated traffic lights on the associated path of the object, predict timing of the object with respect to the predefined zone and future status of the associated traffic light, if timing prediction is within a predetermined threshold, modify the current status, wherein tgreen is extended, if timing prediction is outside of the predetermined threshold, modify the current status, wherein tgreen is reduced, and repeating above steps until the object has cleared the intersection.
A device for measuring and monitoring heart rate, respiration rate, and oxygen saturation of a subject is disclosed, which includes a biometric sensor board having a photosensor adapted to measure reflectance of red and infrared lights off skin tissue, wherein the biometric sensor board adapted to control one or more light emitting diodes (LEDs), wherein brightness of the LEDs are automatically adjusted to account for skin tone, thereby generating photoplethysmographic data, a processor unit adapted to analyze data measured by the biometric sensor board, and a display adapted to display results of the processed data remotely.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
In some examples, an electronic device comprises an interface to receive a video of a human face, a memory storing executable code, and a processor coupled to the interface and to the memory. As a result of executing the executable code, the processor is to receive the video from the interface, use a facial detection technique to produce a sequence of images of the human face based on the video, use a neural network to predict a photoplethysmographic (PPG) signal based on the sequence of images, convert the PPG signal to a frequency domain signal, and determine a heart rate by performing a frequency analysis on the frequency domain signal.
The multiwavelength ultrasound system includes a first ultrasound device, a second ultrasound device, and a processor. The multiwavelength ultrasound system aggregates and visualizes biological cells. The first ultrasound device is configured to produce a first ultrasound wave having a frequency lower than around 300 kHz. The first ultrasound wave is also configured to aggregate the biological cells. The second ultrasound device is configured to produce a second ultrasound wave having a frequency greater than around 300 kHz. The second ultrasound wave is also configured to visualize the biological cells by determining a location and/or a position of the biological cells. The processor is configured to selectively actuate at least one of the first ultrasound device and the second ultrasound device. The processor is configured to detect at least one of a density and/or a concentration of the biological cells.
Some examples provides a set of frameworks, process and methods aimed at enabling the expression and exploration of free-form and parametric 3D shape designs enabled through natural interactions with a hand-held mobile device acting as a controller for 3D virtual objects. A reference plane in a virtual space generated by the location of the mobile device may be used to select a 3D virtual object intersected by the reference plane. Positioning of the mobile device may also be used to control a pointer in the virtual space. In an example, the orientation of the mobile device may be detected by an accelerometer or gyroscope. In example, the position of the mobile device may be detected by a position sensor.
G06F 3/04883 - Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser using a touch-screen or digitiser, e.g. input of commands through traced gestures for inputting data by handwriting, e.g. gesture or text
G06F 3/04845 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range for image manipulation, e.g. dragging, rotation, expansion or change of colour
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
G06T 19/00 - Manipulating 3D models or images for computer graphics
G06F 3/0346 - Pointing devices displaced or positioned by the user; Accessories therefor with detection of the device orientation or free movement in a 3D space, e.g. 3D mice, 6-DOF [six degrees of freedom] pointers using gyroscopes, accelerometers or tilt-sensors
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
88.
DEVICES, SYSTEMS, AND METHODS FOR THE DETECTION OF A TARGET ANALYTE USING MAGNETIC FOCUS LATERAL FLOW IMMUNOASSAY TECHNIQUES
Devices, systems, and methods are provided for magnetic focus enhanced lateral flow assays. The devices and systems are ultrasensitive and provide for the visual detection of the presence or absence of one or more target analytes—which may include pathogens, proteins, or even molecules smaller than the foregoing—even when such analytes are only present in very limited amounts. The devices and systems include an immunostrip with a magnet positioned adjacent thereto, and magnetic probes specific to a target analyte that bind to the target analyte with specificity if present within a fluid sample to be tested. Methods are also provided for detecting one or more target analytes using magnetic focus, such methods including a step of controlling movement of a target analyte complex on an immunostrip incorporating a magnetic field, where such control slows a flow of the target analyte complex through a capture area on the immunostrip.
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
89.
FIBROBLAST ACTIVATION PROTEIN (FAP) - TARGETED ANTIFIBROTIC THERAPY
A compound of formula Fa-L-Ia (A) or Fa—Ia (B), wherein Fa is a fibroblast activation protein alpha (FAPα) targeting moiety, L is a linker, and Ia is an inhibitor of a signaling pathway necessary for fibrosis in cancer-associated fibroblasts (CAFs); a pharmaceutical composition comprising same; and methods for treating a tumor, a cancer or a fibrotic disease in a subject.
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A formulation to deter abuse of a drug by smoking comprising a physical barrier having properties to entrap the drug and thermal degradation products thereof. The physical barrier is in the form of an additive or a polymer network or a combination thereof.
The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
92.
