Provided herein are filter assemblies that more effectively harness the energy of a cleaning pulse. Specifically, the filter assembly may have a direction- dependent flow resistance by including a flow control component positioned downstream of the filter component and the support structure which prevents the fluid stream from a cleaning pulse from dissipating through the filter component as it cleans but allows sufficient fluid stream flowing in the forward direction through the filter component during normal operation.
Glaucoma shunts for draining fluid from an eye to surrounding tissue and being implantable within eye tissue, the shunts include a shunt body formed from microporous materials arranged to form a reservoir within the shunt body, and a conduit having a proximal end in fluid communication with the reservoir and an opposing distal end, the distal end being insertable into the eye to facilitate drainage of fluid into the conduit via the distal end, wherein the conduit and the reservoir together define a flow passage along which drainage of fluid flows through the conduit, to the reservoir, and into surrounding tissue via the microporous material, wherein the flow passage presents a variable flow resistance along the conduit that has a plurality of sequential flow resistances with first and second flow resistances defined therein such that the first flow resistance is different from the second flow resistance.
A glaucoma shunt for draining a fluid from an eye to a tissue surrounding the eye, the glaucoma shunt being implantable within tissue of the eye, the glaucoma shunt includes a shunt body that is formed from a microporous material that is arranged so as to form a reservoir within the shunt body; and a conduit in fluid communication with the reservoir, the conduit being insertable into the eye such that the fluid at a distal end of the conduit is allowed to flow through the conduit and accumulate within the reservoir, wherein the microporous material transitions from a hydrophobic state to a hydrophilic state as the fluid that is accumulated in the reservoir diffuses to the tissue surrounding the eye through the microporous material so as to provide a variable flow resistance as the microporous material transitions from the hydrophobic state to the hydrophilic state.
A vertical farm system including a rack having a grow channel and a source of moisture/nutrients, the moisture/nutrients being deliverable to the rack. The system includes malleable material inserts in the grow channel. The malleable material inserts have an edge area, a first insert receivable within the grow channel so as to abut a second insert to form an abutting pair of edges, and a spacing component receivable between the pair of inserts, the spacing component and the abutting edge areas forming an opening extending about the spacing component, the source of moisture/nutrients communicable to the opening. In one aspect, the malleable material insert may have a slot with abutting pair of edges. A rod component is receivable between the abutting pair of edges, the rod and the abutting edges forming an opening extending about the rod component, and the source of moisture/nutrients being communicable to the opening.
Apparatus and methods which can remove, for example, mercury (Hg) from industrial flue gases. An exemplary sorbent polymer composite (SPC) can include a polymer, a sorbent which has a microstructure, and a transition metal halide in the microstructure. The transition metal halide can include silver (Ag), iodine (I), or both (AgI). A method for producing the SPC can include applying a non-halide salt of a transition metal to a sorbent, applying a non-transition metal halide to the sorbent, so as to react the non-transition metal halide with the non-halide salt of the transition metal, thereby forming a transition metal halide within the microstructure of the sorbent.
B01D 53/64 - Heavy metals or compounds thereof, e.g. mercury
B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/04 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
Methods, apparatuses, and systems for monitoring health of corneal tissue are disclosed. The system includes a corneal measurement device configured to measure a first state of health indicator that is tissue opacity or density of a region of the corneal tissue during a first period of time and a second state of health indicator that is tissue opacity or density of the region during a second period of time after the first period of time. The system further includes a processing unit configured to receive the first and second state of health indicators from the corneal measurement device and generate a health map of the region based on the first and second state of health indicators, the health map indicative of a change between the first and second state of health indicators as measured from the first period of time to the second period of time in the region of the cornea.
Endoluminal introducer sheaths and methods of forming the same are disclosed. The introducer sheath includes a first polymer layer, a second polymer layer, and at least two longitudinal support elements positioned between the first and second polymer layers. The longitudinal support elements are configured to provide columnar strength to facilitate advancement of the endoluminal introducer sheath into a vessel without substantial longitudinal compaction.
Methods, apparatuses, and systems for monitoring health of corneal tissue are disclosed. The system includes a corneal measurement device configured to measure a first state of health indicator that is tissue thickness or volume of a region of the corneal tissue during a first period of time and a second state of health indicator that is tissue thickness or volume of the region during a second period of time after the first period of time. The system further includes a processing unit configured to receive the first and second state of health indicators from the corneal measurement device and generate a health map of the region based on the first and second state of health indicators, the health map indicative of a change between the first and second state of health indicators as measured from the first period of time to the second period of time in the region of the cornea.
Dense polytetrafluoroethylene films as well as methods for preparing the present materials are provided having superior optical properties (highly transmissive, low haze, low yellowness) in combination with desirable mechanical properties (such as flexibility, strength, and durability). The highly transmissive dense films are suitable for use in a variety of optical applications, such as a cover layer for a screen in a portable electronic device.
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
Embodiments of the present disclosure relate to implantable medical devices configured to be implanted within a heart with anchor arrangements that reduce or eliminate signal transmission interference of the sensor. The implantable medical devices may include a sensor configured to sense physiological parameters of the heart and a housing comprising a transmitter and an antenna. An anchoring device formed by one or more wound wires including an engagement component is arranged around at least a portion of the housing a first frame component, a second frame component. The first frame component, the second frame component, or the first frame component and the second frame component comprise a first end separated from a second end to form a discontinuous loop and are formed from a conductive material.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a catheter-delivered implantable hemodynamic monitor (IHM) implant system with an implantable sensor.
A stopper for use in an injector device, the stopper having an outer side configured for engagement with an interior bore of an injector device barrel, includes an elastomer body and a barrier coupled to the elastomer body, the barrier having an inner surface oriented toward the elastomer body and an outer surface oriented away from the elastomer body, the barrier including a first layer of a first material and a second layer of a second material, the first layer being configured to be activatable by an energy source and the second layer configured to be less activatable by the energy source than the first layer.
Methods for manufacturing injector devices, including positioning a stopper of the injector device in a tubular member such that an outer side of the stopper is engaged with an inner surface of the tubular member and modifying the outer side of a stopper by causing relative motion between the stopper and the tubular member, the relative motion including one or both of rotational motion and vibrational motion.
A stopper for use in injector devices, where the stopper having an outer side configured for engagement with an interior bore of a barrel of the injector device. The stoppers may include an elastomer body, a multi-layer barrier coupled to the elastomer body, the multi-layer barrier having an inner surface oriented toward the elastomer body and an outer surface oriented away from the elastomer body, the multi-layer barrier including a first layer and a second layer, the first layer defining the inner surface and the second layer defining the outer surface, and the multi-layer barrier having at least one micro feature formed by the first layer, the at least one micro feature including one or both of a micro groove and/or a micro rib.
An implantable medical device includes a frame including a first structural element having a first diameter and a bias-wrapped membrane including at least a first helically wrapped film and a second helically wrapped film overlapping the first helically wrapped film at an angle, arranged on a first side of the first structural element. The first helically wrapped film has a first plurality of edges having an arcuate shape extending along the first side of the first structural element and the arcuate shape of the first plurality of fibrils extends for a majority of the first structural element side.
