A solid phase carrier (1) used to measure a target object includes a substrate (10), and a nano-structure (20) disposed on one surface of the substrate (10), wherein: the nano-structure (20) includes a plasmon excitation layer (21) which is formed from a substance capable of exciting surface plasmon resonance, and which has a nano-structure in which localized surface plasmon resonance is excited through irradiation of light, and a covering layer (25) formed from a substance that does not excite surface plasmon resonance; the plasmon excitation layer (21) has a covered region (21a) covered by the covering layer (25), and a non-covered region (21b) not covered by the covering layer (25); the non-covered region (21b) includes a hot spot in which localized surface plasmon resonance occurs; and a surface of the covering layer (25) has a lower binding affinity with respect to a specific binding substance of the target object than a surface of the plasmon excitation layer (21).
The present invention provides a wound treatment device with which there is no increase in infection or delay in healing due to, inter alia, an irrigation liquid leakage or foam adjustment, embedment, or replacement, and that can effectively protect the surroundings of a wound and can be easily handled without requiring skill. The present invention also provides a wound covering used therein. The present invention provides a wound treatment device characterized by comprising a wound covering constituted from a flexible laminate including a porous member and a watertight film member laminated on the porous member, a negative pressure supply pump for supplying negative pressure to the porous member side, an irrigation fluid pump for supplying an irrigation fluid to the porous member side and discharging the irrigation fluid from the porous member side, a canister for intaking the discharged irrigation fluid, and a control unit for controlling the negative pressure supply pump and the irrigation fluid pump, the wound treatment device performing negative pressure wound therapy and irrigation on the wound covered on the porous member side by the wound covering.
A61M 27/00 - Drainage appliances for wounds, or the like
A61F 13/00 - Bandages or dressings; Absorbent pads
3.
METHOD FOR MEASURING EXTRACELLULAR VESICLES, METHOD FOR ACQUIRING INFORMATION ON NEURODEGENERATION, METHOD FOR ISOLATING EXTRACELLULAR VESICLES AND REAGENT KITS
The present invention pertains to a method for measuring extracellular vesicles. The present invention pertains to a method for acquiring information on neurodegeneration. The present invention pertains to a method for isolating extracellular vesicles. The present invention pertains to reagent kits that are to be used in these methods.
The present invention pertains to a method for assisting the determination of lung cancer prognosis, said method comprising measuring miR-21C in a measurement sample prepared from a specimen of a lung cancer patient, wherein the expression level of miR-21C obtained by the measurement serves as an indicator of the lung cancer prognosis. The present invention also pertains to a reagent kit to be used in this method.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
5.
IMAGING METHOD, FOCUS POSITION ADJUSTMENT METHOD, AND MICROSCOPE SYSTEM
An imaging method for capturing an image of a sample in a microscope system comprises: a step (step S4) for, on the basis of a plurality of captured images obtained by capturing images of the sample while changing the relative position of the focus of a light receiving optical system to the sample, determining a plurality of relative positions that serve as candidates; a step (step S6) for determining a relative position for performing imaging from among the plurality of relative positions that serve as the candidates; and a step (step S10) for performing imaging on the sample at the determined relative position.
The present invention comprises: a transport state information acquisition step for acquiring transport state information of a transport vessel in which a transport object is accommodated; a positional information acquisition step for acquiring positional information of the transport vessel; an abnormality detection step for detecting an abnormality in the transport vessel on the basis of the positional information and/or the transport state information of the transport vessel; a countermeasure specification step for specifying a countermeasure for the detected abnormality; and a notification step for notifying a delivery person delivering said transport vessel of the counter measure.
Provided are an ion sensor, a method for manufacturing an ion sensor, and a method for measuring an ion, which enable reduction of variation in electric potential. This ion sensor comprises: an ion selective electrode including a first inner solid layer that contains a first insertion material and a first ion conductive ceramic, and an ion selective film disposed on the first inner solid layer; a reference electrode including a second inner solid layer containing a second insertion material and a second ion conductive ceramic, and an ionic liquid-containing film disposed on the second inner solid layer; and an insulator in which the ion selective electrode and the reference electrode are disposed.
The purpose of the present invention is to enable the automation of the analysis of cells contained in different types of specimens respectively collected from different organs or sites. This sample preparation method is a method for preparing a sample for use in the analysis of cells 51 contained in a specimen 50, and comprises: a step for acquiring a dispersion condition 60 corresponding to the type of the specimen 50; and a step for dispersing the aggregated cells 51 contained in the specimen 50 under the acquired dispersion condition 60.
The present invention addresses the problem of providing a polypeptide with further reduced binding properties with respect to D-biotin, and which strongly binds to L-biotin. Provided is a polypeptide belonging to the avidin-streptavidin family, wherein of amino acid residues other than glycine in the polypeptide, not less than 90% of the amino acid residues include a D-amino acid residue, the polypeptide having binding capacity with respect to L-biotin and having substantially no binding capacity with respect to D-biotin.
C07K 14/36 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptomyces (G)
C07K 17/00 - Carrier-bound or immobilised peptides; Preparation thereof
C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Provided are a cell analysis method and a cell analysis device which can process cell data of a significantly increased information amount with required processing capacity in a configuration for analyzing data obtained from a plurality of cells included in a specimen. In the cell analysis device which includes a host processor and a parallel processing processor, the cell analysis method comprises: acquiring data pertaining to each of the plurality of cells included in the specimen on the basis of a control by the host processor; executing parallel processing for the data by means of the parallel processing processor; and generating information about the cell type for each of the plurality of cells on the basis of the result of the parallel processing.
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
A configuration for analyzing data about cells measured by a cell measurement device wherein cell classification accuracy is improved without requiring the cell measurement device to have a high information processing capacity. This cell analysis method involves, by means of a cell analysis device for analyzing cells using an artificial intelligence algorithm, acquiring data about cells measured by a cell measurement device, analyzing the data and generating information about the cell type for each of the cells, and transmitting the information to the cell measurement device.
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 33/483 - Physical analysis of biological material
A dispensing system (100) is such that a torso unit (11) is disposed outside a specimen processing cabinet (40), and, with a hand unit (22) and a dispensing unit (33) inserted into the specimen processing cabinet (40), the dispensing unit (33) dispenses, to a dispensing container (8), specimens contained in a specimen container (7) gripped by the hand unit (22).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 1/00 - Sampling; Preparing specimens for investigation
13.
DISEASE IDENTIFICATION ASSISTING METHOD, DISEASE IDENTIFICATION ASSISTING DEVICE, AND DISEASE IDENTIFICATION ASSISTING COMPUTER PROGRAM
The present invention addresses the problem of providing a disease identification assisting method, a disease identification assisting device, and a disease identification assisting computer program which make it possible to assist in disease identification by simply preprocessing a sample. The problem is addressed by a disease identification assisting method for assisting in the identification of a disease, the method involving: acquiring a first parameter group including first parameters obtained by analyzing an image including cells included in a sample extracted from a subject; acquiring a second parameter group including second parameters obtained by analyzing optical signals or electrical signals obtained from the cells included in the sample; and generating, by using a computer algorithm, identification assistance information for assisting in the identification of the disease on the basis of the first parameter group and the second parameter group.
This invention relates to a method for improving antibody affinity with antigen. This invention relates to modified antibody having improved affinity with antigen compared to unmodified antibody. This invention relates to a method for producing antibody having improved affinity with antigen when compared to unmodified antibody. This invention relates to a method for analyzing the amino acid sequence of antibody. This invention relates to a method for identifying candidates for antibody modification sites.
The present invention relates to a method for improving the affinity of an antibody to an antigen. The present invention relates to a method for producing an antibody having a more improved affinity to an antigen than an unmodified antibody. The present invention relates to a modified antibody having a more improved affinity to an antigen than an unmodified antibody.
Provided is an electrode that exhibits higher potential-stability when used repeatedly and/or over a long period of time in an ion sensor. The electrode comprises: an electrode material; and an internal solid-state layer containing a metal oxide and a solid electrolyte.
The present invention addresses the problem of providing a new artificial nucleic acid, a production method therefor, and a use thereof. The problem can be solved by an artificial nucleic acid having a unit derived from a compound represented by formula (1) or a salt thereof (in the formula, Base represents an aromatic heterocyclic ring group optionally having a substituent or an aromatic hydrocarbon ring group optionally having a substituent, A1represents a straight-chain alkylene group, A2represents a single bond or an alkylene group, X represents an alkylene group optionally having a substituent, R1and R2are the same or different from each other and each represent a hydrogen atom, an alkyl group optionally having a substituent, an alkenyl group optionally having a substituent, a cycloalkyl group optionally having a substituent, a cycloalkenyl group optionally having a substituent, an aryl group optionally having a substituent, a protecting group of a hydroxyl group, a phosphino group having a substituent, a dihydroxyphosphinyl group optionally having a substituent, or a hydroxymercaptophosphinyl group optionally having a substituent, or R1and R2, together with two oxygen atoms respectively adjacent thereto and carbon atoms at positions 3-5 of a furanose, form a ring optionally having a substituent, and R3 represents an amino group optionally having a substituent).
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical
C07H 19/167 - Purine radicals with ribosyl as the saccharide radical
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
18.
CELL ANALYSIS METHOD, TRAINING METHOD FOR DEEP LEARNING ALGORITHM, CELL ANALYSIS DEVICE, TRAINING METHOD FOR DEEP LEARNING ALGORITHM, CELL ANALYSIS PROGRAM, AND TRAINING PROGRAM FOR DEEP LEARNING ALGORITHM
The present invention determines a cell type that has not been able to be determined in a conventional scattergram. The present invention addresses an issue by means of a cell analysis method, which analyzes a cell included in a biological sample by using a deep learning algorithm of a neural network structure, the method including: flowing the cell to a passage; acquiring a signal strength pertaining to each cell passing in the passage; inputting, to a deep learning algorithm, numerical data corresponding to the acquired signal strength pertaining to each cell; and determining, on the basis of an output result from the deep learning algorithm for each cell, the type of the cell for which the signal strength is acquired for each cell.
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
The present invention prevents a specimen from remaining on a surface of a suction tube after being pulled out of a specimen container. The specimen container 100 comprises a container body 20 having an opening 21, a cap 10 that is disposed so as to close the opening 21 of the container body 20 and includes a slit forming portion 11 in which is formed a slit 11a enabling passage of a suction tube 30, and a contact portion 12 that is provided in a position different from the position of the slit 11a and comes into contact with an outer peripheral surface 31 of the suction tube 30 at least when the suction tube 30 is pulled out of the slit 11a.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
The present invention suppresses leakage of liquid from a sample container. This sample container 100 comprises: a container body 20 that has an opening 21; and a cap 10 that is arranged to plug the opening 21 of the container body 20 and has formed therein a slit 111 through which a suction tube 30 can pass. The cap 10 includes: a slit formation part 11 in which the slit 111 is formed; and an elastic part 12 that surrounds the slit formation part 11 and elastically deforms to movably support the slit formation part 11.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
21.
METHOD FOR DETECTING TARGET SUBSTANCE, REAGENT FOR DETECTING TARGET SUBSTANCE, AND REAGENT KIT FOR DETECTING TARGET SUBSTANCE
Wisteria floribundaWisteria floribunda177 alcohol consisting of a carbon atom, a hydrogen atom, and an oxygen atom, to produce a complex that contains, on the carrier, the WFA and the target substance; and a step for detecting the target substance by detecting the complex.
The present invention relates to a method for analyzing immune cells, the method including: a step for mixing whole blood containing immune cells and an immune stimulation factor in vitro, and labeling a target molecule of the immune cells; and a step for detecting the label to obtain information regarding the location of the target molecule on immune cells. The present invention also relates to an instrument that analyzes cells obtained by mixing whole blood containing immune cells and an immune stimulation factor in vitro, and causing a target molecule to be present on the immune cells.
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (Japan)
SYSMEX CORPORATION (Japan)
Inventor
Miyazaki, Yasunari
Nukui, Yoshihisa
Hasegawa, Takehiro
Abstract
The present invention relates to a method for obtaining information on the risk of reduced respiratory function in a patient with interstitial pneumonia. The present invention relates to a method for determining the risk of reduced respiratory function in a patient with interstitial pneumonia. The present invention relates to an apparatus and computer program for determining the risk of reduced respiratory function in a patient with interstitial pneumonia.
The present invention pertains to an enzymatic measurement method and a reagent for enzymatic measurement. The enzymatic measurement method comprises a step for contacting a short-chain fatty acid having 3-6 carbon atoms in a sample with adenosine triphosphate and butyrate kinase to form adenosine diphosphate and then measuring the thus formed ADP. The reagent for enzymatic measurement comprises butyrate kinase and adenosine triphosphate.
Provided is a flow cytometer in which detection of light produced from particles is not readily affected by changes in the flow velocity of a liquid flowing within a flow cell. This flow cytometer is provided with a flow cell (10) in the interior of which a liquid flows, a liquid sending unit (40) for sending the liquid into the flow cell (10), a control unit (300) for acquiring information pertaining to the flow velocity of the liquid flowing within the flow cell (10), a light source (121) for irradiating the liquid flowing within the flow cell (10) with light, and a detector (162) for detecting light produced from particles in the liquid that was irradiated with light, the liquid sending unit (40) changing liquid sending conditions on the basis of the information pertaining to the flow velocity as acquired by the control unit (300).
Provided are a specimen measurement system and a rack conveyance method with which the supply of consumable articles to a plurality of specimen measurement units can be carried out collectively. A specimen measurement system (100) comprises: a plurality of specimen measurement units (1a, 1b) that perform measurement of a specimen using a consumable article; a consumable article rack disposition unit (21) in which consumable article racks are disposed; a first conveyance path (F) for supplying the consumable article racks disposed in the consumable article rack disposition unit (21) to each of the plurality of specimen measurement units (1a, 1b); a consumable article rack collection unit (22) that collects empty racks which have become empty after passing through at least one of the plurality of specimen measurement units (1a, 1b); and a second conveyance path (R) that conveys the empty racks to the consumable article rack collection unit (22).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
27.
SPECIMEN MEASUREMENT SYSTEM AND RACK CONVEYANCE METHOD
Provided are a specimen measurement system and a rack conveyance method with which a reduction in processing capacity caused by a stagnation in the supply of consumable articles to specimen measurement units can be suppressed in the specimen measurement system comprising a plurality of the specimen measurement units. A specimen measurement system (100) comprises: a first conveyance path (F) for conveying a consumable article rack which accommodates a plurality of consumable articles from a consumable article disposition unit (2) to at least one of a plurality of specimen measurement units (1a, 1b); and a second conveyance path (KF) for conveying a specimen rack which accommodates a plurality of specimens from a specimen disposition unit (4) to at least one of the plurality of specimen measurement units (1a, 1b).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
28.
RACK CONVEYANCE METHOD AND SPECIMEN MEASUREMENT SYSTEM
Provided are a rack conveyance method and a specimen measurement system with which the horizonal dimension of a system comprising a plurality of specimen measurement units can be kept small while providing a plurality of conveyance paths for conveying a rack which accommodates a plurality of containers to a specimen measurement unit. A specimen measurement system (100) comprises: a specimen conveyance path (KF) for conveying a specimen rack which accommodates a plurality of specimens from a specimen disposition unit 4 to a specimen measurement unit (1a, 1b); a specimen collection path (KR) that is provided at a position different in the height direction from the specimen conveyance path (KF), and that collects the specimen rack from the specimen measurement unit (1a, 1b) to the specimen disposition unit 4; and a transport mechanism (181a, 181b) that transports the specimen rack from the specimen conveyance path (KF) to the specimen collection path (KR).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
29.
METHOD AND REAGENT FOR MEASURING UPTAKE PERFORMANCE OF LIPOPROTEIN
The present invention addresses the problem of providing a method and a reagent for measuring the uptake performance of a lipoprotein in a highly accurate manner. The above problem is solved by mixing an in-sample lipoprotein and an indicator sterol in the presence of a surfactant that does not include a cyclic structure, whereby the lipoprotein that has taken up the indicator sterol is adjusted, and measuring the uptake performance of the lipoprotein with respect to the indicator sterol.
The present invention relates to a method for assisting the determination of the efficacy of an immune checkpoint inhibitor. The present invention also relates to a reagent kit for use in this method. The present invention further relates to a device and computer program for determining the efficacy of an immune checkpoint inhibitor.
Provided are a particle measuring device and a particle measuring method with which it is possible to reduce the time and effort required for positional adjustment of an optical fiber, and to maintain a state in which light enters the optical fiber appropriately. A particle measuring device (10) includes: a flow cell (20) for causing a sample (11) containing a particle to flow; a radiating unit (30) which radiates radiating light onto the sample (11) flowing through the flow cell (20); a condensing lens (42) which condenses light generated from the particle contained in the sample (11) as a result of the radiation by the radiating light; an optical transmission unit (50) which is formed by bundling a plurality of optical fibers (51) and into which the light that has passed through the condensing lens (42) enters; and a light detecting unit (61) which receives the light that has been transmitted by the optical transmission unit (50), and outputs a detection signal.
The objective of the present invention is to improve the freedom of device configuration. This BF separating device (100) is provided with: a holding unit (10) for holding a container (90) accommodating a sample containing magnetic particles and a liquid component; a magnet (20) which is provided in such a way as to be capable of relative movement in a direction approaching or moving away from the holding unit (10), and which is used to magnetically collect the magnetic particles; a movement mechanism (30) for moving the holding unit (10), and, in conjunction with the movement of the holding unit (10), for moving the magnet (20) in a direction such that the holding unit (10) and the magnet (20) approach one another or move away from one another; an agitating unit (40) for agitating the sample in the container being held by the holding unit (10) in a separated position (62) in which the holding unit (10) and the magnet (20) are separated from one another; and a suction pipe (50) for sucking the liquid component in the container being held by the holding unit (10) in an close position (61) in which the holding unit (10) and the magnet (20) are close to one another.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
33.
METHOD FOR CONFIRMING STATE OF IMMUNOASSAY DEVICE, AND IMMUNOASSAY DEVICE
The objective of the present invention is to enable the state of a function for carrying out immunoconjugate transfer in an immunoassay device to be confirmed in a simple manner. This method for confirming the state of an immunoassay device (100) is a method for confirming the state of the immunoassay device (100) which performs an immunoconjugate transfer process in which an immunoconjugate (84), supported on the solid phase carrier (22) and including a substance (81) being tested for in a sample and a labeling substance (21), is liberated from the solid phase carrier (22) in a first container (11) accommodating the immunoconjugate (84), and a liquid phase in the first container (11) is transferred to a second container (12), wherein the method includes: a step of transferring the liquid phase in the first container (11) accommodating a control sample (20) containing at least the labeling substance (21) to the second container (12); a step of detecting the labeling substance (21) in the second container (12) to which the liquid phase has been transferred; and a step of assessing the state of the immunoassay device (100) which performs the immunoconjugate transfer process, on the basis of the detection result of the labeling substance (21) in the second container (12).
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
According to the present invention, false positives caused by a medical agent having a thiol group are suppressed when measuring ketone bodies in urine. An oxidizing agent is added to this specimen for detecting ketone bodies in urine, thereby suppressing false positives caused by a medical agent having a thiol group.
G01N 33/64 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
35.
METHOD FOR EVALUATING STATE OF UNDIFFERENTIATED CELL AND UTILIZATION THEREOF
The present invention addresses the problem of providing a method capable of evaluating the state of undifferentiated cells without destroying cells. The abovementioned problem is solved by providing a method for evaluating the state of undifferentiated cells, said method including: a step for measuring at least one miRNA selected from among miR371, miR372, and miR373 in a liquid phase fraction of a liquid containing undifferentiated cells; and a step for evaluating the state of said undifferentiated cells on the basis of the measurement value of said miRNA.
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
A specimen measurement device which efficiently keeps cool or warm a reagent and which suppresses increases in the number of components, a reagent container, and a specimen measurement method are provided. This specimen measurement device is provided with a reagent container holder 30 which holds suspended reagent containers 200 containing a reagent, and a measurement unit 10 which uses a reagent to measure a specimen.
Provided are a nucleic acid analysis device, said device enabling proper installation of containers relative to the device, and a nucleic acid extraction device. The nucleic acid analysis device 100 comprises: a plurality of amplification container installation parts 120 wherein amplification containers 20, in which a nucleic acid-containing extract is poured and a reagent for amplifying the nucleic acid in the extract is housed, are respectively installed; a display part 402; and a control part 401 which makes the display part 402 display a screen 500 where the arrangement positions of the respective amplification container installation parts 120 are associated with information concerning the installation of the amplification containers 20 relative to the amplification container installation parts 120.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
38.
SPECIMEN MEASUREMENT DEVICE AND METHOD FOR CIRCULATING AIR IN REAGENT STORAGE
A specimen measurement device which suppresses increases in the bulkiness of the device and suppresses increases in the number of components, and a method for circulating air in a reagent storage are provided. This specimen measurement device 100 is provided with a measurement unit 10 which uses a reagent stored in a reagent container 200 to measure a specimen; a reagent storage 20 which stores reagent containers 200; a reagent container holder 30 which is arranged in the reagent storage 20 and which holds reagent containers 200; a drive unit 50 which rotationally drives the reagent container holder 30; and a fin 40 which is driven to rotate coupled with the reagent container holder 30 and which circulates the air in the reagent storage 20.
