Abstract

The present disclosure relates to IgA antibodies and antigen binding fragments thereof and to cocktails of antibodies and antigen binding fragments that neutralize virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The present disclosure also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/18 - Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus

Abstract

The present disclosure is directed to monoclonal antibodies, or antigen-binding fragments thereof, that bind to coronavirus spike proteins, including the spike protein of SARS-CoV-2. These antibodies demonstrate high affinity binding to epitopes on the coronavirus spike protein and/or broad cross-reactivity to the spike protein of various coronaviruses. Compositions comprising the anti-coronavirus antibodies, nucleic acids encoding for the antibodies, recombinant expression vectors, and host cells are also disclosed. The present disclosure is also directed to methods of diagnosing, preventing or treating coronavirus infections, including infections or disease caused by SARS-CoV-2.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/42 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
• A61P 31/14 - Antivirals for RNA viruses
• C07K 16/46 - Hybrid immunoglobulins
• C12N 15/13 - Immunoglobulins

Abstract

A thermogenic emergency airway management device configured to prevent or treat hypothermia in a patient. The device may be configured to receive ambient air and modify one or more properties of the ambient air to output air at a temperature and/or humidity associated with the prevention and/or treatment of hypothermia. In an embodiment, the device may receive input via a user interface to determine a temperature and/or humidity associated with the air to be output to the patient. In an embodiment, the input may additionally include an amount of air to be output to be the patient. In such an embodiment, the device may be configured to cause the amount of air to be output to the patient to prevent and/or treat hypothermia.

IPC Classes  ?

• A61M 16/10 - Preparation of respiratory gases or vapours
• A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
• A61M 16/20 - Valves specially adapted to medical respiratory devices

Abstract

Provided are cathepsin inhibitor compounds and pharmaceutically acceptable salts thereof, and combinations thereof, for use in the treatment or prophylaxis of viral disease in an animal.

IPC Classes  ?

• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present disclosure relates to the field of vaccines and binding molecules, as well as preparations and methods of their use in the treatment and/or prevention of disease. Described are vaccines and binding molecules, compositions containing the same, and uses thereof for treating or preventing coronavirus infections, in particular, ?-coronaviruses such as SARS- CoV-2, the causative agent of COVID-19, as well as SARS-CoV-1 and other coronaviruses.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus

Abstract

Described is the preparation of novel fentanyl haptens of Formula (1) through (6) and their use in the preparation of effective fentanyl vaccines.

IPC Classes  ?

• C07D 211/06 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
• A61K 31/4468 - Non-condensed piperidines, e.g. piperocaine having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
• A61P 25/36 - Opioid-abuse
• C07D 211/58 - Nitrogen atoms attached in position 4

Abstract

A therapeutic hemoglobin-based oxygen carrier solution is formed by directly combining at least one of freeze-dried platelets and freeze-drug plasma with a hemoglobin-based oxygen carrier. The therapeutic hemoglobin-based oxygen carrier solution can be employed to treat bleeding or anemia and simultaneously increase systemic convective oxygen delivery in a subject suffering low circulatory oxygen transport or bleeding.

IPC Classes  ?

• A61K 38/42 - Haemoglobins; Myoglobins
• A61K 35/19 - Platelets; Megacaryocytes
• A61K 35/16 - Blood plasma; Blood serum
• A61K 47/02 - Inorganic compounds
• A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
• A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• A61P 7/04 - Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• A61P 7/06 - Antianaemics
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/42 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
• A61P 31/14 - Antivirals for RNA viruses
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
• C07K 16/46 - Hybrid immunoglobulins
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
• C12N 15/13 - Immunoglobulins
• C12P 21/08 - Monoclonal antibodies
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C07K 14/18 - Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus

Abstract

Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g. tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components.

IPC Classes  ?

• C22C 21/00 - Alloys based on aluminium
• E21B 23/06 - Apparatus for displacing, setting, locking, releasing or removing tools, packers or the like in boreholes or wells for setting packers
• E21B 33/12 - Packers; Plugs

Abstract

Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

A method of creating a fragmentation pattern on a warhead comprising ablating material from the interior surface of the warhead according to a pre-defined fragmentation pattern. The pre-defined fragmentation pattern may be effected electronically or with a mask. The ablation may be effected by applying an etchant to the warhead interior surface material.

IPC Classes  ?

