Shimadzu Corporation

Japan

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G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode 615
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1.

GAS ANALYSIS DEVICE

      
Application Number 18279295
Status Pending
Filing Date 2021-10-21
First Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Senda, Atsuko
  • Itabashi, Toshihisa

Abstract

Provided is a gas analyzer capable of facilitating the treatment of water generated from an analysis target gas and collected in a drain pot. A gas analyzer 10 includes: an analysis target gas flow path 13 through which an analysis target gas flows; a cooling unit 14 which is provided in the analysis target gas flow path 13 and configured to cool the analysis target gas; a drain flow path 141 through which liquid generated in the cooling unit 14 is discharged; a closed container 20 connected to the drain flow path 141; a selective permeation member 211 which is a member partitioning the inside of the closed container 20 into the drain introduction space 200 connected to the drain flow path 141 and a gas introduction space 210 and configured to selectively let gas-phase water permeate from the drain introduction space 200 to the gas introduction space 210; a gas source 22 configured to introduce a gas into the gas introduction space 210; and a gas discharge port 26 through which a gas in the gas introduction space 210 is discharged

IPC Classes  ?

  • G01N 1/22 - Devices for withdrawing samples in the gaseous state
  • G01N 1/24 - Suction devices
  • G01N 1/40 - Concentrating samples
  • G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

2.

DUAL PHASE DIFFERENCE PUMP

      
Application Number 18509626
Status Pending
Filing Date 2023-11-15
First Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor Kokabu, Takuya

Abstract

A dual phase difference pump 100 that can reduce the pulsation of a discharge pressure as much as possible. The dual phase difference pump 100 includes, in series, two gear pump units 1, 2 each including a pair of gears 4, 5 configured to mesh with each other. Shafts 42 of the gear pump units 1, 2 are coupled to each other by using a coupler 6. The pair of gears 4, 5 mesh with each other without backlash. The coupler 6 is configured to couple the shafts 42 to each other at any one of a plurality of predetermined phase angles, and is configured to make a phase difference between the gear pump units 1, 2 equal irrespective of which predetermined phase angle is selected among the plurality of predetermined phase angles as a phase angle at which the shafts 42 are coupled to each other.

IPC Classes  ?

  • F16D 1/116 - Quick-acting couplings in which the parts are connected by simply bringing them together axially having retaining means rotating with the coupling and acting by interengaging parts, i.e. positive coupling the interengaging parts including a continuous or interrupted circumferential groove in the surface of one of the coupling parts
  • F04C 2/08 - Rotary-piston machines or pumps of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing

3.

OLIGONUCLEOTIDE DISPLAY PROCESSING DEVICE

      
Application Number JP2022044485
Publication Number 2024/116397
Status In Force
Filing Date 2022-12-01
Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Uchiyama, Kosuke
  • Hirama, Tomohiro
  • Kato, Noriko

Abstract

An oligonucleotide display processing device according to the present invention comprises: an input reception unit (34) that receives input of base information, sugar information, and phosphate group information of each of a plurality of nucleotides forming a target oligonucleotide, and arrangement information of the plurality of nucleotides; a storage unit (35) having pre-stored therein labels which each include at least one of a character or a symbol, and which are base labels corresponding to the base information, sugar labels corresponding to the sugar information, and phosphate group labels corresponding to the phosphate group information; an extraction unit (45) that extracts, from the storage unit, base labels, sugar labels, and phosphate group labels respectively corresponding to the base information, the sugar information, and the phosphate group information received by the input reception unit; and an output unit (46) that arranges, on the basis of the arrangement information of each of the nucleotides, the base labels, the sugar labels, and the phosphate group labels of the plurality of nucleotides extracted by the extraction unit, and disposes and displays, on a display unit (24), the base labels, the sugar labels, and the phosphate group labels of the respective nucleotides such that base labels of adjacent nucleotides are arranged side by side. The present invention enables easy understanding of the structure of oligonucleotides.

IPC Classes  ?

  • G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

4.

METHOD FOR QUANTIFYING ANALYTE CONTAINING MYCOPHENOLIC ACID AND ONE OR MORE OTHER IMMUNOSUPPRESSANTS IN TARGET BLOOD SAMPLE

      
Application Number JP2023042587
Publication Number 2024/117136
Status In Force
Filing Date 2023-11-28
Publication Date 2024-06-06
Owner
  • JICHI MEDICAL UNIVERSITY (Japan)
  • SHIMADZU CORPORATION (Japan)
Inventor
  • Aizawa Kenichi
  • Iwami Daiki
  • Sakuma Yasunaru

Abstract

The present invention provides a means for quantifying and analyzing an analyte containing a mycophenolic acid and one or more other immunosuppressants by using the whole blood fraction without separating a blood sample. One aspect of the present invention pertains to a method for quantifying an analyte containing a mycophenolic acid and one or more other immunosuppressants in a target blood sample, the method comprising: an analyte concentration measurement step for measuring the concentration of an analyte containing a mycophenolic acid and one or more other immunosuppressants in the whole blood fraction of the blood sample; a hematocrit value acquisition step for acquiring a hematocrit value of the target blood sample; and a mycophenolic acid concentration conversion step for converting the concentration of the mycophenolic acid in the whole blood fraction of the blood sample to the concentration of the mycophenolic acid in a plasma fraction of the blood sample on the basis of the hematocrit value.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • A61K 31/365 - Lactones
  • A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

5.

Mass Spectrometer

      
Application Number 18285119
Status Pending
Filing Date 2021-05-14
First Publication Date 2024-06-06
Owner Shimadzu Corporation (Japan)
Inventor Ueno, Yoshihiro

Abstract

One mode of the mass spectrometer according to the present invention is a mass spectrometer including an ion source configured to ionize a component contained in a sample gas, the ion source (3) including: an ionization chamber (30) having an ion ejection opening (301) and forming a space substantially partitioned from an outside inside the ionization chamber; a thermal electron supply unit (32) configured to supply thermal electrons to an inside of the ionization chamber; a magnetic field forming unit (34, 35) configured to form a magnetic field inside the ionization chamber such that the thermal electrons move helically; and a deflection electric field forming unit (37, 7) configured to form a deflection electric field deflecting ions derived from the component generated in the ionization chamber by a direct or indirect action of the thermal electrons in a direction against a force received from the magnetic field when the ions are moving toward the ion ejection opening.

IPC Classes  ?

  • H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
  • H01J 49/06 - Electron- or ion-optical arrangements
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

6.

X-RAY IMAGING APPARATUS, IMAGE PROCESSING APPARATUS, AND IMAGE PROCESSING PROGRAM

      
Application Number 18285144
Status Pending
Filing Date 2021-12-27
First Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Hu, Erzhong
  • Hosomi, Naomasa

Abstract

An X-ray imaging apparatus is provided with an X-ray irradiation unit, an X-ray detection unit, an X-ray image generation unit, a display unit, and a control unit. The control unit includes an enhanced image generation unit that generates, as an enhanced image, at least one of an output image of a trained model and a composite image generated based on the output image and the X-ray image, based on the trained model, and an image output unit configured to make the display unit display the X-ray image and at least one of the output image and the composite image simultaneously or switchably.

IPC Classes  ?

  • A61B 6/12 - Devices for detecting or locating foreign bodies
  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
  • A61B 6/46 - Arrangements for interfacing with the operator or the patient
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

7.

MEDICAL IMAGING APPARATUS

      
Application Number JP2023033018
Publication Number 2024/116540
Status In Force
Filing Date 2023-09-11
Publication Date 2024-06-06
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka Masahiro

Abstract

Provided is a medical imaging apparatus with which it is possible to flexibly execute appropriate assistance for an operator performing complex imaging. An X-ray imaging apparatus 10 according to the present invention comprises: a console 11 which allows an operator to input a description; an information processing unit 13 which associates an imaging type with the content of the description provided by the operator; a memory 21 which stores the content of the description by the operator in association with the imaging type; an imaging type acquisition unit 14 which acquires a type of imaging to be executed; and a display unit 12 which reads out the content of the description by the operator corresponding to the acquired imaging type from the memory 21 and displays said content.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

8.

Sample pretreatment device

      
Application Number 29856464
Grant Number D1030089
Status In Force
Filing Date 2022-10-13
First Publication Date 2024-06-04
Grant Date 2024-06-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Tsukamoto, Yuji

9.

DATA PROCESSING SYSTEM

      
Application Number 18204413
Status Pending
Filing Date 2023-06-01
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Kawase, Tomohiro

Abstract

A data processing system (1) including a data holder (8) that holds analysis data including mass spectrometry data acquired by a mass spectrometer (100) in an analysis of a sample using a chromatograph mass spectrometer and measurement data acquired by a detector, that is not mass spectrometer, in the analysis of the sample, a data processor (10) configured to perform data processing by using the analysis data held in the data holder (8), and an information displayer (12) configured to display data processed by the data processor (10). The data processor (10) is configured to create a chromatogram based on the measurement data, and identify a peak portion in which peaks of a plurality of components overlap to form one peak shape among peak portions on the chromatogram as a coelution peak by using a correspondence relationship between the chromatogram and the mass spectrometry data, and when displaying the chromatogram, the information displayer (12) is configured to display a peak portion identified as the coelution peak by the data processor (10) in a mode different from that of another peak portion.

IPC Classes  ?

10.

Method for Detecting Coronavirus Infection

      
Application Number 18281094
Status Pending
Filing Date 2022-03-09
First Publication Date 2024-05-30
Owner
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY (Japan)
  • SHIMADZU CORPORATION (Japan)
  • AiSTI SCIENCE Co., Ltd. (Japan)
Inventor
  • Tomizawa, Kazuhito
  • Nagayoshi, Yu

Abstract

An object of the present invention is to provide a method for determining that a subject is at risk of suffering or is suffering from COVID-19. The present invention provides a method for determining whether a subject that is a mammal is at risk of suffering or suffering from COVID-19, the method including a step of detecting the amount of at least one modified nucleoside selected from the group consisting of 6-threonylcarbamoyl adenosine (t6A) and 2-thiomethyl,6-threonylcarbamoyl adenosine (ms2t6A) in a sample derived from the subject.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

11.

SPECTRUM ANALYSIS SYSTEM AND SPECTRUM ANALYSIS METHOD

      
Application Number 18518965
Status Pending
Filing Date 2023-11-25
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Fuji, Risa
  • Murakami, Sachio
  • Iwasaki, Shoko

Abstract

This spectrum analysis system has a measurer, a display, and a controller that displays plurality of first anomaly items that indicate the type of anomaly in appearance of the measurement spectrum waveform. The controller displays the first reference spectrum waveform for reference to a mode of appearance of the anomaly corresponding to each of the plurality of first anomaly items in the display.

IPC Classes  ?

12.

