Abstract

Disclosed is an expression vector comprising a polynucleotide encoding for a glutamine synthetase with reduced activity compared to a wild type glutamine synthetase. Also disclosed are host cells, methods for preparing stable cell line, methods of producing polypeptide of interest, and kits thereof.

IPC Classes  ?

• C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Disclosed herein are methods and treatments for cartilage degradation, wherein the method comprises administration of a therapeutic agent which inhibits the Ga1N Ac-T activation (GALA) pathway.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.

IPC Classes  ?

• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

The present invention relates to an electrolyte comprising lithium difluoro(oxalate)borate (LiDFOB) and a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M, a rechargeable battery comprising the electrolyte as described herein, a cathode layer, an anode layer and a separator, and a method of preparing the electrolyte as described herein, comprising the step of dissolving LiDFOB in a carbonate solvent, wherein LiDFOB is present at a concentration in the range of 1.5 M to 3 M.

IPC Classes  ?

• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene. The disclosure concerns phosphorus compounds of formula (I), (II) and (III) and methods of synthesising these compounds. The phosphorus compound can be a cyclic phosphorus compound. The method comprises reacting a compound having two Michael acceptor groups with a hypophosphite ester, acid, salt or solvate thereof and an optional organosilicon compound. The diene can be a cyclodiene.

IPC Classes  ?

• C07F 9/6568 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System

Abstract

There is provided a pressure sensing device and related methods, the pressure sensing device comprising, a plurality of chambers for storing one or more visual indicators, wherein the plurality of chambers are configured to release the one or more visual indicators when a pressure exerted on the plurality of chambers exceeds one or more pressure thresholds. The plurality of chambers can be microchambers. The device may be used in conjunction with a bandaging system to indicate the pressure applied onto a site of treatment.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61F 13/08 - Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings for contracting aneurisms

Abstract

In some aspects, a set of input elements is obtained, at a rectified linear unit-activated neuron of a neural network based, on input data at the neuron. A first group and a second group of input elements are generated based on the set of input elements. The first group and the second group of input elements are associated with first weight elements and second weight elements, respectively. A first value is generated based on the first group of input elements and the first weight elements. A second value is generated based on the second group of input elements and the second weight elements. A third value and a fourth value are respectively generated based on a first operation and a second operation on the first value and the second value. An output of the neuron is generated based on the third value and the fourth value.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

There is provided a method of privacy-preserving logistic regression training based on homomorphically encrypted ciphertexts. The method includes: obtaining a first packed ciphertext comprising at least a portion of a first training data sample packed into a first vector of slots thereof for training a privacy-preserving logistic regression model; obtaining a second packed ciphertext comprising a plurality of weights of the privacy-preserving logistic regression model packed into a first vector of slots thereof; determining at least a first output probability of the privacy-preserving logistic regression model based on the first packed ciphertext and the second packed ciphertext; and updating the plurality of weights based on the first output probability. There is also provided a corresponding system for privacy-preserving logistic regression training based on homomorphically encrypted data.

IPC Classes  ?

• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
• H04L 9/00 - Arrangements for secret or secure communications; Network security protocols

Abstract

There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.

IPC Classes  ?

• A01N 59/16 - Heavy metals; Compounds thereof
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 7/62 - Additives non-macromolecular inorganic modified by treatment with other compounds
• A01N 25/12 - Powders or granules
• A61K 33/06 - Aluminium, calcium or magnesium; Compounds thereof
• A61K 33/32 - Manganese; Compounds thereof
• A61K 33/30 - Zinc; Compounds thereof
• A61K 33/26 - Iron; Compounds thereof
• A61K 9/50 - Microcapsules
• A01P 1/00 - Disinfectants; Antimicrobial compounds or mixtures thereof

Abstract

Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 35/00 - Antineoplastic agents
• C07K 16/46 - Hybrid immunoglobulins

Abstract

We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules: amplifying the barcode-tagged molecules; fragmenting the amplified barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6869 - Methods for sequencing

Abstract

A polymer particle production method includes: providing (12) one or more vinyl monomers; performing (14) free radical ring-opening polymerization (rROP) of cyclic ketene acetal (CKA) with the one or more vinyl monomers in a first organic solvent with a radical source to obtain a rROP reaction mixture; and emulsifying (16) the rROP reaction mixture in a second organic solvent to produce a plurality of polymer particles.

IPC Classes  ?

• C08F 222/10 - Esters
• C08F 222/26 - Esters of unsaturated alcohols
• C08F 2/06 - Organic solvent

Abstract

A titanium-tantalum alloy having a titanium wt % ranging from 10% to 70% and wherein the titanium has a body centered cubic structure. A method of forming a titanium-tantalum alloy, the method comprising the steps of: (a) slicing a 3D CAD model of a part to be formed into a plurality of 2D image layers; (b) preparing a homogenous powder mixture of titanium powder and tantalum powder; (c) dispensing a layer of the powder mixture onto a processing bed; (d) performing powder bed fusion of the layer of the powder mixture according to one of the 2D image layers in one of: a vacuum environment and an inert gas environment; and performing steps (c) and (d) for each of the plurality of 2D image layers in succession.

IPC Classes  ?

• C22C 14/00 - Alloys based on titanium
• B33Y 10/00 - Processes of additive manufacturing
• C22C 1/04 - Making non-ferrous alloys by powder metallurgy
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]

Abstract

There is provided a device for processing homomorphically encrypted data. The device includes: inter-line butterfly array blocks, each inter-line butterfly array block including inter-line modulus butterfly units, each inter-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same row of a matrix of input data points; intra-line butterfly array blocks, each intra-line butterfly array block including intra-line modulus butterfly units, each intra-line modulus butterfly unit being configured to perform a modulus butterfly operation based on a computation pair of data points received corresponding to a pair of input data points at a same column of the matrix of input data points; and a clock counter communicatively coupled to each inter-line butterfly array block and each intra-line butterfly array block, and configured to output a counter signal for controlling each inter-line butterfly array block and each intra-line butterfly array block to operate with single cycle initiation interval. The matrix of input data points includes columns of input data points, whereby parallel input data points derived from the homomorphically encrypted data are arranged into the columns of input data points. Furthermore, the inter-line butterfly array blocks and the intra-line butterfly array blocks are arranged in series to form a pipeline for processing the matrix of input data points.

IPC Classes  ?

• H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline, look ahead
• G06F 7/72 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radix; Computing devices using combinations of denominational and non-denominational quantity representations using residue arithmetic

Abstract

Various embodiments may relate to a piezoelectric device. The piezoelectric device may include a substrate, and a layered stacked arrangement anchored to the substrate. The layered stacked arrangement may include a piezoelectric layer. The stacked arrangement may also include a first electrode on a first side of the piezoelectric layer. The stacked arrangement may further include a second electrode on a second side of the piezoelectric layer opposite the first side. The piezoelectric layer may include a first region including one or more dipole domains of a first type, and one or more dipole domains of a second type. The first electrode may be at least partially in contact with the first region and at least partially in contact with the second region.

