Abstract

The present invention relates to a composite for a thermal block of a thermal cycler. The composite has both low specific heat characteristics and remarkably improved thermal conductivity, and thus, when the temperature of a thermal block, which is manufactured using the composite, rises and falls, deviation in temperature change rate between a plurality of unit thermal blocks and/or in different areas in a unit thermal block can be remarkably reduced such that a PCR thermal cycler including the thermal block can ensure reliability even in ultrafast PCR.

IPC Classes  ?

• C09K 5/14 - Solid materials, e.g. powdery or granular
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• C22C 13/00 - Alloys based on tin
• B22F 1/054 - Nanosized particles

Abstract

The present invention relates to a double-helix oligonucleotide construct comprising a double-stranded miRNA and a composition for preventing or treating cancer comprising the same. More particularly, the present invention relates to a double-helix oligonucleotide construct comprising miR-544a characterized by a method that effectively inhibits the proliferation of cancer cells or induces a voluntary death of cancer cells, and an anticancer composition comprising the construct.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system and, more specifically, to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system, in which dispensing of a liquid sample and extraction, amplification and testing of nucleic acids are integrally carried out. The sample tube opening/closing device includes: a housing that forms an inner space isolated from the outside and includes a door for carrying in/out a multi-well plate for biological samples, including a plurality of sample tubes in which biological samples are accommodated; and a sample tube opening/closing part that is installed in the inner space to be spaced apart from the multi-well plate for biological samples and automatically opens and closes the sample tubes.

IPC Classes  ?

• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01L 3/02 - Burettes; Pipettes

Abstract

The present invention relates to a method for isolating a nucleic acid by using: a binding buffer containing acetic acid or phosphoric acid; and the pH difference between binding and washing buffers, and an elution buffer, wherein silica magnetic particles are added to a biological sample including a nucleic acid to which a binding buffer containing acetic acid, phosphoric acid, etc., has been added, thereby binding the nucleic acid to the magnetic particles, after which a magnetic field is applied to separate the magnetic particles, and the nucleic acid is purified in a basic pH elution buffer. The method uses the pH difference, and can isolate the nucleic acid more quickly and efficiently than centrifugation or gravity separation. In addition, since ethanol is not used, high-purity nucleic acid can be isolated and purified to obtain more accurate results in subsequent experiments.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C07H 1/06 - Separation; Purification
• B03C 1/01 - Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
• B03C 1/28 - Magnetic plugs and dipsticks

Abstract

The present invention relates to a nucleic acid amplification test apparatus, and an automatic sample analysis system having same and, more particularly, to a nucleic acid amplification test apparatus in which separation and purification, dispensation, amplification, and testing of samples are performed integrally, and an automatic sample analysis system having same. Disclosed in the present invention is a nucleic acid amplification test apparatus comprising: a housing (30) having an inner space (S1) isolated from the outside; a multi-well plate insertion unit (100) into which a multi-well plate (40) having a plurality of reaction tubes (1) accommodating a target nucleic acid solution is inserted through an automatic purification and dispensing apparatus (10); a sealing plate insertion unit (200) into which a sealing plate (50) having a sealing means for sealing the inlets of the plurality of reaction tubes (1); a fluorescence detection unit (400) disposed on an upper side of the sealing plate insertion unit (200) and detecting a target nucleic acid in the reaction tubes (1); and a temperature control block (500) disposed on a lower side of the multi-well plate insertion unit (100) and controlling the temperature of the reaction tubes (1), wherein the reaction tubes (1) are moved relatively so as to be adjacent to the sealing means to be then sealed by the sealing means.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• B01L 3/02 - Burettes; Pipettes
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

The present invention relates to a double-stranded oligonucleotide capable of inhibiting amphiregulin expression in a very specific and highly efficient manner, preferably a double-stranded oligonucleotide comprising a sequence in the form of an RNA/RNA, DNA/DNA or DNA/RNA hybrid, and the use of a double-stranded oligonucleotide structure, which comprises the double-stranded oligonucleotide, and nanoparticles, for preventing or treating obesity.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 3/04 - Anorexiants; Antiobesity agents

Abstract

The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

Abstract

The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

Goods & Services

Functional cosmetics; cosmetics for scalp; hair strengthening treatment lotions; hair stabilizers, namely, hair care preparations for strengthening and smoothing hair; hair care agents being hair care preparations; hair lotions; hair care preparations; hair conditioner; hair care lotions; hair care creams; cosmetic preparations for hair care; hair essences, namely, hair oils; hair essence mists being hair care preparations; beauty creams; cosmetic preparations for skin care; face and body lotions; make-up preparations for the face and body; face and body beauty creams; lotions for face and body care; cosmetic creams and lotions; face and body creams; shampoo; beauty masks; hair colorants; colouring preparations for cosmetic purposes; skin whitening preparations; hair cleaning preparations; cosmetic preparations for the hair and scalp; depilatory creams; depilatory preparations; depilatories; non-medicated scalp stimulating preparations, not for medical use; non-medicated toners for scalp, not for medical use Medicated hair care preparations; medicinal preparations for stimulating hair growth; hair growth stimulants; medicated hair lotions; medicated scalp treatments, namely, medicated scalp cream

Abstract

The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit the proliferation of Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide; and a use thereof for treating COVID-19.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/51 - Nanocapsules
• A61P 31/14 - Antivirals for RNA viruses
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

Abstract

Aphanomyces invadansAphanomyces invadans and/or internal transcribed spacer 1 (ITS1) thereof, a composition for detecting epizootic ulcerative syndrome comprising same, a detection kit therefor, and a method for detecting epizootic ulcerative syndrome using same.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa

Abstract

The present invention relates to a composition for detecting a white spot syndrome virus and a method for detecting same and, particularly, to a pair of primers for amplifying VP664 and/or VP28, which are genes expressing envelope proteins of a white spot syndrome virus, a composition for detecting a white spot syndrome virus comprising same, a kit for detection, and a method for detecting a white spot syndrome virus using same.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Goods & Services

Functional cosmetics; cosmetics for scalp; hair strengthening treatment lotions; hair stabilizers; hair care agents; hair lotions; hair care preparations; hair conditioner; hair care lotions; hair care creams; cosmetic preparations for hair care; hair essences; hair essence mists; beauty creams; cosmetic preparations for skin care; face and body lotions; make-up preparations for the face and body; face and body beauty creams; lotions for face and body care; cosmetic creams and lotions; face and body creams; shampoo; beauty masks; hair colorants; colouring preparations for cosmetic purposes; skin whitening preparations; hair cleaning preparations; cosmetic preparations for the hair and scalp; depilatory creams; depilatory preparations; depilatories; scalp stimulating preparations (not for medical use); toners for scalp (not for medical use). Medicated hair care preparations; medicinal preparations for stimulating hair growth; hair growth stimulants; medicated hair lotions; scalp treatments (Medicated -).

Goods & Services

Cartridges for storing specimen used for DNA analysis apparatus; reagent cartridges used for DNA analysis apparatus; reagent containers used for DNA analysis apparatus; DNA analysis apparatus, not for medical purposes; diagnostic equipments for molecular diagnosis [non-medical]; genetic analyzer, not for medical purposes; gene amplification equipment, not for medical purposes; diagnostic apparatus, not for medical purposes; integrated genetic testing apparatus, not for medical purposes; nucleic acid amplification apparatus for laboratory use; gene analyzing and extracting devices, not for medical purposes; physical analysing apparatus for analysing genes [other than for medical use]; chemical analysing apparatus for analysing genes [other than for medical use]; plate for analyzing genes; genetic probe assay apparatus, not for medical purposes; gene amplifiers; devices for analyzing gene information, not for medical purposes. Medical apparatus and instruments for DNA/RNA analysis; bacteria and virus testing apparatus, for medical and veterinary use; miniaturized sensors for use in gene analysis and diagnosis, for medical and veterinary use; DNA/RNA purification apparatus for medical and veterinary use; genetic testing apparatus for medical and veterinary purposes; medical genetic analyzer for medical and veterinary use; gene amplification apparatus for medical and veterinary use; apparatus for DNA and RNA testing for medical purposes; DNA extraction and purification apparatus for medical purposes; real-time gene amplification equipment for medical use; medical genetic fragment analyzers; diagnostic apparatus for medical use; apparatus for carrying out diagnostic tests for medical purposes; medical diagnostic apparatus and instruments; diagnostic apparatus for medical purposes; automatic molecular diagnosis device of diagnostic and medical use; in vitro diagnostic devices for medical purposes; genetic testing apparatus for in vitro diagnostic use, for medical and veterinary use.

Abstract

The present disclosure relates to a trackable precise-sample-injection device for a multi-well plate and, more specifically, to a trackable precise-sample-injection device for a multi-well plate, the device being capable of: preventing cross-contamination that can occur when many samples are manually put into a multi-well plate, and a diagnosis error caused by the injection of a sample into the wrong well or repeated injection; and simply recording and tracking information about wells into which samples are injected. The present disclosure relates to a trackable precise-sample-injection device for a multi-well plate, the device being capable of being efficiently used for a pooling inspection, and the like by injecting a plurality of samples into a multi-well plate.

IPC Classes  ?

• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The present invention relates to a composition using a urine sample for diagnosis of a kidney disease and, more specifically, to a urine test composition and a kit for diagnosis of a kidney disease, each comprising an agent specifically detecting amphiregulin from a urine sample, and a method for diagnosing a kidney disease by using the composition. According to the present invention, not only is there an advantage of being able to conveniently diagnose a kidney disease in a non-invasive manner using a urine sample for a kidney disease to which early diagnosis is important, but also the application of the present invention to a patient diagnosed with chronic kidney disease can advantageously predict the plausibility of progression into end-stage renal disease in advance.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Goods & Services

(1) Beauty creams; beauty masks; cosmetic creams and lotions; cosmetic preparations for hair care; cosmetic preparations for skin care; cosmetic preparations for the hair and scalp; depilatories; depilatory creams; depilatory preparations; face and body beauty creams; face and body creams; face and body lotions; hair care creams; hair care lotions; hair care preparations; hair cleaning preparations; hair colorants; hair conditioner; hair lotions; hair strengthening treatment lotions; lotions for face and body care; make-up preparations for the face and body; shampoos; skin whitening preparations (2) Hair growth stimulants; medicinal preparations for stimulating hair growth

Goods & Services

Functional cosmetics; cosmetics for scalp; hair strengthening treatment lotions; hair stabilizers, namely, hair care preparations for strengthening and smoothing hair; hair care agents being hair care preparations; hair lotions; hair care preparations; hair conditioner; hair care lotions; hair care creams; cosmetic preparations for hair care; hair essences being hair care preparations; hair essence mists being hair care preparations; beauty creams; cosmetic preparations for skin care; face and body lotions; make-up preparations for the face and body; face and body beauty creams; lotions for face and body care; cosmetic creams and lotions; face and body creams; shampoo; beauty masks; hair colorants; colouring preparations for cosmetic purposes; skin whitening preparations; hair cleaning preparations; cosmetic preparations for the hair and scalp; depilatory creams; depilatory preparations; depilatories; non-medicated scalp stimulating preparations, not for medical use; non-medicated toners for scalp, not for medical use Medicated hair care preparations; medicinal preparations for stimulating hair growth; hair growth stimulants; medicated hair lotions; medicated scalp treatments

Abstract

The present invention relates to a double-stranded oligonucleotide capable of inhibiting CTGF expression with a very specific and high efficiency, a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, and a use thereof in preventing or treating of fibrotic or respiratory diseases.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

15/223/2211 ≤ 0.2

IPC Classes  ?

• H01B 1/02 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of metals or alloys
• H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

An electromagnetic shielding composition according to the present invention is directed to an electromagnetic shielding composition capable of forming an electromagnetic shielding film with excellent electromagnetic shielding capacity and flexibility and, specifically, comprises: a core-shell structured metal nanowire comprising a core containing copper and a shell containing silver on the core; and plate-like metal particles selected from plate-like silver particles and silver-coated plate-like copper particles.

IPC Classes  ?

• H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

Abstract

A conductive paste composition according to the present disclosure contains silver-coated copper nanowires with a core-shell structure; a binder mixture containing a silicone resin binder and a hydrocarbon-based resin binder; and an organic solvent, such that the conductive paste composition has a low sheet resistance and may withstand a high temperature, thereby implementing excellent conductivity and electromagnetic wave shielding properties. Furthermore, the conductive paste may be widely used in various fields such as electromagnetic wave shielding, solar cell electrodes, electronic circuits.

IPC Classes  ?

• C08K 3/08 - Metals
• C08J 7/044 - Forming conductive coatings; Forming coatings having anti-static properties
• C08J 5/18 - Manufacture of films or sheets
• H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys
• B82Y 40/00 - Manufacture or treatment of nanostructures
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C08K 9/02 - Ingredients treated with inorganic substances
• C08K 7/06 - Elements

Abstract

Provided is an electric grill capable of precisely controlling the temperature of a grilling plate by directly applying a heating paste including carbon nanotubes to the bottom of the grilling plate. The present invention includes the grilling plate on which food to be cooked is placed; a heating body that is applied so as to be arranged on the lower portion of the grilling plate so as to heat the grilling plate; a heat insulating material which is disposed to be spaced apart from the heating body at a predetermined distance so as to block heat conduction to the outside; and a temperature sensor which is disposed between the heating body and the heat insulating material so as to measure the temperature of an upper plate. A pair of electrodes for supplying electricity to the heating body are arranged along opposite edges of both sides of the heating body, and a heating region can be divided and controlled by dividing and combining the pair of electrodes, the heating body, the coating thickness, and the like.

IPC Classes  ?

• A47J 37/06 - Roasters; Grills; Sandwich grills
• H05B 3/26 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible heating conductor mounted on insulating base
• H05B 3/03 - Electrodes
• H05B 1/02 - Automatic switching arrangements specially adapted to heating apparatus
• F24C 7/08 - Arrangement or mounting of control or safety devices
• A47J 36/04 - Selection of specific materials, e.g. heavy bottoms with copper inlay or with insulating inlay the materials being non-metallic

Goods & Services

Silicone based sealants and adhesives

Abstract

The present invention relates to a composition for administering a double-stranded oligonucleotide structure using an ultrasonic nebulizer. According to the method, the double-stranded oligonucleotide according to the present invention forms self-assembled nanoparticles, which are 90 nm in size and have a neutral charge, and it is possible to deliver the double-stranded oligonucleotide specifically to the nasal cavity and lungs while maintaining not only the same concentration, molecular weight, purity, nanoparticle size, and osmolality as those of the stock material but also the target gene inhibitory activity without cytotoxicity. Thus, the present invention may be useful for the prevention or treatment of respiratory viral infections including COVID-19, pulmonary fibrosis caused by viral infection, or respiratory diseases.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The present invention relates to a composition for administering a double-stranded oligonucleotide structure using an ultrasonic nebulizer. The method allows the double-stranded oligonucleotide, according to the present invention, which forms self-assembled nanoparticles having a neutral charge of 90 nm in an aqueous solution, to maintain the same concentration, molecular weight, purity, nanoparticle size, and osmolality as the undiluted solution material. In addition, the method can maintain target gene suppression ability without cytotoxicity and can deliver drugs specifically to the nasal cavity and lungs, thus allowing the present invention to be utilized in the prevention or treatment of respiratory viral infections including COVID-19, pulmonary fibrosis caused by viral infections, or respiratory diseases.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

The present invention relates to a composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded miRNA as an active ingredient and, more specifically, to: miR-3139, miR-3189, miR-3199 or miR-8485, which are double-stranded miRNA; a double-stranded oligonucleotide structure comprising same; or a pharmaceutical or cosmetic composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising nanoparticles containing the structure as an active ingredient. A composition according to the present invention can prevent hair graying and reduce the rate of progress thereof by activating melanocytes and promoting melanogenesis and can allow the hair already affected by graying to be improved to a state before graying. In addition, the composition promotes the activation of melanocytes and the proliferation of dermal papilla cells and keratinocytes that are present in hair follicles, and induces outer root sheath development and hair growth so that the effects of promoting hair growth and/or preventing hair loss can be exhibited.

IPC Classes  ?

• A61K 8/60 - Sugars; Derivatives thereof
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 9/51 - Nanocapsules
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

The present invention relates to a composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded miRNA as an active ingredient and, more specifically, to: miR-3139, miR-3189, miR-3199 or miR-8485, which are double-stranded miRNA; a double-stranded oligonucleotide structure comprising same; or a pharmaceutical or cosmetic composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising nanoparticles containing the structure as an active ingredient. A composition according to the present invention can prevent hair graying and reduce the rate of progress thereof by activating melanocytes and promoting melanogenesis and can allow the hair already affected by graying to be improved to a state before graying. In addition, the composition promotes the activation of melanocytes and the proliferation of dermal papilla cells and keratinocytes that are present in hair follicles, and induces outer root sheath development and hair growth so that the effects of promoting hair growth and/or preventing hair loss can be exhibited.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 9/51 - Nanocapsules
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• A61K 8/60 - Sugars; Derivatives thereof

Goods & Services

functional cosmetics; cosmetics for scalp; hair strengthening treatment lotions; hair stabilizers; hair care agents; hair lotions; hair care preparations; hair conditioner; hair care lotions; hair care creams; cosmetic preparations for hair care; hair essences; hair essence mists; beauty creams; cosmetic preparations for skin care; face and body lotions; make-up preparations for the face and body; face and body beauty creams; lotions for face and body care; cosmetic creams and lotions; face and body creams; shampoo; beauty masks; hair colorants; colouring preparations for cosmetic purposes; skin whitening preparations; hair cleaning preparations; cosmetic preparations for the hair and scalp; depilatory creams; depilatory preparations; depilatories; scalp stimulating preparations (not for medical use); toners for scalp (not for medical use). medicated hair care preparations; medicinal preparations for stimulating hair growth; hair growth stimulants; medicated hair lotions; scalp treatments (Medicated -).

Abstract

The present invention relates to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system and, more specifically, to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system, in which dispensing of a liquid sample and extraction, amplification and testing of nucleic acids are integrally carried out. In the present invention, disclosed is a sample tube opening/closing device comprising: a housing (110) that forms an inner space isolated from the outside and includes a door (120) for moving in/out a multi-well plate (20) for biological samples, including a plurality of sample tubes (10) in which biological samples are accommodated; and a sample tube opening/closing part that is installed in the inner space to be spaced apart from the multi-well plate (20) for biological samples and automatically opens and closes the sample tubes (10).

IPC Classes  ?

• B01L 3/02 - Burettes; Pipettes

Abstract

The present invention relates to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system and, more specifically, to an adapter for mounting a conductive pipette, a sample tube opening/closing device, and an automatic sample analysis system, in which dispensing of a liquid sample and extraction, amplification and testing of nucleic acids are integrally carried out.In the present invention, disclosed is a sample tube opening/closing device comprising: a housing (110) that forms an inner space isolated from the outside and includes a door (120) for carrying in/out a multi-well plate (20) for biological samples, including a plurality of sample tubes (10) in which biological samples are accommodated; and a sample tube opening/closing part that is installed in the inner space to be spaced apart from the multi-well plate (20) for biological samples and automatically opens and closes the sample tubes (10).

IPC Classes  ?

• B01L 3/02 - Burettes; Pipettes

Abstract

The present invention relates to a system structure capable of performing real-time detection of nucleic acid extraction and amplification reactions and amplified results in a device for implementing a polymerase chain reaction (PCR). A PCR system includes a nucleic acid extraction cartridge configured to extract a nucleic acid of a biological sample via a nucleic acid extraction reagent stored therein and form a PCR preliminary mixture by being additionally mixed with a polymerase reaction dried product, a PCR plate inserted into the nucleic acid extraction cartridge, having a channel coupled to the nucleic acid extraction cartridge, and receives a nucleic acid solution or the PCR preliminary mixture extracted from the nucleic acid extraction cartridge and diversely accommodates a PCR reaction dried product containing a dried primer/probe or a primer/probe in at least one reaction well, a temperature control module disposed above the PCR plate 200 and including a pair of heating blocks 310 and 320 adjacent to the reaction well (W) to apply different temperatures, and a scanning module scanning a concentration of a reactant amplified in the reaction well (W).

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present invention relates to a method for isolating a nucleic acid by using: a binding buffer containing acetic acid or phosphoric acid; and the pH difference between binding and washing buffers, and an elution buffer, wherein silica magnetic particles are added to a biological sample including a nucleic acid to which a binding buffer containing acetic acid, phosphoric acid, etc., has been added, thereby binding the nucleic acid to the magnetic particles, after which a magnetic field is applied to separate the magnetic particles, and the nucleic acid is purified in a basic pH elution buffer. The method uses the pH difference, and can isolate the nucleic acid more quickly and efficiently than centrifugation or gravity separation. In addition, since ethanol is not used, high-purity nucleic acid can be isolated and purified to obtain more accurate results in subsequent experiments.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

Disclosed are a double stranded oligonucleotide construct, configured such that a hydrophilic material and a hydrophobic material are conjugated through a simple covalent bond or a linker-mediated covalent bond to both ends of a double stranded oligonucleotide in order to efficiently deliver an androgen-receptor-specific oligonucleotide into a cell, a nanoparticle capable of being produced by self-assembling double stranded oligonucleotide constructs in an aqueous solution through hydrophobic interactions, and a composition for preventing hair loss or promoting hair growth containing the double stranded oligonucleotide construct. The double stranded oligonucleotide construct including the androgen-receptor-specific oligonucleotide and the composition for preventing hair loss or promoting hair growth containing the same as an active ingredient can suppress the expression of an androgen receptor with high efficiency without side effects, and can thus exhibit excellent effects on preventing hair loss, particularly androgenetic alopecia, alopecia areata, and telogen effluvium, and promoting hair growth.

IPC Classes  ?

• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61Q 7/00 - Preparations for affecting hair growth
• A61K 8/60 - Sugars; Derivatives thereof
• A61K 8/86 - Polyethers
• A61K 8/88 - Polyamides
• A61K 8/84 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

The present invention relates to a nucleic acid amplification test apparatus, and an automatic sample analysis system having same and, more particularly, to a nucleic acid amplification test apparatus in which separation and purification, dispensation, amplification, and testing of samples are performed integrally, and an automatic sample analysis system having same. Disclosed in the present invention is a nucleic acid amplification test apparatus comprising: a housing (30) having an inner space (S1) isolated from the outside; a multi-well plate insertion unit (100) into which a multi-well plate (40) having a plurality of reaction tubes (1) accommodating a target nucleic acid solution is inserted through an automatic purification and dispensing apparatus (10); a sealing plate insertion unit (200) into which a sealing plate (50) having a sealing means for sealing the inlets of the plurality of reaction tubes (1); a fluorescence detection unit (400) disposed on an upper side of the sealing plate insertion unit (200) and detecting a target nucleic acid in the reaction tubes (1); and a temperature control block (500) disposed on a lower side of the multi-well plate insertion unit (100) and controlling the temperature of the reaction tubes (1), wherein the reaction tubes (1) are moved relatively so as to be adjacent to the sealing means to be then sealed by the sealing means.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• C12Q 1/686 - Polymerase chain reaction [PCR]
• B01L 3/02 - Burettes; Pipettes
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The present invention relates to a nucleic acid amplification test apparatus, and an automatic sample analysis system having same and, more particularly, to a nucleic acid amplification test apparatus in which separation and purification, dispensation, amplification, and testing of samples are performed integrally, and an automatic sample analysis system having same. Disclosed in the present invention is a nucleic acid amplification test apparatus comprising: a housing (30) having an inner space (S1) isolated from the outside; a multi-well plate insertion unit (100) into which a multi-well plate (40) having a plurality of reaction tubes (1) accommodating a target nucleic acid solution is inserted through an automatic purification and dispensing apparatus (10); a sealing plate insertion unit (200) into which a sealing plate (50) having a sealing means for sealing the inlets of the plurality of reaction tubes (1); a fluorescence detection unit (400) disposed on an upper side of the sealing plate insertion unit (200) and detecting a target nucleic acid in the reaction tubes (1); and a temperature control block (500) disposed on a lower side of the multi-well plate insertion unit (100) and controlling the temperature of the reaction tubes (1), wherein the reaction tubes (1) are moved relatively so as to be adjacent to the sealing means to be then sealed by the sealing means.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• B01L 3/02 - Burettes; Pipettes
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle capable of being produced through self-assembly of the double-stranded oligonucleotide construct through a hydrophobic interaction in an aqueous solution; and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide, a nanoparticle, and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention very efficiently suppress the expression of DKK1 without side effects and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth.

IPC Classes  ?

• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size.

IPC Classes  ?

• G01N 30/30 - Control of physical parameters of the fluid carrier of temperature
• G01N 30/60 - Construction of the column
• H05B 3/14 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material the material being non-metallic
• G01N 30/02 - Column chromatography

Abstract

A sample concentrator tube having a heat-resistant planar heating element adhered thereto, an analysis device comprising the same, and an analysis method using the same, according to the present invention, have an effect capable of precisely controlling the temperature by uniformly and rapidly heating the sample concentrator tube to a target temperature for desorption, and capable of almost simultaneously desorbing an adsorbed sample in any part of an adsorbent by minimizing a local temperature difference of the adsorbent in the tube. In addition, it is possible to minimize chemical noise by preventing thermal denaturation of the adsorbent caused by over-heating, and there is an advantage of excellent reproducibility as well as an effect of being inexpensive, economical, and excellent in energy efficiency.

IPC Classes  ?

• G01N 1/40 - Concentrating samples
• G01N 1/44 - Sample treatment involving radiation, e.g. heat
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• H05B 3/26 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible heating conductor mounted on insulating base
• H05B 3/46 - Heating elements having the shape of rods or tubes non-flexible heating conductor mounted on insulating base
• H05B 3/06 - Heater elements structurally combined with coupling elements or with holders
• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

The present invention relates to a probe having octamine or octamine derivative bound thereto in addition to a reporter and a quencher to thus allow the quencher to more effectively suppress light emitted by the reporter, and to uses of the probe. When the probe according to the present invention is utilized, octamine or octamine derivative bound to the probe effectively suppresses the light emitted by the quencher for the reporter, and results in effects such as i) a reduction in base fluorescence, ii) an increase in delta fluorescence, and iii) a decrease in the value of cycle at threshold, thus allowing the probe to be effectively used in a variety of real-time polymerase chain reactions requiring accuracy and sensitivity.

IPC Classes  ?

• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit the proliferation of Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide; and a use thereof for treating COVID-19.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 31/14 - Antivirals for RNA viruses
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit the proliferation of Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide; and a use thereof for treating COVID-19.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit amphiregulin expression, preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; and a use, of a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, for preventing or treating obesity.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61P 3/04 - Anorexiants; Antiobesity agents

Abstract

The present invention relates to a double-stranded oligonucleotide capable of inhibiting amphiregulin expression in a very specific and highly efficient manner, preferably a double-stranded oligonucleotide comprising a sequence in the form of an RNA/RNA, DNA/DNA or DNA/RNA hybrid, and the use of a double-stranded oligonucleotide structure, which comprises the double-stranded oligonucleotide, and nanoparticles, for preventing or treating obesity.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61P 3/04 - Anorexiants; Antiobesity agents

Abstract

The present invention relates to a trackable precise-sample-injection device for a multi-well plate and, more specifically, to a trackable precise-sample-injection device for a multi-well plate, the device being capable of: preventing cross-contamination that can occur when many samples are manually put into a multi-well plate, and a diagnosis error caused by the injection of a sample into the wrong well or repeated injection; and simply recording and tracking information about wells into which samples are injected. The present invention relates to a trackable precise-sample-injection device for a multi-well plate, the device being capable of being efficiently used for a pooling inspection, and the like by injecting a plurality of samples into a multi-well plate.

IPC Classes  ?

• B01L 3/02 - Burettes; Pipettes
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

The present invention relates to a composition using a urine sample for diagnosis of a kidney disease and, more specifically, to a urine test composition and a kit for diagnosis of a kidney disease, each comprising an agent specifically detecting amphiregulin from a urine sample, and a method for diagnosing a kidney disease by using the composition. According to the present invention, not only is there an advantage of being able to conveniently diagnose a kidney disease in a non-invasive manner using a urine sample for a kidney disease to which early diagnosis is important, but also the application of the present invention to a patient diagnosed with chronic renal failure can advantageously predict the plausibility of progression into end-stage renal failure in advance.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

The present invention relates to an extraction apparatus capable of simultaneously extracting target materials from multiple biological samples and, more particularly, to a target material extraction apparatus in which magnetic bar blocks can be replaced according to kinds of multi-well plates to be inserted into a cartridge. When used, the target material extraction apparatus of the present invention is operated in such a manner that among various multi-well plates having different numbers of wells, multi-well plates suitable for a use purpose are loaded into a cartridge within the apparatus and magnetic bar blocks equipped with magnetic bars suitable therefor are selected and loaded. Thus, the apparatus has the advantage of selectively applying various multi-well plates to one installment according to the number of samples from which a target material is extracted or to the amount of the target material to be extracted.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The present invention relates to a lactic acid bacterium isolated from human mother's milk, more precisely a Lactobacillus gasseri BNR17 strain that is isolated from Korean mother's milk and has excellent probiotic activity including acid resistance, bile acid resistance and antimicrobial activity and weight gaining inhibitory effect as well. Again, the Lactobacillus gasseri BNR17 of the present invention has excellent acid resistance, bile acid resistance, enteric absorption activity and antimicrobial activity against pathogenic microorganisms, in addition to the weight gaining inhibitory effect by synthesizing indigestible polysaccharides from monosaccharides included in food taken and releasing the synthesized polysaccharides out of the body. Therefore, the strain of the invention, owing to such beneficiary effects, can be effectively used not only for the production of fermented milk, other fermented food products and animal feeds but also for the production of live cell products and food additives for preventing weight gaining.

IPC Classes  ?

• C12R 1/225 - Lactobacillus
• A23L 33/18 - Peptides; Protein hydrolysates
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23C 9/123 - Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
• C07K 14/335 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
• C12N 1/20 - Bacteria; Culture media therefor
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

An electric roasting pan according to the present invention comprises: a roasting pan; a heating layer being in surface contact with the roasting pan and comprising a carbon nanotube and a silicone-based adhesive; and an electrode in contact with the heating layer. The electric roasting pan has excellent thermal efficiency thanks to the minimal heat loss thereof, can reach a target temperature within a short time to reduce a preheating time, and affords excellent cooking quality. Furthermore, the electric roasting pan can substantially prevent the occurrence of temperature deviation across the area of the roasting pan during a temperature increase and is of high durability and safety.

IPC Classes  ?

• H05B 3/14 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material the material being non-metallic
• H05B 1/02 - Automatic switching arrangements specially adapted to heating apparatus
• A47J 36/04 - Selection of specific materials, e.g. heavy bottoms with copper inlay or with insulating inlay the materials being non-metallic
• A47J 37/10 - Frying pans, e.g. frying pans with integrated lids or basting devices
• C09D 101/28 - Alkyl ethers

Abstract

The present invention relates to a double-stranded oligonucleotide capable of inhibiting CTGF expression with a very specific and high efficiency, a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, and a use thereof in preventing or treating of fibrotic or respiratory diseases.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The present invention relates to a double-stranded oligonucleotide capable of inhibiting CTGF expression with a very specific and high efficiency, a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, and a use thereof in preventing or treating of fibrotic or respiratory diseases.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to an electric grill capable of precisely controlling the temperature of a grilling plate by directly applying a heating paste including carbon nanotubes to the bottom of the grilling plate. The present invention comprises: the grilling plate on which food to be cooked is placed; a heating body that is applied so as to be arranged on the lower portion of the grilling plate so as to heat the grilling plate; a heat insulating material which is disposed to be spaced apart from the heating body at a predetermined distance so as to block heat conduction to the outside; and a temperature sensor which is disposed between the heating body and the heat insulating material so as to measure the temperature of an upper plate, wherein a pair of electrodes for supplying electricity to the heating body are arranged along opposite edges of both sides of the heating body, and a heating region can be divided and controlled by dividing and combining the pair of electrodes, the heating body, the coating thickness, and the like.

IPC Classes  ?

• A47J 37/06 - Roasters; Grills; Sandwich grills
• H05B 1/02 - Automatic switching arrangements specially adapted to heating apparatus
• H05B 3/03 - Electrodes
• H05B 3/16 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor the conductor being mounted on an insulating base

Abstract

A conductive paste composition according to the present invention comprises: a silver-coated copper nanowire with a core-shell structure; a binder mixture containing a silicone resin binder and a hydrocarbon-based resin binder; and an organic solvent, and thus has low sheet resistance and can endure high temperatures, thereby achieving excellent conductivity and electromagnetic wave shielding characteristics. Furthermore, the conductive paste can be easily manufactured into a planar conductive film through a simple process, and the conductive film can be widely used in various fields, such as electromagnetic wave shielding, solar cell electrodes, electronic circuits, antennas, and the like.

IPC Classes  ?

• H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys
• H01B 5/14 - Non-insulated conductors or conductive bodies characterised by their form comprising conductive layers or films on insulating-supports
• C08K 3/08 - Metals
• C08L 1/02 - Cellulose; Modified cellulose
• C08L 33/00 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters,; Compositions of derivatives of such polymers
• C08J 5/18 - Manufacture of films or sheets

Abstract

The present invention relates to the structure of an analysis plate applied to a high-speed polymerase chain reaction (PCR), and to a PCR analysis plate used for implementing an analysis of a real-time PCR, a real-time nested PCR and a post-PCR lateral flow hybridization reaction. The present invention is provided with: a check valve for enabling the maintaining of positive pressure when an elastic film expands into a convex form by having a solution pushed therein by the positive pressure; a lateral flow analysis module for analyzing a post-PCR follow-up PCR or lateral flow; and a shut-off valve enabling the controlling of the movement of the solution after each reaction ends. A high-speed PCR analysis plate may be provided whereby, by pressing, by means of a temperature-controllable heating block, the elastic film, which is in a convex form by the solution, of a PCR unit, a PCR solution may undergo rapid temperature circulation with minimum heat resistance, and a PCR dried material and a nucleic acid solution may be homogenized and mixed.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

The present invention relates to a double-helix oligonucleotide construct comprising a double-stranded miRNA and a composition for preventing or treating cancer comprising the same. More particularly, the present invention relates to a double-helix oligonucleotide construct comprising miR-544a characterized by a method that effectively inhibits the proliferation of cancer cells or induces a voluntary death of cancer cells, and an anticancer composition comprising the construct.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a system structure capable of detecting, in real time, nucleic acid extraction and amplification reactions and amplified products in an apparatus for implementing a polymerase chain reaction, the system structure comprising: a nucleic acid extraction cartridge for extracting nucleic acids from a biological sample with a nucleic acid extraction reagent stored therein, or preparing a PCR premix by additionally mixing the nucleic acids with a dried product of the polymerase chain reaction; a PCR plate which is inserted into the nucleic acid extraction cartridge and coupled thereto such that a flow path is connected therebetween, and which receives a nucleic acid solution or a PCR premix, which is extracted from the nucleic acid extraction cartridge, and dispenses and accommodates same in at least one reaction well having accommodated therein dried primers/probes, or a dried PCR product comprising primers/probes; a temperature control module provided on the PCR plate and comprising a pair of heating blocks which are adjacent to the reaction well (W) and apply different temperatures; and a scanning module provided below the PCR plate to scan the concentration of a reaction product amplified in the reaction well (W).

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

Abstract

A bio sample collection device including: a housing; a cap part detachably fastened to the housing, and including a bio sample collector for collecting a bio sample; and a bio sample processing liquid storage unit storing bio sample processing liquid, the bio sample processing liquid storage unit being formed to be broken when the cap part is combined with the housing after bio sample is collected so that the bio sample processing liquid is mixed with the bio sample.

IPC Classes  ?

• G01N 1/02 - Devices for withdrawing samples
• A61B 10/02 - Instruments for taking cell samples or for biopsy
• C12M 1/26 - Inoculator or sampler

Abstract

The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle which can be produced through self-assembly of the double-stranded oligonucleotide construct by a hydrophobic interaction in an aqueous solution; and a hair loss-preventing and hair growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide; a nanoparticle; and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention highly efficiently suppress the expression of DKK1 without side effects, and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 9/14 - Particulate form, e.g. powders
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

A sample concentrator tube having a heat-resistant planar heating element adhered thereto, an analysis device comprising same, and an analysis method using same, according to the present invention, have an effect capable of precisely controlling the temperature by heating the sample concentrator tube uniformly and rapidly to a target temperature for desorption, and of desorbing an adsorbed sample almost simultaneously in any part of an adsorbent by minimizing the local temperature difference of the adsorbent in the tube. In addition, it is possible to minimize chemical noise by preventing thermal denaturation of the adsorbent caused by overheating, and there is an advantage of excellent reproducibility as well as an effect of being inexpensive, economical, and excellent in energy efficiency.

IPC Classes  ?

• G01N 1/40 - Concentrating samples
• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• H05B 3/20 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater
• H05B 3/40 - Heating elements having the shape of rods or tubes

Abstract

A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size.

IPC Classes  ?

• G01N 30/30 - Control of physical parameters of the fluid carrier of temperature
• H05B 3/16 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor the conductor being mounted on an insulating base
• H05B 3/14 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material the material being non-metallic
• G01N 30/02 - Column chromatography

Abstract

a and miR-8078, and characterized by a method for effectively inhibiting cancer cell proliferation or inducing cancer cell apoptosis; and a pharmaceutically acceptable carrier.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/00 - Antineoplastic agents
• A61K 31/25 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to: a double stranded oligonucleotide construct having a structure of the form in which a hydrophilic material and a hydrophobic material are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a double stranded oligonucleotide in order to efficiently deliver an androgen receptor specific oligonucleotide into a cell; a nanoparticle which can be produced by self-assembling the double stranded oligonucleotide constructs in an aqueous solution by hydrophobic interaction; and a composition for preventing hair loss or for promoting hair growth comprising the double stranded oligonucleotide construct. The double stranded oligonucleotide construct comprising an androgen receptor specific oligonucleotide, and the composition for preventing hair loss or for promoting hair growth comprising the same as an active ingredient, according to the present invention, can inhibit the expression of an androgen receptor with high efficiency without side effects, and thus can have an excellent effect on the prevention of hair loss, especially androgenic hair loss, alopecia areata, and telogen alopecia and the promotion of hair growth.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• A61K 8/60 - Sugars; Derivatives thereof
• A61K 8/86 - Polyethers
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds

Abstract

A double stranded oligonucleotide construct having a structure of Structural Formula (1): A-X-R-Y-B Structural Formula (1), is provided for preventing hair loss or promoting hair growth. In Structural Formula (1), wherein A is a hydrophilic material, B is a hydrophobic material, each of X and Y independently represents a covalent bond or a linker-mediated covalent bond, and R represents an androgenreceptor-specific oligonucleotide comprising a sense strand comprising SEQ ID NO: 68 or 109 and an antisense strand comprising a sequence complementary thereto.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 8/60 - Sugars; Derivatives thereof
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• A61K 8/86 - Polyethers
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

The present invention relates to a probe having octamine or octamine derivative bound thereto in addition to a reporter and a quencher to thus allow the quencher to more effectively suppress light emitted by the reporter, and to uses of the probe. When the probe according to the present invention is utilized, octamine or octamine derivative bound to the probe effectively suppresses the light emitted by the quencher for the reporter, and results in effects such as i) a reduction in base fluorescence, ii) an increase in delta fluorescence, and iii) a decrease in the value of cycle at threshold, thus allowing the probe to be effectively used in a variety of real-time polymerase chain reactions requiring accuracy and sensitivity.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The present invention relates to an epoxy paste composition including silver-coated copper nanowires having a core-shell structure, and a conductive film including the same.

IPC Classes  ?

• C09D 5/24 - Electrically-conducting paints
• H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys
• B32B 5/16 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer formed of particles, e.g. chips, chopped fibres, powder
• H01B 1/02 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of metals or alloys
• C08K 9/02 - Ingredients treated with inorganic substances
• C08K 3/08 - Metals
• C09D 163/00 - Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
• H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

Abstract

The present invention relates to an extraction apparatus capable of simultaneously extracting target materials from multiple biological samples and, more particularly, to a target material extraction apparatus in which magnetic bar blocks can be replaced according to kinds of multi-well plates to be inserted into a cartridge. When used, the target material extraction apparatus of the present invention is operated in such a manner that among various multi-well plates having different numbers of wells, multi-well plates suitable for a use purpose are loaded into a cartridge within the apparatus and magnetic bar blocks equipped with magnetic bars suitable therefor are selected and loaded. Thus, the apparatus has the advantage of selectively applying various multi-well plates to one installment according to the number of samples from which a target material is extracted or to the amount of the target material to be extracted.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

Abstract

The present invention relates to a method for preparing highly active silica magnetic nanoparticles, highly active silica magnetic nanoparticles prepared by the method, and a method of isolating nucleic acid using the highly active silica magnetic nanoparticles. The highly active silica magnetic nanoparticles prepared according to the present invention contain magnetic nanoparticles completely coated with silica, can be used as a reagent for isolating biomaterials, particularly, nucleic acids, and can isolate and purify nucleic acid in a high yield.

IPC Classes  ?

• H01F 1/06 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
• C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof

Abstract

A sample plate for MALDI mass spectrometry, according to the present invention, enables separately positioning, by means of a plastic insulation plate, metal wiring and metal dots onto which an analyte sample is to be loaded, and electrically connecting same by means of a via or a metal portion, and thus the energy transferred into the plate when radiating a laser beam on the target (metal dots) may be reduced compared to a sample plate using a base metal, and thus laser energy may be concentrated on the target, and an effect may be achieved whereby heat loss is minimized.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/34 - Dynamic spectrometers

Abstract

The present invention relates to an ion guide for transferring ions to a mass spectrometer. The ion guide of the present invention is characterized in that a plurality of DC rings and a plurality of RF multi-pole rings with a plurality of electrodes are arranged so as to intersect with each other between an inlet into which the ions move and an outlet for transferring the ions, wherein the inner diameter of the DC rings is kept constant and the inner diameter of the RF multi-pole rings gradually decreases in a direction from the inlet to the outlet.

IPC Classes  ?

• H01J 49/06 - Electron- or ion-optical arrangements
• H01J 49/10 - Ion sources; Ion guns
• H01J 49/26 - Mass spectrometers or separator tubes

Abstract

An electric roasting pan according to the present invention comprises: a roasting pan; a heating layer being in surface contact with the roasting pan and comprising a carbon nanotube and a silicone-based adhesive; and an electrode in contact with the heating layer. The electric roasting pan has excellent thermal efficiency thanks to the minimal heat loss thereof, can reach a target temperature within a short time to reduce a preheating time, and affords excellent cooking quality. Furthermore, the electric roasting pan can substantially prevent the occurrence of temperature deviation across the area of the roasting pan during a temperature increase and is of high durability and safety.

IPC Classes  ?

• A47J 37/10 - Frying pans, e.g. frying pans with integrated lids or basting devices
• A47J 36/02 - Selection of specific materials, e.g. heavy bottoms with copper inlay or with insulating inlay
• H05B 3/14 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material the material being non-metallic
• H05B 3/20 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater

Abstract

The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 11/06 - Antiasthmatics
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 11/06 - Antiasthmatics
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to the structure of an analysis plate applied to a high-speed polymerase chain reaction (PCR), and to a PCR analysis plate used for implementing an analysis of a real-time PCR, a real-time nested PCR and a post-PCR lateral flow hybridization reaction. The present invention is provided with: a check valve for enabling the maintaining of positive pressure when an elastic film expands into a convex form by having a solution pushed therein by the positive pressure; a lateral flow analysis module for analyzing a post-PCR follow-up PCR or lateral flow; and a shut-off valve enabling the controlling of the movement of the solution after each reaction ends. A high-speed PCR analysis plate may be provided whereby, by pressing, by means of a temperature-controllable heating block, the elastic film, which is in a convex form by the solution, of a PCR unit, a PCR solution may undergo rapid temperature circulation with minimum heat resistance, and a PCR dried material and a nucleic acid solution may be homogenized and mixed.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

The present invention relates to a matrix-assisted laser desorption ionization mass spectrometry method and, specifically, a mass spectrometry method according to the present invention comprises the steps of: acquiring a mass spectrum of an analyte by performing matrix-assisted laser desorption ionization of the analyte, wherein a detection spectrum, which is the mass spectrum of the analyte, is acquired using each of two or more matrixes different from one another; and removing, from each detection spectrum, a peak of a corresponding matrix to obtain a matrix-removed spectrum, and then acquiring a corrected mass spectrum of the analyte on the basis of a matrix-removed spectrum for each of different matrixes.

IPC Classes  ?

• H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/10 - Ion sources; Ion guns

Abstract

A gas sample analysis apparatus and a gas sample analysis method, according to the present invention, can estimate a flow rate and a time enabling a gas sample to be concentrated to a gas sample concentration suitable for analysis, that is, a required concentration amount, thereby remarkably reducing total analysis time including gas sample concentration time, and can allow a suitable amount of a sample required for quantitative analysis to be concentrated and analyzed, thereby increasing analysis accuracy and preventing a problem in which overall analysis efficiency deteriorates.

IPC Classes  ?

• G01N 30/06 - Preparation
• G01N 1/22 - Devices for withdrawing samples in the gaseous state
• G01N 1/40 - Concentrating samples
• G01N 30/72 - Mass spectrometers

Abstract

The present invention relates to a double-helix oligonucleotide construct comprising a double-stranded miRNA and a composition for preventing or treating cancer comprising the same. More particularly, the present invention relates to a double-helix oligonucleotide construct comprising miR-544a characterized by a method that effectively inhibits the proliferation of cancer cells or induces a voluntary death of cancer cells, and an anticancer composition comprising the construct.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61P 35/00 - Antineoplastic agents

Abstract

A biological sample processing apparatus, including: a pipette block with which a plurality of pipettes for sucking or discharging a biological sample in a multi-well plate in which wells are arranged in a matrix shape along row and column directions are detachably coupled; a pipette block forward and backward transfer unit configured to move the pipette block along a forward and backward direction along a process direction; a pipette block top and bottom transfer unit configured to move the pipette block along a vertical direction; a magnetic field applying unit disposed below the multi-well plate for applying a magnetic field to a well of the multi-well plate; and a heating unit disposed below the multi-well plate so as to be spaced apart from the magnetic field applying unit, for heating a well of the multi-well plate.

IPC Classes  ?

• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• B01L 3/02 - Burettes; Pipettes

Abstract

The present invention relates to a pharmaceutical composition for treatment of cancer, which comprises, as an active ingredient, one or more miRNAs selected from the group consisting of miR-3670, miR-8078, and miR-4477a. The pharmaceutical composition for treatment of cancer according to the present invention exhibits excellent effects of inhibiting cancer cell proliferation and inducing cancer cell apoptosis. Thus, the pharmaceutical composition of the present invention can be effectively used as an anticancer therapeutic agent.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a device which is easy to use and in which real-time reaction product detection through nucleic acid extraction from a biospecimen, a PCR reaction, and scanning of excitation light of various wavelengths and fluorescence corresponding thereto can be automated, various tests can be carried out in a single operation, and in particular, accurate results can be obtained in a short amount of time.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

A biosample collection device capable of accurately examining a biosample is disclosed. The biosample collection device comprises a housing, a cap part and a biosample treatment solution storing part. The cap part is fastened to the housing so as to be detachable therefrom, and has a biosample collection part for collecting a biosample. The biosample treatment solution storing part stores a biosample treatment solution, and is damaged when the cap part is fastened to the housing after the biosample is collected by the biosample collection part, so as to mix the biosample treatment solution with the biosample.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy
• C12M 1/26 - Inoculator or sampler
• G01N 1/04 - Devices for withdrawing samples in the solid state, e.g. by cutting
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Goods & Services

Anti-diabetic functional lactic acid bacteria for use in food manufacture Microorganisms for medical purposes, namely, the treatment of obesity, Microorganisms for medical purposes, namely, the treatment of obesity, diabetes, atopy, visceral fat decrease; Probiotic microorganisms for medical purposes, namely, the treatment of obesity, diabetes, atopy, visceral fat decrease; Lactic acid bacterial preparations for medical use, namely, functional lactic acid bacteria for body fat breakdown and anti-obesity, functional lactic acid bacteria for improving immunity, functional lactic acid bacteria for improving skin diseases and atopic diseases and functional lactic acid bacteria for improving intestinal function and irritable colon symptoms; Medicines for the prevention and treatment of obesity, immune disorder, skin diseases, atopic diseases and intestinal disorders for veterinary purposes; Health food supplements based on milk for medical use containing probiotics in capsule, tablet and powder form; Dietary supplements containing probiotics for medical purposes in capsule, tablet, and powder form; Dietary supplements

Abstract

The present invention relates to a display device for a matrix-assisted laser desorption ionization mass spectrum. Specifically, the display device, according to the present invention, comprises: a storage unit which stores data including information on the mass-to-charge ratio (m/z) of matrix-derived ions for each matrix and an original mass spectrum which is a mass spectrum acquired by means of the matrix-assisted laser desorption ionization of an analyte; an input unit which receives, as input, information on a matrix material used when acquiring the original mass spectrum; a signal processing unit which receives the information on the matrix material inputted into the input unit, is linked with the storage unit, and according to the information on the matrix material inputted via the input unit, removes, from the original mass spectrum, a peak corresponding to the mass-to-charge ratio (m/z) of matrix-derived ions of the corresponding matrix material, thereby generating a noise-removed mass spectrum which is a mass spectrum having noise removed therefrom; and an output unit which receives the noise-removed mass spectrum from the signal processing unit and outputs same.

IPC Classes  ?

• G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
• H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Abstract

A sample plate for MALDI mass spectrometry, according to the present invention, enables separately positioning, by means of a plastic insulation plate, metal wiring and metal dots onto which an analyte sample is to be loaded, and electrically connecting same by means of a via or a metal portion, and thus the energy transferred into the plate when radiating a laser beam on the target (metal dots) may be reduced compared to a sample plate using a base metal, and thus laser energy may be concentrated on the target, and an effect may be achieved whereby heat loss is minimized.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• G01N 1/40 - Concentrating samples

Goods & Services

biological enzymes for non-medical use; compositions for use in cDNA synthesis for research purposes; kits for use in cDNA synthesis for research purposes comprised of reagents, buffers, reverse transcriptase, oligomer; compositions for use in nucleic acid fluorescence staining for research purposes; kits for use in nucleic acid fluorescence staining for research purposes consisting of reagents, buffers, staining reagents; compositions for use in DNA sequence analysis for research purposes; kits for use in DNA sequence analysis for research purposes consisting of reagents, buffers, DNA polymerase; nucleic acid polymerase for research purposes; compositions for use in nucleic acid amplification for research purposes; kits for use in nucleic acid amplification for research purposes consisting of reagents, buffers, nucleic acid polymerase; chemical reagents for research purposes; compositions for use in polymerase chain reaction for research purposes; compositions for use in reverse transcription for research purposes. biological enzymes for medical use; kits for use in cDNA synthesis for medical purposes comprised of reagents, buffers, reverse transcriptase, oligomer; compositions for use in nucleic acid fluorescence staining for medical purposes; kits for use in nucleic acid fluorescence staining for medical purposes consisting of reagents, buffers, staining reagents; compositions for use in DNA sequence analysis for medical purposes; kits for use in DNA sequence analysis for medical purposes consisting of reagents, buffers, DNA polymerase; nucleic acid polymerase for medical purposes; compositions for use in nucleic acid amplification for medical purposes; kits for use in nucleic acid amplification for medical purposes consisting of reagents, buffers, nucleic acid polymerase; chemical reagents for medical purposes; compositions for use in reverse transcription for medical purposes.

Goods & Services

biological enzymes for non-medical use; compositions for use in cDNA synthesis for research purposes; kits for use in cDNA synthesis for research purposes comprised of reagents, buffers, reverse transcriptase, oligomer; compositions for use in nucleic acid fluorescence staining for research purposes; kits for use in nucleic acid fluorescence staining for research purposes consisting of reagents, buffers, staining reagents; compositions for use in DNA sequence analysis for research purposes; kits for use in DNA sequence analysis for research purposes consisting of reagents, buffers, DNA polymerase; nucleic acid polymerase for research purposes; compositions for use in nucleic acid amplification for research purposes; kits for use in nucleic acid amplification for research purposes consisting of reagents, buffers, nucleic acid polymerase; chemical reagents for research purposes; compositions for use in polymerase chain reaction for research purposes; compositions for use in reverse transcription for research purposes biological enzymes for medical use; kits for use in cDNA synthesis for medical purposes comprised of reagents, buffers, reverse transcriptase, oligomer; compositions for use in nucleic acid fluorescence staining for medical purposes; kits for use in nucleic acid fluorescence staining for medical purposes consisting of reagents, buffers, staining reagents; compositions for use in DNA sequence analysis for medical purposes; kits for use in DNA sequence analysis for medical purposes consisting of reagents, buffers, DNA polymerase; nucleic acid polymerase for medical purposes; compositions for use in nucleic acid amplification for medical purposes; kits for use in nucleic acid amplification for medical purposes consisting of reagents, buffers, nucleic acid polymerase; chemical reagents for medical purposes; compositions for use in nucleic acid amplification for medical purposes; compositions for use in reverse transcription for medical purposes

Abstract

The present invention relates to a lactic acid bacterium isolated from human mother's milk, more precisely a Lactobacillus gasseri BNR17 strain that is isolated from Korean mother's milk and has excellent probiotic activity including acid resistance, bile acid resistance and antimicrobial activity and weight gaining inhibitory effect as well. Again, the Lactobacillus gasseri BNR17 of the present invention has excellent acid resistance, bile acid resistance, enteric absorption activity and antimicrobial activity against pathogenic microorganisms, in addition to the weight gaining inhibitory effect by synthesizing indigestible polysaccharides from monosaccharides included in food taken and releasing the synthesized polysaccharides out of the body. Therefore, the strain of the invention, owing to such beneficiary effects, can be effectively used not only for the production of fermented milk, other fermented food products and animal feeds but also for the production of live cell products and food additives for preventing weight gaining.

IPC Classes  ?

• A61K 35/74 - Bacteria
• C12N 1/20 - Bacteria; Culture media therefor
• C12R 1/225 - Lactobacillus
• A23L 33/18 - Peptides; Protein hydrolysates
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23C 9/123 - Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
• C07K 14/335 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to a sample plate for matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry, and a mass spectrometry method using the same. The sample plate according to the present invention comprises: a conductive substrate; and an organic matrix region which is formed on one surface of the conductive substrate, and in which two or more different organic matrices are arranged so as to be spaced apart from one another.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Abstract

The present invention relates to a matrix-assisted laser desorption ionization mass spectrometry method and, specifically, a mass spectrometry method according to the present invention comprises the steps of: acquiring a mass spectrum of an analyte by performing matrix-assisted laser desorption ionization of the analyte, wherein a detection spectrum, which is the mass spectrum of the analyte, is acquired using each of two or more matrixes different from one another; and removing, from each detection spectrum, a peak of a corresponding matrix to obtain a matrix-removed spectrum, and then acquiring a corrected mass spectrum of the analyte on the basis of a matrix-removed spectrum for each of different matrixes.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/16 - Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/10 - Ion sources; Ion guns

Abstract

The present invention relates to an epoxy paste composition including silver-coated copper nanowires having a core-shell structure, and a conductive film including the same.

IPC Classes  ?

• C08K 7/02 - Fibres or whiskers
• C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• C08K 3/08 - Metals
• C08K 5/00 - Use of organic ingredients
• C09D 7/00 - Features of coating compositions, not provided for in group ; Processes for incorporating ingredients in coating compositions
• C09D 163/00 - Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
• C08J 5/18 - Manufacture of films or sheets

Abstract

Disclosed is a biological sample processing apparatus capable of facilitating application and release of a magnetic field. Such a biological sample processing apparatus comprises a pipette block, a pipette block forward and backward delivery unit, a pipette block vertical delivery unit, a magnetic field application unit, and a heating unit. The pipette block is coupled in such a manner that a plurality of pipettes for sucking or discharging biological samples in a multi-well plate can be detached, wherein wells are arranged in a matrix shape along the row and column directions in the multi-well plate. The pipette block forward and backward delivery unit moves the pipette block along the forward and backward directions which are process processing directions. The pipette block vertical delivery unit moves the pipette block along the vertical direction. The magnetic field application unit is disposed below the multi-well plate, and applies a magnetic field to some wells of the multi-well plate. The heating unit is disposed below the multi-well plate so as to be spaced apart from the magnetic field application unit, and heats some wells of the multi-well plate.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The present invention relates to a double-stranded oligo RNA structure comprising double-stranded miRNA, and a composition for preventing or treating cancer, containing the same. More specifically, the present invention relates to an anti-cancer pharmaceutical composition, containing: a double-stranded oligo RNA structure comprising miR-3670, miR-4477a and miR-8078, and characterized by a method for effectively inhibiting cancer cell proliferation or inducing cancer cell apoptosis; and a pharmaceutically acceptable carrier.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links

Abstract

The present invention relates to a silver-coated copper nanowire having a core-shell structure by using a chemical reduction method, and a manufacturing method therefor and, more specifically, to: a method for manufacturing a silver-coated copper nanowire, comprising a step of manufacturing a copper nanowire by a chemical method, and then coating the surface of copper through a chemical reduction method by using a silver nitrate-ammonia complex solution and a reducing agent in order to prevent the oxidation of the copper nanowire; and a silver-coated copper nanowire, having a core-shell structure, manufactured by the method. In addition, costs can be reduced since the copper nanowire can be reproduced by reusing a solution. According to the present invention, since the oxidation of the silver-coated copper nanowire having a core-shell structure is prevented even in air or at a high temperature, electrical conductivity does not deteriorate, and thus the silver-coated copper nanowire having a core-shell structure is useful in the manufacture of an electromagnetic interference-shielding paste or a highly conductive paste, which requires a high electrical conductivity.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• B22F 1/02 - Special treatment of metallic powder, e.g. to facilitate working, to improve properties; Metallic powders per se, e.g. mixtures of particles of different composition comprising coating of the powder

Abstract

The present invention relates to an oligonucleotide structure and a method for preparing the same and, more particularly, to an oligonucleotide structure in which a polymer compound is linked to an oligonucleotide via a covalent bond to improve in vivo stability of the oligonucleotide and cellular delivery efficiency of the oligonucleotide; and to a method for preparing the same. The oligonucleotide structure is improved into a homogenous material, thereby solving the problem in material verification due to polydispersion characteristics occurring when a hydrophilic material linked to the oligonucleotide is a synthetic polymer; the oligonucleotide structure is easy to synthesize compared with the existing process; and the size of a double-stranded oligo RNA structure can be accurately adjusted through the control of the repetition number of a hydrophilic material block, and thus, the gene expression regulation function of the oligonucleotide does not deteriorate through the synthesis of the optimized oligonucleotide structure, and the oligonucleotide can be delivered into cells at even a relatively low-concentration dosage. Therefore, the oligonucleotide structure of the present invention can be useful as a novel type oligonucleotide delivery system as well as a tool for treating cancers, infectious diseases, and the like.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/51 - Nanocapsules
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