A specimen measurement device which, when aspirating a reagent from a reagent container having an openable and closable lid, ensures a high degree of sealabilty by the lid even when performing opening and closing operations of the lid, a reagent container and a specimen measurement method are provided. This specimen measurement device 100 is provided with: a container holding unit 10 for holding a reagent container 200 having an openable and closable lid 220 that covers the opening 210; a reagent dispensing unit for aspirating the reagent in the reagent container 200 with the lid 220 in a closed state and dispensing the aspirated reagent into a reactor 50; a pressing unit 20 for pressing the lid 220, which has been moved to a position covering the opening 210, towards the opening 210 to seal the opening 210; and a measurement unit 44 for measuring a component contained in a measurement sample, which has been prepared from the reagent and the specimen dispensed into the reactor 50.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
40.
GENE ANALYSIS METHOD, GENE ANALYZER, MANAGEMENT SERVER, GENE ANALYSIS SYSTEM, PROGRAM AND RECORDING MEDIUM
To improve user convenience in analyzing gene sequences using various gene panels. A gene analyzer (1) for analyzing gene sequence information comprises: a control unit (11) acquiring read sequence information read out by a sequencer (2) and information relating to a plurality of analyte gene-containing panels; and an output unit (13) outputting analysis results of the read sequence information based on the information relating to the panels acquired by the control unit (11).
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G16B 99/00 - Subject matter not provided for in other groups of this subclass
41.
EFFECTOR TYPE REGULATORY T CELL DETECTING METHOD, EFFECTOR TYPE REGULATORY T CELL ANALYZING DEVICE, EFFECTOR TYPE REGULATORY T CELL ANALYZING SYSTEM, AND PROGRAM
In this method for detecting effector type regulatory T cells using flow cytometry: a control sample containing a population of CD4-positive T cells is measured; on the basis of the control sample measurement results, a FOXP3 quantity serving as a dividing reference when a population of FOXP3-positive T cells contained in the population of CD4-positive T cells is divided in accordance with a prescribed ratio is acquired as a reference value to be used when measuring a biological sample; a biological sample containing a population of CD4-positive T cells is measured; and on the basis of the biological sample measurement results, effector type regulatory T cells are detected from a population of cells in which the FOXP3 quantity is greater than the reference value.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
G01N 33/483 - Physical analysis of biological material
The present invention addresses the problem of acquiring an antibody that is capable of binding to a high density lipoprotein regardless of the modified state of the high density lipoprotein and regardless of the presence or absence of a labeled cholesterol introduced thereinto. Provided is a monoclonal antibody or an antigen-binding fragment thereof that binds to a peptide comprising an amino acid sequence consisting of the 51- to 110-amino acids in the amino acid sequence represented by SEQ ID NO: 1 or a peptide comprising an amino acid sequence consisting of the 201- to 267-amino acids therein, and is capable of binding to high density lipoproteins (1) to (3): (1) an oxidation-modified high density lipoprotein; (2) a high density lipoprotein being not oxidation-modified; and (3) a high density lipoprotein having a labeled cholesterol introduced thereinto.
The present invention pertains to a perfusion device and perfusion method for culturing undifferentiated cells using an organ or tissue taken from an organism.
Provided are an accuracy management method, an accuracy management system, a management device, an analysis device, and a method for determining an abnormality in accuracy management, whereby the quality of accuracy management can be increased by adequately utilizing measurement results for both an accuracy management material and a sample. An accuracy management method used by a management device 30 connected via a network 13 to analysis devices 20 installed in each of a plurality of facilities 12, wherein first accuracy management information obtained by measurement of an artificially generated accuracy management material by the analysis device 20 of each facility 12 and second accuracy management information obtained by measurement of a plurality of samples are acquired via the network 13 from the analysis device 20 of each facility 12, and information relating to accuracy management of the analysis device 20 of at least one facility 12 is outputted on the basis of the acquired first accuracy management information and the second accuracy management information.
To provide a method whereby pluripotent stem cells can be detected at a high sensitivity without disrupting the cells after inducing differentiation. The present invention provides a method which comprises measuring miRNA in miR302/367 cluster in a liquid phase fraction of a cell culture liquid during and/or after inducing differentiation of pluripotent stem cells and evaluating the differentiation state of the cells in the cell culture liquid on the basis of the measurement value of miRNA. The present invention also provides a method for detecting pluripotent stem cells, said method comprising a step for measuring miRNA in miR302/367 cluster in a liquid phase fraction of a cell culture liquid during and/or after inducing differentiation of pluripotent stem cells and a step for detecting the pluripotent stem cells in the cell culture liquid on the basis of the measurement value of miRNA.
KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (Japan)
SYSMEX CORPORATION (Japan)
SANTEN PHARMACEUTICAL CO., LTD. (Japan)
Inventor
Tashiro, Kei
Kinoshita, Shigeru
Mori, Kazuhiko
Ikeda, Yoko
Ueno, Morio
Nakano, Masakazu
Sato, Ryuichi
Sato, Fumiko
Yoshii, Kengo
Abstract
A method for assisting the diagnosis of the risk of developing exfoliation syndrome or exfoliation glaucoma in a subject, said method comprising: an allele measurement step of measuring alleles for at least 30 single nucleotide polymorphisms (SNPs) including the 12 core SNPs listed in Table 1 and SNPs selected from the pool SNPs listed in Table 2 (selected pool SNPs), on the basis of SNP allele information in a biological sample collected from the subject; an information acquisition step of acquiring information about the risk of developing exfoliation syndrome or exfoliation glaucoma in the subject on the basis of the results of the measurement of the alleles; and an information provision step of providing information for determining the risk of developing exfoliation syndrome or exfoliation glaucoma in the subject on the basis of the information acquired in the preceding step. According to the method of the present invention, it becomes possible to determine the presence or absence of the risk of developing exfoliation syndrome or exfoliation glaucoma in a subject and predict the degree of the aforementioned risk in the subject, by analyzing SNPs of the present invention occurring in a sample from the subject.
KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (Japan)
SYSMEX CORPORATION (Japan)
SANTEN PHARMACEUTICAL CO., LTD. (Japan)
Inventor
Tashiro, Kei
Kinoshita, Shigeru
Mori, Kazuhiko
Ikeda, Yoko
Ueno, Morio
Nakano, Masakazu
Sato, Ryuichi
Sato, Fumiko
Yoshii, Kengo
Abstract
A method for assisting the diagnosis of a subject's risk of onset of primary open-angle glaucoma (broadly defined) including an allele measurement step that measures the alleles of at least 30 single nucleotide polymorphisms (SNP) including the core SNP group of 12 listed in table 1 and SNP selected from the pool SNP group listed in table 2 (pool-selected SNP group) on the basis of SNP allele information in a biological sample collected from a subject, an information acquisition step that acquires information on the subject's risk of onset of primary open-angle glaucoma (broadly defined) on the basis of the allele measurement results, and an information provision step that provides information for determining the subject's risk of onset of primary open-angle glaucoma (broadly defined) on the basis of the information obtained above. This method determines whether a sample provider is at risk of onset of POAG (broadly defined) by analyzing the SNP groups of the invention present in the sample and can also predict the level of risk.
This nucleic acid analysis device 100 is provided with: a first container placement unit 110 for placing first containers 10, which contain a reagent for nucleic acid extraction, such that multiple reagent container units in the first container 10 are arranged along the X axis; a dispensing unit 140 which, from the first container 10, transports along the X axis an extract solution, which contains nucleic acids extracted in the first container 10 using a reagent for nucleic acid extraction; a second container placement unit 124 for placing second containers 20 which include, arranged along the X axis, an injection port 21 for injecting the extract solution transported by the dispensing unit 140, multiple container units 22 which contain a reagent for amplifying nucleic acids in the extract solution, and flow paths 23 for connecting the injection port 21 and the multiple container units 22; and a detection unit 240 which detects the nucleic acid amplification reaction occurring in the multiple container units 22.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
49.
NUCLEIC ACID ANALYSIS DEVICE AND NUCLEIC ACID ANALYSIS METHOD
This nucleic acid analysis device 100 is provided with: a container placement unit 210 in which second containers 20 are arranged; a rotation driving unit 220 which rotates the container placement unit 210 by applying a drive force to the surface of the container placement unit 210, and sends an extract solution injected from an injection port 21 through a flow path 23 to a container unit 22 by means of centripetal force; a first temperature adjustment unit 230 which adjusts the temperature of the second containers 20 placed in the container placement unit 210 such that a nucleic acid amplification reaction occurs in the container unit 22; and a detection unit 240 which holds a second container 20, which is arranged in the container placement unit 210, vertically between said detection unit and the first temperature adjustment unit 230, detects the nucleic acid amplification reaction occurring in the container unit 22.
The present invention relates to: a method for assisting the prediction of recurrence risk in a hepatocellular carcinoma patient; a device; a computer program product; and a kit.
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
51.
ANALYTE DETECTION METHOD AND REAGENT KIT FOR DETECTING ANALYTE
Provided is an analyte detection method comprising: a step for forming an immune complex on a first solid phase by contacting a first solid phase with an analyte, a labeled antibody, and a capture antibody; a step for releasing the immune complex by dissociating the bond between the capture antibody and the first solid phase, and contacting the immune complex with a second solid phase that binds the capture antibody, thereby transferring the immune complex onto the second solid phase; and a step for detecting the analyte by measuring the label present in the complex on the second solid phase. The analyte detected by this method is a multimeric antigen, in particular amyloid-β or tau protein.
This sample staining device is provided with: a tank part which allows a plurality of glass slides to be disposed therein and is designed to store a stain solution for staining a sample on the glass slide; a cover part which has an insertion port for inserting the glass slide and covers the tank part from above; and a transfer part for transferring the glass slide to the tank part via the insertion port.
Provided are a biological sample imaging device and a biological sample imaging method with which it is possible to set large-sized particles contained in a biological sample into an imaging range, in sufficient numbers and in a suitably dispersed manner. The biological sample imaging method includes: a first step for introducing a biological sample (104) containing particles into a liquid channel (40); a second step for channeling, in the forward direction, the biological sample (104) introduced into the liquid channel (40); a third step for channeling the biological sample (104) in the reverse direction after the second step; and an imaging step for imaging, in an imaging cell (14), the particles contained in the biological sample (104) remaining in the liquid channel (40) after the third step.
G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
54.
METHOD FOR DETERMINING CANCER, AND DEVICE AND COMPUTER PROGRAM FOR DETERMINING CANCER
The present invention relates to method for determining cancer. The present invention furthermore relates to a device and computer program for determining cancer.
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Provided is a specimen analysis device wherein an increase in an installation area for the specimen analysis device is restricted and preparation work is simplified while maintaining high specimen processing capability. The specimen analysis device (10) comprises: a first reagent pipetting unit (12) that suctions a reagent from a first suction position (23a); a second reagent pipetting unit (13) that suctions a reagent from a second suction position (23b); a first detecting unit (14) that measures a measurement sample including the reagent pipetted by the first reagent pipetting unit (12) and a specimen; a second detecting unit (15) that measures a measurement sample including the reagent pipetted by the second reagent pipetting unit (13) and the specimen; and a control unit (26) that controls a reagent table (23) so that the reagent related to a measurement item set so as to use the first reagent pipetting unit (12) is transferred to the first suction position (23a), and the reagent related to a measurement item set so as to use the second reagent pipetting unit (13) is transferred to the second suction position (23b).
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Provided is a sample analyzing device which can enhance sample processing ability, while reducing the installation area thereof. The sample analyzing device (10) is provided with: a warming table (11); a reagent dispensing unit (12) which dispenses a reagent to reaction containers (33); first holding units (13a) and second holding units (13c) which hold the reaction containers (33) accommodating measurement specimens prepared using the sample and the reagent; a detecting unit (13) which has first detecting units (13b) and second detecting units (13d) which detect signals for analysis from the measurement specimens in the reaction containers (33); a second control unit (24b) which performs sample analysis on the basis of the signals detected by the detecting unit (13); a first transfer unit (14) which transfers the reaction containers (33) held on the warming table (11) to any one of the holding units (13a) in a first area (13e); and a second transfer unit (15) which transfers the reaction containers (33) held on the warming table (11) to any one of the holding units (13c) in a second area (13f).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
57.
SPECIMEN TREATMENT CHIP, SPECIMEN TREATMENT DEVICE, AND SPECIMEN TREATMENT METHOD
This specimen treatment chip comprises: a first fluid module including a first flow path for executing a first treatment step with respect to a target component in a specimen; a second fluid module including a second flow path for executing a second treatment step with respect to the target component that has been subjected to the first treatment step; a substrate; and a connection flow path for connecting the first fluid module and the second fluid module, the connection flow path being arranged in the substrate.
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
58.
ANALYTE TREATMENT CHIP, ANALYTE TREATMENT DEVICE, AND ANALYTE TREATMENT METHOD
This analyte treatment chip is provided with: a first flow path for forming, in a dispersion medium, a droplet containing a mixture solution of a nucleic acid, a reagent for an amplification reaction of the nucleic acid, and a carrier to which primers which bind to the nucleic acid are added; a second flow path for amplifying the nucleic acid in the droplet; and a third flow path for destroying the droplet by mixing the droplet containing the carrier, in which amplification products of the nucleic acid are bound to the primers, with a reagent that destroys the droplet.
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
This specimen smearing device is provided with: a slide supply unit; a first processing unit disposed in a first direction with respect to the slide supply unit; a second processing unit disposed in a second direction perpendicular to the first direction with respect to the first processing unit; and a first dry processing unit disposed in a third direction opposite to the first direction with respect to the second processing unit. One of the first processing unit and the second processing unit is configured to perform a smear process for smearing a specimen onto a slide glass.
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
60.
METHOD FOR ASSISTING DIAGNOSIS OF CONDITIONS OF MYELOFIBROSIS, METHOD FOR ASSISTING PREDICTION OF PROGNOSIS, METHOD FOR MONITORING THERAPEUTIC EFFECT, AND MARKER AND DEVICE TO BE USED THEREIN
PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY (Japan)
SYSMEX CORPORATION (Japan)
Inventor
Tanaka, Yasuhito
Kusumoto, Shigeru
Takahama, Youichi
Kagawa, Takashi
Abstract
Provided are a method for assisting the diagnosis of conditions of myelofibrosis (MF), a method for assisting the prediction of prognosis of MF, and a method for monitoring a therapeutic effect on MF. Also provided is a device for performing these methods. Also provided is a marker for determining conditions of myelofibrosis.
The present invention pertains to a cell preservative solution. The present invention also pertains to a method for preserving cells, a method for preparing fixed cells, and a method for analyzing cells using a cell preservative solution. The present invention furthermore pertains to a method for producing a cell preservative solution.
C12N 1/04 - Preserving or maintaining viable microorganisms
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
C12N 11/16 - Enzymes or microbial cells immobilised on or in a biological cell
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. Furthermore, the present invention relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. Further, the present invention relates to a tagged cholesterol, which can be used in the method and the reagent kit.
This liquid encapsulation cartridge is provided with: a cartridge body including a plurality of liquid accommodating portions; a sealant for sealing the opening of each of the liquid accommodating portions; and an elastic body disposed across from the liquid accommodating portions to define a channel facing the liquid accommodating portions. The channel and each of the liquid accommodating portions are configured to be brought into communication with each other as a result of pressure on the sealant through the elastic body causing an opening.
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
B65D 83/00 - Containers or packages with special means for dispensing contents
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
64.
METHOD FOR EVALUATING COAGULATION ABILITY OF BLOOD SPECIMEN, AND REAGENT, REAGENT KIT AND DEVICE TO BE USED THEREIN
PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY (Japan)
CHUGAI SEIYAKU KABUSHIKI KAISHA (Japan)
SYSMEX CORPORATION (Japan)
Inventor
Shima, Midori
Nogami, Keiji
Matsumoto, Tomoko
Kitazawa, Takehisa
Soeda, Tetsuhiro
Ikeda, Yuka
Abstract
Provided is a method for evaluating the coagulation ability of a blood specimen that is obtained from a subject to whom a substance with an activity substituting for coagulation factor VIII has been administered. Also provided are a reagent for analyzing blood coagulation, a reagent kit for analyzing blood coagulation and a device for analyzing blood coagulation. Also provided are a device and a computer program for evaluating the coagulation ability of a blood specimen.
An immunoassay device provided with: a specimen dispensation unit for dispensing a specimen into a first reaction container; a reagent dispensation unit that dispenses a solid phase reagent and a labeling reagent into the first reaction container; a BF separation unit that separates a solid phase carrier, on which an immunocomplex containing a target substance and the labeling substance is formed, from a liquid component; a measurement unit; and a transfer unit that transfers the first reaction container. The reagent dispensation unit dispenses into the first reaction container a releasing reagent for releasing the immunocomplex from the solid phase carrier. The immunocomplex that is released from the solid phase carrier by the releasing reagent is dispensed into a second reaction container. The measurement unit measures a signal based on a label that is contained in the immunocomplex having been dispensed into the second reaction container.
A urinalysis system 1 is provided with: a testing device 10 for measuring a formed component contained in a urine sample by flow cytometry; an image-capturing device 20 for capturing an image of a formed component in a urine sample, and acquiring a cell image; and a management device 30 for receiving measurement results obtained using the testing device 10 and cell images obtained using the imaging device 20. The management device 30 generates an order to capture an image of the urine sample on the basis of the measurement results obtained using the testing device 10. When receiving an image-capturing order generated by the management device 30, the image-capturing device 20 executes a process for capturing an image of the formed element in a urine sample, and transmits an acquired cell image to the management device 30.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/483 - Physical analysis of biological material
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
67.
METHOD FOR DETECTING TEST SUBSTANCE AND REAGENT KIT USED IN SAID METHOD
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
68.
ANALYTE MEASUREMENT SYSTEM AND TRAY-IDENTIFYING INFORMATION SEARCH METHOD
[Problem] To provide an analyte measurement system and a tray-identifying information search method, with which it is possible for a user to easily locate a rack of interest. [Solution] A measurement unit 10 measures an analyte contained in an analyte container. A transport unit 20 transports racks 60 capable of holding a plurality of analyte containers, through the measurement unit 10. A rack discharge/intake unit 30 is provided with a detachable tray in which it is possible for a plurality of racks 60 to be set, and the racks 60 transported from the measurement unit 10 by the transport unit 20 are taken therein and set in the tray. On a hard disk 504, an analyte ID specifying the analyte, a rack ID specifying the rack, and a tray ID specifying the tray are stored in mutually association. A controller 500, upon receiving input of an analyte ID or a rack ID, controls a display 509 so as to display a tray ID stored in association with the analyte ID or the rack ID.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
69.
SPECIMEN MEASUREMENT SYSTEM, AND RACK LOADING AND UNLOADING METHOD
Provided are a specimen measurement system and a rack loading and unloading method with which limited space can be efficiently used. This specimen measurement system (100) comprises measurement units (10), a conveyance unit (20), a plurality of loading and unloading units (30), and a control unit (500). The loading and unloading units (30) can arrange a plurality of racks (60) in a row in a first direction, and unload the arranged racks. The conveyance unit (20) conveys the racks (60) via the measurement units (10). The loading and unloading units (30) load the racks (60) conveyed by the conveyance unit (20). The loading and unloading units (30) are arranged in a row in a second direction that intersects with the first direction, and each loading and unloading unit (30) unloads the racks (60) from one side in the first direction and loads the racks (60) from the other side in the first direction.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
70.
CELL ANALYSIS DEVICE, METHOD FOR CONTROLLING CELL ANALYSIS DEVICE, AND PROGRAM
In a processing unit 111 in a cell analysis device 10, an inactivation processing for quenching a first fluorescent dye, an activation processing for activating a portion of the quenched first fluorescent dye and an imaging processing for irradiating a cell of interest with light by a light source unit 11 to image fluorescent by an imaging unit 19 are carried out to produce a first image. In the processing unit 111, bright points derived from the first fluorescent dye are extracted in the first image, the extracted bright points are classified into groups each corresponding to one molecule of a first substance, the number of molecules of the first substance in the cell of interest is determined on the basis of the number of the classified groups, information on a treatment index that is a measure for the judgement of treatment policy is obtained on the basis of the above-determined number of molecules of the first substance, and the information on the treatment index is displayed on a display unit 120.
SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN (Japan)
SYSMEX CORPORATION (Japan)
Inventor
Ieko, Masahiro
Kumano, Osamu
Yamaguchi, Haruki
Suzuki, Takeshi
Abstract
The present invention relates to a method for acquiring information on a cause of the prolongation of a coagulation time. The present invention also relates to a device, a system and a computer program all of which can be used for the analysis of blood coagulation.
G01N 33/86 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time
G01N 21/82 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
72.
METHOD FOR ASSISTING IN PROGNOSTIC DIAGNOSIS OF COLORECTAL CANCER, RECORDING MEDIUM AND DETERMINING APPARATUS
The present invention measures an SCEL gene expression amount in a biological specimen taken from a colorectal cancer patient and assists in the prognostic diagnosis of colorectal cancer on the basis of the measured SCEL gene expression amount.
G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
G06F 19/20 - for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation
73.
METAL ION DETECTION METHOD, ANALYTE DETECTION METHOD, ELECTRODE SUBSTRATE, AND DETECTION KIT
Provided is a method for detecting an analyte. In this method, on a working electrode of an electrode substrate including the working electrode and a counter electrode, metal is deposited or a complex comprising the analyte and metal particles is fixed. After an oxidation potential is applied to the working electrode and metal ions are generated, a reduction potential is applied to a portion of the working electrode having a smaller area than the portion to which the oxidation potential was applied; metal is deposited on the surface of the portion to which the reduction potential was applied; current, voltage, or charge resulting from the deposited metal is measured; and metal-ion or analyte detection is carried out.
Provided are a measurement system, a rack loading and unloading unit, and a rack loading and unloading method with which limited space can be efficiently used to arrange racks. This measurement system (100) comprises measurement units (10), a conveyance unit (20), and rack loading and unloading units (30). Each measurement unit (10) measures a specimen housed in a specimen container. The conveyance unit (20) comprises: a first conveyance part (21) for conveying racks, which can hold a plurality of specimen containers in the long direction thereof, to the measurement units (10); and a second conveyance part (22) for conveying the racks from the measurement units. The rack loading and unloading units (30) can arrange a plurality of racks and are configured so as to be capable of shifting the arranged racks in the short direction thereof, unload the racks onto the first conveyance part (21) from one end thereof, and, from the other end thereof, load the racks conveyed by the second conveyance part (22).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
75.
CELL IMAGING DEVICE, CELL IMAGING METHOD, AND SAMPLE CELL
Provided are a cell imaging device and a cell imaging method that make it possible to shorten the imaging time for cells located inside a liquid sample, as compared to the prior art. In a cell imaging device 100, a urine sample containing cells is introduced into an interior space 11 of a sample cell 10, and while at least one of the sample cell 10 and an object lens 52 is being moved in a first direction, at least one of the sample cell 10 and the object lens 52 is moved in a second direction that is different than the first direction, and the cells included in the urine sample are imaged using an imaging unit 50 at a plurality of imaging positions.
The present invention reduces the time necessary for staining and makes an apparatus smaller. This smear preparation apparatus (100) is provided with: a staining tank (20) for storing a staining liquid (11) for immersing a plurality of glass slides (10) on which specimen are smeared; and a transfer unit (30) for holding and transferring the glass slides (10). The staining tank (20) includes a plurality of first holding parts (21) configured so as to hold the glass slides (10). The staining tank (20) is configured so as to immerse the plurality of glass slides (10) held by the plurality of first holding units (21) in the stored staining liquid (11). The transfer unit (30) is configured so as to insert and remove the glass slides (10) into and from the plurality of first holding units (21) of the staining tank (20) one slide at a time.
This smear sample preparation device is provided with: a housing part having a transport part for holding and transporting a slide glass, an insertion opening for insertion of the slide glass transported by the transport part, and feed opening into which a current of air is fed; and a blower part for directing a current of air through the feed opening to a slide glass housed within the housing part. The housing part is provided with a discharge opening for discharging the current of air fed therein from the blower part through the feed opening.
A specimen measurement device (10) is provided with: a processing unit (14) for sucking out a specimen within a specimen container (100) and measuring the specimen, a transfer unit (12) that is provided with a holding unit (12a) for holding the specimen container (100) and is for removing a specimen container (100) from a rack (200) capable of storing specimen containers (100) side-by-side in a plurality of storage positions and for transferring the specimen container (100) to the processing unit (14), and a detection unit (13) that is attached to the holding unit (12a) so as to be capable of moving integrally with the same and detects the presence of the specimen containers (100) in the storage positions (211-220).
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
This analyte measurement device 10 is provided with: a laser diode 16a for irradiating with a laser beam a measurement sample prepared from an analyte; a detection unit 120 for acquiring optical information from particles in the measurement sample irradiated with the laser beam; a drive circuit 13 for presenting a DC drive signal to the laser diode 16a; and a high-frequency conversion circuit 14 for generating a potential that repeatedly cycles through a high level and a low level in a prescribed cycle, whereby the drive signal outputted by the drive circuit 13 is guided in a prescribed cycle onto a second signal path 103 different from a first signal path 102 connected to the laser diode 16a, and the drive signal presented to the laser diode 16a is converted to high frequency.
In the present invention, when it is determined that a point plotted on a graph is positioned on a discrimination curve DC or above the discrimination curve DC, a decision unit determines that a specular reflection region is included in imaging data for a measurement surface. A second detection brightness and a second decrease rate are computed, after which a measurement item is assessed using the second decrease rate as an assessment index. When it is determined that a point plotted on a graph is positioned below the discrimination curve DC, the decision unit determines that a specular reflection region is not included in the imaging data for the measurement surface. A measurement item is assessed using a first decrease rate as the assessment index.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
81.
PARTICLE IMAGE-CAPTURING DEVICE AND PARTICLE IMAGE-CAPTURING METHOD
[Problem] Provided is a particle image-capturing device and a particle image-capturing method which enable a particle being imaged to be imaged with high quality while the processing speed of a measuring device is maintained. [Solution] A particle image-capturing device 10 is provided with: a flow path 100 for flowing a measurement sample containing a particle, the flow path 100 including a first flow path section 110, and a second flow path section 120 and a third flow path section 130 which are connected to downstream of the first flow path section 110; a particle detection unit 20 for detecting a particle flowing through the first flow path section 110; a particle sorting unit 30 capable of selectively adjusting the travel direction of the particle, which flows through the first flow path section 110, at least between the second flow path section 120 and the third flow path section 130 on the basis of the detection result provided by the particle detection unit 20; and a particle image-capturing unit 50 for imaging a particle flowing through the second flow path section 120.
REAGENT FOR DETECTING TARGET SUBSTANCE CONTAINING SUGAR CHAIN, DETECTION METHOD, CARRIER USED IN DETECTION OF TARGET SUBSTANCE CONTAINING SUGAR CHAIN, AND METHOD FOR MANUFACTURING SAID CARRIER
This invention pertains to a method for detecting a target substance, a reagent for detecting a target substance, a carrier, and a method for manufacturing said carrier that are useful in the detection of, for example, a sugar protein that contains a specific sugar chain.
The present invention pertains to a method for urine sample analysis, a reagent for urine sample analysis, and a reagent kit for urine sample analysis, which are for detecting at least casts and erythrocytes as physical components of urine.
The present invention pertains to a method for urine sample analysis, a reagent for urine sample analysis, and a reagent kit for urine sample analysis, which are for detecting at least casts and erythrocytes as solid components of urine.
The present invention pertains to a urine sample analysis method and a reagent kit for urine sample analysis, for detecting at least sperm and yeast-like organisms as formed elements in urine.
This test piece pickup mechanism for picking up test pieces for liquid sample analysis one by one from a test piece bottle is provided with a pickup head that sucks and holds each of the test pieces, and a motor for rotating the pickup head. The pickup head is provided with a suction port for sucking and holding each of the test pieces, and the motor is a hollow motor, and the hollow portion thereof is connected to the suction port.
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
87.
URINE SAMPLE ANALYSIS DEVICE AND URINE SAMPLE ANALYSIS METHOD
A sample analysis device (100) prepares a first measurement sample from a diluted solution (19u) having no hemolytic action on a urine sample and from a staining solution (18u) that stains membrane; and obtains a fluorescence signal by supplying the first measurement sample to a flow cell (51), irradiating laser light on the sample, and receiving fluorescent light emitted from the first measurement sample. In addition, the sample analysis device (100) prepares a second measurement sample from a diluted solution (19b) having a hemolytic action on the urine sample and from a staining solution (18b) that stains nuclei; and obtains a fluorescence signal by supplying the second measurement sample to the flow cell (51), irradiating laser light on the sample, and receiving fluorescent light emitted from the second measurement sample. Particles not having nucleic acid including red blood cells are detected on the basis of information about the fluorescence signal obtained from the first measurement sample and cells having nucleic acid including white blood cells are detected on the basis of information about the fluorescence signal obtained from the second measurement sample.
The present invention pertains to a pretreatment method for a sample for detecting an HBs antigen, which is a Hepatitis B virus surface antigen, and an HBs-antigen detection method which uses this method. In addition, the present invention pertains to a pretreatment reagent kit for detecting the HBs antigen.
Methods for efficient and high throughput emulsion-based nucleic amplification are provided. In some aspects, emulsion mixtures are provided that require extremely low input energy (e.g., the energy generated by pipetting) to form emulsions that are effective for nucleic acid amplification. Efficient formulations for breaking emulsions are likewise provided.
The present invention is a positioning tape for indicating an area in which micropores have been formed when a micropore formation device is brought into contact with the skin and micropores are formed in the skin by a microneedle of the micropore formation device. The positioning tape is provided with a support body having a positioning part for forming a step including a shape in which at least a portion corresponds to the shape of the contact part of the micropore formation device, and a mark part having an opening that corresponds to the area in which the micropores are formed. The step of the positioning part restricts movement of the micropore formation device in the direction of the skin surface when the contact part of the micropore formation device is brought into contact with the positioning tape in order to form micropores.
A non-invasive living body measurement device (1), provided with: a platform (21) for placing a finger (8) of the subject to be measured; a light emission device (3) equipped with a plurality of light emission blocks (311-316) disposed in a line so as to be arranged along the longitudinal direction of the finger (8) placed on the platform (21); a light amount adjustment part (5) for adjusting the amount of light from the light emission blocks (311-316) so that the amount of transmitted light transmitted through the finger (8) placed on the platform (21) is uniform along the longitudinal direction of the finger (8); an imaging part (4) for receiving transmitted light resulting from the light generated by the light emission blocks (311-316) transmitting through the finger (8) placed on the platform (21), and obtaining an image of the finger; and an information processing unit for processing the image obtained by the imaging part (4) and thereby detecting biological information about the subject.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
92.
SAMPLE PREPARATION DEVICE, CELL ANALYSIS DEVICE, AND FILTER MEMBER
[Problem] To provide a sample preparation device capable of generating with good efficiency a sample with a higher concentration of cells to be analyzed, a cell analysis device provided therewith, and a filter member. [Solution] The sample preparation device is provided with: a filter member having a filter for differentiating between cells to be analyzed in a sample and other cells; a first accommodation part and a second accommodation part coupled to each other via the filter; a third accommodation part capable of accommodating a sample; a communication port formed in the first accommodation part and used for allowing a sample to enter and exit the first accommodation part; a conduit in communication with the third accommodation part and the communication port; a negative pressure part for imparting a negative pressure inside the second accommodation part to thereby move the sample inside the third accommodation part to the filter via the conduit and the first accommodation part, and move components other than those to be analyzed to the second accommodation part via the filter; and a positive pressure part for imparting a positive pressure from the second accommodation part side to the filter on which cells to be analyzed are deposited.
C12M 1/00 - Apparatus for enzymology or microbiology
B01D 29/01 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ; Filtering elements therefor with flat filtering elements
C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
The present invention provides a method in which the methylation state of a CpG island in a promoter region of the ZNF304 gene and/or the ZNF264 gene in DNA extracted from a biosample from a subject is analyzed and information about colorectal cancer in said subject is obtained on the basis of the result of that analysis.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
94.
METHOD FOR OBTAINING INFORMATION ABOUT HEPATOCELLULAR CARCINOMA, AND MARKER AND KIT FOR OBTAINING INFORMATION ABOUT HEPATOCELLULAR CARCINOMA
The present invention provides a method in which the methylation state of CpG sites in a promoter region of at least one gene selected from among EFNB2, CCNJ, and KCTD12 in DNA extracted from a biosample from a subject is analyzed and information about a hepatocellular carcinoma in said subject is obtained on the basis of the analysis results.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
95.
METHOD FOR OBTAINING INFORMATION ABOUT ENDOMETRIAL CANCER, AND MARKER AND KIT FOR OBTAINING INFORMATION ABOUT ENDOMETRIAL CANCER
The present invention provides a method in which the methylation state of CpG sites in a promoter region of the F13A1 gene and/or the CHCHD5 gene in DNA extracted from a biosample from a subject is analyzed and information about endometrial cancer in said subject is obtained on the basis of the analysis results.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
96.
METHOD FOR OBTAINING INFORMATION ABOUT BRAIN TUMOR AND MARKER AND KIT FOR OBTAINING INFORMATION ABOUT BRAIN TUMOR
The present invention provides a method in which the methylation state of a CpG site in a promoter region of at least one gene selected from among CREM, VRK2, and MYL12A in DNA extracted from a biosample from a subject is analyzed and information about a brain tumor in said subject is obtained on the basis of the result of that analysis.
C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
97.
ANALYSIS SYSTEM, ANALYSIS DEVICE, MANAGEMENT DEVICE, AND COMPUTER PROGRAM
In order to enable the registration of measurement parameters to be grasped on the management side in case the measurement parameters are erroneously registered, an analysis system (1) comprises an analysis device (100) which analyzes a sample in accordance with measurement parameters set for a reagent to be used, and a management device (200) which is connected to the analysis device to be communicable therewith via a network. The analysis device (100) is provided with a processing unit (120), and a transmission unit (126) which transmits information to the management device (200). The processing unit (120) enables the execution of processing for accepting the registration of the measurement parameters, and when the measurement parameters have been registered, executes processing for transmitting transmission information including information indicating that the measurement parameters have been registered from the transmission unit (126) to the management device (200).
To provide a reagent receptacle for use in a biological sample analysis device which has high impact resistance in comparison with the prior art, and a method for manufacturing said reagent receptacle. A reagent receptacle for use in a biological sample analysis device is formed from a sheet member made from paper, and comprises a bottom face and a side wall face connecting with the bottom face. One edge side of a square-cylinder shaped cylinder body formed from the sheet member is folded, and the overlapped faces are adhered to form the bottom face, and in a specified region including the apex of the bottom face the overlapped faces are not adhered.
B65D 5/40 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper specially constructed to contain liquids
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
99.
METHOD FOR DETERMINING PRESENCE OR ABSENCE OF CANCER CELL DERIVED FROM HEPATOCELLULAR CARCINOMA, AND DETERMINATION MARKER AND KIT
The present invention relates to a method for analyzing the state of methylation of a CpG site occurring in a promoter region for at least one gene selected from ACTG1, EPHA4 and TSC22D1 that are contained in DNA extracted from a biological sample and determining the presence or absence of a cancer cell derived from hepatocellular carcinoma on the basis of the results of the analysis. The present invention also relates to a determination maker and a kit, both of which can be used in the method.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
100.
MOLECULE CAPABLE OF BINDING TO ADRENOCORTICOTROPIC HORMONE, AND USE THEREOF
The present invention relates to a molecule which can bind to adrenocorticotropic hormone (ACTH) with a high affinity. The present invention also relates to use of the above-mentioned molecule for detecting and/or purifying ACTH.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
patents
