This disclosure relates to electrolyzer composite membranes, and in particular, to a composite membrane having at least two reinforcing layers comprising a microporous polymer structure and a surprisingly high resistance to piercing. The electrolyzer composite membranes have a recombination catalyst configured to be disposed closer to an anode than to a cathode in a membrane-electrode assembly (MEA). The disclosure also relates to membrane-electrode assemblies and electrolyzers comprising the membranes, and to method of manufacture of the membranes.
Described herein are encapsulation devices that include an inner layer, an outer layer, a cell containment layer positioned between the inner and outer layer, and structural elements disposed within the cell containment layer to separate the inner and outer layers by a separation distance. The structural elements define reservoir spaces for the retention of a biological moiety (such as cells) therein. The structural elements maintain a separation distance both under external compressive forces and under internal expansive forces, such as undergoing a geometric change in the encapsulation device or during crushing and subsequent expansion of the cell encapsulation device. In some embodiments, a reinforcing layer is positioned between the inner layer and the cell containment layer. In addition, the encapsulation device may include at least one configuration element. Methods of placing encapsulation devices in a body conduit intra-luminally, extra-luminally, and via an open surgical procedure are also disclosed.
A multibranch implantable device including a main body including a tubular element having wall defining a main lumen, the tubular element having a first end defining a first opening into the main lumen and a second end defining a second opening in the main lumen, the tubular element including at least one side branch portal defining an aperture through the wall between the first longitudinal end and the second longitudinal end of the tubular element and at least one secondary body defining a secondary lumen, the at least one secondary body operable to be deployed with a portion of the secondary body positioned in the at least one side branch portal of the main body.
The present disclosure describes implantable medical devices comprising covers, such as a balloon cover. Such devices can comprise a first layer of a porous polymeric material, such as ePTFE, surrounded by layers of a porous polymeric material having an imbibed elastomer, such as polyurethane. The cover can be used to assist in deployment of an expandable implant, such as a stent-graft, within the body of the patient.
A composite sorbent polymer composite article is disclosed for adsorption. The sorbent polymer composite article includes a sorbent and a flexible porous polymer, the sorbent polymer composite article having an adsorptive configuration in which the sorbent polymer composite article is configured to adsorb one or more components of a feed stream, and a desorptive configuration in which the sorbent polymer composite article is configured to remove one or more components from the sorbent polymer composite article.
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
A device for treating disease along a main vessel and at least one branch vessel extending from the main vessel includes a branch member for deployment in the branch vessel, the branch member having a branch lumen; and a main body for deployment in the main vessel. The main body has a generally tubular wall extending generally longitudinally between opposite first and second ends. The wall has an internal surface defining a main lumen and an opposite outer surface. The wall has a recessed portion that is recessed relative to the outer surface of the wall and positioned between the first and second ends of the main body. The main body has an opening formed in the recessed portion of the wall for receiving the branch member therethrough such that the branch lumen is in fluid communication with the main lumen.
Examples of an implantable conduit that is tubular in shape and has an inner lumen and an outer surface, the implantable conduit are disclosed. The implantable conduit includes a plurality of overlap elements including a first overlap element and a second overlap element positioned adjacent the first overlap element to define an adjacent pair of the plurality of overlap elements. The first overlap element overlaps onto the second overlap element to define an overlapping portion between an inward facing surface of the first overlap element and an outward facing surface of the second overlap element. The implantable conduit also includes a plurality of attachment features coupling the first overlap element to the second overlap element. The inward facing surface of the first overlap element and the outward facing surface of the second overlap element are separable at the overlapping portion by an external force to open an aperture in the overlapping portion between at least two of the plurality of attachment features such that the aperture defines a path between the inner lumen and outer surface of the implantable conduit. The path is sealed absent the external force.
A61F 2/88 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
This document provides implantable intraluminal stent graft medical devices. In some embodiments, the stent graft devices provided herein are implantable in bodily conduits that have side branches, and the stent graft devices are operable to allow the flow of fluids between the conduit and the side branches. In some embodiments, the walls of the stent graft devices provided herein include compliant channels which allow for fluid communication between the interior and the exterior of the stent graft devices. In some embodiments, the compliant channels are configured to inhibit or reduce tissue ingrowth, tissue bridging, and/or endothelialization.
A looped wire is provided for placing an endograft into a blood vessel. The looped wire comprising a flexible guidewire with one or more loops distributed along its length. The one or more loops have an inner diameter that is larger than the thickness of a suture or wire for threading the suture or wire through. The one or more loops is adapted for sliding along the suture or wire. Endograft system comprising the looped wire, and methods of using the looped wire are also provided.
Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
An improved medical device reduces the loss of longitudinal length during expansion of a stent-graft from a compressed state to an expanded state. For example, the stent-graft is placed over a cover that provides resistance to expansion of the balloon during inflation, which reduces longitudinal compressing forces exerted on the stent-graft.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a cord that is flexible and elongated defining a length. The cord may include a core having a porous surface and a porosity-reducing element on at least a portion of the core.
A61B 17/06 - Needles; Holders or packages for needles or suture materials
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A medical assembly includes a balloon expandable endoprosthesis comprising a plurality of ringed stent elements flexibly connected to each other via at least one flexible connector, the endoprosthesis being deployable from an undeployed state with an undeployed diameter to a deployed state with a deployed diameter. The medical assembly further includes a catheter assembly comprising a balloon, and a cover along the balloon. The endoprosthesis is coaxially located about the balloon and the cover. One or more portions of the balloon and the cover reach an intermediate diameter between the undeployed diameter and the deployed diameter in which the portions of the balloon and the cover are inflated by increasing an inflation pressure within the balloon and approximately maintained at about the intermediate diameter until the inflation pressure increases by at least 1 atmosphere to overcome a yield strength of the cover.
