The Regents of the University of California

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C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 966
A61K 38/00 - Medicinal preparations containing peptides 470
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons 469
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1.

METHODS FOR TREATING ALCOHOLIC LIVER DISEASE, ALCOHOL-INDUCED BRAIN INJURY AND REDUCING ALCOHOL ADDICTION

      
Application Number 16639514
Status Pending
Filing Date 2018-08-31
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Kisseleva, Tatiana
  • Brenner, David
  • Xu, Jun

Abstract

In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for reducing addiction to alcohol, and for ameliorating, reversing, treating or preventing Alcoholic Liver Disease (ALD), or alcohol-induced brain injury, wherein optionally the alcohol-induced brain injury comprises neuronal death and astrogliosis (reducing alcohol-induced neuronal death and astrogliosis). In alternative embodiments, provided methods for administering to the individual in need thereof a compound or composition capable of inhibiting or decreasing the expression or activity of an IL-17 or IL-17 receptor (IL-17R) or RORγt protein, transcript and/or gene to treat or for use in: reducing addiction to alcohol; or ameliorating, reversing, treating or preventing Alcoholic Liver Disease (ALD) or alcohol-induced brain injury; or, inhibiting ROR γt to effectively block production of IL-17 cytokines and attenuate development of alcohol-induced liver fibrosis and brain damage.

IPC Classes  ?

  • C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
  • A61P 25/32 - Alcohol-abuse
  • A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

2.

LITHIUM-EXCESS TRANSITION-METAL-DEFICIENT SPINELS FOR FAST CHARGING/DISCHARGING LITHIUM-ION BATTERY MATERIALS

      
Application Number 16928743
Status Pending
Filing Date 2020-07-14
First Publication Date 2021-01-21
Owner The Regents of University of California (USA)
Inventor
  • Ceder, Gerbrand
  • Ji, Huiwen

Abstract

Li-ion battery materials, such as Li-ion cathodes, are provided that have spinels characterized by a close-packed face-centered-cubic rocksalt-type structure and spinel-like ordered TM (the TM preferably occupying one of the two octahedral sites 16c and 16d) that favor fast Li transport kinetics. Such spinels have a larger deviation from a normal spinel and have a formula. Li1+xTM2-yO4-zFz where 0.2≤x≤1, 0.2≤y≤0.6, and 0≤z≤0.8; and TM is Mn, Ni, Co, Al, Sc, Ti, Zr, Mg, Nb, or a mixture thereof. The spinels achieve a higher gravimetric energy density than traditional spinels while still retaining high capacity at an extremely fast charging/discharging rate.

IPC Classes  ?

  • H01M 4/134 - Electrodes based on metals, Si or alloys
  • H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
  • H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
  • H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
  • H01M 4/36 - Selection of substances as active materials, active masses, active liquids
  • H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
  • H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
  • C01G 45/12 - Manganates; Permanganates

3.

NONRECIPROCAL AND RECONFIGURABLE PHASED-ARRAY ANTENNAS

      
Application Number 16931281
Status Pending
Filing Date 2020-07-16
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Gómez-Diaz, Juan Sebastián
  • Álvarez-Melcón, Alejandro
  • Zang, Jiawei

Abstract

A nonreciprocal phased-array antenna includes an array of resonant antennas a1, . . . , an. During transmission, an outbound signal having a frequency f0 and a phase shift φdi caused by propagation through a data network feeds into each resonant antenna ai. Each resonant antenna a, upconverts the outbound signal using a modulation signal having a frequency fm and a phase shift φmi caused by propagation through a modulation network to produce an upconverted radiated signal having a frequency f0+fm and a phase proportionate to φdi+φmi. During reception, an inbound signal of frequency f0+fm is received at each resonant antenna ai and is downconverted using the modulation signal to produce a downconverted signal having a frequency f0 and a phase proportionate to −φmi. After passing through the data network to the inbound port, the downconverted signal has a phase proportionate to φdi−φmi.

IPC Classes  ?

  • H01Q 3/36 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with variable phase-shifters
  • H01Q 21/29 - Combinations of different interacting antenna units for giving a desired directional characteristic

4.

ENGINEERED B LYMPHOCYTES AND COMPOSITIONS HAVING MICRO-RNA AND METHODS FOR MAKING AND USING THEM

      
Application Number 16866055
Status Pending
Filing Date 2020-05-04
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor Zanetti, Maurizio

Abstract

Provided are engineered B lymphocytes modified to express one or several different types of microRNAs or anti-miRs where in one embodiments the lymphocytes contain multiple copy numbers of nucleic acids encoding the one or several different types of miRs or anti-miRs. Provided are compositions and methods for treating, ameliorating, or preventing a cancer cell, a breast cancer cell or a triple negative breast cancer, or a breast cancer cell that tests negative for estrogen receptors, progesterone receptors, or HER2, comprising or by administering a composition, formulation or pharmaceutical composition comprising a microRNA or anti-miR. Provided are methods for treating an inflammation, a disease, a condition, infection or cancer capable of being treated by modulation or inhibition or expression of an miRNA or anti-miRs by administering to an individual in need thereof a B lymphocyte that secretes a microRNA or anti-miR, or a B lymphocyte supernatant, extracellular vesicle or exosome having a microRNA or anti-miR.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • A61K 9/127 - Liposomes
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • A61P 35/00 - Antineoplastic agents
  • C12N 5/0781 - B cells; Progenitors thereof
  • A61K 9/51 - Nanocapsules
  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

5.

RAPID AND PRECISE TOOL EXCHANGE MECHANISM FOR INTRAOCULAR ROBOTIC SURGICAL SYSTEMS

      
Application Number 16982506
Status Pending
Filing Date 2019-03-20
First Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Tsao, Tsu-Chin
  • Gerber, Matthew

Abstract

A system for intraocular robotic surgery includes: (1) a set of mounts to receive a tool collar to which a surgical tool is secured; (2) a rotational actuator connected to the set of mounts to drive rotation of the set of mounts; and (3) a translational actuator connected to the set of mounts to drive linear translation of the set of mounts.

IPC Classes  ?

  • A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
  • A61B 34/35 - Surgical robots for telesurgery
  • A61B 34/37 - Master-slave robots
  • B25J 5/00 - Manipulators mounted on wheels or on carriages

6.

DEVICE AND METHOD FOR FORCE PHENOTYPING OF CELLS FOR HIGH-THROUGHPUT SCREENING AND ANALYSIS

      
Application Number 17033488
Status Pending
Filing Date 2020-09-25
First Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Di Carlo, Dino
  • Tseng, Peter
  • Pushkarsky, Ivan

Abstract

A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/487 - Physical analysis of biological material of liquid biological material

7.

SEMANTIC INTERIOR MAPOLOGY: A TOOL BOX FOR INDOOR SCENE DESCRIPTION FROM ARCHITECTURAL FLOOR PLANS

      
Application Number 16932438
Status Pending
Filing Date 2020-07-17
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Trinh, Viet
  • Manduchi, Roberto

Abstract

A computer implemented method or system including a map conversion toolkit and a map Population toolkit. The map conversion toolkit allows one to quickly trace the layout of a floor plan, generating a file (e.g., GeoJSON file) that can be rendered in two dimensions (2D) or three dimensions (3D) using web tools such as Mapbox. The map population toolkit takes the scan (e.g., 3D scan) of a room in the building (taken from an RGB-D camera), and, through a semi- automatic process, generates individual objects, which are correctly dimensioned and positioned in the (e.g., GeoJSON) representation of the building. In another example, a computer implemented method for diagraming a space comprises obtaining a layout of the space; and annotating or decorating the layout with meaningful labels that are translatable to glanceable visual signals or audio signals.

IPC Classes  ?

  • G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
  • G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation

8.

SYSTEM AND METHOD FOR OPTIMIZING HYDROCARBON PRODUCTION FROM SUBSURFACE RESERVOIRS

      
Application Number 16516016
Status Pending
Filing Date 2019-07-18
First Publication Date 2021-01-21
Owner
  • Chevron U.S.A. Inc. (USA)
  • The Regents of the University of California (USA)
Inventor
  • Hoversten, Gary Michael
  • Commer, Michael

Abstract

A method is described for subsurface hydrocarbon reservoir characterization including receiving a time-lapse electromagnetic (EM) dataset and a flow dataset; inverting the time-lapse EM dataset using a parametric inversion that models steel well casings to determine a volume of fluid-changed reservoir; inverting the time-lapse EM dataset and the flow dataset using a joint inversion that honors the volume of the fluid-changed reservoir to determine relative permeability and capillary pressure; and characterizing flow characteristics in the volume of the fluid-changed reservoir. The method may be executed by a computer system.

IPC Classes  ?

  • G01V 3/38 - Processing data, e.g. for analysis, for interpretation or for correction
  • G01V 3/30 - Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination or deviation specially adapted for well-logging operating with electromagnetic waves
  • E21B 49/00 - Testing the nature of borehole walls; Formation testing; Methods or apparatus for obtaining samples of soil or well fluids, specially adapted to earth drilling or wells
  • E21B 41/00 - Equipment or details not covered by groups

9.

COMBINATION CANCER THERAPY AGENTS AND METHODS

      
Application Number US2020042453
Publication Number 2021/011844
Status In Force
Filing Date 2020-07-17
Publication Date 2021-01-21
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventor
  • Dubinett, Steven, S.
  • Liu, Bin
  • Lim, Raymond
  • Salehi-Rad, Ramin

Abstract

The present disclosure relates, in general, to methods for treating cancer comprising administering to a subject in need thereof an effective amount of CXCL9, CXCL10 or the combination, in combination with an immune checkpoint inhibitor. The CXCL9, CXCL10 or combination may be administered as a polypeptide, a polynucleotide or cells comprising a polynucleotide encoding CXCL9, CXCL10 or both. In one aspect, the treatment is amenable to patients with low or high mutational burden tumors.

IPC Classes  ?

  • A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

10.

PLANTS WITH ENHANCED RESISTANCE TO BACTERIAL PATHOGENS

      
Application Number US2020041531
Publication Number 2021/011348
Status In Force
Filing Date 2020-07-10
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Dahlbeck, Douglas
  • Ortega, Arturo
  • Schultink, Alex
  • Staskawicz, Brian, J.

Abstract

Bs5Bs5-likeBs5-like gene that are capable of conferring to plants comprising the alleles enhanced resistance to plant pathogens. The present invention further provides methods of using the plants and seeds in agricultural production to limit plant diseases caused by plant pathogens.

IPC Classes  ?

  • A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

11.

NANOPOROUS LITHIUM VANADIUM FLUOROPHOSPHATE MATERIALS AND CATHODES FOR FAST CHARGING LI-ION BATTERIES

      
Application Number US2020042394
Publication Number 2021/011811
Status In Force
Filing Date 2020-07-16
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Tolbert, Sarah H.
  • Lin, Terri C.

Abstract

Nanoporous carbon coated lithium vanadium fluorophosphate materials and cathodes for fast charging li-ion batteries are described. Formation of the materials using polymer-templating is also described.

IPC Classes  ?

  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
  • H01M 4/04 - Processes of manufacture in general
  • H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy

12.

COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS

      
Application Number US2020042542
Publication Number 2021/011875
Status In Force
Filing Date 2020-07-17
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Li, Huiying
  • Barnard, Emma

Abstract

Provided herein are methods and compositions for the treatment or prevention of a skin disease (e.g., acne) in a subject by administering to the subject a composition comprising iron or cobalt.

IPC Classes  ?

  • A61K 33/24 - Heavy metals; Compounds thereof
  • A61K 33/26 - Iron; Compounds thereof
  • A61K 35/741 - Probiotics
  • A61Q 19/08 - Anti-ageing preparations
  • A61P 17/10 - Anti-acne agents
  • A61K 8/99 - Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
  • A61K 8/19 - Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients
  • A61K 2300/00 -

13.

LITHIUM-EXCESS TRANSITION-METAL-DEFICIENT SPINELS FOR FAST CHARGING/DISCHARGING LITHIUM-ION BATTERY MATERIALS

      
Application Number US2020041941
Publication Number 2021/011542
Status In Force
Filing Date 2020-07-14
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Ceder, Gerbrand
  • Ji, Huiwen

Abstract

1+x2-y4-zzz where 0.2 ≤ x ≤ 1, 0.2 ≤ y ≤ 0.6, and 0 ≤ z ≤ 0.8; and TM is Mn, Ni, Co, Al, Sc, Ti, Zr, Mg, Nb, or a mixture thereof. The spinels achieve a higher gravimetric energy density than traditional spinels while still retaining high capacity at an extremely fast charging/discharging rate.

IPC Classes  ?

14.

MIXED SIGNAL NEUROMORPHIC COMPUTING WITH NONVOLATILE MEMORY DEVICES

      
Application Number 16608006
Status Pending
Filing Date 2018-04-27
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Strukov, Dmitri
  • Bayat, Farnood Merrikh
  • Bavandpour, Mohammad
  • Mahmoodi, Mohammad Reza
  • Guo, Xinjie

Abstract

Building blocks for implementing Vector-by-Matrix Multiplication (VMM) are implemented with analog circuitry including non-volatile memory devices (flash transistors) and using in-memory computation. In one example, improved performance and more accurate VMM is achieved in arrays including multi-gate flash transistors when computation uses a control gate or the combination of control gate and word line (instead of using the word line alone). In another example, very fast weight programming of the arrays is achieved using a novel programming protocol. In yet another example, higher density and faster array programming is achieved when the gate(s) responsible for erasing devices, or the source line, are re-routed across different rows, e.g., in a zigzag form. In yet another embodiment a neural network is provided with nonlinear synaptic weights implemented with nonvolatile memory devices.

IPC Classes  ?

  • G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G11C 16/04 - Erasable programmable read-only memories electrically programmable using variable threshold transistors, e.g. FAMOS

15.

Multi-Spectral THz Micro-Doppler Radar Based on Silicon-Based Picosecond Pulse Radiators

      
Application Number 16931936
Status Pending
Filing Date 2020-07-17
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Babakhani, Aydin
  • Razavian, Seyedmohammadreza
  • Assefzadeh, Mahdi
  • Hosseini, Mostafa

Abstract

Systems and methods for modulation and demodulation using a micro-Doppler effect are described. In an embodiment, the method includes radiating, using a picosecond pulse generator with an antenna, a train of THz pulses that form a frequency comb, where the frequency comb is reflected from an object such that the frequency several tones in the frequency comb are shifted based on the speed of the object and demodulating the reflected frequency comb to recover a THz Doppler signature of the object.

IPC Classes  ?

  • G01S 13/50 - Systems of measurement based on relative movement of target
  • G01S 7/28 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group - Details of pulse systems

16.

VAN DER WAALS INTEGRATION APPROACH FOR MATERIAL INTEGRATION AND DEVICE FABRICATION

      
Application Number 16982477
Status Pending
Filing Date 2019-03-19
First Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Duan, Xiangfeng
  • Huang, Yu
  • Liu, Yuan

Abstract

An electronic or optoelectronic device includes: (1) a layer of a first material; and (2) a layer of a second material disposed on the layer of the first material, wherein the first material is different from the second material, and the layer of the first material is spaced from the layer of the second material by a gap.

IPC Classes  ?

  • H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
  • H01L 51/05 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for rectifying, amplifying, oscillating or switching and having at least one potential-jump barrier or surface barrier; Capacitors or resistors with at least one potential-jump barrier or surface barrier
  • H01L 29/786 - Thin-film transistors
  • H01L 29/66 - Types of semiconductor device

17.

BAMBAM: PARALLEL COMPARATIVE ANALYSIS OF HIGH-THROUGHPUT SEQUENCING DATA

      
Application Number 17025525
Status Pending
Filing Date 2020-09-18
First Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Sanborn, John Zachary
  • Haussler, David

Abstract

The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.

IPC Classes  ?

  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G06F 40/169 - Annotation, e.g. comment data or footnotes
  • G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object or an image, setting a parameter value or selecting a range
  • G06T 11/20 - Drawing from basic elements, e.g. lines or circles
  • G06N 7/00 - Computer systems based on specific mathematical models
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

18.

VIRTUAL TILE ROUTING FOR NAVIGATING COMPLEX TRANSIT HUBS

      
Application Number 16932301
Status Pending
Filing Date 2020-07-17
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Lam, Jonathan
  • Mirzaei, Fatemeh
  • Manduchi, Roberto

Abstract

A computer implemented method or system for creating a route for navigating a transit hub or plaza using an application executing on a user's mobile device. The application accesses a tessellated map comprising first tiles each including a different area of interest on the map; and second tiles including a walkable area connecting the different areas of interest. The application highlights one of the first tiles including one of the different areas of interest selected using input from the user; highlights one of the second tiles including a location of the mobile device on the map; and highlights a series of the second tiles linking the location to the one of the areas of interest. A method of creating the tessellated map is also disclosed.

IPC Classes  ?

  • G01C 21/34 - Route searching; Route guidance
  • G01C 21/36 - Input/output arrangements for on-board computers
  • G01C 21/28 - Navigation; Navigational instruments not provided for in groups specially adapted for navigation in a road network with correlation of data from several navigational instruments

19.

COMPOSITIONS FOR EXPANDING REGULATORY T CELLS (TREG), AND TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES AND CONDITIONS

      
Application Number 16989816
Status Pending
Filing Date 2020-08-10
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor Franco, Alessandra

Abstract

Provided are compositions, including isolated, synthetic or recombinant peptides for: expanding regulatory T cells (Treg) populations; for treating or ameliorating a vascular inflammation, and Kawasaki disease (KD) or a pediatric acute vasculitis of the coronary arteries, including vascular coronary abnormalities, and acute or chronic vascular inflammatory abnormalities, and method for making and using them. Provided are immunotherapies for promoting expansion of natural, Treg to establish, or re-establish, vascular homeostasis; or, for ameliorating: a disease or condition associated with an autoimmune disease or condition; as immune-mediated vascular disorder; a disease or condition treated with intravenous immunoglobulin (IVIG) therapy; a vascular coronary abnormality; an acute or a chronic vasculitis; an autoimmune vasculitis; Kawasaki disease (KD) or a pediatric acute vasculitis of the coronary arteries; atherosclerosis; preventing miscarriage in autoimmune women; rheumatoid arthritis or Juvenile Idiopathic Arthritis; a neoplastic hematological disorder, or a leukemia.

IPC Classes  ?

  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 9/127 - Liposomes
  • A61K 9/14 - Particulate form, e.g. powders

20.

IMPROVED PEPPER PLANTS

      
Application Number 17042467
Status Pending
Filing Date 2019-03-29
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Van Deynze, Allen E.
  • Hill, Theresa A.

Abstract

The present invention provides methods of preparing a cultivated pepper plant bearing fruit having a low destemming force, as well as methods of preparing a cultivated pepper plant bearing clustered fruit. The invention also provides cultivated pepper plants prepared by these methods.

IPC Classes  ?

21.

DIGITAL WATERMARKING OF MACHINE LEARNING MODELS

      
Application Number 17042773
Status Pending
Filing Date 2019-03-21
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Rouhani, Bita Darvish
  • Chen, Huili
  • Koushanfar, Farinaz

Abstract

A method may include embedding, in a hidden layer and/or an output layer of a first machine learning model, a first digital watermark. The first digital watermark may correspond to input samples altering the low probabilistic regions of an activation map associated with the hidden layer of the first machine learning model. Alternatively, the first digital watermark may correspond to input samples rarely encountered by the first machine learning model. The first digital watermark may be embedded in the first machine learning model by at least training, based on training data including the input samples, the first machine learning model. A second machine learning model may be determined to be a duplicate of the first machine learning model based on a comparison of the first digital watermark embedded in the first machine learning model and a second digital watermark extracted from the second machine learning model.

IPC Classes  ?

  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
  • G06N 7/00 - Computer systems based on specific mathematical models
  • G06F 21/16 - Program or content traceability, e.g. by watermarking

22.

CASZ COMPOSITIONS AND METHODS OF USE

      
Application Number 17032521
Status Pending
Filing Date 2020-09-25
First Publication Date 2021-01-21
Owner The Regents of the University of California (USA)
Inventor
  • Doudna, Jennifer A.
  • Burstein, David
  • Chen, Janice S.
  • Harrington, Lucas B.
  • Paez-Espino, David
  • Banfield, Jillian F.

Abstract

Provided are compositions and methods that include one or more of: (1) a “CasZ” protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a “CasZ trancRNA”), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same).

IPC Classes  ?

  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

23.

SHORT CONJUGATED OLIGOELECTROLYTES AND USES THEREOF

      
Application Number 17040320
Status Pending
Filing Date 2019-03-21
First Publication Date 2021-01-21
Owner The Regents Of The University Of California (USA)
Inventor
  • Bazan, Guillermo
  • Zhang, Zichao
  • Moreland, Alex
  • Mahan, Michael J.
  • Heithoff, Douglas M.
  • Limwongyut, Jakkarin
  • Nie, Chenyao

Abstract

Compositions and methods of making and using thereof are provided with a specific antimicrobial activity and efficacy toward Gram-positive and Gram-negative bacteria and low levels of toxicity toward mammalian cells. The compositions include water-soluble molecules characterized by a hydrophobic interior fragment and side groups containing cationic groups. A class of these molecules is provided with variations in the length of the internal conjugated segment and in other molecular features, which impact the efficacy and toxicity. The substituents on the cationic functional group, the structural variations on the solubilizing group, and the length of the conjugated segment are important features affecting the antimicrobial property and the non-toxicity to mammalian cells of the composition.

IPC Classes  ?

  • C07D 471/08 - Bridged systems
  • A61P 31/04 - Antibacterial agents
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07C 217/62 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
  • C07C 279/08 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
  • C07C 309/24 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings

24.

VIRUS BIORESISTORS

      
Application Number 17043191
Status Pending
Filing Date 2019-03-29
First Publication Date 2021-01-21
Owner
  • The Regents of the University of California (USA)
  • Phagetech, Inc. (USA)
Inventor
  • Penner, Reginald M.
  • Ogata, Alana F.
  • Bhasin, Apurva
  • Weiss, Gregory A.
  • Tam, Phillip
  • Briggs, Jeffrey Scott
  • Yap-True, Marie
  • Attar, Aisha
  • Patterson, Shae Victoria

Abstract

Provided herein are, inter alia, biosensors and electrochemical cells comprising electronically conductive polymers and viral particles; diagnostic kits; and methods of detecting compounds in samples.