• F42B 12/24 - Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect of high-explosive type with fragmentation-hull construction with grooves, recesses or other wall weakenings
• F42B 12/32 - Projectiles, missiles or mines characterised by the warhead, the intended effect, or the material characterised by the warhead or the intended effect of high-explosive type with fragmentation-hull construction the hull or case comprising a plurality of discrete bodies, e.g. steel balls, embedded therein
• F42B 33/00 - Manufacture of ammunition; Dismantling of ammunition; Apparatus therefor

Abstract

An antenna system may include a first antenna, and a second antenna opposite the first antenna, wherein the first antenna and the second antenna are configured to provide omnidirectional coverage

IPC Classes  ?

• H01Q 21/29 - Combinations of different interacting antenna units for giving a desired directional characteristic
• B64G 1/66 - Arrangements or adaptations of apparatus or instruments, not otherwise provided for
• H01Q 1/44 - ANTENNAS, i.e. RADIO AERIALS - Details of, or arrangements associated with, antennas using equipment having another main function to serve additionally as an antenna
• H01Q 21/22 - Antenna units of the array energised non-uniformly in amplitude or phase, e.g. tapered array or binomial array

Abstract

Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects.

IPC Classes  ?

• A61K 31/47 - Quinolines; Isoquinolines
• A61P 33/06 - Antimalarials

Abstract

Cold spray devices and systems are disclosed. They include a flowpath having an inlet adapted for receiving communication with two or more inputs and an outlet adapted to discharge the two or more inputs. A discharge nozzle may be included in the flowpath of the outlet and a confluence may be included in the flowpath at the inlet for combining the two or more inputs. A nozzle body houses the discharge nozzle separate and downstream from the confluence of the two inputs.

IPC Classes  ?

• B05B 7/14 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas designed for spraying particulate materials
• B05D 1/12 - Applying particulate materials

Abstract

ABSTRACT A pre-fabricated tourniquet that is easy to apply, that ensures consistent and even circumferential pressure, that is light weight, that provides standard life saving operation, and that can be utilized in any setting or situation, and related methods are provided. Mechanically constricting tourniquet apparatus and related methods are provided that are comprised of a tourniquet body, a carriage, a torsion bar, a receiver and a slider. The tourniquet is long enough to encircle a human limb, for example, an arm or leg. Date recue/Date received 2023-09-27

IPC Classes  ?

• A61B 17/132 - Tourniquets
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets

Abstract

A pre-fabricated tourniquet that is easy to apply, that ensures consistent and even circumferential pressure, that is light weight, that provides standard life saving operation, and that can be utilized in any setting or situation, and related methods are provided. Mechanically constricting tourniquet apparatus and related methods are provided that are comprised of a tourniquet body, a carriage, a torsion bar, a receiver and a slider. The tourniquet is long enough to encircle a human limb, for example, an arm or leg.

IPC Classes  ?

• A61B 17/132 - Tourniquets

Abstract

A method and a system of estimating core temperatures of battery cells in a battery pack can include several steps. In one step, a surface temperature of one or more battery cell(s) is received, a current of the one or more battery cell(s) is received, an inlet temperature of coolant provided to the battery pack is received, and a flow rate or velocity of the coolant is received. In another step, estimations are made including those of a cell-lumped internal electrical resistance of the battery cell(s), a cell-lumped conduction resistance between a core and a surface of the battery cell(s), and a cell- lumped convection resistance between the surface and the coolant. In yet another step, an estimation is made of a core temperature of the battery cell(s) based upon the received and estimated values of previous steps.

IPC Classes  ?

• H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte

Abstract

A cementitious armor panel assembly including cementitious armor panel with ballistic and blast resistant properties attached to a frame structure to produce a protective structure. The cementitious armor panels have a continuous phase resulting from the curing of an aqueous mixture of an inorganic cement binder, an inorganic mineral filler having a particle size of about 150-450 microns, a pozzolanic mineral filler, a polycarboxylate based super- plasticizer self-leveling agent, and water. The mixture may also contain alkanolamine, and acid or acid salt. Prior to curing, the continuous phase is reinforced with fiber uniformly distributed in the continuous phase before it is cured to form the panel. The panel may be reinforced with a skin attached to at least one surface of the panel.

IPC Classes  ?

• F41H 5/04 - Plate construction composed of more than one layer
• C04B 28/28 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing organic polyacids, e.g. polycarboxylate cements
• F41H 5/02 - Plate construction

Abstract

A cementitious panel with ballistic and blast resistant properties having a core layer of ultra-high compressive strength composite and at least one skin layer. The panels can also be used in walls, ceiling and flooring panels which require high compressive strength for resistance to earthquakes and surfaces resistant to surface abuse such as in prison and other institutions. The panel core layer has a continuous cementitious phase resulting from the curing of an aqueous mixture, in the absence of silica flour, of inorganic cement binder, inorganic mineral filler having a particle size of about 150-450 microns, a pozzolanic mineral filler, polycarboxylate based superplasticizer, alkanolamine and acid or alkali metal acid salt; and water. The mixture may be uniformly reinforced with fiber added before curing. The cementitious core layer is then reinforced with the skin, such as fiber reinforced polymer, attached to at least one panel surface.

IPC Classes  ?

• F41H 5/04 - Plate construction composed of more than one layer
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 13/12 - Layered products essentially comprising a water-setting substance, e.g. concrete, plaster, asbestos cement, or like builders' material comprising such substances as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• B32B 13/14 - Layered products essentially comprising a water-setting substance, e.g. concrete, plaster, asbestos cement, or like builders' material next to a fibrous or filamentary layer

Abstract

A self-leveling cementitious mixture with excellent flow properties and which hardens with a controlled rate of strength development to an ultra-high compressive strength composite composition for use in making articles such as cementitious armor panel with ballistic and blast resistant properties including: a continuous phase resulting from the curing of an aqueous mixture, in the absence of silica flour, of inorganic cement binder, inorganic mineral filler having a particle size of about 150-450 microns, pozzolanic mineral filler, polycarboxylate based self-leveling agent and water. The cementitious mixture may include alkanolamine, such as thethanolamine, and acid or acid salt, such as tartaric acid. The cementitious composition may be reinforced with reinforcing fibers, e.g. glass fibers, in an amount of about 0.5 - 6.0 % by volume of the overall cementitious composition. The fibers are uniformly dispersed in the cementitious composition before it is cured to form a final cementitious armor panel.

IPC Classes  ?

• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
• C04B 14/02 - Granular materials
• C04B 14/38 - Fibrous materials; Whiskers

Abstract

A one part, solids containing decontamination blend composition comprises a solid acetyl donor coated with a compound that protects it from hydrolysis, a peroxygen source, optionally a catalyst, optionally a surfactant, and optionally a buffer. The decontamination blend composition is generally in a dry powder, particle, etc form or in a tablet, pill, etc form and is complete in and of itself in that no additional compounds are required prior to use and is readily distributed as a one package system. Upon the addition of water, a peroxygen compound such as hydrogen peroxide is formed, and peracetic acid is generated under alkaline conditions. The decontamination blend composition is particularly suitable for oxidizing various chemical and biological compounds thereby eradicating the same in situ as on surfaces, clothes, articles, and the like. Representative contaminants include mustard gas, nerve gas, bacterial toxins, anthrax, bird flu, and the like.

IPC Classes  ?

• A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• A62D 3/30 - Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances by reacting with chemical agents
• A01N 37/16 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group ; Thio-analogues thereof
• A01P 1/00 - Disinfectants; Antimicrobial compounds or mixtures thereof
• C11D 3/20 - Organic compounds containing oxygen

Abstract

A system for simulating one or more hemorrhages in order to provide a more dynamic and realistic hemorrhage simulation in order to train medical personnel and other critical care givers, such as first responders, medics, and emergency medical technicians (EMTs) on treating hemorrhages. The system includes a reservoir, a flow controller, and at least one conduit connected to at least one simulated wound site wherein the system supplies fluid to the simulated wound site in order to simulate a hemorrhage. The system may further include a plurality of wound sites that have their respective fluid flows controlled by the fluid flow controller. In at least one embodiment, the reservoir and the flow controller are housed within a bag. In at least one embodiment, the system further includes an audio system for providing audio cues to the simulation participants to enhance the realism of the simulation.

IPC Classes  ?

• G09B 23/30 - Anatomical models

Abstract

The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the AUG start site region of VP35, as exemplified by antisense compounds SEQ ID NO: 21- 26, ii) the AUG start site region of VP24, as exemplified by antisense compound SEQ ID NO:34, iii) the region 85 to 65 base pairs upstream of the AUG start site of VP24, as exemplified by SEQ ID NO:39, iv) the AUG start site region of polymerase L, as exemplified by antisense compound SEQ ID NO: 17, and v) combinations of (i), (ii), (iii), and/or (iv).

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

Hydrogen peroxide is vaporized (20) and mixed (30) with ammonia gas in a ratio between 1:1 and 1:0.0001. The peroxide and ammonia vapor mixture are conveyed to a treatment area (10) to neutralize V-type, H-type, or G-type chemical agents, pathogens, biotoxins, spores, prions, and the lip-,e. The ammonia provides the primary deactivating agent for G-type agents with the peroxide acting as an accelerator. The peroxide acts as the primary agent for deactivating V-type and H-type agents, pathogens, biotoxins, spores, and prions. The ammonia acts as an accelerator in at least some of these peroxide deactivation reactions.

IPC Classes  ?

• A62D 3/30 - Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances by reacting with chemical agents

Abstract

ABSTRACT A chirp transform correlator in which asynchronous operation is made possible by the use of a pair of paralleled signal process- ing channels to which the unknown signal to be correlated is applied. The two channels include sweeping local oscillators which are interlaced in timing so that any arbitrarily timed unknown input signal will be fully transformed by one or the other of said channels.

IPC Classes  ?

• G06G 7/19 - Arrangements for performing computing operations, e.g. amplifiers specially adapted therefor for analysis or synthesis of functions using orthogonal functions
• G01S 13/04 - Systems determining presence of a target

Abstract

ABSTRACT Doppler radar sets of the type including circuitry for determining and displaying sense of target motion along the radar beam. The Doppler phase shifters in the I and Q channels of pulse radars of this type are designed to operate at frequencies much higher than the Doppler baseband frequencies by selecting one of the Doppler sidebands of the radar's pulse repetition frequency, or one of the sidebands of a harmonic of such pulse repetition frequency, for application to said Doppler phase shifters. The higher operating frequency simplifies the design and construction of the Doppler phase shifters.

IPC Classes  ?

• G01S 13/62 - Sense-of-movement determination

Abstract

Abstract of the Disclosure The power supply potential applied to the final stage of an RF amplifier is modulated by means of an adaptive power supply. The power supply potential applied to the final RF amplifier is controlled by a first control loop in accordance with an error signal derived from a comparison of a signal cor- responding to the weighted sum of the magnitude of the supply voltage applied and the current drawn by the final amplifier and the amplitude of the modulating signal. Additionally, an automatic level control circuit controls the level of the RF output signal in a second control loop in accordance with a comparison between the magnitude of the RF output of the amplifier and the amplitude of the modulating signal.

IPC Classes  ?

• H03G 3/20 - Automatic control
• H03C 1/00 - Amplitude modulation

Abstract

ABSTRACT A Y-junction dielectric waveguide circulator is provided with a dielectric support plate. At the vertex of adjacent dielectric waveguides are positioned metal tuning legs. These tuning legs are spaced from the waveguides and extend higher than them. Preferably the tuning legs are made integral with a cap positioned above the circulator junction. This cap also serves as a holder for the upper biasing magnet. The lower magnet is centered under the junction and bonded to the bottom of the support plate.

IPC Classes  ?

• H01P 1/383 - Junction circulators, e.g. Y-circulators

Abstract

ABSTRACT A dielectric waveguide of rectangular cross-section has periodically spaced, transverse slots in its upper surface. When traveling waves of varying millimeter wavelength frequencies are applied to the waveguide, the slots perturb the waves resulting in radiation having a main lobe that scans as the frequency changes. The antenna is made rigid by the use of a dielectric support.

IPC Classes  ?

• H01Q 3/22 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the orientation in accordance with variation of frequency of radiated wave
• H01Q 13/28 - Non-resonant leaky-waveguide or transmission-line antennas; Equivalent structures causing radiation along the transmission path of a guided wave comprising elements constituting electric discontinuities and spaced in direction of wave propagation, e.g. dielectric elements or conductive elements forming artificial dielectric

Abstract

Abstract of the Disclosure A shaped charge warhead comprises a fragmenting wall defining a space which contains a shaped charge liner that is conical in shape having a large diameter base. The space between the liner and wall is filled with high explosive with a portion of the space adjacent the liner base being disposed by a support ring which interconnects the liner base with the wall. The reduc- tion of explosive near the line of base and the provision of the supporting ring improves the velocity configuratlon of a jet formed by the exploding warhead in that the velocity of the jet tail is reduced with respect to the velocity of the jet tip. The jet thus formed has increased an attrition capacity for antimaterial purposes.

IPC Classes  ?

• F42D 3/00 - Particular applications of blasting techniques