METHODS FOR PRODUCING FUNCTIONALIZED CARBON NANOSHEETS AND ELECTROCHEMICAL ENERGY STORAGE CELLS WITH ELECTRODES FORMED THEREOF
Methods of producing functionalized carbon nanosheets capable of use as electrode materials in electrochemical energy storage cells, electrodes and electrode materials formed thereby, and electrochemical energy storage cells of sodium-ion batteries that utilize such electrodes and electrode materials. Such a method of producing functionalized carbon nanosheets includes preparing a solution containing dissolved glucose, mixing a quantity of NaCl crystals with the solution to form a mixture, drying the mixture to form a gel comprising NaCl crystals each having a layer of glucose thereon, heating the gel in an inert atmosphere to a processing temperature and for a duration sufficient to cause carbonization of the glucose and in situ functionalization with oxygen-containing functional groups, and removing the NaCl crystals to yield the functionalized carbon nanosheets.
A method of large-scale continuous roll-to-roll fabrication of cellulose nanocrystal (CNC) coatings with controlled anisotropy, and CNC-coated flexible substrates prepared thereby. An order parameter of 0.78 is observed in CNC-poly(vinyl alcohol) (CNC-PVA) coating systems at 70% CNC loadings.
C09D 11/106 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A virtual thermocouple system for non-invasively predicting product characteristics is disclosed, which includes one or more temperature sensing systems including a resistive network which includes a temperature sensing device comprising a plurality of negative temperature coefficient (NTC) thermistors, and a load resistor, a corresponding system-on-chip coupled to a corresponding resistive network and configured to i) power the corresponding resistive network, ii) receive corresponding signals from each NTC thermistor of the corresponding temperature sensing device, iii) process the signal associated with each NTC thermistor of the corresponding temperature sensing device and thus generate data associated with each NTC thermistor, and iv) transmitting the processed data, a power generating device configured to provide power to the corresponding system-on-chip, and a base stations adapted to i) receive the processed data from a corresponding system-on-chip, and ii) using a predefined model, and non-invasively translate the processed data to thermal characteristics of a product.
G01K 13/00 - Thermometers specially adapted for specific purposes
G01K 1/024 - Means for indicating or recording specially adapted for thermometers for remote indication
G01K 1/02 - Means for indicating or recording specially adapted for thermometers
G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor
G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
A turbine row for an axial or mixed-flow fluid machine may include an airfoil, having a leading edge, a trailing edge, a pressure surface and a suction surface. The turbine row may further include two endwalls, extending from upstream of the airfoil leading edge to downstream of the airfoil trailing edge. The endwalls may define an inlet upstream of the leading edge of the airfoil and an outlet downstream of the airfoil. The endwalls have a contoured geometry which provides an increase in channel height from the inlet to the outlet and guarantees a throat area larger than the area of the inlet.
An autonomous construction robotic system is disclosed which includes a processing unit, a robotic arm, the robotic arm is adapted to be coupled to a central attachment arm and thereby position the central attachment arm according to a plurality of degrees of freedom, a panel handling and fastening system, including a panel handling assembly coupled to the central attachment arm and adapted to pick and place a construction panel onto a framed structure within a construction zone, and a vision system adapted to provide visual information to the processing unit associated with the framed structure, wherein the processing unit processes the visual information to automatically determine placement position of the construction panel on the framed structure.
Methods of determining and controlling the deformability of ceramic materials, as a nonlimiting example, YSZ, particularly through the application of a flash sintering process, and to ceramic materials produced by such methods. Such a method includes providing a nanocrystalline powder of a ceramic material, making a compact of the powder, and subjecting the compact to flash sintering by applying an electric field and thermal energy to the compact.
C04B 35/48 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates
The present disclosure generally relates to a composition matter and a method for cancer treatment. In particular, a composition of soft, non-cationic nanocapsules, termed Nanosac, for systemic delivery of siRNA. Nanosac is produced by sequential attachment of siRNA and polydopamine on a sacrificial MSN core, followed by removal of the MSN. Encapsulating siRNA in the capsules, Nanosac avoids the issues common to cationic gene carriers, such as toxicity and non-specific protein binding while protecting siRNA from RNase. Nanosac entered tumor cells by caveolae-mediated endocytosis, likely via albumin recruited from serum, trafficked to the cytosol, and silenced target genes.
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
The present application generally relates to natural killer cells (NK) and genetically modified NK cells, methods of transformation, and methods of use in combination with other molecules for targeting cells of interest.
C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
100.
CAPACITIVE SENSORS AND METHODS AND APPARATUSES FOR PRODUCING CAPACITIVE SENSORS
Capacitive sensors and methods and apparatuses for producing capacitive sensors. Such a method includes printing a dielectric layer to include a poly(vinylidene fluoride) (PVdF) film so that the dielectric layer has oppositely-disposed first and second surfaces. First and second electrodes are provided on the first and second surfaces, respectively, of the dielectric layer. A corona poling apparatus for producing a capacitive sensor includes an anode having at least one electrically conductive ionizer needle, a cathode opposite and facing the anode with a distance therebetween, a sample location defined between the ionizer needle and the cathode wherein the sample location is configured to receive an object to be polarized, and a shield surrounding at least one of the anode, the ionizer needle, and the cathode. The shield focuses ions created during a corona discharge between the anode and the cathode toward the sample location.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
patents