METHOD AND DEVICE FOR PROCESSING MASS SPECTROMETRY DATA

      
Application Number 18473700
Status Pending
Filing Date 2023-09-25
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kunimura, Yoshihiro
  • Uchiyama, Kosuke

Abstract

Provided is a method for processing mass spectrometry data by which the task of analyzing data of mass spectra acquired by a mass spectrometric analysis of an analysis target sample can be efficiently performed. The method includes the steps of: preparing data of a plurality of MS/MS spectra for each of one or more compounds contained in a sample, each of the MS/MS spectra acquired by an MS/MS scan measurement using each of a plurality of different precursor ions originating from the same compound (Steps 1-3); and creating data of a merged MS/MS spectrum for each of the one or more compounds by merging the data of the plurality of MS/MS spectra acquired by the MS/MS scan measurement using the plurality of precursor ions originating from the compound concerned (Step 6).

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes

13.

MASS SPECTROMETER AND MASS SPECTROMETRY METHOD

      
Application Number 18283605
Status Pending
Filing Date 2021-12-23
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Takahashi, Hidenori

Abstract

The precursor ion is reacted with ammonia molecules or ammonia radicals to generate product ions, the product ions are separated according to a mass-to-charge ratio, and detected. It is estimated that whether or not an aldehyde group is included in a molecular structure of the precursor ion based on a difference between a mass-to-charge ratio of one of the detected product ion and a mass-to-charge ratio of the precursor ion. In addition, provided is a mass spectrometer (1) including: a reaction chamber (132) to which the precursor ions are introduced; an ammonia supply part (5) configured to supply ammonia molecules or ammonia radicals to the reaction chamber; and separation and detection parts (142, 143, 144, and 145) configured to separate product ions generated from the precursor ion by reaction with the ammonia molecules or ammonia radicals according to a mass-to-charge ratio, and to detect the product ions.

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/02 - Particle spectrometers or separator tubes - Details
  • H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers

14.

ANALYSIS APPARATUS

      
Application Number 18522404
Status Pending
Filing Date 2023-11-29
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka, Hiroto

Abstract

An analysis apparatus according to this invention includes a measurer configured to measure a sample; a temperature adjuster configured to adjust a temperature of the sample during measurement; a display configured to display information: and a controller configured to control a function of displaying an interface on the display as the information, wherein the interface includes the followings: a plurality of items including temperature and time, and a graphic schematic diagram representing a thermal cycle with time and visualizing the plurality of items on the thermal cycle.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 1/28 - Preparing specimens for investigation
  • G06T 11/20 - Drawing from basic elements, e.g. lines or circles

15.

ANALYSIS SYSTEM

      
Application Number 18370275
Status Pending
Filing Date 2023-09-19
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Hinooka, Motomu

Abstract

The analysis system is provided with a placement member and an arm mechanism. The placement member has a positioning portion for defining a position of a sample container on a placement surface. The arm mechanism moves the sample container placed on the placement member to the positioning portion to thereby place the sample container at a reference position on the placement member.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

16.

METHOD FOR CREATING CALIBRATION CURVE AND METHOD FOR MEASURING AMYLOID ß-RELATED PEPTIDE

      
Application Number 18285134
Status Pending
Filing Date 2022-02-09
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor Kaneko, Naoki

Abstract

Included is the steps of providing a plurality of standard solutions containing amyloid β-related peptide and a surfactant and having different concentrations of the amyloid β-related peptide; mixing a solution containing internal standard peptide with each of the plurality of standard solutions; performing immunoprecipitation and mass spectrometry on a plurality of calibration curve solutions; standardizing signal intensity (A) in the amyloid β-related peptide with the signal intensity (B) in the internal standard peptide for each of the plurality of calibration curve solutions; and calculating a regression equation of a calibration curve based on a plurality of normalized intensities and the concentration of the amyloid β-related peptide.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 33/96 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard

17.

DATA ANALYSIS SYSTEM, ANALYSIS DATA DISPLAY APPARATUS AND DATA DISPLAY METHOD IN DATA ANALYSIS SYSTEM

      
Application Number 18516034
Status Pending
Filing Date 2023-11-21
First Publication Date 2024-05-30
Owner Shimadzu Corporation (Japan)
Inventor
  • Sawada, Ryuji
  • Ono, Takeshi

Abstract

A data analysis system according to this invention includes a data acquirer, a storage configured to store to-be-analyzed data items and analysis modules linked with top hierarchical data items, an analyzer, a display, and a controller configured to direct the display to display the to-be-analyzed data items and/or the analysis modules that are linked with the top hierarchical data item(s) whose access right (s) is/are provided to a user in the hierarchical structure, and to exclude the to-be-analyzed data items and the analysis modules that are linked with the top hierarchical data item(s) whose access right (s) is/are not provided to the user from items to be displayed on the display.

IPC Classes  ?

  • G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
  • G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
  • G06F 18/231 - Hierarchical techniques, i.e. dividing or merging pattern sets so as to obtain a dendrogram

18.

INFRARED RAMAN DEVICE

      
Application Number 18520342
Status Pending
Filing Date 2023-11-27
First Publication Date 2024-05-30
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Tao, Tomoyo
  • Sasayama, Tomoki
  • Shibutani, Ryuta
  • Otaguro, Atsuhiko
  • Katsutani, Fumiya

Abstract

An infrared Raman device is capable of switching and performing Raman measurement and first infrared measurement on a sample. The infrared Raman device includes an objective lens for Raman measurement; a first observation lens for infrared measurement; a laser light source that generates laser light; a first infrared light source that generates first infrared light; and a mirror. The mirror is disposed at time of the Raman measurement to reflect the laser light to cause the laser light to pass through the objective lens for Raman measurement and reflect Raman light generated from the sample by the laser light that passes through the objective lens for Raman measurement and radiated to the sample. The Raman light passes back through the objective lens for Raman measurement.

IPC Classes  ?

  • G01J 3/44 - Raman spectrometry; Scattering spectrometry
  • G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
  • G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry

19.

Display screen or portion thereof with graphical user interface of x-ray computed tomography device

      
Application Number 29845345
Grant Number D1029009
Status In Force
Filing Date 2022-07-06
First Publication Date 2024-05-28
Grant Date 2024-05-28
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Nakagawa, Hironobu
  • Matsumoto, Noriko
  • Harada, Daisuke
  • Keyaki, Yasuyuki
  • Kikuchi, Takahiro

20.

AROMA DESIGNER

      
Application Number 019031556
Status Pending
Filing Date 2024-05-24
Owner Shimadzu Corporation (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory gas chromatograph systems; gas chromatograph-mass spectrometers.

21.

AROMA DESIGNER

      
Serial Number 98567056
Status Pending
Filing Date 2024-05-24
Owner SHIMADZU CORPORATION (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Laboratory gas chromatograph systems, gas chromatograph-mass spectrometers

22.

Learning Data Creation Method and Learning Data Creation Device

      
Application Number 18282755
Status Pending
Filing Date 2021-10-05
First Publication Date 2024-05-23
Owner SHIMADZU CORPORATION (Japan)
Inventor Sakai, Takero

Abstract

The present disclosure provides a method for creating learning data to be used for creating a discriminator discriminating target samples having attributes different from each other.

IPC Classes  ?

23.

PUMP UNIT FOR CHROMATOGRAPH

      
Application Number 18384843
Status Pending
Filing Date 2023-10-28
First Publication Date 2024-05-16
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Fujiwara, Masanori
  • Nakamura, Takafumi
  • Iijima, Yuki
  • Wada, Kosuke

Abstract

A pump unit for a chromatograph includes a plunger pump and an upstream check valve. The plunger pump has a pump head and pumps a mobile phase. The upstream check valve is provided upstream of the pump head. The upstream check valve includes a flow-path portion and a temperature regulator. The flow-path portion guides the mobile phase to the plunger pump. The temperature regulator regulates a temperature of the mobile phase passing through the flow-path portion.

IPC Classes  ?

  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
  • G01N 30/20 - Injection using a sampling valve

24.

ANALYTE SPECIMEN ANALYSIS DEVICE, AND CALIBRATION CURVE GENERATION METHOD

      
Application Number JP2023039656
Publication Number 2024/101274
Status In Force
Filing Date 2023-11-02
Publication Date 2024-05-16
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sugiyama, Kiyohiro
  • Matsumoto, Junichi
  • Sudo, Tomokazu

Abstract

This analyte specimen analysis device (100) comprises: an analyte measurement unit (1) that measures an analyte specimen; a calibration curve generation unit (30) that, on the basis of measurement data (20) for the analyte specimen which was acquired by the analyte measurement unit, generates a calibration curve (21) to be used in an analysis of the analyte specimen; and a display unit (2) that displays at least a measurement condition (22a) of a blank specimen (90) which does not include a substance under investigation.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

25.

METHOD FOR MEASUREMENT OF NICOTINAMIDE MONONUCLEOTIDE (NMN) AND ITS RELATED METABOLITES

      
Application Number US2023079385
Publication Number 2024/103005
Status In Force
Filing Date 2023-11-10
Publication Date 2024-05-16
Owner
  • WASHINGTON UNIVERSITY (USA)
  • SHIMADZU CORPORATION (Japan)
Inventor
  • Imai, Shin-Ichiro
  • Unno, Junya
  • Ogura, Tairo
  • Nishimura, Masayuki

Abstract

The present disclosure is generally directed to methods and kits for measurement of nicotinamide mononucleotide (NMN) and its related metabolites in biological samples. The present disclosure is further directed to a method for calculating recovery efficiency of Nicotinamide mononucleotide (NMN) in a sample. The methods use a liquid chromatography-tandem mass spectrometry (LC-MS/MS)- driven methodology and double isotopic NMN standards. These methods and kits can be used for the study of nicotinamide adenine dinucleotide (NAD+) metabolism and aging.

IPC Classes  ?

26.

MASS SPECTROMETER

      
Application Number JP2023032730
Publication Number 2024/100977
Status In Force
Filing Date 2023-09-07
Publication Date 2024-05-16
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Terashima, Kenta
  • Kasamatsu, Satoshi

Abstract

Provided is a mass spectrometer (1) in which a first ion source (12) to (17) that atomizes a liquid sample under an atmospheric pressure to ionize the liquid sample and a second ion source (111) that emits laser beam to the sample to ionize the sample are attached alternatively as an ionization section, the mass spectrometer (1) being further provided with: a mass analysis section (231), (242) to (246) which is disposed in a vacuum chamber connected to the ionization section through a partitioning wall and separates and detects ions in accordance with mass-to-charge ratios thereof; a second ion introduction tube (31), (36) which is longer than a first ion introduction tube and is used when the second ion source is used, in which the first ion introduction tube is disposed through the partitioning wall and through which ions are introduced into the vacuum chamber and us used when the first ion source is used; and a heating section (37), (38) which heats a part of the second ion introduction tube which extends from the first ion introduction tube toward the ionization section side.

IPC Classes  ?

  • H01J 49/10 - Ion sources; Ion guns
  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

27.

Display screen or portion thereof with transitional graphical user interface of x-ray imaging device

      
Application Number 29843670
Grant Number D1026938
Status In Force
Filing Date 2022-06-23
First Publication Date 2024-05-14
Grant Date 2024-05-14
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Harada, Daisuke
  • Keyaki, Yasuyuki
  • Kikuchi, Takahiro
  • Matsumoto, Noriko
  • Nakagawa, Hironobu

28.

FLAME ATOMIC ABSORPTION PHOTOMETER

      
Application Number JP2023020679
Publication Number 2024/095514
Status In Force
Filing Date 2023-06-02
Publication Date 2024-05-10
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Iwai, Nobuyuki
  • Kobayashi, Tomoari
  • Kimoto, Takuya
  • Kobayashi, Osuke

Abstract

The present invention provides a flame atomic absorption photometer comprising: a burner 110 that forms a flame by burning a mixture of an atomized sample liquid and a mixed gas including a fuel gas and a combustion-assisting gas; flame light detection units 181, 182 that detect light radiated from the flame; and an expired flame determination unit 162 that determines that the flame has gone out when the intensity of the light detected by the flame light detection units is lower than a predetermined threshold value. The flame light detection units selectively detect light having a wavelength of 290 nm to 330 nm inclusive.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • F23N 5/08 - Systems for controlling combustion using devices responsive to thermal changes or to thermal expansion of a medium using light-sensitive elements
  • G01N 21/72 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using flame burners

29.

FLUORESCENT X-RAY ANALYSIS METHOD, ANALYSIS PROGRAM, AND FLUORESCENT X-RAY ANALYSIS DEVICE

      
Application Number JP2023028689
Publication Number 2024/095551
Status In Force
Filing Date 2023-08-07
Publication Date 2024-05-10
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Ogawa, Rie
  • Ochi, Hirotomo

Abstract

CRC/RC/R), which is the ratio of the measured intensity of the Rayleigh scattering line to the measured intensity of the Compton scattering line is obtained (S3). The thickness of the thin film and the contained amounts of respective elements constituting the target sample are determined by the fundamental parameter method on the basis of the measured scattering intensity ratio of the target sample (S5-S11).

IPC Classes  ?

  • G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence

30.

METHOD FOR ESTIMATING METABOLIC FLUX DISTRIBUTION, ANALYSIS DEVICE, AND PROGRAM

      
Application Number JP2023030109
Publication Number 2024/095564
Status In Force
Filing Date 2023-08-22
Publication Date 2024-05-10
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kusanagi, Toshihiro
  • Aisu, Ryota
  • Tagawa, Yusuke

Abstract

Provided is a method for estimating the metabolic flux distribution of cells, the method comprising: a step for acquiring discharge data including time-series data of a substance discharged to the outside of the cells with respect to a first strain cell and a second strain cell that is a reference for comparison; a step for calculating a discharge flux of the substance to the outside of the cells on the basis of the discharge data; a step for estimating a plurality of primary flux patterns on the basis of the discharge flux; and a step for clustering the plurality of primary flux patterns on the basis of the mutual similarity of the plurality of primary flux patterns and then outputting the clustered result.

IPC Classes  ?

  • G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

31.

IMAGING ANALYSIS DEVICE AND IMAGING DATA ANALYSIS METHOD

      
Application Number 17768404
Status Pending
Filing Date 2019-11-14
First Publication Date 2024-05-09
Owner SHIMADZU CORPORATION (Japan)
Inventor Yamaguchi, Shinichi

Abstract

An imaging analysis device according to the present invention includes: an analysis execution unit (1) configured to perform analysis by a predetermined analysis method for each of a plurality of measurement points set in a measurement area on a sample and collect imaging data; a reference image acquiring unit (2) configured to acquire a reference image for the measurement area; a regression analysis executer (36) configured to, with respect to the imaging data and the reference image obtained for the same sample, perform predetermined regression analysis calculation with the imaging data as an explanatory variable and data constituting the reference image as a target variable and acquire a regression model; and a predicted image creator (37) configured to apply, to the regression model, imaging data obtained by the analysis execution unit using a sample different from the sample used in the regression analysis executer, and create a predicted image based on a pseudo regression analysis result.

IPC Classes  ?

32.

ANALYSIS DEVICE

      
Application Number 18278616
Status Pending
Filing Date 2021-12-21
First Publication Date 2024-05-09
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Araki, Takahisa
  • Nagasao, Kota

Abstract

A driving part of an analysis device includes a cylindrical part on one surface of which a moving mirror is fixed, and a VCM connected at another surface of the cylindrical part and reciprocating the cylindrical part. The VCM includes: a yoke in a cylindrical shape; magnets provided at two ends of the yoke; a fixing part which is in a cylindrical shape enclosing the yoke and fixes, at a bottom surface, the yoke provided with the magnets; a lid part provided with windows and covering an opening surface of the fixing part; a moving part which is arranged between the yoke and the fixing part and on which a coil in a cylindrical shape is fixed; and support parts each including one end fixed to the moving part and another end connected at the another surface of the cylindrical part through the window.

IPC Classes  ?

33.

PREPARATIVE LIQUID CHROMATOGRAPH

      
Application Number 18279822
Status Pending
Filing Date 2021-11-08
First Publication Date 2024-05-09
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Tamaoki, Soichiro
  • Yamazaki, Tomoyuki
  • Sato, Shohei

Abstract

A separation channel on which a liquid delivery pump, a separation column, and a detector are provided, the liquid delivering pump being for feeding a mobile phase, the separation column being for separating a component in a sample, and the detector being for detecting peaks of components separated from each other by the separation column, a plurality of liquid handlers each including an injecting part and a collecting part, wherein when one of the plurality of liquid handlers is introduced into the separation channel, the injecting part of the one of the plurality of liquid handlers functions as an injector that executes injection operation of a sample into a mobile phase flowing through the analysis channel upstream of the separation column in the analysis channel and the collecting part of the one the plurality of liquid handlers functions as a fraction collector that executes collection operation of peaks of components separated from each other in the separation column, a selector for selectively switching a liquid handler to be introduced into the separation channel among a plurality of the liquid handlers, and a controller for controlling operation of a plurality of the liquid handlers and the selector.

IPC Classes  ?

34.

METHOD FOR MASS SPECTROMETRY AND CHROMATOGRAPH MASS SPECTROMETER

      
Application Number 18382398
Status Pending
Filing Date 2023-10-20
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Ueda, Manabu
  • Fujita, Shinjiro
  • Taniguchi, Junichi

Abstract

For a low-cost, high-accuracy tuning of the voltages applied to electrodes in a mass spectrometer, a chromatograph mass spectrometer (1) includes: a medium supplier (11) which supplies a medium as a mobile phase or carrier gas; a passage (15) which introduces, into the mass spectrometer, the medium supplied from the medium supplier; an ionizer (211) which ionizes the medium together with a substance coming from a member forming the passage into the medium; a measurement executer (25, 26, 43) which performs a mass separation and a measurement of a specific ion, using multiple measurement conditions which differ from each other in the value of voltage applied to at least one electrode included in one or more electrodes in the mass spectrometer; and a voltage value determiner (44) which determines the value of voltage applied to each electrode so that the intensity of the ion satisfies a predetermined criterion.

IPC Classes  ?

  • G01N 30/72 - Mass spectrometers
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

35.

MICRO-RAMAN DEVICE

      
Application Number 18382930
Status Pending
Filing Date 2023-10-23
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Shibutani, Ryuta

Abstract

A micro-Raman device includes a first laser light source, a second laser light source, a first holder, a second holder, a first ND filter, and a second ND filter. The first laser light source and the second laser light source generate first laser light of a first wavelength and second laser light of a second wavelength, respectively. The second wavelength is different from the first wavelength. The first laser light and the second laser light proceed in a second direction orthogonal to a first direction while being separated from each other in the first direction. The first holder and the second holder are arranged overlapping each other in the second direction.

IPC Classes  ?

36.

MASS SPECTROMETER

      
Application Number 18382955
Status Pending
Filing Date 2023-10-23
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Matsushita, Tomoyoshi

Abstract

Provided is a mass spectrometer including a vacuum chamber containing a cell used for causing ions originating from a sample to come in contact with a predetermined gas supplied from a gas supplier (20), which includes a three-way valve (204) configured to selectively send the gas into either a first passage (22) for sending the predetermined gas to the cell or a second passage (23) for discharging the gas into vacuum state. The mass spectrometer also includes a controller configured to control the three-way valve so as to send the gas into the second passage during an analysis period in which ions are not caused to come in contact with the gas within the cell and/or during a non-analyzing period, as well as to send the gas into the first passage during an analysis period in which ions are caused to come in contact with the gas within the cell.

IPC Classes  ?

  • H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
  • H01J 49/10 - Ion sources; Ion guns
  • H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures

37.

MASS SPECTROMETER AND METHOD FOR SETTING ANALYSIS CONDITION

      
Application Number 18383919
Status Pending
Filing Date 2023-10-26
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Matsushita, Tomoyoshi

Abstract

An ICP-MS includes a control device, a collision cell and a first electrode that are provided on an optical axis of plasma, and a second electrode, a mass separation device, and a detector that are provided on a detection axis. The control device sets, as an axis-shifting voltage to be applied to each electrode of the first electrode and the second electrode in a gas-present mode, the voltage obtained by adding an offset determined according to a mass-to-charge ratio of a target ion to an initial voltage in a gasless mode.

IPC Classes  ?

38.

MICRO-RAMAN APPARATUS AND METHOD FOR CONTROLLING MICRO-RAMAN APPARATUS

      
Application Number JP2023036490
Publication Number 2024/090177
Status In Force
Filing Date 2023-10-06
Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Furuta, Tetsuro
  • Fujiwara, Naoya
  • Moritani, Yuka

Abstract

A micro-Raman apparatus (100) comprises a light source unit (110), an objective lens unit (140), a detection device (160), a drive device (180), and a control device (200) for controlling the drive device (180). The light source unit (110) includes a plurality of light source devices (111-114) configured so as to generate mutually different wavelengths of light. The objective lens unit (140) condenses and radiates light from the light source unit (110) to a sample (SMP) to be analyzed. The detection device (160) detects Raman scattered light generated from the sample (SMP). The drive device (180) changes a relative distance between the sample (SMP) and the objective lens unit (140). The control device (200) is configured so as to correct the relative distance in accordance with the wavelength of light radiated from the light source device that is used.

IPC Classes  ?

39.

Infectious Disease Testing Method

      
Application Number 18279339
Status Pending
Filing Date 2021-06-18
First Publication Date 2024-05-02
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Yasojima, Makoto
  • Takemori, Hiroaki
  • Daigo, Fumi
  • Tomono, Takuya

Abstract

The present disclosure provides a test method for assessing the possibility of infection of residents without performing periodic PCR tests of residents of a facility in question. One embodiment is an infectious disease test method that includes a sampling step for collecting a sample from sewage during a sampling period in a route from where sewage is discharged from a facility until flowing into a public sewage pipe, an analysis step for analyzing the sample to obtain information relating to the existence of an infectious disease pathogen in the sample, and a notification step for notifying the facility of the information together with the sampling period.

IPC Classes  ?

  • G01N 1/20 - Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials

40.

ANALYZING METHOD FOR RNA

      
Application Number 18494008
Status Pending
Filing Date 2023-10-25
First Publication Date 2024-05-02
Owner Shimadzu Corporation (Japan)
Inventor Fukuyama, Yuko

Abstract

[OBJECT] To enable a more sensitive and uniform detection of a molecular-related ion in an analysis of an RNA contained in a sample by means of MALDI mass spectrometry. [OBJECT] To enable a more sensitive and uniform detection of a molecular-related ion in an analysis of an RNA contained in a sample by means of MALDI mass spectrometry. [MEANS FOR SOLVING PROBLEM] A mixed matrix containing 2,4-dihydroxyacetophenone (DHAP) and 2,4,6-trihydroxyacetophenone monohydrate (THAP) is used as a matrix to analyze an RNA contained in a sample by a matrix-assisted laser desorption/ionization mass spectrometer.

IPC Classes  ?

  • C12Q 1/6872 - Methods for sequencing involving mass spectrometry
  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

41.

GAS CHROMATOGRAPH ASSISTANCE DEVICE AND GAS CHROMATOGRAPH ASSISTANCE METHOD

      
Application Number 18378558
Status Pending
Filing Date 2023-10-10
First Publication Date 2024-04-18
Owner Shimadzu Corporation (Japan)
Inventor Fukushima, Daiki

Abstract

A GC assistance device includes a saving amount evaluator, a consumption amount evaluator and an outputter, and is used together with a gas chromatograph. The saving amount evaluator evaluates a saving amount of a resource caused by stopping of the gas chromatograph. The consumption amount evaluator evaluates a consumption amount of the resource caused by recovery of the gas chromatograph from a stop state. The outputter presents an evaluation value in regard to the saving amount and the consumption amount to a user. Alternatively, the outputter controls an operation state of the gas chromatograph based on the evaluation value.

IPC Classes  ?

  • G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

42.

FLOW RATE SWITCHING MECHANISM AND MASS SPECTROMETER

      
Application Number 18485311
Status Pending
Filing Date 2023-10-12
First Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Shiba, Shunki
  • Matsushita, Tomoyoshi

Abstract

A flow rate switching mechanism including: a first section including: a first housing with a passage internally bored through, the passage having a narrowed portion at a distance from one end of the passage, and the narrowed portion having a smaller cross-sectional area than the cross-sectional area of the passage at the one end; a capillary having an internal passage having a smaller cross-sectional area than the cross-sectional area of the narrowed portion; and a hermetic support member supporting the capillary and to provide a seal; a second section having a second housing identical in shape to the first housing, without having the capillary and the hermetic support member; and a three-way valve being alternatively switchable between a first state in which the outlet end is connected to the first inlet end and a second state in which the outlet end is connected to the second inlet end.

IPC Classes  ?

  • H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures
  • F25B 41/42 - Arrangements for diverging or converging flows, e.g. branch lines or junctions
  • H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

43.

TREATMENT DEVICE

      
Application Number JP2022038157
Publication Number 2024/079837
Status In Force
Filing Date 2022-10-13
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Ikezawa, Yoshio

Abstract

A treatment device (1) is provided with: a vessel (50) for containing a sample; pipes (11-13) for introducing, into the vessel, a treatment liquid for decomposing an impurity contained in the sample; a port (64) that discharges, from the vessel containing the sample, a liquid contained in the sample as waste liquid; a pump (33) connected to the port; and a control device (500) for controlling the pump. The control device controls the pump so as to enable a predetermined amount or more of the waste liquid to be discharged from the port.

IPC Classes  ?

  • G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting
  • B03D 1/14 - Flotation machines

44.

DIAGNOSIS SUPPORT METHOD, DIAGNOSIS SUPPORT PROGRAM, AND DIAGNOSIS SUPPORT SYSTEM

      
Application Number JP2023026093
Publication Number 2024/079957
Status In Force
Filing Date 2023-07-14
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Hirose, Ryuta
  • Hasegawa, Yukinori
  • Nakaya, Tomohiro
  • Uno, Haruo
  • Oyama, Shintaro
  • Nakagawa, Yasunobu
  • Yagi, Tetsuya
  • Iguchi, Mitsutaka

Abstract

Provided is a diagnosis support system that acquires one or more items of patient information associated with a patient (steps S30, S40), and inputs the one or more items into an estimation model and acquires, from a plurality of diseases, a candidate for a disease that the patient may have (step S50). The diagnosis support system then acquires additional required information to be additionally acquired from the patient on the basis of the candidate for the disease (step S70). The diagnosis support system then presents the additional required information (step S90).

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

45.

QUALITY CONTROL STANDARD SOLUTION USED IN PEPTIDE ASSAY, AND QUALITY CONTROL OF PEPTIDE ASSAY

      
Application Number 18278094
Status Pending
Filing Date 2022-02-02
First Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Yoda, Ritsuko

Abstract

A quality control standard for peptide (including protein) measurement, and a quality control for peptide (including proteins) measurement are provided. A QC standard sample for measurement of a target peptide, the QC standard sample comprising: a blood sample comprising a peptide, and a peptide labeled with a stable isotope that is spiked into said blood sample. The target peptide to be measured includes, for example, at least one selected from the group consisting of Aβ1-42 (SEQ ID NO.: 9), Aβ1-38 (SEQ ID NO.: 11), Aβ1-40 (SEQ ID NO.: 7), and APP669-711 (SEQ ID NO.: 10). The peptide labeled with a stable isotope that is spiked into the blood sample includes, for example, at least one selected from the group consisting of SIL-Aβ1-42, SIL-Aβ1-38, SIL-Aβ1-40, and SIL-APP669-711.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • G01N 30/02 - Column chromatography
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

46.

RECOVERY IMPLEMENT AND RECOVERY SYSTEM

      
Application Number JP2022038155
Publication Number 2024/079835
Status In Force
Filing Date 2022-10-13
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Ikezawa, Yoshio

Abstract

This recovery implement (100) recovers subject material contained in a discharged liquid that is discharged from each of a plurality of treatment devices (1A, 1B, 1C) for treating samples. The recovery implement comprises: a plurality of filtration units (110A, 110B, 110C) that are provided corresponding to the plurality of treatment devices, the filtration units filtering the discharged liquid that is discharged from the corresponding treatment devices and extracting the subject material contained in the discharged liquid; a holder (101) that integrally accommodates the plurality of filtration units; and a discharge unit (102) that discharges a waste liquid that has passed through each of the plurality of filtration units. The holder can be detached from the discharge unit together with the plurality of filtration units in which the subject material resides.

IPC Classes  ?

  • B01D 29/90 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ;   Filtering elements therefor having feed or discharge devices for feeding
  • B01D 29/01 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ;   Filtering elements therefor with flat filtering elements
  • G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting

47.

PROCESSING DEVICE, PROCESSING METHOD, AND CONTROL PROGRAM

      
Application Number JP2022038156
Publication Number 2024/079836
Status In Force
Filing Date 2022-10-13
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor Ikezawa, Yoshio

Abstract

A processing device (1) comprises: a container (50) that accommodates a specimen; a control device (500) that extracts a target substance from the specimen accommodated in the container; and an input device (505) that receives input from a user. The control device performs a refresh process in which a first processing liquid for processing a contaminant included in the specimen is introduced into the container in which the specimen is accommodated, and after the first processing liquid has been introduced, on the basis of an input to the input device, a second processing liquid for re-processing the contaminant included in the specimen is introduced into the container.

IPC Classes  ?

  • G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting
  • B03D 1/14 - Flotation machines

48.

METHOD FOR FILLING HEAT TRANSPORT DEVICE WITH REFRIGERANT AND REFRIGERANT FILLING CONTROL DEVICE FOR HEAT TRANSPORT DEVICE

      
Application Number JP2023036301
Publication Number 2024/080213
Status In Force
Filing Date 2023-10-05
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sekimoto, Shunsuke
  • Horiguchi, Yukio
  • Matsuda, Shotaro
  • Nishiura, Yoshiaki

Abstract

This method for filling a heat transport device (110) with a refrigerant comprises: a pre-filling step (step 902) for filling a refrigerant flow path (10) of a heat transport device (110) with an inactive gas such that the pressure inside the refrigerant flow path (10) of the heat transport device (110) reaches a prescribed pressure; and a main filling step (step 904) for filling the refrigerant flow path (10) of the heat transport device (110) with a refrigerant to a prescribed quantity necessary for operating the heat transport device (110), after the pre-filling step (step 902).

IPC Classes  ?

  • F25B 45/00 - Arrangements for charging or discharging refrigerant
  • F25B 1/00 - Compression machines, plants or systems with non-reversible cycle
  • F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes

49.

FLOW PATH STATE OUTPUT DEVICE

      
Application Number JP2023036580
Publication Number 2024/080246
Status In Force
Filing Date 2023-10-06
Publication Date 2024-04-18
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Shimizu, Satoshi
  • Morita, Daisuke

Abstract

A computer according to an embodiment of this flow path state output device is connected to a liquid chromatograph and obtains the result of analysis processing performed by the liquid chromatograph. The computer comprises a feature amount acquisition unit and a state output unit. The feature amount acquisition unit measures a sample containing a known component by means of an analysis device, and obtains a feature amount from the measurement result. The state output unit outputs the flow path state of the liquid chromatograph to a display on the basis of the feature amount.

IPC Classes  ?

  • G01N 30/86 - Signal analysis
  • G01N 30/26 - Conditioning of the fluid carrier; Flow patterns
  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed

50.

ELEM-SPOT

      
Application Number 019012917
Status Pending
Filing Date 2024-04-12
Owner Shimadzu Corporation (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Gas Chromatograph; Mass Spectrometer with an element-selective combustion unit included for selectively analyzing nitrogen-containing compounds or oxygenated compounds in complex hydrocarbon compounds with high sensitivity.

51.

TIME-OF-FLIGHT MASS SPECTROMETRY DEVICE AND ANALYSIS METHOD

      
Application Number 17768747
Status Pending
Filing Date 2020-08-17
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kishida, Takuro
  • Aoki, Yasushi
  • Kawai, Toshitaka

Abstract

A time-of-flight mass spectrometry device includes an electrode to which a DC high voltage is applied in order to form an ion flight space and a high voltage power supply device that applies the high voltage to the electrode. The high voltage power supply device includes a high voltage generating circuit that generates the high voltage, and a voltage control circuit that is selectively set to a convergence responsiveness priority mode in which the high voltage generating circuit is controlled such that the high voltage has first convergence responsiveness and first stability or a stability priority mode in which the high voltage generating circuit is controlled such that the high voltage has second convergence responsiveness that is lower than the first convergence responsiveness and second stability that is higher than the first stability.

IPC Classes  ?

  • H01J 49/40 - Time-of-flight spectrometers
  • H01J 49/02 - Particle spectrometers or separator tubes - Details

52.

AIR MEASUREMENT METHOD USING GAS CHROMATOGRAPH AND GAS CHROMATOGRAPH ANALYSIS SYSTEM

      
Application Number 18276858
Status Pending
Filing Date 2021-09-22
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Uchiyama, Shinji

Abstract

An air measurement method of performing measurement by injecting air into a gas chromatograph includes a liquid suction step of sucking a liquid that does not interfere with detection of a predetermined component in air by a gas chromatograph into a syringe to fill the syringe with the liquid, an air suction step of sucking a predetermined amount of air into the syringe after the liquid suction step, an injection step of injecting the predetermined amount of air sucked into the syringe into the gas chromatograph after the air suction step, and a recording step of acquiring a detection signal for the air injected into the gas chromatograph in the injection step and recording an acquired detection signal in association with the air injection amount into the gas chromatograph.

IPC Classes  ?

  • G01N 30/18 - Injection using a septum or microsyringe

53.

ELEM-SPOT

      
Serial Number 98495847
Status Pending
Filing Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Gas chromatograph mass spectrometer with an element-selective combustion unit included for selectively analyzing nitrogen-containing compounds or oxygenated compounds in complex hydrocarbon compounds with high sensitivity

54.

METHOD FOR ANALYZING DATA ACQUIRED BY MALDI MASS SPECTROMETRY, DATA-PROCESSING DEVICE, MASS SPECTROMETER, AND DATA-ANALYZING PROGRAM

      
Application Number 17960609
Status Pending
Filing Date 2022-10-05
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor Teramoto, Kanae

Abstract

A method for analyzing MALDI mass spectrometry data includes: calculating m/z values respectively corresponding to peaks in amass spectrum, from data corresponding to the mass spectrum acquired by MALDI mass spectrometry performed on a sample; and performing at least one of calculations (a) and (b), based on the m/z values and information on kinds of ions possibly generated from the sample in the mass spectrometry, where calculation (a) includes assuming that ions respectively corresponding to the peaks are first ions singly charged, and calculating m/z of second ions respectively corresponding to the first ions and being multiply charged, and calculation (b) includes assuming that ions respectively corresponding to the peaks are first ions that are multiply charged ions, and calculating m/z of second ions respectively corresponding to the first ions and being singly charged.

IPC Classes  ?

  • H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/40 - Time-of-flight spectrometers

55.

Estimation Device, Learning Device, Optimization Device, Estimation Method, Learning Method, and Optimization Method

      
Application Number 18275969
Status Pending
Filing Date 2022-01-31
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Suzuki, Takashi
  • Yamamoto, Shuhei
  • Toyoda, Kenichi
  • Kuroda, Hirotaka

Abstract

An estimation device (200) generates quality prediction data (540) indicating a quality of a drug substance of a biopharmaceutical manufactured by culturing cells, by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance in a culturing vessel at least one timing after a predetermined time period has passed since the cells have been seeded in a medium. The prediction model (420) is generated by executing a learning process using training data (530) that includes measurement data including a measurement result obtained by measuring a substance in a culturing vessel at a plurality of timings after seeding of the cells in the medium, and quality data obtained by analyzing a drug substance of the biopharmaceutical manufactured from the cells.

IPC Classes  ?

  • G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G16C 20/70 - Machine learning, data mining or chemometrics
  • G16C 20/80 - Data visualisation

56.

BIOCHEMICAL ANALYSIS APPARATUS AND BIOCHEMICAL ANALYSIS METHOD

      
Application Number 18388745
Status Pending
Filing Date 2023-11-10
First Publication Date 2024-04-11
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Onoki, Takanori
  • Sugiyama, Kiyohiro

Abstract

A biochemical analysis apparatus includes a piercer for piercing a cover member, a nozzle that passes through the piercer which has pierced the cover member and suctions a specimen, a liquid surface sensor that detects contact of the nozzle with the specimen, and a controller that drives the nozzle and the piercer, in which the controller provides an error notification upon detection of contact of the nozzle with the accommodation object inside the piercer, and upon detection of a collision of the nozzle with the cover member.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

57.

METHOD AND DEVICE FOR SUGGESTING POSITIONING OF ELECTROMAGNETIC SENSORS, AND CURRENT SOURCE LOCATION ESTIMATION METHOD

      
Application Number JP2023035835
Publication Number 2024/075669
Status In Force
Filing Date 2023-10-02
Publication Date 2024-04-11
Owner
  • SHIMADZU CORPORATION (Japan)
  • RIKEN (Japan)
Inventor
  • Gomi, Tomohiro
  • Tomita, Sadamu
  • Umebayashi, Ryu
  • Yamashita, Okito
  • Takeda, Yusuke

Abstract

This method for suggesting the positioning of electromagnetic sensors involves suggesting the positioning of a plurality of electromagnetic sensors positioned on the surface of a living body around a target region inside a subject, using a forward model for estimating electromagnetic fields produced at the positions of the plurality of electromagnetic sensors by biological activity inside the subject, the method including: a step for setting calculation conditions including the position of the target region and the positions at which the plurality of electromagnetic sensors can be positioned; a step for calculating, on the basis of the calculation conditions that have been set, suggested positioning for all or some of the plurality of electromagnetic sensors, which are for estimating the position of a current source inside the subject; and a step for outputting the suggested positioning.

IPC Classes  ?

  • A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents

58.

CALIBRANT FOR USE IN MASS SPECTROMETER AND METHOD FOR PRODUCING SAME

      
Application Number 18276323
Status Pending
Filing Date 2022-02-02
First Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Nishikaze, Takashi
  • Kaneko, Naoki

Abstract

A calibrant for use in correction of machine difference of mass spectrometers and a method for producing the calibrant are provided. A calibrant for use in a mass spectrometer, the calibrant comprising not less than two calibration substances, wherein a ratio of, relative to a concentration of one calibration substance of the not less than two calibration substances, a concentration of another calibration substance of the not less than two calibration substances is a predetermined value, and a method for producing the calibrant.

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes

59.

ANALYSIS SYSTEM

      
Application Number JP2023016614
Publication Number 2024/070027
Status In Force
Filing Date 2023-04-27
Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Yonekura Takuya

Abstract

An analysis system (1) comprises an analysis device (100) that analyzes samples. At least one of the constituent elements of the analysis device (100) is a temperature adjustment constituent element (106; 108) that includes a temperature adjustment element (112; 116) and a temperature sensor (112; 116). The temperature adjustment constituent element (106; 108) must perform temperature control by using the temperature adjustment element (112, 116) and the temperature sensor (112, 116) and stabilize the temperature at a set target temperature at the time of starting the analysis. The analysis device (100) enters an analysis-enabled state in which analysis can be started when the temperatures of all the temperature adjustment constituent elements (106; 108) stabilize at the temperature set for each. The analysis system (1) comprises: a time measurement unit (202) that is configured to measure, as stabilization times, the time required from the start of the temperature control until output of the temperature sensor (112; 116) stabilizes, every time the temperature control is executed; a data accumulation unit (204) that is configured to store and accumulate the stabilization times, which are measured by the time measurement unit (202) each time the temperature control is executed, in association with conditions that affect the stabilization times when the temperature control is executed; and a time prediction unit (206) that is configured to calculate a predicted value of the time required for the analysis device (100) to enter the analysis-enabled state, by using a large number of compatible stabilization times, from among the stabilization times accumulated by the data accumulation unit (204), in which the associated conditions are compatible with the conditions at the time of the setting, when the settings for the analysis are made.

IPC Classes  ?

60.

MASS SPECTROMETER AND POWER SUPPLY DEVICE

      
Application Number 18447640
Status Pending
Filing Date 2023-08-10
First Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Mizutani, Shiro

Abstract

A power supply device applies a voltage to a quadrupole mass filter. The power supply device has a main substrate and a wave-detection substrate. The main substrate includes a detector. The wave-detection substrate includes a wave detector and an identifier. The wave detector detects an AC component of a voltage to be applied to the quadrupole mass filter as a wave-detection voltage. The identifier outputs identification information of the wave detector defined in correspondence with the configuration of a rectifying device of the wave detector. The detector detects identification information output by the identifier, and supplies the detected identification information to a corrector that corrects a deviation of voltage caused by a leakage current of the rectifying device.

IPC Classes  ?

  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/02 - Particle spectrometers or separator tubes - Details
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

61.

X-RAY PHASE IMAGING DEVICE AND X-RAY PHASE IMAGING ANALYSIS METHOD

      
Application Number JP2023028534
Publication Number 2024/070230
Status In Force
Filing Date 2023-08-04
Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Doki, Takahiro
  • Kimura, Kenji
  • Morimoto, Naoki
  • Nagai, Ishikawa, Lisa

Abstract

This X-ray phase imaging device (100) comprises: an X-ray light source (10), an X-ray detector (11), a plurality of lattices; a rotary mechanism (15) which rotates a subject (90) including fibers (91a) and the plurality of lattices relative to each other; an image processing unit (2a) which generates a plurality of X-ray phase contrast images (40) for each of the orientations of the subject with respect to the plurality of lattices; and a control unit (2b) which acquires orientation information (30) pertaining to the orientations of fibers included in the subject on the basis of the plurality of X-ray phase contrast images, and acquires a feature amount (31) pertaining to the mechanical strength of the subject.

IPC Classes  ?

  • G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers

62.

OPTIMIZATION METHOD FOR WORK SYSTEM, AND CONTROL SYSTEM

      
Application Number JP2023029396
Publication Number 2024/070282
Status In Force
Filing Date 2023-08-14
Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Kurata, Seiya

Abstract

According to the present invention, a management device optimizes a work system. More specifically, this management device: sets a control parameter set that is made up of one or more parameters for controlling actions of the work system (step S10); controls the actions of the work system on the basis of the control parameter set (step S12); acquires an observation value relating to the work system in relation to execution of the actions based on the control parameter set (step S14); calculates a posterior distribution of a model function in which one or more parameters are variables by using the control parameter set and the observation value (step S20); and updates an optimization function for identifying an optimal parameter set as the control parameter set, using calculation results of the posterior distribution (step S24).

IPC Classes  ?

  • G06N 99/00 - Subject matter not provided for in other groups of this subclass

63.