IPC Classes  ?

• H10N 30/20 - Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators
• H10N 30/853 - Ceramic compositions
• H10N 30/076 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by vapour phase deposition

Abstract

The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses

Abstract

The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61P 35/00 - Antineoplastic agents

Abstract

There is provided a device for vascularising a cell aggregate, the device comprising: a matrix region configured to contain a gel-like matrix and cells that form a vasculature network within th ematrix region. The matrix region having at least one opening for positioning the cell aggregate therein based on a desired three-dimensional spatial location; and one or more fluidic regions configured to contain a supporting fluid that is capable of supporting vascularisation of the cell aggregate, the one or more fluidic regions being in fluid communication with the matrix region, wherein a flow passage from the one or more fluidic regions to a gel-like matrix disposed in the matrix region is configured to allow three-dimensional vascularisation around the cell aggregate and perfusion of the vasculature once formed. There is also provided a chip comprising a plurality of the device as disclosed herein and a method for vascularising a cell aggregate.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

Various embodiments may relate to an acoustic resonator. The acoustic resonator may include a piezoelectric layer. The acoustic resonator may also include a first electrode in contact with a first surface of the piezoelectric layer. The acoustic resonator may further include a plurality of dielectric structures in contact with the first surface of the piezoelectric layer. The acoustic resonator may additionally include a second electrode in contact with a second surface of the piezoelectric layer opposite the first surface. The first electrode may include a plurality of electrode structures. A dielectric structure of the plurality of dielectric structures may be in contact with a pair of neighboring electrode structures of the plurality of electrode structures.

IPC Classes  ?

• H10N 30/067 - Forming single-layered electrodes of multilayered piezoelectric or electrostrictive parts
• H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals
• H03H 9/17 - Constructional features of resonators consisting of piezoelectric or electrostrictive material having a single resonator
• H10N 30/07 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base
• H03H 3/02 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of piezoelectric or electrostrictive resonators or networks

Abstract

Disclosed is an expression system for an antigen binding molecule and the uses thereof.

IPC Classes  ?

• C07K 16/46 - Hybrid immunoglobulins
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• C07K 14/71 - Receptors; Cell surface antigens; Cell surface determinants for growth regulators
• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants

Abstract

This document describes a spatial light modulator that comprises a pixel array having a plurality of pixels whereby each pixel in this array is communicatively coupled to a digital pixel circuit which are in turn all coupled to a bit-plane control circuit. The bit-plane control circuit is configured to generate, using a Pulse Code Modulation (PCM) algorithm, bit-plane signals that are used to control the sample and hold functions performed by each of the digital pixel circuits so that the pixel array may carry out its scanning function accurately and in a power efficient manner.

IPC Classes  ?

• G11C 11/418 - Address circuits
• G02F 1/133 - Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
• G02F 1/1343 - Electrodes
• G02F 1/1368 - Active matrix addressed cells in which the switching element is a three-electrode device
• G09G 3/36 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix by control of light from an independent source using liquid crystals

Abstract

There is provided a bioactive polyethylene copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a polyethylene macromolecule, a material comprising said bioactive polyethylene copolymer, a method of preparing said bioactive polyethylene copolymer and a method of preparing said polyethylene macromolecule.

IPC Classes  ?

• C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom

Abstract

A gripping device comprising: a base; at least one pair of extendable linkages connected at a proximal end to the base; each extendable linkage having a gripping finger extending from a distal end of the extendable linkage; wherein the extendable linkages are arranged to extend or retract from the base so as to increase a radial distance between the gripping fingers.

IPC Classes  ?

• B25J 15/12 - Gripping heads having finger members with flexible finger members
• B25J 15/10 - Gripping heads having finger members with three or more finger members
• B25J 15/06 - Gripping heads with vacuum or magnetic holding means

Abstract

There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule. There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.

IPC Classes  ?

• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring

Abstract

The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

IPC Classes  ?

• C07D 491/08 - Bridged systems
• C07D 215/233 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 451/06 - Oxygen atoms
• C07D 451/14 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Abstract

Disclosed is a system for sensor-based training intervention. The system includes one or more electroencephalogram (EEG) sensors for retrieving brain signals of a subject, one or more sensors for retrieving eye tracking data of one or both eyes of the subject, and one or more processors. The one or more processors are configured to model a joint state space of the brain signals and eye tacking data by combining the brain signals and eye tracking data into combined data using sequential Bayesian fusion, and measure a visuospatial attention indicator from combined data.

IPC Classes  ?

• A61B 5/16 - Devices for psychotechnics; Testing reaction times
• A61B 5/378 - Visual stimuli

Abstract

The invention relates generally to the field of molecular biology and microbiology. Provided herein is an expression construct encoding a fusion protein. In one embodiment, there is provided an expression construct encoding a fusion protein, the expression construct comprising a nucleic acid encoding a first polypeptide for expression and a second polypeptide derived from the cell wall targeting region of a Lactobacillus plantarum Lys2 autolysin, wherein the first and second polypeptides are joined to form a fusion protein. In a specific embodiment, the second polypeptide comprises the CAD4a domain, which is a truncated domain containing only R1-R3 of the five-repeat SH3_5 domain of the Lys2 autolysin. Provided herein is also a fusion protein and the use of a fusion protein as defined herein.

IPC Classes  ?

• C07K 14/335 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.

IPC Classes  ?

• C09C 3/06 - Treatment with inorganic compounds
• C09D 7/62 - Additives non-macromolecular inorganic modified by treatment with other compounds
• C09D 7/40 - Additives
• C09D 5/33 - Radiation-reflecting paints
• C09C 1/28 - Compounds of silicon

Abstract

Various embodiments may relate to a gas cell. The gas cell may include a chamber body. The gas cell may also include a chamber lid cooperating with the chamber body to form a space. The gas cell may further include an infrared source provided in a through hole of the chamber lid such that the infrared source extends through a thickness of the chamber lid. The gas cell may additionally include a detector provided in a through hole of the chamber body. The gas cell may further include an optical chip arranged within the space such that the optical chip is between the infrared source and the detector. The gas cell may also include three O-rings.

IPC Classes  ?

• G01N 21/3518 - Devices using gas filter correlation techniques; Devices using gas pressure modulation techniques
• G01N 21/05 - Flow-through cuvettes

Abstract

The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir

Abstract

An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.

IPC Classes  ?