Abstract

The present invention relates to a novel siRNA, and a high-efficiency double-stranded oligo RNA structure containing the same, and a nanoparticle containing the high-efficiency double-stranded oligo RNA structure. The double-stranded oligo RNA structure has a structure in which a hydrophilic material and a hydrophobic material are conjugated to both ends of a double-stranded oligo RNA (siRNA) via a simple covalent bond or linker-mediated covalent bond in order to be efficiently delivered into cells, and may be converted into a nanoparticle form in an aqueous solution by hydrophobic interactions of double-stranded oligo RNA structures. It is preferable that the siRNA contained in the double-stranded oligo RNA structure is an siRNA specific for fibrosis or respiratory disease-related gene, particularly, amphiregulin or stratifin. In addition, the present invention relates to a pharmaceutical composition for preventing or treating fibrosis or respiratory diseases, containing an siRNA, a high-efficiency double-stranded oligo RNA structure containing the siRNA, or a nanoparticle containing the high-efficiency double-stranded oligo RNA structure, as an active ingredient. In addition, the present invention relates to a method of preventing or treating fibrosis or respiratory diseases, including administering the pharmaceutical composition for preventing or treating fibrosis or respiratory diseases to a subject in need thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention provides a novel azo compound having a quenching ability for the material that exhibits a luminescent phenomenon at an excited energy level, a quencher comprising the novel azo compound, a use of the quencher and a method for preparing the azo compound. The quencher according to the present invention may exhibit excellent characteristics in a wavelength absorption region.

IPC Classes  ?

• C09B 31/14 - Heterocyclic components
• C07D 213/72 - Nitrogen atoms
• C07D 277/82 - Nitrogen atoms
• C09B 31/153 - Heterocyclic components containing a six-membered ring with one nitrogen atom as the only ring hetero atom
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Goods & Services

(1) Microorganisms for use in food manufacture; Probiotic microorganisms for use in food manufacture; Lactic acid bacteria for use in food manufacture; Chemical substances for preserving foodstuffs (2) Food for babies (except lacteal flour for babies); Milk sugar for pharmaceutical purposes; Pharmaceutical preparations , namely, elixirs for the treatment of obesity, diabetes, atopy and for decreasing visceral fat; Lacteal flour for babies; Microorganisms for medical purposes, namely, the treatment of obesity, diabetes, atopy, visceral fat decrease; Probiotic microorganisms, namely, the treatment of obesity, diabetes, atopy, visceral fat decrease; Anti-diabetic functional lactic acid bacteria; Functional lactic acid bacteria for body fat breakdown and anti-obesity; Functional lactic acid bacteria for improving immunity; Functional lactic acid bacteria for improving skin diseases and atopic diseases; Functional lactic acid bacteria for improving intestinal function and irritable colon symptoms; Medicines for veterinary purposes for the treatment of obesity, diabetes, atopy, visceral fat decrease; Baby food made from livestock products; Dietetic beverages adapted for medical purposes, namely, dietary supplemental beverage for treating obesity, diabetes, atopy and decreasing visceral fat; Dietetic foods adapted for medical purposes, namely, pasta and crackers for treating obesity, diabetes, atopy and decreasing visceral fat; Medicated confectionery, namely, confectionery for treating obesity, diabetes, atopy and decreasing visceral fat; Medicinal drinks for treating obesity; Health supplement foods based on milk for medical use, namely, probiotics in capsule, tablet and powder form; Dietary supplements for medical purposes, namely, probiotics in capsule, tablet and powder form (3) Milk; Processed dairy products; Butter; Buttercream; Cheese; Fermented milk; Yoghurt; Ice cream; Powdered milk; Fresh cream; Sour; Unripened cheese; Soft cheese; Drinks based on yoghurt; Lactic acid bacteria drinks; Milk products; Cheese spread; Whipped Cream; Nutritional foods based on milk, namely, yogurt; Health supplement foods , namely, milk-based health drinks (4) Starch for food; Processed cereal-based food to be used as a breakfast food, snack food, or ingredient for making other foods; Cereal-based processed products, namely, energy bar and snack food; Confectioneries, namely, chocolate; Donuts, Scones, Candied Nuts; Bread; Gum; Candy; Chocolate; Tea; Coffee; Cocoa; Soy sauce and soy bean paste; Sugar for food; Tea-based beverages; Drinks based on tea; Ready-to-eat cereals; Preparations for stiffening whipped cream

Goods & Services

Microorganisms other than for medical and veterinary use; Probiotic microorganisms; Lactic acid bacteria;   Cultures of microorganisms other than for medical and veterinary use; Chemical substances for preserving foodstuffs. Food for babies (except lacteal flour for babies); Milk sugar for pharmaceutical purposes; Pharmaceutical preparations; Lacteal flour for babies; Microorganisms for medical purposes; Probiotic microorganisms; Lactic acid bacteria; Anti-diabetic functional lactic acid bacteria; Functional lactic acid bacteria for body fat breakdown and anti-obesity; Functional lactic acid bacteria for improving immunity; Functional lactic acid bacteria for improving skin diseases and atopic diseases; Functional lactic acid bacteria for improving intestinal function and irritable colon symptoms; Medicines for veterinary purposes; Baby food made from livestock products; Dietetic beverages adapted for medical purposes; Dietetic foods adapted for medical purposes; Medicated confectionery; Medicinal drinks; Nutritional foods based on milk for medical use; Health supplement foods based on milk for medical use; Health supplement foods based on milk other than for medical use; Dietary supplements for medical purposes. Milk; Processed dairy products; Butter; Buttercream; Food products made from oil and fat; Cheese; Fermented milk; Yoghurt; Powdered milk; Fresh cream; Sour cream; Sour milk; Unripened cheese; Soft cheese; Drinks based on yoghurt; Lactic acid bacteria drinks; Milk products; Cheese spread; Whipped Cream; Nutritional foods based on milk other than for medical use. Starch for food; Processed cereals; Cereal-based processed products; Confectionery; Bread; Gum; Candy; Chocolate; Tea; Coffee; Cocoa; Soy sauce and soy bean paste; Sugar for food; Tea-based beverages; Drinks based on tea; Cereal; Preparations for stiffening whipped cream; Icecream.

Abstract

The present invention relates to a magnetic particle separating device, and a method of separating and purifying nucleic acid or protein using the same. The device comprises: induction magnets (100); an induction magnet fixing part (200) having induction magnet fixing holes (210) for fixing the induction magnets (100); and a body (300) in which entry holes (310) are formed into which tubes (T) are inserted. Thus, the application and removal of a magnetic field to and from the body is made very convenient, so that the device can be very advantageously used in the separation and purification of nucleic acid or protein.

IPC Classes  ?

• B03C 1/01 - Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 1/40 - Concentrating samples
• B03C 1/28 - Magnetic plugs and dipsticks
• B03C 1/033 - Component parts; Auxiliary operations characterised by the magnetic circuit

Abstract

The present invention relates to: a STAT3 gene specific siRNA; a highly efficient double-helical oligo RNA structure including the same; a pharmaceutical composition containing the same; and a use thereof and, more particularly, to: a STAT3 gene specific siRNA; a double-helical oligo RNA structure, which includes the same and has a structure in which hydrophilic materials and hydrophobic materials are bound to both ends of the double-helical RNA (siRNA), by using a simple covalent bond or a linker-mediated covalent bond, so as to be effectively transferred into a cell; nanoparticles capable of being produced, in an aqueous solution, by hydrophobic interactions between the double-helical oligo RNA structures; a method for producing the double-helical oligo RNA structure; and a pharmaceutical composition for preventing or treating cancers, especially breast cancer, skin diseases including psoriasis, or inflammatory diseases, containing the double-helical oligo RNA structure. According to the present invention, the STAT3 specific siRNA and the composition for treating cancers, skin diseases, or inflammatory diseases, containing the double-helical oligo RNA structure including the same can achieve a therapeutic effect on cancers, especially breast cancer, skin diseases including psoriasis, or inflammatory diseases by inhibiting the expression of STAT3 with high efficiency without causing side effects, and thus the present invention can be useful in treating breast cancer, skin diseases, or inflammatory diseases for which there currently is no suitable therapeutic agent.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The present invention relates to a method for preparing highly active silica magnetic nanoparticles, highly active silica magnetic nanoparticles prepared by the method, and a method of isolating nucleic acid using the highly active silica magnetic nanoparticles. The highly active silica magnetic nanoparticles prepared according to the present invention contain magnetic nanoparticles completely coated with silica, can be used as a reagent for isolating biomaterials, particularly, nucleic acids, and can isolate and purify nucleic acid in a high yield.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
• H01F 1/06 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
• C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof