A defect detection device includes: an excitation unit configured to apply vibration to an inspection object; a vibration state image creation unit configured to measure by an optical means a vibration state in a measurement area on a surface of the inspection object to which the vibration is applied, and to create one or more types of vibration state images representing the vibration state in the measurement area depending on a result of the measurement; an optical image acquisition unit configured to acquire an optical image in the measurement area; an image display unit configured to display an image; and a display control unit configured to perform control to simultaneously display two images among the one or more types of vibration state images and the optical image for the same area in the measurement area on the image display unit.
A display method for displaying a plurality of pieces of data respectively obtained by electrophoretic separation for a plurality of samples. The first data includes a first peak corresponding to a separated component of the known sample. The second data includes a second peak corresponding to a separated component of the unknown sample. The display method includes: acquiring the plurality of pieces of data; detecting the first peak and the second peak respectively from the first data and the second data; setting a range included within a predetermined threshold from the first peak as a specified range; determining, for the second data, whether or not the second peak is included in the specified range; and displaying specifically the second peak, when the second peak is in the specified range.
Provided is a data processing device for processing data acquired by an electrophoretic analysis. A graph creator (31, 33) creates an electropherogram and/or a separation image of peaks on an electrophoretic channel. A display processor (37) displays a graph showing the electropherogram and/or the separation image on which a boundary line is drawn to define the inside and the outside of an analysis target range extending along an axis of a separation direction, with the inside and the outside being shown in different visual modes. An analysis condition setter (34) receives an operation by a user for moving the boundary line on the graph displayed and sets the analysis target range whose position and size on the axis are changed according to the received operation. A data-analysis processor (35, 36) carries out a predetermined computation using all or some of peaks included in the analysis target range.
This treatment support system (100) is provided with an irradiation unit (10) for irradiating a medical agent (102) administered to a subject of a cancer subject (101) with therapeutic light in treatment for killing a cancer cell by irradiating the medical agent with the therapeutic light, a light detection unit (30) for detecting fluorescence excited by the therapeutic light, a control unit (51), and a display unit (60). The control unit (51) includes a signal acquisition unit (51a) for acquiring a fluorescence signal, an analysis processing unit (51c) for generating the analysis image (203) that displays a treatment progress distribution for each region of the treatment site based on a change along time series of the fluorescence signal, and an image output unit (51d) for outputting the analysis image (203).
An acquirer that acquires, based on measurement data acquired over time using an analysis device, measurement waveform data, the measurement data representing a change in domain direction of the measurement data, and an estimator that acquires estimation waveform data that is what noise data is at least partially removed from the measurement waveform data, are included. The estimator acquires the estimation waveform data as data such that the noise data included in the measurement waveform data has a correlation in the domain direction. Thus, a peak shape can be correctly estimated based on measurement waveform data to which noise is added.
A wearable device wearable by a subject includes: a base; a first arm extending from the base; a second arm extending from the base; a first cable disposed along the first arm; a first sensor that is connected to a first end of the first cable, attached to a body of a subject who is wearing the wearable device, and detects physical body data of the subject; and a signal processor that is connected to a second end of the first cable and processes a detection signal from the first sensor. The signal processor is attached to the base.
A diagnostic apparatus for nuclear medicine executes an attenuation correction processing with a high degree of precision relative to the radiation image and an estimation method of an attenuation coefficient image without irradiating radiation to an examination subject using an external radiation source. The diagnostic apparatus has a memory storage, a reconstruction element, a position deviation calculating element, a position correction element generating the corrected attenuation coefficient image, and a attenuation correction element using a corrected attenuation coefficient image HF and a concurrent counting data DK.
In a defect detection device (10), an exciter (11) gives a test object (S) a vibration with a variable frequency. A vibration state measurer (15, 163) performs a measurement of the vibration state of the surface of the test object by an optical means while the vibration is given to the test object, and determines, for each position on the surface, a numerical value representing the vibration state based on a result of the measurement. A judgment-index-value determiner (164) determines a judgment index value by Fourier transform based on the numerical value representing the vibration state at each position, where the judgment index value is a numerical value representing a strength of the vibration for each wavenumber. A wavenumber-wavelength determiner (165) determines, based on the judgment index value determined for each wavenumber, a wavenumber or wavelength of an elastic wave induced in the test object by the vibration.
The present invention relates to the technical field of analytical instruments, in particular to an ion source and a mass spectrometer. The ion source includes dielectric barrier discharge assemblies, wherein the dielectric barrier discharge assembly is composed of a first electrode plate, a dielectric spacer plate and a second electrode plate which are in close proximity in parallel in sequence, and a first through hole penetrating through the first electrode plate, a second through hole penetrating through the dielectric spacer plate and a third through hole penetrating through the second electrode plate are disposed corresponding to each other to form a gas passageway for gas to be ionized. The ion source of the present invention is simple in structure, compact, small in size, and extremely low in energy consumption, and is particularly suitable for use on miniaturized hand-held instruments.
A gas chromatograph is provided with a communication unit, a setting processing unit, a first operation reception unit, and a maintenance processing unit. The communication unit communicates with an outside. The setting processing unit sets any one of the plurality of maintenance modes to a default maintenance mode in response to an input from the outside via the communication unit. The first operation reception unit is provided in the housing and is configured to accept a progress operation for progressing a maintenance sequence corresponding to the default maintenance mode. The maintenance processing unit progresses the maintenance sequence stepwise each time the progress operation is accepted by the first operation reception unit. The first operation reception unit is commonly used even in a case where any one of the plurality of maintenance modes is set to the default maintenance mode.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
A training method includes: acquiring a pseudo noise waveform indicating an assumed noise; acquiring a pseudo peak waveform not including the pseudo noise; generating a pseudo signal waveform by adding the pseudo noise waveform and the pseudo peak waveform; and updating an estimation model based on the pseudo signal waveform, in which the acquiring the pseudo noise waveform includes: causing an analysis device to execute noise measurement generating the pseudo noise waveform a plurality of times; calculating a similarity degree of a plurality of pseudo noise waveforms generated by the noise measurement performed the plurality of times; and executing prescribed processing according to the similarity degree.
Provided is an X-ray fluorescence analyzer capable of reducing consumption of a gas constituting a measurement atmosphere. The X-ray fluorescence analyzer is provided with a sample chamber configured to place a sample therein, a measurement chamber arranged adjacent to the sample in the sample chamber, an X-ray tube configured to irradiate the sample with X-rays, and a detector configured to detect the X-rays reflected by the sample. The detector is provided with a passage through which the X-rays reflected by the sample pass, the passage being positioned in the measurement chamber-, and a hole connecting the passage and an outside of the detector.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
13.
MANAGEMENT SYSTEM FOR MANAGING OPERATION OF PREPARATIVE LIQUID CHROMATOGRAPH APPARATUS
A management system (1) for managing an operation of a preparative LC (100), the management system (1) including an injection registration part (2) configured to display an injection registration screen in response to a request from the user and register a container designated by the user on the injection registration screen as an injection target container, a result display part (6) configured to display a chromatogram created based on an output signal of a detector (108) of the preparative LC, create fractionation information indicating a correspondence relationship between a position on the chromatogram of each fraction collected in an individual container by a fractionator (112) of the preparative LC and a position of a container in which each fraction is collected, and display the created fractionation information as a fractionation result screen, a reinjection registration part (8) configured to allow the user to designate a fraction to be reinjected on the fractionation result screen, and configured to register a container in which the fraction designated by the user is collected as a reinjection target container when the fraction to be reinjected is designated by the user, and a controller (4) that controls operation of an injector of the preparative LC so that liquid contained in the container registered as the injection target container or the reinjection target container is injected.