• B04B 5/10 - Centrifuges combined with other apparatus, e.g. electrostatic separators; Sets or systems of several centrifuges
• C12M 1/00 - Apparatus for enzymology or microbiology
• B01D 21/26 - Separation of sediment aided by centrifugal force
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/26 - Inoculator or sampler
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01D 43/00 - Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration

Abstract

The present invention relates to a method for the manufacture of an oleogel, comprising a) homogenising an aqueous dispersion of natural food fibre to develop viscosity, b) shear-mixing the aqueous fibre dispersion with liquid edible oil at room temperature to form an emulsion, and c) subjecting the emulsion to freeze-drying to remove the water. In some embodiments, the natural food fibre is citrus fibre or nata de coco fibre mix. The invention further relates to an edible fibre-based oleogel obtained by the method, as well as food products comprising the oleogel and/or based upon the oleogel.

IPC Classes  ?

• A23D 9/04 - Working-up
• A23D 9/007 - Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
• A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides

Abstract

There is provided a neurosynaptic processing core with spike time dependent plasticity (STDP) learning for a spiking neural network, including: a spiking neuron block including a pre-synaptic block and a post-synaptic block; a synapse block communicatively coupled to the spiking neuron block; a STDP learning block communicatively coupled to the spiking neuron block and the synapse block, the STDP learning block including a pre-synaptic event accumulator including a pre-synaptic spike event memory block and a pre-synaptic spike parameter modifier; a post-synaptic event accumulator including a post-synaptic spike event memory block and a post-synaptic spike parameter modifier, a weight change accumulator, and a weight change parameter modifier; a learning error modulator; and a synaptic weight modifier configured to modify a synaptic weight parameter based on a weight change parameter and a learning error corresponding to the synaptic weight parameter. There is also provided a corresponding method of operating and a corresponding method of forming the neurosynaptic processing core.

IPC Classes  ?

• G06N 3/088 - Non-supervised learning, e.g. competitive learning
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis. The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 31/06 - Antibacterial agents for tuberculosis

Abstract

A closure for a sample tube comprises a reaction vessel. The reaction vessel comprises: at least one microfluidic mixing channel having an inlet and an outlet; at least one reaction chamber in fluid communication with the inlet and the outlet; an inlet chamber proximate the inlet of the at least one microfluidic mixing channel for introducing a portion of a sample solution from the sample tube into the at least one reaction chamber under hydrostatic pressure; and a diffusion-control feature for limiting egress of fluid from the outlet such that the portion of the sample solution introduced to the at least one reaction chamber is partitioned from the rest of the sample solution.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Determining, in a sample, the presence and/or amount of pluripotent stem cells. A sample suspected of containing one or more pluripotent stem cells is provided. The sample with a fluorescent compound is contacted under conditions that allow binding of the fluorescent compound to the pluripotent stem cells, where the fluorescent compound is a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof. The presence and/or amount of the pluripotent stem cells is determined by measuring the fluorescence of the cells following the contacting.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C12N 5/0735 - Embryonic stem cells; Embryonic germ cells
• C12N 5/074 - Adult stem cells
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Abstract

A method of producing a silicalite membrane, which includes heating an aqueous solution that includes a dopant precursor and structure-directing template agents to form silicalite seeds incorporated with a dopant, depositing a buffer layer on a ceramic substrate prior to depositing the silicalite seeds on the buffer layer, contacting the ceramic substrate with a solution including the silicalite seeds to form a silicalite layer from the silicalite seeds on the ceramic substrate, and removing the structure-directing template agents to form the silicalite membrane, where the silicalite layer includes silicalite crystals incorporated with a dopant and each of the silicalite crystals has a hollow structure which forms the pores of the silicalite layer. The silicalite membrane includes a ceramic substrate having a buffer layer formed thereon, and a silicalite layer formed on the buffer layer, where the silicalite layer includes silicalite crystals incorporated with a dopant.

IPC Classes  ?

• B01D 71/02 - Inorganic material
• B01D 69/10 - Supported membranes; Membrane supports
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/04 - Tubular membranes

Abstract

Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

IPC Classes  ?

• C08L 79/02 - Polyamines

Abstract

An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.

IPC Classes  ?

• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Abstract

Various embodiments may relate to an electro-optic modulator. The electro-optic modulator may include a waveguide configured to carry optical light along a longitudinal length of the waveguide. The electro-optic modulator may also include a first electrically conductive sub-wavelength grating on a first side of the waveguide, the first electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may further include a second electrically conductive sub-wavelength grating on a second side of the waveguide opposite the first side, the second electrically conductive sub-wavelength grating including a plurality of fingers extending substantially perpendicular to the longitudinal length of the waveguide. The electro-optic modulator may be configured to modulate the optical light upon application of a potential difference between the first electrically conductive sub-wavelength grating and the second electrically conductive sub-wavelength grating based on Pockels effect.

IPC Classes  ?

• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
• G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour by interference

Abstract

Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.

IPC Classes  ?

• G06T 7/10 - Segmentation; Edge detection
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G06T 7/64 - Analysis of geometric attributes of convexity or concavity
• G06T 7/66 - Analysis of geometric attributes of image moments or centre of gravity
• G06V 10/46 - Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
• G06T 17/00 - 3D modelling for computer graphics
• G06T 7/00 - Image analysis

Abstract

There is provided a composition comprising a slurry of capsules, the capsules having shells comprising silica and said shells encapsulating phase change materials (PCM); and a cementitious binder. There is also provided a method for preparing said composition.

IPC Classes  ?

• C09K 5/02 - Materials undergoing a change of physical state when used
• C04B 22/06 - Oxides; Hydroxides
• C04B 24/04 - Carboxylic acids; Salts, anhydrides or esters thereof
• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• C04B 24/38 - Polysaccharides or derivatives thereof

Abstract

The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy
• B29C 33/42 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present invention is in the field of molecular diagnostics and is directed to the detection of target nucleic acids in a sample using a modified CRISPR-Dx system, typically with prior amplification of the target. The modified CRISPR-Dx system comprising an engineered E174R/S542R/K548R variant of AsCas12a, wherein when get activated indiscriminately cleaves at least one detection reagent to generate signal. In one embodiment, the target nucleic acid is SARS-CoV-2 RNA.

IPC Classes  ?

• C12Q 1/6844 - Nucleic acid amplification reactions
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

A composite coating material for passive vibration damping is provided. The composite coating material includes a polymer matrix, and a piezoelectric ceramic filler and an electrically conductive filler dispersed in the polymer matrix. Particles of the piezoelectric ceramic filler have an average particle size of greater than about 100 microns (μm).

IPC Classes  ?

• G10K 11/165 - Particles in a matrix
• C09D 7/61 - Additives non-macromolecular inorganic
• C09D 7/40 - Additives
• C09D 5/24 - Electrically-conducting paints
• C09D 163/00 - Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
• C09D 137/00 - Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen; Coating compositions based on derivatives of such polymers
• C09D 123/08 - Copolymers of ethene
• C09D 113/00 - Coating compositions based on rubbers containing carboxyl groups

Abstract

There is provided a polymer or derivative thereof comprising a plurality of active amine groups in the backbone, wherein the polymer is a reaction product of a reaction between one or more bis-carbonates and one or more amine compounds having at least two terminal amino groups. Also provided are use of the polymer or derivative thereof and a method of preparing the polymer or derivative thereof.