A61F 2/844 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A drainage device for draining a biological fluid from an eye to a tissue external to the eye is disclosed. The drainage device is implantable at least in part within a tissue of the eye. The drainage device includes: an open collapsible body portion having a first surface with a first porosity and a second surface with a second porosity that is greater than the first porosity, the second surface opposing the first surface; and a conduit having a first end fluidly coupled with the first surface and a second end insertable into the eye to facilitate a drainage of the biological fluid into the conduit. The second surface with the second porosity includes at least one ingrowth surface region for facilitating ingrowth of tissue external to the eye.
A catalytic membrane composite that includes porous supported catalyst particles durably enmeshed in a porous fibrillated polymer membrane is provided. The porous fibrillated polymer membrane may be manipulated to take the form of a tube, disc, or diced tape and used in multiphase reaction systems. The supported catalyst particles are composed of at least one finely divided metal catalyst dispersed on a porous support substrate. High catalytic activity is gained by the effective fine dispersion of the finely divided metal catalyst such that the metal catalyst covers the support substrate and/or is interspersed in the pores of the support substrate. In some embodiments, the catalytic membrane composite may be introduced to a stirred tank autoclave reactor system, a continuous flow reactor system, or a Parr Shaker reaction system and used to effect the catalytic reaction.
B01J 19/18 - Stationary reactors having moving elements inside
B01J 8/22 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium gas being introduced into the liquid
B01J 10/00 - Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles; Apparatus specially adapted therefor
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
C07C 209/36 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings
Through observation it has been determined that deployment of delivery sleeves may result in one or more portions of the deliver), sleeve extending beyond an end of the endoluminal device resulting in an overhang of material. The overhang may affect blood flow through the endoprosthesis or otherwise impact performance, including facilitating unwanted tissue growth. Various inventive concepts are provided for addressing (reducing or removing) constraining sheath overhang.
Systems and methods for increasing removal efficiency of at least one filter medium. In some embodiments, at least one oxidizing agent is introduced into the flue gas stream, so as to react SO2 with the at least one oxidizing agent to form sulfur trioxide (SO3), sulfuric acid (H2SO4), or any combination thereof. Some of the embodiments further include introducing ammonia (NH3) and or dry sorbent into the flue gas stream, so as to react at least some of the sulfur trioxide (SO3), at least some of the sulfuric acid (H2SO4), or any combination thereof, with the ammonia (NH3) and form at least one salt.
The present disclosure describes methods of making a sleeve comprising a conical frustum having first and second end profiles and a lumen there through for covering and constraining an expandable device, and apparatuses, systems, and assemblies comprising an expandable device and a sleeve having a frustoconical shape when the expandable device is at least partially expanded. The present disclosure further describes methods for deploying an expandable device in a patient comprising releasing a releasable seam disposed on a sleeve and everting the sleeve while retracting it from the expandable device.
A therapeutic device includes a pouch having opposed first and second ends and first and second composite layers extending between the opposed first and second ends. The first composite layer includes a first cell permeable layer extending between the opposed first and second ends and a first cell retentive layer extending between the opposed first and second ends. The pouch includes a reservoir formed between the first and second composite layers, contacting the first cell retentive layer, and at least one port in fluid communication with the reservoir. The therapeutic device further includes a removal element configured to operably engage the first end of the pouch, to cause the first end to be moveable towards the second end by eversion. In some embodiments, each of the first and second composite layers includes a plurality of wrinkles that are incrementally disengaged from a tissue to remove the therapeutic device atraumatically.
An improved DAC unit and process containing an adsorber structure comprising an array of adsorber elements with a support layer and on both sides thereof at least one sorbent layer and at least one protective layer comprising a microporous material disposed around the support layer and the sorbent layer, wherein the protective layer has greater hydrophobicity than the sorbent material, wherein the adsorber elements are parallel to each other and spaced apart forming parallel fluid passages for flow-through of ambient atmospheric air and/or desorbing media, the method comprising the following sequential and repeating steps: (a) adsorption by flow-through; (b) isolating said sorbent; (c) injecting a stream of desorbing media through said parallel fluid passages and inducing an increase of the temperature; (d) extracting desorbed carbon dioxide from the unit and separating it from desorbing media; (e) bringing the sorbent material to ambient temperature conditions.
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A medical device delivery system comprises an elongate member having a main lumen configured to contain a main guidewire and at least one secondary lumen configured to releasably contain a secondary guidewire, the secondary lumen configured to release a first portion of the secondary guidewire when an implantable medical device is advanced along the main guidewire to a first longitudinal position proximate the first portion of the guidewire and configured to release a second portion of the guidewire when the implantable medical device is advanced along the main guidewire to a second longitudinal position proximate the second portion of the guidewire.
A therapeutic device includes a tubular body including a lumen extending therethrough, a wall of the tubular body including a first composite layer, a second composite layer; and a reservoir between the first and second composite layers, the reservoir being configured to receive and contain a biological moiety. In another embodiment, a therapeutic device includes a toroidal therapeutic device having a first opening therein and a hollow interior, the toroidal therapeutic device having a wall including a first permeable composite layer, a second permeable composite layer, and a reservoir between the first and second composite layers, the reservoir being configured to receive and contain a biological moiety.
An occlusive device includes a frame element having a distal end and a proximal end, and a delivery configuration and a deployed configuration. The occlusive device also includes an occlusive face having a peripheral edge, where the occlusive face positioned toward the proximal end of the frame element. The occlusive device also includes at least one anchor positioned at the peripheral edge of the occlusive face, where the at least one anchor extends at an acute angle to the peripheral edge of the occlusive face.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
Medicament delivery devices are provided for metering delivery of a medicament over a time period to an ocular tissue. The device includes a tube, a microporous core, and a body portion with an external surface defining an internal reservoir. External surface defines a port of the body portion disposed to facilitate a first passage of the medicament from the reservoir. Tube length defines a second passage of the medicament from the first end to the second end of the tube. First end is coupled to the port to receive the first passage of the medicament from the reservoir. Second end is disposed at a distance from the first end to deliver the medicament to the ocular tissue. Microporous core is disposed in the lumen along at least a portion of the tube length and has a porosity that meters the second passage of the medicament.
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
25.
IMPLANTABLE MEDICAL DEVICE CONSTRAINT AND DEPLOYMENT APPARATUS
An implantable medical device deployment system is disclosed that employs both a sheath element and a constraint member to protect implantable medical devices during delivery in a body while providing simple, accurate, and reliable device deployment. The delivery system is configured so that loading and deployment forces are not directly related to device diameter, length, or design, thus allowing a more universal delivery system across various delivered device configurations and product lines. The deployment system can provide numerous benefits, include better protection for drug-coated implantable devices.
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
The present disclosure includes an expandable medical device and outer sheath combination. The outer sheath is capable of being split to form multiple sheath sections that may be peeled back to expose a portion or all of the expandable medical device. The medical device, as well as the outer sheath, may include one or more therapeutic agents for delivery to a treatment area within a patient.
The present disclosure is directed to pre-filled multi-dose injection devices and related therapeutic formulations and methods that lack a cloud point. The therapeutic formulation may be a transparent solution, and preservatives may remain within the aqueous phase without being phase separated to retain antimicrobial effectiveness.
Polyethylene (PE) and porous PE filaments and methods of manufacturing such filaments are disclosed for various applications, including dental floss, medical sutures, and in garments or other textile fabrics. The PE filaments may be expanded, folded, and/or otherwise manipulated to achieve desired characteristics, including porosity. The PE filaments may be light-weight, easy to grip, easy-gliding, non-shredding, and comfortable.
D01F 6/04 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyolefins
D01D 5/42 - Formation of filaments, threads, or the like by cutting films into narrow ribbons or filaments or by fibrillation of films
D01D 5/247 - Discontinuous hollow structure or microporous structure
D03D 15/283 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads synthetic polymer-based, e.g. polyamide or polyester fibres
D03D 13/00 - Woven fabrics characterised by the special disposition of the warp or weft threads, e.g. with curved weft threads, with discontinuous warp threads, with diagonal warp or weft
D03D 15/30 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the structure of the fibres or filaments
A flexible, passive pressure sensor includes three LC tank circuits. The first LC tank circuit is a pressure sensing LC tank circuit, having a capacitance that varies in response to changes in environmental pressure. The second and third LC tank circuits are reference LC tank circuits, having capacitances that are relatively constant over changes in environmental pressure. A measurement tool measures the resonant frequencies of the three LC tank circuits and then computes a pressure measurement that accounts for changes in resonant frequencies in the LC tank circuits due to environmental effects and deforming.
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01R 27/26 - Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants
A61B 5/027 - Measuring blood flow using electromagnetic means, e.g. electromagnetic flow meter using catheters
30.
STOPPERS AND METHODS OF TRANSLATING THE SAME THROUGH A TUBE
Methods and associated structures for translating a syringe stopper though a lubricant free tube, such as an insertion tube, syringe barrel or cartridge tube, during the assembly and/or use of the syringe or auto-injector. The stopper in a non-compressed state includes a proximal end, a plunger rod engaging cavity, and a sealing region having a length spaced from the proximal end by a sealing location length. The sealing region includes at least one rib having at least one microgroove within a polymer barrier, the at least one microgroove having an initial width. By the disclosed methods and structures, a translation force biased towards the outer diameter of the stopper is applied to the stopper using force concentrators. The translation force with force concentrators is sufficient to translate the stopper though the tube in a compressed state with a reduction of increase in the initial width of the at least one microgroove when compared to not using force concentrators.
A gas separation unit for the separation of carbon dioxide from air is proposed for use in a cyclic adsorption/desorption process and using a loose particulate sorbent material. The loose particulate sorbent material is disposed within an internal volume of an external support structure and supported by the external support structure, the external support structure comprising a plurality of base portions, deflected portions, and openings. The sheets are arranged parallel defining an inlet face and an outlet face, are arranged with a distance in the range of 0.1-2.5 cm (preferably 0.1-0.5 cm), and the inflow passes through the inlet face, subsequently through the particular sorbent material located in the cavity of the respective layer, subsequently to exit the layer through the outlet face to form the gas outflow. Directionality of the inflow and the outflow through the external support structure is controlled by the deflected portions of the external support structure.
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a filter for removal of waste products from a dialysate. The filter may include multiple layers of one or more filter materials configured to allow dialysate to flow through the multiple layers.
Embodiments are directed to composite membranes having a microporous polymer structure, and an ion exchange material forming a continuous ionomer phase within the composite membrane. The continuous ionomer phase refers to absence of any internal interfaces in a layer of ionomer or between any number of layers coatings of the ion exchange material provided on top of one another. The composite membrane exhibits a haze change of 0% or less after being subjected to a blister test procedure. No bubbles or blisters are formed on the composite membrane after the blister test procedure. A haze value of the composite membrane is between 5% and 95%, between 10% and 90% or between 20% and 85%. The composite membrane may have a thickness of more than 17 microns at 0% relative humidity.
H01M 8/0245 - Composites in the form of layered or coated products
H01M 8/1009 - Fuel cells with solid electrolytes with one of the reactants being liquid, solid or liquid-charged
H01M 8/1053 - Polymer electrolyte composites, mixtures or blends consisting of layers of polymers with at least one layer being ionically conductive
H01M 8/1062 - Polymeric electrolyte materials characterised by a porous support having no ion-conducting properties characterised by the physical properties of the porous support, e.g. its porosity or thickness
H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells
H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
H01M 50/489 - Separators, membranes, diaphragms or spacing elements inside the cells, characterised by their physical properties, e.g. swelling degree, hydrophilicity or shut down properties
Exemplary embodiments comprise AV fistulas and other anastomotic devices for creating new or reinforcing existing side-branch vessels, and/or bridging neighboring vessels together. An exemplary embodiment may comprise a sidewall port, such as a flanged sidewall port, and/or flow frame design, such as a partially bare, flexible stent or a whisk, for purposes of creating a transmural flow. Another exemplary embodiment may comprise a compliant vessel support to aid in the transition from device to vessel and/or vessel to device, and to promote vessel dilation.
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
A61F 2/89 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
A medical device with an expandable element and expandable tubular sleeve surrounding at least a portion of the expandable element which influences the rate, shape and/or force required to expand the expandable element and methods for use in a body lumen are provided.
An endoluminal device can comprise a flexible tubular wall and a frame member. The frame member can be comprised of a shape-memory material having sides with protrusions which are partially or substantially flattened when formed together with the flexible tubular wall to thereby create a bias in the side wall of the endoluminal device that resists deformation from a desired device profile during crush loading and is thereby resistant to invaginations when deployed.
A durable pollution control systems, articles, and methods for removing multiple flue gas pollutants. The pollution control system includes an article comprising a sorbent polymer composite (SRC), and a plurality of halogen reservoirs. In some, the halogen reservoirs are embedded within the SRC. In some, each of the halogen reservoirs has 5 wt % to 95 wt % of at least one permeation control material based on an average weight of each halogen reservoir and 5 wt % to 50% of at least one halogen source based on an average weight of each halogen reservoir.
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
38.
FORMULATIONS, METHODS, AND PRE-FILLED INJECTION DEVICES WITHOUT FATTY ACID PARTICLES
The present disclosure is directed to pre-filled injection devices and related therapeutic formulations and methods that lack fatty acid particles. The therapeutic formulation may remain fatty acid particle free or substantially fatty acid particle free over time or when subjected to accelerated aging conditions.
Mayo Foundation for Medical Education and Research (USA)
Inventor
Buchanan, Brendan S.
Espen, Benjamin I.
Houge, Reed A.
Dietz, Allan B.
Faubion, Jr., William A.
Dozois, Eric J.
Abstract
A treatment system includes an insert that is resiliently deflectable. The tip portion of the insert can be configured to be coupled to the trailing portion of an implant. A guide tube having an internal lumen is configured to permit passage of the tip portion and the body portion of the insert through a guide tube. The guide tube can have a length that is less than that of the insert. Treatment systems include a plurality of inserts, each insert differing from in at least one of length, diameter, and curvature. Treating a patient can include sizing a fistula using an insert.
A direct air capture (DAC) device and methods of controlling the same are disclosed herein. The DAC device includes a plurality of contactor elements that are aligned with respect to each other to facilitate homogenous drying and have a plurality of spacings located therebetween such that each of the contactor elements defines a contactor volume and each of the spacings defines a spacing volume. The DAC device has a total volume defined by the contactor volumes and the spacing volumes such that the DAC device is modifiable to (a) reduce the total volume for the contactor elements to facilitate desorption of one or more components of a feed stream and (b) increase the total volume for the contactor elements to facilitate adsorption of the one or more components of the feed stream.
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/06 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with moving adsorbents
A durable pollution control systems, articles, and methods for removing multiple flue gas pollutants. The pollution control system can provide a source of halogen in the required amount for a prolonged period of time. The halogen source is combined with a sorbent polymer composite substrate, configured such that the halogen does not get leached away in solutions formed during the pollution gas treatment process.
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/64 - Heavy metals or compounds thereof, e.g. mercury
42.
DELIVERY SYSTEM AID AND ASSOCIATED SYSTEMS AND METHODS
An endoluminal delivery system including an introducer sheath, a delivery catheter configured to pass through the introducer sheath, an endoluminal device releasably maintained along the delivery catheter at a delivery profile, and a guidewire tube removably received by the endoluminal device, the guidewire tube including an enlarged feature configured to prevent insertion of the guidewire tube into a body of a patient.
A device includes a plurality of elongate members, an occlusive component, and a support component. The occlusive component includes a plurality of first features each defined by a first portion of a respective elongate member. The support component includes a plurality of second features each defined by a second portion of the respective elongate member. A first termination element is defined by proximal end portions of the plurality of elongate members and located near a proximal end of the device, and a second termination element is defined by distal end portions of the plurality of elongate members and located near a distal end of the device. One or more anchor elements include a frame attachment portion and an anchor portion, the frame attachment portion including a first portion of a fixation elongate element wrapped around an elongate member, and the anchor portion including an anchor feature.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A medical device for sealing a defect in a body includes a wire frame that includes a plurality of wires that form a first occluding member and a second occluding member, the wire frame including a defect-occupying portion disposed between the first occluding member and the second occluding member. The defect-occupying portion is adapted to fill a wide range of potential defect sizes, such that no more than five devices of a range of sizes are required to effectively seal a range of nominal defect sizes of approximately 8 to 35 mm.
A device having a support structure and a covering material, the device operable to be delivered to an at least partially occluded lumen including a non-bifurcated portion, a first bifurcated portion, and a second bifurcated portion, the device comprising a body including a primary portion, a first branch, and a second branch, the primary portion defining a primary lumen, the primary portion defined between a first open end and a flow divider, the first branch defining a first branch lumen, the first branch extending from the primary portion at the flow divider to a first branch open end, and the second branch defining a second branch lumen, the second branch extending from the primary portion at the flow divider to a second branch open end, the body having a radial wall strength sufficient to resist inward radial force and collapse of the primary, first branch, and second branch lumens.
This disclosure relates to polymer electrolyte membranes, and in particular, to a composite membrane having at least two reinforcing layers comprising a microporous polymer structure and a surprisingly high resistance to piercing. This disclosure also relates to composite membrane-assemblies and electrochemical devices comprising the composite membranes of the disclosure, and to methods of manufacture of the composite membranes.
The present disclosure is directed to affinity chromatography devices including a fibrillated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3. A blend or a combination of spherical inorganic particles may be utilized. A nominal particle size of the spherical inorganic particles is from about 5 microns to about 20 microns. An affinity ligand may be bonded to the spherical inorganic particles and/or to the fibrillated polymer membrane. Also, the affinity chromatography devices have a hydraulic permeability from about 100 (×10−12 cm2) to about 500 (×10−12 cm2). Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
Some embodiments of the present disclosure relate to a composite membrane. In some embodiments, the composite membrane comprises a first fluoropolymer membrane and a second fluoropolymer membrane. In some embodiments a difference between a second surface energy of the second fluoropolymer membrane and a first surface energy of the first fluoropolymer membrane is at least 10 mN/m at 20° C. In some embodiments, the composite membrane has a Z strength of at least 5 psi.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
The present disclosure relates to improved composite electrolyte membranes with low swelling properties, membrane-electrode assemblies and electrochemical devices comprising the improved composite electrolyte membranes, and methods of manufacturing said membranes.
Various aspects of the present disclosure are directed toward medical devices, systems, and methods. The medical devices may include a portion having a radially expansive force greater than a radially expansive force other portions of the device. In addition, the medical device may include one or more constraining mechanisms for deployment of the medical devices.
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
A61M 27/00 - Drainage appliances for wounds, or the like
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include an inflow or outflow cannula apparatus. The inflow or outflow cannula apparatus may include a conduit having an exterior surface and an interior surface, an inlet portion arranged at a first end of the conduit including a plurality of elongate members arranged about a circumference of the inlet portion configured to deploy against a tissue wall, and a graft portion covering and arranged between the plurality of elongate members and extending along the interior surface of the conduit.
A61M 60/174 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps discharging the blood to the ventricle or arterial system via a cannula internal to the ventricle or arterial system
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
An expanded polytetrafluoroethylene substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure, the interlayer containing a reactive functionality, and a functional layer attached to the interlayer, the interlayer comprising a sol-gel coating or a polyvinylalcohol. The functional layer of the substrate having functional sites with a density of at least 50 nanomoles/cm2.
G01N 33/544 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
An implantable medical device for sealing and repairing defects in a body tissue or for creating an anastomosis includes a frame and a covering material. In some embodiments, the frame includes a single continuously wound wire that defines an apposition portion, a defect-occupying portion, and a sealing portion. In some embodiments, the tissue-sealing and anastomosis devices provided herein are well-suited for use in the GI tract including the small bowel and colon. In some embodiments, a two-part frame construct facilitates independent tailoring of apposition forces and radial forces exerted on tissues by the two-part frame.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
A glaucoma shunt device is provided for draining a biological fluid from an eye. The glaucoma shunt device includes a primary tube, a secondary tube, and a shunt body. The primary tube has a primary proximal end, a primary distal end, and a primary conduit extending therebetween. The secondary tube has a secondary proximal end, a secondary distal end, and a secondary conduit extending therebetween. The secondary tube is at least partially inserted through the primary conduit via the primary distal end. The secondary tube defines a flow resistance of the primary and secondary tubes. The shunt body has a reservoir therein and is integrated with the primary tube near the primary distal end such that the primary and secondary conduits are fluidly coupled with the reservoir.
A medical device frame including an undulating frame element defining a series of peaks each defining a longitudinal splay angle, circumferential cant angle, or combinations thereof. In some examples, the series of peaks are non-overlapping when the frame is in an expanded configuration and overlap when the frame is in the collapsed configuration. The longitudinal splay angle and/or circumferential cant angle may remain relatively unchanged between the expanded and collapsed configurations (e.g., within about 15%).
A61F 2/915 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/89 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
Provided herein are filter assemblies that more effectively harness the energy of a cleaning pulse. Specifically, the filter assembly may have a direction-dependent flow resistance by including a flow control component positioned downstream of the filter component and the support structure which prevents the fluid stream from a cleaning pulse from dissipating through the filter component as it cleans but allows sufficient fluid stream flowing in the forward direction through the filter component during normal operation.
The present disclosure is directed toward a semi-compliant to non-compliant, conformable balloon useful in medical applications. Conformable balloons of the present disclosure exhibit a low straightening force when in a curved configuration and at inflation pressures greater than 4 atm. Balloons of the present disclosure are constructed of material that can compress along an inner length when the balloon is in a curved configuration. In further embodiments, balloons of the present disclosure can be constructed of material that sufficiently elongates along an outer arc when the balloon is in a curved configuration. As a result, medical balloons, in accordance with the present disclosure, when inflated in a curved configuration, exhibit kink-free configurations and do not cause a significant degree of vessel straightening.
A system for endoluminal delivery of a medical device, wherein the medical device includes a bifurcated stent graft having a trunk, a first leg and a second leg shorter than the first leg. The system includes a sheath having a tubular wall having a cylindrical inner surface defining a lumen for receiving the stent graft therein to constrain the stent graft toward a delivery configuration suitable for endoluminal delivery, and a generally cylindrical core member extending through the lumen. The core member has a first annular surface for engaging an end of the first leg. The core has a second annular surface for engaging an end of the second leg while at least the end of the second leg remains constrained by the sheath.
The present disclosure describes endoluminal devices, such as stents and stent grafts capable of being bent smoothly, with various benefits resulting therefrom.
A61F 2/89 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
Some non-limiting embodiments of the present disclosure relate to a method of regenerating at least one filter medium, the method comprising flowing a flue gas stream through or by the at least one filter medium at a first temperature and increasing the temperature of the flue gas stream from the first temperature to a second temperature that exceeds the first temperature. Some non-limiting embodiments of the present disclosure relate to a method of cleaning a flue gas stream, the method comprising maintaining the NOx removal efficiency by increasing the temperature of the flue gas stream from the first temperature to a second temperature that exceeds the first temperature.
The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and a plurality of leg portions, wherein the legs are in an aligned configuration for ease of cannulation. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also described.
A catalytic membrane composite that includes porous supported catalyst particles durably enmeshed in a porous fibrillated polymer membrane is provided. The porous fibrillated polymer membrane may be manipulated to take the form of a tube, disc, or diced tape and used in multiphase reaction systems. The supported catalyst particles are composed of at least one finely divided metal catalyst dispersed on a porous support substrate. High catalytic activity is gained by the effective fine dispersion of the finely divided metal catalyst such that the metal catalyst covers the support substrate and/or is interspersed in the pores of the support substrate. In some embodiments, the catalytic membrane composite may be introduced to a stirred tank autoclave reactor system, a continuous flow reactor system, or a Parr Shaker reaction system and used to effect the catalytic reaction.
B01J 19/18 - Stationary reactors having moving elements inside
B01J 10/00 - Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles; Apparatus specially adapted therefor
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
C07C 209/36 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings
B01J 8/22 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles with liquid as a fluidising medium gas being introduced into the liquid
The present disclosure is directed toward a composite balloon comprising a layer of material having a porous microstructure (e.g., ePTFE or expanded polyethylene) and a thermoplastic polymeric layer useful for medical applications. The layers of the composite balloons become adhered through a stretch blow-molding process. Methods of making and using such composite balloons are also described amongst others.
A61L 29/14 - Materials characterised by their function or physical properties
A61L 29/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
B29C 43/18 - Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
B29C 49/22 - Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor using multilayered preforms or parisons
A61L 29/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
B29C 49/20 - Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor of articles having inserts or reinforcements
A vascular graft having a sealing layer and a tapered length portion. The sealing layer provides the vascular graft with low bleed characteristics subsequent to a needle puncture such as with a dialysis needle or a suture needle. The sealing layer in the tapered length portion has varying wall thickness along the tapered length portion.
Implantable devices may include a single, first component or a plurality of components such as first and second components, the second component being flexibly coupled to the first component. A socket extends over one or more of the component(s), the socket being configured to enhance the inter-component interaction and/or including one or more exposed surface(s) configured to exhibit one or more tiers of foreign body responses within a range of possible foreign body responses.
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61M 60/861 - Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient’s body
A61M 60/237 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
A storage bag (100) includes a main tube (102) extending from a first end to a second end and defining a first inner surface and outer surface. The main tube includes a first angled edge (128) and a second angled edge (132) extending from the first end of the main tube and forming a first angled interface. The storage bag also includes a port tube (104) extending from a first end to a second end and defining a second inner surface and outer surface. The second end of the port tube includes a third angled edge and a fourth angled edge extending from the second end of the port tube, forming a second angled interface. The second angled interface of the port tube is positioned over the first angled interface of the main tube. A portion of the port tube not overlapping the main tube is sealed to itself to form an angled drainage area (182).
An endoluminal device comprises a tubular member and a reinforcement member that is separable from, or together with, a wall of the tubular member, and removable in-situ.
Some aspects of the disclosure relate to composite materials and cultivation systems with particular utility for use in aquaculture, for example cultivating various species of seaweed. The systems comprise at least one highly tortuous and often micro-fibrous material and at least one material having low tortuosity. These systems may be configured in a variety of shapes and associated with a number of different structures. Some of these composite materials and cultivation systems may be used in both direct and indirect seeding of macroalgae plants such as seaweed.
Implantable medical devices for connecting tissue layers or occluding body conduits and tissue structures include apposition portions, a central region, and a covering material. The methods of using the devices include endoscopic deployment, and the devices may include self-expanding frameworks that facilitate a secure connection between the tissue structures. In some embodiments, one or more tethers are used to longitudinally contract the device in situ.
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
73.
MULTI-BRANCH INTRALUMINAL DEVICES AND METHODS OF MAKING AND USING SAME
An implantable device comprising a main endoprosthesis configured for implantation in a vessel, the main endoprosthesis including at least one side portal, a first side-branch endoprosthesis configured to be deployed within the main endoprosthesis and direct flow through a first side-branch vessel via the at least one side portal, a second side-branch endoprosthesis configured to be deployed within the main endoprosthesis and direct flow through a second branch vessel via the at least one side portal, and wherein when not containing a side-branch endoprosthesis the at least one side portal comprises a side channel without fluid separation.
Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site.
The present disclosure is directed to affinity chromatography devices that include a fibrillated polymer membrane that contains therein inorganic particles that separate a targeted molecule from an aqueous mixture containing the targeted molecule. The targeted molecule includes proteins, antibodies, viral vectors, nucleic acids, and combinations thereof. The inorganic particles may be spherical or irregular in shape. A blend or combination of various sizes and/or shapes of inorganic particles may be utilized. An affinity ligand may be bonded to the inorganic particles and/or to the fibrillated polymer membrane. The affinity chromatography device may be repeatedly used and may be cleaned between uses. In some embodiments, the affinity chromatography devices separate nucleic acids (e.g., mRNA) and viral vectors (e.g., adeno-associated virus) from the aqueous mixture. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
76.
AFFINITY CHROMATOGRAPHY DEVICES CONTAINING A HEAT TREATED FIBRILLATED POLYMER MEMBRANE FOR THE SEPARATION OF MRNA AND VIRAL VECTORS FROM AN AQUEOUS MIXTURE
The present disclosure is directed to affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains therein inorganic particles that separate a targeted molecule from an aqueous mixture containing the targeted molecule. The targeted molecule includes proteins, antibodies, viral vectors, nucleic acids, and combinations thereof. The inorganic particles may be spherical or irregular in shape. A blend or combination of various sizes and/or shapes of inorganic particles may be utilized. An affinity ligand may be bonded to the inorganic particles and/or to the fibrillated polymer membrane. The affinity chromatography device may be repeatedly used and may be cleaned between uses. In some embodiments, the affinity chromatography devices separate nucleic acids (e.g., mRNA) and viral vectors (e.g., adeno-associated virus) from the aqueous mixture. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
Cultivation systems including a cultivation substrate configured to promote seaweed holdfast formation and seaweed attachment are disclosed. The cultivation systems may include one or more of a nutrient phase, an adhesive, a bioactive agent, a liquid containing phase. The cultivation substrates may be patterned. The cultivation systems may specifically retain and viably maintain specific seaweed species such as dulse, kelp and nori.
