Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagent paper, other than for medical or veterinary
purposes; chemical reagents and chemical preparations, other
than for medical or veterinary use; testing reagents and
preparations other than for medical or veterinary use;
chemical reference materials for scientific or research use;
chemical preparations for the quality control of testing and
calibrating scientific or laboratory apparatus; reagents for
genetic tests for non-medical use; reagents for cell
analysis tests for non-medical use; reagents for protein
analysis tests for non-medical use; biological and
biotechnological preparations, other than for medical or
veterinary purposes. Reagent paper for medical purposes; chemical reagents and
chemical preparations for medical or veterinary use;
diagnostic reagents and diagnostic preparations for medical
or veterinary use; testing reagents and preparations for
medical or veterinary use; chemical preparations for the
quality control of testing and calibrating medical or
veterinary apparatus; cleaning preparations for medical or
veterinary use; reagents for genetic tests for medical or
veterinary purposes; reagents for cell analysis tests for
medical or clinical use; reagents for protein analysis tests
for medical or clinical use; medical preparations;
biological preparations for medical purposes; cell
preparations for treatment of diseases or disorders;
antibody for medical purposes; antibody for veterinary
purposes. Electronic publications; laboratory apparatus and
instruments; measuring or testing machines and instruments
for scientific, research or laboratory use; testing
apparatus and instruments for scientific, research or
laboratory use; laboratory analyzers for measuring, testing
and analyzing blood or other body fluids; flow cytometers
for scientific or laboratory use; particle analyzers for
scientific, research or laboratory use; particle counters
for scientific, research or laboratory use; test tubes for
scientific, research or laboratory use; pipette tips for
scientific, research or laboratory use; computers; computer
software; computer programs; computer program for use in the
field of medical, clinical or diagnostic analysis; computer
programs for use in the field of scientific or laboratory
analysis; genetic testing apparatus for scientific, research
or laboratory use. Medical apparatus and instruments; diagnostic apparatus and
instruments for medical use; measurement apparatus and
instrument for medical use; medical or veterinary apparatus
and instruments; testing apparatus and instruments for
medical or clinical use; diagnostic apparatus and
instruments for medical or clinical use; flow cytometers for
medical or clinical use; particle analyzers for medical or
clinical use; particle counters for medical or clinical use;
measuring or testing machines and instruments for medical or
clinical use; in-vitro diagnostic sample container for
medical purposes; blood testing apparatus; surgical
apparatus and instruments; surgical robots, and machines and
instruments therefor; surgical robots; gloves for medical
purposes; pipettes for medical analysis; sampling bottles
for medical analysis (container for medical purposes);
disposable beakers for medical analysis (container for
medical purposes); genetic testing apparatus and instruments
for medical or clinical use; cell analysis apparatus and
instruments for medical or clinical use; protein analysis
apparatus and instruments for medical or clinical use. Installation, repair and maintenance of computers and
computer peripheral equipment; providing information
relating to installation, repair and maintenance of
computers and computer peripheral equipment; installation,
repair and maintenance of medical apparatus and instruments;
providing information relating to installation, repair and
maintenance of medical apparatus and instruments;
installation, repair and maintenance of medical or
veterinary robots and their parts and accessories; repair
and maintenance of medical or veterinary robots and their
parts and accessories by remote operation; providing
information relating to installation, repair and maintenance
of medical or veterinary robots and their parts and
accessories; installation, repair and maintenance of
measuring and testing apparatus and instruments; providing
information relating to installation, repair and maintenance
of measuring and testing apparatus and instruments;
installation, repair and maintenance of data processing
apparatus and instruments; providing information relating to
installation, repair and maintenance of data processing
apparatus and instruments; installation, repair and
maintenance of electronic machines, apparatus and their
parts; providing information relating to installation,
repair and maintenance of electronic machines, apparatus and
their parts; installation, repair and maintenance of
laboratory apparatus and instruments; providing information
relating to installation, repair and maintenance of
laboratory apparatus and instruments; remote monitoring by
computer system for repair or maintenance of medical
apparatus and instruments; remote monitoring by computer
system for repair or maintenance of surgical apparatus and
instruments; remote monitoring by computer system for repair
or maintenance of measuring or testing apparatus and
instruments; remote monitoring by computer system for repair
or maintenance of electronic machines, apparatus and their
parts; remote monitoring by computer system for repair or
maintenance of laboratory apparatus and instruments; online
remote monitoring by computer system for repair or
maintenance of data processing apparatus and instruments;
online remote monitoring by computer system for repair or
maintenance of medical apparatus and their parts; online
remote monitoring by computer system for repair or
maintenance of measuring apparatus and instruments; online
remote monitoring by computer system for repair or
maintenance of electronic machines, apparatus and their
parts; online remote monitoring by computer system for
repair or maintenance of laboratory apparatus and
instruments. Rental of Internet server storage space; providing
information on rental of Internet server storage space;
systemization or maintenance of computer programs for
Internet servers; providing temporary use of
non-downloadable computer programs via Internet; providing
scientific and technological information via computer
terminal communication such as the Internet; providing
scientific and technological information via network
communication; collection, analysis, evaluation, or research
on clinical test data measured by medical apparatus, and
providing information thereof; testing, inspection,
measurement, analysis, evaluation or research on medical
apparatus and providing information thereof; testing,
inspection, measurement, analysis, evaluation, or research
on test reagents, and provision of information thereof;
rental of a storage space of a server's storage device in
communication by a computer terminal; providing scientific
and technological information; rental of measuring or
testing apparatus and instruments; technological advice
relating to computers and industrial machines; computer
programming or maintenance; rental of computers; providing
temporary use of non-downloadable computer programs; rental
of laboratory apparatus and instruments; providing
electronic storage space on the Internet; testing and
research relating to protein analysis; testing and research
relating to genetic analysis; scientific research in the
field of genetics and genetic engineering; testing services
to detect or quantify gene mutations, gene variations, gene
amplification, gene loss and gene fusion; tests,
inspections, or research on pharmaceuticals, and providing
information thereof; quality control of pharmaceuticals;
consultation and advice on the design, development, or
maintenance of computer software for medical, veterinary,
clinical testing, clinical diagnosis, or research purposes;
rental of storage space for storing electronic data in the
medical, clinical, and scientific analysis and diagnostic
fields; hosting of websites in the fields of medical,
clinical, scientific analysis and diagnostics; providing
temporary use of non-downloadable computer programs for
gathering, processing and storing data in the field of
medical, clinical or laboratory analysis; medical research;
testing, inspection, measuring, analysis, evaluation for
medical research purposes and providing information thereof;
electronic storage of medical records; consultancy in
relation to design and development of computer software,
computer hardware and technological information, computer
system analysis in the field of medical diagnostics; design,
development, programming, installation, implementation,
maintenance and updating of computer software in the field
of medical diagnostics; providing temporary use of
non-downloadable computer programs for education management
in the field of healthcare; providing temporary use of
non-downloadable computer programs for managing data of
medical analyzers; chemical research and analysis;
scientific research, analysis and planning thereof; DNA
testing and sequencing for scientific research; testing and
research relating to cell analysis; research and analysis in
laboratories; consultancy relating to quality control;
molecular biomarker analysis; providing temporary use of
non-downloadable computer programs for analysis and
diagnostics of clinical laboratories; providing temporary
use of non-downloadable computer programs for management of
clinical laboratories; clinical trials; planning and layout
design of laboratories; providing design information of
antibody modification; providing antibody modification
technologies; planning and layout design of operating rooms;
providing information on medical information, clinical test
information, and quality control via computer terminal
communication such as the internet; providing information on
medical information, clinical testing information, and
quality control via network communication; providing
information about clinical testing; providing information
about quality control of clinical testing. Providing information on health and health management
through computer terminal communication such as the
Internet; counseling, advice, guidance on health and health
management, or providing information thereof; providing
medical information; rental of medical apparatus and
instruments; providing medical information from web sites;
providing health information from web sites; providing
cancer screening services; testing services for companion
diagnostics for medical purposes; medical test, medical
diagnosis, surgery, and treatment by remote monitoring and
operation using medical and veterinary robots and their
parts and accessories; surgical assistance; providing
medical information and treatment information, and
counseling, advice thereof; medical consultations; medical
DNA screening; medical screening; genetic test for medical
purposes; medical testing; providing medical
data/information to healthcare professionals; medical
laboratory services for the analysis of samples taken from
patients; medical laboratory services for the analysis of
blood samples taken from patients; providing information in
the field of cancer prevention, screening, diagnosis and
treatment; medical testing services relating to the
diagnosis and treatment of disease; medical analysis for the
diagnosis and treatment of disease for human; medical
diagnostic testing and reporting services pertaining to the
monitoring, diagnosis and treatment of disease; clinical
laboratory testing services and reporting of test results
for medical purpose.
3.
INFORMATION PROCESSING METHOD, INFORMATION PROCESSING APPARATUS, AND TEST SYSTEM
Disclosed is an information processing method to be executed by a computer, for analysis performed by a flow cytometer capable of acquiring a test result through a test using an antibody reagent, the information processing method including: acquiring a first test result obtained through a first test performed by the flow cytometer with respect to a first specimen of a subject; acquiring a second test result obtained through a second test different from the first test with respect to a second specimen of the subject; and displaying the first test result and the second test result in association with each other.
Disclosed is an image analysis method including inputting analysis data, including information regarding an analysis target cell to a deep learning algorithm having a neural network structure, and analyzing an image by calculating, by use of the deep learning algorithm, a probability that the analysis target cell belongs to each of morphology classifications of a plurality of cells belonging to a predetermined cell group.
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
In vitro diagnostic preparations for medical purposes; reagents for clinical testing for medical or veterinary purposes; diagnostic reagents for medicinal use; chemical reagents for medical or veterinary purposes; reagents for blood analysis for medical or veterinary purposes; medical or veterinary diagnostic reagents for hematology analysis; medical or veterinary diagnostic reagents, namely sheath solutions; medical or veterinary diagnostic reagents for blood analysis, namely sheath solutions; diluents for medical or clinical diagnostic use; and diluents for blood analysis for medical or veterinary purposes.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
In vitro diagnostic preparations for medical purposes; reagents for clinical testing for medical or veterinary purposes; diagnostic reagents for medicinal use; chemical reagents for medical or veterinary purposes; reagents for blood analysis for medical or veterinary purposes; medical or veterinary diagnostic reagents for hematology analysis; medical or veterinary diagnostic reagents, namely sheath solutions; medical or veterinary diagnostic reagents for blood analysis, namely sheath solutions; diluents for medical or clinical diagnostic use; diluents for blood analysis for medical or veterinary purposes; lysing solutions or reagents for medical or veterinary use; stains for blood analysis for medical or clinical diagnostic use; control reagents for quality control for medical use; control blood for quality control of clinical testing apparatus for medical or veterinary purposes; calibrating solutions for calibrating clinical testing apparatus for medical or veterinary purposes; chemical reference materials for calibrating medical apparatus and reagents for medical or veterinary purposes; cleaning solutions for medical purposes; reagent paper for medical purposes.
7.
SOLID PHASE CARRIER, AND TARGET OBJECT MEASUREMENT KIT
A solid phase carrier (1) used to measure a target object includes a substrate (10), and a nano-structure (20) disposed on one surface of the substrate (10), wherein: the nano-structure (20) includes a plasmon excitation layer (21) which is formed from a substance capable of exciting surface plasmon resonance, and which has a nano-structure in which localized surface plasmon resonance is excited through irradiation of light, and a covering layer (25) formed from a substance that does not excite surface plasmon resonance; the plasmon excitation layer (21) has a covered region (21a) covered by the covering layer (25), and a non-covered region (21b) not covered by the covering layer (25); the non-covered region (21b) includes a hot spot in which localized surface plasmon resonance occurs; and a surface of the covering layer (25) has a lower binding affinity with respect to a specific binding substance of the target object than a surface of the plasmon excitation layer (21).
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Diagnostic reagents and diagnostic preparations for medical or veterinary purposes; Chemical reagents for medical or veterinary purposes; Testing reagents and preparations for medical or veterinary purposes; Pharmaceutical preparations for in vitro diagnosis; Reagents for genetic test for medical or veterinary purposes; Reagents for amplification and detection of genes for medical and medical diagnostic uses; Reagents for cancer recurrence prediction test for medical or veterinary purposes; Reagents for protein test for medical or veterinary purposes; Reagents for lymph nodes test for medical or veterinary purposes; Diluents for medical or clinical diagnostic use; Diluents for genetic test for medical or veterinary purposes.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Diagnostic reagents and diagnostic preparations for medical or veterinary purposes; Chemical reagents for medical or veterinary purposes; Testing reagents and preparations for medical or veterinary purposes; Pharmaceutical preparations for in vitro diagnosis; Reagents for genetic test for medical or veterinary purposes; Reagents for amplification and detection of genes for medical and medical diagnostic uses; Reagents for cancer recurrence prediction test for medical or veterinary purposes; Reagents for protein test for medical or veterinary purposes; Reagents for lymph nodes test for medical or veterinary purposes; Reagent kits comprising RNA primers, enzymes, control materials, calibrators for use in genetic testing; Reference control materials for medical use; Chemical reference materials for medical use; Quality control standard solutions and quality control reagents for testing and calibrating medical apparatus and reagents
10.
MEDICAL ROBOT SYSTEM, DATA ANALYSIS APPARATUS, AND MEDICAL-ROBOT MONITORING METHOD
Disclosed is a medical robot system including medical robots placed at different locations and a data analysis apparatus. Each of the medical robots includes a controller that transmits data on a state of operation of the medical robot to the data analysis apparatus. The data analysis apparatus includes a data analysis unit that generates a reference for determining whether or not the medical robots are normal, based on the data transmitted from the medical robots. The data analysis unit monitors the data transmitted from each of the medical robots in operation based on the reference.
The present invention provides an image analysis method for generating data indicating a region of a cell nucleus in an image of a tissue or a cell. The image analysis method is a method for analyzing an image of a tissue or a cell using a deep learning algorithm of a neural network structure, and generates data indicating a region of a cell nucleus in an analysis target image by the deep learning algorithm by generating analysis data from the analysis target image including an analysis target tissue or cell, and inputting the analysis data in the deep learning algorithm.
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 10/56 - Extraction of image or video features relating to colour
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G06T 7/90 - Determination of colour characteristics
Disclosed is a surgical image providing method using a surgical robot for providing an image of a surgery performed by the surgical robot, the surgical robot including an arm device to which a surgical instrument is attached, and an operation device that an operator operates to drive the arm device. The method includes: obtaining a state log indicating a state of an operation target of the operation device, the state being changed according to an operation of the operator to the operation target; generating a reconstructed image visualizing the operation of the operator to the operation target, on the basis of the state log; and providing a surgical image in which a motion image showing a motion of the surgical robot or the surgical instrument is associated with the reconstructed image.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
13.
LABELED POLYPEPTIDE, MODIFIED POLYPEPTIDE, PRODUCTION METHOD FOR THESE POLYPEPTIDES, REAGENT CONTAINING THESE POLYPEPTIDES, AND MEASUREMENT METHOD FOR TARGET SUBSTANCE
Disclosed is a labeled polypeptide that includes a glutamine residue having a side chain represented by formula (I) below:
Disclosed is a labeled polypeptide that includes a glutamine residue having a side chain represented by formula (I) below:
(wherein, (C) represents an α-carbon of the glutamine residue, X represents a straight chain alkylene group, Y represents a polyethylene glycol chain, Z represents a label, L represents a spacer or an atomic bond, and the polyethylene glycol chain has a molecular weight of 1100 or larger).
G01N 33/532 - Production of labelled immunochemicals
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
14.
CONTROL METHOD FOR TEST SYSTEM, CONTROL METHOD FOR SMEAR PREPARATION DEVICE, TEST SYSTEM, AND SMEAR PREPARATION DEVICE
Disclosed is a control method for a test system including a smear imaging unit configured to image a smear of a specimen, the control method including: preparing a plurality of the smears; sequentially storing, in a storing container capable of storing therein a plurality of the smears, the smears having been prepared; and transporting, when information about a standby situation for imaging processing by the smear imaging unit satisfies a predetermined condition, the storing container that stores therein the smears to the smear imaging unit regardless of the number of the smears stored in the storing container.
Diagnostic apparatus and instruments for medical or veterinary purposes; Medical apparatus for performing in-vitro diagnostic tests; Clinical laboratory analyzers for medical purposes; Urine analyzers for medical diagnostic uses; Urine cell analyzing apparatus and instruments; Medical diagnostic analyzers for measuring, testing or analyzing urine and other bodily fluids; Urine sediment analyzers; Bacteria analyzing apparatus and instruments, for medical use; Flow cytometers for testing or analyzing urine and other bodily fluids; Urine particle digital image analyzers; Urine particle imaging device; Urine chemistry analyzers; Analyzers used for urine qualitative test; Sample preparation device for medical diagnostic uses; Sample transfer apparatus; Laboratory automation system used for urine tests; Clinical laboratory analyzers installed with the programs for controlling clinical test workflow; Parts and fittings for all the aforementioned goods.
Urine analyzers for medical diagnostic uses; Urine cell analyzing apparatus and instruments; Medical diagnostic analyzers for testing or analyzing urine and other bodily fluids; Urine particle digital image analyzers; Urine particle imaging device; Parts and fittings for all the aforementioned goods.
Urine analyzers for medical diagnostic uses; Urine cell analyzing apparatus and instruments; Medical diagnostic analyzers for testing or analyzing urine and other bodily fluids; Urine particle digital image analyzers for medical use; Urine particle imaging device for medical use; Parts and fittings for all the aforementioned goods.
Diagnostic apparatus and instruments for medical or veterinary purposes; Medical apparatus for performing in-vitro diagnostic tests; Clinical laboratory analyzers for medical purposes; Urine analyzers for medical diagnostic uses; Urine cell analyzing apparatus and instruments; Medical diagnostic analyzers for measuring, testing or analyzing urine and other bodily fluids; Urine sediment analyzers; Bacteria analyzing apparatus and instruments, for medical use; Flow cytometers for testing or analyzing urine and other bodily fluids; Parts and fittings for all the aforementioned goods.
Medical or veterinary diagnostic apparatus and instruments for urine analysis; medical apparatus for performing in-vitro diagnostic tests; clinical laboratory analyzers for medical purposes; urine analyzers for medical diagnostic uses; urine cell analyzing apparatus and instruments; medical diagnostic analyzers for measuring, testing or analyzing urine and other bodily fluids; urine sediment analyzers for medical purposes; bacteria analyzing apparatus and instruments, for medical use; flow cytometers for testing or analyzing urine and other bodily fluids; parts and fittings for all the aforementioned goods
A sample measuring apparatus according to one or more embodiments may include a measuring unit that measures a sample in a container, a power supply that supplies power to the measuring unit, and an apparatus housing that accommodates the measuring unit and the power supply inside. In one or more embodiments, the power supply may be arranged in an area in the apparatus housing, the area that is the power supply is arranged is different from an area that the measuring unit is arranged in a plan view, and the power supply is arranged at a higher position than a position that the measuring unit is arranged.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
21.
SAMPLE MEASURING APPARATUS AND SAMPLE MEASURING METHOD
A sample measuring apparatus according to one or more embodiments is disclosed, which is provided with a reagent container storage, in which a reagent container with a reagent is accommodated, and a measuring unit that measures a sample using a reagent. The reagent container storage has a housing, in which the reagent container is accommodated, and a cooling section that cools the housing. A ventilation passage is provided below a reagent container rack in the housing, and at least a part of the cooling section is provided at a higher part of the housing than the ventilation passage.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
22.
MANAGEMENT METHOD, INFORMATION PROCESSING APPARATUS, INFORMATION MANAGEMENT SYSTEM, AND BLOOD ANALYZER
Disclosed is a method for managing information on a blood product with a computer, including: obtaining a measurement result of a specimen, collected from the blood product, which is measured by a blood analyzer with product identification information of the blood product being used as specimen identification information of the specimen, and the specimen identification information; and in a database in which information on the blood product is stored in association with the product identification information, associating the measurement result with other information on the blood product other than the measurement result, on the basis of the product identification information used as the specimen identification information.
Disclosed is a transport method to be performed in an analysis system configured to transport a specimen to an analyzer configured to analyze an analyte contained in the specimen, the transport method comprising: cooling and preserving, in a cooling-and-preserving part, a quality control specimen containing an analyte having a known concentration; and controlling transport of the quality control specimen between the cooling-and-preserving part and the analyzer on the basis of a status of the analyzer.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
24.
METHOD FOR OBTAINING INFORMATION ON VON WILLEBRAND FACTOR, MEASUREMENT SAMPLE PREPARATION METHOD, AND REAGENT KIT
National University Corporation Hokkaido University (Japan)
SYSMEX CORPORATION (Japan)
Inventor
Kinjo, Masataka
Ganguly, Akshay
Ramaswamy, Lausonia
Abstract
Disclosed is a method for obtaining information on von Willebrand factor (VWF), comprising the following steps: denaturing, with urea, VWF contained in a biological sample; fluorescently labeling the denatured VWF using a capturing agent that comprises a fluorescent substance and binds to the denatured VWF; and obtaining information on the size of the fluorescently-labeled VWF by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy.
Disclosed is a specimen rack transport device comprising: a transport mechanism configured to transport, on a placement surface, a specimen rack holding a specimen container; a flow path member configured to receive a specimen spilled from the specimen container onto the placement surface and cause the specimen to flow through the flow path member; and a collecting container configured to collect the specimen having flowed through the flow path member.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
26.
METHOD FOR CLASSIFYING WHITE BLOOD CELLS INTO SUBPOPULATIONS
Disclosed is a method for classifying white blood cells into subpopulations, comprising: preparing a measurement sample by mixing a specimen containing white blood cells, a hemolysis reagent containing a surfactant, a first fluorescent dye, and a second fluorescent dye; irradiating particles in the measurement sample with light, and detecting optical information including first fluorescence information based on fluorescence from the first fluorescent dye, second fluorescence information based on fluorescence from the second fluorescent dye, and scattered light information; sorting a cell population containing basophils from particles in the measurement sample based on optical information including the first fluorescence information; classifying white blood cells contained in the cell population into subpopulations based on the second fluorescence information and the scattered light information; and counting cells classified as a population of basophils in the subpopulation; wherein the second fluorescent dye is a fluorescent dye having maximum absorption in a wavelength range different from that of the first fluorescent dye.
Disclosed is a specimen analyzer configured to analyze an analyte in a specimen, the specimen analyzer including: a measurement unit including an optical detection part configured to obtain an optical signal from the specimen; and an analysis unit configured to analyze first data and second data that correspond to the optical signal, wherein the analysis unit executes, on the first data, a first analysis operation according to an artificial intelligence algorithm, and executes a second analysis operation of processing a representative value, of the second data, that corresponds to a feature of the analyte.
A specimen analysis system includes: a measurement data acquisition unit that acquires measurement data of particles obtained from a flow cytometer measuring the particles contained in a measurement specimen prepared by adding a reagent to a sample; an output mode information acquisition unit that acquires output mode information indicating an output form of the measurement data; and an output unit configured to output the measurement data in the output form in accordance with the output mode information.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
29.
SPECIMEN ANALYSIS CARTRIDGE AND MANUFACTURING METHOD FOR THE SAME
Disclosed is a specimen analysis cartridge that includes: a first base having a micro flow path formed in at least one surface; a second base disposed so as to oppose a surface at which the micro flow path of the first base is formed; and a photocurable resin layer for adhering the first base and the second base to each other, and the first base and the second base each contain at least one of cycloolefin polymer and cycloolefin copolymer.
Disclosed is a specimen analyzer for analyzing an analyte in a specimen, the specimen analyzer including: a measurement unit including a plurality of first sample preparation parts each configured to prepare a first measurement sample on the basis of the specimen and a first reagent, a second sample preparation part configured to prepare a second measurement sample on the basis of the specimen and a second reagent, and an optical detection part configured to obtain a first optical signal from the first measurement sample and obtain a second optical signal from the second measurement sample; and an analysis unit configured to analyze first data that corresponds to the first optical signal and second data that corresponds to the second optical signal, wherein the analysis unit executes analysis of a first measurement item with respect to the first measurement sample, through a first analysis operation of processing the first data according to an artificial intelligence algorithm, executes analysis of a second measurement item with respect to the first measurement sample, through at least one of the first analysis operation and a second analysis operation of processing a first representative value, of the first data, that corresponds to a feature of the analyte, and executes analysis with respect to the second measurement sample, through a third analysis operation of processing a second representative value, of the second data, that corresponds to a feature of the analyte.
Provided is a cell analysis method and a cell analyzer that, in a configuration in which data obtained from a plurality of cells contained in a specimen is analyzed, can process, at a requested throughput, data of cells having a significantly increased information amount. The cell analysis method, using a cell analyzer that comprises a host processor and a parallel-processing processor, includes: obtaining, on the basis of control by the host processor, data regarding each of a plurality of cells in a specimen; executing, by the parallel-processing processor, parallel processing regarding the data; and generating, on the basis of a result of the parallel processing, information regarding a cell type with respect to each of the plurality of cells.
Disclosed is a test soil comprising a plurality of molecules of labeled polypeptides, wherein the labeled polypeptide is a polypeptide to which a dye is added by a covalent bond, and the value of X calculated by the following formula is 100,000 or more:
Disclosed is a test soil comprising a plurality of molecules of labeled polypeptides, wherein the labeled polypeptide is a polypeptide to which a dye is added by a covalent bond, and the value of X calculated by the following formula is 100,000 or more:
X =
Number of dyes comprised in one molecule of labeled polyeptide
×
Molar absorption coefficient of dye
M
-1
cm
-1
.
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
A61B 90/70 - Cleaning devices specially adapted for surgical instruments
33.
WOUND TREATMENT DEVICE AND WOUND COVERING USED THEREIN
The present invention provides a wound treatment device with which there is no increase in infection or delay in healing due to, inter alia, an irrigation liquid leakage or foam adjustment, embedment, or replacement, and that can effectively protect the surroundings of a wound and can be easily handled without requiring skill. The present invention also provides a wound covering used therein. The present invention provides a wound treatment device characterized by comprising a wound covering constituted from a flexible laminate including a porous member and a watertight film member laminated on the porous member, a negative pressure supply pump for supplying negative pressure to the porous member side, an irrigation fluid pump for supplying an irrigation fluid to the porous member side and discharging the irrigation fluid from the porous member side, a canister for intaking the discharged irrigation fluid, and a control unit for controlling the negative pressure supply pump and the irrigation fluid pump, the wound treatment device performing negative pressure wound therapy and irrigation on the wound covered on the porous member side by the wound covering.
A control method of controlling a computer to analyze, at a second facility, nucleic acid sequence data obtained, at a first facility, by a sequencer that reads a nucleic acid sequence, for a gene panel test, comprising receiving, from the first facility via a network, a sequence data set comprising a plurality of nucleic acid sequence data obtained by the sequencer corresponding to each of a plurality of library samples comprising a first library sample and a second library sample, which are prepared from a specimen of a subject, and link information indicating that the first library sample and the second library sample are prepared from the specimen of the same subject; analyzing a first sequence data and a second sequence data corresponding to each of the first library sample and the second library sample linked by the link information; and outputting analysis information based on an analysis result of the first sequence data and an analysis result of the second sequence data, is disclosed.
Disclosed is a measurement apparatus for analyzing a cell contained in a specimen, comprising: a chamber for preparing a measurement sample in which the cell is stained with first and second fluorescent dyes contained in a reagent supplied from at least one reagent container; a liquid feeding section for feeding the reagent from the reagent container to the chamber via a liquid feeding tube provided between the reagent container and the chamber; and a detection section that acquires first and second signals each corresponding to fluorescence of a first wavelength and fluorescence of a second wavelength emitted from the cell stained with the first and second fluorescent dyes in response to irradiation of the measurement sample flowing in a flow cell with light; and an analysis section that analyzes the cell on the basis of the first and second signals.
A method of quality control of a specimen prepared from a sample according to an embodiment may include: setting, from a control index information (MII) in which a plurality of indexes for the specimen are respectively associated with control values corresponding to the plurality of indexes, at least one index to be used for quality control of the specimen; obtaining a feature value relating to the at least one index from image data of the specimen; and outputting quality control information of the specimen based on the feature value and a control value associated with the at least one index.
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
Disclosed is a polypeptide belonging to the avidin-streptavidin family, wherein the polypeptide comprises a D-amino acid residue in 90% or more of amino acid residues among amino acid residues other than glycine of the polypeptide, has a binding ability to L-biotin, and has substantially no binding ability to D-biotin.
A method of generating smear quality control information according to an embodiment may include: obtaining a plurality of image data from a plurality of smears, respectively; obtaining, from the plurality of image data, feature values each of which reflects a staining state of each smear; and generating quality control information based on the feature values.
G06T 7/90 - Determination of colour characteristics
39.
REAGENT FOR MEASURING L-BIOTIN, METHOD FOR MEASURING SAMPLE CONTAINING L-BIOTIN, METHOD FOR DETERMINING NUMBER OF LABELS OF L-BIOTIN-LABELED SUBSTANCE, AND METHOD FOR PRODUCING SOLID PHASE ON WHICH OPTICALLY ISOMERIC BIOTIN-BINDING SITE IS IMMOBILIZED
Disclosed is a reagent for measuring L-biotin, comprising an optically isomeric biotin-binding site and an azobenzene derivative represented by following formula (I):
Disclosed is a reagent for measuring L-biotin, comprising an optically isomeric biotin-binding site and an azobenzene derivative represented by following formula (I):
wherein R1 to R10 are each independently a group selected from the group consisting of a hydrogen atom, a hydroxy group, a carboxy group, C1 to C6 dialkylamino groups having no substituent or a substituted group, C1 to C6 alkyl groups having no substituent or a substituted group, and C1 to C6 alkoxy groups having no substituent or a substituted group, provided that at least one of R1 to R5 is a hydroxy group or a C1 to C6 dialkylamino group having no substituent or a substituted group, and at least one of R6 to R10 is a carboxy group.
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
G01N 33/82 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
C07C 245/08 - Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
40.
CARTRIDGE AND METHOD OF ANALYSING A BIOLOGICAL SAMPLE
A cartridge comprises a chip chamber configured to house a microfluidic chip comprising a plurality of sets of cell channels configured to capture cells from a biological sample. The cartridge also comprises a sample chamber configured to receive the biological sample and be in fluid connection with the plurality of sets of cell channels and a plurality of medium reservoirs. Each medium reservoir of the plurality of medium reservoirs is configured to be in fluid connection with a respective set of cell channels of the plurality of sets of cell channels. The cartridge further comprises culture medium source in fluid connection with the plurality of medium reservoirs and configured to supply a culture medium to the plurality of medium reservoirs.
A sample analyzer includes a suction unit configured to suction a sample in a sample container through a stopper installed in an opening of the sample container; a rack transport unit configured to transport a sample rack holding a sample container along a transport path, and position the sample container held by the sample rack at a suction position by the suction unit; a sample transport unit in which a sample container other than the sample container transported by the rack transport unit is installed and which is configured to transport the installed sample container to the suction position provided on the transport path; a measurement unit configured to measure a sample suctioned by the suction unit from the sample container positioned at the suction position; and an analysis unit configured to analyze the sample based on the measurement result of the measurement unit.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
42.
METHOD FOR APPLYING CONTROL REFERENCE VALUE TO SPECIMEN ANALYZER, SPECIMEN ANALYZER,
AND COMPUTER PROGRAM
Disclosed is a method for applying a control reference value regarding a quality control sample to a specimen analyzer by a computer, the method comprising: generating the control reference value on the basis of a measurement result of the quality control sample measured by the specimen analyzer; and applying the control reference value to the specimen analyzer.
G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control (DNC), flexible manufacturing systems (FMS), integrated manufacturing systems (IMS), computer integrated manufacturing (CIM)
43.
REFERENCE ELECTRODE, ELECTRODE, AND SENSOR INCLUDING THESE
Disclosed is a reference electrode comprising: an ionic-liquid-containing membrane; and a hydrophilic membrane disposed on the ionic-liquid-containing membrane.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemical reagents other than for medical or veterinary purposes; Chemical preparations for use in scientific and research purposes; Laboratory diagnostic chemicals for immunoassay analysis; Diagnostic reagents other than for medical or veterinary purposes; Diagnostic preparations other than for medical or veterinary purposes; Testing reagents and preparations used in blood testing for scientific or research purposes; Reagents for immunoassay analysis for scientific or research purposes; Reagents for clinical chemistry testing for scientific or research purposes; Chemical agents, namely, reference control materials for industrial use; Chemical agents, namely, chemical reference materials for industrial use; Chemical agents, namely, quality control standard solutions and quality control materials for industrial use for testing and calibrating medical apparatus and reagents; Detergents for industrial use; Cleaning solutions for industrial use; Cleaning preparations for industrial use Detergents for medical instruments use; Cleaning solutions for medical instruments use; Cleaning preparations; Cleaning solutions for diagnostic and testing apparatus; Cleaning preparations for apparatus and instruments Diagnostic reagents and diagnostic preparations for medical or veterinary purposes; Chemical reagents and chemical preparations for medical or veterinary purposes; Chemical reagents and chemical preparations for pharmaceutical purposes; Medical diagnostic reagents for immunoassay analysis; Medical diagnostic reagents for blood analysis; Medical diagnostic reagents for clinical chemistry testing; Reference control materials for medical use; Chemical reference materials for medical use; Medical diagnostic preparations, namely, quality control standard solutions and quality control reagents for testing and calibrating medical apparatus and reagents; Detergents for medical purposes; Cleaning solutions for medical purposes; Cleaning preparations for medical purposes Laboratory equipment other than for medical or veterinary purposes; Measuring apparatus for scientific or research purposes; Cuvette for scientific, research or laboratory purposes; Pipettes for scientific, research or laboratory purposes; Disposable pipette tips for scientific, research or laboratory purposes; Plastic cups for scientific, research or laboratory purposes; Test tubes for scientific, research or laboratory purposes; Computer programs for use in the field of medical, clinical, diagnostic or laboratory analysis; Application software for use in the field of medical, clinical, diagnostic or laboratory analysis Medical diagnostic apparatus and instruments for blood analysis; Medical diagnostic apparatus and instruments for the pretreatment of blood; Medical diagnostic apparatus and instruments for immunochemical analysis; Medical diagnostic apparatus and instruments for immunological testing; Medical diagnostic apparatus and instruments for immunoassay; Medical diagnostic apparatus and instruments for clinical chemistry analysis; Medical diagnostic apparatus and instruments, namely, blood diluting devices, pipettes, sample containers for in vitro diagnosis, medical sample bottles, and test tube stands
45.
URINE SPECIMEN ANALYSIS METHOD AND URINE SPECIMEN ANALYZER
Disclosed is a urine specimen analysis method for obtaining information about a urine particle in a urine specimen, and the urine specimen analysis method includes: obtaining count information about the number of Trichomonas vaginalis cells and first information including count information about at least one of the number of squamous epithelium cells and the number of white blood cells, based on detection data of the urine particle in the urine specimen; and outputting information about suspicion of Trichomonas infection based on at least the count information about the number of Trichomonas vaginalis cells, and the first information.
Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 74th, 76th and 77th amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
47.
METHOD AND SYSTEM FOR PERFORMING QUALITY CONTROL ON A DIAGNOSTIC ANALYZER
A method for performing quality control on a diagnostic analyzer includes receiving control measurement values from each of a plurality of diagnostic analyzers. A quality control measurement value is received from a target diagnostic analyzer. The quality control measurement value is compared with statistical criteria associated with the plurality of quality control measurement values received from the plurality of diagnostic analyzers. A comparison result is communicated to a user interface associated with the target diagnostic analyzer.
G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control (DNC), flexible manufacturing systems (FMS), integrated manufacturing systems (IMS), computer integrated manufacturing (CIM)
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
Automation of analysis of cells contained in different types of specimens collected from different organs or sites is enabled. This sample preparation method is a method for preparing a sample for analyzing cells contained in a specimen, and includes: obtaining a dispersion condition corresponding to the type of the specimen; and dispersing the cells aggregated and contained in the specimen, according to the obtained dispersion condition.
A sample testing system comprising: a transporting apparatus; a testing apparatus for obtain a sample and performing testing on the obtained sample; and a controller. The controller executes operation of: controlling the transporting apparatus so as to transport the sample rack in first direction, such that each sample container held in a sample rack is transported to a obtaining position on which the testing apparatus obtains a sample and then the sample rack is transported toward the second position; changing, when retesting of a sample contained in a sample container is necessary, the transporting direction from the first direction to second direction, and then controlling the transporting apparatus so as to transport the sample container accommodating the sample, for which retesting is necessary, to the obtaining position again. Sample testing method and a computer program product are also disclosed.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
50.
COMPOUND OR SALT THEREOF, COMPOSITION, CHEMILUMINESCENCE METHOD, METHOD FOR MEASURING CHEMILUMINESCENCE SIGNAL, REAGENT, REAGENT KIT, AND METHOD FOR ASSAYING ANALYTE
Disclosed is a compound represented by formula [I] according to the specification, or a salt thereof, a composition comprising the compound, a chemiluminescence method using the compound, a method for measuring chemiluminescence signal, a reagent comprising the compound, a reagent kit comprising the compound and a method for assaying analyte.
C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
51.
CONTAINER TRANSFER METHOD AND CONTAINER TRANSFER APPARATUS
Disclosed is a container transfer method for transferring a container from a container holder capable of holding a plurality of containers, by using a holding section capable of performing an opening/closing operation, vertical movement, and horizontal movement. The method includes: moving the holding section downward to a position lower than a head portion of the container, at a position where the container is not held in a plan view; horizontally moving the holding section in an opened state, toward a target container on the container holder; after the horizontal movement of the holding section to the target container, closing the holding section with respect to the target container; and moving upward the holding section in a closed state.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
52.
SPECIMEN TRANSFER DEVICE AND SPECIMEN TESTING SYSTEM
Disclosed is a specimen transfer device connected to a rack transportation path of a specimen testing system, and the specimen transfer device includes: an ascending/descending mechanism configured to move a rack between a first ascending/descending position at which the rack in a first tier is disposed, and a second ascending/descending position at which the rack in a second tier is disposed; a container transfer mechanism configured to transfer a specimen container, to a second rack disposed in the second tier, from a first rack moved by the ascending/descending mechanism from the first ascending/descending position to the second ascending/descending position; a rack waiting region disposed in the first tier and configured to cause the rack to stay in a waiting state between the first ascending/descending position and a carrying-out position to the rack transportation path; and a first transportation mechanism configured to transport the first rack moved by the ascending/descending mechanism from the second ascending/descending position to the first ascending/descending position, through the rack waiting region, to the carrying-out position.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Disclosed is a specimen testing system that includes: a specimen rearrangement unit configured to transfer a specimen container held in a first rack to a second rack; a specimen processing unit configured to process a specimen in the specimen container held in the second rack; a specimen storage unit configured to transfer the specimen container having been processed by the specimen processing unit from the second rack to a specimen container storage instrument for storage; a transportation unit configured to transport the second rack among the specimen rearrangement unit, the specimen processing unit, and the specimen storage unit; and a transportation control unit programmed to control the transportation unit. The transportation control unit is programmed to control bidirectional transportation of the second rack between the specimen rearrangement unit and the specimen storage unit.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
54.
METHOD FOR IMPROVING AFFINITY OF ANTIBODY FOR ANTIGEN AND USE THEREOF
Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 77th, 79th and 81st amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
G01S 13/84 - Systems using reradiation of radio waves, e.g. secondary radar systems; Analogous systems wherein continuous-type signals are transmitted for distance determination by phase measurement
G01S 13/75 - Systems using reradiation of radio waves, e.g. secondary radar systems; Analogous systems using transponders powered from received waves, e.g. using passive transponders
G01S 13/32 - Systems for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated
G01S 13/76 - Systems using reradiation of radio waves, e.g. secondary radar systems; Analogous systems wherein pulse-type signals are transmitted
G01S 13/06 - Systems determining position data of a target
B61L 25/00 - Recording or indicating positions or identities of vehicles or vehicle trains or setting of track apparatus
B61L 27/00 - Central railway traffic control systems; Trackside control; Communication systems specially adapted therefor
G01S 11/06 - Systems for determining distance or velocity not using reflection or reradiation using radio waves using intensity measurements
G01S 13/60 - Velocity or trajectory determination systems; Sense-of-movement determination systems wherein the transmitter and receiver are mounted on the moving object, e.g. for determining ground speed, drift angle, ground track
55.
METHOD FOR IMPROVING AFFINITY OF ANTIBODY FOR ANTIGEN AND USE THEREOF
Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 18th, 20th and 22nd amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
56.
METHOD FOR IMPROVING AFFINITY OF ANTIBODY FOR ANTIGEN AND USE THEREOF
Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 17th, 18th and 20th amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
Diagnostic apparatus and instruments for medical or veterinary purposes; Medical apparatus for performing in-vitro diagnostic tests; Flow cytometers for medical diagnostic uses; Flow cytometers installed with the programs for controlling clinical test workflow; Flow cytometers and flow-based analyzers for analysis, detection, or counting of cells and particles for medical diagnostic uses; Clinical laboratory analyzers for diagnosis of blood diseases or monitoring immune system; Medical diagnostic analyzers for measuring, testing or analyzing blood; Blood testing apparatus; Apparatus for blood analysis; Sample preparation device for medical diagnostic uses; Sample autoloader for medical diagnostic uses; Sample transfer apparatus; Parts and fittings for all the aforementioned goods.
Medical or veterinary diagnostic apparatus and instruments for blood analysis, excluding in the field of genomics; Medical apparatus for performing in-vitro diagnostic tests, excluding for genetic tests; Flow cytometers for medical diagnostic uses, excluding for genetic analysis uses; Flow cytometers installed with the programs for controlling clinical test workflow; Flow cytometers and flow-based analyzers for analysis, detection, or counting of cells and particles for medical diagnostic uses; Clinical laboratory analyzers for diagnosis of blood diseases or monitoring immune system; Medical diagnostic analyzers for measuring, testing or analyzing blood, excluding genetic test analyzers; Blood testing apparatus for medical clinical uses, excluding genetic test analyzers; Apparatus for blood analysis for medical purposes, excluding for genomic analysis; Parts and fittings for all the aforementioned goods
In a configuration for analyzing data of cells measured by a cell measuring apparatus, accuracy of cell classification is improved without requiring the cell measuring apparatus to have high information processing capability. A cell analysis method, using a cell analyzer for analyzing cells in accordance with an artificial intelligence algorithm, includes: obtaining the data regarding the cells measured by the cell measuring apparatus; analyzing the data to generate information regarding a cell type of each of the cells; and transmitting the information to the cell measuring apparatus.
Disclosed is a method for producing an antibody, comprising culturing in a presence of a polyanionic compound an animal cell into which a gene encoding an antibody has been introduced whereby the animal cell produces the antibody, wherein the polyanionic compound is at least one selected from the group consisting of an anionic polysaccharide and an anionic polyamino acid, and the antibody is an antibody in which at least 3 amino acid residues of framework region 3 (FR3) are substituted each independently with an arginine residue or a lysine residue.
Disclosed is a specimen analysis method for analyzing a specimen regarding a plurality of measurement items, the specimen analysis method comprising: measuring a first measurement item and a second measurement item on the basis of a measurement order; executing a process related to a time difference between a measurement of the first measurement item and a measurement of the second measurement item; and obtaining a calculation value from a measurement value of the first measurement item and a measurement value of the second measurement item.
A sample measuring device reduces the frequency with which a user introduces a measurement aid into the sample measuring device is provided. A sample measuring method measures a sample using a container containing a measurement aid which is a solid. The sample measuring method includes loading a predetermined number of measurement aids into a container from a storage chamber in which a plurality of measurement aids are movably stored in a cartridge attached to a sample measuring device, dispensing the sample into the container, and measuring the sample in the container into which the measurement aid has been loaded.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
In a dispensing system, a body is arranged outside a specimen processing cabinet, and in a state where a hand and a dispenser are inserted into the specimen processing cabinets, a specimen accommodated in a specimen container held by the hand is dispensed into a dispensing container by the dispenser.
Disclosed is a method for detecting an antigen-specific activated T cell comprising: acquiring first information on a particle size and second information on a T cell activation marker for a first measurement sample prepared by mixing in vitro a first specimen separated from a biological sample containing a T cell and an antigen-presenting cell and an antigen reagent containing a predetermined antigen, by measuring the first measurement sample with a flow cytometer; acquiring the first information and the second information for a second measurement sample prepared from a second specimen separated from the biological sample and not containing the antigen reagent, by measuring the second measurement sample with the flow cytometer; detecting a target particle in the first measurement sample based on the first information and the second information on the first measurement sample, and detecting a background particle in the second measurement sample based on the first information and the second information on the second measurement sample; and detecting a cell complex in which the T cell and the antigen-presenting cell adhere to each other in the first measurement sample, the cell complex including a T cell activated by the predetermined antigen, based on a detection result of the target particle and a detection result of the background particle.
METHOD FOR MEASURING EXTRACELLULAR VESICLES, METHOD FOR ACQUIRING INFORMATION ON NEURODEGENERATION, METHOD FOR ISOLATING EXTRACELLULAR VESICLES AND REAGENT KITS
The present invention pertains to a method for measuring extracellular vesicles. The present invention pertains to a method for acquiring information on neurodegeneration. The present invention pertains to a method for isolating extracellular vesicles. The present invention pertains to reagent kits that are to be used in these methods.
Diagnostic apparatus and instruments for medical or veterinary purposes; Medical apparatus for performing in-vitro diagnostic tests; Clinical laboratory analyzers for medical purposes; Immunology analyzers for medical diagnostic uses; Immunoassay apparatus and instruments; Immunochemical analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; Blood testing apparatus; Apparatus for blood analysis; Sample preparation device for medical diagnostic uses; Sample transfer apparatus; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments; Pipettes for medical diagnostic uses; Disposable tips for medical diagnostic uses; Parts and fittings for all the aforementioned goods.
Medical or veterinary diagnostic apparatus and instruments for blood analysis; Medical apparatus for performing in-vitro diagnostic tests; Clinical laboratory analyzers for medical purposes; Immunology analyzers for medical diagnostic uses; Immunoassay apparatus and instruments; Immunochemical analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood; Blood testing apparatus; Apparatus for blood analysis for medical purposes; Sample preparation device for medical diagnostic uses; Sample transfer apparatus for medical diagnostic uses; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments for medical diagnostic uses; Pipettes for medical diagnostic uses; Disposable tips for medical diagnostic uses; Parts and fittings for all the aforementioned goods
Medical or veterinary diagnostic apparatus and instruments for blood analysis; Medical apparatus for performing in-vitro diagnostic tests; Clinical laboratory analyzers for medical purposes; Immunology analyzers for medical diagnostic uses; Immunoassay apparatus and instruments; Immunochemical analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood; Blood testing apparatus; Apparatus for blood analysis for medical purposes; Sample preparation device for medical diagnostic uses; Sample transfer apparatus for medical diagnostic uses; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments for medical diagnostic uses; Pipettes for medical diagnostic uses; Disposable tips for medical diagnostic uses; Parts and fittings for all the aforementioned goods
69.
METHOD OF REMOTELY SUPPORTING SURGERY ASSISTANT ROBOT AND REMOTE SUPPORT SYSTEM
A method for remotely supporting a surgery assistant robot may include: receiving at least one piece of operation information concerning an operation of the surgery assistant robot, by a server device that performs a remote support for the surgery assistant robot; and transmitting, in response to a predetermined event, at least one of a sound, an image, or a text from the server device to at least one of the surgery assistant robot or a terminal device.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 5th, 9th and 22nd amino acid residues of a light chain defined by Kabat method to charged amino acid residues.
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
71.
REPORT GENERATING METHOD OF GENERATING A REPORT REPORTING A LEVEL OF PATHOGENICITY OF A GENETIC MUTATION, AND A REPORT GENERATING DEVICE
A report generating method generates a report for reporting a level of pathogenicity of a genetic mutation. The report generating method obtains information on a genetic mutation detected in a gene panel test, generates an evaluation result for a plurality of evaluation items based on a first criterion for evaluating each of the evaluation items and at least information on the genetic mutation, determines the level of pathogenicity based on a second criterion for determining the level of pathogenicity and the evaluation result, determines an undetermined item for which the evaluation result is undetermined among the plurality of evaluation items, determines whether the level of pathogenicity is tentative based on a determination result of the undetermined item, and generates a report for reporting the level of pathogenicity according to the determination result of whether the level of pathogenicity is tentative.
A quality control sample measurement method, a sample analysis device and a supply device capable of normally acquiring a measurement result of a quality control sample are provided. The quality control sample measurement method for measuring a quality control sample stored in a cold state includes a step of stirring the quality control sample in a first operation mode (step S2) and a step of measuring the stirred quality control samples (step S3). The stirring in the first operation mode differs from the stirring in the second operation mode for stirring the subject sample collected from the subject.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
Medical or veterinary diagnostic apparatus and instruments for blood analysis; Hematology analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; Blood testing apparatus; Apparatus for blood analysis for medical purposes; Blood cell analyzers for medical purposes; Cell counters, namely, apparatus for counting, analyzing or identifying cells in blood or bodily fluids; Blood cell counters; Measuring apparatus and instruments for analyzing bodily fluids for medical purposes; Smear test sample making apparatus and instruments for medical diagnostic uses; Sample preparation device for medical diagnostic uses; Sample transfer apparatus for medical diagnostic uses; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments for medical diagnostic uses; Parts and fittings for all the aforementioned goods
Diagnostic apparatus and instruments for medical or veterinary purposes; Hematology analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; Blood testing apparatus; Apparatus for blood analysis; Blood cell analyzers; Cell counters; Blood cell counters; Bodily fluids measuring apparatus and instruments; Smear test sample making apparatus and instruments; Sample preparation device for medical diagnostic uses; Sample transfer apparatus; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments; Parts and fittings for all the aforementioned goods.
75.
METHOD AND REAGENT KIT FOR ASSISTING DETERMINATION OF LUNG CANCER PROGNOSIS
The present invention pertains to a method for assisting the determination of lung cancer prognosis, said method comprising measuring miR-21C in a measurement sample prepared from a specimen of a lung cancer patient, wherein the expression level of miR-21C obtained by the measurement serves as an indicator of the lung cancer prognosis. The present invention also pertains to a reagent kit to be used in this method.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
The present invention is a sample processing apparatus. The apparatus includes: a sample processing unit configured to process a sample; a display; a memory for storing an electronic manual for the sample processing apparatus; and a controller that is capable of showing a relevant part of the electronic manual on the display when a trouble has occurred in the sample processing unit, the relevant part of the electronic manual describing an operation procedure to deal with the trouble.
An imaging method for capturing an image of a sample in a microscope system comprises: a step (step S4) for, on the basis of a plurality of captured images obtained by capturing images of the sample while changing the relative position of the focus of a light receiving optical system to the sample, determining a plurality of relative positions that serve as candidates; a step (step S6) for determining a relative position for performing imaging from among the plurality of relative positions that serve as the candidates; and a step (step S10) for performing imaging on the sample at the determined relative position.
A method for analyzing a cause of prolonging coagulation time of a blood specimen includes: adding a calcium solution to a first sample resulting from a first waiting time from mixing of a blood specimen from a subject and a measurement reagent for an activated partial thromboplastin time; obtaining a first coagulation time and/or a first parameter regarding a differential of a coagulation waveform, for the first sample; adding the calcium solution to a second sample resulting from a second waiting time, which is longer than the first waiting time, from mixing of the blood specimen from the subject and the measurement reagent; obtaining a second coagulation time and/or a second parameter regarding a differential of a coagulation waveform, for the second sample; and obtaining information regarding a cause of prolonging a coagulation time, on the basis of the first and second coagulation time and/or the first and second parameter.
A blood analyzer according to one or more embodiments may include: a specimen preparation part that prepares a measurement specimen by mixing a reagent into a blood preparation; a measurement part that measures the measurement specimen; a measurement mode selection unit that receives an input of a type of blood preparation as a measurement target selected from a plurality of types of blood preparations; and a controller. The controller may cause the specimen preparation part to prepare the measurement specimen depending on the selected type of blood preparation.
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
80.
METHOD FOR IMPROVING AFFINITY OF ANTI-CYTOKINE ANTIBODY FOR ANTIGEN, METHOD FOR PRODUCING ANTI-CYTOKINE ANTIBODY, AND ANTI-CYTOKINE ANTIBODY
Disclosed is a method for improving an affinity of an anti-cytokine antibody for an antigen, the method comprising: in an anti-cytokine antibody whose electrical characteristic of a complementarity determining region (CDR) is negatively charged, changing at least 3 amino acid residues of light chain framework region 3 to arginine residues or lysine residues, thereby improving an affinity for an antigen as compared with that of an antibody before the at least 3 amino acid residues are changed to arginine residues or lysine residues, wherein the at least 3 amino acid residues comprise residues at least 3 positions selected from the group consisting of positions 63, 65, 67, 70 and 72 of a light chain defined by Chothia method.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY (Japan)
Inventor
Kojima, Junko
Uchiyama, Kenichi
Yoshida, Yumi
Abstract
The ion sensor of the present invention is a current measurement type ion sensor that measures a current to measure a target ion, and includes an organic phase retaining layer containing an organic phase capable of forming an interface with the sample containing the target ion, a first electrode to which the organic phase retaining layer is laminated and containing a first insertion material composed of an inorganic compound, a second electrode arranged so as to face the organic phase holding layer and in contact with the sample.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagent paper, other than for medical or veterinary purposes; reagents and preparations for testing biological samples, beverage and water other than for medical or veterinary use; chemical reference materials in the nature of calibrating solutions, having known concentration or properties to be analyzed for validating the test results of analyzers for scientific or research use; quality control materials, namely stabilized blood with chemicals used for verifying test results of scientific or laboratory apparatus; diagnostic reagents for genetic tests other than for medical or veterinary use; diagnostic reagents for cell analysis tests other than for medical or veterinary use; diagnostic reagents for protein analysis tests other than for medical or veterinary use; biological and biotechnological preparations for use in cell cultures, other than for medical or veterinary purposes Reagent paper for medical purposes; diagnostic reagents and diagnostic preparations for medical or veterinary use; testing reagents and preparations for testing biological samples for medical or veterinary use; quality control materials, namely stabilized blood with chemicals used for verifying test results of medical or veterinary apparatus; cleaning preparations for medical or veterinary use, namely, detergents for removing residues of biological sample or reagents remained in medical or veterinary apparatus; reagents for genetic testing for medical or veterinary purposes; reagents for cell analysis testing for medical or clinical use; reagents for protein analysis testing for medical or clinical use; biological preparations for medical purposes, namely, biological preparations for the treatment of cancer or blood diseases; cell preparations for treatment of diseases or disorders, namely, stem cells for medical purposes downloadable electronic publications, namely, book and magazine featuring medical, clinical, scientific, diagnostic or research analysis techniques; laboratory apparatus and instruments for detecting, counting or analyzing cells or particles for research, scientific or industrial uses; testing apparatus and instruments for detecting, testing or analyzing microorganism for scientific, research or laboratory use; research laboratory analyzers for measuring, testing and analyzing blood or other body fluids; laboratory instruments and equipment, namely, flow cytometers for scientific or laboratory use; particle analyzers for scientific, research or laboratory use; particle counters for scientific, research or laboratory use; test tubes for scientific, research or laboratory use; pipette tips for scientific, research or laboratory use; computers; downloadable computer program for use in the field of medical, clinical, diagnostic or laboratory analysis; genetic testing apparatus for scientific, research or laboratory use medical apparatus and instruments, namely apparatus for testing biological samples; in vitro diagnostic apparatus and instruments for medical use, namely, hematology, hemostasis, urine, immunology or genetic analyzers; measurement apparatus and instruments for counting or measuring cells in biological samples; flow cytometers for medical or clinical diagnostic use; particle analyzers for medical or clinical use; particle counters for medical or clinical use; in-vitro diagnostic sample container for medical purposes; blood testing apparatus; surgical apparatus and instruments; surgical robots, and machines and instruments therefor, namely, surgical robots, rehabilitation robots, manipulators for medical or veterinary robots or knives for surgical purposes or scalpels; gloves for medical purposes; dropping pipettes for medical analysis; containers for medical purposes, namely, sampling bottles sold empty for medical analysis; container for medical purposes, namely, disposable beakers for medical analysis; genetic testing apparatus and instruments for medical or clinical use; cell analysis apparatus and instruments for medical or clinical use, namely, blood or urine cell analyzer; protein analysis apparatus and instruments namely, apparatus detecting specified protein in blood or bodily fluids, or measuring its quantity for medical or clinical use Installation, repair and maintenance of computers and computer peripheral equipment; providing information relating to installation, repair and maintenance of computers and computer peripheral equipment; installation, repair and maintenance of medical apparatus and instruments; providing information relating to installation, repair and maintenance of medical apparatus and instruments; installation, repair and maintenance of medical or veterinary robots and their parts and accessories; repair and maintenance of medical or veterinary robots and their parts and accessories by remote operation; providing information relating to installation, repair and maintenance of medical or veterinary robots and their parts and accessories; installation, repair and maintenance of measuring and testing apparatus and instruments; providing information relating to installation, repair and maintenance of measuring and testing apparatus and instruments; installation, repair and maintenance of data processing apparatus and instruments; providing information relating to installation, repair and maintenance of data processing apparatus and instruments; installation, repair and maintenance of electronic machines, apparatus and their parts; providing information relating to installation, repair and maintenance of electronic machines, apparatus and their parts; installation, repair and maintenance of scientific apparatus and instruments; providing information relating to installation, repair and maintenance of scientific apparatus and instruments electronic storage services for archiving electronic data; providing information on electronic storage services for archiving electronic data; maintenance of computer programs for internet servers; providing temporary use of non-downloadable computer programs in the field of medical, clinical, or laboratory analysis and diagnosis; providing scientific and technological information in the field of scientific research via computer terminal communications and the Internet; providing scientific and technological information in the field of scientific research via network communication; scientific testing, inspection, or research on pharmaceuticals and providing information thereof; scientific and technological services, namely, collection, analysis, evaluation, and scientific research on clinical test data measured by medical apparatus, and providing information thereof; scientific and technological services, namely, testing, inspection, measurement, analysis, evaluation and scientific research on medical apparatus and providing information thereof; remote monitoring by computer system for repair or maintenance of medical apparatus and instruments; remote monitoring of surgical apparatus and instruments by computer network; remote monitoring by computer system for repair or maintenance of surgical apparatus and instruments; scientific and technological services, namely, testing, inspection, measurement, analysis, evaluation, or research on test reagents, and provision of information thereof; remote monitoring by computer system for repair or maintenance of measuring or testing apparatus and instruments; remote monitoring by computer system for repair or maintenance of electronic machines, apparatus and their parts; electronic storage services for archiving electronic data on computer terminals; remote monitoring by computer system for repair or maintenance of scientific apparatus and instruments; rental of measuring or testing apparatus and instruments; rental of computers; rental of scientific apparatus and instruments, namely, laboratory apparatus, measuring apparatus; online remote monitoring by computer system for repair or maintenance of computers and computer peripherals; scientific testing and research relating to protein analysis for scientific research purposes; scientific testing and research relating to genetic analysis for research purposes; scientific research in the field of genetics and genetic engineering; online remote monitoring by computer system for repair or maintenance of data processing apparatus and instruments; scientific testing services to detect and quantify gene mutations, gene variations, gene amplification, gene loss and gene fusion; scientific testing, inspections, or research on pharmaceuticals, and providing information thereof; consultation and advice on the design, development, and maintenance of computer software for medical, veterinary, clinical testing, clinical diagnosis, or research purposes; rental of electronic storage of data in the medical, clinical, and scientific analysis and diagnostic fields; hosting of websites of others on the Internet in the fields of medical, clinical, scientific analysis and diagnostics; gathering of the quality control data and log data collected from customers medical apparatus, and processing and storing its data in the server in the field of medical, clinical or laboratory analysis; medical research; scientific and technological services, namely, testing, inspection, measuring, analysis, evaluation and scientific research on diseases or disorders for medical purposes and providing information thereof; electronic storage of medical records; design, development, programming, installation, implementation, maintenance and updating of computer software in the field of medical diagnostics; providing temporary use of online non-downloadable computer programs for education management in the field of healthcare; online remote monitoring by computer system for repair or maintenance of medical apparatus and their parts; providing temporary use of online non-downloadable computer programs for managing data of medical analyzers; chemical research and analysis; DNA testing and sequencing for scientific research; scientific testing and research relating to cell analysis; research and analysis in laboratories, namely, laboratory research in the field of gene or protein in biological samples; online remote monitoring by computer system for repair or maintenance of measuring apparatus and instruments; online remote monitoring by computer system for repair or maintenance of electronic machines, apparatus and their parts; consultancy relating to quality control; molecular biomarker analysis, namely, molecular biomarker testing services for scientific and research purposes; online remote monitoring by computer system for repair or maintenance of scientific apparatus and instruments; providing temporary use of online non-downloadable computer programs for analysis and diagnostics of clinical laboratories; providing temporary use of online non-downloadable computer programs for management of clinical laboratories; interior design services including space planning and layout design of laboratories; providing design information of antibody modification; research, testing, and development services in the field of antibody modification technologies for scientific research purposes; interior design services including space planning and layout design of operating room providing medical information, clinical test information and quality control information related to diagnosis, monitoring and treatment of disease, via computer terminal communications and the Internet; Providing information on health and health management through computer terminal communication and the Internet; counseling, advice, guidance on health and health management, and providing information thereof; providing medical information; rental of medical apparatus and instruments; providing information about quality control of clinical testing; providing medical information via web sites; providing health information via web sites; providing cancer screening services; testing services for companion diagnostics, namely, diagnostic testing of collected blood or tissue samples to determine drug applicability to specific patients; medical services, namely, medical testing, medical diagnosis, surgery, and treatment by remote monitoring and operation using medical and veterinary robots and their parts and accessories; surgical assistance services; providing medical information and medical treatment information, and medical advice and medical health counseling; medical consultations; DNA screening for medical purposes; medical screening; genetic test for medical purposes; medical testing for diagnostic or treatment purposes; providing medical data/information to healthcare professionals; providing information in the field of cancer prevention, screening, diagnosis and treatment; medical testing services relating to the diagnosis and treatment of disease; medical analysis for the diagnosis and treatment of disease for humans; medical diagnostic testing and reporting services pertaining to the monitoring, diagnosis and treatment of disease; clinical laboratory testing services and reporting of test results for medical purpose
83.
SMEAR TRANSPORTING APPARATUS, SMEAR SYSTEM, AND SMEAR PREPARING APPARATUS
A smear system includes smear preparing apparatus that prepares a smear slide and a smear transporting apparatus that transports the smear slide to a smear-image capture apparatus. The smear preparing apparatus includes: a smear preparation part that smears a sample on a slide; and a smear arrangement part that places smear slides in a smear container. The smear transporting apparatus includes: a smear-container transport part that transports the smear container with the smear slides; an identification-information acquisition part that acquires identification information on whether image capturing by the smear-image capture apparatus is necessary, from each of the smear slides accommodated in the smear container positioned on a transport path of the smear-container transport part; and a smear transfer part that transfers the smear slide whose image is to be captured to the smear-image capture apparatus on the basis of the identification information acquired by the identification-information acquisition part.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
35 - Advertising and business services
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Biological preparations for medical purposes, namely, biological preparations for the treatment of cancer or blood diseases; biological tissue cultures for medical purposes; pharmaceutical preparations or biological preparations for diagnostic or medical purposes, namely, pharmaceutical and biological preparations for the treatment of cancer or blood diseases; regenerative medical products, namely blood preparations using stem cells; stem cells for medical purposes; stem cells for veterinary purposes; regenerative medical products of stem cells, namely blood-derived products; pharmaceutical preparations of stem cells, namely, pharmaceutical preparations of stem cells derived from umbilical cord blood or peripheral blood and expanded in culture for use in stem cell transplantation and regenerative therapy, in medical or clinical use; transplants, being living tissues, for medical use, namely, gene therapy products, namely, genetically engineered tissues for transplant purposes; cells for medical use; blood preparations for medical purposes, namely, blood substitute for medical use; diagnostic reagents for medical purposes; chemical reagents for medical purposes apparatus for the regeneration of stem cells for medical purposes; blood transfusion apparatus for medical purposes; medical tubing for transfusions retail store services featuring pharmaceutical, veterinary and sanitary preparations and medical supplies; retail store services featuring chemicals; retail store services featuring medical apparatus or instruments Custom manufacture or production of pharmaceuticals; custom manufacture or production of pharmaceutical materials; Custom manufacture or production of chemicals; custom manufacture of medical devices for others; custom manufacture of scientific devices for others Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; testing, inspection or research of medical apparatus or instruments; medical research; Scientific research in the nature of conducting clinical trials for others; scientific research; stem cell research services Providing medical information; regenerative medicine services; health care services, namely, therapy and diagnostic services using regenerative medicine; health care services, namely, therapy and diagnostic services using cell therapy; blood and tissue bank services, namely, collection and preservation of biological tissue, blood, and cells; stem cell bank services; medical services relating to the removal, treatment and processing of human cells; medical services relating to the removal, treatment and processing of human blood
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
35 - Advertising and business services
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Biological preparations for medical purposes; biological tissue cultures for medical purposes; pharmaceutical preparations or biological preparations for diagnostic or medical purposes; regenerative medical products; stem cells for medical purposes; stem cells for veterinary purposes; regenerative medical products of stem cells; pharmaceutical preparations of stem cells; transplants [living tissues]; cells for medical use; blood preparations; cell preparations for treatment of diseases or disorders; diagnostic reagents for medical purposes; chemical reagents for medical purposes. Medical apparatus and instruments for regenerative medicine; medical and veterinary apparatus and instruments for regenerative medicine; apparatus for the regeneration of stem cells for medical purposes; blood transfusion apparatus; medical tubing for transfusions. Retail or wholesale services for pharmaceutical, veterinary and sanitary preparations and medical supplies; retail or wholesale services for chemicals; retail or wholesale services for medical apparatus or instruments. Custom manufacture, production or processing of pharmaceuticals; custom manufacture, production or processing of pharmaceutical materials; custom production or processing of chemicals; custom manufacture of medical devices for others; custom manufacture of scientific devices for others; custom processing of human cells; processing of blood and blood products. Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; testing, inspection or research of medical apparatus or instruments; medical research; chemistry services; clinical trials; scientific research; technological research; stem cell research. Providing medical information; regenerative medicine services; therapy or diagnostic services using regenerative medicine; therapy or diagnostic services using cell therapy; collection and preservation of biological tissue, blood and cells; stem cell bank services.
Medical or veterinary diagnostic apparatus and instruments for blood analysis; Hematology analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; Blood testing apparatus; Apparatus for blood analysis for medical purposes; Blood cell analyzers for medical purposes; Cell counters, namely, apparatus for counting, analyzing or identifying cells in blood or bodily fluids; Blood cell counters; Measuring apparatus and instruments for analyzing bodily fluids for medical purposes; Smear test sample making apparatus and instruments for medical diagnostic uses; Sample preparation device for medical diagnostic uses; Sample transfer apparatus for medical diagnostic uses; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments for medical diagnostic uses; Parts and fittings for all the aforementioned goods
Medical or veterinary diagnostic apparatus and instruments for blood analysis; Hematology analyzers for medical diagnostic uses; Medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; Blood testing apparatus; Apparatus for blood analysis for medical purposes; Blood cell analyzers for medical purposes; Cell counters, namely, apparatus for counting, analyzing or identifying cells in blood or bodily fluids; Blood cell counters; Measuring apparatus and instruments for analyzing bodily fluids for medical purposes; Smear test sample making apparatus and instruments for medical diagnostic uses; Sample preparation device for medical diagnostic uses; Sample transfer apparatus for medical diagnostic uses; Sample container transfer apparatus; Sample rack transfer apparatus; Diluting apparatus and instruments for medical diagnostic uses; Parts and fittings for all the aforementioned goods
Diagnostic apparatus and instruments for medical or veterinary purposes; hematology analyzers for medical diagnostic uses; medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; blood testing apparatus; apparatus for blood analysis; blood cell analyzers; cell counters; blood cell counters; bodily fluids measuring apparatus and instruments; smear test sample making apparatus and instruments; sample preparation device for medical diagnostic uses; sample transfer apparatus; sample container transfer apparatus; sample rack transfer apparatus; diluting apparatus and instruments; parts and fittings for all the aforementioned goods.
Diagnostic apparatus and instruments for medical or veterinary purposes; hematology analyzers for medical diagnostic uses; medical diagnostic analyzers for measuring, testing or analyzing blood and other bodily fluids; blood testing apparatus; apparatus for blood analysis; blood cell analyzers; cell counters; blood cell counters; bodily fluids measuring apparatus and instruments; smear test sample making apparatus and instruments; sample preparation device for medical diagnostic uses; sample transfer apparatus; sample container transfer apparatus; sample rack transfer apparatus; diluting apparatus and instruments; parts and fittings for all the aforementioned goods.
A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
National University Corporation Tokyo Medical and Dental University (Japan)
Kyoto Prefectural Public University Corporation (Japan)
SYSMEX CORPORATION (Japan)
Inventor
Inazawa, Johji
Kuroda, Junya
Kinoshita, Masaki
Abstract
A fluorescence image analyzer has an imaging unit for capturing a first image containing at least a part of a region of a cell as an imaging target for a plurality of cells in a sample in which a target site on a chromosome is labeled with a fluorescent dye, and a second image including fluorescence generated from a fluorescent dye labeling the target site of the cell of the first image. The processing unit selects a plurality of test cells having specific morphological characteristics to be tested from a plurality of cells based on at least the first image, and extracts the bright spots of fluorescence generated from the fluorescent dye. The processing unit identifies cells with chromosomal abnormalities and/or cells without chromosomal abnormalities based on the extracted bright spots, and generates information related to the ratio of cells with chromosomal abnormalities relative to the test cells.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical reagents for medical or veterinary purposes; Diagnostic reagents for medical or veterinary purposes; In vitro diagnostic preparations and reagents for medical or veterinary purposes; Hemolytic agents for medical or veterinary purposes
93.
DISEASE DIFFERENTIATION SUPPORT METHOD, DISEASE DIFFERENTIATION SUPPORT APPARATUS, AND DISEASE DIFFERENTIATION SUPPORT COMPUTER PROGRAM
Disclosed is a disease differentiation support method for supporting disease differentiation, the disease differentiation support method including: obtaining a first parameter obtained by analyzing an image including a cell contained in a sample collected from a subject; obtaining a second parameter regarding a number of cells contained in the sample; and generating, by using a computer algorithm, differentiation support information for supporting disease differentiation, on the basis of the first parameter and the second parameter.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
94.
Transport system, sample analyzer, sample rack, and transport regulation method
A transport system includes a sample rack configured to hold a sample and comprising a notch; a rack storage unit in which the sample rack is stored; a transport path arranged to transport the sample rack moved from the rack storage unit; and a regulating member configured to regulate movement of the sample rack from the rack storage unit toward the transport path, wherein the regulating member is provided at a position corresponding to the notch provided in the sample rack, and enters an interior of the sample rack from the notch and abuts an interior wall of the sample rack as the sample rack moves from the rack storage unit toward the transport path.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
The present invention comprises: a transport state information acquisition step for acquiring transport state information of a transport vessel in which a transport object is accommodated; a positional information acquisition step for acquiring positional information of the transport vessel; an abnormality detection step for detecting an abnormality in the transport vessel on the basis of the positional information and/or the transport state information of the transport vessel; a countermeasure specification step for specifying a countermeasure for the detected abnormality; and a notification step for notifying a delivery person delivering said transport vessel of the counter measure.
Provided are an ion sensor, a method for manufacturing an ion sensor, and a method for measuring an ion, which enable reduction of variation in electric potential. This ion sensor comprises: an ion selective electrode including a first inner solid layer that contains a first insertion material and a first ion conductive ceramic, and an ion selective film disposed on the first inner solid layer; a reference electrode including a second inner solid layer containing a second insertion material and a second ion conductive ceramic, and an ionic liquid-containing film disposed on the second inner solid layer; and an insulator in which the ion selective electrode and the reference electrode are disposed.
DETECTION METHOD FOR DETECTING OCCURRENCE OF NONSPECIFIC REACTION, ANALYSIS METHOD, ANALYZER, AND DETECTION PROGRAM FOR DETECTING OCCURRENCE OF NONSPECIFIC REACTION
Disclosed is a detection method for detecting occurrence of nonspecific reaction in analysis for an antigen or an antibody contained in a biological sample with use of a measurement reagent containing an antibody or an antigen that causes antigen-antibody reaction with the antigen or the antibody in the biological sample, and the detection method includes: generating a data group about progress of antigen-antibody reaction between the antigen or the antibody contained in the biological sample and the antibody or the antigen contained in the measurement reagent; inputting the data group to a deep learning algorithm; and generating information about occurrence of nonspecific reaction, based on a result outputted by the deep learning algorithm.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Chemical preparations for scientific purposes, other than
for medical or veterinary use; chemical reagents for
scientific or research purposes; testing reagents or
preparations for non-medical use; biochemicals for
scientific or research use; assays and reagents for use in
genetic research for non-medical purposes; chemical reagents
used for DNA sequencer for research purposes; reagent kits
for use in genetic testing for non-medical purposes; dna
polymerase for scientific or research use; enzymes for
scientific or research use; chemical preparations for the
quality control of testing and calibrating scientific or
laboratory apparatus; chemical reference materials for
scientific or research use; DNA primers used for genetic
testing for scientific or research use; diluents other than
for medical or veterinary purposes; buffer solutions for
scientific purposes; chemical preparations for the quality
control of testing and calibrating medical apparatus for
medical or veterinary purposes. Diagnostic reagents and diagnostic preparations; diagnostic
reagents and diagnostic preparations for medical or
veterinary purposes; chemical reagents for medical or
veterinary purposes; assays and reagents for use in genetic
testing for medical purposes; chemical reagents used for DNA
sequencer for medical purposes; reagent kits for use in
genetic testing for medical purposes; DNA polymerase for use
in medical analysis; enzymes for medical analysis; chemical
reference materials for medical use; DNA primers used for
genetic testing for medical purposes; diluents for medical
or veterinary use; buffer solutions for medical or
veterinary use. Laboratory apparatus and instruments; measuring or testing
machines and instruments; electronic testing apparatus,
other than for medical purposes; genetic testing apparatus
for non-medical purposes; genetic testing apparatus and
instruments for scientific, research or laboratory use; gene
amplification analyzers for scientific, research or
laboratory use; DNA sequencer for scientific, research or
laboratory use; biological sample pretreatment apparatus and
instruments for scientific, research or laboratory use; cell
analysis apparatus and instruments for scientific, research
or laboratory use; protein analysis apparatus and
instruments for scientific, research or laboratory use;
pipette tips for scientific, research or laboratory use;
microplates for laboratory experiment; primer-prepacked
plates for laboratory experiment; laboratory apparatus and
instruments used for genetic testing for scientific,
research or laboratory purposes; computer programs; computer
programs for use in the field of scientific or laboratory
analysis; computer programs for use in the field of medical,
clinical or diagnostic analysis; electronic publications;
computer programs for genetic, cell and protein analysis. Medical apparatus and instruments; medical and veterinary
apparatus and instruments; testing apparatus and instruments
for medical or clinical use; diagnostic apparatus and
instruments for medical or clinical use; genetic testing
apparatus and instruments for medical or clinical use; gene
amplification analyzers for medical or clinical use; DNA
sequencer for medical or clinical use; biological sample
pretreatment apparatus and instruments for medical or
clinical use; measurement sample preparation apparatus and
instruments for medical or clinical use; pretreatment
apparatus and instruments for genetic testing for medical or
clinical use; pipette tips for medical analysis; measuring
apparatus and instruments for use in medical analysis;
primer-prepacked plates for medical or clinical use. Scientific and technological research in the field of
genetic testing; scientific research, scientific analysis,
and design relating thereto in the field of genetic testing;
design and development of diagnostic reagents; analytical
testing services for others in the field of genetic testing;
testing services to detect or quantify gene mutations, gene
variations, gene amplification, gene loss and gene fusion
for scientific and research purposes; DNA screening for
scientific and research purposes; molecular biomarker
testing services for scientific and research purposes; DNA
sequencing services for scientific and research purposes;
testing services for research in gene analysis; testing and
research relating to cell or protein analysis for scientific
purposes; providing computer programs on data networks;
providing online non-downloadable computer programs for use
in the field of scientific and laboratory analysis;
providing online non-downloadable computer programs for use
in the field of medical, clinical or diagnostic analysis;
providing online non-downloadable computer programs for
genetic, cell or protein analysis. Providing medical information; providing medical
data/information to healthcare professionals; medical
diagnostic testing and reporting services pertaining to the
monitoring, diagnosis and treatment of diseases; testing
services to provide information regarding disease conditions
and disease prevention; diagnostic services, namely, medical
diagnostic testing for diseases and disorders.
99.
SMEAR STAINING APPARATUS, SMEAR PREPARING APPARATUS, AND SMEAR STAINING METHOD
A smear staining apparatus may include: a chamber part in which glass slides can be placed and that is configured to contain a staining solution for staining a smear on each of the glass slides; a cover part that covers the chamber part from above and comprises an insertion hole through which the glass slides are transported to the chamber part; and a transport part that transports the glass slides to the chamber part through the insertion hole.
Disclosed is a specimen smearing apparatus including: a slide supplying section configured to supply a glass slide yet to be processed; a first processing section configured to perform a first process on the glass slide, the first processing section being disposed in a first direction with respect to the slide supplying section, the first direction being a far direction of an apparatus body of the specimen smearing apparatus; a second processing section configured to perform on the glass slide a second process which is different from the first process, the second processing section being disposed in a second direction with respect to the first processing section, the second direction being a left-right direction of the apparatus body and orthogonal to the first direction; and a first drying processing section disposed in a third direction with respect to the second processing section, the third direction being a near direction of the apparatus body and opposite to the first direction, the first drying processing section configured to dry a specimen on the glass slide on which the first process and the second process have been performed, wherein one of the first processing section and the second processing section is configured to perform a smearing process for smearing a specimen on the glass slide.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