C08L 27/18 - Homopolymers or copolymers of tetrafluoroethene
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
Methods of reforming rib geometry of a stopper having a seal surface configured for engagement with an interior bore of a barrel of an injector device after formation of the rib include reforming a first edge of the rib.
Methods for manufacturing an injector device including a barrel having a wall defining an inner surface and a stopper that is slidably received in the barrel, the stopper having an outer side engaged with the inner surface of the wall of the barrel. The methods may include modifying a stopper by directing energy through the wall of the barrel to the stopper.
Some aspects of the disclosure relate to composite materials and cultivation systems with particular utility for use in aquaculture, for example cultivating various species of seaweed. The systems comprise at least one highly tortuous and often micro-fibrous material and at least one material having low tortuosity. These systems may be configured in a variety of shapes and associated with a number of different structures. Some of these composite materials and cultivation systems may be used in both direct and indirect seeding of macroalgae plants such as seaweed.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include an anchoring implantable medical device configured to anchor an implantable medical device.
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
20.
VIBRATORY MOTION CONVEYOR SYSTEM FOR SYRINGE PLUNGERS
A track (12) for a vibratory motion conveyor system having a length configured to support a plurality of syringe plungers (20a), each syringe plunger (20a) of the plurality of syringe plungers having a top (33), a bottom (1), and a contact feature (23) positioned between the top and bottom of the syringe plunger. The track (12) includes a first shoulder portion (16) extending along the length of the track (12) having a first support surface defining a first inner edge, and a second shoulder portion (18) extending along the length of the track having a second support surface defining a second inner edge. The first and second inner edges are arranged opposite one another such that the first and second support surfaces are configured to support the contact feature of each syringe plunger (20a) such that a portion of each syringe plunger passes between the first and second inner edges of the first and second support surfaces, respectively.
Disclosed herein are devices, systems, and methods relating to steerable catheters. A steerable catheter (100) includes a first actuation line, an inner catheter (120) and an outer catheter (110). The inner catheter has an outer surface defining a longitudinally- extending keyway. The outer catheter has an inner surface defining a lumen and a longitudinally-extending spline that that projects radially inward into the outer catheter lumen. The outer catheter lumen is operable to receive the inner catheter with the spline of the outer catheter operable to key with the keyway of the inner catheter. The spline defines a spline lumen operable to receive the first actuation line.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/128 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
An endoscopic gastric apparatus including an applier having a distal end and a proximal end. The applier further includes two gastric wall engagement elements opposing one another and in cooperative arrangement for engaging an anterior gastric wall and a posterior gastric wall into abutment and deploying a plurality of tissue fasteners, simultaneously or sequentially, and adapted for applying the tissue fasteners to fix the anterior and posterior gastric walls together for the creation of a septum within a stomach. The septum allows for fluid communication between cavities through a pathway defined by the septum adjacent the antrum.
There is provided a composite electrolyte membrane for an electrochemical device, comprising at least one reinforced polymer electrolyte membrane having a first surface and an opposing second surface. The reinforced polymer electrolyte membrane comprises a microporous polymer structure and an ion exchange material, in which the ion exchange material is at least partially embedded within the microporous polymer structure to render the microporous polymer structure occlusive. The composite electrolyte membrane further comprises a plurality of porous layers comprising a first porous layer and a second porous layer, in which the first porous layer is adjacent to the first surface of the first reinforced polymer electrolyte and the second porous layer is adjacent to the second surface of the reinforced polymer electrolyte. Also disclosed is a membrane electrode assembly comprising such a composite electrolyte membrane and a redox flow battery, fuel cell, and electrolyzer comprising such a membrane electrode assembly.
H01M 8/1053 - Polymer electrolyte composites, mixtures or blends consisting of layers of polymers with at least one layer being ionically conductive
H01M 8/106 - Polymeric electrolyte materials characterised by a porous support having no ion-conducting properties characterised by the chemical composition of the porous support
H01M 8/1062 - Polymeric electrolyte materials characterised by a porous support having no ion-conducting properties characterised by the physical properties of the porous support, e.g. its porosity or thickness
H01M 8/1067 - Polymeric electrolyte materials characterised by their physical properties, e.g. porosity, ionic conductivity or thickness
C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms two or more diaphragms
C25B 13/08 - Diaphragms; Spacing elements characterised by the material based on organic materials
This disclosure relates to electrolyzer composite membranes, and in particular, to a composite membrane having at least two reinforcing layers comprising a microporous polymer structure and a surprisingly high resistance to piercing. The electrolyzer composite membranes have a recombination catalyst configured to be disposed closer to an anode than to a cathode in a membrane-electrode assembly (MBA). The disclosure also relates to membrane-electrode assemblies and electrolyzers comprising the membranes, and to method of manufacture of the membranes.
C25B 1/04 - Hydrogen or oxygen by electrolysis of water
C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
C25B 11/093 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one noble metal or noble metal oxide and at least one non-noble metal oxide
C25B 11/097 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds comprising two or more noble metals or noble metal alloys
C25B 13/05 - Diaphragms; Spacing elements characterised by the material based on inorganic materials
C25B 13/07 - Diaphragms; Spacing elements characterised by the material based on inorganic materials based on ceramics
C25B 13/02 - Diaphragms; Spacing elements characterised by shape or form
C25B 13/08 - Diaphragms; Spacing elements characterised by the material based on organic materials
25.
HIGH TEMPERATURE INSULATIVE COMPOSITES AND ARTICLES THEREOF
High temperature insulative composites as well as articles formed from the high temperature insulative composites are described herein. The high temperature insulative composites are not only conformable, low dusting, and provide a thermal conductivity of 25 wM/m K at atmospheric conditions, but can also act as a heat propagation barrier when exposed to temperatures sufficient to partially or completely volatilize the fibrillated polymeric matrix within the high temperature insulative composite.
An implantable delivery device for dispensing a medicament that includes a first microporous material that is bonded to a second microporous material. The first microporous material has a first microporous layer including a plurality of pores sized to permit tissue ingrowth and a second microporous layer including a plurality of pores sized to permit tissue ingrowth. The second microporous material has a third microporous layer including a plurality of pores sized to resist tissue ingrowth and a fourth microporous layer including a plurality of pores sized to permit tissue ingrowth. The second microporous layer is bonded to the third microporous layer to thereby form a reservoir for receiving the medicament. The first and second microporous materials are configured to meter a rate at which the medicament is dispensed from the reservoir when the delivery device is implanted.
A sorbent article is described including a sorbent region, a desorbing media region, and a selective barrier layer positioned at least between the two regions. Also described are methods of forming the sorbent article and methods of using the sorbent article for the purpose of swing adsorption, including for direct air capture (DAC) of carbon dioxide. The selective barrier layer may be impermeable to water and water vapor to protect the sorbent region. The sorbent article may be collapsible, wherein the selective barrier layer collapses into an adsorptive configuration to maximize access to the sorbent region during adsorption and expand into a desorptive configuration to maximize access to the desorbing media region during desorption.