G01N 30/14 - Preparation by elimination of some components
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
A method for analyzing coffee components includes, in this order, preparation step of preparing a sample solution containing coffee components extracted from coffee beans; dilution step of diluting the sample solution; and detection step of detecting the coffee components by performing liquid chromatography on the diluted sample solution. The detection step includes passing the sample solution through a column packed with a packing material having pentafluorophenylpropyl group, and then detecting trigonelline and pyrocatechol in the passed sample solution by a photodiode array ultraviolet-visible absorbance detector.
In a sample analyzing device (1), a storage section (21) holds information concerning measurement conditions and data-analysis methods for a plurality of known compounds as well as information concerning a plurality of filters each of which extracts a subset of the known compounds. A measurement controller (224) obtains measurement data of a sample by performing a measurement based on the measurement conditions held in the storage section. A filter selection receiver (221) receives an input for selecting one of the filters as a data-analysis filter. A data-analysis-target-compound extractor (223) extracts, as data-analysis target compounds, a subset of the known compounds by the data-analysis filter. A display controller (226) displays, on a display section (26), a first data-analysis screen for displaying measurement data of the data-analysis target compounds and a second data-analysis screen for displaying all measurement data.
A cell culture system includes: a cell culture container disposed in an anaerobic chamber; and an external apparatus. The external apparatus has a main body unit disposed in the anaerobic chamber and an operation unit disposed outside the anaerobic chamber. The main body unit is configured to perform a predetermined process onto the cell culture container. The operation unit is configured to transmit or receive a signal associated with the predetermined process to or from the main body unit by wireless communication.
An inspection apparatus comprises a first channel that passes an aqueous sample therethrough, a second channel that passes a phosphate eluent therethrough, a separation device that separates by size a group of substances contained in the aqueous sample, and a TOC device that oxidizes each substance separated by the separation device by size and measures organic carbon contained in each substance. The separation device includes a column for size-exclusion chromatography and a sample injection unit that introduces the aqueous sample into a mobile phase passed through the first channel. The second channel is connected to the first channel between the column and the sample injection unit, and causes the phosphate eluent to merge with the aqueous sample between the sample injection unit and the column.
An injector includes an injection device and a round turret provided on a front side of the injection device. A sampler is provided with a vial holder and a conveyance arm. The injector has an accessible structure in which a moving path of the conveyance arm of one sampler arranged on the side of the two injectors for accessing the round turret of each of the two injectors is secured regardless of the size of the round turret, when two injectors are arranged so that the back sides of the injection devices face to each other.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
The object of the disclosure is to prevent erroneous transition of an operation mode to an operation limitation mode. A control device 6 includes a controller 62. The controller 62 counts the number of times of occurrence of each of multiple types of abnormalities occurred in a vacuum pump 1, and issues a critical alarm in a case where the number of times of occurrence of each of the multiple types of abnormalities exceeds a predetermined threshold.
An X-ray imaging apparatus is provided with an X-ray source, a detector, a C-shaped arm, a hose for accommodating wiring, the hose including a base side portion and an opposite side portion, a base including a C-shaped arm support portion and a hose attachment portion to which the base side portion is rotatably attached, a biasing member for biasing the base side portion of the hose to rotate about the hose attachment portion in the first rotation direction outwardly away from the C-shaped arm, and an image processing unit.
An analysis device produces learning data for training an estimation model. More specifically, the analysis device obtains a plurality of reference waveforms. In addition, the analysis device specifies information about a peak for each of the plurality of reference waveforms according to a certain criterion. The analysis device assigns the specified information about the peak to each of the plurality of reference waveforms.
To enable a correct and easy discrimination of microorganisms, a microorganism discrimination method includes: acquiring mass spectra related to known microorganisms which belong to the same species and whose subspecies, strains or types are known (S11); retrieving a list describing m/z values of marker-candidate proteins which are supposed to vary in mass among different subspecies, strains or types (S12); creating a mask which gives non-zero values only within a predetermined range including each of the listed m/z values (S14); masking each of the mass spectra (S15); creating wavelet images by performing continuous wavelet transform on the mass spectra (S16); creating a discriminant model by machine learning using, as training data, the wavelet images and information of the subspecies, strains or types of the known microorganisms; and discriminating the subspecies, strain or type of an unknown microorganism by applying a mass spectrum of this microorganism to the discriminant model.
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
H01J 49/00 - Particle spectrometers or separator tubes
23.
DATA GENERATION METHOD AND DEVICE, AND DISCRIMINATOR GENERATION METHOD AND DEVICE
A data generation device according to the present invention is a data generation device configured to simulatively generate data used when creating, by machine learning, a discriminator configured to detect a peak observed in a signal waveform, the data generation device including: a parameter frequency information acquisition unit configured to acquire information on frequency of a predetermined shape parameter which characterizes a shape of a signal waveform from a plurality of signal waveforms collected only in a target field of machine learning for creating the discriminator; and a simulated waveform generation unit configured to generate a simulated signal waveform which is able to include overlapping of a plurality of peaks and noise using the information on frequency of the shape parameter, in which the simulated signal waveform is provided as data for training or evaluating machine learning.
This attenuation coefficient image generation method includes a step of generating an input image (6), a step of generating an intermediate image (7) including an image relating to tissue areas based on the input image (6), and a step of generating an attenuation coefficient image (9) based the intermediate image (7) and known attenuation coefficients of tissue areas.
An imaging position correction application introduction support system is provided with a storage unit and a display unit. The imaging position correction application introduction support system is configured to cause the storage unit to store at least one of the number of times the imaging position correction application was used and a degree of correction when the relative position of the X-ray irradiation unit with respect to the specific site of the subject was corrected by the imaging position correction application, as the tentative use information on when the imaging position correction application is tentatively used. The display unit displays the information based on the tentative use information.
An automatic sample injection device is configured to perform an injection operation of a sample to an analyzer by a sampling mechanism (2) for sucking and dispensing a solvent. The automatic sample injection device is provided with solvent arrangement locations (14) at which a plurality of solvents each accommodated in a vial is arranged, a method setting unit (16) configured to set a method of a predetermined operation using a solvent based on information input by a user, a solvent arrangement setting unit (20) configured to set the number or types of solvents to be arranged at the solvent arrangement locations; and a control unit (6) configured to control the sampling mechanism to execute the predetermined operation with a method set by the method setting unit.
An X-ray imaging apparatus has a position determination support unit for that allows adjustment of the relative angular relationship between a detection surface of the X-ray detection element and the irradiation direction of the X-ray of the X-ray irradiation element. The X-ray imaging apparatus has an X-ray irradiation element, an X-ray detection element, an angular relationship detection element that detects the relative angular relationship between the detection surface of the X-ray detection element and the irradiation direction of X-rays of the X-ray irradiation element. A projection element projects the irradiation position marker indicating the position where the X-ray is irradiated from the X-ray irradiation element on a body surface of a subject. The projection element changes the display mode of the irradiation position marker based on the deviation level relative to the preset setting angle of the detected angular relationship.
An analysis device produces learning data for training processing of an estimation model More specifically, the analysis device obtains a plurality of reference waveforms for a given type of device. In addition, the analysis device specifies information about a peak for each of the plurality of reference waveforms according to a criterion corresponding to the given type of device. The analysis device assigns the specified information about the peak to each of the plurality of reference waveforms.
An X-ray imaging apparatus includes an X-ray irradiation unit, an X-ray detection unit, and a correction information acquisition unit configured to identify an outer edge of each of a plurality of predetermined portions of one imaging target of the subject in an X-ray image and acquire position correction information for correcting a relative position of the X-ray irradiation unit with respect to the imaging target of the subject based on a positional relation between the identified outer edges of the plurality of the predetermined portions. The position correction information includes a relative moving direction and a movement amount for correcting the relative position of the X-ray irradiation unit with respect to the imaging target of the subject to a position where the X-ray image in which the positional relation between the outer edges of the plurality of predetermined portions is imaged can be captured.
National Cerebral and Cardiovascular Center (Japan)
Inventor
Kawakami, Daisuke
Ihara, Masafumi
Saito, Satoshi
Abstract
The present disclosure provides a method of preventing or delaying the progression from mild cognitive impairment (MCI) to dementia or a therapeutic agent therefor.
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A resin tube connection device includes a resin tube, a resin expanding portion and a metal sleeve. The resin expanding portion has a sealing surface being able to come into contact with a contact surface. Further, the resin expanding portion has a second flow path that communicates with a first flow path of the resin tube and opens in the sealing surface. The sealing surface projects farther than an end surface of the metal sleeve in an axial direction. The maximum length of a contact region where the resin expanding portion and the metal sleeve come into contact with each other in the axial direction in an outer surface is larger than the thickness of a resin layer in a radial direction.
F16L 21/04 - Joints with sleeve or socket with elastic sealing rings between pipe and sleeve or between pipe and socket, e.g. with rolling or other prefabricated profiled rings in which sealing rings are compressed by axially-movable members
An object is to increase an efficiency of removing carbon dioxide derived from inorganic carbon. An inspection apparatus includes: a column that separates a group of substances contained in an aqueous sample by size; an addition unit that adds a reagent, which acidifies the aqueous sample, into a channel; a degassing unit provided downstream of the addition unit for degassing carbon dioxide; a measurement unit that measures organic carbon contained in each substance from which the carbon dioxide has been removed; and a temperature maintaining unit that maintains a temperature of each of the column and a container in which a gas-permeable tube of the degassing unit is housed.
A wire rope inspection device (100) is provided with a first detection coil (30) and a second detection coil (40), and a processing unit (61). The second detection coil is arranged to be inclined to the first detection coil when viewed from a direction (X-direction) perpendicular to a first direction (Z-direction) along which the first detection coil moves relative to the wire rope (W). The processing unit identifies an abnormality position of the wire rope in the first direction based on a detection signal detected by the first detection coil and identifies an area of the abnormality position of the wire rope in a cross-section based on a detection signal detected by the second detection coil.
G01N 27/83 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables for investigating the presence of flaws by investigating stray magnetic fields
34.
Preparative Liquid Chromatograph Apparatus and Method for Assisting Determination of Preparative Separation Conditions
In a preparative liquid chromatograph apparatus where a sample containing compounds temporally separated from each other by LC is introduced into a detector and a fraction collector to collect fractions of the sample each containing one or more compounds. A result storage section stores analysis results obtained for a plurality of samples by performing, for each identical sample, LC analyses under different separation conditions. A display-target selection receiver displays an analysis result display screen having a plurality of result display areas for individually displaying results of different LC analyses and a selection indication area for allowing a user operation for selecting one sample from a plurality of samples, and receives the user operation in the selection indication area. An analysis result display processor retrieves, from the result storage section, a plurality of analysis results corresponding to the selected sample, and displays the analysis results in the result display areas.
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
SHIMADZU CORPORATION (Japan)
Inventor
Fujito, Yuka
Hattori, Takanari
Hasunuma, Tomohisa
Abstract
An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
A heater for ionization is used to produce ions from a sample. The heater for ionization has a bobbin, an electric heating wire and an electrode. The bobbin extends in one direction. The electric heating wire is wound around the bobbin. The electrode is welded to the electric heating wire. In the bobbin, a groove portion extending in the one direction is formed. The electrode is fitted into the groove portion.
An odor evaluation device according to the present invention includes a gas recovery unit, and a cleaning gas supply unit. The gas recovery unit includes an inlet port configured to introduce a sample gas containing odor components, an outlet port configured to detachably mount a sample bag for recovering the sample gas, a flow path connecting the inlet port and the outlet port, and a switching valve arranged in the flow path to open and close the outlet port. The cleaning gas supply unit is configured to supply a cleaning gas from an upstream side of the switching valve toward the outlet port in a state in which the sample bag is not mounted on the outlet port and the switching valve is opened.
In a multi-analyte multi-component analysis, multiple kinds of numerical information are obtained for each sample as measurement and data-analysis results for multiple compounds. A threshold-based flag condition is set for each of two or more kinds of numerical information according to user operations. Multiple categories, each having a determination condition including the combination of the presence/absence of the flags corresponding to the two or more kinds of numerical information, are set according to user operations. For each sample-compound combination, each kind of numerical information is tested as to whether it satisfies the flag condition, and is flagged if it satisfies the condition. Each sample-compound combination is tested as to the presence/absence of the flags according to the determination condition of each category, to identify combinations belonging to any category. The identified combinations are displayed, with each combination related to the corresponding category or each category visually distinguished from the other.
In a mass spectrometer employing laser ionization to ionize a sample, a known sample is irradiated with laser light multiple times, and multiple sets of profile data are acquired each of which is a spectrum showing the relationship between the m/z values and intensities of ions generated from the known sample by one laser irradiation (Step S11). Those sets of profile data are sorted into groups so that one or more sets of profile data are included in each group (Step S12). For each group, a peak list is created which describes the m/z value and intensity of each peak originating from the known sample based on the one or more sets of profile data included in the group (Step S13). A discriminant model for discriminating an unknown sample is created using the peak lists of the plurality of groups and information concerning the kind of the known sample as training data.
A testing method for a joined body, in which a second pipe member having an outer diameter smaller than that of a first pipe member having at least one through hole is inserted into the first pipe member and the second pipe member is expanded to form a joining portion, the testing method includes: applying an elastic wave vibration to the joined body of the first pipe member and the second pipe member, for plural visual field regions at different positions in a circumferential direction of the joined body, acquiring a vibration distribution of the second pipe member measured through the through hole and a vibration distribution of the first pipe member in a visual field region including the joining portion of the first pipe member and the second pipe member, which are measured optically and in a batch, and determining quality of joining in the entire joining portion based on the acquired vibration distributions.
In a chromatographic analyzer which performs a measurement on multiple compounds for each of the multiple samples, a data-analysis processor calculates, for each sample, multiple pieces of numerical information obtained by data analysis on multiple compounds, based on measurement data. A table creator creates a two-dimensional table by arranging sample identifier in one direction of the table and compound identifier in the other direction, and assigning numerical information obtained for a combination of one sample and one compound to a cell of the table corresponding to the combination. A cell selection receiver displays the table on a display screen and receives a selection of a cell or cells according to a user operation on the displayed table. A selected information outputter outputs or displays the numerical information in the selected cell(s) in a predetermined format along with the sample and compound identifiers corresponding to the cell(s).
A training support method includes: acquiring a first chromatogram; displaying a first chromatogram image; acquiring a second chromatogram identical or similar to the first chromatogram and second peak information specifying one or more peaks of the second chromatogram from a chromatogram DB; displaying a second chromatogram image and a second peak information image; receiving input, by a user, of first peak information specifying one or more peaks of the first chromatogram; and training an estimation model based on the first chromatogram and the first peak information.
A sensory test and entrusted analysis method includes: receiving, by a second device, information identifying a sample, the information being transmitted from a first device; registering, by the second device, the information identifying the sample and a sensory evaluation item about the sample; adding, by the second device, identification information to the information identifying the sample; transmitting, by the second device, the identification information and an analysis item corresponding to the sensory evaluation item to a third device; receiving, by the second device, the identification information and an analysis result corresponding to the analysis item of the sample from the third device; registering, by the second device, a sensory result generated about the sample; and transmitting, by the second device, the analysis result and the sensory result to the first device.
A holder for drying includes a first member including a first tubular portion that protrudes like a tube and an annular second member that can fix filter paper in a flat state under tension by being fitted over the filter paper to surround an outer side of the first tubular portion while the filter paper is carried on the first tubular portion.
G01N 21/3559 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for determining moisture content in sheets, e.g. in paper
A mass spectrometer (ion analyzer) includes: an ionization chamber; a sample probe fixed to a wall of the ionization chamber and configured to nebulize a liquid sample into the ionization chamber; a gas heater including a tubular member having both end walls and a peripheral wall, a heater configured to heat the inside of the tubular member, a gas flow inlet and a gas flow outlet provided in the peripheral wall or the end wall of the tubular member, and a gas flow outlet pipe having one end connected to the gas flow outlet and the other end inserted into the ionization chamber; a fixture configured to fix the gas heater to the wall of the ionization chamber; and a cooling unit configured to cool the fixture.
H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
46.
SAMPLE PURIFICATION APPARATUS, ANALYSIS SYSTEM, AND SAMPLE PURIFICATION METHOD
A sample purification apparatus includes a container for separating a mixed sample based on a specific gravity difference with the use of a heavy solution, a heavy solution introduction portion for introduction of the heavy solution into the container, a flow-out portion provided vertically above the heavy solution introduction portion in the container, the flow-out portion arranged so that a supernatant of a solution in the container due to the introduction of the heavy solution is flowed out to the outside of the container, and a collector provided vertically below the discharge portion in the container, the collector collecting a component in the mixed sample, the component being lighter in specific gravity than the heavy solution from the supernatant flowed out from the flow-out portion.
National University Corporation Tokai National Higher Education and Research System (Japan)
Inventor
Ikehara, Tatsuya
Mano, Kazune
Tomita, Hideki
Terabayashi, Ryohei
Yoshida, Kenji
Ninomiya, Shin-Ichi
Abstract
A column 2 is provided in a gas capturing unit 20 for capturing sample gas. A gas supply unit 1 supplies carrier gas for sending sample gas into the column 2. A gas separation mechanism 100 guides carrier gas in the column 2 to the outside of the column 2 by setting the lead-out path 5 to negative pressure with respect to the inside of the column 2. A heating unit 23 heats the column 2 to desorb sample gas captured by the gas capturing unit 20. Sample gas desorbed from the gas capturing unit 20 is introduced into a cell 31. A light source unit 32 irradiates sample gas in the cell 31 with light. An analysis unit 3 analyzes sample gas based on an intensity change of light emitted by the light source unit 32.
A liquid chromatograph (1) includes a liquid-sending unit (20) for sending a mobile phase from a reservoir (11) to a column (14) through a tube (12) at a predetermined pressure. The unit (20) includes a pump (21) having a suction port (211) connected to the reservoir and an ejection port (212) connected to the tube directly or via another pump. A check valve (232) is provided for the ejection port. For the precompression process for opening this valve, a pressure application controller (27) controls the pressure applied to the mobile phase within the pump, based on the compressibility of the mobile phase and the amount of compression of the inner wall of the pump resulting from the pressure application, so as to reach the pressure at which the check valve opens before the mobile phase suctioned from the suction port is to be ejected from the ejection port.
A fraction collector (14) that is provided downstream of a detector (10) and for separating an eluate eluted from a separation column (8) into a plurality of parts and collecting each of the parts into a plurality of containers respectively, and a controller (16) configured to execute fractionation operation for each sample injected at one time into the mobile phase are provided. In the fractionation operation, the controller detects components separated from each other in the separation column (8) as peaks individually based on a signal output from the detector (10), and controls operation of the fraction collector (14) such that the components detected as the peaks are collected in different containers. The controller (16) is configured to set a reference number of the number of components in a sample injected into the mobile phase, to count the number of components detected as the peaks for each sample injected into the mobile phase at a time by the injector (6), and to determine that the fractionation operation of the sample is completed when the number of components counted reaches the reference number and all components as many as the reference number are collected in the container.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
50.
CAP ATTACHMENT-DETACHMENT DEVICE AND PRE-PROCESSING DEVICE
A cap attachment-detachment device includes an operation portion that moves in an up-and-down direction, and grips and rotates a cap so as to attach the cap to or attach the cap from a container. The operation portion includes a first grip claw, a second grip claw and the pressing member. The first grip claw and the second grip claw are provided to be opposite to each other and configured to be capable of applying an obliquely upward force inwardly to an upper portion of a side surface of the cap. The pressing member is configured to be capable of coming into contact with an upper surface of the cap.
This defect inspection apparatus (100) is provided with an excitation unit (1), a laser illumination unit (2), an interference unit (30), an imaging unit (31), a holding member (4) for holding the imaging unit at a position spaced apart from an inspection target (90) by a predetermined distance, a connecting member (5) for connecting the holding member or the imaging unit and the excitation unit, and a controller (6) for generating an image (61) related to the propagation of an elastic wave on an inspection target.
A data measurement system (10) includes a plurality of measurement apparatuses (130), a signal transmitter (110), and a data processing apparatus (150). The signal transmitter (110) transmits a trigger signal to the plurality of measurement apparatuses (130). The data processing apparatus (150) obtains from each of the plurality of measurement apparatuses (130), measurement data measured during a period between a start signal corresponding to the trigger signal transmitted at first time and an end signal corresponding to the trigger signal transmitted at second time later than the first time. The data processing apparatus (150) temporally aligns start signals in the obtained data with each other and aligns end signals in the obtained data with each other, and presents the measurement data from the plurality of measurement apparatuses (130) to a user.
An infrared Raman microscope capable of switching to and performing infrared spectroscopic analysis or Raman spectroscopic analysis for a sample on a stage includes an infrared light detection system, a Raman light detection system, a display unit, a display switching processing unit, and storage processing units. The infrared light detection system and the Raman light detection system photographs a visible image at different magnifications. The display unit displays the visible image of the sample in a display area in association with coordinates on the stage. The display switching processing unit switches and displays the visible image in the same image display area. In a case where a measurement position of the infrared spectroscopic analysis or the Raman spectroscopic analysis is designated on the display area, the storage processing units store a point of coordinates on the stage corresponding to the measurement position.
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
54.
Method, System, and Device for Designing Experimental Protocol
A method for designing an experimental protocol capable of coping with more advanced processing is provided. A system according to an aspect includes at least one experimental device, a controller, and a terminal device. The controller controls the at least one experimental device to execute an experimental protocol defining processing order of the at least one experimental device. The terminal device designs the experimental protocol in a form of an oriented graph in accordance with a GUI operation performed on a specific application by a user. A plurality of nodes are selectable in the terminal device as a vertex of the oriented graph and the plurality of nodes include a processing node corresponding to processing by each of the at least one experimental device and a conditional branch node corresponding to conditional branch processing.
A mass spectrometer includes: a storage unit 411 which stores, for an ion having a predetermined mass-to-charge ratio, a reference value which is a value lower than a maximum value of a measured intensity of the ion, the maximum value being obtained by optimizing a measurement parameter of each unit; and a parameter adjustment unit 43 configured to adjust a measurement parameter of each unit such that a measured intensity of the ion having the predetermined mass-to-charge ratio equals the reference value when a sample containing the ion is measured.
An X-ray fluorescence analyzer is provided with an X-ray source for irradiating a sample with X-rays, a detector for detecting fluorescence X-rays emitted from the sample due to X-ray irradiation, and a steel sample chamber for accommodating the sample. At least a part of an inner surface of the sample chamber is coated with a layer made of aluminum derived from molten aluminum, or substantially an entire surface of the inner surface of the sample chamber is coated with the layer made of aluminum derived from molten aluminum.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
57.
INFRARED RAMAN MICROSCOPE AND DATA PROCESSING METHOD
An infrared spectrum display processing unit performs processing of displaying an infrared spectrum obtained by infrared spectroscopic analysis in a graph representing a relationship between a wave number and intensity. A data conversion processing unit performs processing of converting a Raman spectrum obtained by Raman spectroscopic analysis into an equal interval Raman spectrum in which data points are plotted by wave numbers at equal intervals. A Raman spectrum display processing unit performs processing of displaying an equal interval Raman spectrum as a graph representing a relationship between a wave number and intensity.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
An analysis result of an infrared spectrum at each measurement position is mapped and displayed in an infrared map display area as infrared data in association with a point of coordinates of each measurement position. An analysis result of a Raman spectrum at each measurement position is mapped and displayed in a Raman map display area as Raman data in association with a point of coordinates of each measurement position. In a case where an optional measurement position is designated in the infrared map display area and the Raman map display area, an infrared spectrum and a Raman spectrum associated with the designated measurement position are graphically displayed in the same graph display area.
A method of processing an initial spectrum of a sample acquired by processing an output of an X-ray detector is provided. A processor calculates a predictive value of a count value forming sum peaks, for each of one or more elements constituting the sample, using a count value and a value of energy of characteristic X-rays in the initial spectrum energy and subtract the predictive value calculated for each of the one or more elements constituting the sample from the count value of the initial spectrum to remove the sum peaks from the initial spectrum.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
A second device performs receiving an analysis result of analyzing a food sample by an analysis instrument, examining the analysis result to obtain an examination result, acquiring first information regarding whether the analysis result is made public or private and second information regarding whether the examination result is made public or private, storing the first information and the analysis result with the first information and the analysis result associated with each other and storing the second information and the examination result with the second information and the examination result associated with each other, and performing machine learning for predicting an examination result using, as training data, at least either the analysis result or the examination result, the analysis result or the examination result being set public.
A certainty factor of peak picking can be calculated when the peak picking is performed using semantic segmentation technology. An analysis device divides a target waveform into a plurality of partial waveforms, determines a peak waveform that becomes a peak portion among the plurality of divided partial waveforms using a trained model, and calculates the certainty factor of a determination result of the peak waveform using data output from the trained model when the peak portion of the target waveform is determined using the trained model.
In a mass spectrometer provided with a measurement section (1) including a collision cell (17) and a mass separator (20-23) for a mass spectrometric analysis of product ions, a CES-method-condition determiner (321) determines collision-energy (CE) values for a collision energy spread (CES) method according to given conditions including the range and number of CE values, in such a manner that n+1 CE values to be used when the number is n+1 (where n is an integer equal to or greater than three) include n collision-energy values used when the number is n and one additional CE value different from the n CE values. An analysis controller (30) sequentially changes the collision energy to the n+1 CE values and controls the measurement section to execute an MS/MS analysis under each CE value. A data processor (33) obtains a cumulative mass spectrum by accumulating mass spectra respectively obtained under different CE values.
[Problem to be solved] To provide a method for identifying a marker for discriminating a microorganism based on a small amount of actual measurement data.
[Problem to be solved] To provide a method for identifying a marker for discriminating a microorganism based on a small amount of actual measurement data.
[Solution] A method for identifying a marker for discriminating a microorganism, including steps of:
Step 1: Selecting a microorganism whose entire genome has been decoded,
Step 2: Obtaining molecular weight-related ion peaks of a protein of the microorganism,
Step 3: Obtaining an actual m/z value of each peak from the molecular weight-related ion peaks,
Step 4: Calculating a theoretical m/z value of the protein present in the microorganism,
Step 5: Comparing the theoretical m/z value with the actual m/z value, and assign the actual m/z value to a protein and an amino acid sequence thereof that have theoretical m/z values that match the actual m/z values,
Step 6: Obtaining an amino acid sequence similar to the protein assigned in Step 5 above,
Step 7: Calculating the theoretical m/z value of the protein of the microorganism selected according to discrimination and classification, and
Step 8: Comparing the theoretical m/z values of the above protein and identify the theoretical m/z value with difference as a marker for discrimination.
An apparatus for emitting an incident laser beam that is a linearly polarized laser beam at a predetermined intensity, includes: an intensity changing optical element (polarization beam splitter) disposed on the optical path of the incident laser beam, for changing the intensity of an outgoing laser beam by allowing a transmission of a component of the incident laser beam polarized in a predetermined variable transmission direction and to rotate around the optical axis of the incident laser beam within a range of at least 90° with respect to a predetermined reference angle; and a polarization direction changing optical element (concave lens) disposed upstream the optical path of the incident laser beam with respect to the intensity changing optical element, and for changing the polarization direction of the incident laser beam and to emit the incident laser beam, the change direction being variable.
A mass spectrometer includes an ion source including: an ionization chamber including an ion ejection hole, and an electron introduction port and an electron discharge port; a repeller electrode; a filament; a trap electrode; and a magnetic field forming unit. A first distance in a direction along the ion optical axis between an end of the electron introduction port on an ion ejection hole side and an inner face of a wall of the ionization chamber in which the ion ejection hole is formed and/or a second distance in a direction along the ion optical axis between an end of the electron introduction port on a repeller electrode side and the repeller electrode, is set to be larger than a radius of gyration of the thermal electron estimated based on energy imparted to the thermal electron and intensity of the magnetic field formed by the magnetic field forming unit.
A freezing apparatus includes a tube that stores a freezing target, an electric pipetter that is actuated for injection and discharge of a liquid into and from a tube and for movement of the tube, and a liquid nitrogen tank that stores refrigerant for freezing the freezing target. The tube has, at a bottom thereof, an opening smaller in size than the freezing target. The electric pipetter discharges the liquid from the tube through the opening after the injection of the liquid into the tube, and moves the tube to the liquid nitrogen tank.
Provided is a unit-type analyzer (1) including: a system controller (80); a plurality of analyzing units (60), with each analyzing unit including a main power switch (70) configured to turn on and off electric power to the analyzing unit, and a software switch (66) provided separately from the main power switch configured to turn on and off a communication with the system controller; and a software-switch operation-mode setter (65) configured to perform a setting for enabling or disabling an operation on the software switch included in each analyzing unit.
Degradation in performance of document search is automatically detected. When document data is added to a database, a learning unit updates a language model-by machine learning. A performance evaluation unit respectively calculates a first statistical value and a second statistical value related to ranking of each of a plurality of specific document data from a result of the document search using each of a plurality of first labels and second labels attached to a plurality of specific document data as a search query. The performance evaluation unit-detects the degradation in performance of the document search when a variation value of the first statistical value due to update of a language model accompanying addition of at least one piece of document data is larger than a first threshold, and when a variation value of the second statistical value due to update is larger than a second threshold.
A gas chromatograph mass spectrometer includes a gas chromatograph part including a separation column, a mass spectrometer part, and a controller configured to control at least an ionization part of the mass spectrometer part. The ionization part includes an ion source box having a space for ionizing the components flowing out from an outlet of the separation column in the inside, a heater for adjusting a temperature of an ion source box, and a filament that is arranged outside of the ion source box and generates an electron for ionizing the components flowing out from the outlet of the separation column. The controller is configured to, after applying voltage to the filament, adjust a temperature of the ion source box affected by heat emitted from the filament to a predetermined temperature by controlling output of the heater in relation to magnitude of heat generation of the filament.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
H01J 49/14 - Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
National University Corporation Tokai National Higher Education and Research System (Japan)
Inventor
Ikehara, Tatsuya
Furumiya, Tetsuo
Tojo, Koji
Tomita, Hideki
Abstract
A gas measurement apparatus includes an optical resonator that resonates light, a light source that generates light for irradiation of the optical resonator, and a photodetector that detects light taken out of the optical resonator. The optical resonator includes a plurality of mirrors, a holding member, a hollow tubular member, a hollow tubular member, and a temperature adjustment instrument. The holding member is lower in thermal expansion coefficient than the hollow tubular member. The hollow tubular member includes a portion higher in thermal conductivity than the holding member and a bellows higher in elasticity than a first portion. The hollow tubular member is equal to or higher than the hollow tubular member in thermal conductivity, and is provided as far as positions of the plurality of mirrors on an inner side of the bellows.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
71.
DEFECT DETECTION DEVICE AND DEFECT DETECTION METHOD
In a defect detection device (10), an input receiver (161) receives an input, by a user, of information concerning the kind and size of a defect expected to be present in or on a test object. An exciter (11, 12) induces an elastic wave in the test object, with the frequency of the elastic wave being variable. A measurer (15) optically measures a vibration state of the surface of the test object caused by the elastic wave. A wavelength determiner (164) determines the wavelength of the elastic wave induced in the test object, based on the vibration state obtained by the measurer. A frequency selector (165) selects an appropriate frequency from a plurality of frequencies, based on the kind and size of the expected defect as well as the wavelength acquired for each of the plurality of frequencies by the wavelength determiner by varying the frequency of the elastic wave.
A chromatograph mass spectrometer includes a measurement unit including a mass spectrometry unit capable of MSn analysis, and to separate sample components and repeatedly perform mass spectrometry, a chromatogram display processing unit to create a chromatogram at a specific m/z and display it, a time designation unit to designate a retention time according to a user operation, a spectrum display processing unit to create an MS spectrum corresponding to the retention time and an MSn spectrum, as an MSn analysis result corresponding to the retention time, targeting an m/z of a peak in the MS spectrum or an m/z range including the m/z, and display the MS spectrum and the MSn spectrum on the same screen, the time designation section designating a retention time by a user moving a pointer, and the spectrum display processing unit, updating the display corresponding to the retention time corresponding to the pointer position.
An automatic sample injection device is provided with a vial placement unit (2) configured to place a vial (10) thereon, a sampler (6) provided at a position different from a position of the vial placement unit (2), the sampler being configured to collect a liquid from the vial (10), a conveyance unit (4) provided with a gripper (14) for gripping the vial (10) from above, the conveyance unit being configured to convey the vial (10) between the vial placement unit (2) and the sampler (6), a target position setting unit (22) configured to execute a teaching mode for setting a target position at which the gripper (14) is to be placed when placing the vial (10) at a predetermined position, cause a user to perform positioning of the gripper (14) to a position to be the target position in the teaching mode, and set a position of the gripper (14) positioned by the user as the target position, and a control unit (20) configured to position the gripper (14) at the target position set by the target position setting unit (22) when placing the vial (10) at the predetermined position. The target position setting unit (22) is configured to execute, in the teaching mode, an auxiliary operation for visually assisting positioning of the gripper by the user when causing the user to perform positioning of the gripper (14) to a position to be the target position.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
An X-ray analyzer includes a sample container for accommodating a sample, a placement portion capable of placing the sample container thereon, an X-ray irradiation source for irradiateing the sample with X-rays from below the placement portion, a detector for detecting fluorescent X-rays generated from the sample below the placement portion, and a holder placed on the placement portion, and configured to accommodate the sample container. The placement portion has an opening. The sample container includes a container body for surrounding the sample, the container body beings having a shape opened downward, and a container film configured to close an opening of the container body and support the sample. The holder includes an enclosure cylinder having an outer shape larger than the opening, the to surround the sample container, and having a shape opened downward, and a holder film closing an opening of the enclosure cylinder.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
G01N 23/2204 - Specimen supports therefor; Sample conveying means therefor
75.
ELECTROPHORESIS SYSTEM, ELECTROPHORESIS APPARATUS, AND ELECTROPHORESIS ANALYSIS METHOD
This electrophoresis system includes an electrophoresis apparatus, an analysis apparatus, and a display unit. Then, in a case where at least one of an apparatus error that is an abnormality in the electrophoresis apparatus or an analysis error that is an abnormality in the analysis of a component of the object-to-be-measured is detected, the analysis apparatus is configured to display, on the display unit, an abnormality detection indication that allows identification of the type of the detected abnormality.
An X-ray imaging apparatus is provided with an X-ray irradiation unit, a detector, an image generation unit, an optical imaging unit for capturing an optical image, a storage unit for storing a trained model, the trained model being configured to output determination information to an input image based on the optical image, the determination information determining a state regarding an imaging range of a predetermined site of the subject or a relative position of the predetermined site to the other site of the subject, a control unit for acquiring the determination information, using the trained model, and a notification unit.
This electrophoresis system includes an electrophoresis apparatus, an analysis apparatus, and a display unit. The analysis apparatus is configured to switch between a detailed display state in which a plurality of analysis result check displays including at least the gel image display are displayed in a result display area of the display unit and an enlarged display state in which only the gel image display among the plurality of analysis result check displays is enlarged and displayed in the result display area of the display unit.
G02F 1/167 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on translational movement of particles in a fluid under the influence of an applied field characterised by the electro-optical or magneto-optical effect by electrophoresis
A cell culture system includes: a first pump; and a first cell culture container and a second cell culture container. The first cell culture container has a first culture medium circulation flow path. The second cell culture container has a second culture medium circulation flow path independent of the first culture medium circulation flow path. The first culture medium circulation flow path and the second culture medium circulation flow path are fluidly connected to the first pump.
KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (Japan)
Inventor
Ueno, Morio
Hamuro, Junji
Yoshii, Kengo
Sotozono, Chie
Sonomura, Kazuhiro
Sato, Taka-Aki
Abstract
A method for diagnosing the risk of glaucoma development, which can diagnose the risk of glaucoma development at the pre-disease stage, and to provide a new method to diagnose disease progression in the end-stage glaucoma. The method can include, for example, a diagnosing method for the risk of an ocular disease development or for the disease progression of an end-stage ocular disease by molecular profile analysis of the ocular anterior tissue microenvironment, comprising a step of measuring the concentration level of a metabolite appearing in the collected aqueous humor specimens by mass spectrometry (MS).
A sample purification apparatus includes a container for separating, with a heavy solution, a mixed sample based on a specific gravity difference and a collector that collects a component in the mixed sample lighter in specific gravity than the heavy solution by receiving a supernatant flowed out from the container. The container includes a flow-out port provided in an uppermost portion of the container and a flow-out path that guides the supernatant flowed out through the flow-out port to the collector. the container has a horizontal cross-sectional area which gradually decreases upward starting from a prescribed height of the container to a height where the flow-out port is located.
Provided is a gas chromatograph capable of efficiency circulating air in a column oven. The gas chromatograph is provided with a column oven, a heater, a fan, and a cylindrical member. The column oven accommodates a column. The heater heats the inside of the column oven. The fan has a blade that rotates about a rotation axis in the column oven, and sends air toward the column provided in the axial direction that is a direction along the rotation axis. The cylindrical member is arranged to accommodate at least a part of the fan in a state of being spaced apart from the column in the axial direction and surrounding an outer periphery of the fan along a rotational direction of the blade.
A mode of a chromatograph mass spectrometer configured to collect chromatograph mass spectrometry data by repeatedly performing MS analysis and MS/MS analysis or only MS/MS analysis according to a predetermined condition in the mass spectrometer unit on a sample containing a compound separated by a chromatograph unit; a scatter diagram creation section (45) configured to create, based on the data collected by the measurement unit, a scatter diagram in which a retention time and a mass-to-charge ratio of precursor ions are set to axes orthogonal to each other and positions or ranges of the precursor ions from which MS/MS spectra are acquired are plotted; a spectrum creation unit (46) configured to create MS/MS spectra corresponding to the precursor ions indicated on the scatter diagram; and a display processing unit (48) configured to display the scatter diagram and the MS/MS spectra together on a screen of a display unit.
To provide a method for discriminating a microorganism by selecting and using a marker protein capable of reproducibly and quickly discriminating a bacterial species of the genus Listeria. The method for discriminating a microorganism according to the present invention includes: a step of subjecting a sample containing a microorganism to mass spectrometry to obtain a mass spectrum; a reading step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum; and a discrimination step of discriminating which bacterial species of Listeria bacteria the microorganism contained in the sample contains based on the mass-to-charge ratio m/z, in which at least one of 17 ribosomal proteins L3, L4, L23, L2, L24, L6, L18, S5, L15, S13, S11, L10, L21, L13, S9, L31, S16 is used as the marker protein and particularly at least one of 8 ribosomal proteins L24, L6, L18, L15, S9, L31, S16 among the 17 ribosomal proteins is used.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
The present mass spectrometer has one or more intermediate vacuum chambers between an ion source to generate ions derived from a sample component in an atmospheric pressure atmosphere and a vacuum chamber where a mass separator is arranged, including an ion transport unit to have an ion outlet in a first intermediate vacuum chamber at a subsequent stage of the ion source and send ions to the first chamber, an exhaust opening portion to evacuate the first chamber, which is provided in front of ion flow discharged from the ion outlet into the first chamber, an ion delivery opening portion to send ions to a next stage, which is provided on a line intersecting a straight line connecting the ion outlet and the exhaust opening portion, and an ion guide to guide ions to the ion delivery opening portion by an action of a radio-frequency electric field.
An X-ray imaging apparatus reduces waiting time and smoothly performs position alignment with a target region. The X-ray imaging apparatus has a C-arm that supports an X-ray tube and an X-ray detector; a turning mechanism that turns the C-arm around the vertical axis AX2; a table on which a subject M is loaded; a console; and a control element, wherein the control element runs the turning mechanism to turn the C-arm in the direction toward the preset target angle when the console provides the input power to perform the relative move of the table relative to the C-arm.
Provided is a centrifugal field-flow fractionation device capable of suppressing deformation of a channel member. Pressure in a channel formed inside the channel member in a centrifugal field-flow fractionation device 1 is increased by a pressure increasing mechanism 8 provided downstream of the centrifugal field-flow fractionation device 1. In this manner, an inner surface of the channel is pressed outward by a liquid sample in the channel, and an outer peripheral surface and an inner peripheral surface of the channel member can be suppressed from being recessed toward the channel side.
B04B 1/02 - Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles without inserted separating walls
B03B 5/32 - Washing granular, powdered or lumpy materials; Wet separating by sink-float separation using heavy liquids or suspensions using centrifugal force
B04B 11/02 - Continuous feeding or discharging; Control arrangements therefor
B04B 13/00 - Control arrangements specially designed for centrifuges; Programme control of centrifuges
87.
PEAK TRACKING DEVICE, PEAK TRACKING METHOD AND PEAK TRACKING PROGRAM
A peak tracking device includes a chromatogram acquirer that acquires chromatograms based on measurement data pieces obtained from measurements by an analyzer in accordance with analysis condition data pieces, a score calculator that calculates score data based on a belonging probability, the probability being calculated for each peak appeared in each chromatogram to belong to one of substances included in a sample, and a score displayer that displays on a display the score data calculated by the score calculator.
A concentrator includes a casing, a separation membrane that sections an inner space of the casing to form a flow path in the casing, a first supplier that supplies a first liquid from a first position of the casing to the flow path such that the first liquid flows along the separation membrane in a first direction, a second supplier that supplies a second liquid from a second position of the casing to the flow path such that the second liquid flows along the separation membrane in a second direction opposite to the first direction, and a third supplier that supplies a third liquid including a target component having a size that does not allow permeation of the target component through the separation membrane from a third position of the casing to the flow path.
This X-ray imaging apparatus (100) is provided with an X-ray irradiation unit (2), an X-ray detection unit (3), a pulse width setting unit (72) for setting a pulse width of X-rays to be emitted, an X-ray irradiation control unit (71) for causing the X-rays to emit from the X-ray irradiation unit (2), an X-ray image generation unit (73) for generating an X-ray image (10), and a device detection unit (74) for detecting, based on a trained model (80) generated by machine learning, the device (200) reflected in the X-ray image (10). The pulse width is a blur suppression pulse width equal to or less than a pulse width at which detection accuracy of detecting the device (200) based on the trained model (80) is maximized.
An integrated viewer for multiple measurements according to a first aspect includes: a storage unit that stores, for each of a plurality of types of analyzers, a type of a feature amount obtained from a measurement result of the analyzer; a display control unit that displays types of feature amounts stored in the storage unit on a display screen in a selectable manner; and a registration unit that names and registers a set of types of feature amounts selected by an operator among the types of the feature amounts. The display control unit displays, side by side on the display screen, a first display region in which the type of the feature amount is displayed in a tab for each type of the analyzers and a second display region in which the set of types of the feature amounts selected by the operator is displayed.
This X-ray phase imaging system includes a plurality of gratings including a first grating that is irradiated with X-rays from an X-ray source and a second grating that is irradiated with X-rays from the first grating. The X-ray phase imaging system includes an imaging unit that optically images a subject and one or both of the first grating and the second grating.
A column oven is provided with an inner casing forming an inner space therein, the inner space being configured to adjust a temperature of a separation column for gas chromatography in a state in which the separation column is accommodated in the inner space, a temperature control element provided in the inner space to adjust the temperature of the inner space, and a heat insulation material layer surrounding an outer peripheral surface of the inner casing, the heat insulation material being composed of a fibrous material. The heat insulation material layer includes a first layer having a first bulk density ρ1 and a second layer enclosing an outer side of the first layer, the second layer having a second bulk density ρ2 smaller than the first bulk density ρ1.
In a Raman microscope, a depth measurement processor performs depth measurement by changing a focal position of laser light along a depth direction of a sample which is an irradiation direction of the laser light with respect to the sample, and meanwhile, acquiring a Raman spectrum of the sample at a plurality of points in the depth direction. A display processor displays an input screen used to input a parameter at a time of performing the depth measurement on the sample in association with a surface image of the sample on a stage. The parameter includes a range in which the focal position of the laser light is changed along the depth direction and an interval between the plurality of points within the range.
A viewer for analysis includes: a communication unit for receiving analysis results for each of a plurality of samples, the analysis results being different in type from each other and outputted from a plurality of types of analyzers; a display unit for displaying the analysis results received by the communication unit; a control unit for controlling the display unit; and a first selection means for selecting at least two or more display target samples from the plurality of samples. The display unit includes a display area for displaying the analysis results by the plurality of types of analyzers for each of the at least two or more display target samples; and a list display area for displaying at least two or more display areas in a list, the at least two or more display areas corresponding to the at least two or more display target samples.
G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
An ion analyzer 2 including: a power feeding circuit 26 in which a power supply connection part 261, a first electrode connection part 262, a first resistance element 263, a second electrode connection part 264, a second resistance element 265, and a grounding part are provided in series; a power supply P connected to the power supply connection part 261 and configured to output both a DC positive voltage and a DC negative voltage; a first voltage supply electrode 23 connected to the first electrode connection part 262; and a second voltage supply electrode 24 connected to the second electrode connection part 264. In particular, it can be suitably used as a device for applying a voltage to a push electrode 23 and a convergence electrode 24 disposed in an ionization chamber 20 of a mass spectrometer including an ESI source 21.
An ion analyzer 1 including: a first member 16 fixed to an ion outflow port and provided with a fixing pin 1621 on one side and a pin hole 1631 on the other side sandwiching the ion outflow port; a second member 12 to be fixed to the first member and including an ion flow controller 121 configured to control movement of ions flowing out from the ion outflow port, the second member having a first concave part 1231 configured to engage with the fixing pin from a first direction perpendicular to an axis of the fixing pin, and a second concave part 1241 configured to engage with an insertion pin to be inserted into the pin hole from a second direction different from the first direction; and a pin member 17 having an insertion pin 172 inserted into the pin hole and a head part 171 configured to sandwich and fix the second concave part with the first member.
Provided is a method for analyzing a sample containing a sialic-acid-containing glycan including a sialic-acid-linkage specific modification, based on mass spectrum data of the sample, including steps of: detecting, from the mass spectrum data, a representative peak for each isotope peak cluster; detecting, from the representative peaks, an isomer peak cluster including multiple ion peaks estimated to be identical in the number of sialic acids and the glycan composition exclusive of the sialic acids; estimating a glycan composition for each representative peak according to predetermined glycan search conditions; creating a mass spectrum with an annotation added for each isomer peak cluster to indicate a correspondence between each peak in one cluster and a peak in a mass spectrum, and displaying the annotated mass spectrum on a display section; and creating a table relating each estimated glycan-composition candidate to an isomer peak cluster, and displaying the table on the display section.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
In a Raman microscope, a depth measurement processor performs depth measurement by changing a focal position of laser light along a depth direction of a sample which is an irradiation direction of the laser light with respect to the sample, and meanwhile, acquiring a Raman spectrum of the sample at a plurality of points in the depth direction. The display processor causes Raman spectra obtained at the plurality of points by the depth measurement to be displayed. The display processor can display a surface image of the sample on the stage and a depth image representing a plurality of points in the depth direction and causes, in a case where at least one point of the plurality of points in the depth image is selected, the Raman spectrum corresponding to the at least one point to be displayed.
Provided is a method for analyzing a sample containing a sialic-acid-containing glycan including a modification specific to a sialic-acid linkage type. A representative peak is detected from mass spectrum data of a sample for each isotope peak cluster. For each representative peak, a glycan composition is estimated according to a specified glycan search condition, and a glycan-composition candidate is determined. From the representative peaks, an isomer peak cluster including peaks estimated to be identical in the number of sialic acids and the glycan composition exclusive of the sialic acids is detected. The candidates are narrowed down by applying, to each peak in the isomer peak cluster, predetermined constraint conditions concerning the number of sialic acids contained, number of sialic-acid linkage types, kinds of sialic acids, and identity of the glycan composition exclusive of the sialic acids. A candidate list, with visual discrimination between the selected and unselected candidates, is displayed.
An LC system includes a liquid delivery checker configured to execute a liquid delivery check mode of setting a predetermined flow rate to a liquid delivery pump and operating the liquid delivery pump at a timing different from analysis of a sample in order to check a liquid delivery flow rate of the liquid delivery pump, and a measuring instrument for measuring an amount of a mobile phase delivered by the liquid delivery pump during the liquid delivery check mode. The liquid delivery checker is configured to obtain an actual measurement value of a flow rate of a mobile phase when operating the liquid delivery pump by setting the predetermined flow rate to the liquid delivery pump using a measurement value obtained by the measuring instrument in the liquid delivery check mode.
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