IPC Classes  ?

  • G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • G01N 27/327 - Biochemical electrodes
  • G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance

25.

BIOLOGICALLY INSPIRED SLEEP ALGORITHM FOR ARTIFICIAL NEURAL NETWORKS

      
Application Number US2020042686
Publication Number 2021/011931
Status In Force
Filing Date 2020-07-17
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Bazhenov, Maksim
  • Krishnan, Giri Prashanth
  • Tadros, Timothy

Abstract

Systems and methods for generating Artificial Neural Networks (ANNs) based on the principles of biological sleep are disclosed. Namely, the systems and methods can be configured to apply a sleep-like phase to ANNs which enables training to be generalized, performance to be improved, and catastrophic forgetting for sequential multi-task training to be prevented. Various implementations of these systems and methods can be configured to: (i) train an ANN using backpropagation algorithm, (ii) convert the architecture of the ANN to an equivalent Spiking Neural Network (SNN) and simulate a sleep phase in the SNN while using plasticity rules to modify synaptic weights, and (iii) convert the modified synaptic weights associated with the simulated sleep phase of the SNN back into the ANN. This transformation from ANN to SNN to ANN effectively emulates learning mechanisms actuated during biological sleep and, as such, overcomes limitations commonly associated with machine learning.

IPC Classes  ?

  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
  • G06N 3/08 - Learning methods

26.

ULTRAFAST TRACER IMAGING FOR POSITRON EMISSION TOMOGRAPHY

      
Application Number US2020042401
Publication Number 2021/011815
Status In Force
Filing Date 2020-07-16
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Zhang, Xuezhu
  • Qi, Jinyi
  • Cherry, Simon R.
  • Badawi, Ramsey D.
  • Wang, Guobao

Abstract

The disclosed embodiments relate to a system that performs ultra-fast tracer imaging on a subject using positron emission tomography. During operation, the system performs a high-temporal-resolution, total-body dynamic PET scan on the subject as an intravenously injected radioactive tracer propagates through the vascular system of the subject to produce PET projection data. Next, the system applies an image reconstruction technique to the PET projection data to produce subsecond temporal frames, which illustrate the dynamic propagation of the radioactive tracer through the vascular system of the subject. Finally, the system outputs the temporal frames through a display device.

IPC Classes  ?

  • A61B 6/03 - Computerised tomographs
  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/08 - Measuring devices for evaluating the respiratory organs
  • G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting

27.

HUMAN MILK OLIGOSACCHARIDES FOR CONTROL OF DIETARY RESPONSE AND METABOLIC PHENOTYPE

      
Application Number US2020042630
Publication Number 2021/011905
Status In Force
Filing Date 2020-07-17
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Barile, Daniela
  • Lee, Sunhye
  • Raybould, Helen

Abstract

Provided herein are method for modulating dietary response in a subject. The methods include the administration of human milk oligosaccharides such as 2'-fucosyllactose to the subject. Dietary responses such as decreased adiposity, preservation of lean muscle mass, improved cognitive function, and reduced levels of inflammatory factors can be obtained in various populations, including those consuming high fat diets.

IPC Classes  ?

  • A23L 29/30 - Foods or foodstuffs containing additives; Preparation or treatment thereof containing starch hydrolysates, e.g. dextrin
  • A23L 33/00 - Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A61K 31/702 - Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

28.

UNIVERSAL CHIMERIC ANTIGEN RECEPTORS AND METHODS FOR MAKING AND USING THEM

      
Application Number US2020042345
Publication Number 2021/011781
Status In Force
Filing Date 2020-07-16
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Wang, Yingxiao
  • Limsakul, Praopim
  • Wu, Yiqian

Abstract

In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for engineering immune effector cells, e.g., T cells, NK cells, monocytes and/or macrophages to recognize and destroy a desired target cell, which can be a cancer cell, a dysfunctional cell, or an infected cell.

IPC Classes  ?

  • A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
  • C12N 15/09 - Recombinant DNA-technology
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells

29.

CLAUDIN18 ANTIBODIES AND METHODS OF TREATING CANCER

      
Application Number US2020042573
Publication Number 2021/011885
Status In Force
Filing Date 2020-07-17
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Mcdermott, Martina, S.
  • O'Brien, Neil, A.

Abstract

The present disclosure provides antigen-binding proteins which bind to Claudin- 18.2 (CLDN18.2); bispecific antigen-binding proteins which bind to CLDN18.2 and a second antigen; and conjugates thereof. In various aspects, the antigen-binding proteins bind to Extracellular Loop 1 (ELI) of the extracellular domain of CLDN18.2. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.

IPC Classes  ?

  • C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
  • A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61P 35/00 - Antineoplastic agents
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

30.

SYSTEMS AND METHODS FOR MEMORY SPECIFICITY WITH VIRTUAL REALITY

      
Application Number US2020041645
Publication Number 2021/011391
Status In Force
Filing Date 2020-07-10
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Craske, Michelle, G.
  • Treanor, Michael

Abstract

Systems and methods for virtualized treatments in accordance with embodiments of the invention are illustrated. One embodiment includes a method for providing a virtualized treatment experience. The method includes steps for generating a treatment sequence includes a plurality of treatment elements, generating a virtualized environment for the generated treatment sequence, providing a plurality of treatment elements within the virtualized environment, and providing a set of one or more prompts for at least one treatment element of the plurality of treatment elements.

IPC Classes  ?

  • A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
  • A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

31.

CHEMICALLY CONTROLLED MONOCLONAL ANTIBODY TARGET ENGAGEMENT

      
Application Number US2020041710
Publication Number 2021/011417
Status In Force
Filing Date 2020-07-10
Publication Date 2021-01-21
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Craik, Charles S.
  • Shokat, Kevan M.
  • Zhang, Ziyang
  • Rohweder, Peter J.

Abstract

The present disclosure relates generally to antibodies reactive with tumor-specific neoantigens, as well as neoantigen-binding fragments thereof. The present disclosure also relates to nucleic acids, expression cassettes, and expression vectors encoding the antibodies and neoantigen-binding fragments. The antibodies and neoantigen binding-fragments are useful for diagnosis and treatment of cancer.

IPC Classes  ?

  • C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
  • A61P 35/00 - Antineoplastic agents
  • G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

32.

ANTI-CANCER COMPOUNDS

      
Application Number 16790287
Status Pending
Filing Date 2020-02-13
First Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Peto, Csaba J.
  • Jablons, David
  • Lemjabbar-Alaoui, Hassan

Abstract

This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

IPC Classes  ?

  • C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • A61K 31/502 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
  • A61P 35/00 - Antineoplastic agents
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

33.

PEER-TO-PEER TRAINING OF A MACHINE LEARNING MODEL

      
Application Number 16926534
Status Pending
Filing Date 2020-07-10
First Publication Date 2021-01-14
Owner The Regents of the University of California (USA)
Inventor
  • Lalitha, Anusha
  • Javidi, Tara
  • Koushanfar, Farinaz
  • Kilinc, Osman Cihan

Abstract

A method may include training, based on a first training data available at a first node in a network, a first local machine learning model. A first local belief of a parameter set of a global machine learning model may be updated based on the training of the first local machine learning model. A second local belief of the parameter set of the global machine learning model may be received from a second node in the network. The second local belief may have been updated based on the second node training a second local machine learning model. The second local machine learning model may be trained based on a second training data available at the second node. The first local belief may be updated based on the second local belief of the second node. Related systems and articles of manufacture, including computer program products, are also provided.

IPC Classes  ?

34.

TRUNK SUPPORTING EXOSKELETON AND METHOD OF USE

      
Application Number 17038328
Status Pending
Filing Date 2020-09-30
First Publication Date 2021-01-14
Owner The Regents of the University of California (USA)
Inventor
  • Kazerooni, Homayoon
  • Hacker, Erich
  • Chen, Lee-Huang

Abstract

An exoskeleton includes two torque generators, two thigh links, and a supporting trunk rotatably coupled to the thigh links. When a wearer bends forward in the sagittal plane such that the supporting trunk extends beyond a predetermined angle A with respect to vertical, at least one of the torque generators imposes a resisting torque between the supporting trunk and a corresponding thigh link, thus imposing a force onto a wearer's trunk and thighs to aid in supporting the wearer in a bent position. The exoskeleton may include an active or passive means for actuating the generators. When the supporting trunk does not extend beyond the predetermined angle A, the torque generators do not impose resisting torques between the supporting trunk and the thigh links during the entire range of motion of the thigh links, thus enabling a wearer to walk, run and sit without constraint while in an upright position.

IPC Classes  ?

35.

Compounds and Compositions for the Treatment of Cancer

      
Application Number 16305377
Status Pending
Filing Date 2017-06-28
First Publication Date 2021-01-14
Owner
  • The Regents of the University of California (USA)
  • Rescue Therapeutics, Inc. (USA)
Inventor
  • Peto, Csaba
  • Tolani, Bhairavi
  • Woodard, Gavitt
  • Tsang, Tsze
  • Mann, Michael
  • Jablons, David M.
  • He, Biao

Abstract

The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof.

IPC Classes  ?

  • C07D 231/06 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
  • C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond

36.

CHELATING MOLECULES

      
Application Number 16336665
Status Pending
Filing Date 2017-08-28
First Publication Date 2021-01-14
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • FRED HUTCHINSON CANCER RESEARCH CENTER (USA)
Inventor
  • Abergel, Rebecca J.
  • Rees, Julian
  • Strong, Roland K.
  • Captain, Llya

Abstract

Provided herein are a variety of metal chelators as well as methods of use thereof.

IPC Classes  ?

  • C07C 235/60 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
  • A61K 51/04 - Organic compounds
  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
  • A61K 38/07 - Tetrapeptides
  • C07D 213/89 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

37.

MAGNETIC MEMORY STRUCTURES USING ELECTRIC-FIELD CONTROLLED INTERLAYER EXCHANGE COUPLING (IEC) FOR MAGNETIZATION SWITCHING

      
Application Number 16510343
Status Pending
Filing Date 2019-07-12
First Publication Date 2021-01-14
Owner The Regents of the University of California (USA)
Inventor
  • Salahuddin, Sayeef
  • Sayed, Shehrin

Abstract

A magnetic memory structure employs electric-field controlled interlayer exchange coupling between a free magnetic layer and a fixed magnetic layer to switch a magnetization direction. The magnetic layers are separated by a spacer layer disposed between two oxide layers. The spacer layer exhibits a large IEC while the oxide layers provide tunnel barriers, forming a quantum-well between the magnetic layers with discrete energy states above the equilibrium Fermi level. When an electric field is applied across the structure, the tunnel barriers become transparent at discrete energy states via a resonant tunneling phenomenon. The wave functions of the two magnets then can interact and interfere to provide a sizable IEC. IEC can control the magnetization direction of the free magnetic layer relative to the magnetization direction of the fixed magnetic layer depending on the sign of the IEC, induced by a magnitude of the applied electric field above a threshold value.

IPC Classes  ?

  • H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
  • H01L 43/10 - Selection of materials
  • H01L 43/02 - Devices using galvano-magnetic or similar magnetic effects; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details
  • G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect

38.

A WIRELESSLY POWERED FREQUENCY-SWEPT SPECTROSCOPY SENSOR

      
Application Number US2020040283
Publication Number 2021/007071
Status In Force
Filing Date 2020-06-30
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Babakhani, Aydin
  • Sun, Yuxiang

Abstract

Systems and methods in accordance with embodiments of the invention implement wirelessly powered frequency-swept spectroscopy sensors. One embodiment includes a first antenna configured to receive an incoming signal; an energy-harvesting circuit configured to produce DC energy; a power management unit; an on-chip signal source configured to use the incoming signal as a locking signal; and a second antenna configured to transmit back a signal locked to the frequency of the incoming signal. In a further embodiment, the wirelessly powered frequency-swept spectroscopy sensor includes a third antenna, where the third antenna is on-chip.

IPC Classes  ?

  • G01J 3/00 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours
  • G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details

39.

SYSTEMS AND METHODS FOR LONG-DISTANCE REMOTE SENSING WITH SUB-WAVELENGTH RESOLUTION USING A WIRELESSLY-POWERED SENSOR TAG ARRAY

      
Application Number US2020041007
Publication Number 2021/007210
Status In Force
Filing Date 2020-07-07
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Lyu, Hongming
  • Babakhani, Aydin

Abstract

Systems and methods for remote sensing are described. In an embodiment, an apparatus, includes: a radio frequency identification (RFID) tag; an electromagnetic transmitter configured to emit electromagnetic waves; an ultra-wideband (UWB) receiver; a computer system; where: the RFID tag is configured to be operated without a battery, and to be powered by the electromagnetic waves emitted by the electromagnetic transmitter; where the RFID tag is configured to send out UWB impulses based on an amount of electromagnetic power received from the electromagnetic transmitter, such that a repetition rate of the UWB impulses varies with the amount of electromagnetic power received from the electromagnetic transmitter

IPC Classes  ?

  • H04Q 5/22 - Selecting arrangements wherein two or more subscriber stations are connected by the same line to the exchange with indirect connection, i.e. through subordinate switching centre the subordinate centre not permitting interconnection of subscribers connected thereto

40.

METHODS FOR IMPROVED REGENERATION OF TRANSGENIC PLANTS USING GROWTH-REGULATING FACTOR (GRF), GRF-INTERACTING FACTOR (GIF), OR CHIMERIC GRF-GIF GENES AND PROTEINS

      
Application Number US2020041135
Publication Number 2021/007284
Status In Force
Filing Date 2020-07-08
Publication Date 2021-01-14
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (Argentina)
Inventor
  • Dubcovsky, Jorge
  • Debernardi, Juan Manuel
  • Tricoli, David
  • Palatnik, Javier

Abstract

GRFGRFGIFGRFGIFGIF genes and proteins. The disclosure also provides plants with an improved regeneration efficiency that are produced by the disclosed methods, methods of reducing the use of exogenous cytokinins in the regeneration of plants, and methods of improving the regeneration efficiency of plants.

IPC Classes  ?

  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

41.

LIPID-MODIFIED OLIGONUCLEOTIDES AND METHODS OF USING THE SAME

      
Application Number US2020041277
Publication Number 2021/007367
Status In Force
Filing Date 2020-07-08
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Gartner, Zev
  • Patterson, David
  • Chow, Eric
  • Weber, Robert
  • Mcginnis, Christopher

Abstract

The disclosure generally relates to methods and applications of single-cell barcoding and methods of nucleotide sequencing using composition comprising lipid-modified oligonucleotides.

IPC Classes  ?

  • C12P 9/00 - Preparation of organic compounds containing a metal or atom other than H, N, C, O, S, or halogen
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/6869 - Methods for sequencing

42.

PULSED-COHERENT ELECTRONIC FRONT END FOR LIDAR AND RADAR DETECTION AND RANGING

      
Application Number US2020041443
Publication Number 2021/007454
Status In Force
Filing Date 2020-07-09
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Yang, Chihkong
  • Chen, Liyang

Abstract

Systems and methods for a light detection and ranging (lidar) system utilizing both coherent and pulsed detection for Time of Flight (ToF) measurement are disclosed. In one embodiment, a lidar system includes a reference clock providing a clock signal (CKref) with time period Tcik, an automatic gain control (AGC) loop that is triggered when a received signal RFin is greater than a threshold voltage Vth, a coherent detector measuring a fine ToF by detecting the phase difference (ΔΦ) between the clock signal (CKref) and the received signal (RFin), a pulse edge detector measuring a coarse ToF by detecting a falling edge (post-edge) of the received signal (RFin) and counting cycles N to estimate an arrival time of N x Tcik, and a combiner that calculates total ToF by combining output of the coherent detector and pulse edge detector using the equation.

IPC Classes  ?

  • G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves
  • G01S 17/32 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated
  • G01S 17/36 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal

43.

USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION

      
Application Number 16863892
Status Pending
Filing Date 2020-04-30
First Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Haudenschild, Dominik
  • Di Cesare, Paul
  • Yik, Jasper
  • Christiansen, Blaine

Abstract

The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.

IPC Classes  ?

  • A61K 31/453 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • A01N 1/02 - Preservation of living parts
  • A61K 9/00 - Medicinal preparations characterised by special physical form

44.

HOUSING FOR STORAGE AND MANIPULATION OF A SURGICAL GUIDE WIRE

      
Application Number 16911855
Status Pending
Filing Date 2020-06-25
First Publication Date 2021-01-14
Owner The Regents of the University of California (USA)
Inventor Wehbi, Elias

Abstract

A housing has a spiral passageway which contains a catheter which may be manually extracted from the housing by means of a wheel having a polygonal or otherwise textured circumferential surface and mounted on a shaft which extends through a non-circular bearing defined in an outer portion of the housing. An inner portion of the wheel extends into the spiral passageway adjacent the wire catheter and an outer portion of the wheel outwardly from the housing whereby the upper surface of the knob can be manipulated by a member of the surgical team in one direction and the wire catheter below the knob will be advanced in the opposite direction. The non-circular bearing has a generally circular outer portion in which the textured surface of the knob is only intermittently in contact with the catheter whereby the wire catheter may be advanced, and a generally linear inner portion sloping inwardly towards the catheter. When the knob's shaft is held loosely in the outer portion of the bearing, the wire catheter is free to travel. However when the knob's shaft is moved into the sloping portion of the bearing, the operator can push the knob in one direction to force the knob against the wire catheter and lock the catheter into intimate contact with the lower surface of the passageway, and in the opposite direction to retract the knob slightly away from the catheter thereby permitting limited movement of the catheter relative to the housing.

IPC Classes  ?

45.

FULLY AUTOMATED FOUR-CHAMBER SEGMENTATION OF ECHOCARDIOGRAMS

      
Application Number 16926517
Status Pending
Filing Date 2020-07-10
First Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Arafati, Arghavan
  • Jafarkhani, Hamid
  • Kheradvar, Arash

Abstract

Devices, systems and methods related to techniques for performing four-chamber segmentation of echocardiograms are disclosed. In one example aspect, a method for generating segmented image data based on an input echocardiogram includes receiving an input echocardiogram that includes information associated with four chambers of a heart, performing segmentation on the information associated with the four chambers using an adversarial model that comprises a first artificial neural network with multiple layers, and combining data from selected layers of the first artificial neural network to generate an output image that includes the segmented four chambers of the heart.

IPC Classes  ?

  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G06N 3/08 - Learning methods

46.

OPTICAL CAVITY PCR

      
Application Number 16938197
Status Pending
Filing Date 2020-07-24
First Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Lee, Luke P.
  • Son, Jun Ho

Abstract

An LED-driven optical cavity PCR system and method is disclosed for fast, accurate and reliable PCR based diagnostics. An optical cavity comprising two thin light absorbing metal (AU) films is used for uniform light absorption and subsequent photo thermal light-to-heat conversion is employed for PCR thermal cycling.

IPC Classes  ?

  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12Q 1/686 - Polymerase chain reaction [PCR]

47.

ESTROGEN RECEPTOR LIGAND TREATMENT FOR NEURODEGENERATIVE DISEASES

      
Application Number 16938577
Status Pending
Filing Date 2020-07-24
First Publication Date 2021-01-14
Owner The Regents of the University of California (USA)
Inventor Voskuhl, Rhonda R.

Abstract

The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ERβ) ligand.

IPC Classes  ?

  • A61K 31/05 - Phenols
  • C07D 307/93 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
  • C07D 487/04 - Ortho-condensed systems
  • C07D 307/82 - Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
  • A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
  • A61K 31/225 - Polycarboxylic acids
  • A61K 38/21 - Interferons
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • C07C 39/42 - Halogenated derivatives containing six-membered aromatic rings and other rings
  • A61K 38/13 - Cyclosporins

48.

METHOD OF FABRICATING NON-POLAR AND SEMI-POLAR DEVICES USING EPITAXIAL LATERAL OVERGROWTH

      
Application Number 16978493
Status Pending
Filing Date 2019-04-01
First Publication Date 2021-01-14
Owner The Regents of the University of California (USA)
Inventor
  • Kamikawa, Takeshi
  • Gandrothula, Srinivas
  • Li, Hongjian

Abstract

A method of fabricating a semiconductor device, comprising: forming a growth restrict mask on or above a III-nitride substrate, and growing one or more island-like III-nitride semiconductor layers on the III-nitride substrate using the growth restrict mask The III-nitride substrate has an in-plane distribution of off-angle orientations with more than 0.1 degree; and the off-angle orientations of an m-plane oriented crystalline surface plane range from about +28 degrees to about −47 degrees towards a c-plane. The island-like III-nitride semiconductor layers have at least one long side and short side, wherein the long side is perpendicular to an a-axis of the island-like III-nitride semiconductor layers. The island-like III-nitride semiconductor layers do not coalesce with neighboring island-like III-nitride semiconductor layers.

IPC Classes  ?

  • H01L 33/00 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof
  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
  • H01L 33/18 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof characterised by the semiconductor bodies with a particular crystal structure or orientation, e.g. polycrystalline, amorphous or porous within the light emitting region
  • H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
  • H01L 29/04 - Semiconductor bodies characterised by their crystalline structure, e.g. polycrystalline, cubic or particular orientation of crystalline planes
  • H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
  • H01S 5/343 - Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well lasers [SQW-lasers], multiple quantum well lasers [MQW-lasers] or graded index separate confinement heterostructure lasers [GRINSCH-lasers] in AIIIBV compounds, e.g. AlGaAs-laser
  • H01S 5/22 - Structure or shape of the semiconductor body to guide the optical wave having a ridge or a stripe structure
  • H01S 5/042 - Electrical excitation
  • C30B 25/04 - Pattern deposit, e.g. by using masks
  • C30B 29/40 - AIIIBV compounds

49.

SYNTHETIC PLATELETS

      
Application Number 17030519
Status Pending
Filing Date 2020-09-24
First Publication Date 2021-01-14
Owner
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Mitragotri, Samir
  • Sarode, Apoorva
  • Gao, Yongsheng

Abstract

Provided herein are particles comprising a polymer substrate comprising one or more hyaluronic acid chains; and two or more peptide moieties bound directly to each hyaluronic acid chain. In some embodiments, the two or more peptide moieties comprising collagen-binding peptide (CBP) and von Willebrand binding peptide (VBP). The particles can be utilized in, e.g., methods of hemostatic treatment.