TEST SCHEDULE MANAGEMENT METHOD AND MANAGEMENT DEVICE, AND TEST SCHEDULE MANAGEMENT PROGRAM

      
Application Number JP2023029399
Publication Number 2024/070283
Status In Force
Filing Date 2023-08-14
Publication Date 2024-04-04
Owner SHIMADZU CORPORATION (Japan)
Inventor Nimura, Risa

Abstract

Provided is a management method for a test schedule that includes a first step and a second step. The time slots for the first step include time slots for which work on the part of a worker is not required, and the time slots for the second step include time slots for which work on the part of a worker is required. When the second step is arranged in a portion of the first step in a test schedule, the second step is arranged in the test schedule such that time slots in the second step for which work on the part of a worker is required overlap only time slots in the first step for which work on the part of a worker is not required.

IPC Classes  ?

  • G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
  • G06Q 10/1093 - Calendar-based scheduling for persons or groups

64.

Mass spectrometer

      
Application Number 29815635
Grant Number D1020502
Status In Force
Filing Date 2021-11-16
First Publication Date 2024-04-02
Grant Date 2024-04-02
Owner SHIMADZU CORPORATION (Japan)
Inventor Kang, Hyeri

65.

MASS SPECTROMETER

      
Application Number 17768929
Status Pending
Filing Date 2020-08-11
First Publication Date 2024-03-28
Owner SHIMADZU CORPORATION (Japan)
Inventor Hosoo, Kohei

Abstract

A mass spectrometer includes: a first ion guide disposed in a first intermediate vacuum chamber; a first partition wall portion which constitutes at least a part of a partition wall separating the first intermediate vacuum chamber and a second intermediate vacuum chamber and has an ion passage hole; a second ion guide disposed in a second intermediate vacuum chamber; a second partition wall portion which constitutes at least a part of a partition wall which is a subsequent stage of the second intermediate vacuum chamber and has an ion passage hole; a first holding portion configured to integrally hold the first ion guide and the first partition wall portion; a second holding portion configured to hold the second ion guide; a coupling portion detachably connecting the first holding portion and the second holding portion; and a vacuum chamber main body portion to which an ion transport unit is detachably mounted.

IPC Classes  ?

  • H01J 49/06 - Electron- or ion-optical arrangements
  • H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures

66.

X-RAY PHASE IMAGING APPARATUS AND DISPLAY METHOD OF PREVIEW IMAGE IN X-RAY PHASE IMAGING APPARATUS

      
Application Number 18355557
Status Pending
Filing Date 2023-07-20
First Publication Date 2024-03-28
Owner Shimadzu Corporation (Japan)
Inventor
  • Kojima, Kana
  • Maeda, Yuto
  • Doki, Takahiro

Abstract

An X-ray phase imaging apparatus includes an X-ray source; a detector; a plurality of gratings; a rotation mechanism; an image processor configured to generate a phase contrast image and to generate a preview image prior to capture of the phase contrast image; and a controller configured to control function of displaying on a display the preview image, and function of discriminatively displaying on the display an image coverage area for the phase contrast image that is associated with a relative rotation angle between the plurality of gratings and a subject.

IPC Classes  ?

  • G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers
  • G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
  • G01N 23/201 - Measuring small-angle scattering, e.g. small angle X-ray scattering [SAXS]

67.

X-RAY PHASE IMAGING APPARATUS AND X-RAY PHASE IMAGING METHOD

      
Application Number 18363168
Status Pending
Filing Date 2023-08-01
First Publication Date 2024-03-28
Owner Shimadzu Corporation (Japan)
Inventor
  • Kojima, Kana
  • Maeda, Yuto

Abstract

An X-ray phase imaging apparatus includes a control device configured or programmed to make a notification prompting a user to update or generate a corresponding second X-ray image when determining that a decrease in an image quality of an X-ray phase contrast image generated based on a first X-ray image obtained by imaging a subject and a second X-ray image obtained by imaging without the subject arranged does not fall within a predetermined allowable range and/or determining that the second X-ray image associated with an imaging condition has not been stored.

IPC Classes  ?

  • G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers
  • G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays

68.

DIFFERENTIAL ION MOBILITY SPECTROMETRY

      
Application Number EP2022076483
Publication Number 2024/061469
Status In Force
Filing Date 2022-09-23
Publication Date 2024-03-28
Owner
  • SHIMADZU CORPORATION (Japan)
  • SHIMADZU RESEARCH LABORATORY (EUROPE) LTD (United Kingdom)
Inventor
  • Andrzejewski, Roch
  • Giles, Roger

Abstract

EDD TPNTPRREDD NTPRR, is compared to a pre-set target ratio value and, if the comparison reveals a difference therebetween, an adjusted value of the dispersion electric field sufficient reduce the difference is applied across the analytical gap.

IPC Classes  ?

  • G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
  • G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry

69.

MASS SPECTROMETRY METHOD AND MASS SPECTROMETER

      
Application Number 17767946
Status Pending
Filing Date 2019-11-11
First Publication Date 2024-03-28
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Takahashi, Hidenori
  • Sekiya, Sadanori
  • Yamauchi, Shosei

Abstract

First product ion spectrum data is acquired by dissociating a precursor ion derived from a sample component by collision between the precursor ion and an inert gas molecule to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; second product ion spectrum data is acquired by dissociating the precursor ion by a reaction of the precursor ion with hydrogen radicals to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; and a set of product ions having a predetermined mass difference is extracted in the first product ion spectrum data and the second product ion spectrum data.

IPC Classes  ?

  • G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
  • H01J 49/26 - Mass spectrometers or separator tubes

70.

GAS CHROMATOGRAPH AND CARRIER GAS USAGE AMOUNT DISPLAY METHOD

      
Application Number 18354013
Status Pending
Filing Date 2023-07-18
First Publication Date 2024-03-28
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Sakamoto, Yuki
  • Nagao, Yu

Abstract

A gas chromatograph includes a sample gas generator, a separation column configured to separate components of an introduced sample gas, a gas supply source configured to supply a carrier gas to the sample gas generator to carry the sample gas from the sample gas generator to the separation column when the components of the sample gas are analyzed, a controller configured or programmed to acquire an in-analysis usage amount of the carrier gas based on an analysis time for analyzing the components of the sample gas, and a flow rate of the carrier gas supplied from the gas supply source to the sample gas generator, and a display configured to display the in-analysis usage amount acquired by the controller.

IPC Classes  ?

  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed

71.

X-RAY PHASE IMAGING APPARATUS AND DISPLAY METHOD OF PREVIEW IMAGE IN X-RAY PHASE IMAGING APPARATUS

      
Application Number 18357287
Status Pending
Filing Date 2023-07-24
First Publication Date 2024-03-28
Owner Shimadzu Corporation (Japan)
Inventor
  • Maeda, Yuto
  • Kojima, Kana

Abstract

An X-ray phase imaging apparatus includes an X-ray source; a detector; a plurality of gratings; an image processor configured to generate two or more types of first phase contrast images selected from absorption, differential phase and dark-field images as preview images under an imaging condition simpler than an imaging condition for a second phase contrast image to be captured in actual imaging; and a controller configured to display the first phase contrast images on a display.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

72.

DIFFERENTIAL ION MOBILITY ANALYSIS

      
Application Number EP2022076480
Publication Number 2024/061468
Status In Force
Filing Date 2022-09-23
Publication Date 2024-03-28
Owner
  • SHIMADZU CORPORATION (Japan)
  • SHIMADZU RESEARCH LABORATORY (EUROPE) LTD (United Kingdom)
Inventor
  • Andrzejewski, Roch
  • Giles, Roger
  • Entwistle, Andrew

Abstract

A method of analyzing ions comprising generating ions from a sample in an ion source, delivering them into a vacuum region of a vacuum enclosure comprising an ion mobility analyser having an ion drift region formed between opposing electrodes defining an analytical gap. The ions emerge from the ion inlet as a supersonic jet of a buffer gas within which the ions are entrained to enter the drift region and, e.g., priorto mass spectral analysis of the ions in a downstream vacuum region, conducting differential ion mobility analysis of the ions in the first vacuum region. Priorto conducting differential ion mobility analysis (e.g., and mass spectral analysis) according of the ion, the method comprises a) changing a rate of flow of gas into or out of the vacuum region; b) measuring a gas pressure in the vacuum region and repeating steps a) and b) until a target gas pressure value is achieved; c) measuring a velocity of gas flow along the drift region and repeating steps a) to c) until the measured gas velocity value has achieved a pre-set target gas velocity value and subsequently conducting said differential ion mobility analysis and said mass spectral analysis according to said target gas pressure value and said target gas velocity value.

IPC Classes  ?

  • G01N 27/624 - Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
  • G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry

73.

DEBINDING RECIPE SETTING METHOD

      
Application Number JP2023025007
Publication Number 2024/062731
Status In Force
Filing Date 2023-07-05
Publication Date 2024-03-28
Owner SHIMADZU CORPORATION (Japan)
Inventor Tanaka, Suguru

Abstract

The present invention is capable of setting a debinding recipe with low power consumption and in a short period of time, and minimizes time consumption and energy loss in an actual debinding treatment performed according to the set recipe. The present invention performs: a data accumulation step for associating existing treatment target analysis data that is obtained by using a differential thermal measurement device, a thermogravimetry device, and/or a thermomechanical analysis device to analyze part of an existing treatment target with debinding result data that indicates the result of debinding the existing treatment target in a debinding furnace, and for accumulating the data in a memory; an analysis step for analyzing, on the basis of the existing treatment target analysis data and the debinding result data which are accumulated in a data accumulation unit, new treatment target analysis data that is obtained by using the differential thermal measurement device, the thermogravimetry device, and/or the thermomechanical analysis device 300 to analyze part of a new treatment target; and a recipe setting step for setting a debinding recipe for the new treatment target on the basis of the analysis result in the analysis step.

IPC Classes  ?

  • C04B 35/638 - Removal thereof
  • B28B 11/00 - Apparatus or processes for treating or working the shaped articles
  • G01N 25/20 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity

74.

Total organic carbon meter

      
Application Number 29758221
Grant Number D1019441
Status In Force
Filing Date 2020-11-13
First Publication Date 2024-03-26
Grant Date 2024-03-26
Owner SHIMADZU CORPORATION (Japan)
Inventor Hasebe, Shinya

75.

SIGNAL PROCESSING DEVICE FOR X-RAY ANALYSIS

      
Application Number 18274611
Status Pending
Filing Date 2021-07-29
First Publication Date 2024-03-21
Owner SHIMADZU CORPORATION (Japan)
Inventor Saito, Yuta

Abstract

Provided is a signal processing device for X-ray analysis capable of suppressing effects of increased background due to pile-up signals and suppressing the dead time from lengthening. A signal processing device for X-ray analysis includes a differentiating circuit configured to convert a plurality of staircase wave signals detected by the X-ray detector into differential wave signals, a digital filter configured to convert the differential wave signals into trapezoidal wave signals or triangular wave digital signals, and a peak detection unit configured to discriminate and count a peak value extracted from a peak portion of the trapezoidal wave signal or the triangular wave signal. The peak detection unit is set such that a rising threshold Tu to be compared with a signal of the rising-side sloped line segment and a falling threshold Td to be compared with a signal of the falling-side sloped line segment in the trapezoidal signal or the triangular wave signal have a relation of Tu>Td. The peak detection unit selects the trapezoidal signal or the triangular wave signal to be counted from the converted trapezoidal signal or the converted triangular wave signal based on the rising threshold Tu, and terminates detection of the peak portion of the trapezoidal signal or the triangular wave signal based on the falling threshold Td.

IPC Classes  ?

  • G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence

76.

Raman Infrared Compound Microscope Device

      
Application Number 18214507
Status Pending
Filing Date 2023-06-26
First Publication Date 2024-03-21
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Katsutani, Fumiya
  • Sasayama, Tomoki
  • Tao, Tomoyo
  • Otaguro, Atsuhiko
  • Shibutani, Ryuta
  • Fukuda, Hisato

Abstract

A Raman infrared compound microscope device includes: a first light source that generates laser light; a second light source that generates infrared light; a third light source that generates visible light; and a first optical system. The first optical system orients the visible light having reached the first optical system in different directions between when performing a Raman analysis using Raman light generated from a sample by irradiation of the laser light and when performing a first infrared analysis using the infrared light having passed through the sample.

IPC Classes  ?

  • G01N 21/65 - Raman scattering
  • G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
  • G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
  • G01J 3/44 - Raman spectrometry; Scattering spectrometry
  • G02B 21/06 - Means for illuminating specimen

77.

METHOD FOR MASS SPECTROMETRY OF ORGANIC SYNTHETIC COMPOUND

      
Application Number 18271386
Status Pending
Filing Date 2021-09-22
First Publication Date 2024-03-21
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Shima, Keisuke
  • Fukuyama, Yuko

Abstract

The present invention provides a method for mass spectrometry of a negatively charged organic synthetic compound, and a matrix that can be used in said method. A method for mass spectrometry of a negatively charged organic synthetic compound, the method comprising using, as a liquid matrix, an ionic liquid comprising an amine ion and an acidic group-containing organic substance ion. For example, the amine is 3-aminoquinoline (3-AQ), and the acidic group-containing organic substance is p-coumaric acid (p-CA). The negatively charged organic synthetic compound to be analyzed is, for example, an organic synthetic polymer compound or a complex compound.

IPC Classes  ?

  • H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
  • G01N 30/84 - Preparation of the fraction to be distributed

78.

METHOD FOR CONTROLLING MOBILE OBJECT, TRANSPORT DEVICE, AND WORK SYSTEM

      
Application Number JP2023029395
Publication Number 2024/057800
Status In Force
Filing Date 2023-08-14
Publication Date 2024-03-21
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Imai, Shinji
  • Takahara, Kazuma

Abstract

A management device (100) performs, as a method for controlling a mobile object: a step for generating a machine learning model for generating an operation plan for a mobile object for transporting an object, on the basis of the position of a first feature portion in a simulation space; a step for identifying the position of a second feature portion in the real space; a step for acquiring the relationship between the position of the second feature portion in the real space and a position in the real space corresponding to the position of the first feature portion in the simulation space; a step for applying the position of the second feature portion in the real space and the relationship to the machine learning model, to thereby generate an operation plan for the mobile object; and a step for controlling the operation of the mobile object in accordance with the generated operation plan.

IPC Classes  ?

  • B25J 9/22 - Recording or playback systems
  • G05D 1/00 - Control of position, course, altitude, or attitude of land, water, air, or space vehicles, e.g. automatic pilot

79.

CONTROL METHOD FOR CONTROLLING TRANSPORT OF OBJECT, TRANSPORT DEVICE FOR TRANSPORTING OBJECT, AND WORK SYSTEM PROVIDED WITH TRANSPORT DEVICE

      
Application Number JP2023030106
Publication Number 2024/057836
Status In Force
Filing Date 2023-08-22
Publication Date 2024-03-21
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Takahara, Kazuma
  • Imai, Shinji

Abstract

This control method uses an image captured by an image capturing unit (234) to control transport of an object to a target position by using a first moving body (232). The control method comprises: a step for performing proximity control for causing the image capturing unit (234) to be in relative proximity to a characteristic part indicating a reference position different from the target position; a step for causing the image capturing unit (234), which has been put in relative proximity to the characteristic part by the proximity control, to acquire a first image obtained by photographing the characteristic part; and a step for causing the first moving body (232) to transport the object to the target position on the basis of the first image.

IPC Classes  ?

  • B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices

80.

JETANIZER

      
Serial Number 98453342
Status Pending
Filing Date 2024-03-17
Owner SHIMADZU CORPORATION (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Measuring apparatus and instruments, namely, a chemical reactor that converts carbon dioxide and carbon monoxide to methane for analyzing chromatograph elution; gas chromatography apparatus

81.

JETANIZER

      
Application Number 018999474
Status Pending
Filing Date 2024-03-15
Owner Shimadzu Corporation (Japan)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Measuring apparatus and instruments; chemical reactors that convert carbon dioxide and carbon monoxide to methane for analyzing chromatograph elution; gas chromatography apparatus.

82.

AUTOMATIC DISPENSING DEVICE

      
Application Number 18215023
Status Pending
Filing Date 2023-06-27
First Publication Date 2024-03-14
Owner Shimadzu Corporation (Japan)
Inventor Miyazaki, Koki

Abstract

An automatic dispensing device includes a gripper configured to grip a dispenser having a discharge nozzle with the discharge nozzle facing downward, a tip rack arrangement portion configured to arrange a tip rack in which pipette tips to be attached to the discharge nozzle are accommodated, a biasing member configured to bias the tip rack arrangement portion from below, and a moving unit configured to move the gripper relative to the tip rack arrangement portion.

IPC Classes  ?

83.

CHROMATOGRAPH

      
Application Number 18272707
Status Pending
Filing Date 2021-09-09
First Publication Date 2024-03-14
Owner Shimadzu Corporation (Japan)
Inventor Inohana, Yusuke

Abstract

A chromatograph including: a column 13 configured to separate a compound contained in a sample; a detection unit 2 configured to measure a predetermined physical quantity of the compound flowing out of the column; a measurement condition storage unit 411 in which one or a plurality of measurement conditions are stored; a measurement control unit 423 configured to set an operation of measuring each of a plurality of samples using any one of the measurement conditions stored in the measurement condition storage unit a plurality of times for each sample and execute all measurement operations set for the plurality of samples in random order; and a measurement data processing unit 424 configured to associate measurement data acquired by the detection unit with a sample to be measured for each measurement.

IPC Classes  ?

84.

X-RAY FLUORESCENCE ANALYSIS DEVICE

      
Application Number 18274617
Status Pending
Filing Date 2021-07-29
First Publication Date 2024-03-14
Owner SHIMADZU CORPORATION (Japan)
Inventor Saito, Yuta

Abstract

Provided is an X-ray fluorescence analyzer capable of performing an analysis under more favorable conditions depending on an analysis target. The X-ray fluorescence analyzer includes a detector 30, preamplifiers 41A, 41B configured to amplify a detection signal from the detector into a staircase wave signal at different signal amplification factors GA, GB, a differentiating circuit 42 configured to convert the staircase wave signal into a differential wave signal, an A/D converter 43 configured to convert the differential wave digital signal to a digital signal, a signal processing unit 160 configured to detect a peak value from the digital signal, discriminate and count the peak value, and generate a histogram, and an input unit 51 configured to set the energy range of the fluorescent X-rays to be analyzed. Any one of the preamplifiers is automatically selected based on maximum energy in the set energy range.

IPC Classes  ?

  • G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence

85.

METHOD FOR DRIVING LINEAR ION TRAP AND MASS SPECTROMETER

      
Application Number 18348753
Status Pending
Filing Date 2023-07-07
First Publication Date 2024-03-14
Owner SHIMADZU CORPORATION (Japan)
Inventor Nishiguchi, Masaru

Abstract

A method for driving a linear ion trap having rod electrodes arranged so as to surround a central axis includes: an ion-introducing step for introducing ions into an ion-capturing space surrounded by the rod electrodes, and for capturing the ions by a multipole RF electric field created within the ion-capturing space; and an ion-ejecting step for creating both a DC electric field for ion extraction extending from an external area outside the ion-capturing space into the ion-capturing space through a space between two predetermined rod electrodes neighboring each other around the central axis among the plurality of rod electrodes and the multipole RF electric field, and for sequentially ejecting ions according to their m/z from the ion-capturing space toward the external area through the space between the two predetermined rod electrodes by changing at least one of the multipole RF electric field and the DC electric field.

IPC Classes  ?

  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

86.

PRESSURE SENSOR

      
Application Number 18241674
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-03-14
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Takebayashi, Ryu
  • Imamura, Shinya

Abstract

A sheet-like diaphragm made from a non-metallic material, a main body block made from a non-metallic material, having a diaphragm facing surface facing a main plane of the diaphragm, disposed in a manner that the diaphragm facing surface is covered by the diaphragm, and provided with a fluid outlet and a fluid inlet facing the diaphragm side, a sensor head that has a recess for accommodating pressure transmission liquid, is disposed on a side opposite to the main body block across the diaphragm such that an opening of the recess is closed by the diaphragm, and is configured to detect pressure of fluid flowing between the diaphragm and the diaphragm facing surface by a deformation amount of the diaphragm are included. The fluid inlet and the fluid outlet are provided in a manner separated from the diaphragm further than the diaphragm facing surface.

IPC Classes  ?

  • G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed

87.

AUTOMATIC DISPENSING DEVICE

      
Application Number 18139133
Status Pending
Filing Date 2023-04-25
First Publication Date 2024-03-14
Owner Shimadzu Corporation (Japan)
Inventor Miyazaki, Koki

Abstract

An automatic dispensing device is provided with a sample container holder having a plurality of recesses, each of the recessed being configured to accommodate a sample container, a biasing member provided in each of the plurality of recesses, the biasing member being configured to bias the sample container accommodated in the recess upward, and a liquid dispensing mechanism having a discharge pipe for discharging a liquid from a tip end, the liquid dispensing mechanism being configured to discharge the liquid in a state in which the tip end of the discharge pipe is pressed against an inner part of the sample container at a predetermined dispensing target position from above.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

88.

ANALYZER AND DISPLAY METHOD

      
Application Number 18243966
Status Pending
Filing Date 2023-09-08
First Publication Date 2024-03-14
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Ogino, Kota
  • Harada, Akira

Abstract

An analyzer that analyzes one or more pieces of data acquired by electrophoresis separation of a sample includes a memory, a display unit, and a processor. The memory stores the one or more pieces of data. The display unit displays, based on the one or more pieces of data, a gel image, an electropherogram, a first size guide corresponding to the gel image, and a second size guide corresponding to the electropherogram. When the first size guide is located at a first position corresponding to a specific value associated with a size in the gel image, the processor displays a second size guide at a second position corresponding to the specific value in the electropherogram.

IPC Classes  ?

  • G06T 11/20 - Drawing from basic elements, e.g. lines or circles
  • G01N 27/447 - Systems using electrophoresis
  • G06F 3/04845 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range for image manipulation, e.g. dragging, rotation, expansion or change of colour

89.

QUADRUPOLE MASS SPECTROMETER

      
Application Number 18559161
Status Pending
Filing Date 2021-05-31
First Publication Date 2024-03-14
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Ueda, Manabu
  • Miyashiro, Hiroki
  • Taniguchi, Junichi

Abstract

A quadrupole mass spectrometer includes a quadrupole mass filter including: a main rod portion including four main rod electrodes; a pre-rod portion including four pre-rod electrodes, where, at an end opposite to the main rod portion, the four pre-rod electrodes are disposed to be aligned on an inscribed circle having the same radius centered on the ion optical axis, and, at the other end facing the main rod portion, two pre-rod electrodes facing each other across the ion optical axis and the other two pre-rod electrodes are disposed to be aligned on an inscribed circle having different radii centered on the ion optical axis; a main voltage applying unit to apply, to each main rod electrodes, a voltage created by superimposing a DC voltage and an RF voltage; and a pre-voltage applying unit to apply an RF voltage having a same frequency as the RF voltage to each pre-rod electrodes.

IPC Classes  ?

  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

90.

MICROCHANNEL DEVICE

      
Application Number 18237530
Status Pending
Filing Date 2023-08-24
First Publication Date 2024-03-07
Owner SHIMADZU CORPORATION (Japan)
Inventor Takeuchi, Ippei

Abstract

A microchannel device includes an opening that receives a test solution, a main channel that communicates with the opening, and a collection portion provided at an outlet-side end of the main channel. The collection portion includes a pool that stores the test solution, a connection channel that connects the pool with the outlet-side end, and a protrusion that is arranged in the connection channel to generate air bubbles between the protrusion and an inner wall of the connection channel to close the connection channel, upon receiving the test solution discharged from the main channel.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

91.

X-RAY FLUOROSCOPIC DEVICE

      
Application Number JP2023017041
Publication Number 2024/047943
Status In Force
Filing Date 2023-05-01
Publication Date 2024-03-07
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Matsuda Kazuyuki
  • Tsutsumida Yumi

Abstract

The present invention comprises a rotatable C-arm 17 that supports and causes an X-ray tube 13 and an X-ray detector 15 to face each other, an image generating unit 43 that uses a detected signal of the x-ray detector 15 to generate an X-ray image L, and an image display device 11 that displays the X-ray image L. The image display device 11 comprises: an image display unit 49 capable of displaying information display images D in parallel in a matrix shape; an input unit 51 for inputting an instruction for changing the position where image information K is displayed in the information display images D so that at least two X-ray images L are displayed adjacent to each other among the information display images D; and an image display control unit 57 that controls the image display unit 49 so that the X-ray images L are displaced adjacent to each other, on the basis of the content of the instruction.

IPC Classes  ?

  • A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment

92.

MASS SPECTROMETER

      
Application Number 18203356
Status Pending
Filing Date 2023-05-30
First Publication Date 2024-03-07
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Okamura, Shinichiro
  • Nishiguchi, Masaru

Abstract

An ion transport optical system includes N rod electrodes forming an N-pole arrangement externally tangent to a circle of diameter A1 at an ion-entrance end, where N is an even number not smaller than six. Four electrodes form a quadrupole arrangement externally tangent to a circle of diameter A2 at an ion-exit end, where A2

IPC Classes  ?

  • H01J 49/06 - Electron- or ion-optical arrangements
  • H01J 49/00 - Particle spectrometers or separator tubes
  • H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

93.

MICROORGANISM IDENTIFICATION METHOD

      
Application Number 18221829
Status Pending
Filing Date 2023-07-13
First Publication Date 2024-03-07
Owner
  • SHIMADZU Corporation (Japan)
  • Meijo University (Japan)
Inventor
  • Tamura, Hiroto
  • Yamamoto, Naomi
  • Kato, Teruyo
  • Shima, Keisuke
  • Funatsu, Shinji

Abstract

Provided is a non-transitory computer-readable medium storing a program for causing a computer to execute the steps including a step of subjecting a sample containing microorganisms to mass spectrometry to obtain a mass spectrum, a step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum, and an identification step of identifying which bacteria of serovar of Salmonella genus bacteria the microorganisms contained in the sample contain, based on the mass-to-charge ratio m/z, wherein at least one of two types of ribosomal proteins S8 and Peptidylpropyl isomerase is used as the marker protein.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
  • G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber

94.

ION CHROMATOGRAPHY ANALYSIS SYSTEM

      
Application Number 18241090
Status Pending
Filing Date 2023-08-31
First Publication Date 2024-03-07
Owner SHIMADZU CORPORATION (Japan)
Inventor Yonekura, Takuya

Abstract

An ion chromatography analysis system includes a system monitoring part being configured to detect an abnormality, to determine, based on a fluctuation rate in a certain time of the predetermined state of a most recent of the monitor value, whether the fluctuation is a short-term fluctuation that occurs in a short term or a long-term fluctuation that occurs in a long term, and to identify a cause of the abnormality by using whether the fluctuation is the short-term fluctuation or the long-term fluctuation.

IPC Classes  ?

  • G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
  • B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
  • B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
  • G01N 30/14 - Preparation by elimination of some components
  • G01N 30/16 - Injection
  • G01N 30/64 - Electrical detectors

95.

CELL CULTURE CONTAINER AND CELL CULTURE DEVICE

      
Application Number 18268670
Status Pending
Filing Date 2021-10-14
First Publication Date 2024-03-07
Owner Shimadzu Corporation (Japan)
Inventor
  • Inoue, Tsunehiro
  • Hashimoto, Toyoyuki
  • Yoneda, Yasuko
  • Takubo, Kenji
  • Fujiyama, Yoichi
  • Ohkubo, Tomoki
  • Ozeki, Eiichi
  • Takai, Ryogo
  • Goto, Hiroomi
  • Tomita, Sadamu

Abstract

A cell culture container includes: an insert member having a membrane on which a cell is seeded, the insert member defining a first inner space that functions as an anaerobic chamber; a container having an attachment/detachment portion to and from which the insert member is attachable and detachable, the container defining a second inner space that functions as an aerobic chamber; a sealing member that closes an opening of the aerobic chamber between the attachment/detachment portion and the insert member with the insert member being attached to the attachment/detachment portion; and a transfer mechanism that transfers force to the sealing member. The sealing member closes the opening in response to an input of the force from the transfer mechanism.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

96.

METHOD FOR ANALYZING METABOLITE OF MICROORGANISM

      
Application Number 18273856
Status Pending
Filing Date 2022-01-17
First Publication Date 2024-03-07
Owner
  • SHIMADZU CORPORATION (Japan)
  • NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
  • AJINOMOTO CO., INC. (Japan)
Inventor
  • Horie, Shinnosuke
  • Fujito, Yuka
  • Hasunuma, Tomohisa
  • Yoshida, Takanobu
  • Urahata, Erika

Abstract

Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.

IPC Classes  ?

  • G01N 30/72 - Mass spectrometers
  • C12N 1/20 - Bacteria; Culture media therefor
  • G01N 30/04 - Preparation or injection of sample to be analysed
  • G01N 30/26 - Conditioning of the fluid carrier; Flow patterns

97.

MAINTENANCE SYSTEM, MANAGEMENT DEVICE, AND MAINTENANCE METHOD

      
Application Number JP2023025654
Publication Number 2024/048087
Status In Force
Filing Date 2023-07-12
Publication Date 2024-03-07
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Kinoshita, Naoki
  • Isobe, Seiyu
  • Takezawa, Hidetaka

Abstract

Provided is a maintenance system wherein a management device manages a database, which stores solution information associated with the state of a medical device, and updates the database. The management device receives state information indicating the state of the medical device from the medical device, which is connected to a network of an organization, via a network outside of the organization. The management device determines solution information corresponding to the state of the medical device on the basis of the state information and the database and transmits the determined solution information to a terminal device having a display unit via the network outside of the organization.

IPC Classes  ?

  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades

98.

X-RAY PHASE IMAGING SYSTEM AND X-RAY PHASE IMAGING METHOD

      
Application Number JP2023028519
Publication Number 2024/048200
Status In Force
Filing Date 2023-08-04
Publication Date 2024-03-07
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Nagai, Ishikawa, Lisa
  • Doki, Takahiro
  • Morimoto, Naoki

Abstract

This X-ray phase imaging system (100) comprises: an imaging system (6) including an X-ray source (1), an X-ray detector (2), and a plurality of lattices; a first rotation mechanism (7) which relatively rotates a subject (90) and the imaging system; an image processing unit (81) which generates a three-dimensional dark field-of-view image (43); a filter processing unit (82) which performs a filter process for extracting linear portions (44) included in the subject at a plurality of angles; and a linear portion image generation unit (83) which generates a linear portion image (45) on the basis of the plurality of linear portions corresponding to a fiber (90b).

IPC Classes  ?

  • G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers

99.

PROBE ASSESSMENT METHOD AND SPM

      
Application Number 18268299
Status Pending
Filing Date 2021-06-09
First Publication Date 2024-02-29
Owner SHIMADZU CORPORATION (Japan)
Inventor
  • Arai, Hiroshi
  • Nakajima, Hideo
  • Yamasaki, Kenji
  • Iida, Eiji
  • Kogure, Akinori

Abstract

A method of assessing a probe by measuring a known sample whose shape is known with the probe in an electronic microscope, the known sample having a projection part on a surface thereof, and the projection part having a shape tapered toward a vertex thereof, the method comprising a step of measuring circle equivalent radius of the projection part, a step of comparing the circle equivalent radius with a first threshold value, and a step of determining that the probe is satisfactory when the width is less than the first threshold value, and a step of determining that the probe is unsatisfactory when the width is equal to or greater than the first threshold value.

IPC Classes  ?

  • G01Q 40/02 - Calibration standards or methods of fabrication thereof

100.

X-RAY IMAGING SYSTEM AND LEARNED MODEL PRODUCTION METHOD

      
Application Number 18363144
Status Pending
Filing Date 2023-08-01
First Publication Date 2024-02-29
Owner Shimadzu Corporation (Japan)
Inventor
  • Tsushima, Hiroaki
  • Sawada, Ryuji

Abstract

An X-ray imaging system is configured to acquire first and second images from a teacher X-ray image including an inspection target. Discrimination information to discriminate at least one of an area of the inspection target in the first and second images, and an area of a defect part is acquired. Machine learning for producing a learned model is performed by using input teacher data sets based on the first and second images, and output teacher data sets based on the discrimination information.

IPC Classes  ?

  • G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
  • G06T 7/00 - Image analysis
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