A GC assistance device includes a saving amount evaluator, a consumption amount evaluator and an outputter, and is used together with a gas chromatograph. The saving amount evaluator evaluates a saving amount of a resource caused by stopping of the gas chromatograph. The consumption amount evaluator evaluates a consumption amount of the resource caused by recovery of the gas chromatograph from a stop state. The outputter presents an evaluation value in regard to the saving amount and the consumption amount to a user. Alternatively, the outputter controls an operation state of the gas chromatograph based on the evaluation value.
A flow rate switching mechanism including: a first section including: a first housing with a passage internally bored through, the passage having a narrowed portion at a distance from one end of the passage, and the narrowed portion having a smaller cross-sectional area than the cross-sectional area of the passage at the one end; a capillary having an internal passage having a smaller cross-sectional area than the cross-sectional area of the narrowed portion; and a hermetic support member supporting the capillary and to provide a seal; a second section having a second housing identical in shape to the first housing, without having the capillary and the hermetic support member; and a three-way valve being alternatively switchable between a first state in which the outlet end is connected to the first inlet end and a second state in which the outlet end is connected to the second inlet end.
H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures
F25B 41/42 - Arrangements for diverging or converging flows, e.g. branch lines or junctions
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
3.
QUALITY CONTROL STANDARD SOLUTION USED IN PEPTIDE ASSAY, AND QUALITY CONTROL OF PEPTIDE ASSAY
A quality control standard for peptide (including protein) measurement, and a quality control for peptide (including proteins) measurement are provided. A QC standard sample for measurement of a target peptide, the QC standard sample comprising: a blood sample comprising a peptide, and a peptide labeled with a stable isotope that is spiked into said blood sample. The target peptide to be measured includes, for example, at least one selected from the group consisting of Aβ1-42 (SEQ ID NO.: 9), Aβ1-38 (SEQ ID NO.: 11), Aβ1-40 (SEQ ID NO.: 7), and APP669-711 (SEQ ID NO.: 10). The peptide labeled with a stable isotope that is spiked into the blood sample includes, for example, at least one selected from the group consisting of SIL-Aβ1-42, SIL-Aβ1-38, SIL-Aβ1-40, and SIL-APP669-711.
An air measurement method of performing measurement by injecting air into a gas chromatograph includes a liquid suction step of sucking a liquid that does not interfere with detection of a predetermined component in air by a gas chromatograph into a syringe to fill the syringe with the liquid, an air suction step of sucking a predetermined amount of air into the syringe after the liquid suction step, an injection step of injecting the predetermined amount of air sucked into the syringe into the gas chromatograph after the air suction step, and a recording step of acquiring a detection signal for the air injected into the gas chromatograph in the injection step and recording an acquired detection signal in association with the air injection amount into the gas chromatograph.
A time-of-flight mass spectrometry device includes an electrode to which a DC high voltage is applied in order to form an ion flight space and a high voltage power supply device that applies the high voltage to the electrode. The high voltage power supply device includes a high voltage generating circuit that generates the high voltage, and a voltage control circuit that is selectively set to a convergence responsiveness priority mode in which the high voltage generating circuit is controlled such that the high voltage has first convergence responsiveness and first stability or a stability priority mode in which the high voltage generating circuit is controlled such that the high voltage has second convergence responsiveness that is lower than the first convergence responsiveness and second stability that is higher than the first stability.
An estimation device (200) generates quality prediction data (540) indicating a quality of a drug substance of a biopharmaceutical manufactured by culturing cells, by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance in a culturing vessel at least one timing after a predetermined time period has passed since the cells have been seeded in a medium. The prediction model (420) is generated by executing a learning process using training data (530) that includes measurement data including a measurement result obtained by measuring a substance in a culturing vessel at a plurality of timings after seeding of the cells in the medium, and quality data obtained by analyzing a drug substance of the biopharmaceutical manufactured from the cells.
A biochemical analysis apparatus includes a piercer for piercing a cover member, a nozzle that passes through the piercer which has pierced the cover member and suctions a specimen, a liquid surface sensor that detects contact of the nozzle with the specimen, and a controller that drives the nozzle and the piercer, in which the controller provides an error notification upon detection of contact of the nozzle with the accommodation object inside the piercer, and upon detection of a collision of the nozzle with the cover member.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
8.
METHOD FOR ANALYZING DATA ACQUIRED BY MALDI MASS SPECTROMETRY, DATA-PROCESSING DEVICE, MASS SPECTROMETER, AND DATA-ANALYZING PROGRAM
A method for analyzing MALDI mass spectrometry data includes: calculating m/z values respectively corresponding to peaks in amass spectrum, from data corresponding to the mass spectrum acquired by MALDI mass spectrometry performed on a sample; and performing at least one of calculations (a) and (b), based on the m/z values and information on kinds of ions possibly generated from the sample in the mass spectrometry, where calculation (a) includes assuming that ions respectively corresponding to the peaks are first ions singly charged, and calculating m/z of second ions respectively corresponding to the first ions and being multiply charged, and calculation (b) includes assuming that ions respectively corresponding to the peaks are first ions that are multiply charged ions, and calculating m/z of second ions respectively corresponding to the first ions and being singly charged.
A calibrant for use in correction of machine difference of mass spectrometers and a method for producing the calibrant are provided. A calibrant for use in a mass spectrometer, the calibrant comprising not less than two calibration substances, wherein a ratio of, relative to a concentration of one calibration substance of the not less than two calibration substances, a concentration of another calibration substance of the not less than two calibration substances is a predetermined value, and a method for producing the calibrant.
A power supply device applies a voltage to a quadrupole mass filter. The power supply device has a main substrate and a wave-detection substrate. The main substrate includes a detector. The wave-detection substrate includes a wave detector and an identifier. The wave detector detects an AC component of a voltage to be applied to the quadrupole mass filter as a wave-detection voltage. The identifier outputs identification information of the wave detector defined in correspondence with the configuration of a rectifying device of the wave detector. The detector detects identification information output by the identifier, and supplies the detected identification information to a corrector that corrects a deviation of voltage caused by a leakage current of the rectifying device.
A mass spectrometer includes: a first ion guide disposed in a first intermediate vacuum chamber; a first partition wall portion which constitutes at least a part of a partition wall separating the first intermediate vacuum chamber and a second intermediate vacuum chamber and has an ion passage hole; a second ion guide disposed in a second intermediate vacuum chamber; a second partition wall portion which constitutes at least a part of a partition wall which is a subsequent stage of the second intermediate vacuum chamber and has an ion passage hole; a first holding portion configured to integrally hold the first ion guide and the first partition wall portion; a second holding portion configured to hold the second ion guide; a coupling portion detachably connecting the first holding portion and the second holding portion; and a vacuum chamber main body portion to which an ion transport unit is detachably mounted.