A sorbent article is described including a plurality of sorbent elements structured to adsorb and desorb CO2 and a plurality of hydrophobic elements mixed with the plurality of sorbent elements and structured to exert hydrophobic force to expel liquid water from the sorbent article. Also described herein are methods of forming such sorbent articles for the purpose of swing adsorption, including for direct air capture (DAC) of carbon dioxide.
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B33Y 80/00 - Products made by additive manufacturing
79.
MULTI-ROW DEPLOY ZONE CONSTRAINING DEVICES AND METHODS
A delivery system includes a catheter with a removable constraint. The removable constraint is a knit tubular construct. The removable constraint can be used, for example, to constrain a medical device to a delivery configuration. The removable constraint may include one or more fibers or strands arranged about the device to maintain the device in a constrained or delivery configuration.
A61F 2/01 - Filters implantable into blood vessels
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
D04B 21/20 - Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
Embodiments of the present disclosure relate to transcutaneous sound sensors. In at least one embodiment, a transcutaneous sound sensor system comprises a mounting unit and a sound sensor. The mounting unit detachably connects to an electronics unit and mounts to skin on a body. The sound sensor senses sounds originating from inside the body. The sound sensor comprises an in-vivo portion and an ex-vivo portion. The in-vivo portion is configured to be inserted through and placed beneath the skin of the body. In addition, the in-vivo portion has a sound-sensing element configured to produce an electrical signal in response to a mechanical stress or strain on the sound-sensing element. The ex-vivo portion is configured to operably connect to the electronics unit when the electronics unit is connected to the mounting unit.
Drainage device for draining a biological fluid from an eye to a tissue external to the eye, as well as methods of forming the drainage device and treating glaucoma using the drainage device, are disclosed. The drainage device is implantable at least in part within a tissue of the eye and includes a collapsible body portion defining a reservoir, and a conduit having a first end fluidly coupled with the reservoir and a second end insertable into the eye to facilitate a drainage of the biological fluid into the conduit. When collapsed, the body portion includes a deformation from a first planar state to a second nonplanar state, where the second nonplanar state may be a folded, deformed, bent, or crumpled state.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
82.
A METHOD OF INSERTING A LUBRICANT FREE STOPPER INTO A LUBRICANT FREE BARREL OR A LUBRICANT FREE CARTRIDGE TUBE AND A SYSTEM FOR ASSEMBLING SAME
A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a hybrid insertion device, (2) lowering the body of the hybrid insertion device into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube while stablishing a sealable connection with the syringe barrel or cartridge tube, (3) maneuvering the stopper past the distal opening of the hybrid insertion device using an insertion pin and deploying the stopper at a final position within the syringe barrel or cartridge tube under vacuum assistance, (4) fully retracting the insertion pin from the syringe barrel or cartridge tube, and (5) retracting the hybrid insertion device from syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The hybrid insertion device may be electropolished and/or extrude honed.
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
83.
INTRODUCER SHEATH ASSEMBLY HAVING A LOCKING DILATOR
An introducer assembly includes a valve having a first end and an opposite second end; a sheath fixedly secured to and extending axially from one of the first and second ends of the valve; a dilator extending through the valve and sheath; and a lock knob rotatable between locked and unlocked positions to releasably axially lock the tool relative to the sheath without causing corresponding rotation of the tool therewith.
A multi lumen catheter assembly. The assembly provides an expandable, low profile, fixed length sheath and catheter, with fixed infusion ports. The assembly has an expandable outer sheath that expands upon pressure activation with a fluid and the sheath allows the fluid to exit from at least one predetermined fixed location from a distal end of the catheter assembly. The catheter assembly can be used in various medical device procedures, such as a TIPS (Transjugular Intrahepatic Portosystemic Shunt) procedure, or anywhere a low profile, multi lumen, infusion catheter system is desired.
A medical device may include a catheter, an expandable member, a cover, and an actuator. The catheter may include a longitudinal axis, proximal and distal ends, and a cover lumen extending from the proximal to the distal end. The expandable member may include proximal and distal ends and may be disposed on a distal section of the catheter. The cover may include a first region that may be disposed along the expandable member, and a second region that may extend along a length of the catheter beyond the proximal end of the expandable member towards the proximal end of the catheter. A first end of the cover may invert into the cover lumen. The actuator may be coupled to the first end of the cover and configured to move the first end of the cover towards the proximal end of the catheter along the longitudinal axis of the catheter.
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A retrieval catheter operable by a single clinician that will neither displace a deployed stent nor cause undue trauma to the vascular lumen or lesion. The retrieval catheter may be sized to accommodate both a guidewire and a balloon wire. The retrieval catheter is easy to navigate through tortuous passageways and will cross a previously deployed stent or stent-graft easily with minimal risk of snagging on the deployed stent or stent graft. The sheath and dilator are adapted to allow a guidewire or balloon wire to pass through the walls of both and to allow the sheath and dilator to move axially with respect to each other.
Apparatus and methods for an endovascular catheter that can be inserted within tortuous body anatomies and then selectively stiffened and fixed in place. In a particular embodiment, this stiffness is reversible. The stiffness or a comparable mechanical characteristic of the catheter assembly may be adjusted to a relatively low value during insertion (so that it easily navigates a guide wire or the like), and then subsequently adjusted to a relatively high value in situ to keep the catheter assembly substantially fixed in place (i.e., during delivery of an interventional device).
Poly(tetramethyl-p-silphenylenesiloxane) (PTMPS) membranes and porous articles made therefrom that have a matrix tensile strength in at least one direction from about 1 MPa to about 50 MPa, a matrix modulus greater than about 100 MPa in at least one direction, a porosity greater than about 30%, and a microstructure of nodes interconnected by fibrils are provided. The PTMPS polymer forming the PTMPS membranes and porous articles has a crystallinity of at least about 70%, a polydispersity from 1 to 5, and a weight average molecular weight from about 350 kDa to about 5 MDa. The PTMPS membranes may be asymmetric, meaning that the observed pore structure on one side of the PTMPS membrane is different than the pore structure on the opposing side of the PTMPS membrane. Methods of forming porous PTMPS articles are provided. Dense PTMPS articles and methods of making the same are also provided.