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01J 41/05 - Processes using organic exchangers in the strongly basic form
B01J 20/08 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising bauxite
B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/22 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A composite material is disclosed including a porous polymer substrate and a nanoporous metal present within the microporous polymer substrate. The nanoporous metal may have a hierarchical structure. The nanoporous metal may have a unimodal and right-skewed number-based nanopore size distribution. The porous polymer substrate may support tissue integration and/or tissue ingrowth in certain applications. The composite material may be used in electrochemical analyte biosensors and other applications.
Embodiments of the present disclosure relate to apparatuses, systems, and methods for percutaneous delivery of neurostimulation arrays. In an embodiment, neurostimulation lead comprises a body portion configured to transition from a collapsed delivery configuration to an expanded deployed configuration. In aspects, the expanded deployed configuration is wider than the collapsed delivery configuration. Additionally, in some embodiments, transitioning the neurostimulation lead from the collapsed delivery configuration to the expanded deployed configuration comprises unfolding or unwrapping motions that are not perpendicular to the central axis of the delivery system. In certain embodiments, the neurostimulation lead includes an array of electrodes arranged on the body portion, wherein the array of electrodes is electrically coupled to an implantable pulse generator (IPG).
An electrochemical analyte biosensor is configured to detect an analyte. The electrochemical analyte biosensor includes a biocompatible electrode composite with a microporous polymer substrate having a plurality of interconnected pores, an electrically conductive region serving as a working electrode and including a conductive material contained at least partially in the interconnected pores of the microporous polymer substrate, and at least one immobilized bioreceptor region adjacent to the electrically conductive region. The conductive material may include a conformal metal coating on the microporous polymer substrate or a nanoporous metal imbibed into the microporous polymer substrate. The microporous polymer substrate may support tissue integration and/or tissue ingrowth in certain applications. The electrochemical analyte biosensor may be used in medical, industrial, agricultural, environmental, and other applications.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
31.
AN IMPLANTABLE DEVICE FOR BRANCHED LUMENS WITH ASSOCIATED SYSTEMS AND METHODS
An implantable device comprising including a tubular member and a stent member supporting the tubular member. The tubular member includes a first end and a second end, the tubular member forming a primary lumen having a first opening at the first end of the tubular member and a second opening at the second end of the tubular member. The tubular member includes a column positioned within the primary lumen and forming a secondary lumen, the tubular member defining a plurality of apertures opening into the secondary lumen at positions longitudinally between the first end and the second end of the tubular member, the column having a column opening.
A method of deploying a multibranch stent graft at a target site having a main lumen and a first branch lumen is provided. The method includes advancing a catheter including a main body having a first portion and a second portion, the main body defining a first portal being pre-cannulated with a first guide member, partially deploying the first portion of the main body, advancing a first sheath along the first guide member through the first portal, advancing a first articulatable wire through the first sheath, positioning the first articulatable wire into a first branch lumen of the target site, partially deploying the second portion of the main body, fully deploying the first portion and the second portion of the main body, advancing a first side branch body along the first articulatable wire into the first branch lumen, and deploying the first side branch body in the first branch lumen.
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
An implantable medical device including an expandable device having a longitudinal length and operable to be compressed to a first diameter and deployed to a second diameter, wherein the second diameter is greater than the first diameter, and wherein a first portion that is less than the longitudinal length of the expandable device and a second portion that is less than the longitudinal length of the expandable device are defined on the expandable device. The medical device includes a first constraining member operable to constrain the first portion of the expandable device at the first diameter; a second constraining member operable to constrain the second portion of the expandable device at the first diameter.
A sorbent polymer composite article is disclosed for adsorption. The sorbent polymer composite article includes a composite layer comprising a porous polymer and a sorbent material. The sorbent polymer composite article also includes at least one hydrophobic layer on either side of the first composite region.
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01J 20/10 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/30 - Processes for preparing, regenerating or reactivating
A composite sorbent polymer composite article is disclosed for adsorption. The sorbent polymer composite article includes a sorbent and a flexible porous polymer, the sorbent polymer composite article having an adsorptive configuration in which the sorbent polymer composite article is configured to adsorb one or more components of a feed stream, and a desorptive configuration in which the sorbent polymer composite article is configured to remove one or more components from the sorbent polymer composite article.
B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/08 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with moving adsorbents according to the "moving bed" method
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A polymer composite article having retained solids is disclosed. The polymer composite article includes a composite region having a first porous polymer comprising a plurality of pores and the retained solids. The composite region has at least a portion of the retained solids immobilized within some of the pores. In embodiments where the retained solids are solid sorbent materials, the article is configured to receive carbon dioxide through the first porous polymer that can be adsorbed onto the solid sorbent.
Described herein are encapsulation devices that include an inner layer, an outer layer, a cell containment layer positioned between the inner and outer layer, and structural elements disposed within the cell containment layer to separate the inner and outer layers by a separation distance. The structural elements define reservoir spaces for the retention of a biological moiety (such as cells) therein. The structural elements maintain a separation distance both under external compressive forces and under internal expansive forces, such as undergoing a geometric change in the encapsulation device or during crushing and subsequent expansion of the cell encapsulation device. In some embodiments, a reinforcing layer is positioned between the inner layer and the cell containment layer. In addition, the encapsulation device may include at least one configuration element. Methods of placing encapsulation devices in a body conduit intra-luminally, extra-luminally, and via an open surgical procedure are also disclosed.
A multibranch implantable device including a main body including a tubular element having wall defining a main lumen, the tubular element having a first end defining a first opening into the main lumen and a second end defining a second opening in the main lumen, the tubular element including at least one side branch portal defining an aperture through the wall between the first longitudinal end and the second longitudinal end of the tubular element and at least one secondary body defining a secondary lumen, the at least one secondary body operable to be deployed with a portion of the secondary body positioned in the at least one side branch portal of the main body.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include an inflow or outflow cannula apparatus. The inflow or outflow cannula apparatus may include a conduit having an exterior surface and an interior surface, an inlet portion arranged at a first end of the conduit including a plurality of elongate members arranged about a circumference of the inlet portion configured to deploy against a tissue wall, and a graft portion covering and arranged between the plurality of elongate members and extending along the interior surface of the conduit.
Examples of an implantable conduit that is tubular in shape and has an inner lumen and an outer surface, the implantable conduit are disclosed. The implantable conduit includes a plurality of overlap elements including a first overlap element and a second overlap element positioned adjacent the first overlap element to define an adjacent pair of the plurality of overlap elements. The first overlap element overlaps onto the second overlap element to define an overlapping portion between an inward facing surface of the first overlap element and an outward facing surface of the second overlap element. The implantable conduit also includes a plurality of attachment features coupling the first overlap element to the second overlap element. The inward facing surface of the first overlap element and the outward facing surface of the second overlap element are separable at the overlapping portion by an external force to open an aperture in the overlapping portion between at least two of the plurality of attachment features such that the aperture defines a path between the inner lumen and outer surface of the implantable conduit. The path is sealed absent the external force.