IPC Classes  ?

• C08G 71/04 - Polyurethanes
• C11D 11/00 - Special methods for preparing compositions containing mixtures of detergents
• C11D 3/00 - Other compounding ingredients of detergent compositions covered in group
• C11D 3/37 - Polymers
• C10M 149/14 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds a condensation reaction being involved
• A01N 47/12 - Carbamic acid derivatives, i.e. containing the group —O—CO—N; Thio-analogues thereof containing a —O—CO—N group, or a thio-analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
• A01P 1/00 - Disinfectants; Antimicrobial compounds or mixtures thereof
• B01D 53/62 - Carbon oxides
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption

Abstract

This technology relates to a method of treating breast cancer in a subject and a method of determining whether a breast lesion in a subject is malignant or benign using miRNA panels.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A chemical sensor that includes a first semiconductor substrate. The chemical sensor may also include a second semiconductor substrate. The chemical sensor may further include one or more metal layers between the first semiconductor substrate and the second semiconductor substrate such that the first and second semiconductor substrates and the one or more metal layers form a cell including a cavity, the cavity having a depth of any value equal to or less than 100 μm. The chemical sensor may also include an optical source. The chemical sensor may additionally include an optical detector such that light emitted by the optical source passes through the cell to the optical detector. The first and second semiconductor substrates and the one or more metal layers may also define at least one inlet for fluid to flow into the cavity and at least one outlet for fluid to flow out of the cavity.

IPC Classes  ?

• H01L 25/16 - Assemblies consisting of a plurality of individual semiconductor or other solid state devices the devices being of types provided for in two or more different main groups of groups , or in a single subclass of , , e.g. forming hybrid circuits
• G01N 21/61 - Non-dispersive gas analysers
• H01L 23/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details of semiconductor or other solid state devices

Abstract

The invention relates generally to the field of wound healing. In one embodiment is a method for generating a delayed wound model in an animal, the method comprising contacting a wound with a composition comprising an electrospun scaffold, wherein the scaffold is made from 80% PCL and 20% rat tail collagen and has been soaked in a biofilm conditioned media from Staphylococcus aureus or a small molecular drug FK866.

IPC Classes  ?

• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61L 27/24 - Collagen
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A method of producing a silica-based superhydrophilic film. A coating formulation is provided, where the coating formulation includes an alkali metal silicate having a substantial portion of water removed therefrom, where the alkali metal silicate has a formula of M2O·nSiO2, and where M represents an alkali metal and n is a positive real number greater than zero. Furthermore, the coating formulation and an alcohol including a curing agent are mixed, where the curing agent includes an acid or an alkaline earth metal halide. Additionally, the coating formulation is dried to form the silica-based superhydrophilic film. Furthermore, a silica-based superhydrophilic film is produced according to such a method, where the silica-based superhydrophilic film includes an amine stabilizer.

IPC Classes  ?

• C09D 183/02 - Polysilicates
• C08G 77/02 - Polysilicates
• C09D 1/04 - Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances alkali metal silicates with organic additives

Abstract

A polymer having a backbone and a side unit of 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide bonded thereto, where the backbone of the polymer includes at least one heterocyclic moiety. There is also provided a process for producing the polymer as defined herein as well as a flame retardant polyolefin formulation including the polymer as defined herein and a moulded article including the flame retardant polyolefin formulation as defined herein.

IPC Classes  ?

• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule; Polyhydrazides; Polyamide acids or similar polyimide precursors
• C08K 3/32 - Phosphorus-containing compounds
• C08L 23/12 - Polypropene

Abstract

There is provided a hydrogel binder and a method of synthesizing the same. There is also provided a free-standing electrode comprising the hydrogel binder and a method of preparing the free-standing electrode comprising the hydrogel binder. There is further provided a battery comprising the free-standing electrode as defined herein.

IPC Classes  ?

• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• C08L 5/04 - Alginic acid; Derivatives thereof
• C08L 79/02 - Polyamines

Abstract

Disclosed herein is a clear cell renal cell carcinoma (ccRCC) biomarker set. Also disclosed herein is a detection system using the biomarker set disclosed herein, methods of determining whether a subject has or shows recurrence of clear cell renal cell carcinoma, method of determining whether a renal mass sample is benign or malignant, method of detecting response of a subject to systemic treatment, and a kit for carrying out the same.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

This invention relates to a portable magnetic particle imaging (MPI) device. The portable MPI device comprises a handheld probe and a processing unit. The handheld probe comprises a main housing a first sensor coil, a second sensor coil, a transmitter coil arranged between the first and second sensor coils, and an excitation priming frame housing magnetic component and the processing unit comprises a transmitter communicatively connected to the transmitter coil and the excitation priming frame, a receiver communicatively connected to the first and second sensor coils.

IPC Classes  ?

• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• A61B 5/0515 - Magnetic particle imaging
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

There is provided a coral-like composite material comprising highly dispersed conductive metal nitride, metal carbide or metal carbonitride nanoparticles on mesoporous carbon nanosheets, and a method of preparing the same. There is also provided a coating material for a modified separator of a lithium-sulfur battery comprising the coral-like composite material as described herein, a conducting carbon material and a binder, and a method of preparing the same.

IPC Classes  ?

• C01B 32/158 - Carbon nanotubes
• C01B 32/914 - Carbides of single elements
• H01M 50/431 - Inorganic material
• H01M 10/052 - Li-accumulators
• H01M 10/058 - Construction or manufacture
• C01B 21/06 - Binary compounds of nitrogen with metals, with silicon, or with boron
• C01B 21/082 - Compounds containing nitrogen and non-metals

Abstract

There is provided a method of forming a structure that is in contact with an object, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be in contact with the object; and (ii) crosslinking at least part of the flowable precursor that is in contact with the object to form a structure that is in contact with the object, wherein a top surface of the part of the flowable precursor that is to be crosslinked, is in interface with a fluid medium. Also provided is a system for performing the method.

IPC Classes  ?

• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/06 - Titanium or titanium alloys
• B29C 64/245 - Platforms or substrates
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present disclosure generally relates to a method of fabricating a graded metallic structure by additive manufacturing and the graded metallic structure thereof. The method comprises preparing a material powder in a supply container, the material powder is partitioned into a plurality of longitudinal volumes and comprises different metallic powders, performing an additive manufacturing process comprising supplying layers of the material powder from the supply container, displacing the layers of material powder to a fabrication platform and fusing the layers of material powder on the fabrication platform to form the graded metallic structure, wherein at least one longitudinal volume has a varying transverse cross-sectional area and at least one longitudinal volume has a varying longitudinal cross-sectional area, such that the fused metallic powders in the graded metallic structure are graded along the longitudinal and the transverse. This method is proven to be effective to make graded metal parts with composition gradients in two dimensions.

IPC Classes  ?

• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
• B22F 10/38 - Process control to achieve specific product aspects, e.g. surface smoothness, density, porosity or hollow structures
• B22F 10/37 - Process control of powder bed aspects, e.g. density
• B22F 1/00 - Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
• B22F 9/08 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from liquid material by casting, e.g. through sieves or in water, by atomising or spraying
• B22F 9/04 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from solid material, e.g. by crushing, grinding or milling

Abstract

Abstract: Various embodiments may relate to a power module package. The power module package may include a power module including a first lead frame, a second lead frame, and at least one chip at least partially between the first lead frame and the second lead frame. The power module package may also include a first heat spreader attached to the first lead frame. The power module package may further include a second heat spreader also attached to the first lead frame such that the first lead frame, the first heat spreader and the second heat spreader form an enclosure defining a cavity containing the at least one chip. The enclosure may include an inlet configured to allow a cooling medium to flow into the cavity and an outlet configured to allow the cooling medium to flow out of the cavity.

IPC Classes  ?

• H01L 25/18 - Assemblies consisting of a plurality of individual semiconductor or other solid state devices the devices being of types provided for in two or more different subgroups of the same main group of groups , or in a single subclass of ,
• H01L 23/495 - Lead-frames
• H01L 23/367 - Cooling facilitated by shape of device
• H01L 23/427 - Cooling by change of state, e.g. use of heat pipes
• H01L 23/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details of semiconductor or other solid state devices
• H01L 25/00 - Assemblies consisting of a plurality of individual semiconductor or other solid state devices

Abstract

The present disclosure provides a pharmaceutical composition comprising an Agrin fragment or derivative thereof, and uses of the pharmaceutical composition. The present disclosure also provides method of producing the pharmaceutical composition.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using as an immunogen a peptide or polypeptide comprising: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration. Also provided are antibodies produced by such methods, and uses thereof.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61P 35/00 - Antineoplastic agents
• A61K 49/00 - Preparations for testing in vivo
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

Disclosed is a method for assessing the transduction efficiency and/or specificity of vectors at single cell level.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The present invention relates to a soluble dimeric fusion protein comprising a first and second polypeptides, wherein the first and second polypeptides each comprises a Dectin-1 receptor polypeptide fused to a human Fc domain via a dimerization linker. Methods of using the soluble dimeric fusion protein for immunizing a subject against a fungal infection, preventing or treating a fungal infection in a subject and detecting a fungal infection in a subject are also provided. In one embodiment, a chimeric molecule comprising the fusion protein and a payload is provided. In one embodiment, the payload is Amphotericin B.

IPC Classes  ?

• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants

Abstract

A method for forming a transition metal dichalcogenide monolayer, which includes depositing a transition metal, a transition metal oxide, or a mixture thereof, on a substrate, introducing a chalcogen precursor to the transition metal, the transition metal oxide, or the mixture thereof, in the presence of an etching gas and a carrier gas at a first temperature, to form a transition metal dichalcogenide on the substrate from the transition metal, the transition metal oxide, or the mixture thereof, and subliming the transition metal dichalcogenide on the substrate in the presence of a pulsating supply of a vapor of the chalcogen precursor to form the transition metal dichalcogenide monolayer at a second temperature, wherein the vapor of the chalcogen precursor comprises a chalcogen vapor.

IPC Classes  ?

• C23C 16/02 - Pretreatment of the material to be coated
• C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
• C23C 14/08 - Oxides
• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• C23C 16/46 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for heating the substrate
• C23C 14/58 - After-treatment
• C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

A light-acoustic system and method for detecting an anomaly in a structure are provided. The system includes a light source configured to emit an excitation light and at least one excitation element attached to a surface of a structure. The at least one excitation element includes a photostrictive material and is configured to receive the excitation light for generating an oscillating strain. The oscillating strain generates an acoustic wave in the structure. The system also includes a detector configured to detect the acoustic wave.

IPC Classes  ?

• G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves
• G01N 29/04 - Analysing solids

Abstract

A grid and skin assembly for use in a composite laminate structure is described. The assembly includes a metallic grid having a plurality of intersecting ribs oriented in at least two distinct rib directions offset at a grid angle relative to one another and defining respective intersection points; and a composite laminate skin having a plurality of ply layers comprising a plurality of tapes oriented in at least two distinct tape directions offset at a ply angle relative to one another. The grid angle is at least 25 degrees, the intersection points define glueless joints of the metallic grid, and the grid is a non-aluminum-based material. A grid and method of manufacturing the grid and skin assembly is also described. The method includes a water jet cutting procedure and glueless joint formation due to differing thermal expansion characteristics of the grid and skin.

IPC Classes  ?

• B32B 3/26 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a layer with cavities or internal voids
• B32B 3/12 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by a discontinuous layer, i.e. apertured or formed of separate pieces of material characterised by a layer of regularly-arranged cells whether integral or formed individually or by conjunction of separate strips, e.g. honeycomb structure
• B32B 3/06 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by features of form at particular places, e.g. in edge regions for attaching the product to another member, e.g. to a support
• B32B 3/08 - Layered products essentially comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar form; Layered products essentially having particular features of form characterised by features of form at particular places, e.g. in edge regions characterised by added members at particular parts
• B32B 7/03 - Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical propert; Layered products characterised by the interconnection of layers with respect to the orientation of features
• B32B 15/18 - Layered products essentially comprising metal comprising iron or steel
• B32B 38/00 - Ancillary operations in connection with laminating processes

Abstract

A method of synthesizing a polymeric clay composition for coating. A clay-polyacrylate composite is produced, where the clay-polyacrylate composite includes one or more layers of clay intercalated with polyacrylate, where the one or more layers of clay include at least one organosilane coupling agent including an acrylate moiety, where the at least one organosilane coupling agent is attached to a surface of the one or more layers of clay and the polyacrylate is covalently attached to the organosilane coupling agent, and where the polyacrylate consists of a first acrylate monomer and a second acrylate monomer having different solubility, where the first acrylate monomer is a hydrophilic acrylate monomer including a hydroxyl (—OH) group and the second acrylate monomer is a hydrophobic acrylate monomer which repels water. Furthermore, the clay-polyacrylate composite is mixed with a solution including a polymer to form the polymeric clay composition.

IPC Classes  ?

• C09D 133/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
• C08F 292/00 - Macromolecular compounds obtained by polymerising monomers on to inorganic materials
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08F 2/18 - Suspension polymerisation
• C08K 5/14 - Peroxides
• C08K 5/5425 - Silicon-containing compounds containing oxygen containing at least one C=C bond
• C08K 9/04 - Ingredients treated with organic substances
• C08K 3/34 - Silicon-containing compounds
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids

Abstract

A method for determining the health status of an elderly individual by testing the sample extracted from the individual for the presence of biomarkers, the bio markers being autoantibodies to antigens comprising MAPK13, CD96, FKBP3, PPM1A, PHLDA1, GLRX3, FEN1 and AURKA, wherein the antigens may further comprise one or more of UBE2I, AAK1, YARS, ASPSCR1, CASP10, FHOD2, TCL1A and MAP4, wherein PHLDA1 and CD96 correspond to healthy, AURKA, FEN1, CASP10 and AAK1 correspond to intermediate health, and UBE2I, YARS, ASPSCR1, FHOD2, TCL1A, MAP4, MAPK13, FKBP3, PPM1A and GLRX3 correspond to unhealthy.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 33/564 - Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

There is provided a microfluidic device comprising a first region configured to hold target cells, e.g., tumor cells, a second region configured to hold effector cells, e.g., immune cells, and an array of microstructures disposed between the first and second regions, wherein the first region is in fluid communication with the second region, and wherein the array of microstructures is configured to selectively allow movement of immune cells, from the second region to an interaction zone that is at least partially disposed within the first region, for interaction with tumor cells in the interaction zone. The array of microstructures can be an array of micropillars. Also provided is a chip comprising a plurality of the device and a method of studying interactions of a first cell type with a second cell type.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

A method of synthesizing a clay-polyacrylate composite. An aqueous solution including clay is mixed with at least one organosilane coupling agent including an acrylate moiety to form a silanized-clay suspension. The silanized-clay suspension is contacted with a first acrylate monomer and a second acrylate monomer in an inert environment, where the first acrylate monomer and the second acrylate monomer have different solubility. A polymerization initiator is added to the silanized-clay suspension before or during the contacting of the silanized-clay suspension with the first acrylate monomer and the second acrylate monomer in the inert environment to form the clay-polyacrylate composite including the first and second acrylate monomer, where the first acrylate monomer is a hydrophilic acrylate monomer including a hydroxyl (—OH) group and the second acrylate monomer is a hydrophobic acrylate monomer which repels water.

IPC Classes  ?

• C09D 133/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
• C08F 292/00 - Macromolecular compounds obtained by polymerising monomers on to inorganic materials
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08F 2/18 - Suspension polymerisation
• C08K 5/14 - Peroxides
• C08K 5/5425 - Silicon-containing compounds containing oxygen containing at least one C=C bond
• C08K 9/04 - Ingredients treated with organic substances
• C08K 3/34 - Silicon-containing compounds
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids

Abstract

There is provided a method of identifying a neutrophil progenitor, the method comprising: determining an expression of at least one biomarker selected from the group consisting of: CD71, LOX-1, CD164, CD112, CD181, TACSTD2, CD11b and CD49d in a cell. In various embodiments, the cell is identified as a neutrophil progenitor when it is determined to have at least one of the following expression profiles: CD71hi/+, LOX-1int/lo/−, CD164hi/+, CD112hi/+, CD181int/lo/−, TACSTD2hi/+, CD11blo/− and/or CD49dint/hi/+. Also disclosed are a method of sorting and/or separating neutrophil progenitors from a cell population, a composition that is enriched in neutrophil progenitors and related uses and methods.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A spatial light modulator and a method for forming the spatial light modulator. The spatial light modulator may include a first reflector. The spatial light modulator may also include a second reflector. The spatial light modulator may further include a liquid crystal layer between the first reflector and the second reflector. The first reflector may include a first electrode. The second reflector may include a second electrode. At least one reflector selected from the first reflector and the second reflector may be or may include a distributed Bragg reflector (DBR). The first reflector and the second reflector may form a Fabry-Perot (FP) cavity.

IPC Classes  ?

• G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors

Abstract

A system for monitoring foetal growth. The system may include a plurality of devices. Each device of the plurality of devices may be configured to determine measurements of a baby bump over a time period, and may be further configured to store the measurements. The system may also include a server configured to receive the measurements from each of the plurality of devices. The server may be configured to compare the measurements from different devices of the plurality of devices. The system may be further configured to send an alert upon detecting an abnormality based on the measurements from the different devices of the plurality of devices.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

IPC Classes  ?

• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

The present invention provides methods, antibodies and kits for detecting and/or quantifying expression of both non-nucleic acid molecules, such as proteins, and nucleic acid molecules in a single sample or single cell. The antibody is covalently conjugated to an oligonucleotide, such as a single-stranded DNA molecule, which comprises an identification tag and a blocking group, such as a ddNTP or an inverted dTTP, which prevents extension of the oligonucleotide by a polymerase. The method comprises the steps of reverse transcribing the conjugated oligonucleotide and the target nucleic acid simultaneously, amplifying both transcription production, and detecting the amplicons thereof. The method is also useful for detecting and/or quantifying the number of cells in a sample expressing a given non -nucleic acid molecule (e.g. protein).

IPC Classes  ?

• C12Q 1/6851 - Quantitative amplification
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

Disclosed is an apparatus for disinfection comprising a cylindrical housing; a plurality of ultra-violet light emitting diode (UV-LED) modules disposed on the circumference of the cylindrical housing, each UV-LED module comprising a heat sink; and a heat dissipation module disposed along the central axis of the cylindrical housing, the heat dissipation module arranged in thermal contact with the heat sink of each of the plurality of UV-LED modules; wherein each of the plurality of UV-LED modules is pivotably mounted onto the circumference.

IPC Classes  ?

• A61L 2/24 - Apparatus using programmed or automatic operation
• A61L 2/10 - Ultraviolet radiation

Abstract

There is provided a method of identifying pro-inflammatory dendritic cells, the method comprising: determining an expression of CD5, CD14 and/or CD163 in cells, wherein CD5−, CD14+ and/or GD163+ cells are identified as pro-inflammatory dendritic cells. Also disclosed is a method of characterising inflammation and/or inflammatory disease in a subject, the method comprising: determining a proportion of CD5−, CD14+ and/or GD163+ dendritic cells in the subject's sample, wherein the proportion positively correlates with the level of inflammation and/or the severity of inflammatory disease in the subject.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A portable device which detects a Raman signal from an analyte of interest contained in or suspected to contain in a sample. The portable device includes a laser source in optical communication with a dichroic mirror, an objective lens optically positioned to consolidate the laser from the laser source to the sample, (i) a pair of rotatable filters in optical communication with the dichroic mirror and an optical transmission module or (ii) a first band-pass filter in optical communication with the dichroic mirror and an optical transmission module, and a detector optically positioned to receive and detect a Raman signal produced from the laser incident on the analyte of interest. The dichroic mirror directs the laser from the laser source to the sample through the objective lens and transmits any Raman signal from the sample toward the detector. The detector is absent of a spectrometer and detects the Raman signal.

IPC Classes  ?