IPC Classes  ?

  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
  • A61P 7/02 - Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
  • A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
  • A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
  • A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

50.

COMPOUNDS AND METHODS FOR TREATING FIBROSIS OR CANCER

      
Application Number 16305172
Status Pending
Filing Date 2017-06-02
First Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Chapman, Harold A.
  • Wei, Ying
  • Backes, Bradley J.

Abstract

Provided herein, inter alia, are methods and compounds for treating a pulmonary disease, fibrosis, or cancer.

IPC Classes  ?

  • C07D 323/00 - Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
  • C07D 321/10 - Seven-membered rings condensed with carbocyclic rings or ring systems
  • C07D 273/01 - Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups having one nitrogen atom

51.

Photodiode

      
Application Number 16504724
Status Pending
Filing Date 2019-07-08
First Publication Date 2021-01-14
Owner
  • University College Cardiff Consultants Limited (United Kingdom)
  • The Regents of The University of California (USA)
  • University of Sheffield (United Kingdom)
Inventor
  • Liang, Baolai
  • Xie, Shiyu
  • Huffaker, Diana Lynne
  • David, John Paul Raj
  • Tan, Chee Hing

Abstract

In an example, an avalanche photodiode comprises a substrate and a structure comprising a first layer and a second layer, the first and second layers over and parallel to the substrate, wherein the first layer is between the substrate and the second layer. The first layer is an Aluminium Arsenide Antimonide multiplication layer, and wherein the cross-sectional area parallel to the substrate of the first layer is smaller than that of the second layer, thereby forming a recess in a sidewall of the structure.

IPC Classes  ?

  • H01L 31/107 - Devices sensitive to infra-red, visible or ultra-violet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
  • H01L 31/0216 - Coatings
  • H01L 31/0304 - Inorganic materials including, apart from doping materials or other impurities, only AIIIBV compounds
  • H01L 31/0352 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
  • H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

52.

SYNTHESIS OF EUROPIUM HALIDE PEROVSKITES IN SOLUTION PHASE

      
Application Number US2020040098
Publication Number 2021/007060
Status In Force
Filing Date 2020-06-29
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Yang, Peidong
  • Huang, Jianmei
  • Lei, Teng

Abstract

A solution phase synthesis process for preparing a rare earth perovskite, the process includes reacting an alkali metal material with a first surfactant ligand in the presence of a first solvent to obtain a first precursor complex solution; reacting a rare earth metal halide with a second surfactant ligand in the presence of a second solvent to obtain a second precursor complex solution; and reacting the first precursor complex solution with the second precursor complex solution in the presence of a third surfactant ligand and a third solvent to obtain the rare earth perovskite; wherein: the rare earth perovskite is in the form of nanocrystals; and the first solvent and third solvent comprise a non-coordinating solvent.

IPC Classes  ?

  • C30B 7/14 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
  • C30B 29/12 - Halides
  • C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
  • H01L 21/00 - Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof

53.

METHODS FOR SELECTIVELY MODIFYING AMINO ACIDS AND PRODUCTS MADE THEREBY

      
Application Number US2020040821
Publication Number 2021/007127
Status In Force
Filing Date 2020-07-03
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Chang, Michelle
  • Neugebauer, Monica E.
  • Benmaman, Jorge Marchand

Abstract

Disclosed herein are methods for the selective substitution of a hydrogen bonded to a carbon atom (e.g., a hydrogen of an aliphatic methylene group) of a compound, which comprise contacting the compound with a substituent in the presence of a BesD halogenase.

IPC Classes  ?

  • C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
  • C12P 13/06 - Alanine; Leucine; Isoleucine; Serine; Homoserine
  • C12P 13/08 - Lysine; Diaminopimelic acid; Threonine; Valine
  • C12P 13/10 - Citrulline; Arginine; Ornithine
  • C12P 21/00 - Preparation of peptides or proteins
  • C07K 14/36 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptomyces (G)
  • C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides

54.

WAVELENGTH SELECTIVE PHOSPHOR CONVERTING SYSTEM FOR LASER LIGHTING DEVICES

      
Application Number US2020040868
Publication Number 2021/007148
Status In Force
Filing Date 2020-07-06
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Reilly, Caroline E.
  • Lheureux, Guillaume
  • Weisbuch, Claude, C.A.

Abstract

2a255 5 ). The DBR has a structure with one or more repeating quarter-wavelength (λ /4) layers, while the FP resonator has a structure with one or more ?/4 layers surrounding a central half-wavelength (λ/2) cavity.

IPC Classes  ?

  • F21K 9/64 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction using wavelength conversion means distinct or spaced from the light-generating element, e.g. a remote phosphor layer
  • F21K 9/00 - Light sources using semiconductor devices as light-generating elements, e.g. using light-emitting diodes [LED] or lasers
  • F21K 9/60 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction
  • F21K 9/62 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction using mixing chambers, e.g. housings with reflective walls

55.

VARIANT TYPE V CRISPR/CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF

      
Application Number US2020040927
Publication Number 2021/007177
Status In Force
Filing Date 2020-07-06
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Doudna, Jennifer A.
  • Ma, Enbo
  • Liu, Junjie

Abstract

The present disclosure provides variant type V CRISPR/Cas effector polypeptides, nucleic acids encoding the variant polypeptides, and systems comprising the variant polypeptides or nucleic acids encoding same. The present disclosure provides methods for modifying a target nucleic acid, using a variant polypeptide of the present disclosure.

IPC Classes  ?

  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

56.

AUTOMATED RAPID ON-SITE EVALUATION MACHINE AND STAIN

      
Application Number US2020041421
Publication Number 2021/007443
Status In Force
Filing Date 2020-07-09
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Mendoza, Alejandro S.
  • Afify, Alaa M.
  • Lucero, Steven A.

Abstract

An automated rapid on-site evaluation (ROSE) system for smearing, staining and capturing a digital image of a biological sample such as a fine needle aspiration (FNA) sample is presented. The system comprises a housing with a user interface monitor or screen, a smearing system, a staining system, and an image capture system. The housing can further include a receiver for a biological sample that can direct the sample to a sample slide. The smearing system is configured to smear the sample on the sample slide. The staining system is configured to stain the sample. The image capture system is configured to capture a magnified image of the sample and store the digital image in the housing or remotely. The digital images may be available immediately for local or off-site review. The wait time between staining the sample and image capture can be less than 60 seconds.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides
  • G06K 9/46 - Extraction of features or characteristics of the image
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

57.

SYSTEMS AND METHODS FOR PRODUCING TUNABLE NOISE DAMPING MATERIAL STRUCTURES

      
Application Number US2020041649
Publication Number 2021/007538
Status In Force
Filing Date 2020-07-10
Publication Date 2021-01-14
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Candler, Robert, N.
  • Hopkins, Jonathan
  • Kavehpour, Hossein, Pirouz
  • Eldredge, Jeffrey, D.

Abstract

A tunable material structure that intuitively reacts to incoming sound impulses in varying degrees such that the material structure responds in such a manner so as to reduce the amplitude of the incoming pulse by utilizing more than one shape altering orifice to generate vortexes in the downstream flow.

IPC Classes  ?

  • A61F 11/08 - Protective devices for the ears internal, e.g. earplugs

58.

SYNTHETIC BIOLOGY TOOLS

      
Application Number 16789993
Status Pending
Filing Date 2020-02-13
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Lou, Chunbo
  • Moon, Tae Seok
  • Rhodius, Virgil
  • Stanton, Brynne
  • Tasmir, Alvin
  • Temme, Karsten
  • Voigt, Chris

Abstract

Methods for design of genetic circuits are provided.

IPC Classes  ?

  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
  • G16B 35/00 - ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
  • G16C 20/60 - In silico combinatorial chemistry
  • C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

59.

SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH

      
Application Number 16843783
Status Pending
Filing Date 2020-04-08
First Publication Date 2021-01-07
Owner
  • LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (USA)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Denardo, Sally J.
  • Denardo, Gerald L.
  • Balhorn, Rodney L.

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

IPC Classes  ?

  • A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
  • A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
  • A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

60.

PCR-Activated Sorting (PAS)

      
Application Number 16856343
Status Pending
Filing Date 2020-04-23
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Abate, Adam R.
  • Eastburn, Dennis Jay
  • Sciambi, Adam R.
  • Lim, Shaun

Abstract

The methods described herein, referred to as PCR-Activated Sorting (PAS), allow nucleic acids contained in biological systems to be sorted based on their sequence as detected with nucleic acid amplification techniques, e.g., PCR. The nucleic acids can be free floating or contained within living or nonliving structures, including particles, viruses, and cells. The nucleic acids can include, e.g., DNA or RNA. Systems and devices for use in practicing methods of the invention are also provided.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

61.

STRUCTURE-BASED PEPTIDE INHIBITORS OF ALPHA-SYNUCLEIN AGGREGATION

      
Application Number 16883515
Status Pending
Filing Date 2020-05-26
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Eisenberg, David S.
  • Sangwan, Smriti
  • Jiang, Lin

Abstract

This invention relates to inhibitory peptides which bind to α-synuclein molecules and inhibit α-synuclein amyloidogenic aggregation, α-synuclein cytotoxicity, and spread of α-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by α-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.

IPC Classes  ?

  • C07K 7/02 - Linear peptides containing at least one abnormal peptide link
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • A61P 25/16 - Anti-Parkinson drugs

62.

ADAPTIVE ANY-FUEL CAMLESS RECIPROCATING ENGINE

      
Application Number 16929544
Status Pending
Filing Date 2020-07-15
First Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Spearrin, Raymond Mitchell
  • Tsao, Tsu-Chin
  • Sinsheimer, Peter

Abstract

An adaptive, any-fuel reciprocating engine using sensor feedback integration of high-speed optical sensors with real-time control loops to adaptively manage the electronic actuation schemes over a range of engine loads and fuels. The engine uses one or more optical sensors to collect specific types of gas property data via a spectroscopic technique to adaptively control various components within the engine.

IPC Classes  ?

  • F02D 41/14 - Introducing closed-loop corrections
  • F01L 9/04 - Valve-gear or valve arrangements actuated non-mechanically by electric means
  • F02D 13/02 - Controlling the engine output power by varying inlet or exhaust valve operating characteristics, e.g. timing during engine operation
  • F02D 15/00 - Varying compression ratio
  • F02D 35/02 - Non-electrical control of engines, dependent on conditions exterior or interior to engines, not otherwise provided for on interior conditions
  • F02P 5/145 - Advancing or retarding electric ignition spark; Control therefor automatically, as a function of the working conditions of the engine or vehicle or of the atmospheric conditions using electrical means

63.

METHODS, SYSTEMS, AND COMPOSITIONS FOR DELIVERY OF NANOBUBBLES IN WATER TREATMENT SYSTEMS

      
Application Number 16931201
Status Pending
Filing Date 2020-07-16
First Publication Date 2021-01-07
Owner The Regents of The University of California (USA)
Inventor
  • Earthman, James C.
  • Misra, Mahendra K.
  • Slingsby, Stephen D.