Described embodiments are directed toward an embolic filter system. The embolic filter system generally includes an elongate element having a first end and a second end and an embolic filter assembly comprising a frame having a capture section distal to the attachment section, the capture section including a plurality of strut elements arranged to define a plurality of cells having cell ends and at least one flexion element operably coupled to and between cell ends of two adjacent cells of the plurality of cells such that the frame is operable to bend between the cell ends.
A syringe stopper containing a low level (i.e., from about 0.3 ?g to about 100 ?g) of a thin film lubricant is provided. The stopper may be positioned within a barrel of a syringe or an autoinjector. The stopper includes an elastomeric body, a solid lubricant, and a thin film lubricant. The amount of thin film lubricant present on a stopper is below a level that will induce particulation in a silicone free barrel. Additionally, the low level of thin film lubricant allows for a lower breakaway force (both wet and dry), average slide force, and a reduction in glide force compared to stoppers with no thin film lubricant. The low amount of the thin film lubricant present on the stopper also lowers the average insertion force within a syringe or vent tube compared to stoppers with no thin film lubricant, thereby allowing improved machinability inclusive of insertion.
Through observation it has been determined that deployment of delivery sleeves may result in one or more portions of the delivery sleeve extending beyond an end of the endoluminal device resulting in an overhang of material. The overhang may affect blood flow through the endoprosthesis or otherwise impact performance, including facilitating unwanted tissue growth. Various inventive concepts are provided for addressing (reducing or removing) constraining sheath overhang.
Systems and methods for increasing removal efficiency of at least one filter medium. In some embodiments, at least one oxidizing agent is introduced into the flue gas stream, so as to react SO2 with the at least one oxidizing agent to form sulfur trioxide (SO3), sulfuric acid (H2SO4), or any combination thereof. Some of the embodiments further include introducing ammonia (NH3) and/or dry sorbent into the flue gas stream, so as to react at least some of the sulfur trioxide (SO3), at least some of the sulfuric acid (H2SO4), or any combination thereof, with the ammonia (NH3) and form at least one salt.
A medical device delivery system comprises an elongate member having a main lumen configured to contain a main guidewire and at least one secondary lumen configured to releasably contain a secondary guidewire, the secondary lumen configured to release a first portion of the secondary guidewire when an implantable medical device is advanced along the main guidewire to a first longitudinal position proximate the first portion of the guidewire and configured to release a second portion of the guidewire when the implantable medical device is advanced along the main guidewire to a second longitudinal position proximate the second portion of the guidewire.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a filter for removal of waste products from a dialysate. The filter may include multiple layers of one or more filter materials configured to allow dialysate to flow through the multiple layers.
B01J 20/00 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
47.
STOPPERS AND METHODS OF TRANSLATING THE SAME THROUGH A TUBE
Methods and associated structures for translating a syringe stopper though a lubricant free tube, such as an insertion tube, syringe barrel or cartridge tube, during the assembly and/or use of the syringe or auto-injector. The stopper in a non-compressed state includes a proximal end, a plunger rod engaging cavity, and a sealing region having a length spaced from the proximal end by a sealing location length. The sealing region includes at least one rib having at least one microgroove within a polymer barrier, the at least one microgroove having an initial width. By the disclosed methods and structures, a translation force biased towards the outer diameter of the stopper is applied to the stopper using force concentrators. The translation force with force concentrators is sufficient to translate the stopper though the tube in a compressed state with a reduction of increase in the initial width of the at least one microgroove when compared to not using force concentrators.
The present disclosure is directed to pre-filled injection devices and related therapeutic formulations and methods that lack fatty acid particles. The therapeutic formulation may remain fatty acid particle free or substantially fatty acid particle free over time or when subjected to accelerated aging conditions.
Polyethylene (PE) and porous PE filaments and methods of manufacturing such filaments are disclosed for various applications, including dental floss, medical sutures, and in garments or other textile fabrics. The PE filaments may be expanded, folded, and/or otherwise manipulated to achieve desired characteristics, including porosity. The PE filaments may be light-weight, easy to grip, easy-gliding, non-shredding, and comfortable.
D01D 5/247 - Discontinuous hollow structure or microporous structure
D01D 5/42 - Formation of filaments, threads, or the like by cutting films into narrow ribbons or filaments or by fibrillation of films
D01F 6/04 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyolefins
50.
FORMULATIONS, METHODS, AND PRE-FILLED MULTI-DOSE INJECTION DEVICES WITHOUT CLOUD POINT
The present disclosure is directed to pre-filled multi-dose injection devices and related therapeutic formulations and methods that lack a cloud point. The therapeutic formulation may be a transparent solution, and preservatives may remain within the aqueous phase without being phase separated to retain antimicrobial effectiveness.
A device having a support structure and a covering material, the device operable to be delivered to an at least partially occluded lumen including a non-bifurcated portion, a first bifurcated portion, and a second bifurcated portion, the device comprising a body including a primary portion, a first branch, and a second branch, the primary portion defining a primary lumen, the primary portion defined between a first open end and a flow divider, the first branch defining a first branch lumen, the first branch extending from the primary portion at the flow divider to a first branch open end,, and the second branch defining a second branch lumen, the second branch extending from the primary portion at the flow divider to a second branch open end, the body having a radial wall strength sufficient to resist inward radial force and collapse of the primary, first branch, and second branch lumens.
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventor
Buchanan, Brendan S.
Espen, Benjamin I.
Houge, Reed A.
Dietz, Allan B.
Faubion, Jr. William A.
Dozois, Eric J.
Abstract
Embodiments of a treatment system are provided. The treatment system includes an insert that is resiliently deflectable, and a guide tube having an internal lumen. The tip portion of the insert can be configured to be coupled to the trailing portion of an implant. The guide tube is configured to permit passage of the tip portion and the body portion of the insert through a guide tube. The guide tube can have a length that is less than that of the insert, and is substantially more flexible than the insert. Treatment systems include a plurality of inserts, each insert differing from in at least one of length, diameter, and curvature. Treating a patient can include sizing a fistula using an insert.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/22 - Surgical instruments, devices or methods, e.g. tourniquets for removing obstructions in blood vessels, not otherwise provided for
53.
AFFINITY CHROMATOGRAPHY DEVICES CONTAINING A HEAT TREATED FIBRILLATED POLYMER MEMBRANE AND MANIFOLDS CONTAINING THE SAME
Affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3 are disclosed. A blend or combination of spherical inorganic particles having a nominal particle size from about 5 microns to about 20 microns may be utilized. Also, the devices have a hydraulic permeability from about 200 (X 10-12 cm2) to about 700 (X 10-12 cm2). The affinity chromatography devices have a dynamic binding capacity (DBC) greater than 35 mg/ml at 10% breakthrough at a residence time of 20 seconds. Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an operating pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices and manifolds in a parallel configuration are also disclosed.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
The present disclosure is directed to affinity chromatography devices including a fibrillated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3. A blend or a combination of spherical inorganic particles may be utilized. A nominal particle size of the spherical inorganic particles is from about 5 microns to about 20 microns. An affinity ligand may be bonded to the spherical inorganic particles and/or to the fibrillated polymer membrane. Also, the affinity chromatography devices have a hydraulic permeability from about 100 (X 10-12 cm2) to about 500 (X 10-12 cm2). Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an operating pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
Some embodiments of the present disclosure relate to a composite membrane. In some embodiments, the composite membrane comprises a first fluoropolymer membrane and a second fluoropolymer membrane. In some embodiments a difference between a second surface energy of the second fluoropolymer membrane and a first surface energy of the first fluoropolymer membrane is at least 10 mN/m at 20 °C. In some embodiments, the composite membrane has a Z strength of at least 5 psi.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
The present disclosure relates to improved composite electrolyte membranes with low swelling properties, membrane-electrode assemblies and electrochemical devices comprising the improved composite electrolyte membranes, and methods of manufacturing said membranes.
H01M 8/1053 - Polymer electrolyte composites, mixtures or blends consisting of layers of polymers with at least one layer being ionically conductive
H01M 8/106 - Polymeric electrolyte materials characterised by a porous support having no ion-conducting properties characterised by the chemical composition of the porous support
H01M 8/1062 - Polymeric electrolyte materials characterised by a porous support having no ion-conducting properties characterised by the physical properties of the porous support, e.g. its porosity or thickness
H01M 8/1067 - Polymeric electrolyte materials characterised by their physical properties, e.g. porosity, ionic conductivity or thickness
H01M 8/1069 - Polymeric electrolyte materials characterised by the manufacturing processes
H01M 8/1081 - Polymeric electrolyte materials characterised by the manufacturing processes starting from solutions, dispersions or slurries exclusively of polymers
This disclosure relates to polymer electrolyte membranes, and in particular, to a composite membrane having at least two reinforcing layers comprising a microporous polymer structure and a surprisingly high resistance to piercing. This disclosure also relates to composite membrane-assemblies and electrochemical devices comprising the composite membranes of the disclosure, and to methods of manufacture of the composite membranes.
H01M 8/1053 - Polymer electrolyte composites, mixtures or blends consisting of layers of polymers with at least one layer being ionically conductive
H01M 8/106 - Polymeric electrolyte materials characterised by a porous support having no ion-conducting properties characterised by the chemical composition of the porous support
H01M 8/1067 - Polymeric electrolyte materials characterised by their physical properties, e.g. porosity, ionic conductivity or thickness
C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
C25B 13/08 - Diaphragms; Spacing elements characterised by the material based on organic materials
H01M 8/1081 - Polymeric electrolyte materials characterised by the manufacturing processes starting from solutions, dispersions or slurries exclusively of polymers
Some non-limiting embodiments of the present disclosure relate to a method of regenerating at least one filter medium, the method comprising flowing a flue gas stream through or by the at least one filter medium at a first temperature and increasing the temperature of the flue gas stream from the first temperature to a second temperature that exceeds the first temperature. Some non-limiting embodiments of the present disclosure relate to a method of cleaning a flue gas stream, the method comprising maintaining the NOx removal efficiency by increasing the temperature of the flue gas stream from the first temperature to a second temperature that exceeds the first temperature.
B01D 29/00 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ; Filtering elements therefor
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
Cultivation systems including a cultivation substrate configured to promote seaweed holdfast formation and seaweed attachment are disclosed. The cultivation systems may include one or more of a nutrient phase, an adhesive, a bioactive agent, a liquid containing phase. The cultivation substrates may be patterned. The cultivation systems may specifically retain and viably maintain specific seaweed species such as dulse, kelp and nori.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
B01D 71/00 - Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
A delivery system includes a catheter with a removable constraint. The removable constraint is a knit tubular construct. The removable constraint can be used, for example, to constrain a medical device to a delivery configuration. The removable constraint may include one or more fibers or strands arranged about the device to maintain the device in a constrained or delivery configuration.
A61F 2/97 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
D04B 21/20 - Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
61.
MULTI-BRANCH INTRALUMINAL DEVICES AND METHODS OF MAKING AND USING SAME
An implantable device comprising a main endoprosthesis configured for implantation in a vessel, the main endoprosthesis including at least one side portal, a first side-branch endoprosthesis configured to be deployed within the main endoprosthesis and direct flow through a first side-branch vessel via the at least one side portal, a second side-branch endoprosthesis configured to be deployed within the main endoprosthesis and direct flow through a second branch vessel via the at least one side portal, and wherein when not containing a side-branch endoprosthesis the at least one side portal comprises a side channel without fluid separation.
A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a hybrid insertion device, (2) lowering the body of the hybrid insertion device into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube while stablishing a sealable connection with the syringe barrel or cartridge tube, (3) maneuvering the stopper past the distal opening of the hybrid insertion device using an insertion pin and deploying the stopper at a final position within the syringe barrel or cartridge tube under vacuum assistance, (4) fully retracting the insertion pin from the syringe barrel or cartridge tube, and (5) retracting the hybrid insertion device from syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The hybrid insertion device may be electropolished and/or extrude honed.
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 7/16 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
Embodiments of the present disclosure relate to transcutaneous sound sensors. In at least one embodiment, a transcutaneous sound sensor system comprises a mounting unit and a sound sensor. The mounting unit detachably connects to an electronics unit and mounts to skin on a body. The sound sensor senses sounds originating from inside the body. The sound sensor comprises an in-vivo portion and an ex-vivo portion. The in-vivo portion is configured to be inserted through and placed beneath the skin of the body. In addition, the in-vivo portion has a sound-sensing element configured to produce an electrical signal in response to a mechanical stress or strain on the sound-sensing element. The ex-vivo portion is configured to operably connect to the electronics unit when the electronics unit is connected to the mounting unit.
Delivery systems (100) are described that include endoprostheses (102) configured to transition from compact, delivery configurations to enlarged, deployed configurations, delivery catheters including body (108) and tip (112) portions, the endoprostheses being received on body portions in the compact, delivery configuration, the tip portions including lips (114) configured to define pockets (114A) that releasably receive the endoprosthesis in the compact, delivery configuration, and constraints releasably maintaining the endoprostheses in the compact, delivery configuration. Additional and alternative delivery system features and associated methods are provided.
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
65.
ARTICLES CONTAINING EXPANDED POLY (TETRAMETHYL-P-SILPHENYLENESILOXANE) AND METHODS FOR PRODUCING THE SAME
Poly(tetramethyl-p-silphenylenesiloxane) (PTMPS) membranes and porous articles made therefrom that have a matrix tensile strength in at least one direction from about 1 MPa to about 50 MPa, a matrix modulus greater than about 100 MPa in at least one direction, a porosity greater than about 30%, and a microstructure of nodes interconnected by fibrils are provided. The PTMPS polymer forming the PTMPS membranes and porous articles has a crystallinity of at least about 70%, a polydispersity from 1 to 5, and a weight average molecular weight from about 350 kDa to about 5 MDa. The PTMPS membranes may be asymmetric, meaning that the observed pore structure on one side of the PTMPS membrane is different than the pore structure on the opposing side of the PTMPS membrane. Methods of forming porous PTMPS articles are provided. Dense PTMPS articles and methods of making the same are also provided.
C08J 9/232 - Forming foamed products by sintering expandable particles
C08L 83/14 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Compositions of derivatives of such polymers in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
C08G 77/52 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages containing aromatic rings
66.
VACUUM INSERTION METHODS FOR INSERTING LUBRICANT FREE SYRINGE STOPPERS AND A SYSTEM FOR ASSEMBLING SAME
Methods of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of vacuum chamber, (2) creating a seal between the vacuum chamber and a syringe barrel or a cartridge tube, (3) maneuvering the stopper into a proximal end of the syringe barrel or cartridge tube by a first differential pressure and/or an insertion rod, (4) maneuvering the stopper through the barrel by second differential pressure and/or an insertion rod, (5) optionally sealing a pressure sealing cap to the proximal end of the vaccum chamber, (6) removing the vacuum chamber, insertion rod, and, if present, the pressure sealing cap. The methods are lubricant free or substantially lubricant free. The vacuum chamber may be electropolished and/or extrude honed.
A61M 5/315 - Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
B65B 31/02 - Filling, closing, or filling and closing, containers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
Embodiments of the present disclosure relate to implantable cardiac sensors and associated diagnostic and treatment methods. In an exemplary embodiment, a medical system for determining a treatment regimen for a patient with a heart condition comprises a sensing device including a pressure sensor for monitoring and providing RVP information representative of right ventricle heart pressures. At least the pressure sensor is configured for implantation into a right ventricle of the patient's heart. One or more processors are coupled to receive the RVP information and configured to determine a right atrial filling pressure based on the RVP information and a left atrial filling pressure based on the RVP information. A display device displays the right atrial filling pressure and the left atrial filling pressure. In embodiments, the one or more processors determine the left and right atrial filling pressures using the right ventricular pressure as a surrogate.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/029 - Measuring blood output from the heart, e.g. minute volume
68.
MULTI-DEPLOY ZONE CONSTRAINING DEVICES AND METHODS
A removable constraining device, systems, and methods for constraining and delivering an expandable member is disclosed. The removable constraining device includes a plurality of strands interlocking to form a cover body having a length, the plurality of strands in the form of a warp knit, and the plurality of strands including at least a first set of strands and a second set of strands. The removable constraining device also includes a first release zone defined by the first set of strands of the cover body along the length of the cover body and a second release zone defined by the seconds set of strands of the cover body, the second release zone being coextensive with the first release zone along at least a portion of the length of the cover body. The removable constraining device may be released at release zones by substantially simultaneously tensioning deployment lines.
Bifurcated endoprosthetic devices, systems and methods are disclosed herein for treating disease of human vasculature. In various embodiments, a bifurcated endoprosthesis includes a trunk portion and a plurality of legs, where the legs are constrained such that they maintain alignment with one another. In some examples, the legs and bifurcation of an endoprosthetic device may be formed by cutting a tubular graft component along a portion of less than its entire circumference in a longitudinally central region, and then folding the tubular graft component along the uncut portion to define two legs, where the uncut portion defines the bifurcation. In some such examples, the folded tubular graft component can be coupled with a tubular trunk component to form the bifurcated endoprosthetic device.
An endoprosthesis having a length, a first end, a second end, and a longitudinal axis is disclosed herein, where the endoprosthesis is expandable from a compact, delivery configuration to an enlarged, deployed configuration. The endoprosthesis includes a plurality of rows of stent elements along the length of the endoprosthesis, where the plurality of rows include a first row and a second row located adjacent to the first row. The first row of stent elements has a first plurality of alternating apices, and the second row of stent elements has a second plurality of alternating apices. The first and second pluralities of alternating apices define a spaced apart, interlocking arrangement. The endoprosthesis also includes a discontinuous web of material comprising a plurality of web elements spaced from one another and interconnecting the first and second pluralities of alternating apices. The plurality of web elements are arranged along a first, common circumference such that the plurality of web elements restrict torsion and axial compression of the endoprosthesis between the first and second rows of stent elements when the endoprosthesis is in the enlarged, deployed configuration.
A61F 2/89 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/915 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
71.
SUSTAINED-RELEASE MATRICES FOR ADVENTITIAL OR PERIADVENTITIAL NEURAL ABLATION AND USES THEREOF
A denervation formulation including a denervation drug incorporated into a sustained-release matrix. The sustained-release matrix may include a polycarbonate and a fluoropolymer. The sustained-release matrix may form a plurality of particles to encapsulate the denervation drug. The denervation formulation may be delivered to a patient's autonomic neural tissue, including but not limited to a renal sympathetic nerve, a carotid nerve, a pulmonary nerve, and/or a cardiac sympathetic nerve. Upon release, the denervation drug may ablate the patient's autonomic neural tissue for treatment of cardiac disease, including but not limited to hypertension, heart failure, and/ or atrial and ventricular tachycardia.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61P 25/00 - Drugs for disorders of the nervous system
72.
COMPOSITE MEMBRANE WITH NANOSELECTIVE SURFACE FOR ORGANIC SOLVENT NANOFILTRATION
Organic solvent nanofiltration membranes that include at least one polymer coated expanded polyparaxylylene (ePPX) membrane are provided. A substrate/support layer may be positioned on one side of the ePPX membrane. In some embodiments, the substrate/support layer is sandwiched between ePPX membranes. Processes for manufacturing and using such organic solvent nanofiltration membranes are also provided. The organic solvent nanofiltration membranes are capable of separating and/or concentrating solutes from a solution comprising a lower molecular weight organic solvent with high permeability. The polymer coated ePPX membranes may also be resistant to chemical attack, resistant to gamma radiation, thermally stable, biocompatible, and strong.
An implantable medical device comprising a first frame component. The first frame component including a first set of elongate elements configured to conform to an anatomy of a patient. The implantable medical device also comprising a second frame component including a second set of elongate elements configured to conform to an anatomy of a patient. The first frame component and the second frame component being discrete and separate from one another. The implantable medical device also comprising a conduit portion arranged between the first frame component and the second frame component. The conduit portion including a membrane connecting the first frame component and the second frame component.
A61F 2/89 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
An implantable medical device comprising a first frame component. The first frame component including a first set of elongate elements configured to conform to an anatomy of a patient. The implantable medical device also comprising a second frame component including a second set of elongate elements configured to conform to an anatomy of a patient. The first frame component and the second frame component being discrete and separate from one another. The implantable medical device also comprising a conduit portion arranged between the first frame component and the second frame component. The conduit portion including a membrane connecting the first frame component and the second frame component.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
According to an example of the present disclosure, an apparatus to store slack in a system line for a medical device is disclosed. The apparatus comprises a plurality of slack pockets arranged in series. The system line is configured to form a slack loop into each slack pocket, the plurality of slack pockets isolating the slack loops from each other. The plurality of slack pockets are configured such that when tension is applied to the system line, slack is dispensed by each slack loop straightening from each slack pocket without tangling with another one of the slack loops.
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
76.
SUPPORT STRUCTURE FOR AN IMPLANTABLE DEVICE WITH ENHANCED COMPRESSIVE STIFFNESS REGION(S)
Various examples address support structures (e.g., prosthetic valve support structures or frames) that incorporate a frame that, upon transitioning to a deployed configuration, include a proximal section has increased stiffness, or resistance to deformation in a transverse plane to a longitudinal axis of a device, including resistance to a change in shape, size, or both. Such an increase in transverse deformation resistance may be measured as an increase in radial compressive resistance or an increase in flat plate stiffness, for example, or both. Such increases in transverse deformation resistance may be realized through a reduction in length of the increased stiffness region of the support structure, such as through longitudinal compression of the region following an initial radial expansion of the region.
A61F 2/915 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Various aspects of the present disclosure are directed toward devices, methods, and systems that include a reinforced biopolymer including a synthetic support membrane and a biopolymer. The reinforced biopolymer may have a measured optical transparency of at least 85%, a thickness of about 100 µm or less, and a toughness of at least 30 KJ/m3.
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
78.
POROUS POLYTETRAFLUOROETHYLENE MEMBRANE HAVING A MACRO-TEXTURED SURFACE AND METHOD FOR MAKING THE SAME
Compositions and methods directed to the production of single layer, highly porous, free-standing polytetrafluoroethylene (PTFE) membranes having macro- textured surfaces are provided. The macro-textured surfaces are due to the presence of macroscopic nodal aggregates within the membrane that are connected by fibrils The membranes have high porosity, high airflow, and a bulk density less than 1.0 g/cm3. Articles comprising the porous, single layer PTFE membranes are also provided.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 46/54 - Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
Some embodiments of the present disclosure relate to a device comprising: a capacitor and at least one encapsulant. In some embodiments, the at least one encapsulant comprises at least one polymer. In some embodiments, the at least one encapsulant at least partially encapsulates the capacitor. In some embodiments, the at least one encapsulant has a stable Young's modulus. Some embodiments of the present disclosure further relate to methods of manufacturing and using the device described herein. In the examples the at least one polymer is a PVDF.
The present disclosure is directed toward drug coated balloons, and in particular to drug coated balloons having a drug coating layer that primarily uses therapeutic agents alone for improving the quality of treatments in which drug coated balloons are utilized. Particular aspects may be directed to drug coated balloon having an outer surface, and a drug coating layer on the outer surface of the balloon. The drug coating layer includes at least one therapeutic agent and is substantially free of excipients.
A device for placement in vessels, appendages, and openings in a body, the device comprising: a frame having a plurality of elongate members, the frame including: a substantially uniform proximal end of the frame having (i) a center frame portion arranged at the proximal end and (ii) face portions of the plurality of elongate members extending from the center frame portion and including a curved pattern arranged substantially within a first plane approximately perpendicular to a longitudinal axis of the frame; a body portion; a membrane coupled to at least the substantially uniform proximal end of the frame; and a coating arranged on at least a portion of the membrane configured to minimize the thrombogenic response of blood contact with the membrane.
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
82.
LIQUID COMPOSITION AND POROUS HARDENED MATERIAL COMPRISING TETRAFLUOROETHYLENE AND VINYL MOIETY CO-POLYMERS
A porous hardened material is provided for various medical applications, including strengthening, supporting, moving, reinforcing, separating, isolating, and/or bulking biological substrates. The hardened material is formed from a liquid composition including a fluorinated copolymer and a biocompatible solvent system. The fluorinated copolymer includes a tetrafluoroethylene (TFE) moiety and a vinyl moiety, wherein the vinyl moiety comprises at least one functional group selected from acetate, alcohol, amine, and amide.
Some embodiments of the present disclosure relate to a method of regenerating at least one filter medium comprising: providing at least one filter medium, wherein the at least one filter medium comprises: at least one catalyst material; and ammonium bisulfate (ABS) deposits, ammonium sulfate (AS) deposits, or any combination thereof; flowing a flue gas stream transverse to a cross- section of a filter medium, such that the flue gas stream passes through the cross section of the at least one filter medium, wherein the flue gas stream comprises: NOx compounds comprising: Nitric Oxide (NO), and Nitrogen Dioxide (NO2); and increasing an NOx removal efficiency of the at least one filter medium after removal of deposits.
A therapeutic device includes a pouch having opposed first and second ends and first and second composite layers extending between the opposed first and second ends. The first composite layer includes a first cell permeable layer extending between the opposed first and second ends and a first cell retentive layer extending between the opposed first and second ends. The pouch includes a reservoir formed between the first and second composite layers, contacting the first cell retentive layer, and at least one port in fluid communication with the reservoir. The therapeutic device further includes a removal element configured to operably engage the first end of the pouch, to cause the first end to be moveable towards the second end by eversion. In some embodiments, each of the first and second composite layers includes a plurality of wrinkles that are incrementally disengaged from a tissue to remove the therapeutic device atraumatically.
A therapeutic device includes a tubular body including a lumen extending therethrough, a wall of the tubular body including a first composite layer, a second composite layer; and a reservoir between the first and second composite layers, the reservoir being configured to receive and contain a biological moiety. In another embodiment, a therapeutic device includes a toroidal therapeutic device having a first opening therein and a hollow interior, the toroidal therapeutic device having a wall including a first permeable composite layer, a second permeable composite layer, and a reservoir between the first and second composite layers, the reservoir being configured to receive and contain a biological moiety.
Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include tissue anchors such as for chordae tendineae repair.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A nickel-titanium alloy with an average grain size of between 0.2 and 10 microns and a recoverable strain of greater than 9% is disclosed herein, in which the alloy is formed using a rnethod which involves applying a shape set heat treatment to the nickel-titanium alloy. The heat treatment includes applying heat at a temperature between 225 C and 350 C for a period of time between 20 and 240 minutes.
C22C 19/03 - Alloys based on nickel or cobalt based on nickel
C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
C22F 1/18 - High-melting or refractory metals or alloys based thereon
88.
WIRES OF NICKEL-TITANIUM ALLOY AND METHODS OF FORMING THE SAME
A wire of a nickel-titanium alloy having a permanent set of less than 5% when 11% strain is applied to the wire is disclosed. The wire may be formed by applying a first heat treatment to the wire, the first heat treatment includes applying heat of a first temperature for a first period of time, applying a strain deformation to the wire to set a shape for the wire during the first heat treatment, and applying a second heat treatment to the wire. The second heat treatment includes applying heat of a second temperature different from the first temperature for a second period of time, and the second temperature is between 210 °C and 290 °C. The wire may have a modulus of at least 53 GPa when 200 MPa of stress is applied to the wire, and the wire is bonded to a secondary component.
C22C 19/03 - Alloys based on nickel or cobalt based on nickel
C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
C22F 1/18 - High-melting or refractory metals or alloys based thereon
89.
WIRES OF SUPERELASTIC NICKEL-TITANIUM ALLOY AND METHODS OF FORMING THE SAME
A wire comprising a nickel-titanium alloy having a recoverable strain of greater than 9% in length is disclosed herein. The wire undergoes a residual elongation of less than 0.5% in response to applying the recoverable strain.
C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
C22F 1/18 - High-melting or refractory metals or alloys based thereon
Described embodiments are directed to a device for delivery of activatable compounds to a patient's lumen, such as in transcatheter procedures. More specifically, described embodiments are directed toward delivery devices operable to deliver the activatable compounds and to activate the compounds by light. Such delivery devices include a balloon (14) having a treatment zone (16) for activatable compound delivery and/or activation and non-treatment zones (18) that block activatable compound delivery and/or activation for controlled delivery and activation of the activatable compounds.
Biointerfaces configured to retain and viably maintain non-mammalian cells are disclosed. The biointerfaces may include one or more of a nutrient phase, an adhesive, a bioactive agent, a liquid containing phase. The biointerfaces may be patterned. The biointerfaces may specifically retain and viably retain specific non mammalian cell types such as spores of seaweed. The biointerfaces are used for growing seaweed such as dulse and kelp.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
B01D 71/00 - Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
A culture string for cultivation of algae is disclosed. The culture string comprises fibrillated strands of expanded polymer, expanded fluoropolymer, or expanded thermoplastic polymer and having a microstructure to allow algae growth into the fibrillated material in all three dimensions. The fibrillated strands may be interwoven.
Cultivation systems including a cultivation substrate configured to retain and viably maintain spores and germinated spores are disclosed. The cultivation systems may include one or more of a nutrient phase, an adhesive, a bioactive agent, a liquid containing phase. The cultivation substrates may be patterned. The cultivation systems may specifically retain and viably retain specific spore types.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/00 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
B01D 71/00 - Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
The invention relates to tissue anchor in medical procedures. More specifically the invention relates to a tethered anchor. Tethered anchor including a tether portion and an anchor portion that are continuously braided with one another, the tether portion extending continuously from the anchor portion; and the anchor portion having a greater width than a width of the tether portion.
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/06 - Needles; Holders or packages for needles or suture materials
A dental floss cartridge is disclosed. The cartridge includes a housing, a roll of dental floss comprising a polymer such that the dental floss has a first surface and a second surface, a floss exit opening in the housing through which the floss is configured to exit, a texture-inducing structure arranged within the housing and configured to impart texture onto at least one of the first and second surfaces of the dental floss prior to or during the dental floss passing through the floss exit opening, and a cutting device on an exterior of the housing configured to cut the dental floss into a desired length.
A dental floss cartridge is disclosed. The cartridge includes a housing, a roll of dental floss comprising a polymer and attached within the housing, a floss exit opening in the housing, and a cutting device on an exterior of the housing configured to cut the dental floss into a desired length. The dental floss is configured to dispense from the roll and create a twist in the dental floss.
Thin, self-supporting biaxially expanded polytetrafluoroethylene (ePTFE) membranes that have a high crystallinity index, high intrinsic strength, low areal density (i.e., lightweight), and high optical transparency are provided. In particular, the ePTFE membrane may have a crystallinity index of at least about 94% and a matrix tensile strength at least about 600 MPa in both longitudinal and transverse directions. In addition, the ePTFE membrane is transparent or invisible to the naked eye through a complete conversion of the PTFE primary particles into fibrils. The ePTFE membrane may have a thickness per layer of less than 100 nm and a porosity greater than 50%. Further, the ePTFE membrane is stackable, which, in turn, may be used to control permeability, pore size, and/or bulk mechanical properties. The ePTFE membrane may be used to form composites, laminates, fibers, tapes, sheets, tubes, or three-dimensional objects. Additionally, the ePTFE membrane may be used in filtration applications.
Self-supporting uniaxially expanded polytetrafluoroethylene (ePTFE) membranes that have high intrinsic strength, a high matrix modulus, and a high crystallinity index are provided. In some embodiments, the ePTFE membrane is stretched in the machine direction. Uniaxially oriented ePTFE membranes have a matrix tensile strength at least about 1000 MPa in the machine direction, a matrix modulus at least about 100 GPa ambient temperature (i. e., about 20°C), and a crystallinity index of at least about 94%. In some embodiments, the ePTFE membrane has a tenacity greater than or equal to about 5 gf/d and a denier less than or equal to about 750 g/9000 m. In addition, the uniaxially oriented ePTFE membranes have a orientation of at least about 0.98. Also, the fibrils in the ePTFE membranes have a nearly perfect parallel alignment. The ePTFE membrane may be used to form composites, laminates, fibers, tapes, sheets, tubes, or other three-dimensional objects.
There is provided a method of wetting a low surface energy substrate with a high surface tension liquid cornprising at least the steps of providing a low surface energy substrate having a surface energy in the range of frorn 15 to 45 mN/rn, a high surface tension liquid having a surface tension in the range of from greater than 25 to 70 rnN/rn and a low surFace tension fluid having a surface tension in the range of from 10 to 25 rnN/rn; contacting the low surface energy substrate with the high surface tension liquid; contacting at least one of the low surface energy substrate and the high surface tension liquid with the low surface tension fluid vapour, either before, at the sarne time as or after the contacting of the low surface energy substrate with the high surface tension liquid; and removing the low surface tension fluid vapour from the low surface energy substrate. The high surface tension liquid can be used as a carrier liquid for a coating material, such as an ion exchange material, to be deposited on the substrate, such as ePTFE, in a method of coating. Also disclosed is a system for such coating methods.
B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
H01M 8/1023 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
H01M 8/1086 - After-treatment of the membrane other than by polymerisation
100.
METHOD OF WETTING LOW SURFACE ENERGY SUBSTRATE AND A SYSTEM THEREFOR
Provided is a method of determining the improvement in the wetting of a low surface energy substrate with a high surface tension liquid. The method includes measuring a contact angle between (i) the low surface energy substrate and high surface tension liquid interface and (ii) the high surface tension liquid and the vapour interface and measuring a contact angle between (iii) the low surface energy substrate and high surface tension liquid interface and (iv) the high surface tension liquid and the vapour (atmosphere) interface upon contacting with the low surface tension fluid as a vapour. The improvement in the wetting is determined as the reduction in contact angle between (i) and (ii) and the contact angle between (iii) and (iv).
B05D 5/04 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a surface receptive to ink or other liquid
H01M 8/1086 - After-treatment of the membrane other than by polymerisation
C08J 7/02 - Chemical treatment or coating of shaped articles made of macromolecular substances with solvents, e.g. swelling agents
patents