Some embodiments of the present disclosure relate to a device comprising a sorbent polymer composite and at least one phosphonium halide. In some embodiments, the device is configured to treat a flue gas stream. In some embodiments, the flue gas stream comprises oxygen, water vapor, at least one SOx compound, and mercury vapor. Some embodiments of the present disclosure relate to a method comprising treating the flue gas stream by: passing the flue gas stream over the device, reacting the oxygen and water vapor of the flue gas stream with the at least one SOx compound on the sorbent polymer composite, so as to form sulfuric acid, and reacting the mercury vapor with the at least one phosphonium halide, so as to fix molecules of the mercuiy vapor to the sorbent polymer composite.
Aspects of the present disclosure are directed toward apparatuses, systems, and methods for stent access and device delivery. In certain instances, the apparatuses, systems, and methods may include a plurality of struts arranged about the one or more cutting blades on a tip portion.
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
The invention comprises an indwelling medical device which is capable of delivering a therapeutic agent evenly along the length of the indwelling portion, including the outer wall, of the device.
The present disclosure includes an endoprosthesis delivery system comprising an elongate member, such as a catheter, an endoprosthesis, and an end cap having one or more protrusions extending therefrom. The protrusions may assist in retraction of end cap into an outer sheath, such as an introducer sheath. In some examples, the protrusion includes fins. In some embodiments, the endoprosthesis delivery system further includes a covering member disposed about the endoprosthesis. The protrusions may support the covering member, which may extend beyond the distal end of the endoprosthesis and onto the end cap. In some embodiments, the end cap comprises a tapered profile, which may assist in retraction of the catheter tip and end cap into an outer sheath.
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
B29C 65/02 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure
B29C 65/48 - Joining of preformed parts; Apparatus therefor using adhesives
Embodiments of the present disclosure relate to implantable cardiac sensors and associated diagnostic and treatment methods. In an exemplary embodiment, a medical system for determining a treatment regimen for a patient with a heart condition comprises a sensing device including a pressure sensor for monitoring and providing RVP information representative of right ventricle heart pressures. At least the pressure sensor is configured for implantation into a right ventricle of the patients heart. One or more processors are coupled to receive the RVP information and configured to determine a right atrial filling pressure based on the RVP information and a left atrial filling pressure based on the RVP information. A display device displays the right atrial filling pressure and the left atrial filling pressure. In embodiments, the one or more processors determine the left and right atrial filling pressures using the right ventricular pressure as a surrogate.
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
B29C 65/02 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure
B29C 65/48 - Joining of preformed parts; Apparatus therefor using adhesives
Glaucoma shunts for draining fluid from an eye to surrounding tissue and being implantable within eye tissue, the shunts include a shunt body formed from microporous materials arranged to form a reservoir within the shunt body, and a conduit having a proximal end in fluid communication with the reservoir and an opposing distal end, the distal end being insertable into the eye to facilitate drainage of fluid into the conduit via the distal end, wherein the conduit and the reservoir together define a flow passage along which drainage of fluid flows through the conduit, to the reservoir, and into surrounding tissue via the microporous material, wherein the flow passage presents a variable flow resistance along the conduit that has a plurality of sequential flow resistances with first and second flow resistances defined therein such that the first flow resistance is different from the second flow resistance.
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
97.
CONTROLLED POROSITY DEVICES FOR TISSUE TREATMENTS, METHODS OF USE, AND METHODS OF MANUFACTURE
In various embodiments, a device is provided comprising a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being the same or greater than the first pressure. In various embodiments, a method comprising fabricating a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being at or greater than the first pressure, disposing the balloon on an elongate member having a lumen, placing the lumen in fluid communication with an interior volume of the balloon.
The present disclosure includes a plurality of securing devices. For example, the present disclosure includes securing devices comprising sutures, everting anchors, and inverting anchors. The sutures and anchors disclosed herein may be capable of deployment to a depth within a body lumen, such that body tissue external to the body lumen is not damaged by the devices. Moreover, in various embodiments, the securing devices described herein may couple one or more medical devices (e.g., stents, grafts, and/or stent-grafts) to body tissue such as a body lumen.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61B 17/06 - Needles; Holders or packages for needles or suture materials
A glaucoma shunt for draining a fluid from an eye to a tissue surrounding the eye, the glaucoma shunt being implantable within tissue of the eye, the glaucoma shunt includes a shunt body that is formed from a microporous material that is arranged so as to form a reservoir within the shunt body; and a conduit in fluid communication with the reservoir, the conduit being insertable into the eye such that the fluid at a distal end of the conduit is allowed to flow through the conduit and accumulate within the reservoir, wherein the microporous material transitions from a hydrophobic state to a hydrophilic state as the fluid that is accumulated in the reservoir diffuses to the tissue surrounding the eye through the microporous material so as to provide a variable flow resistance as the microporous material transitions from the hydrophobic state to the hydrophilic state.
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A61M 27/00 - Drainage appliances for wounds, or the like
100.
VACUUM INSERTION METHODS FOR INSERTING LUBRICANT FREE SYRINGE STOPPERS AND A SYSTEM FOR ASSEMBLING SAME
Methods of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a vacuum chamber, (2) creating a seal between the vacuum chamber and a syringe barrel or a cartridge tube, (3) maneuvering the stopper into a proximal end of the syringe barrel or cartridge tube by a first differential pressure and/or an insertion rod, (4) maneuvering the stopper through the barrel by second differential pressure and/or an insertion rod, (5) optionally sealing a pressure sealing cap to the proximal end of the vacuum chamber, (6) removing the vacuum chamber, insertion rod, and, if present, the pressure sealing cap. The methods are lubricant free or substantially lubricant free. The vacuum chamber may be electropolished and/or extrude honed.
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 31/02 - Filling, closing, or filling and closing, containers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
patents