Abstract

Methods, systems, and devices for water treatment or for preventing fouling of components of water treatment systems can include the upstream introduction of nanobubbles in-line and/or in close proximity to a reverse osmosis membrane in the water treatment system. The nanobubbles can bind to and cluster (flocculate) nanoparticles (and possible larger solid particles) so that they can be removed and not foul water purification components such as reverse osmosis membranes. The nanobubbles can also interact with and change some characteristics of nanoparticles and thereby reduce fouling of some system components, such as reverse osmosis membranes, or other components. The systems, methods, and devices disclosed herein can help produce potable water safe for human consumption in a more cost-effective manner, e.g., by reducing maintenance costs and in some cases manufacturing costs.

IPC Classes  ?

  • B01D 61/04 - Feed pretreatment
  • B01D 61/08 - Apparatus therefor
  • B01D 61/02 - Reverse osmosis; Hyperfiltration
  • B01D 65/08 - Prevention of membrane fouling or of concentration polarisation
  • C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
  • C02F 1/52 - Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities
  • C02F 1/00 - Treatment of water, waste water, or sewage
  • C02F 1/24 - Treatment of water, waste water, or sewage by flotation

64.

COMPOSITIONS AND METHODS INVOLVING ENGINEERED P27

      
Application Number 16977441
Status Pending
Filing Date 2019-04-10
First Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Rubin, Seth
  • Guiley, Keelan

Abstract

The disclosure provides polypeptides comprising an engineered p27, or a fragment thereof. Such polypeptides may be used to form trimeric protein complexes with a cyclin-dependent kinase 4 (Cdk4) (or a variant thereof) or Cdk6 (or a variant thereof), and a cyclin D (CycD) or a variant thereof.

IPC Classes  ?

  • C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
  • C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals

65.

DRUG DELIVERY FORMULATIONS

      
Application Number 16982891
Status Pending
Filing Date 2019-03-26
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Sailor, Michael J.
  • Hollett, Geoffrey Ian
  • Ingallinera, Thomas

Abstract

The disclosure provides drug delivery formulations that comprise a porous silicon material and a meltable compound, such as a progestin drug, or a meltable composition. The formulations provide for the controlled release of the progestin drug, or other therapeutic agent, over long time periods. In some embodiments, the meltable composition further comprises a melting point suppression agent, where the melting point suppression agent enables the loading of thermally unstable therapeutic agents into the porous silicon material by melt casting that would not otherwise be possible absent the melting point suppression agent. The disclosure additionally provides methods of making and using the drug delivery formulations.

IPC Classes  ?

  • A61K 9/16 - Agglomerates; Granulates; Microbeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
  • A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
  • A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

66.

Host cells and methods for producing toluene biochemically

      
Application Number 16286411
Status Pending
Filing Date 2019-02-26
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Beller, Harry R.
  • Rodrigues, Andria V.
  • Zargar, Kamrun

Abstract

The present invention provides for a genetically modified host cell comprising a first polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase, and having an enzymatic activity to decarboxylate a phenylacetic acid into a toluene and a carbon dioxide, and a second polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase activating enzyme, and having an enzymatic activity to cleave a S-adenosylmethionine (SAM) to form a methionine and a 5′-deoxyadenosyl radical.

IPC Classes  ?

  • C12P 5/00 - Preparation of hydrocarbons
  • C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
  • C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts
  • C12N 9/14 - Hydrolases (3.)

67.

MAGNETICALLY MODULATED COMPUTATIONAL CYTOMETER AND METHODS OF USE

      
Application Number US2020040664
Publication Number 2021/003369
Status In Force
Filing Date 2020-07-02
Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Ozcan, Aydogan
  • Ray, Aniruddha
  • Zhang, Yibo
  • Di Carlo, Dino

Abstract

A computational cytometer operates using magnetically modulated lensless speckle imaging, which introduces oscillatory motion to magnetic bead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three-dimensions (3D). Detection specificity is further enhanced through a deep learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network (P3D CNN), which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force. This compact, cost-effective and high-throughput computational cytometer can be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

IPC Classes  ?

  • G01N 15/10 - Investigating individual particles
  • B01D 35/06 - Filters making use of electricity or magnetism
  • B03C 1/005 - Pretreatment specially adapted for magnetic separation
  • B03C 1/02 - Magnetic separation acting directly on the substance being separated
  • B03C 1/32 - Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation

68.

STEM CELL-DERIVED EXOSOMES FOR THE TREATMENT OF CORNEAL SCARRING

      
Application Number 16977015
Status Pending
Filing Date 2019-03-04
First Publication Date 2021-01-07
Owner
  • University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
  • The Regents of the University of California (USA)
Inventor
  • Deng, Sophie Xiaohui
  • Funderburgh, James L.

Abstract

Corneal stromal scars are the leading cause of corneal blindness. The present invention relates to methods and compositions useful in therapies for this pathological condition. The invention provides corneal stromal stem cells and certain other stem cells and as well as exosome polynucleotides produced by such cells, and methods for making and using these cells and compositions. The invention is based upon the discovery that exosomes and their associate active components obtained from these cells comprise agents having the same capacity as corneal stromal stem cells to reduce scarring and prevent scar formation in patients having corneal damage.

IPC Classes  ?

  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 9/00 - Medicinal preparations characterised by special physical form

69.

AUTOMATED CARDIAC FUNCTION ASSESSMENT BY ECHOCARDIOGRAPHY

      
Application Number 16977418
Status Pending
Filing Date 2019-03-14
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Deo, Rahul C.
  • Zhang, Jeffrey

Abstract

A computer vision pipeline is provided for fully automated interpretation of cardiac function, using a combination of machine learning strategies to enable building a scalable analysis pipeline for echocardiogram interpretation. Videos from patients with heart failure can be analyzed and processed as follows: 1) preprocessing of echo studies; 2) convolutional neural networks (CNN) processing for view identification; 3) segmentation of chambers and delineation of cardiac boundaries using CNNs; 4); particle tracking to compute longitudinal strain; and 5) targeted disease detection.

IPC Classes  ?

  • A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
  • A61B 8/06 - Measuring blood flow
  • A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
  • G06T 7/00 - Image analysis
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G06N 3/08 - Learning methods

70.

BIOREACTIVE COMPOSITIONS AND METHODS OF USE THEREOF

      
Application Number 16977439
Status Pending
Filing Date 2019-03-08
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Wang, Lei
  • Wang, Nanxi

Abstract

Provided herein are, inter alia, non-toxic, bioreactive unnatural amino acids and methods of using same.

IPC Classes  ?

  • C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
  • C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
  • C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

71.

DOCKING SYSTEM TO STABILIZE EYEBALL DURING INTRAOCULAR SURGERY

      
Application Number 17021925
Status Pending
Filing Date 2020-09-15
First Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Gerber, Matthew
  • Lee, Yu-Hsiu
  • Tsao, Tsu-Chin
  • Rosen, Jacob
  • Hubschman, Jean-Pierre

Abstract

A docking system for intraocular surgery that is configured to simultaneously: (1) physically stabilize a position and an orientation of an eye during intraocular surgical procedures; (2) preserve an unobstructed path for optical instruments; (3) provide access to the eye that allows for tool movement; (4) maintain eyeball hydration and improve the scan quality of an imaging system, such as an OCT system or a surgical microscope and may maintain or control an intraocular pressure of the eye to a stable, desired level during surgical procedures.

IPC Classes  ?

  • A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
  • A61F 9/007 - Methods or devices for eye surgery
  • A61B 90/20 - Surgical microscopes characterised by non-optical aspects

72.

Novel Lanthanide Doped Cesium Barium Halide Scintillators

      
Application Number 17024590
Status Pending
Filing Date 2020-09-17
First Publication Date 2021-01-07
Owner The Regents of the University of California (USA)
Inventor
  • Borade, Ramesh B.
  • Bizarri, Gregory A.
  • Bourret-Courchesne, Edith D.
  • Derenzo, Stephen E.
  • Hanrahan, Stephen M.
  • Yan, Zewu
  • Chaudry, Anurag
  • Canning, Andrew

Abstract

The present invention provides for a composition comprising an inorganic scintillator comprising an optionally lanthanide-doped cesium barium halide, useful for detecting nuclear material.

IPC Classes  ?

  • G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal
  • C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals
  • G21K 4/00 - Conversion screens for the conversion of the spatial distribution of particles or ionising radiation into visible images, e.g. fluoroscopic screens

73.

Split Trans-Complementing Gene-Drive System for Suppressing Aedes Aegypti Mosquitos

      
Application Number 16325110
Status Pending
Filing Date 2017-08-17
First Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Bier, Ethan
  • Gantz, Valentino
  • James, Anthony A.

Abstract

Provided are systems, constructs, genetically modified organisms, and methods for greatly reducing or eliminating local populations of Aedes aegypti mosquitoes, and associated Dengue fever, yellow fever, Zika virus, and Chikungunya virus. Provided are genetically modified Aedes aegypti having a Cas9-mediated split gene-drive system for masculinizing the mosquito and ensuring that any female carries a sterile mutation. In addition, gRNAs direct Cas9 cleavage of insecticide-resistance loci, rendering female mosquitoes escaping the male converting gene drive sensitive to insecticides.

IPC Classes  ?

  • A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
  • C12N 9/22 - Ribonucleases

74.

MICROFLUIDIC-ENABLED MULTIWELL CELL CULTURE DEVICES AND SYSTEMS FOR PRECISION CULTURE, CONTROL AND MONITORING OF LIVING CELLS

      
Application Number 16614290
Status Pending
Filing Date 2018-05-15
First Publication Date 2021-01-07
Owner
  • Cairn Biosciences, Inc. (USA)
  • The Regents of the University of California (USA)
Inventor
  • Ludlam, Mary J. C.
  • Blanco, Austin
  • Wartmann, David
  • Mathies, Richard A.

Abstract

Devices, systems, methods, and techniques regarding a microfluidic-enabled multiwell device with closed-loop monitoring and control of various parameters of the microfluidic environment are provided. A microfluidic-enabled multiwell device may have a removable and disposable microfluidics module layer and a reusable sensor module layer. The sensor module layer may be configured to monitor and control parameters of the environment inside the microfluidics module layer, store data regarding the parameters, and wirelessly transmit the data. The device may be configured to individually address flow of fluid to any one of a plurality of wells, using one or more pneumatic micropumps. The device may be configured to automatically execute one or more live cell cultures, assays, and/or protocols. The device may be configured to be received in a docking station and/or portable manifold adapter, and to be fluidly, pneumatically, and/or electronically coupled to the station, adapter, or other laboratory equipment.

IPC Classes  ?

  • C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
  • C12M 1/32 - Inoculator or sampler multiple field or continuous type
  • C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

75.

ELECTROCHEMICAL CONVERSION

      
Application Number US2020026003
Publication Number 2021/002905
Status In Force
Filing Date 2020-03-31
Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Zhanaidarova, Almagul
  • Kubiak, Clifford, P.

Abstract

22 to CO. The application presents a class of electrodes, incorporating molecular catalysts in nanostructures, for robust and efficient electrochemical systems, specifically, selective and robust hybrid electrodes, by incorporating a rhenium (Re) catalyst into the structure of highly porous heterogeneous materials. These electrodes can be scaled up to desired manufacturing dimensions due to their robust nature and methods of preparation.

IPC Classes  ?

76.

QUADRATURE PHASE SHIFT KEYING QUADRATURE AMPLITUDE MODULATION TRANSMITTER

      
Application Number US2020038073
Publication Number 2021/003019
Status In Force
Filing Date 2020-06-17
Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Mohammadnezhad, Hossein
  • Wang, Huan
  • Heydari, Payam

Abstract

Aspects of quadrature phase shift keying for quadrature amplitude modulation are described. In some examples, quadrature phase shift keying signals are generated using quadrature phase shift keying modulators. The quadrature phase shift keying signals are combined in a combiner circuit to generate a quadrature amplitude modulation signal for wireless transmission.

IPC Classes  ?

  • H04L 27/00 - Modulated-carrier systems
  • H04L 27/32 - Carrier systems characterised by combinations of two or more of the types covered by groups , , , or
  • H04L 27/34 - Amplitude- and phase-modulated carrier systems, e.g. quadrature-amplitude modulated carrier systems
  • H04L 27/36 - Modulator circuits; Transmitter circuits

77.

IMMUNOTHERAPY TARGETING CELL SURFACE MARKER CD72 FOR THE TREATMENT OF B-CELL MALIGNANCIES

      
Application Number US2020040749
Publication Number 2021/003428
Status In Force
Filing Date 2020-07-02
Publication Date 2021-01-07
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Nix, Matthew
  • Wiita, Arun

Abstract

Provided herein are anti-CD72 nanobodies and methods of using such nanobodies for diagnostic and therapeutic purposes.

IPC Classes  ?

  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans

78.

Chemically modified surfaces with self-assembled aromatic functionalities

      
Application Number 15454878
Grant Number 10883000
Status In Force
Filing Date 2017-03-09
First Publication Date 2021-01-05
Grant Date 2021-01-05
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Yang, Jenny Y.
  • Lydon, Brian R.

Abstract

Materials and methods of modifying an electrode surface are described herein. Self-assembled monolayers (SAM) of polyaromatic molecules covalently attached and form a graphitic-like surface on the electrode surface. After covalent attachment of the polyaromatic monolayer to the surface, polyaromatic-functionalized molecular species is physisorbed onto the surface using the π-interactions. This concept can be applied to generate high performance electrode materials modified with molecular species. The electrode materials can be applied in photoelectrochemical cells, electrochemical cells, sensors, and electrochromic materials. This approach overcomes the major synthetic challenges to modifying surfaces with molecular species, in addition to protecting the surfaces from corrosion.

IPC Classes  ?

  • C09D 5/08 - Anti-corrosive paints
  • C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
  • G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
  • C23F 13/00 - Inhibiting corrosion of metals by anodic or cathodic protection

79.

METHOD AND APPARATUS FOR EFFICIENT COMMUNICATION PACKET GENERATION IN INTERNET OF THINGS (IOT)

      
Application Number 16914778
Status Pending
Filing Date 2020-06-29
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Guimaraes, Vinicius Galvao
  • Obraczka, Katia
  • Bauchspiess, Adolfo
  • De Moraes, Renato Mariz

Abstract

Techniques for efficient communication packet generation in internet of things (IOT) include presenting an application programming interface to each of a plurality of protocols in a plurality of different layers of a network communications protocol stack. A single packet buffer is configured in memory to hold headers for all of the plurality of protocols for a packet directed to a first destination node. Pointers are also stored in memory to tables maintained by the plurality of protocols. In response to receiving input at the application programming interface from a first protocol, at least one bit is updated in the single packet buffer based on the input and on data in a table maintained by a different second protocol of the plurality of protocols.

IPC Classes  ?

  • H04L 29/06 - Communication control; Communication processing characterised by a protocol
  • H04L 12/861 - Packet buffering or queuing arrangements; Queue scheduling
  • H04W 28/02 - Traffic management, e.g. flow control or congestion control

80.

VERSATILE, HIGH-YIELD PROTEIN PRODUCTION EX VIVO

      
Application Number 16914997
Status Pending
Filing Date 2020-06-29
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Tan, Cheemeng
  • Llano, Luis Eduardo Contreras
  • Meyer, Conary
  • Villarreal, Fernando

Abstract

A cell lysate or cell-free protein synthesis system comprising recombinant translational proteins and uses thereof are provided.

IPC Classes  ?

  • C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
  • C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
  • C12N 15/67 - General methods for enhancing the expression

81.

THRESHOLD-STIMULATED PLASMA KALLIKREIN ACTIVITY AS A BIOMARKER FOR DIAGNOSIS OF BRADYKININ-MEDIATED ANGIOEDEMA

      
Application Number 16971664
Status Pending
Filing Date 2019-02-22
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Zuraw, Bruce
  • Lara-Marquez, Maria Luz

Abstract

Provided is a diagnostic test for the positive identification of patients with bradykinin-mediated angioedema. The test is valuable for distinguishing bradykinin-mediated angioedema from non-bradykinin-mediated angioedema. The test allows clinicians to clearly separate patients with bradykinin-mediated from histamine-mediated angioedema. Results can be obtained in under an hour, allowing for the proper treatment of angioedema based on the underlying etiology.

IPC Classes  ?

  • C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

82.

Electrochemical Removal of Arsenic Using An Air Diffusion Cathode

      
Application Number 16976705
Status Pending
Filing Date 2019-03-04
First Publication Date 2020-12-31
Owner
  • The Regents of the University of California (USA)
  • Universiteit Utrecht Holding B.V. (Netherlands)
Inventor
  • Gadgil, Ashok
  • Bandaru, Siva Rama Satyam
  • Van Genuchten, Case

Abstract

The present invention provides methods for removing arsenic from an aqueous solution containing dissolved arsenic using a continuous-flow air-cathode iron electrocoagulation device and current densities of from at least 30 mA·cm−2 to about 250 mA·cm−2. The present invention also provides continuous-flow air-cathode iron electrocoagulation devices having barriers for reducing electrode fouling and maintaining faradaic efficiency for longer periods of time.

IPC Classes  ?

  • C02F 1/463 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrocoagulation
  • C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection

83.

MODULAR SYSTEM FOR GENE AND PROTEIN DELIVERY BASED ON AAV

      
Application Number 16976720
Status Pending
Filing Date 2019-02-28
First Publication Date 2020-12-31
Owner
  • University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
  • The Regents of the University of California (USA)
Inventor
  • Byrne, Leah
  • Ozturk, Bilge Esin
  • Day, Timothy

Abstract

In one embodiment, the invention provides an Adeno-Associated Virus (AAV) comprising an exterior surface, which surface comprises one or more peptide tags that form a bond with a binding-partner, wherein the AAV is a live virus. In another embodiment, the invention provides a conjugate comprising at least one such AAV and at least one polypeptide comprising a first domain which is the binding-partner for the tag and a second domain, which is a bioactive polypeptide. In another embodiment, the invention provides a conjugate comprising at least one such AAV (first AAV) and at least one second AAV, which second AAV comprises a second exterior surface, which second exterior surface comprises at least one binding-partner for the tag or for a third linker molecule, wherein the at least one first AAV and the at least one second AAV are bound.

IPC Classes  ?

  • C12N 15/86 - Viral vectors
  • C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

84.

REDUCTION OF MILK GLYCANS AND THEIR DEGRADATION PRODUCTS IN THE NEONATE GUT

      
Application Number 16996732
Status Pending
Filing Date 2020-08-18
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Mills, David A.
  • Frese, Steven A.

Abstract

Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.

IPC Classes  ?

  • A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
  • A01N 63/10 - Animals; Substances produced thereby or obtained therefrom
  • C12R 1/225 - Lactobacillus

85.

TUNABLE LINEAR FLUOROPOLYMERS

      
Application Number 16764680
Status Pending
Filing Date 2018-11-16
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Sletten, Ellen M.
  • Jaye, Joseph A.

Abstract

The present disclosure provides tunable fluoropolymers and methods for making them.

IPC Classes  ?

  • C08F 214/18 - Monomers containing fluorine
  • C08F 138/00 - Homopolymers of compounds having one or more carbon-to-carbon triple bonds
  • C08F 118/12 - Esters of monocarboxylic acids with unsaturated alcohols containing three or more carbon atoms
  • C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
  • C08F 8/26 - Removing halogen atoms or halogen-containing groups from the molecule

86.

ADDITIVE-FREE MANUFACTURING OF GEOMETRICALLY COMPLEX COMPONENTS FOR ELECTRICAL ENERGY STORAGE SYSTEMS

      
Application Number 16859857
Status Pending
Filing Date 2020-04-27
First Publication Date 2020-12-31
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • CALIFORNIA INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Schoenung, Julie M.
  • Acord, Katherine A.
  • Zheng, Baolong
  • Bertoli, Umberto Scipioni
  • Shapiro, Andrew A.
  • Chen, Qian Nataly
  • West, William C.

Abstract

In some embodiments, high-energy additive manufacturing (HE-AM) (e.g., directed energy deposition, powder injection, powder bed fusion, electron beam melting, solid-state, and ultrasonic) is used to overcome constraints of comparative EES fabrication techniques to produce chemical additive-free electrodes with complex, highly versatile designs for next generation EES. An exemplary rapid fabrication technique provides an approach for improving electrochemical performance while increasing efficiency and sustainability, reducing time to market, and lowering production costs. With this exemplary technique, which utilizes computer models for location specific layer-by-layer fabrication of three-dimensional parts (e.g., versatile design), a high degree of control over processing conditions may be achieved to enhance both the design and performance of EES systems.

IPC Classes  ?

  • H01M 4/04 - Processes of manufacture in general
  • H01M 10/058 - Construction or manufacture
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
  • H01M 10/04 - Construction or manufacture in general

87.

FUSION PROTEINS AND METHODS FOR SITE-DIRECTED GENOME EDITING

      
Application Number 16877020
Status Pending
Filing Date 2020-05-18
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Zheng, Yuxuan
  • Lorenzo, Claire
  • Beal, Peter
  • Fisher, Andrew
  • Monteleone, Leanna

Abstract

In some aspects, the present invention provides methods and compositions for modifying target sites within nucleic acid molecules. In some embodiments, the methods comprise using adenosine deaminases that act on RNA (ADARs), and variants thereof, to modify target sites within DNA-RNA hybrid molecules. In other aspects, ADAR2 variant polypeptides as well as fusion proteins comprising an ADAR catalytic domain and a hybrid nucleic acid binding domain are provided, as are methods for use thereof. Methods for preventing and treating genetic disorders are also provided herein.

IPC Classes  ?

  • C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
  • C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
  • C12N 15/62 - DNA sequences coding for fusion proteins

88.

PI3KGAMMA INHIBITORS

      
Application Number 16911894
Status Pending
Filing Date 2020-06-25
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Varner, Judith
  • Amaro, Rommie
  • Kaneda, Megan
  • Malmstrom, Robert
  • Feher, Victoria

Abstract

The present disclosure relates to PI3Kγ inhibitors and methods of their use.

IPC Classes  ?

  • A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
  • A61K 31/453 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
  • A61K 31/444 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/4196 - 1,2,4-Triazoles
  • A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems

89.

SYSTEMS AND METHODS FOR PRODUCING CARBON NANOSTRUCTURES AND ULTRATHIN ALIGNED CARBON WIRES WITH MULTILAYER TURBOSTRATIC GRAPHENE STRUCTURE

      
Application Number 16915339
Status Pending
Filing Date 2020-06-29
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Madou, Marc
  • Deng, Jufeng
  • Hwu, Alexander
  • Yan, Xingxu

Abstract

Systems and methods are provided for fabricating carbon nanostructures by low voltage near-field electromechanical spinning (LV-NFEMS). Processes described herein can produce ˜2-5 nm carbon nanowires with ultrahigh electrical conductivity using top-down and controlled reductive techniques from a polymer. Configurations are also provided to allow for deposition control and fiber elongation/alignment. One embodiment uses a low voltage near-field electromechanical spinning process to produce a polymer fiber from a polymer solution. Another embodiment of the method uses pyrolysis to convert the produced polymer fiber into a ˜2-5 nm carbon nanowire. System configurations provide advancements in polymer droplet control and control of a sustained jet of polymer solution with the use low voltages. Systems and processes described herein can include use of an array of polymer precursor nanofibers suspended onto a silicon substrate and converted to carbon nanowires. In another embodiment, ultra-thin carbon fibers can be integrated onto a carbon electrode scaffold.

IPC Classes  ?

  • D01D 5/00 - Formation of filaments, threads, or the like
  • D01F 9/32 - Apparatus therefor
  • B29C 48/05 - Filamentary, e.g. strands
  • B29C 48/14 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration

90.

SYSTEMS, CIRCUITS AND COMPUTER PROGRAM PRODUCTS PROVIDING A FRAMEWORK FOR SECURED COLLABORATIVE TRAINING USING HYPER-DIMENSIONAL VECTOR BASED DATA ENCODING/DECODING AND RELATED METHODS

      
Application Number 16915643
Status Pending
Filing Date 2020-06-29
First Publication Date 2020-12-31
Owner The Regents of the University of Californie (USA)
Inventor
  • Imani, Mohsen
  • Kim, Yeseong
  • Rosing, Tajana
  • Koushanfar, Farinaz
  • Riazi, Mohammad Sadegh

Abstract

A computing system can include a plurality of clients located outside a cloud-based computing environment, where each of the clients may be configured to encode respective original data with a respective unique secret key to generate data hypervectors that encode the original data. A collaborative machine learning system can operate in the cloud-based computing environment and can be operatively coupled to the plurality of clients, where the collaborative machine learning system can be configured to operate on the data hypervectors that encode the original data to train a machine learning model operated by the collaborative machine learning system or to generate an inference from the machine learning model.

IPC Classes  ?

91.

METHODS AND COMPOSITIONS RELATING TO EPOXIDE HYDROLASE GENES

      
Application Number 16976285
Status Pending
Filing Date 2019-03-01
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Lynch, Susan V.
  • Levan, Sophia Rose

Abstract

Provided herein are, inter alia, methods and kits for detecting epoxide hydrolase genes. In embodiments, methods and kits for detecting the risk of developing atopy or asthma are included. Also included are methods for preventing or treating atopy or asthma.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
  • C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
  • A61K 31/47 - Quinolines; Isoquinolines
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
  • A61K 31/59 - Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
  • A61K 35/741 - Probiotics
  • A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
  • A61K 35/60 - Fish, e.g. seahorses; Fish eggs
  • A61K 35/745 - Bifidobacteria
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
  • G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

92.

A HEPATOCYTE-MIMICKING ANTIDOTE FOR ALCOHOL INTOXICATION

      
Application Number 16980582
Status Pending
Filing Date 2019-03-29
First Publication Date 2020-12-31
Owner The Regents of the University of California (USA)
Inventor
  • Lu, Yunfeng
  • Ji, Cheng
  • Xu, Duo
  • Han, Hui

Abstract

Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. We disclose a hepatocyte-mimicking antidote for alcohol intoxication through the co-delivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Administered to alcohol-intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning.

IPC Classes  ?

  • A61K 38/44 - Oxidoreductases (1)
  • A61K 31/7084 - Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/50 - Microcapsules

93.

FLEXIBLE SPINAL CORD STIMULATORS FOR PAIN AND TRAUMA MANAGEMENT THROUGH NEUROMODULATION

      
Application Number 16981204
Status Pending
Filing Date 2019-03-15
First Publication Date 2020-12-31
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Gaonkar, Bilwaj
  • Moran, Steven L.
  • Hanna, Amir
  • Macyszyn, Luke
  • Iyer, Subramanian S.

Abstract

A spinal cord stimulator includes: (1) a flexible substrate; (2) a power source embedded in the flexible substrate; (3) a controller embedded in the flexible substrate and connected to the power source; and (4) an array of electrodes, including an array of stimulation electrodes, disposed over the flexible substrate and connected to the controller, wherein the controller is configured to direct the array of stimulation electrodes to deliver a stimulation pattern to a spinal cord of a patient.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/378 - Electrical supply

94.

ADDITIVE-FREE MANUFACTURING OF GEOMETRICALLY COMPLEX COMPONENTS FOR ELECTRICAL ENERGY STORAGE SYSTEMS

      
Application Number US2020029966
Publication Number 2020/263400
Status In Force
Filing Date 2020-04-24
Publication Date 2020-12-30
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • CALIFORNIA INSTITUTE OF TECHNOLOGY (USA)
Inventor
  • Schoenung, Julie M.
  • Acord, Katherine A.
  • Zheng, Baolong
  • Bertoli, Umberto Scipioni
  • Shapiro, Andrew A.
  • Chen, Qian Nataly
  • West, William C.

Abstract

In some embodiments, high-energy additive manufacturing (HE-AM) (e.g., directed energy deposition, powder injection, powder bed fusion, electron beam melting, solid-state, and ultrasonic) is used to overcome constraints of comparative EES fabrication techniques to produce chemical additive-free electrodes with complex, highly versatile designs for next generation EES. An exemplary rapid fabrication technique provides an approach for improving electrochemical performance while increasing efficiency and sustainability, reducing time to market, and lowering production costs. With this exemplary technique, which utilizes computer models for location specific layer-by-layer fabrication of three- dimensional parts (e.g., versatile design), a high degree of control over processing conditions may be achieved to enhance both the design and performance of EES systems.

IPC Classes  ?

  • B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
  • C23C 24/08 - Coating starting from inorganic powder by application of heat or pressure and heat
  • C23C 26/00 - Coating not provided for in groups
  • C23C 28/02 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and only coatings of metallic material

95.

INTEGRATED SYSTEM FOR MECHANICAL PROCESSING OF LIPOASPIRATE

      
Application Number US2020039187
Publication Number 2020/263858
Status In Force
Filing Date 2020-06-23
Publication Date 2020-12-30
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Haun, Jered
  • Lombardo, Jeremy A.

Abstract

An integrated lipoaspirate processing system is disclosed for mechanically processing adipose tissue into a therapeutic material that, in some embodiments, may be directly injected into a subject. The system includes an emulsification device that is used to emulsify the lipoaspirate sample. The emulsified lipoaspirate is then filtered by a microfluidic filtration device. The filtrate of the microfluidic filtration device is then processed in a microfluidic dissociation device. The integrated platform or system helps standardize hydrodynamic processing of lipoaspirate by producing predictable and consistent shear forces and enabling automation in clinical settings. Progressive processing through multiple devices in series enables optimal recovery of regenerative cells while preventing clogging.

IPC Classes  ?

  • A61K 31/00 - Medicinal preparations containing organic active ingredients
  • A61K 35/35 - Fat tissue; Adipocytes; Stromal cells; Connective tissues 
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

96.

METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE

      
Application Number US2020039194
Publication Number 2020/263862
Status In Force
Filing Date 2020-06-23
Publication Date 2020-12-30
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Zou, Yimin
  • Feng, Bo
  • Tian, Runyi
  • Freitas, Andiara

Abstract

Provided herein are methods and agents for modulating the signaling pathway and components thereof that are responsible for assembly and disassembly of synapses in neurons, including amyloid beta (Aβ) mediated synaptotoxicity and synapse loss. Also provided herein are methods for screening and identifying candidate agents capable of modulating synapse formation and (Aβ) mediated synaptotoxicity.

IPC Classes  ?

  • A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

97.

BCL11B OVEREXPRESSION TO ENHANCE HUMAN THYMOPOIESIS AND T CELL FUNCTION

      
Application Number US2020039414
Publication Number 2020/264019
Status In Force
Filing Date 2020-06-24
Publication Date 2020-12-30
Owner
  • CHILDREN'S HOSPITAL LOS ANGELES (USA)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Parekh, Chintan
  • Crooks, Gay
  • Seet, Christopher
  • Montel-Hagen, Amelie

Abstract

BCL11BBCL11BBCL11B expression in the HSPCs, pluripotent stem cells, or mature T cells increases production and/or proliferation of T cells from the HSPCs and/or the pluripotent stem cells, and/or increases proliferation of the T cells.

IPC Classes  ?

98.

PI3KGAMMA INHIBITORS

      
Application Number US2020039563
Publication Number 2020/264120
Status In Force
Filing Date 2020-06-25
Publication Date 2020-12-30
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Varner, Judith
  • Amaro, Rommie
  • Kaneda, Megan
  • Malmstrom, Robert
  • Feher, Victoria

Abstract

The present disclosure relates to ΡΙ3Κγ inhibitors and methods of their use.

IPC Classes  ?

  • A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
  • A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
  • A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

99.

REDUCED ORDER MODEL FOR COMPUTING BLOOD FLOW DYNAMICS

      
Application Number US2020039765
Publication Number 2020/264259
Status In Force
Filing Date 2020-06-26
Publication Date 2020-12-30
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Mirramezani, Seyed, Mehran
  • Shadden, Shawn

Abstract

A computer- implemented method can include generating centerlines of a patient's cardiovascular network, determining geometric features of the cardiovascular network based on the centerlines and a three-dimensional (3D) computer model of the cardiovascular network, constructing a lumped parameter network (LPN) of resistors corresponding to the cardiovascular network, and solving a system of equations corresponding to flow and pressure for the LPN model.

IPC Classes  ?

  • A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure

100.

THZ IMPULSE AND FREQUENCY COMB GENERATION USING REVERSE RECOVERY OF PIN DIODE

      
Application Number US2020039800
Publication Number 2020/264279
Status In Force
Filing Date 2020-06-26
Publication Date 2020-12-30
Owner THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventor
  • Babakhani, Aydin
  • Razavian, Seyedmohammadreza

Abstract

Many embodiments provide a frequency comb receiver that includes a PIN diode, a THz pulse generator block that generates THz tones (LO) for coherent frequency comb detection, an on-chip antenna for broadband detection and a driver stage switched by a series of buffers, where a repetition rate of the LO tones are tunable over a range and determines a spacing between two adjacent tones in the corresponding frequency comb.

IPC Classes  ?

  • H01Q 3/26 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture
  • H01Q 3/38 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means with variable phase-shifters the phase-shifters being digital
  • H01Q 13/08 - Radiating ends of two-conductor microwave transmission lines, e.g. of coaxial lines, of microstrip lines
  • H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
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