An X-ray phase imaging apparatus includes an X-ray source; a detector; a plurality of gratings; a rotation mechanism; an image processor configured to generate a phase contrast image and to generate a preview image prior to capture of the phase contrast image; and a controller configured to control function of displaying on a display the preview image, and function of discriminatively displaying on the display an image coverage area for the phase contrast image that is associated with a relative rotation angle between the plurality of gratings and a subject.
G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers
G01N 23/046 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
G01N 23/201 - Measuring small-angle scattering, e.g. small angle X-ray scattering [SAXS]
14.
X-RAY PHASE IMAGING APPARATUS AND X-RAY PHASE IMAGING METHOD
An X-ray phase imaging apparatus includes a control device configured or programmed to make a notification prompting a user to update or generate a corresponding second X-ray image when determining that a decrease in an image quality of an X-ray phase contrast image generated based on a first X-ray image obtained by imaging a subject and a second X-ray image obtained by imaging without the subject arranged does not fall within a predetermined allowable range and/or determining that the second X-ray image associated with an imaging condition has not been stored.
G01N 23/041 - Phase-contrast imaging, e.g. using grating interferometers
G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays
15.
GAS CHROMATOGRAPH AND CARRIER GAS USAGE AMOUNT DISPLAY METHOD
A gas chromatograph includes a sample gas generator, a separation column configured to separate components of an introduced sample gas, a gas supply source configured to supply a carrier gas to the sample gas generator to carry the sample gas from the sample gas generator to the separation column when the components of the sample gas are analyzed, a controller configured or programmed to acquire an in-analysis usage amount of the carrier gas based on an analysis time for analyzing the components of the sample gas, and a flow rate of the carrier gas supplied from the gas supply source to the sample gas generator, and a display configured to display the in-analysis usage amount acquired by the controller.
An X-ray phase imaging apparatus includes an X-ray source; a detector; a plurality of gratings; an image processor configured to generate two or more types of first phase contrast images selected from absorption, differential phase and dark-field images as preview images under an imaging condition simpler than an imaging condition for a second phase contrast image to be captured in actual imaging; and a controller configured to display the first phase contrast images on a display.
First product ion spectrum data is acquired by dissociating a precursor ion derived from a sample component by collision between the precursor ion and an inert gas molecule to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; second product ion spectrum data is acquired by dissociating the precursor ion by a reaction of the precursor ion with hydrogen radicals to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; and a set of product ions having a predetermined mass difference is extracted in the first product ion spectrum data and the second product ion spectrum data.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/26 - Mass spectrometers or separator tubes
Provided is a signal processing device for X-ray analysis capable of suppressing effects of increased background due to pile-up signals and suppressing the dead time from lengthening. A signal processing device for X-ray analysis includes a differentiating circuit configured to convert a plurality of staircase wave signals detected by the X-ray detector into differential wave signals, a digital filter configured to convert the differential wave signals into trapezoidal wave signals or triangular wave digital signals, and a peak detection unit configured to discriminate and count a peak value extracted from a peak portion of the trapezoidal wave signal or the triangular wave signal. The peak detection unit is set such that a rising threshold Tu to be compared with a signal of the rising-side sloped line segment and a falling threshold Td to be compared with a signal of the falling-side sloped line segment in the trapezoidal signal or the triangular wave signal have a relation of Tu>Td. The peak detection unit selects the trapezoidal signal or the triangular wave signal to be counted from the converted trapezoidal signal or the converted triangular wave signal based on the rising threshold Tu, and terminates detection of the peak portion of the trapezoidal signal or the triangular wave signal based on the falling threshold Td.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
A Raman infrared compound microscope device includes: a first light source that generates laser light; a second light source that generates infrared light; a third light source that generates visible light; and a first optical system. The first optical system orients the visible light having reached the first optical system in different directions between when performing a Raman analysis using Raman light generated from a sample by irradiation of the laser light and when performing a first infrared analysis using the infrared light having passed through the sample.
The present invention provides a method for mass spectrometry of a negatively charged organic synthetic compound, and a matrix that can be used in said method. A method for mass spectrometry of a negatively charged organic synthetic compound, the method comprising using, as a liquid matrix, an ionic liquid comprising an amine ion and an acidic group-containing organic substance ion. For example, the amine is 3-aminoquinoline (3-AQ), and the acidic group-containing organic substance is p-coumaric acid (p-CA). The negatively charged organic synthetic compound to be analyzed is, for example, an organic synthetic polymer compound or a complex compound.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
G01N 30/84 - Preparation of the fraction to be distributed
An automatic dispensing device includes a gripper configured to grip a dispenser having a discharge nozzle with the discharge nozzle facing downward, a tip rack arrangement portion configured to arrange a tip rack in which pipette tips to be attached to the discharge nozzle are accommodated, a biasing member configured to bias the tip rack arrangement portion from below, and a moving unit configured to move the gripper relative to the tip rack arrangement portion.
A sheet-like diaphragm made from a non-metallic material, a main body block made from a non-metallic material, having a diaphragm facing surface facing a main plane of the diaphragm, disposed in a manner that the diaphragm facing surface is covered by the diaphragm, and provided with a fluid outlet and a fluid inlet facing the diaphragm side, a sensor head that has a recess for accommodating pressure transmission liquid, is disposed on a side opposite to the main body block across the diaphragm such that an opening of the recess is closed by the diaphragm, and is configured to detect pressure of fluid flowing between the diaphragm and the diaphragm facing surface by a deformation amount of the diaphragm are included. The fluid inlet and the fluid outlet are provided in a manner separated from the diaphragm further than the diaphragm facing surface.
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
A chromatograph including: a column 13 configured to separate a compound contained in a sample; a detection unit 2 configured to measure a predetermined physical quantity of the compound flowing out of the column; a measurement condition storage unit 411 in which one or a plurality of measurement conditions are stored; a measurement control unit 423 configured to set an operation of measuring each of a plurality of samples using any one of the measurement conditions stored in the measurement condition storage unit a plurality of times for each sample and execute all measurement operations set for the plurality of samples in random order; and a measurement data processing unit 424 configured to associate measurement data acquired by the detection unit with a sample to be measured for each measurement.
Provided is an X-ray fluorescence analyzer capable of performing an analysis under more favorable conditions depending on an analysis target. The X-ray fluorescence analyzer includes a detector 30, preamplifiers 41A, 41B configured to amplify a detection signal from the detector into a staircase wave signal at different signal amplification factors GA, GB, a differentiating circuit 42 configured to convert the staircase wave signal into a differential wave signal, an A/D converter 43 configured to convert the differential wave digital signal to a digital signal, a signal processing unit 160 configured to detect a peak value from the digital signal, discriminate and count the peak value, and generate a histogram, and an input unit 51 configured to set the energy range of the fluorescent X-rays to be analyzed. Any one of the preamplifiers is automatically selected based on maximum energy in the set energy range.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
26.
METHOD FOR DRIVING LINEAR ION TRAP AND MASS SPECTROMETER
A method for driving a linear ion trap having rod electrodes arranged so as to surround a central axis includes: an ion-introducing step for introducing ions into an ion-capturing space surrounded by the rod electrodes, and for capturing the ions by a multipole RF electric field created within the ion-capturing space; and an ion-ejecting step for creating both a DC electric field for ion extraction extending from an external area outside the ion-capturing space into the ion-capturing space through a space between two predetermined rod electrodes neighboring each other around the central axis among the plurality of rod electrodes and the multipole RF electric field, and for sequentially ejecting ions according to their m/z from the ion-capturing space toward the external area through the space between the two predetermined rod electrodes by changing at least one of the multipole RF electric field and the DC electric field.
An automatic dispensing device is provided with a sample container holder having a plurality of recesses, each of the recessed being configured to accommodate a sample container, a biasing member provided in each of the plurality of recesses, the biasing member being configured to bias the sample container accommodated in the recess upward, and a liquid dispensing mechanism having a discharge pipe for discharging a liquid from a tip end, the liquid dispensing mechanism being configured to discharge the liquid in a state in which the tip end of the discharge pipe is pressed against an inner part of the sample container at a predetermined dispensing target position from above.
An analyzer that analyzes one or more pieces of data acquired by electrophoresis separation of a sample includes a memory, a display unit, and a processor. The memory stores the one or more pieces of data. The display unit displays, based on the one or more pieces of data, a gel image, an electropherogram, a first size guide corresponding to the gel image, and a second size guide corresponding to the electropherogram. When the first size guide is located at a first position corresponding to a specific value associated with a size in the gel image, the processor displays a second size guide at a second position corresponding to the specific value in the electropherogram.
G06F 3/04845 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range for image manipulation, e.g. dragging, rotation, expansion or change of colour
A quadrupole mass spectrometer includes a quadrupole mass filter including: a main rod portion including four main rod electrodes; a pre-rod portion including four pre-rod electrodes, where, at an end opposite to the main rod portion, the four pre-rod electrodes are disposed to be aligned on an inscribed circle having the same radius centered on the ion optical axis, and, at the other end facing the main rod portion, two pre-rod electrodes facing each other across the ion optical axis and the other two pre-rod electrodes are disposed to be aligned on an inscribed circle having different radii centered on the ion optical axis; a main voltage applying unit to apply, to each main rod electrodes, a voltage created by superimposing a DC voltage and an RF voltage; and a pre-voltage applying unit to apply an RF voltage having a same frequency as the RF voltage to each pre-rod electrodes.
A microchannel device includes an opening that receives a test solution, a main channel that communicates with the opening, and a collection portion provided at an outlet-side end of the main channel. The collection portion includes a pool that stores the test solution, a connection channel that connects the pool with the outlet-side end, and a protrusion that is arranged in the connection channel to generate air bubbles between the protrusion and an inner wall of the connection channel to close the connection channel, upon receiving the test solution discharged from the main channel.
An ion transport optical system includes N rod electrodes forming an N-pole arrangement externally tangent to a circle of diameter A1 at an ion-entrance end, where N is an even number not smaller than six. Four electrodes form a quadrupole arrangement externally tangent to a circle of diameter A2 at an ion-exit end, where A2
Provided is a non-transitory computer-readable medium storing a program for causing a computer to execute the steps including a step of subjecting a sample containing microorganisms to mass spectrometry to obtain a mass spectrum, a step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum, and an identification step of identifying which bacteria of serovar of Salmonella genus bacteria the microorganisms contained in the sample contain, based on the mass-to-charge ratio m/z, wherein at least one of two types of ribosomal proteins S8 and Peptidylpropyl isomerase is used as the marker protein.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
An ion chromatography analysis system includes a system monitoring part being configured to detect an abnormality, to determine, based on a fluctuation rate in a certain time of the predetermined state of a most recent of the monitor value, whether the fluctuation is a short-term fluctuation that occurs in a short term or a long-term fluctuation that occurs in a long term, and to identify a cause of the abnormality by using whether the fluctuation is the short-term fluctuation or the long-term fluctuation.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
G01N 30/14 - Preparation by elimination of some components
A cell culture container includes: an insert member having a membrane on which a cell is seeded, the insert member defining a first inner space that functions as an anaerobic chamber; a container having an attachment/detachment portion to and from which the insert member is attachable and detachable, the container defining a second inner space that functions as an aerobic chamber; a sealing member that closes an opening of the aerobic chamber between the attachment/detachment portion and the insert member with the insert member being attached to the attachment/detachment portion; and a transfer mechanism that transfers force to the sealing member. The sealing member closes the opening in response to an input of the force from the transfer mechanism.
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (Japan)
AJINOMOTO CO., INC. (Japan)
Inventor
Horie, Shinnosuke
Fujito, Yuka
Hasunuma, Tomohisa
Yoshida, Takanobu
Urahata, Erika
Abstract
Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.
A method of assessing a probe by measuring a known sample whose shape is known with the probe in an electronic microscope, the known sample having a projection part on a surface thereof, and the projection part having a shape tapered toward a vertex thereof, the method comprising a step of measuring circle equivalent radius of the projection part, a step of comparing the circle equivalent radius with a first threshold value, and a step of determining that the probe is satisfactory when the width is less than the first threshold value, and a step of determining that the probe is unsatisfactory when the width is equal to or greater than the first threshold value.
An X-ray imaging system is configured to acquire first and second images from a teacher X-ray image including an inspection target. Discrimination information to discriminate at least one of an area of the inspection target in the first and second images, and an area of a defect part is acquired. Machine learning for producing a learned model is performed by using input teacher data sets based on the first and second images, and output teacher data sets based on the discrimination information.
G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
An object of the present invention is to provide a method for detecting particulate substances with a high degree of sensitivity, while suppressing the generation of non-specific signals. According to the present invention, the generation of non-specific signals in the background can be suppressed by blocking a membrane of a test strip which is used for immunochromatography with a blocking composition including a polymer-based blocking agent having, in its side chain, a substituent represented by the following formula:
An object of the present invention is to provide a method for detecting particulate substances with a high degree of sensitivity, while suppressing the generation of non-specific signals. According to the present invention, the generation of non-specific signals in the background can be suppressed by blocking a membrane of a test strip which is used for immunochromatography with a blocking composition including a polymer-based blocking agent having, in its side chain, a substituent represented by the following formula:
An object of the present invention is to provide a method for detecting particulate substances with a high degree of sensitivity, while suppressing the generation of non-specific signals. According to the present invention, the generation of non-specific signals in the background can be suppressed by blocking a membrane of a test strip which is used for immunochromatography with a blocking composition including a polymer-based blocking agent having, in its side chain, a substituent represented by the following formula:
(wherein R1, R2, and R3 are each independently a hydrogen atom, a C1-6 alkyl group, or a C1-6 hydroxyalkyl group; and n is an integer of 1 to 4), and having a weight average molecular weight (Mw) of 1×103 to 1×107.
Provided is a method of identifying a serovar of Salmonella bacteria including a step of subjecting a sample containing microorganisms to mass spectrometry to obtain a mass spectrum, a step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum, and an identification step of identifying a serovar of Salmonella bacteria in the sample, based on the mass-to-charge ratio m/z, wherein the serovars of Salmonella bacteria are classified using cluster analysis using as an index the mass-to-charge ratio m/z derived from at least 12 types of ribosomal proteins S8, L15, L17, L21, L25, S7, SODa, peptidylprolyl isomerase, gns, YibT, YaiA and YciF as the marker proteins.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
An analysis method includes a humidity measurement step of measuring humidity; a binding step of bringing a sample containing an analyte into contact with a carrier to bind the analyte to the carrier; an elution step of bringing the carrier to which the analyte is bound into contact with an eluate containing a volatile organic solvent to elute the analyte into the eluate; a disposition step of disposing the eluate into which the analyte has been eluted on a measurement plate for mass spectrometry; and a detection step of detecting the analyte by mass spectrometry, in which in the elution step, a use amount of the eluate is determined according to the humidity.
Provided is a quantitative determination method for sulfur compounds in a target group selected from a plurality of groups, e.g., a group including cysteine and related reactive sulfurs, including the steps of: performing an LC/MS/MS measurement of a standard substance having a known concentration of a base compound, e.g., cysteine, in the target group; acquiring quantitative reference information used for quantitative determination of the base compound and other reactive sulfurs, based on the measurement result, assuming that the signal intensities of sulfur compounds in the same group show a predetermined relationship when their concentrations are equal; performing an LC/MS/MS measurement for each sulfur compound in a specimen, under an analysis condition determined beforehand so that the signal intensities of sulfur compounds in the same group show the predetermined relationship when their concentrations are equal; and determining the quantity of each sulfur compound, using the measurement result and quantitative reference information.
An X-ray fluoroscopic imaging apparatus includes an imaging unit, an X-ray image acquisition unit configured to acquire an X-ray image, a target distribution learning identification unit for outputting distribution of a target appearing in an X-ray image using a learning model, an image quality improvement processing unit, and a display unit. The image quality improvement processing unit is configured to switch, using a learning identification result by a target distribution learning identification unit, between a first image processing mode for performing image quality improvement processing on an X-ray image and a second image processing mode for performing image quality improvement processing on the X-ray image without using the learning identification result.
A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
43.
HEALTH RISK REDUCTION METHOD, HEALTH RISK REDUCTION SYSTEM, AND HEALTH RISK REDUCTION PROGRAM
A health risk reduction method includes a step of acquiring physical fitness test data by a physical fitness measurement performed to measure physical fitness of a subject, a step of acquiring cognitive function test data by a cognitive function test of the subject, a step of acquiring exercise content information to be proposed to the subject, based on the physical fitness test data and the cognitive function test data, and a step of outputting the exercise content information to be proposed to the subject.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Provided is a microscopic Raman device including: a first laser light source that generates a first laser light; a second laser light source that generates a second laser light having a wavelength different from a wavelength of the first laser light; a first optical element; a second optical element; a third optical element; a fourth optical element; and a spectrometer. When the first laser light is reflected by the first optical element and passes through the third optical element to irradiate a sample, a first Raman scattered light is generated from the sample. When the second laser light is sequentially reflected by the second optical element, the fourth optical element, and the third optical element to irradiate the sample, a second Raman scattered light is generated from the sample. The first Raman scattered light passes through the third optical element and the first optical element to enter the spectrometer.
In an X-ray imaging, first and second images of X-ray images corresponding to different emission angles are generated. In the X-ray imaging system, based on positions of a target part included in an inspection target in the first and second images, and an angle difference between the emission angles of X-rays that are emitted to generate the first and second images, a three-dimensional position of the target part is calculated by using triangulation.
G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
G01N 23/083 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption the radiation being X-rays
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
Provided is a preparative liquid chromatograph capable of coping with a case where actual second delay time changes after start of a fractionation sequence. When a specific component detected as a peak in both a first detector and a second detector is injected during execution of a fractionation sequence, a control device executes maintenance operation of time difference information stored in an information storage area. In the maintenance operation, the control device executes peak determination as to whether or not a difference between first retention time and second retention time falls within a predetermined allowable range. By the above, the control device checks whether or not the second delay time from when a component is detected by the second detector to when the component reaches a fraction collector changes from a previous state.
An image processing method includes a reconstruction step of reconstructing a radiographic image of a subject by performing reconstruction processing on radiological data of the subject, a count number calculation step of calculating a count number in a subject area in the radiographic image, a standard deviation calculation step of calculating a noise standard deviation in the radiographic image from a relation between the count number in each of a plurality of pre-acquired function calculation radiographic images and the noise standard deviation, by substituting the count number in the subject area into a pre-acquired basic noise deviation function a function in which a value of the count number and a value of the noise standard deviation correspond to each other, and a noise reduction processing step of performing NLM filter processing on the radiographic image using the noise standard deviation calculated in the standard deviation calculation step.
Provided is a mass spectrometer including: a reaction chamber (132) into which a precursor ion is introduced; a radical generation part (54) configured to generate a known radical; a radical supply part (5) configured to react the precursor ion with the radical to generate fragment ions and an adduct ion; a measurement control part (63) configured to measure ions including the precursor ion, the fragment ions, and the adduct ion to obtain a mass spectrum; and an accurate mass estimation part (64) configured to specify a peak of the adduct ion by searching a predetermined mass range centered on a mass value obtained by adding a mass of an atom or molecule derived from the radical to a mass obtained from a peak of the precursor ion, and estimate an accurate mass of the precursor ion by subtracting an accurate mass of the atom or molecule from an accurate mass of the peak.
H01J 49/00 - Particle spectrometers or separator tubes
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
A monitoring device is a monitoring device of a material testing machine including a display having a marker on a display panel. The monitoring device includes: an acquisition unit that acquires a photographed image of a camera that photographs the display panel; a first generation unit that generates a first processed image obtained by gray-scaling the photographed image; a second generation unit that generates a second processed image obtained by performing blur processing on the first processed image; a third generation unit that generates a third processed image obtained by binarizing the first processed image based on the second processed image; and a first detection unit that detects the marker from the third processed image.
Provided is a method of assisting breast cancer diagnosis, comprising: a measuring step for measuring an amount of laminin 5 or laminin β3 in a specimen; and an information-providing step for providing information for breast cancer diagnosis based on the amount of laminin 5 or laminin β3 thus measured. Provided is a test kit for breast cancer comprising an anti-laminin 5 antibody or an anti-laminin β3 antibody.
A novel blood collection instrument with which it is possible to prevent blood from coming into contact with air during collection of blood, and a blood collection plate that is suitably used therefor. A blood collection instrument including: a blood holding member having a structure in which a plurality of plate-shaped members, are overlapped with each other and including a collected blood holding passage formed between overlapped surfaces of the plate-shaped members; a connection part provided at an inflow port of the collected blood holding passage in the blood holding member; and a puncture member including a puncturing hollow needle while being connected to the connection part. An inner hole of the hollow needle of the puncture member is allowed to communicate with the collected blood holding passage in the blood holding member.
An automated analyzer includes: a measurement device; at least one sample tray on which a plurality of sample containers is placed; a conveyance device configured to select one of the plurality of sample containers placed on the sample tray, convey the selected sample container to the measurement device, and return the sample container to an original sample tray on which the sample container was originally placed after measurement by the measurement device; a control device for controlling an operation of the conveyance device; and a retreat portion provided at a position different from positions where the measurement device and the sample tray are provided, the retreat portion being configured to temporarily place the sample container. The control device causes the sample container to retreat to the retreat portion in a case where the sample container cannot be returned from the measurement device to the sample tray.
G01N 23/2204 - Specimen supports therefor; Sample conveying means therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
A mass spectrometer including: a reaction chamber into which a precursor ion derived from a sample molecule is introduced; a collision gas supply part configured to supply collision gas to the reaction chamber; a radical supply part configured to supply hydrogen radicals, oxygen radicals, nitrogen radicals, or hydroxyl radicals to the reaction chamber; a dissociation operation control part configured to control operations of the collision gas supply part and the radical supply part to generate the product ions by collision-induced dissociation and radical attachment dissociation of the precursor ion inside the reaction chamber, an ion detection part configured to mass-separate and detect ions ejected from the reaction chamber, and a spectrum data generation part configured to generate spectrum data based on a detection result by the ion detection part.
An ultraviolet ray emitter includes an inner tube, an outer tube arranged around the inner tube, the outer tube defining between the outer tube and the inner tube, a discharge space where discharge gas is sealed, a pair of electrodes that causes discharge in the discharge space, and an auxiliary light source that assists excitation of discharge gas by emitting light to discharge gas from the outside of the outer tube. The outer tube is less likely to allow passage therethrough of ultraviolet light generated by excitation of discharge gas than the inner tube but allows passage therethrough of light having a wavelength emitted from the auxiliary light source.
A sampling needle (21) is inserted into a sample container (12) by a needle-driving mechanism (23) to collect a sample liquid from the sample container. A depth information acquirer (52) acquires insertion depth information, i.e., a piece of information concerning an insertion depth of the sampling needle into the sample container. A needle-rinsing length setter (54) sets a needle-rinsing length which is an insertion length of the sampling needle into a rinse storage tank (30) having an open top, based on the insertion depth information. A controller (51) controls the needle-driving mechanism so that a portion of the sampling needle extending from the tip of the sampling needle over the needle-rinsing length is inserted into the rinse storage tank. The needle-rinsing length setter is configured to set a shorter needle-rinsing length for a smaller insertion depth of the sampling needle into the sample container, to shorten the needle-cleaning time.
An analysis system includes a gripper arm for conveying a sample container, and a controller for controlling the gripper arm. The gripper arm includes a first gripper and a second gripper for holding the sample container by pinching the sample container, a drive mechanism that changes a size of a gripping space between the first gripper and the second gripper, and a photoelectric sensor for emitting light to the gripping space to detect the light from the gripping space. The controller determines the presence or absence of the sample container in the gripping space based on the presence or absence of a detection signal of the photoelectric sensor.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
58.
CHROMATOGRAPHY QUALITY CONTROL DEVICE AND CHROMATOGRAPHY QUALITY CONTROL METHOD
A chromatography quality control device includes a measurement data acquirer that acquires measurement data obtained as a result of measurement in a chromatograph and stores the measurement data in a storage device, a chromatogram factorizer that retrieves the measurement data from the storage device, dimensionally compresses a chromatogram obtained from the measurement data by factorization and stores component data, the component data obtained by the factorization, in the storage device, and a component data outputter that retrieves the component data from the storage device and outputs the component data to a display device.
A controller (14) slows down and stops a turret (12) when a sensor 33 detects a first detection target portion (31) in a detection area (34). The controller (14) acquires information corresponding to the movement distance (D1) of the first detection target portion (31) from the start of slowdown of the turret (12) to the stop of the turret (12). The controller (14) moves the first detection target portion (31) in a second direction (A2) by the movement distance (D1). The controller (14) moves the first detection target portion (31) in the second direction (A2) to a second position (P6) outside the detection area (34). The controller (14) moves the turret (12) to move the first detection target portion (31) in a first direction (A1) from the second position (P6) to an origin (P0).
A data processing device performs a data process on a measured waveform obtained by a prescribed measurement of a sample. The data processing device includes an estimator, a calculator, and a display processor. The estimator estimates a predictive distribution of each peak shape for a corresponding one of a plurality of peak waveforms using a prescribed peak shape model, the plurality of peak waveforms being included in the measured waveform and being close to each other. The calculator calculates a predictive distribution of a quantitative indicator for each of the plurality of peak waveforms based on the predictive distribution of the peak shape estimated by the estimator. The display processor is operable to display the predictive distribution of the quantitative indicator calculated by the calculator.
In an ionization device for an ionization chamber (11) separated from an analysis chamber (12-14) by a partition wall having an ion introduction port (113), an ionization probe (111) sprays a liquid sample. A heated-gas supply mechanism (112), which includes a gas supply source and a heating section (1122) for heating a gas supplied from the gas supply source, expels the gas in a direction intersecting with the direction in which the liquid sample is sprayed from the ionization probe. A controller (32) controls an operation of the heated-gas supply mechanism so that the gas is continuously expelled from the heated-gas supply mechanism regardless of the presence or absence of an operation by a user while the liquid sample is sprayed from the ionization probe. The continuous expulsion of the gas from the heated-gas supply mechanism prevents this mechanism from being contaminated by the sprayed liquid.
H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
National Cerebral and Cardiovascular Center (Japan)
Inventor
Kawakami, Daisuke
Ihara, Masafumi
Abstract
The present invention chiefly aims to provide a new method of detecting or determining ApoE genetic polymorphism, that is rapid and less invasive to the subject.
The present invention chiefly aims to provide a new method of detecting or determining ApoE genetic polymorphism, that is rapid and less invasive to the subject.
The present invention includes, for example, a method for detecting a genetic polymorphism of apolipoprotein E present in genomic DNA collected from a subject, comprising the following steps 1 to 3:
1. a step of preparing a specimen with DNA released from saliva;
2. a step of adding the followings to the specimen containing the DNA and then mixing:
(1) a PCR enzyme, (2) a PCR primer pair for amplifying a nucleic acid fragment of the apolipoprotein E gene, and
(3) a fluorescent labeled probe set which has oligonucleotides for detecting the genetic polymorphism of apolipoprotein E; and
3. a step of performing PCR, and measuring the fluorescence intensities according to the genetic polymorphism of apolipoprotein E from the PCR product.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A detection method and a detection device capable of increasing position resolution when detecting a characteristic value distributed in a plane of a sample are provided. The detection method is configured to detect the characteristic value distributed in the plane of the sample by scanning the sample for each analysis area. The detection method includes the steps of: detecting the characteristic value of the sample a plurality of times while moving the analysis area in the plane of the sample so that the partial region of the analysis area overlaps; and calculating the characteristic value distributed in the plane of the sample in a unit of an overlapping region by performing statistical processing on detection results including the same region.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
A high duty cycle ion mobility analysis apparatus includes an ion source, first and second ion storage zones, and an ion mobility analyzer. The ion mobility analyzer includes first and second channels containing a gas flow paralleled to an ion migration direction and a direct current electric field in the opposite direction of the gas flow, and the direct current electric fields in the channels are different in strength. In a continuous scanning period, ions that have not reached appropriate scanning conditions or have missed the appropriate scanning conditions and thus are unable to pass through the mobility analyzer are temporarily stored in two independent ion storage zones without being lost to be analyzed by the mobility analyzer until conditions of the scanning period or a next scanning period are appropriate.
G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
65.
METHOD OF PRODUCING STRESS-LUMINESCENT MATERIAL, METHOD OF PRODUCING STRESS-LUMINESCENT BODY, STRAIN MEASUREMENT METHOD, STRESS-LUMINESCENT BODY, STRESS-LUMINESCENT COATING MATERIAL, AND DEVICE FOR PRODUCING STRESS-LUMINESCENT BODY
A method of producing a stress-luminescent material according to one aspect of the present invention includes a preparation step of preparing a stress-luminescent material including monoclinic particles having a stress luminescence ability, and a pulverization step of pulverizing the stress-luminescent material while maintaining a crystal structure of the monoclinic particles.
G01N 21/70 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light mechanically excited, e.g. triboluminescence
G01N 3/32 - Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
To properly set a predetermined threshold for the number of times of occurrence of an abnormality for issuing an alarm. A vacuum pump system includes a storage, a pump controller, and a setter. The storage stores a first threshold for the number of times of occurrence of the abnormality for outputting the alarm. The pump controller counts the number of times of occurrence of the abnormality caused in a vacuum pump, determines whether or not the number of times of occurrence of the abnormality is the first threshold or more, and outputs the alarm in a case where the number of times of occurrence of the abnormality is the first threshold or more. The setter sets or changes the first threshold on the basis of an operation state of the vacuum pump.
One mode of an optical inspection apparatus according to the present invention is an optical inspection apparatus for optically inspecting an object, the optical inspection apparatus including: a biasing section (20) configured to apply, to a group of objects (23A) on a stage, a force for moving the group of objects away with respect to the stage (22); a catching section (24) including an adhesion portion (241) to which an object in the group of objects moved from the stage adheres; and an analysis section (3) configured to optically analyze the object caught by the catching section. This makes it possible to efficiently and satisfactorily perform optical analysis of individual microplastics by eliminating manual work of picking up the microplastics one by one.
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
An X-ray fluorescence analyzer includes a sample stage having an opening, the sample stage being configured to place a sample thereon so that the sample is exposed from the opening, an X-ray source for irradiating the sample with primary X-rays from below the sample stage through the opening, and a detector for detecting fluorescence X-rays generated from the sample. It further includes an analyzer for analyzing the constituent elements based on the fluorescence X-rays, a measuring device for measuring a height of a surface of the sample exposed from the opening, a determination unit for determining whether a height difference between the height measured by the measuring device and a height of the upper surface of the sample stage is within a tolerance, and a notification unit for notifying a determination result of the determination unit. With this, the reliability of the analysis result can be recognized.
G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
Provided is a sample container and a gas chromatograph capable of detecting the pressure in the flow path for supplying a pressurized gas into a flow path. The ample supply device includes and insertion tube, a pressurized gas supply unit, a valve, and a pressure sensor. The pressurized gas supply unit is connected to the insertion tube via the flow path. The valve opens and closes the flow path. The pressure sensor senses the pressure between the valve and the insertion tube in the flow path. In the sample supply device, the pressure in the flow path connecting the pressurized gas supply unit and the insertion tube is detected, based on the detection signal from the pressure sensor in a state in which the valve is closed, and the insertion tube is inserted into the space in the sample container, before supplying a pressurized gas by a pressurized gas supply unit.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
70.
DATA ANALYSIS METHOD, DATA ANALYSIS SYSTEM, AND DATA ANALYSIS SYSTEM SERVER
A data analysis method includes a storage step of storing a plurality of learning algorithm groups each including a type of measurement data, a type of analysis of the measurement data, and a learning algorithm associated with each other, a learning algorithm selection step of selecting the learning algorithm based on input information, and a trained model generation step of generating a trained model based on training data and the learning algorithm.
An analysis assistance device includes an estimator that estimates a distribution of measurement quality indicator data by performing a regression analysis with use of a plurality of analysis condition data pieces supplied to an analysis device and a plurality of measurement data pieces obtained by the analysis device based on the plurality of analysis condition data pieces, and an analysis assistance information outputter that outputs a distribution of the measurement quality indicator data to a display device. The analysis condition data pieces include a first factor. The estimator estimates respective distributions of the measurement quality indicator data in a case in which the first factor is a first value and a case in which the first factor is a second value. The analysis assistance information outputter outputs the respective distributions to the display device.
A method for analyzing a microorganism including an identification step for determining which of Abony and Pakistan which are two serotypes of Salmonella bacteria is contained in a sample which contains either Abony or Pakistan, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Minnesota, Infantis and Brandenburg which are three serotypes of Salmonella bacteria is contained in a sample which contains Minnesota, Infantis or Brandenburg, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Schwarzengrund and Montevideo which are two serotypes of Salmonella bacteria is contained in a sample which contains either Schwarzengrund or Montevideo, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample.
A member coupling mechanism includes a first member including a cylindrical member coupling portion including a stepped portion inclined along a circumferential direction from a tip end side of the member coupling portion toward a base end side thereof, a second member configured to be coupled to the member coupling portion, and a coupling member configured to be engaged with the stepped portion while holding an end portion of the second member on a first member side. The coupling member is provided with a rotatable cylindrical protrusion protruding toward an outer or inner peripheral surface of the member coupling portion to be engaged with the stepped portion. When the connecting member is rotated in the circumferential direction, the protrusion moves along the stepped portion while rotating to press the first and second members in an approaching direction to couple them.
A mass spectrometry control device includes a deriver that derives, based on a set of allergens that are detectable without being distinguished from one another among a plurality of allergens to be detected and data that indicates a plurality of peptides produced by subjecting each allergen to a cleavage process, first peptides produced in common when the plurality of allergens included in the set are subjected to the cleavage process and at least one of parameters for detecting the first peptides, and a setter that sets a condition of mass spectrometry to detect at least one of the first peptides.
A defect inspection apparatus (100) includes an imager (image sensor 35) configured to image an inspection target 7, and a display (6) configured to display an image based on an image captured by the imager. The defect inspection apparatus (100) also includes a controller (4) configured or programmed to receive a setting of a marking (64) in a predetermined region of interest (S) on the image (still image 61) displayed on the display (6). The controller (4) is configured or programmed to inspect the inspection target (7) for a defect based on the image captured by the imager, and superimpose an image of the marking (64) on a position corresponding to the predetermined region of interest (S) in an image of an inspection result (overlay image 65) displayed on the display (6).
An opening apparatus includes a temperature adjustment section that holds a container body of a PCR container, an opening/closing unit, a moving device, and a control device. The opening and closing unit includes: a rotating member that applies a force to a lid in a direction to open the lid as the rotating member rotates with a projection in contact with the lid in a closed state; and a motor that rotates the rotating member. The moving device moves the temperature adjustment section relative to the rotating member. In conjunction with driving and thus rotating the rotating member, the control device controls the moving device so that the PCR container moves horizontally in a direction from a hinge of the PCR container toward a flange of the PCR container.
A method for analyzing a microorganism including an identification step for determining which of Abony and Pakistan which are two serotypes of Salmonella bacteria is contained in a sample which contains either Abony or Pakistan, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Minnesota, Infantis and Brandenburg which are three serotypes of Salmonella bacteria is contained in a sample which contains Minnesota, Infantis or Brandenburg, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Schwarzengrund and Montevideo which are two serotypes of Salmonella bacteria is contained in a sample which contains either Schwarzengrund or Montevideo, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample.
G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
H01J 49/00 - Particle spectrometers or separator tubes
78.
ANALYSIS DEVICE FOR DATA OBTAINED IN MASS SPECTROMETRY, MASS SPECTROMETRY DEVICE, ANALYSIS METHOD FOR DATA OBTAINED IN MASS SPECTROMETRY AND ANALYSIS PROGRAM
An analysis device for data obtained in mass spectrometry, includes an information acquirer that acquires detection information representing a peptide that is detected when a sample is subjected to a cleavage process and then subjected to mass spectrometry, and an information producer that produces allergen information in regard to an allergen included in the sample based on the detection information and data representing a peptide that is produced when each allergen is subjected to the cleavage process, wherein the information producer produces the allergen information based on a combination of a plurality of peptides in a case in which the plurality of peptides produced from one allergen in the data are detected.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
Provided is an ion analysis device (10) that irradiates sample component-derived precursor ions with radicals so as to generate product ions and analyzes the product ions, said device comprising: a reaction chamber (142) into which the precursor ions are introduced; a radical generation unit (151) which generates radicals; and a radical transport pipe (152) which connects the radical generation unit (151) and the reaction chamber (142), wherein at least part of the inner wall surface of the radical transport pipe (152) is made of a material having a lesser amount of or lower strength of radical adherence to the inner wall surface of the radical transport pipe (152) in comparison with alumina or quartz. One end (1523) of the radical transport pipe (152) is disposed inside the reaction chamber (142) and preferably faces toward a prescribed region (1424) where ions are localized in the reaction chamber (142).
An information processing apparatus capable of communicating with a plurality of chromatograph apparatuses includes a display unit, a display processing unit, and an operation receiving unit. The display processing unit causes the display unit to display a management screen in which a display image for each of the chromatograph apparatuses related to at least one of an analysis result in a plurality of the chromatograph apparatuses and operation on a plurality of the chromatograph apparatuses is arranged at a common aspect ratio. The operation receiving unit receives change operation for changing a display mode of the management screen. When the change operation is received by the operation receiving unit, the display processing unit rearranges the display image in a state where an aspect ratio is maintained.
G09G 5/37 - Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators characterised by the display of individual graphic patterns using a bit-mapped memory - Details of the operation on graphic patterns
A gas chromatograph includes an oven that has a first heater device and a second heater device. The first heater device and the second heater device are connected in series when a voltage of a power supply is a first voltage, and are connected in parallel when the voltage of the power supply is a second voltage that is lower than the first voltage. A power controller includes a first control device that controls ON/OFF of supply of power to the series-connected first heater device and second heater device or ON/OFF of supply of power to the parallel-connected first heater device, and a second control device that controls ON/OFF of supply of power to the parallel-connected second heater device. A controller adjusts a duty ratio of supply of power to the parallel-connected first heater device and second heater device by controlling the first control device and the second control device when the voltage of the power supply is the second voltage.
Provided is a TOFMS having a measurement unit in which target ions are accelerated and sent into a flight space within which an electric field for causing ions to fly is created. A data-analysis processor (33) creates a spectrum based on data acquired by the measurement unit, where the spectrum shows a relationship between ion intensity and time-of-flight or m/z value. An index calculator (34) calculates, as an index concerning a peak in the spectrum, a time-of-flight or m/z-value difference between a midpoint of a first peak width at an intensity which equals the peak-top intensity multiplied by a first ratio and a midpoint of a second peak width at an intensity which equals the peak-top intensity multiplied by a second ratio smaller than the first ratio. An evaluation result storage section (35) evaluates the peak symmetry from the index and stores an evaluation result.
An X-ray phase imaging apparatus includes an X-ray source; an X-ray detector; a plurality of gratings; a subject holder arranged in an X-ray irradiation area and configured to hold the subject; and an image processor configured to generate an X-ray phase contrast image based on an intensity distribution of the X-rays detected by the X-ray detector. The subject holder is formed of a first material having an X-ray transmittance greater than metal and a scattering degree smaller than the metal.
In a TOFMS measurement unit, an ion acceleration section accelerates ions to send them into a flight space, within which a flight-field creation section creates, an electric field for causing ions to fly. A controller unit operates the measurement unit so as to repeat a measurement for a predetermined sample while varying a voltage applied to an electrode in the measurement unit, and calculates mass-resolving power based on each measurement result. An approximate function calculator unit finds an approximate function representing a relationship between the voltage and the mass-resolving power, based on data of combinations of the voltage and the mass-resolving power obtained under the control of the controller unit. A voltage determiner unit determines a voltage value corresponding to a target value of the mass-resolving power by the approximate function, and determines the voltage value as a voltage to be applied to the electrode in the TOFMS concerned.
An orthogonal acceleration time-of-flight mass spectrometer includes: a first vacuum chamber and a second vacuum chamber; an insulating spacer member; a former-stage-side ring electrode; subsequent-stage-side ring electrodes; a first fixation member including a first displacement member to displace a central axis of the former-stage-side ring electrode and the subsequent-stage-side ring electrodes in a predetermined direction orthogonal to the central axis by thermal expansion; and a second fixation member including a second displacement member to displace the central axis in the predetermined direction orthogonal to the central axis by thermal expansion, a difference between a thermal expansion amount of the first displacement member per unit temperature and a thermal expansion amount of the second displacement member per unit temperature being 30% or less of the thermal expansion amount of the first displacement member.
The trigger signal includes a first group of pulses—indicating start timing and a second group of pulses indicating end timing of data processing. The data processing apparatus processes measurement data sets measured during a period between the start timing and the end timing by temporally align the measurement data sets with each other. Each of the first group of pulses and the second group of pulses includes a first pulse and a second pulse different in pulse width from each other. The start timing is timing distant by a first time period from the first pulse or timing distant by a second time period from the second pulse in the first group of pulses, and the end timing is timing distant by the first time period from the first pulse or timing distant by the second time period from the second pulse in the second group of pulses.
G08C 15/12 - Arrangements characterised by the use of multiplexing for the transmission of a plurality of signals over a common path successively, i.e. using time division the signals being represented by pulse characteristics in transmission link
87.
UNDERWATER OPTICAL WIRELESS COMMUNICATION DEVICE AND UNDERWATER OPTICAL WIRELESS COMMUNICATION SYSTEM
An underwater optical wireless communication device (first communication device) is an underwater optical wireless communication device for underwater optical wireless communication. It includes a first light emitter for emitting first light having a first wavelength included in a blue wavelength band as a center wavelength, a first light receiver for receiving second light having a second wavelength included in a green wavelength band as a center wavelength, and a noise suppression unit for suppressing noise caused by green light generated due to the first light.
H04B 10/80 - Optical aspects relating to the use of optical transmission for specific applications, not provided for in groups , e.g. optical power feeding or optical transmission through water
88.
Display screen or portion thereof of an electrophoresis device with graphical user interface
A position estimator outputs, by inputting information obtained from the frame images into a trained model, positional information of a plurality of parts of a human body from the trained model. A determination processor outputs information on erroneous detection by the position estimator. The position estimator outputs a first position group in response to an input of an obtained first frame image, the first frame image being obtained by the receiver and outputs a second position group in response to an input of an obtained second frame image different from the first frame image, the second frame image being obtained by the receiver. The determination processor outputs the information on erroneous detection by the position estimator based on a degree of difference between the first position group and the second position group and a degree of matching between the first frame image and the second frame image.
A gas chromatograph includes a sample introduction unit configured to introduce a vaporized sample into a separation column together with a carrier gas, a detection unit configured to detect a gas emitted from the separation column, and a catalyst processing unit. The catalyst processing unit includes a catalyst configured to introduce a gas containing the carrier gas discharged from the sample introduction unit or the detection unit to oxidize the hydrogen gas.
In an X-ray CT apparatus, a processor is configured to display, on a display device, a tomographic image, and perform processing of displaying a GUI, which is a graphical user interface for setting or adjusting a Hilbert transformation region on which processing by the Hilbert transformation is performed, in region-of-interest reconstruction processing.
In an X-ray CT apparatus, a processor is configured to display, on a display device, an X-ray projection image based on projection data, and perform processing of displaying a GUI, which is a graphical user interface for setting or adjusting a region of interest in a rotation axis direction of a subject for which a tomographic image is reconstructed, in region-of-interest reconstruction processing.
An analysis data processing device includes an information producer that produces first information in regard to whether a first substance to be analyzed is included in a sample based on first data in which a first substance and a plurality of second substances included in the first substance or produced by decomposition or reaction of the first substance are associated with each other and second data obtained by detection of a second substance in an analysis of the sample, and an output controller that outputs the first information together with information of the detected substance.
A seal portion 24 is arranged between a first fixing surface 222 and a second fixing surface 311. A biasing member 25 comes into contact with a tapered surface 332 of a male terminal 331 received in a female terminal 231 and applies a force in a direction in which the male terminal 331 and the female terminal 231 are moved closer to each other. In a state where the male terminal 331 is received in the female terminal 231, the seal portion 24 is compressed by being sandwiched between the first fixing surface 222 and the second fixing surface 311, and a periphery of the male terminal 331 and the female terminal 231 becomes in a state of being sealed by the seal portion 24.
A monitoring system includes: an analysis device; a controller that controls the analysis device; and a monitoring device. The monitoring device is capable of communicating with the controller and monitors an operation status of the analysis device. The monitoring device obtains, from the controller, monitoring data including an analysis state and analysis data of the analysis device. In response to a request command from a request origin, the monitoring device generates display data using the monitoring data, and transmits the generated display data to a terminal device of the request origin. The request command includes identification information of the request origin. The monitoring device changes the display data in accordance with the identification information.
Identification information for identifying each analysis appliance and consumable information representing a usage state of a consumable included in each analysis appliance are acquired by an information acquirer from a control device. The identification information and the consumable information acquired by the information acquirer are held by an information holder. A display controller causes a display device to display a list screen of identification information held by the information holder. Further, the display controller causes a usage state of a consumable for each analysis appliance to be displayed on the list screen based on consumable information held by the information holder.
A radical generation device includes: a cylindrical tube; an antenna; an outer conductor part; and a connection part which has a double cylindrical tube structure including an inner cylindrical body and an outer cylindrical body, end portions of the inner cylindrical body and the outer cylindrical body on the same side are divided in a circumferential direction notches extending in an axial direction to form divided pieces, and tapered portions swelling outward toward a tip end are formed on an outer side of the divided pieces or tapered portions swelling inward toward a tip end are formed on an inner side of the divided pieces.
An inspection apparatus includes a measurement unit, a flow-in tube for flow of sample water into the measurement unit, a connection portion that connects a sample tube and the measurement unit to each other, a liquid sending portion that sends sample water to the measurement unit, a pressurization pump that increases a pressure in the inside of the sample tube, and a controller. The controller controls operations of the liquid sending portion and the pressurization pump to suppress within a prescribed range, variation in pressure applied to sample water until sample water reaches the measurement unit from the inside of the sample tube.
G01N 1/14 - Suction devices, e.g. pumps; Ejector devices
G01N 27/06 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
100.
DATA ANALYSIS APPARATUS, DATA ANALYSIS METHOD, METHOD OF GENERATING TRAINED MODEL, SYSTEM, AND PROGRAM
A data analysis apparatus, a data analysis method, a method of generating a trained model, a system, and a program that allow highly accurate and easy analysis of an FT-IR spectrum are provided. The data analysis apparatus includes an obtaining unit that obtains an analysis target which is an FT-IR spectrum, a trained model, and an analyzer that inputs the analysis target to the trained model. The trained model is machine-trained so as to output, when the trained model receives input of an FT-IR spectrum, information indicating whether or not the inputted FT-IR spectrum includes a peak derived from a trained atomic group. The trained atomic group includes an atomic group containing at least three atoms.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
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