• G01N 21/65 - Raman scattering

Abstract

The present invention relates, in general terms, to hydrogels and their uses thereof. The hydrogels demonstrate toughness; i.e. the ability to absorb energy and plastically deform without fracturing. The present invention also relates to methods of fabricating hydrogels. In particular, the method of fabricating a tough hydrogel comprises polymerising a plurality of charged monomers in the presence of multivalent ions in order to form an ion impregnated hydrogel and exposing the ion impregnated hydrogel to heat in order to form the tough hydrogel.

IPC Classes  ?

• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C08F 2/46 - Polymerisation initiated by wave energy or particle radiation
• C08F 2/28 - Emulsion polymerisation with the aid of emulsifying agents cationic
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08F 222/38 - Amides

Abstract

This disclosure relates to a current-to-digital converter suitable for wide-ranging current sensing applications. In particular, the current-to-digital converter comprises a delta-sigma analogue-to-digital converter which utilizes a successive-approximation-register to control a modulation of the sensed current so that the digital conversion of the modulated sensed current by the delta-sigma analogue-to-digital converter may be done with high precision.

IPC Classes  ?

• H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter
• H03M 3/00 - Conversion of analogue values to or from differential modulation

Abstract

The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

IPC Classes  ?

• C07D 473/06 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• C07D 473/08 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Abstract

The present application discloses methods useful for the multiplex measurement of enzymatic activities. Also disclosed are polynucleotide constructs, constructs libraries and compartments related suitable for use in the methods.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/22 - Ribonucleases
• C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof
• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

The present invention provides a method of prophylaxis or treatment of airway inflammation and/or related complications triggered by Enterovirus 3C protease-activated NLRP1, a compound or composition comprising said compound for use in the method, and use of said compounds in medicament preparation for the prophylaxis or treatment of human airway inflammation and/or related complications triggered by Enterovirus 3C protease-activated NLRP1.

IPC Classes  ?

• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 38/06 - Tripeptides
• A61K 31/69 - Boron compounds
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Methods of treating and preventing diseases associated with fibrosis are disclosed, as well as agents for use in such methods. The methods comprise inhibiting at least one of ITFG1, MFAP4, GRHPR, ABCC4, PAK3, TRNP1, APLN, KIF20A, and/or LTB. In one embodiment, the disease is a liver disease or condition. Also disclosed are methods of promoting regeneration of cells, such as hepatocytes.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates, in general terms, to piezoelectric thin films with an empirical formula (K1xNax)yNbO3, wherein 0≤x≤1 and 0.64≤y≤0.95. In particular, the piezoelectric thin film comprises at least two adjacent NbO2 planes in an antiphase boundary, the at least two adjacent NbO2 planes displaced from each other by about half a lattice length in either the (100), (010) or (100) crystallographic plane. The present invention also relates to methods of fabricating the piezoelectric thin films.

IPC Classes  ?

• C01G 33/00 - Compounds of niobium
• H10N 30/00 - Piezoelectric or electrostrictive devices
• H10N 30/853 - Ceramic compositions
• H10N 30/076 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by vapour phase deposition

Abstract

The present invention relates to signalling catalytic nucleic acid nanostructures that are responsive to polymerase activity, methods of their use, devices and kits comprising the same. More specifically, the present invention provides a catalytic signalling nanostructure comprising a DNAzyme/RNAzyme, such as G-quadruplex hemin, and a polymerase—responsive element. Polymerase elongation of the polymerase-responsive element eliminates catalytic activity of the DNAzyme/RNAzyme. The catalytic nucleic acid nanostructure can be used alone or paired with a target recognition nanostructure which can transduce molecular signals into polymerase activity, in an integrated circuit.

IPC Classes  ?

• C12Q 1/682 - Signal amplification
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

The invention relates to treating a plant-based material with an agent and/or a force to enable the plant-based material to mimic the colour of animal products, wherein the agent and/or force is capable of controlled permeabilisation of cell membrane to thereby release polyphenols from the cells of the plant-based material to allow polyphenol-cell wall interaction and/or causes the oxidation of polyphenols in the plant-based material. Also disclosed is a plant-based food product, such as plant-based meat substitutes, produced by the process thereof.

IPC Classes  ?

• A23J 3/14 - Vegetable proteins
• A23L 5/40 - Colouring or decolouring of foods
• A23J 3/22 - Working-up of proteins for foodstuffs by texturising

Abstract

There is provided a lighting system comprising a light source, and a cooling system with temperature sensing and responding capability coupled to the light source for maintaining a temperature of the light source within a defined variation from a set temperature. There are also provided a method of adjusting a temperature of a light source and a method of assembling the lighting system. There is further provided an additive manufacturing system for three-dimensional printing comprising the lighting system.

IPC Classes  ?

• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
• B29C 64/277 - Arrangements for irradiation using multiple radiation means, e.g. micromirrors or multiple light-emitting diodes [LED]
• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor

Abstract

There is provided a method of synthesizing a single-stranded nucleotide sequence, the method comprising adding a blocked nucleoside triphosphate to an initiator nucleotide sequence to incorporate a corresponding blocked nucleotide thereto in the presence of a polymerase, wherein the blocked nucleoside triphosphate has one of the general formulae (I), (II), (III), (IV), (V) and (VI).

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 19/10 - Pyrimidine radicals with the saccharide radical being esterified by phosphoric or polyphosphoric acids
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Abstract

A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.

IPC Classes  ?

• A61K 31/795 - Polymers containing sulfur
• C08G 64/02 - Aliphatic polycarbonates
• A61P 31/14 - Antivirals for RNA viruses

Abstract

We describe a method of diagnosis of a dermatological condition such as atopic dermatitis (AD) in an individual. The method comprises detecting the activity or expression level of miR-335 in a sample of or from an individual. We also disclose the use of a histone deacetylase (HDAC) inhibitor such as belinostat (PubChem CID: 6918638) in the preparation of a medicament for the restoration of barrier function or for the treatment of a dermatological condition such as atopic dermatitis.

IPC Classes  ?

• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61P 17/00 - Drugs for dermatological disorders
• A61K 31/18 - Sulfonamides
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

This invention relates to a resin composition comprising at least one of a first monomeric or oligomeric component (A), at least one of a second monomeric or oligomeric component (B) and a photoinitiator. This invention also relates to a method of preparing a polymer from the resin composition, a polymer prepared from the resin composition, a method of forming a 3-dimensional printed article, and a kit comprising at least one of a first monomeric or oligomeric component (A), at least one of a second monomeric or oligomeric component (B) and a photoinitiator.

IPC Classes  ?

• C08L 33/10 - Homopolymers or copolymers of methacrylic acid esters
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

A method of producing a porous carbon composite fibrous mats formed of a network of carbon fibers incorporated with porous carbon particles. The method includes electrospinning a polymer solution to form a porous layer of polymeric fibers and the polymeric fibers are doped with a precursor of conductive metal particles, where the polymer solution includes a polymer and the precursor of the conductive metal particles, electrospraying a metal organic framework suspension onto the porous layer of polymeric fibers, where the metal organic framework suspension includes metal organic framework particles, repeating the electrospinning and electrospraying in an alternating manner to form a porous network of polymeric fibers incorporated with the metal organic framework particles, and heating the porous network of polymeric fibers incorporated with the metal organic framework particles to form the porous carbon composite fibrous mats.

IPC Classes  ?

• B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection

Abstract

The present invention relates to a method and system for introducing one or more exogenous substances into an immune cell. The method comprises the steps of: providing a membrane having a plurality of pores configured to allow the immune cell to pass through, wherein the plurality of pores has an average pore diameter which is no less than an average diameter of the immune cell nucleus and no more than an average diameter of the immune cell, passing a fluid containing the immune cell and the on e or more exogenous substances through the plurality of pores to induce a mechanical stress to the immune cell and facilitate introduction of the one or more exogenous substances into the immune cell, and recirculating the fluid containing the immune cell and the one or more exogenous substances such that the same immune cell passes through the membrane more than once. In some embodiments, the immune cell is T-cells and the exogenous substance is mRNA.

IPC Classes  ?

• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

Various embodiments may relate to a tunable optical device. The tunable optical device may include a ferroelectric layer including a ferroelectric material. The tunable optical device may also include one or more first electrodes on a first side of the ferroelectric layer. The tunable optical device may further include one or more second electrodes on a second side of the ferroelectric layer opposite the first side. A refractive index of the ferroelectric material may be changeable in response to a potential difference applied between the one or more first electrodes and the one or more second electrodes. The one or more first electrodes and the one or more second electrodes may be configured to allow visible light or infrared light to pass through.

IPC Classes  ?

• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the position or the direction of light beams, i.e. deflection

Abstract

There is provided a method of communication between functional blocks in a system-on-chip. The method includes: exchanging a respective public key between a first functional block and a second functional block in the system-on-chip (SoC) for a communication therebetween, the first functional block being a transmitter of the communication and the second function block being a receiver of the communication; generating, at the first functional block, a first code based on the public key of the second functional block; generating, at the second functional block, a second code based on the public key of the first functional block; obfuscating, at the first functional block, an address associated with the communication based on the first code to produce an obfuscated address; transmitting, at the first functional block, the obfuscated address to the second functional block via an interconnect communication infrastructure in the system-on-chip; receiving, at the second functional block, the obfuscated address from the first functional block via the interconnect communication infrastructure; and deobfuscating, at the second functional block, the obfuscated address received based on the second code to produce a deobfuscated address associated with the communication. There is also provided a corresponding system-on-chip.

IPC Classes  ?

• H04L 9/08 - Key distribution
• H04L 9/00 - Arrangements for secret or secure communications; Network security protocols
• H04L 9/12 - Transmitting and receiving encryption devices synchronised or initially set up in a particular manner

Abstract

This invention relates to a a one-step process for making a polymer composite suspension for coating plastic films characterized in that a first polymer is synthesized in-situ optionally in the presence of other polymers and in the presence of clay. Preferably the polymer composite suspension comprises a) 1.0 to 11.0 wt % of clay or silane modified clay, b) 0.1 to 10.0 wt % of poly (acrylic acid), which is a copolymer of acrylic acid (AA) with at least one other monomer selected from 2-ethylhexyl acrylate (ERA), β-carboxyethyl acrylate (β-CEA), methacrylamidoethyl ethylene urea (WAM II) and ethoxylated behenyl methacrylate (β-EHA), c) 1.0 to 15.0 wt % of other polymers, preferably poly (vinyl alcohol) and d) 70 to 97 wt % of water or mixture of water with 2-propanol. The coating films made from the suspensions show good barrier capabilities against water vapor and oxygen can be used to make barrier layers on or within plastic films for packaging applications. The invention also relates to methods for making silane modified clay usable in the process for making the suspensions.

IPC Classes  ?

• C08F 20/06 - Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
• C09D 133/02 - Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• C08J 7/04 - Coating
• C08J 7/043 - Improving the adhesiveness of the coatings per se, e.g. forming primers
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
• C08J 7/048 - Forming gas barrier coatings

Abstract

The present invention relates to peptides and their ability to identify and bind to T cells specific for HBV-infected hepa-tocytes. In an first aspect of the invention, there is provided a peptide comprising an amino sequence selected from the group consisting of STLPETAVVRR, STLPETAVVR, STLPETTVVRR, STLPETTVIRR, STPPETTVVRR, STLPETTVVGR and STIPETTVVRR, wherein the peptide is derived from Hepatitis B virus core169 and is capable of binding HLA-A*1101 and when bound to HLA-A*1101 s capable of identifying T cells specific for Hepatitis B virus. In a second aspect of the invention, there is provided A T cell expressing a T cell receptor (TCR) molecule, wherein the TCR molecule comprises an amino acid sequence selected from the group comprising: CASGDSNSPLHF, CASSGGQIVYEQYF, CSARGGRGGDYTF and CASSQDWTEAFF, the T cell receptor is able to bind to a pep-tide according to the first aspect of the invention.

IPC Classes  ?

• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 39/29 - Hepatitis virus
• C12N 15/86 - Viral vectors

Abstract

This invention relates to methods and compositions for amplifying nucleic acids, e.g., genomic DNA, using nicking agents. The method of amplifying nucleic acids comprising: (a) forming a reaction mixture comprising: (i) a first nucleic acid template comprising a strand having a first nicking agent recognition sequence; (ii) a second nucleic acid template comprising a strand having a second nicking agent recognition sequence; (iii) at least one primer for a target region on the first or second nucleic acid template; (iv) at least one protein having DNA polymerase domain function, wherein the domain function comprises a first domain function capable of strand displacement activity and a second domain function capable of high processivity activity, or at least one protein having DNA polymerase domain function capable of strand displacement activity and at least one protein having DNA polymerase domain function capable of high processivity activity; (v) at least one deoxynucleoside triphosphate; and (vi) a first nicking agent for recognizing the first nicking agent recognition sequence and a second nicking agent for recognizing the second nicking agent recognition sequence; (b) incubating the reaction mixture under conditions that amplifies the nucleic acid templates, wherein the domain functions capable of strand displacement activity and high processivity activity are separate from each other and capable of carrying out their activities simultaneously. In specific embodiments, the nicking agent is NB.BsrDI and the proteins having DNA polymerase domain functions are Bst 3.0 polymerase and Pfu polymerase.

IPC Classes  ?

• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

The invention provides compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein the variables are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (K-Ras) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose. The invention provides compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein the variables are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (K-Ras) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

IPC Classes  ?

• A61K 38/12 - Cyclic peptides
• A61P 35/00 - Antineoplastic agents
• C07K 7/52 - Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring