Siemens Healthcare Diagnostics Inc.

United States of America

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G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor 59
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids 53
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations 53
G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor 51
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 47
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1.

DEVICE AND METHODS FOR ISOLATING MICROORGANISMS FROM BIOLOGICAL SAMPLES FOR DIAGNOSTIC ANALYSIS

      
Application Number US2023078305
Publication Number 2024/102596
Status In Force
Filing Date 2023-11-01
Publication Date 2024-05-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Ledden, David

Abstract

A method of isolating microorganisms present in a biological sample for diagnostic analysis, such as a diagnostic assay for sepsis. The method involves the use of filtration and acoustophoresis to substantially lyse any blood cells present in the biological sample and isolate any microorganisms present in the biological sample from the lysed cellular debris. Also disclosed are microfluidic devices, kits, and systems that can be utilized in the method.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
  • C12Q 1/06 - Quantitative determination
  • C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor

2.

METHOD AND DEVICE FOR DETERMINING ONSET OF SEPSIS IN EMERGENCY SET-UPS

      
Application Number US2023036346
Publication Number 2024/097153
Status In Force
Filing Date 2023-10-31
Publication Date 2024-05-10
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Gupta, Ankit
  • Chauhan, Ruchi

Abstract

A method (200) and a device (100) for determining onset of sepsis are provided. In one aspect, the method (200) includes receiving a medical dataset associated with the patient. Further, the method (200) includes determining if the plurality of medical parameters includes at least one sepsis specific parameter. Additionally, the method (200) includes determining a first output parameter if the plurality of medical parameters does not include at least one sepsis specific parameter. The method (200) also includes determining a second output parameter indicative of onset of sepsis in the patient if the plurality of medical parameters include at least one sepsis specific parameter, wherein the medical parameters associated with the patient are obtained for at least one time instance.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

3.

ACRIDINIUM COMPOUNDS WITH FUSED HETEROCYCLES

      
Application Number US2023076242
Publication Number 2024/081561
Status In Force
Filing Date 2023-10-06
Publication Date 2024-04-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Bhimireddy, Eswarreddy
  • Sharpe, David
  • Owens, Robert
  • Jiang, Qingping

Abstract

Chemiluminescent acridinium conjugates and compounds capable of forming conjugates are disclosed. These chemiluminescent acridinium conjugates may be used as chemiluminescent tracers in immunoassays for the quantification and identification of certain analytes.

IPC Classes  ?

4.

METHODS OF DETECTING BLOOD CLOTS/DEPOSITS ON BLOOD GAS ANALYZER SENSORS

      
Application Number US2023072224
Publication Number 2024/059402
Status In Force
Filing Date 2023-08-15
Publication Date 2024-03-21
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Zhang, Wei

Abstract

33) sensor. Kits and systems containing the electrochemical sensor modules are also disclosed, as well as methods of using the electrochemical sensor modules.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/483 - Physical analysis of biological material
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • G01N 33/487 - Physical analysis of biological material of liquid biological material

5.

IMPROVING SIGNAL TO NOISE IN IMMUNOASSAYS

      
Application Number US2023074184
Publication Number 2024/059707
Status In Force
Filing Date 2023-09-14
Publication Date 2024-03-21
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Mitra, Nivedita
  • V M, Ramya
  • Azhar, Mohiudeen
  • Jiang, Qingping
  • Chakraborty, Ishita
  • Sharpe, David

Abstract

The present disclosure includes certain steps in immunoassays, such as immunoassays based on chemiluminescence, which increase assay sensitivity as based on a variety of metrics including increasing signal to noise and decreasing limits of detection. One strategy for these enhancements involves movement, and potential sequestration, of solid phases in one triggering reagent prior to addition of a second triggering reagent for chemiluminescence..

IPC Classes  ?

  • B03C 1/02 - Magnetic separation acting directly on the substance being separated
  • B03C 1/28 - Magnetic plugs and dipsticks
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

6.

SELF-TUNING BUBBLE DETECTOR ASSEMBLIES, CALIBRATION METHODS, AND COMPUTER PROGRAM PRODUCTS FOR DIAGNOSTIC ANALYZERS

      
Application Number US2023074199
Publication Number 2024/059716
Status In Force
Filing Date 2023-09-14
Publication Date 2024-03-21
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Rosenfeld, Ari

Abstract

A self-tuning optical bubble detector assembly for diagnostic analyzers. The bubble detector assembly has a light emitter operated at a plurality of inputs (i.e., generating a plurality of light intensities) for dry supply line tubing (i.e., having no liquid) and for a wet supply line tubing (i.e., having liquid therein). A plurality of outputs representing light detected through the dry supply line tubing and the wet supply line tubing are generated. Based on the received outputs, a final calibrated setting (e.g., a % duty setting or an I_LED) and a threshold are determined at which to accurately and repeatedly determine if the supply line tubing has liquid or air therein. Further provided are methods of self-tuning an optical bubble detector for diagnostic analyzers and computer program products, as are other aspects.

IPC Classes  ?

  • G01N 21/85 - Investigating moving fluids or granular solids
  • G01N 15/14 - Electro-optical investigation

7.

SYSTEMS AND METHODS FOR DETERMINING TEST RESULT ACCURACIES IN DIAGNOSTIC LABORABORY SYSTEMS

      
Application Number US2023073611
Publication Number 2024/054890
Status In Force
Filing Date 2023-09-07
Publication Date 2024-03-14
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Singh, Vivek
  • Prasad, Rayal
  • Chang, Yao-Jen
  • Narasimhamurthy, Venkatesh
  • Edwards, Mark
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A method of determining the accuracy of a test performed by a diagnostic laboratory system includes obtaining one or more first measurements during a first operation of the test performed by the diagnostic laboratory system. One or more second measurements are obtained during a second operation of the test performed by the diagnostic laboratory system. The first measurements and the second measurements are collectively analyzed using a trained model that calculates an uncertainty score for the test based on learned correlations between the first operation and the second operation. The uncertainty score may be used to determine whether the test results can be relied upon or whether the test should be rerun. Other methods and systems are disclosed.

IPC Classes  ?

  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • G06N 3/02 - Neural networks
  • G06N 3/08 - Learning methods
  • G06N 20/00 - Machine learning
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G06N 5/00 - Computing arrangements using knowledge-based models
  • G06V 10/426 - Graphical representations
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

8.

DEVICES AND METHODS FOR TRAINING SAMPLE CONTAINER IDENTIFICATION NETWORKS IN DIAGNOSTIC LABORATORY SYSTEMS

      
Application Number US2023073616
Publication Number 2024/054894
Status In Force
Filing Date 2023-09-07
Publication Date 2024-03-14
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Bektaoui, Walid
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Singh, Vivek
  • Kapoor, Ankur

Abstract

A method of training a sample container identification network of a diagnostic laboratory system includes obtaining a plurality of data subsets, wherein each data subset is smaller than a full training data set used to train the sample container identification network and includes a plurality of images of one or more sample containers. The sample container identification network is trained on each of the plurality of data subsets to generate a plurality of trained sample container identification networks. Each of the trained sample container identification networks are testing using testing data that includes test images of sample containers, wherein the testing includes identifying the sample containers in the test images. A core data set is selected from one of the plurality of data subsets based on the testing, the core data set for use in training a deployed sample container identification network. Other methods and systems are disclosed.

IPC Classes  ?

  • G06N 5/00 - Computing arrangements using knowledge-based models
  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • G06N 3/02 - Neural networks
  • G06N 3/08 - Learning methods
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
  • G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
  • G06V 10/84 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using probabilistic graphical models from image or video features, e.g. Markov models or Bayesian networks

9.

SAMPLE CONTAMINATION DETECTION APPARATUS AND METHODS

      
Application Number US2023072132
Publication Number 2024/054739
Status In Force
Filing Date 2023-08-14
Publication Date 2024-03-14
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Kampfrath, Thomas
  • Snyder, Jennifer

Abstract

Disclosed is a blood contamination detection apparatus. The blood contamination detection apparatus comprises a computer-based contamination determining module configured to receive: one or more baseline quantified test results on an uncontaminated blood sample obtained from a patient; one or more quantified test results for one or more analytes of a blood sample or a blood component; and data input on a type of IV fluid infusion that the patient has received that is able to affect the one or more quantified test results. The computer-based contamination determining module comprises a contamination determining routine executable on a computer and configured to compare differences between the one or more baseline quantified test results and the one or more quantified test results against preset threshold difference values and/or directions and provide a contamination output. Sample contamination detection method are provided, as are other aspects.

IPC Classes  ?

  • G01N 21/88 - Investigating the presence of flaws, defects or contamination
  • G01N 15/05 - Investigating sedimentation of particle suspensions in blood
  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
  • C12Q 1/06 - Quantitative determination
  • G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

10.

STATE ESTIMATION USING SPARSE HALL SENSOR-BASED SENSING

      
Application Number US2023072520
Publication Number 2024/044517
Status In Force
Filing Date 2023-08-18
Publication Date 2024-02-29
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Ramakrishnan, Narayanan
  • Edwards, Mark

Abstract

A system and method of tracking vessel movers within a liquid handler system using sparse sensor assemblies. The method includes mapping received sensor signals to pre-characterized functions and determining the positions of the vessel movers with respect to a single sensor from the sensor assembly accordingly. The sensors in the sparse sensor assembly can be positioned to have no or minimal overlap between their sensing ranges.

IPC Classes  ?

  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01R 33/07 - Hall-effect devices
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

11.

HYBRIDIZED CONTROL ARCHITECTURE FOR VESSEL MOVER MOVEMENT CONTROL

      
Application Number US2023072521
Publication Number 2024/044518
Status In Force
Filing Date 2023-08-18
Publication Date 2024-02-29
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Ramakrishnan, Narayanan
  • Edwards, Mark

Abstract

A system and method for a hybridized control architecture for a liquid handler system. The hybridized control system can control the movement of the vessel movers of the liquid handler system using a hybridized movement control approach that incorporates both position, velocity and current-based control outputs. The control system can further dynamically control the relative degree to which velocity or position-based control is applied to the vessel movers based on the vessel movers' relative positions along the track system.

IPC Classes  ?

  • G01N 35/12 -
  • B65G 43/08 - Control devices operated by article or material being fed, conveyed, or discharged
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

12.

METHOD OF DETECTING AN OBSTRUCTION IN A FLUID ANALYZER

      
Application Number US2023072211
Publication Number 2024/040052
Status In Force
Filing Date 2023-08-15
Publication Date 2024-02-22
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Zhang, Wei

Abstract

Methods and systems for detecting an obstruction on a sensor of a fluid analyzer, including a method comprising causing a first calibration fluid to contact the sensor to generate signals indicative of a first electric potential of the first calibration fluid; causing a second calibration fluid to contact the sensor to generate signals indicative of a second electric potential of the second calibration fluid; storing a first response slope; causing the first calibration fluid to contact the sensor to generate signals indicative of a third electric potential of the first calibration fluid; causing the second calibration fluid to contact the sensor to generate signals indicative of a fourth electric potential of the second calibration fluid; storing a second response slope; and storing data indicative of an obstruction on the sensor in response to a difference between the first response slope and the second response slope being beyond a threshold.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
  • G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light

13.

TRAY INSERT FOR USE IN SAMPLE ANALYSIS APPARATUS

      
Application Number US2023071478
Publication Number 2024/036066
Status In Force
Filing Date 2023-08-02
Publication Date 2024-02-15
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Arfan, Mohammed
  • Bhattacharya, Sudipa
  • Savarni K R, Vaishnav Ram

Abstract

A tray insert for use with an apparatus configured to analyze a sample is disclosed. The tray insert includes a first surface comprising an elongated channel adapted to receive a reagent strip for sample analysis. Further, the insert includes a second surface, wherein the second surface is in a direction opposite to the first surface. Additionally, the insert includes a hollow enclosure between the first surface and the second surface, wherein the elongated channel on the first surface comprises a plurality of slots and wherein the slots comprise an opening on each end, wherein the opening enters the hollow enclosure.

IPC Classes  ?

  • C12M 1/14 - Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/28 - Preparing specimens for investigation

14.

EXTRACTION METHOD FOR NUCLEIC ACIDS

      
Application Number US2023028644
Publication Number 2024/025921
Status In Force
Filing Date 2023-07-26
Publication Date 2024-02-01
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chakraborty, Ishita
  • Khandige, Divya
  • Mitra, Nivedita
  • Vm, Ramya

Abstract

A method (100) of extracting nucleic acids is disclosed. The method includes receiving a sample containing nucleic acids to be extracted. The method (100) includes lysing cells in the sample to release the nucleic acids. The method (100) also includes introducing the released nucleic acids to a substrate, wherein the nucleic acids bind to the substrate. The method (100) includes washing the substrate bound to the nucleic acids and eluting the nucleic acids from the substrate. The introducing of the released nucleic acids to the substrate, the washing of the substrate bound to the nucleic acids, and the eluting of the nucleic acids are performed in a pipette tip.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

15.

DYNAMIC ROUTING ALGORITHMS FOR MODULAR ANALYZER SYSTEMS

      
Application Number US2023028609
Publication Number 2024/025900
Status In Force
Filing Date 2023-07-25
Publication Date 2024-02-01
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Prasad, Rayal
  • Chang, Yao-Jen
  • Kapoor, Ankur
  • Edwards, Mark

Abstract

Systems and methods for dynamic route planning for use with modular liquid handler systems. A route planning algorithm can be utilized to plan routes for the vessel movers of the liquid handler systems in a dynamic manner, without the need for hardcoded routes, so that a route planning system can efficiently transport samples between modules of the liquid handler systems while minimizing risks of collisions and jams. The route planning algorithm can be configured to receive a representation of the liquid handler system configuration and plan routes for the vessel movers accordingly.

IPC Classes  ?

  • G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
  • G05B 15/02 - Systems controlled by a computer electric
  • G06N 20/00 - Machine learning

16.

ANALYZER HAVING A TRANSPARENT SHIELD FOR PROTECTING AN IMAGING SYSTEM

      
Application Number US2023070092
Publication Number 2024/020305
Status In Force
Filing Date 2023-07-13
Publication Date 2024-01-25
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Deshpande, Manish
  • Orton, Emma

Abstract

A method of receiving an image of a test device through a transparent shield not associated with an imaging system, wherein the transparent shield is positioned within a housing of a reagent analyzer; comparing pixel data of the received image of the test device through the transparent shield to determine a degree of occlusion of the transparent shield; determining whether the degree of occlusion exceeds a baseline value indicative of potential occlusion; and responsive to the degree of occlusion exceeding the baseline value, causing an action selected from a group consisting of: initiating an alert in a form perceivable by a human; storing data indicative of the degree of occlusion detected within the image exceeding the baseline value; initiating a cleaning process configured to clean the transparent shield; and replacing the transparent shield with a replacement transparent shield having a degree of occlusion less than the baseline value.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/84 - Systems specially adapted for particular applications
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

17.

SCALABLE DEPLOYMENT OF ONTOLOGY-BASED DECISION TREES FOR CLINICAL DECISION SUPPORT AND AUTOMATED CLINICAL WORKFLOWS

      
Application Number US2023021148
Publication Number 2024/015135
Status In Force
Filing Date 2023-05-05
Publication Date 2024-01-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Ullaskrishnan, Poikavila
  • Krumtünger, Ralf
  • Liliac, Teodora-Vanessa
  • Micu, Larisa
  • Schmuecking, Ingo
  • Sharma, Puneet

Abstract

Systems and methods for determining an evaluation of one or more patients is provided. User input for evaluating one or more patients is received. A commit bundle is retrieved from a commit database. An evaluation of the one or more patients is determined based on the user input using a medical ontology configured with the retrieved commit bundle. The medical ontology is separate from the commit database. Results of the evaluation of the one or more patients are output.

IPC Classes  ?

  • G06N 5/01 - Dynamic search techniques; Heuristics; Dynamic trees; Branch-and-bound
  • G06N 5/022 - Knowledge engineering; Knowledge acquisition
  • G06N 5/025 - Extracting rules from data
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

18.

DEVICES AND METHODS FOR TRAINING SAMPLE CHARACTERIZATION ALGORITHMS IN DIAGNOSTIC LABORATORY SYSTEMS

      
Application Number US2023027679
Publication Number 2024/015534
Status In Force
Filing Date 2023-07-13
Publication Date 2024-01-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chang, Yao-Jen
  • Shenoy, Nikhil
  • Jangale, Ramkrishna
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A method of updating training of an annotation generator of a diagnostic laboratory system includes providing an imaging device in the diagnostic laboratory system, wherein the imaging device is controllably movable within the diagnostic laboratory system; capturing a first image within the diagnostic laboratory system using the imaging device, the first image captured with at least one imaging condition; performing an annotation of the first image using the annotation generator to generate a first annotated image; and updating training of the annotation generator using the first annotated image. Other methods and systems are disclosed.

IPC Classes  ?

19.

ACOUSTOPHORETIC ANALYZATION DEVICES AND METHODS

      
Application Number US2022078504
Publication Number 2024/005867
Status In Force
Filing Date 2022-10-21
Publication Date 2024-01-04
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Jasperse, Jeffrey
  • Paulicka, Peter
  • Palombo, Michael
  • Seliger, Ramona

Abstract

Fluid analyzation devices, methods, and systems are disclosed including an analyzation device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an piezo transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the piezo transducer configured to emit ultrasonic acoustic waves having a first frequency, a second frequency, and a third frequency into and/or to a blood sample within the microchannel, the first frequency configured to begin separation of red blood cells and plasma in the blood sample, the second frequency configured to complete separation of the red blood cells and plasma, and the third frequency configured to rupture cell walls of the blood cells producing a lysed blood sample.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 1/28 - Preparing specimens for investigation
  • C12N 1/06 - Lysis of microorganisms

20.

ACOUSTOPHORESIS DEVICES HAVING CONDUCTIVE ELECTRODES AND METHODS

      
Application Number US2022077832
Publication Number 2023/244275
Status In Force
Filing Date 2022-10-10
Publication Date 2023-12-21
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Jasperse, Jeffrey
  • Paulicka, Peter
  • Palombo, Michael
  • Seliger, Ramona
  • Benson, Paul

Abstract

An acoustophoresis device having a sample vessel and a piezo transducer is described. The sample vessel has an outer surface, a microchannel within confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel, such that a blood sample is insertable through the first port into the microchannel. The sample vessel has conductive traces on the outer surface. The piezo transducer is bonded to the outer surface of the sample vessel to form a monolithic structure. The piezo transducer contacts at least one of the conductive traces, the piezo transducer is configured to generate ultrasonic waves inside a sample in the microchannel. The piezo transducer has an excitation signal input and response signal output electrically connected to the at least one of the conductive traces.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C12M 1/00 - Apparatus for enzymology or microbiology
  • G01N 1/28 - Preparing specimens for investigation
  • C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

21.

DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC ASSAY DEVICE

      
Application Number US2023068454
Publication Number 2023/245072
Status In Force
Filing Date 2023-06-14
Publication Date 2023-12-21
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Cox, Janine
  • Ledden, David
  • Jasperse, Jeffrey

Abstract

Chromatographic assay devices for detecting the presence of free hemoglobin in a liquid biological sample are disclosed. The device comprises a sample application pad and a chromatographic detection pad, wherein the sample application pad is formed of two layers of material. Medical diagnostics devices for use with the chromatographic assay devices are also disclosed, as well as kits and methods of using the chromatographic assay device and/or medical diagnostics device.

IPC Classes  ?

  • G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
  • G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
  • G01N 33/72 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. hemoglobin, bilirubin

22.

METHODS AND KITS FOR DETERMINING ANTIBIOTIC SUSCEPTIBILITY

      
Application Number US2023067667
Publication Number 2023/235732
Status In Force
Filing Date 2023-05-31
Publication Date 2023-12-07
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Mitra, Nivedita
  • V M, Ramya

Abstract

The present disclosure relates to a method of determining antibiotic susceptibility of a micro-organism in a sample, the method including: receiving the sample containing the micro-organisms; incubating at least one first portion of the sample with at least one antibiotic and at least one second portion of the sample with no antibiotic; extracting nucleic acid from the at least one first portion of the sample and the at least one second portion of the sample, wherein the nucleic acid is associated with the micro-organisms present in the sample; amplifying the extracted nucleic acid from the at least one first portion and the at least one second portion of the sample; and obtaining the antibiotic susceptibility information associated with the micro-organism from the amplified nucleic acid from the at least one first portion and the at least one second portion of the sample.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

23.

METHODS AND APPARATUS FOR DETERMINING A VIEWPOINT FOR INSPECTING A SAMPLE WITHIN A SAMPLE CONTAINER

      
Application Number US2023023175
Publication Number 2023/230024
Status In Force
Filing Date 2023-05-23
Publication Date 2023-11-30
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Shenoy, Nikhil
  • Chang, Yao-Jen
  • Kapoor, Ankur
  • Pollack, Benjamin S.

Abstract

In some embodiments, a method of determining a viewpoint for optically inspecting a sample within a sample container is provided that includes ( a ) employing a sensor to capture image data of a sample container including a sample, wherein a portion of the sample container includes a label having first and second ends; (b) rotating at lea st one of the sample container and the sensor about a central axis of the sample container so that the sensor capture s image data including at least the first and second ends of the label; ( c ) employing the captured image data to generate an unwrapped image of the sample container; (d) processing the unwrapped image to characterize the label and produce label characterization information; and ( e ) employing the label characterization information to identify a viewpoint through which to optically inspect the sample within the sample container. Numerous other aspects are provided.

IPC Classes  ?

  • G06T 7/174 - Segmentation; Edge detection involving the use of two or more images
  • G06T 7/12 - Edge-based segmentation
  • H04N 19/167 - Position within a video image, e.g. region of interest [ROI]
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

24.

SAMPLE HANDLERS OF DIAGNOSTIC LABORATORY ANALYZERS AND METHODS OF USE

      
Application Number US2023022596
Publication Number 2023/225123
Status In Force
Filing Date 2023-05-17
Publication Date 2023-11-23
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chang, Yao-Jen
  • Pandey, Abhineet Kumar
  • Shenoy, Nikhil
  • Jangale, Ramkrishna
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A sample handler of a diagnostic laboratory system includes a plurality of holding locations configured to receive sample containers. An imaging device is movable within the sample handler and is configured to capture images of the holding locations and sample containers received therein. A controller is configured to generate instructions that cause the imaging device to move within the sample handler and capture images. A classification algorithm is implemented in computer code, and includes a trained model configured to classify objects in the captured images. Other sample handlers and methods of handling sample containers are disclosed.

IPC Classes  ?

  • G01N 1/00 - Sampling; Preparing specimens for investigation
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

25.

MULTI-LAYER SOFTWARE ARCHITECTURE FOR OPERATING DIAGNOSTIC LABORATORY SYSTEMS

      
Application Number US2023020984
Publication Number 2023/215469
Status In Force
Filing Date 2023-05-04
Publication Date 2023-11-09
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Kirchberg, Klaus
  • Prasad, Rayal
  • Kapoor, Ankur

Abstract

A diagnostic laboratory system includes one or more instruments and a transport system configured to transport sample containers to and from the one or more instruments, wherein each of the sample containers contains a biological sample. A computer is configured to execute a program to control operation of the diagnostic laboratory system. The program has an architecture comprising a plurality of individually replaceable software modules, wherein one or more software modules identify at least one test or plan at least one phase thereof to be performed on the biological sample. Another software module generates instructions to cause one or more of the sample containers to move to or from the one or more instruments in accordance with the at least one test or the at least one phase thereof. Methods of operating a diagnostic laboratory system are also disclosed.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • B65G 47/52 - Devices for transferring articles or materials between conveyors, i.e. discharging or feeding devices
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

26.

DOCKING ASSEMBLIES, INTERFACE CLIPS, ADAPTERS, POINT-OF-CARE ASSEMBLIES, AND OPERATING METHODS THEREOF

      
Application Number US2023018699
Publication Number 2023/211703
Status In Force
Filing Date 2023-04-14
Publication Date 2023-11-02
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chura, William
  • Milesky, Lawrence

Abstract

A docking assembly for a point-of-care analyzer. The docking assembly comprises an adapter and interface clip. Adapter includes an adapter body attachable to the point-of-care analyzer, the adapter body having an opening and adapter electrical connector. The interface clip is receivable in the opening and includes a clip body and clip electrical connector. Clip electrical connector includes a clip interface member electrically interfaceable with a data and power port of a handheld computing device, and a clip data and power member configured to electrically connect with an adapter interface member. The adapter electrical connector and the clip electrical connector are configured to facilitate charging of the handheld computing device through an electrical connection between at least one adapter charging contact and the clip interface member. Adapters, interface clips, point-of-care assemblies using the docking assemblies, and methods of operating such point-of-care assemblies are provided, as are other aspects.

IPC Classes  ?

  • A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/483 - Physical analysis of biological material
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
  • G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
  • G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
  • H04W 88/02 - Terminal devices

27.

BIOMARKERS FOR IDIOPATHIC PULMONARY FIBROSIS AND METHODS OF PRODUCING AND USING SAME

      
Application Number US2023065978
Publication Number 2023/205712
Status In Force
Filing Date 2023-04-19
Publication Date 2023-10-26
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Beard, Andrew
  • Green, Chris
  • Kronmüller, Sebastian

Abstract

Methods for determining the presence, severity, and/or predisposition of Idiopathic Pulmonary Fibrosis (IPF) in an individual are disclosed. The methods utilize at least one diagnostic marker of a dynamic process of extracellular matrix synthesis and/or extracellular matrix degradation from said sample. The at least one diagnostic marker may be selected from the group consisting of tissue metallopeptidase inhibitor 1 (TIMP1), hyaluronan (HA), and/or Procollagen Type III N-terminal propeptide (PIIINP).

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

28.

QUANTITATION OF ALKYLPHENOL ETHOXYLATE COMPOUNDS IN AQUEOUS SAMPLES

      
Application Number US2023019163
Publication Number 2023/205281
Status In Force
Filing Date 2023-04-19
Publication Date 2023-10-26
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Malewicz, Andrew

Abstract

A method for determining an amount of alkylphenol ethoxylate compounds in an aqueous sample is provided. The aqueous sample is subjected to an extraction technique to produce a purified sample, the purified sample is subjected to a chemical cleavage technique to convert alkylphenol ethoxylate compounds in the purified sample to their corresponding alkylphenol compounds and produce a cleaved sample. The cleaved sample is subjected to a liquid chromatography technique to obtain a fraction enriched in alkylphenol compounds from the cleaved sample. The fraction enriched in alkylphenol compounds is ionized under conditions suitable to generate fragment ions detectable by mass spectrometry. The amount of the fragment ions is determined using mass spectrometry, and the amount of the fragment ions is related to the amount of alkylphenol ethoxylate compounds in the aqueous sample.

IPC Classes  ?

29.

CREATININE LATERAL FLOW ASSAY DEVICES AND METHODS OF PRODUCTION AND USE THEREOF

      
Application Number US2023018015
Publication Number 2023/200703
Status In Force
Filing Date 2023-04-10
Publication Date 2023-10-19
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Kauffmann, Aaron
  • Mayfield, Jeffrey

Abstract

Lateral flow assay devices and kits for use in the detection of creatinine and in the detection of hemolysis in a biological fluid sample are disclosed. Methods of making and using the lateral flow assay devices and kits are also disclosed.

IPC Classes  ?

  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/70 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

30.

INCORPORATING FUNCTIONAL UNITS INTO MODULES OF AUTOMATED DIAGNOSTIC ANALYSIS SYSTEMS TO INCREASE FUNCTIONALITY THEREOF

      
Application Number US2023064745
Publication Number 2023/183789
Status In Force
Filing Date 2023-03-21
Publication Date 2023-09-28
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Prasad, Rayal
  • Chang, Yao-Jen
  • Kapoor, Ankur
  • Pollack, Benjamin S.

Abstract

An automated diagnostic analysis system includes a plurality of modules for processing and analyzing biological samples, a sample transport system for transporting sample containers to and from each of the modules, and a system controller for workflow planning and execution of sample analyses. To increase functionality of the automated diagnostic analysis system without increasing the floor space of the system, one or more of the modules may be configured to receive one or more functional units each operative to perform an additional action in connection with the sample analyses. The functional unit does not require separate access to the sample transport system, and the system controller is configured to dynamically include the functional unit in the workflow planning and execution of the sample analyses. Methods of operating an automated diagnostic analysis system are also provided, as are other aspects.

IPC Classes  ?

  • B01L 3/02 - Burettes; Pipettes
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

31.

AUTOMATION TRACK CONFIGURATIONS FOR MITIGATING SPILLS AND CONTAMINATION

      
Application Number US2023064742
Publication Number 2023/183787
Status In Force
Filing Date 2023-03-21
Publication Date 2023-09-28
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Ramakrishnan, Narayanan

Abstract

Systems and methods for passively redirecting liquid contaminants from the active region of riding surfaces of track systems for liquid handler systems, including surface energy gradient, channels, and roughness gradients. The described techniques redirect liquids in a passive manner, without requiring any additional electromechanical components or active control systems that would draw additional power and require additional layers of control architecture to manage.

IPC Classes  ?

  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • B65G 54/02 - Non-mechanical conveyors not otherwise provided for electrostatic, electric, or magnetic
  • G01N 21/13 - Moving of cuvettes or solid samples to or from the investigating station

32.

CALIBRATION TARGET, FOURIER PTYCHOGRAPHIC IMAGING SYSTEM AND METHOD FOR CALIBRATING A FOURIER PTYCHOGRAPHIC IMAGING SYSTEM

      
Application Number IB2023052233
Publication Number 2023/175452
Status In Force
Filing Date 2023-03-09
Publication Date 2023-09-21
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Engel, Thomas

Abstract

The invention relates to a calibration target (1) for a Fourier ptychographic imaging system (100), comprising at least a first plane (2) and a second plane (4), wherein the first plane (2) and the second plane (4) are parallel to each other and comprise a predefined distance (d, 2a) between each other, wherein the first plane (2) comprises a first calibration structure (22) and the second plane (4) comprises a second calibration structure (24), wherein the first calibration structure (22) is configured to be suitable for centering itself in relation to an optical component (14) and/or a ccaammeerraa (12) of the Fourier ptychographic imaging system (100), and wherein the second calibration structure (24) is configured to be suitable for determining, directly or in projection onto the first plane (2), a position of at least one characteristic or predetermined feature of the first calibration structure (22).

IPC Classes  ?

  • G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

33.

DEVICE, APPARATUS AND METHOD FOR DETECTING NUCLEIC ACIDS

      
Application Number US2023063989
Publication Number 2023/172984
Status In Force
Filing Date 2023-03-08
Publication Date 2023-09-14
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • V M, Ramya
  • Khandige, Divya
  • Mitra, Nivedita

Abstract

The present disclosure refers to a homogeneous method, apparatus and device for detection of target nucleic acids in a sample. In one aspect, the device includes a magnetic bead. Further, the device includes one or more oligonucleotides bound to the magnetic bead. Additionally, the device includes at least one reporter molecule linked to the one or more oligonucleotides.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

34.

LIPOSOME-CONTAINING DIAGNOSTIC REAGENTS AND METHODS OF PRODUCTION AND USE THEREOF

      
Application Number US2023062773
Publication Number 2023/172812
Status In Force
Filing Date 2023-02-16
Publication Date 2023-09-14
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Lee, Huey
  • Vitzthum, Frank
  • Son, Michelle
  • Halik, Luboslav
  • Bedzyk, William
  • Sommer, Michael

Abstract

Diagnostic immunoassay reagent compositions are disclosed that include liposomes having analyte-specific binding element(s) associated therewith. In particular, the analyte-specific binding element(s) includes a transmembrane domain that anchors the element(s) in the lipid bilayer of the liposome; the analyte-specific binding element(s) further includes an extracellular/extramembrane domain that is exposed on the outer surface of the liposome and that comprises a domain that specifically binds to the target analyte. Also disclosed are kits, devices, and systems that contain the diagnostic immunoassay reagent compositions, as well as methods of producing and using the diagnostic immunoassay reagent compositions.

IPC Classes  ?

  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
  • G01N 33/533 - Production of labelled immunochemicals with fluorescent label
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

35.

INTEGRATED CENTRALIZED AND DECENTRALIZED OPERATION OF AUTOMATED DIAGNOSTIC ANALYSIS SYSTEMS AND METHODS THEREOF

      
Application Number US2023063624
Publication Number 2023/168368
Status In Force
Filing Date 2023-03-02
Publication Date 2023-09-07
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Prasad, Rayal
  • Mailhe, Boris
  • Kapoor, Ankur

Abstract

An automated diagnostic analysis system includes a system controller for system-wide workflow planning and execution of sample analyses and also includes decentralized processing capabilities (e.g., one or more second controllers) for determining a work-around, where possible, to a detected fault affecting an analysis of a particular sample. The system controller communicates with system components via a first communication channel, while the second controller communicates with a subset of the system components via a second communication channel. Where a work-around for a detected fault cannot be determined by the second controller, the detected fault is communicated to the system controller for resolution. Methods of operating an automated diagnostic analysis system are also provided, as are other aspects.

IPC Classes  ?

  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

36.

DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF UPDATING

      
Application Number US2023063613
Publication Number 2023/168359
Status In Force
Filing Date 2023-03-02
Publication Date 2023-09-07
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Narasimhamurthy, Venkatesh
  • Singh, Vivek
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur
  • Prasad, Rayal

Abstract

Diagnostic laboratory systems, methods of operating diagnostic laboratory systems, and methods of updating diagnostic laboratory systems are disclosed. A method of operating a diagnostic laboratory system includes identifying data in the system as identified data; identifying change in a data distribution of the identified data; aggregating data instances pertaining to the change in the data distribution; selecting a subset of the aggregated data to update a processing algorithm in the system; and updating the processing algorithm using the subset of the aggregated data. Other systems and methods are disclosed.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G06N 20/00 - Machine learning
  • G06T 7/00 - Image analysis
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

37.

DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF IMAGING TUBE ASSEMBLIES

      
Application Number US2023063622
Publication Number 2023/168366
Status In Force
Filing Date 2023-03-02
Publication Date 2023-09-07
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chang, Yao-Jen
  • Singh, Vivek
  • Mailhe, Boris
  • Pollack, Benjamin, S.
  • Kapoor, Ankur

Abstract

A method of synthesizing an image of a tube assembly includes capturing an image of the tube assembly, wherein the capturing generates a captured image. The captured image is decomposed into a plurality of features in latent space using a trained image decomposition model. One or more of the features in the latent space is manipulated into one or more manipulated features. A synthesized tube assembly image is generated with at least one of the manipulated features using a trained image composition model. Other methods and systems are disclosed.

IPC Classes  ?

  • G06V 10/74 - Image or video pattern matching; Proximity measures in feature spaces
  • G06T 7/40 - Analysis of texture
  • G06T 7/50 - Depth or shape recovery
  • G06T 7/60 - Analysis of geometric attributes
  • G06T 7/90 - Determination of colour characteristics

38.

SYSTEM AND METHOD FOR DISEASE PREDICTION

      
Application Number US2023063091
Publication Number 2023/164525
Status In Force
Filing Date 2023-02-23
Publication Date 2023-08-31
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Mitra, Nivedita
  • Gupta, Kratika
  • Chaves, Fernando
  • Gibbs, Graham
  • Jones, Val

Abstract

A system (100) and a method (200) for predicting presence of a disease in a subject is disclosed. In one aspect, the system (100) includes one or more processing units (101), a medical database (112) coupled to the one or more processing units (101), and a disease prediction module (110). The module (110) is configured to receive a plurality of parameters associated with the subject. Additionally, the module (110) is configured to determine a threshold for sensitivity and/or specificity associated with a trained machine learning model. Further, the module (110) is configured to predict using the trained machine learning model the presence of the disease in the subject based on the desired sensitivity and specificity and the plurality of parameters associated with the subject and output the prediction on an output unit (105).

IPC Classes  ?

  • G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • G06N 20/00 - Machine learning

39.

PATIENT-CENTRIC LOAD PLANNING SYSTEM AND METHOD

      
Application Number US2023061131
Publication Number 2023/150440
Status In Force
Filing Date 2023-01-24
Publication Date 2023-08-10
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Zhang, Yue

Abstract

A method of patient-centric load planning for a diagnostic laboratory having a plurality of instruments includes receiving a list of patient samples, a list of requested tests to be performed for each of the patient samples, and patient-centric information for the patient providing each patient sample. The received data is used to determine a load plan for the instruments, the load plan including a menu of selected tests assigned to each instrument and an ordering of patient samples according to a priority score based on at least a portion of the electronic health record (EHR) of the patient providing the patient sample. A system for patient-centric load planning includes a plurality of instruments controlled by a system controller and computer server to formulate and execute the load plan.

IPC Classes  ?

  • G06Q 10/00 - Administration; Management
  • G06Q 10/06 - Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
  • G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
  • G06Q 10/0637 - Strategic management or analysis, e.g. setting a goal or target of an organisation; Planning actions based on goals; Analysis or evaluation of effectiveness of goals

40.

SEALING SYSTEM BETWEEN A MANIFOLD AND A LIQUID CONTAINER

      
Application Number US2023061913
Publication Number 2023/150664
Status In Force
Filing Date 2023-02-03
Publication Date 2023-08-10
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Daume, Dominik Andreas
  • Bäcker, Jan-Peter
  • Otto, Ralf

Abstract

A sealing system is provided that includes a liquid container configured to hold a liquid. The liquid container defines an opening having an inner circumferential sealing surface surrounding the opening, a manifold through which liquid is supplied to and/or removed from the liquid container. The manifold includes a sealing protrusion having an outer circumferential sealing surface, which is curved along a longitudinal axis. In a connected state, the manifold is located on the opening to supply liquid to, or to remove liquid from, the liquid container. The sealing protrusion extends into the opening, and the outer circumferential sealing surface contacts the inner circumferential sealing surface to form a seal between the manifold and the liquid container. In an unconnected state, a circumferential length of the outer circumferential sealing surface is larger than a circumferential length of the inner circumferential sealing surface.

IPC Classes  ?

  • F17C 1/00 - Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge
  • F17C 1/04 - Protecting sheatings
  • F17C 1/16 - Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge constructed of plastics materials
  • F17C 13/08 - Mounting arrangements for vessels
  • F16J 12/00 - Pressure vessels in general
  • F17C 1/02 - Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge involving reinforcing arrangements
  • F17C 1/08 - Integral reinforcements, e.g. ribs
  • F17C 13/04 - Arrangement or mounting of valves
  • F17C 13/06 - Closures, e.g. cap, breakable member

41.

TILTABLE DISPLAY SCREEN ASSEMBLIES, DIAGNOSTIC ANALYZERS WITH TILTABLE DISPLAY SCREEN ASSEMBLY, AND METHODS

      
Application Number US2023060945
Publication Number 2023/147253
Status In Force
Filing Date 2023-01-20
Publication Date 2023-08-03
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Chura, William

Abstract

A tiltable display screen assembly of a diagnostic analyzer. The tiltable display screen assembly includes a tiltable support interconnectable to a hand-held device including a display screen, a multi-angle adjuster having adjustment features, and a tilting screen mechanism pivotable relative to the tiltable support. The tilting screen mechanism includes a shaft, one or more moveable paddles coupled to the shaft, an adjustment member depending from the shaft configured to engage with the adjustment features of the multi-angle adjuster in order to adjust a tilt angle of the tiltable support and the display screen of the hand-held device. Diagnostic analyzers including the tiltable display screen assembly and methods for adjusting tilt angle of a display screen of a diagnostic analyzer are described, as are other aspects.

IPC Classes  ?

  • F16M 13/00 - Other supports for positioning apparatus or articles; Means for steadying hand-held apparatus or articles
  • E04G 3/00 - Scaffolds essentially supported by building constructions, e.g. adjustable in height
  • F16M 11/14 - Means for attachment of apparatus; Means allowing adjustment of the apparatus relatively to the stand allowing pivoting in more than one direction with ball-joint

42.

COMBINED TOTAL IG AND IGG IMMUNOASSAYS FOR SARS-COV-2

      
Application Number US2022081980
Publication Number 2023/122561
Status In Force
Filing Date 2022-12-19
Publication Date 2023-06-29
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Bahar, Izak
  • Wei, Tie

Abstract

Methods for determining if a patient is positive for COVID-19 infection are provided, in which immunoassays are performed to detect the presence of anti-SARS-CoV-2 total immunoglobulin antibodies (tAb) and anti-SARS-CoV-2 IgG antibodies in a patient sample. The two results are combined to provide optimal sensitivity and specificity for the COVID-19 assay. Also disclosed are kits and microfluidic devices for use in the methods.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

43.

SENSOR ASSEMBLY WITH WICKING MEMBER FOR LIQUID JUNCTION WET UP

      
Application Number US2022081408
Publication Number 2023/122446
Status In Force
Filing Date 2022-12-13
Publication Date 2023-06-29
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Wolfson, Mark
  • Pudduck, Christian

Abstract

A sensor assembly for a bodily fluid analyzer includes a reference electrode container containing a reference electrode, a membrane capable or configured to be in fluid communication with the reference electrode container; and a wicking member capable or configured to be in fluid communication with the reference electrode container. The wicking member is configured to draw a reference fluid contained in the reference electrode container towards the membrane when the membrane and the wicking member are exposed to the reference fluid.

IPC Classes  ?

  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • G01N 27/403 - Cells and electrode assemblies
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

44.

REFLEX TEST FOR IMMUNOASSAY FOR ANTI-SARS-COV-2 ANTIBODIES

      
Application Number US2022081981
Publication Number 2023/122562
Status In Force
Filing Date 2022-12-19
Publication Date 2023-06-29
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Wei, Tie

Abstract

Kits, microfluidics devices, and methods are disclosed for determining if a patient is positive for COVID-19 infection, in which immunoassays are performed to detect the presence of anti-SARS-CoV-2 antibodies in a patient sample. The kits, microfluidics devices, and methods incorporate the use of a reflex test within the reagent cartridge for the major anti-SARS-CoV-2 antibody assay, wherein the minor assay of the reflex test is employed when the result obtained in the major assay is above a baseline index. The reflex test (i.e., minor assay) utilizes at least one reagent that is different from the reagents utilized in the major assay.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/541 - Double or second antibody

45.

SYSTEM AND METHOD FOR CALIBRATING SYSTEM PARAMETERS FOR IMAGE RECONSTRUCTION

      
Application Number IB2022060454
Publication Number 2023/111708
Status In Force
Filing Date 2022-10-31
Publication Date 2023-06-22
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Joshi, Abhijeet A.
  • Azhar, Mohiudeen

Abstract

A computer implemented method, an imaging device, an image reconstruction system and a computer program product, for calibrating system parameters of the image reconstruction system are provided, and include obtaining low resolution captured images by illuminating a sample with light source(s), obtaining a high resolution representation of the captured images based on the system parameters and the captured images, generating an approximate function based on the high resolution representation and the captured images, wherein the approximate function is a function of system parameters, and generating an updated set of system parameters by optimizing the approximate function. The computer implemented method, the imaging device, the image reconstruction system, and the computer program product enhance speed of calibration of the image reconstruction system by orders of magnitude, thereby, enabling noise and artifact free microscopic imaging in a robust way for the lifetime of the microscope.

IPC Classes  ?

  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

46.

BIOTIN-TRAP BEADS AND METHODS OF PRODUCTION AND USE THEREOF

      
Application Number US2022081793
Publication Number 2023/114993
Status In Force
Filing Date 2022-12-16
Publication Date 2023-06-22
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Teng, Zhu
  • Spillane, Jesse
  • Li, Jie
  • Kennedy, Thomas
  • Krakowski, Karen
  • Bahar, Izak
  • Wei, Tie

Abstract

Biotin-trap compositions are disclosed that contain particles having an inner polymer coating layer disposed on at least a portion of an outer surface thereof and a biotin-specific binding partner conjugated to the inner polymer coating layer. The biotin-trap compositions may further include an outer polymer coating layer disposed about the biotin-specific binding partner. The biotin-trap compositions specifically bind to free biotin but do not substantially bind to biotin conjugated to other moieties, such as biotinylated assay reagents. Also disclosed are kits and microfluidics devices that include the biotin-trap compositions, as well as methods of producing and using the biotin-trap compositions.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 21/76 - Chemiluminescence; Bioluminescence
  • G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
  • G01N 33/546 - Synthetic resin as water suspendable particles
  • G01N 33/566 - Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagent
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

47.

ELECTROMAGNETIC PCB CROSSROADS TOPOLOGIES FOR AUTOMATION TRACK SYSTEMS

      
Application Number US2022079322
Publication Number 2023/081838
Status In Force
Filing Date 2022-11-04
Publication Date 2023-05-11
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Edwards, Mark

Abstract

A vessel transport system in a liquid handler system includes vessel movers that transport a sample vessel using a magnetic base. A track provides a selective magnetic field to propel the magnetic base of each vessel mover along the track using a plurality of multilayer printed circuit boards (PCB) arranged along a transport path. Each PCB has a plurality of multi-layer conductive coils within layers of the PCB and each coil has a plurality of single-layer spirals electrically coupled with one another to form a multilayer coil. A processor is configured to control selective application of currents to the plurality of multi-layer coils to create the selective magnetic field. At least a subset of the multi-layer conductive coils are stacked relative to one another below a surface of the track, such that the selective application of currents selects one of a plurality of branching paths along the track.

IPC Classes  ?

  • H01F 27/32 - Insulating of coils, windings, or parts thereof
  • H01F 5/06 - Insulation of windings
  • H01F 5/04 - Arrangements of electric connections to coils, e.g. leads
  • H01F 27/28 - Coils; Windings; Conductive connections

48.

ELECTROMAGNETIC PCB TOPOLOGIES FOR AUTOMATION TRACK SYSTEMS

      
Application Number US2022079316
Publication Number 2023/081834
Status In Force
Filing Date 2022-11-04
Publication Date 2023-05-11
Owner SIEMENS HEALTHCARE DIAGNOSTICS Inc. (USA)
Inventor
  • Edwards, Mark
  • Mahmood, Faisal
  • Günther, Sven
  • Hafenecker, Sven
  • Spain, Steven

Abstract

A transport track for selectively routing magnetic vessel movers includes a plurality of multilayer printed circuit boards (PCB) arranged adjacent to one another such that a surface of each PCB provides a track surface along which the magnetic vessel movers ride. A plurality of conductive coils are formed within one of the PCBs and include a plurality of single-layer spirals electrically coupled in a stack with one another to form a multilayer coil. A processor is configured to control selective application of currents to the plurality of multi-layer coils to create a magnetic field to propel the magnetic vessel movers along the track. The plurality of conductive coils are arranged adjacent to one another in each PCB to create at least one continuous path for the magnetic vessel movers to move along.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • H02K 1/12 - Stationary parts of the magnetic circuit
  • G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades

49.

HANDS-FREE SAMPLE INSERTION APPARATUS AND METHODS

      
Application Number US2022078188
Publication Number 2023/069885
Status In Force
Filing Date 2022-10-17
Publication Date 2023-04-27
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Galano, Kenneth

Abstract

A sample insertion apparatus enabling a sample to be inserted into a diagnostic analyzer in a hands-free manner. The sample insertion apparatus includes an insertion head having a coupler configured to couple to a sample container having an insertion member, an arm containing a sample probe positioned stationary relative to the arm, and a retraction assembly coupled to the insertion head and configured to cause the sample container to move towards the sample probe to insert the sample probe into the insertion member. Sample insertion and operating methods for hands-free insertion of a sample into a diagnostic analyzer are described, as are other aspects.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

50.

FLUIDIC TUBING ASSEMBLY FOR BLOOD ANALYZER

      
Application Number US2022078190
Publication Number 2023/069886
Status In Force
Filing Date 2022-10-17
Publication Date 2023-04-27
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Pudduck, Christian

Abstract

A fluidic tubing assembly and method for a blood analyzer comprising a base, a first tube, and a second tube. The base is connectable to the blood analyzer and has a front side, a rear side, a first side, a second side, a top side, and a bottom side. A first connector is supported by the first side. The first end of the first tube is connected to the first connector. A second connector is supported by the top side. The second end of the first tube is connected to the second connector. A third connector is supported by the top side. The first end of the second tube is connected to the third connector. A fourth connector is supported by the bottom side. The second end of the second tube is connected to the fourth connector.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/483 - Physical analysis of biological material

51.

DHEAS ASSAY, REAGENTS FOR SAME, AND METHODS OF PRODUCTION AND USE THEREOF

      
Application Number US2022076904
Publication Number 2023/064670
Status In Force
Filing Date 2022-09-23
Publication Date 2023-04-20
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Zhao, Zhijian
  • Zheng, Yi Feng
  • Rybin, Andrew
  • Freeman, James

Abstract

Immunoassay reagents are disclosed that contain a dehydroepiandrosterone sulphate-fluorescein (DHEAS-FITC) conjugate or a dehydroepiandrosterone sulphate-carboxymethoxylamino-dimethyl acridinium ester (DHEAS-CMO-DMAE) conjugate. Also disclosed are immunoassay kits and devices that contain one or more of the DHEAS conjugates. Methods of making and using the DHEAS conjugates are further disclosed.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

52.

REAGENT ANALYZER SYSTEM AND METHOD FOR REAGENT STRIP AUTHENTICATION

      
Application Number US2022078003
Publication Number 2023/064832
Status In Force
Filing Date 2022-10-13
Publication Date 2023-04-20
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Deshpande, Manish
  • Orton, Emma

Abstract

A reagent strip is described. The reagent strip includes a substrate and at least one reagent pad positioned on the substrate. The substrate has a storage unit storing control information, such as an authentication code, encoded as a part of a non-visible code. The authentication code may be used to determine if the reagent strip is authentic before testing is done or results are produced.

IPC Classes  ?

  • G06K 7/12 - Methods or arrangements for sensing record carriers by corpuscular radiation using a selected wavelength, e.g. to sense red marks and ignore blue marks
  • G01N 21/84 - Systems specially adapted for particular applications
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation

53.

MOBILE CONNECTED AUTONOMOUS REFRIGERATOR

      
Application Number US2022077310
Publication Number 2023/064682
Status In Force
Filing Date 2022-09-29
Publication Date 2023-04-20
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Heydlauf, Michael

Abstract

A method and system for replenishing refrigerated consumables by a mobile connected autonomous refrigerator includes receiving a notification triggered by a laboratory instrument that a refrigerated consumable used by the laboratory instrument is depleted; autonomously navigating to a refrigerated storage; retrieving the refrigerated consumable and placing it in the mobile refrigerated unit; autonomously moving to the laboratory instrument that triggered the notification; and alerting an operator to retrieve the refrigerated consumable from mobile refrigerated unit and load it into the laboratory instrument.

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06Q 10/08 - Logistics, e.g. warehousing, loading or distribution; Inventory or stock management
  • B25J 15/08 - Gripping heads having finger members
  • B25J 11/00 - Manipulators not otherwise provided for

54.

LATERAL FLOW DEVICES FOR DUPLEX IMMUNOASSAY FOR ANTI-SARS-COV-2 ANTIBODIES AND METHODS OF USE THEREOF

      
Application Number US2022075434
Publication Number 2023/056142
Status In Force
Filing Date 2022-08-25
Publication Date 2023-04-06
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Wei, Tie

Abstract

Lateral flow devices, kits, and methods for detecting the presence and/or concentration of anti‐SARS‐CoV‐2 antibodies in a sample are disclosed. In certain non‐limiting embodiments, the lateral flow devices, kits, and methods can distinguish between anti‐SARS‐CoV‐2 antibodies generated in response to vaccination from anti‐SARS‐CoV‐2 antibodies generated in response to infection.

IPC Classes  ?

  • G01N 33/536 - Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase

55.

COMPOSITIONS, KITS, AND METHODS FOR DUPLEX IMMUNOASSAY FOR ANTI-SARS-COV-2 ANTIBODIES

      
Application Number US2022075436
Publication Number 2023/056143
Status In Force
Filing Date 2022-08-25
Publication Date 2023-04-06
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Wei, Tie

Abstract

Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of anti-SARS-CoV-2 antibodies in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths. In certain non-limiting embodiments, the kits, microfluidics devices, and methods can distinguish between anti-SARS-CoV-2 antibodies generated in response to vaccination from anti-SARS-CoV-2 antibodies generated in response to infection.

IPC Classes  ?

  • C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)

56.

METHOD AND HEMATOLOGY ANALYZER FOR OPTICALLY ANALYZING BLOOD CELLS

      
Application Number US2022076896
Publication Number 2023/056217
Status In Force
Filing Date 2022-09-23
Publication Date 2023-04-06
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Seliger, Ramona
  • Kraus, Martin
  • Paulicka, Peter
  • Mach, Tivadar

Abstract

The disclosure relates to a method (100) of optically analyzing a blood cell from a blood sample with a device for optically analyzing a blood cell from a blood sample, the device (1) comprising a microfluidic chamber with at least one fluidic flow-through channel, a first inlet (6) port configured to introduce at least a part of the blood sample into the fluidic channel, a first outlet (7) port configured to discharge at least a part of the blood sample from the fluidic channel, a flow generating and stopping device configured to generate a flow of the sample through the channel and to stop the flow while a least a part of the sample comprising at least one blood cell is situated within the channel and wherein after stopping the flow the sample is only influenced by gravity and inertial forces such that blood cells within the sample sediment on a first area of a lower surface of the channel, wherein cells sedimented within the first area of the lower surface can be optically analyzed in the chamber, and to a hematology analyzer.

IPC Classes  ?

  • G01N 15/14 - Electro-optical investigation
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

57.

TUBE RETAINER WITH VACUUM PUMP HAVING DISK CAM

      
Application Number US2022077155
Publication Number 2023/056281
Status In Force
Filing Date 2022-09-28
Publication Date 2023-04-06
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Sorensen, George

Abstract

Embodiments provide a tube retainer system, including: an outer body; a diaphragm having a circular opening; a valve including a valve head and a valve stem attached to the valve head; a cam; a camshaft extending through the cam; a drive gear attached to the camshaft; a restraint gear attached to the camshaft; a push bar located below the diaphragm; and a pawl. The diaphragm, the cam, the drive gear, the restraint gear, the push bar, and the pawl are all provided in the outer body, when a bottom of a tube is inserted into the circular opening and a downward pressure is applied on the diaphragm, the cam is oriented to close the valve to form a partial vacuum in the outer body to secure the bottom of the tube within the circular opening.

IPC Classes  ?

58.

BIOMARKER COMPOSITIONS AND METHODS OF USE THEREOF

      
Application Number US2022076076
Publication Number 2023/039449
Status In Force
Filing Date 2022-09-07
Publication Date 2023-03-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Uzgiris, Arejas James
  • Green, Chris
  • Baumeister, Mark

Abstract

The present disclosure provides methods and kits for identifying and treating individuals at risk of or suffering from amyloid transthyretin cardiomyopathy. In general, detection or measurement of one or more biomarkers, such as TnI, PKM1, PKM2, NT-proBNP, RBP4, DCN, TIMP2, SMOC-2, NfL, or combinations thereof, assists in the identification of amyloid transthyretin cardiomyopathy. The present disclosure also provides methods for selecting patients for treatment of amyloid transthyretin cardiomyopathy, such as with transthyretin stabilizing agents.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
  • A61P 9/00 - Drugs for disorders of the cardiovascular system
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

59.

LABORATORY ANALYZERS AND METHODS OF PERFORMING STUDIES USING LABORATORY ANALYZERS

      
Application Number US2022076214
Publication Number 2023/039533
Status In Force
Filing Date 2022-09-09
Publication Date 2023-03-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Bertuccelli, Susan
  • Seltmann, Julia
  • Venart, Christine
  • Subburam, Ganesh Pandiyan

Abstract

A method of performing a study using one or more laboratory analyzers includes displaying on a display one or more evaluation studies performable on the one or more laboratory analyzers; receiving a selected evaluation study to be performed on the one or more laboratory analyzers from the one or more evaluation studies; generating, by a processor, instructions configured to operate the one or more laboratory analyzers to perform the evaluation study; and executing the instructions in the one or more laboratory analyzers. The instructions cause the one or more laboratory analyzers to perform an analysis using one or more test materials in response to the selected evaluation study. Other methods and apparatus are disclosed.

IPC Classes  ?

  • G06F 17/10 - Complex mathematical operations
  • G06F 7/02 - Comparing digital values
  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
  • G01N 30/86 - Signal analysis
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

60.

APPARATUS AND METHOD FOR REMOVING BUBBLES FROM FLUID SAMPLE WITH SLIDABLE FILTER

      
Application Number US2022074577
Publication Number 2023/019085
Status In Force
Filing Date 2022-08-05
Publication Date 2023-02-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Cox, Janine
  • Desilva, Justin

Abstract

An apparatus and method for removing bubbles from a fluid sample. The apparatus has a barrel and a filter member. The barrel has a first end, a second end, a sidewall, and an inner surface defining an internal chamber. The first side has an inlet opening and the second side has an outlet opening. The filter member is disposed within the internal chamber and defines an inlet side and an outlet side of the internal chamber. The filter member has a gas-permeable, liquid-impermeable membrane which permits the gas portion of the fluid sample to pass across the filter member from the inlet side to the outlet side. The gas-permeable, liquid-impermeable membrane provides a fluid-tight seal across the filter member. The filter member is pierceable so a probe may be passed through the filter member to withdraw the liquid portion of the fluid sample from the internal chamber.

IPC Classes  ?

61.

DYNAMOMETERS AND METHODS OF MEASURING TORQUE

      
Application Number US2022074703
Publication Number 2023/019133
Status In Force
Filing Date 2022-08-09
Publication Date 2023-02-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Dischino, Kevin
  • Ramakrishnan, Narayanan

Abstract

A dynamometer includes a torque measuring device configured to measure torque applied to the torque measuring device; a clutch having a clutch input and a clutch output, the clutch output coupled to the torque measuring device and the clutch input configured to be coupled to a motor under test; wherein friction between the clutch input and the clutch output is variable; and a dampening mechanism configured to dampen the friction between the clutch input and the clutch output. Other dynamometers and methods of measuring torque are disclosed.

IPC Classes  ?

  • G01L 3/02 - Rotary-transmission dynamometers
  • F16F 9/00 - Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
  • G01L 3/14 - Rotary-transmission dynamometers wherein the torque-transmitting element is other than a torsionally-flexible shaft
  • G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
  • G01L 5/26 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for determining the characteristic of torque in relation to revolutions per unit of time
  • G01L 3/00 - Measuring torque, work, mechanical power, or mechanical efficiency, in general

62.

A HEMATOLOGY ANALYZER COMPRISING A SINGLE HARDWARE MODULE AND INTEGRATED WORKFLOW

      
Application Number IB2022057301
Publication Number 2023/017383
Status In Force
Filing Date 2022-08-05
Publication Date 2023-02-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Mach, Tivadar
  • Paulicka, Peter
  • Seliger, Ramona
  • Stelling, Frederick

Abstract

The disclosure relates to a device and method for analyzing a blood sample, particularly including pre-analytical (qualification), analytical and post-analytical (verification) testing. More particularly the disclosure relates in certain embodiments to a device configured for collecting, imaging and lysing blood cells in a sample vessel by means of ultrasonic acoustic waves, generated in the vessel by an acoustic transducer driven at one particular excitation frequency or more particular excitation frequencies, or one range of frequency or ranges of frequencies. In some non-limiting embodiments, the ultrasonic acoustic waves are generated by a single acoustic transducer. Further on, according to certain embodiments, the device and workflow are configured for three analytical steps in single device, comprising pre-analytical (qualification), analytical and post-analytical (verification) testing.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood

63.

APPARATUS AND METHOD FOR REMOVING BUBBLES FROM FLUID SAMPLE

      
Application Number US2022074578
Publication Number 2023/019086
Status In Force
Filing Date 2022-08-05
Publication Date 2023-02-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Cox, Janine
  • Desilva, Justin

Abstract

An apparatus and method for removing bubbles from a fluid sample. The apparatus has a barrel and a filter member. The barrel has a first end, a second end, a sidewall, and an inner surface defining an internal chamber. The first side has an inlet opening and the second side has an outlet opening. The filter member is slidably disposed within the internal chamber and defines an inlet side and an outlet side of the internal chamber. The filter member has a gas-permeable, liquid-impermeable membrane which permits the gas portion of the fluid sample to pass across the filter member. The barrel has a second gas-permeable, liquid-impermeable membrane which provides a fluid-tight seal across the outlet opening.

IPC Classes  ?

  • B01D 61/38 - Liquid-membrane separation
  • A61B 5/15 - Devices for taking samples of blood
  • B01L 3/02 - Burettes; Pipettes
  • C02F 3/20 - Activated sludge processes using diffusers
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 1/38 - Diluting, dispersing or mixing samples

64.

APPARATUS AND METHOD FOR TRANSFERRING A FLUID SAMPLE FROM A FLUID SAMPLE COLLECTION APPARATUS TO A LIQUID SAMPLE ANALYZER

      
Application Number US2022074580
Publication Number 2023/019087
Status In Force
Filing Date 2022-08-05
Publication Date 2023-02-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Cox, Janine
  • Chen, Michael
  • Vaughan, Mark
  • Desilva, Justin
  • Joseph, Joshua
  • Davis, Justin

Abstract

An apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer. The apparatus includes a barrel having a first end, a second end, a sidewall extending between the first end and the second end, and an inner surface defining an internal chamber. The first end has an inlet opening and the second end having an outlet opening. The first end of the barrel has a barrel connection portion engageable with a portion of the fluid sample collection apparatus and the second end of the barrel has a tubular portion configured to engage with the liquid sample analyzer so a combination of the fluid sample collection apparatus and the barrel is attachable to the liquid sample analyzer with no additional support.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
  • B01D 63/08 - Flat membrane modules
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers

65.

APPARATUS AND METHOD FOR TRANSFERRING A FLUID SAMPLE FROM A FLUID SAMPLE COLLECTION APPARATUS TO A LIQUID SAMPLE ANALYZER

      
Application Number US2022074582
Publication Number 2023/019088
Status In Force
Filing Date 2022-08-05
Publication Date 2023-02-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Cox, Janine
  • Chen, Michael
  • Davis, Justin
  • Desilva, Justin
  • Vaughan, Mark
  • Joseph, Joshua

Abstract

An apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer. The apparatus includes a barrel having a first end, a second end, a sidewall extending between the first end and the second end, an inner surface defining an internal chamber, and an external surface defining at least a portion of a chromatographic assay chamber in fluid communication with the internal chamber. The first end has an inlet opening with a clot catcher extending across the inlet opening upstream of the passage and the second end has an outlet opening. A chromatographic assay assembly is housed in the chromatographic assay chamber for detecting presence of free hemoglobin in the fluid sample.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • B01D 63/08 - Flat membrane modules
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers

66.

REAL-TIME SAMPLE ASPIRATION FAULT DETECTION AND CONTROL

      
Application Number US2022073655
Publication Number 2023/288230
Status In Force
Filing Date 2022-07-12
Publication Date 2023-01-19
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Ramakrishnan, Narayanan

Abstract

Methods of early real-time detection or prediction of aspiration faults in an automated diagnostic analysis system include an artificial intelligence algorithm configured to use either cluster analysis or probabilistic graphical modeling based on an aspiration pressure measurement signal waveform. Aspiration faults may include short-volume aspiration and unwanted gel pick-up. These methods may allow for timely termination of an aspiration process so as to avoid or minimize possible detrimental downstream consequences such as faulty sample test results and/or instrument downtime for servicing and cleanup. Apparatus for early real-time detection or prediction of aspiration faults are provided as are other aspects.

IPC Classes  ?

  • G05B 23/02 - Electric testing or monitoring
  • G01N 21/76 - Chemiluminescence; Bioluminescence
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

67.

REAL-TIME SHORT-SAMPLE ASPIRATION FAULT DETECTION

      
Application Number US2022073657
Publication Number 2023/288232
Status In Force
Filing Date 2022-07-12
Publication Date 2023-01-19
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Ramakrishnan, Narayanan

Abstract

Methods of real-time detection of short-sample aspiration faults in an automated diagnostic analysis system include spectral analysis of a pressure slope waveform based on aspiration pressure measurement signals. The spectral analysis may include using a moving average filter or a wavelet transform, such as, e.g., a continuous wavelet transform (CWT) or a discrete wavelet transform (DWT), to identify distinct transient behavior in the pressure slope waveform. These methods accurately identify short-sample aspiration faults such that an automated diagnostic analysis system can timely terminate an analysis of a detected short sample to avoid a possibly erroneous sample test result. Apparatus for real-time detection of short-sample aspiration faults is also provided, as are other aspects.

IPC Classes  ?

  • G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

68.

DETECTION OF ABNORMAL HEAT EXCHANGER OPERATING CONDITION

      
Application Number US2022073734
Publication Number 2023/288272
Status In Force
Filing Date 2022-07-14
Publication Date 2023-01-19
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Ramakrishnan, Narayanan

Abstract

A method for detecting an abnormal operating condition of a heat exchanger is provided. The method includes determining the actual current through a heat exchanger, using the actual current to indicate an abnormal operating condition, and declaring a fault state. A step of comparing the baseline current to the actual current includes normalizing the actual current, calculating a difference between the normalized actual current and the baseline current, and determining that difference is less than zero.

IPC Classes  ?

  • F24F 11/36 - Responding to malfunctions or emergencies to leakage of heat-exchange fluid
  • F28F 27/00 - Control arrangements or safety devices specially adapted for heat-exchange or heat-transfer apparatus
  • F24F 11/38 - Failure diagnosis

69.

METHOD AND SYSTEM FOR PROCESSING MEDICAL IMAGE

      
Application Number IB2021056032
Publication Number 2023/281294
Status In Force
Filing Date 2021-07-06
Publication Date 2023-01-12
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Azhar, Mohiudeen
  • Joshi, Abhijeet A.
  • Savarni K R, Vaishnav Ram

Abstract

A method (200), and a system (100) for processing medical images is provided. In one aspect, the method (200) includes receiving the medical image, wherein the medical image comprises a plurality of objects, wherein the medical image is a low-resolution image. Further, the method (200) includes segmenting at least one object from the plurality of objects from the medical image. Additionally, the method (200) includes identifying at least one region of interest in the medical image, wherein the region of interest comprises the at least one object, wherein the at least one object is clinically relevant. Furthermore, the method (200) includes generating a high-resolution image of the region of interest. The method also includes displaying the high-resolution image of the region of interest on a display unit.

IPC Classes  ?

  • G06T 3/40 - Scaling of a whole image or part thereof
  • G02B 21/00 - Microscopes
  • G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
  • G06T 7/11 - Region-based segmentation
  • G06T 7/136 - Segmentation; Edge detection involving thresholding
  • G06T 7/155 - Segmentation; Edge detection involving morphological operators

70.

SITE-SPECIFIC ADAPTATION OF AUTOMATED DIAGNOSTIC ANALYSIS SYSTEMS

      
Application Number US2022073473
Publication Number 2023/283583
Status In Force
Filing Date 2022-07-06
Publication Date 2023-01-12
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Narasimhamurthy, Venkatesh
  • Singh, Vivek
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur
  • Nalam Venkat, Rayal Raj Prasad

Abstract

Methods of characterizing a sample container or a biological sample in an automated diagnostic analysis system using an artificial intelligence (AI) algorithm include retraining of the AI algorithm in response to characterization confidence levels determined to be unsatisfactory. The AI algorithm is retrained with data (including image data and/or non-image data) having features prevalent at the site where the automated diagnostic analysis system is operated, which were not sufficiently or at all included in training data used to initially train the AI algorithm. Systems for characterizing a sample container or a biological sample using an AI algorithm are also provided, as are other aspects.

IPC Classes  ?

  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G06N 3/08 - Learning methods
  • G06T 7/00 - Image analysis
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

71.

METHODS AND APPARATUS PROVIDING TRAINING UPDATES IN AUTOMATED DIAGNOSTIC SYSTEMS

      
Application Number US2022073474
Publication Number 2023/283584
Status In Force
Filing Date 2022-07-06
Publication Date 2023-01-12
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Narasimhamurthy, Venkatesh
  • Singh, Vivek
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur
  • Nalam Venkat, Rayal Raj Prasad

Abstract

A method of characterizing a specimen container or a specimen in an automated diagnostic system includes capturing an image of a specimen container containing a specimen using an imaging device. The method further includes characterizing the image using a first AI model and determining whether a characterization confidence of the image is below a pre-selected threshold. The first AI model is retrained with the image having the characterization confidence below the pre-selected threshold to a second AI model, wherein the retraining includes data selected from one or more of a group of: non-image data, and text data. Quality check modules and systems configured to perform the method are also described, as are other aspects.

IPC Classes  ?

  • G06T 7/00 - Image analysis
  • G06K 9/62 - Methods or arrangements for recognition using electronic means
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

72.

APPARATUS AND METHODS OF MONITORING ITEMS IN DIAGNOSTIC LABORATORY SYSTEMS

      
Application Number US2022072944
Publication Number 2022/266628
Status In Force
Filing Date 2022-06-15
Publication Date 2022-12-22
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chang, Yao-Jen
  • Nalam Venkat, Rayal Raj Prasad
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A method of monitoring a specimen container or specimen in a diagnostic laboratory system includes moving the specimen container on a track within the diagnostic laboratory system; moving a sensor module on the track; and monitoring at least one characteristic of the specimen container or a specimen located in the specimen container using the sensor module. Other methods, sensor modules, and diagnostic laboratory systems are disclosed.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 29/26 - Arrangements for orientation or scanning
  • G01N 29/275 - Arrangements for orientation or scanning by moving both the sensor and the material

73.

ANALYZER HAVING AUTOMATIC TEST TYPE SENSING

      
Application Number US2022071811
Publication Number 2022/226504
Status In Force
Filing Date 2022-04-20
Publication Date 2022-10-27
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Deshpande, Manish
  • Warner, Ethan
  • Orton, Emma

Abstract

An automated analyzer is described. The analyzer includes a housing, a consumable insert, a consumable support device, a reader and a control system. The housing has a sample port. The consumable insert has a consumable insert type and an identification component and receives a consumable. The consumable support device is disposed within the sample port, supports the consumable insert, and is moveable to a testing position within the internal cavity. The consumable support device has an identifier component configured to identify the consumable insert type based in part on the identification component and configured to output a first data signal indicative of the consumable insert type. The reader outputs a second data signal indicative of a reading from the consumable. The control system receives the first and second data signals, and interprets the second data signal based on the first data signal.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation
  • H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
  • A61B 90/90 - Identification means for patients or instruments, e.g. tags
  • A61B 90/98 - Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders

74.

COMPOSITIONS, KITS, AND METHODS FOR ANTI-MICROBIAL SEROLOGY ASSAYS USING ANTI-HUMAN IMMUNOGLOBULIN ANTIBODY

      
Application Number US2021070435
Publication Number 2022/225575
Status In Force
Filing Date 2021-04-21
Publication Date 2022-10-27
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Wei, Tie

Abstract

Reagents, kits, and microfluidics devices are disclosed for detecting the presence and/or concentration of antibodies directed to microorganisms in human biological samples. Also disclosed are methods of production and use of the reagents, kits, and microfluidics devices. Anti-human immunoglobulin antibodies are utilized as a reagent in a bridging immunoassay for detection of the microorganisms.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • C09K 11/07 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

75.

DIAGNOSTIC INSTRUMENTS HAVING MULTIPLE ILLUMINATION SOURCES AND METHODS THEREOF

      
Application Number US2022071367
Publication Number 2022/221811
Status In Force
Filing Date 2022-03-25
Publication Date 2022-10-20
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Nalam Venkat, Rayal Raj Prasad
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A method of operating a diagnostic instrument includes illuminating an imaging location of the diagnostic instrument with first light having a first spectrum for a first period and capturing a first image of the imaging location illuminated by the first light. The method further includes illuminating the imaging location of the diagnostic instrument with second light having a second spectrum for a second period, the second spectrum being more destructive to a chemical configured to be received in the diagnostic instrument than the first spectrum; and capturing a second image of the imaging location illuminated by the second light. Other methods and diagnostic instruments are disclosed.

IPC Classes  ?

  • G01J 3/50 - Measurement of colour; Colour measuring devices, e.g. colorimeters using electric radiation detectors
  • G01N 21/21 - Polarisation-affecting properties
  • G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule

76.

DIAGNOSTIC INSTRUMENTS HAVING SORTING CAPABILITY AND SORTING METHODS THEREOF

      
Application Number US2022071366
Publication Number 2022/213047
Status In Force
Filing Date 2022-03-25
Publication Date 2022-10-06
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Ahmed, Muhammad
  • Arbabi, Hadi
  • Manning, Shane
  • Jain, Navneet

Abstract

Diagnostic instruments and methods of operating diagnostic instruments are provided. Methods of operating a diagnostic instrument includes providing the diagnostic instrument having one or more modules, wherein the one or more modules are configured to analyze specimens; providing a specimen sorter coupled to the diagnostic instrument; and sorting specimens into at least first group and a second group, wherein specimens in the first group are to be analyzed by at least one of the one or more modules, and specimens in the second group are not to be analyzed by any of the one or more modules. Other sorting methods and diagnostic instruments are provided.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
  • A61J 1/06 - Ampoules or cartridges

77.

READY TO USE ANALYZER CONTROL PRODUCT FOR CUA URINALYSIS INSTRUMENTS

      
Application Number US2022071375
Publication Number 2022/213049
Status In Force
Filing Date 2022-03-28
Publication Date 2022-10-06
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Schulman, Lloyd

Abstract

An analyzer control product provided with a sealed rack tube containing a preconfigured volume of analyzer control fluid is described. In particular, the rack tube is provided with a base portion; a top portion; and a sidewall extending from the base portion to the top portion, the sidewall having an inner peripheral surface and an outer peripheral surface, at least one of the inner peripheral surface and the outer peripheral surface in contact with the base portion to form a control fluid void. The analyzer control fluid is within the control fluid void. The analyzer control fluid has a preconfigured volume. A sealing member is attached to the top portion to seal the control void.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

78.

METHOD, DEVICE AND SYSTEM FOR ENHANCING IMAGE QUALITY

      
Application Number US2021070249
Publication Number 2022/191900
Status In Force
Filing Date 2021-03-08
Publication Date 2022-09-15
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Joshi, Abhijeet A.
  • Azhar, Mohiudeen

Abstract

A method, device and system for enhancing image quality of an image is provided. In one aspect, the method includes illuminating a sample with a light source associated with an imaging device. Further, the method includes simulating a transmission wave at a sensor plane of the imaging device for a light wave from illuminating the sample. Additionally, the method includes determining a phase and amplitude information associated with the light wave based on the transmission wave. The method also includes determining at least one microscope transfer function associated with the imaging device based on the phase and amplitude information. Furthermore, the method includes generating a modified mi-croscope transfer function using a Zernike function based on the at least one microscope transfer function in an iterative procedure and enhancing the image quality associated with the im-age using the modified microscope transfer function.

IPC Classes  ?

  • G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

79.

DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF OPERATING

      
Application Number US2022070700
Publication Number 2022/178518
Status In Force
Filing Date 2022-02-17
Publication Date 2022-08-25
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chang, Yao-Jen
  • Nalam Venkat, Rayal Raj Prasad
  • Pollack, Benjamin S.
  • Singh, Vivek
  • Narasimhamurthy, Venkatesh
  • Kapoor, Ankur

Abstract

Methods of operating a diagnostic laboratory system include providing a module configured to perform a function on an item in the diagnostic laboratory system; providing a plurality of sensors, each of the plurality of sensors configured to monitor the function or the item and generate sensor data in response to the monitoring; checking an operational status of a first sensor of the plurality of sensors; receiving sensor data from at least one of the plurality of sensors; and scaling sensor data from the first sensor in response to the operational status and the sensor data to generate revised sensor data. Systems including a middleware server configured to carry out the methods are provided as are other aspects.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 21/13 - Moving of cuvettes or solid samples to or from the investigating station
  • G01F 22/00 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
  • G01F 22/02 - Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure

80.

METHODS AND APPARATUS ADAPTED TO IDENTIFY 3D CENTER LOCATION OF A SPECIMEN CONTAINER USING A SINGLE IMAGE CAPTURE DEVICE

      
Application Number US2022070605
Publication Number 2022/174239
Status In Force
Filing Date 2022-02-10
Publication Date 2022-08-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Nalam Venkat, Rayal Raj Prasad
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A method of determining a 3D center location of a specimen container on a track. The method includes providing a calibration object on the track; providing an initially calibrated image capture device adjacent to the track; moving the calibration object to at least two different longitudinal positions along the track; capturing a first image with the calibration object located at the first longitudinal position; capturing a second image with the calibration object located at the second longitudinal position; and determining a three-dimensional path trajectory of a center location along the track based at least upon the first image and the second image. The method can be used to determine a 3D center location of a specimen container imaged anywhere within a viewing area. Characterization apparatus and specimen testing apparatus adapted to carry out the methods are described, as are other aspects.

IPC Classes  ?

  • G06T 7/20 - Analysis of motion
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G06T 7/00 - Image analysis

81.

SAMPLE LYSIS REAGENT COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF

      
Application Number US2022012514
Publication Number 2022/173553
Status In Force
Filing Date 2022-01-14
Publication Date 2022-08-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Patibandla, Sai
  • Singh, Krishna
  • Arrode-Bruses, Geraldine

Abstract

Methods of utilizing sample lysis reagent compositions in the handling of samples containing viruses, such as (but not limited to) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are disclosed. Kits containing the sample lysis reagent compositions are also disclosed.

IPC Classes  ?

  • C12N 7/06 - Inactivation or attenuation; Producing viral sub-units by chemical treatment
  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

82.

APPARATUS AND METHODS FOR ALIGNING A ROBOTIC ARM WITH A SAMPLE TUBE CARRIER

      
Application Number US2022070606
Publication Number 2022/174240
Status In Force
Filing Date 2022-02-10
Publication Date 2022-08-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Chang, Yao-Jen
  • Nalam Venkat, Rayal Raj Prasad
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

Apparatus for robotic arm alignment in an automated sample analysis system includes a robotic arm, a sample tube carrier, a plurality of optical components (including, e.g., one or more cameras), and a controller. The controller is operative to process images received from the optical components to determine a first set of coordinates of a first marker relative to the sample tube carrier and determine a second set of coordinates of a second marker relative to the robotic arm. The controller is further operative to adjust the position of the robotic arm and/or the sample tube carrier in response to an excessive offset between the first and second sets of coordinates. In some embodiments, a positioning tool includes the first and second markers thereon. Methods of robotic arm alignment with a sample tube carrier in an automated sample analysis system are also provided, as are other aspects.

IPC Classes  ?

  • B25J 9/16 - Programme controls
  • B25J 19/02 - Sensing devices
  • G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

83.

APPARATUS AND METHODS OF ALIGNING COMPONENTS OF DIAGNOSTIC LABORATORY SYSTEMS

      
Application Number US2022070609
Publication Number 2022/174241
Status In Force
Filing Date 2022-02-10
Publication Date 2022-08-18
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Nalam Venkat, Rayal Raj Prasad
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

A method of aligning a component to a structure in a diagnostic laboratory system. The method includes aligning a position sensor to the structure; sensing a position of the component using the position sensor; and calculating the position of the component relative to the structure based at least in part on the sensing. Other methods, apparatus, and systems are disclosed.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

84.

APPARATUS AND METHODS OF DETECTING DEFECTS IN MACHINE VISION SYSTEMS

      
Application Number US2022014992
Publication Number 2022/169910
Status In Force
Filing Date 2022-02-02
Publication Date 2022-08-11
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Nalam Venkat, Rayal Raj Prasad
  • Chang, Yao-Jen
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

Methods of identifying a defect in a machine vision system. Embodiments of the method include providing a first imaging device having a first field of view; moving a reflective tool through the first field of view; capturing a plurality of images of the reflective tool at different locations in the first field of view using the first imaging device; and analyzing at least one of the plurality of images to identify one or more defects in the machine vision system. Systems and apparatus configured to carry out the methods are provided, as are other aspects.

IPC Classes  ?

  • G01N 21/88 - Investigating the presence of flaws, defects or contamination
  • G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
  • G01N 21/95 - Investigating the presence of flaws, defects or contamination characterised by the material or shape of the object to be examined
  • G06K 9/46 - Extraction of features or characteristics of the image
  • G06K 9/20 - Image acquisition

85.

HIGH-SENSITIVITY CHEMILUMINESCENCE DETECTION SYSTEMS AND METHODS

      
Application Number US2022070461
Publication Number 2022/170313
Status In Force
Filing Date 2022-02-01
Publication Date 2022-08-11
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Mach, Tivadar

Abstract

A luminescence detection system for use in immunoassay testing. Luminescence detection system comprises a sample holder configured to hold a test sample including labeled components, wherein the labeled components in the test sample undergo a chemiluminescent reaction and emit luminescent emissions over a first wavelength range, a photodetector having a light entrance window configured to receive light emissions, the photodetector having a maximum detection efficiency wavelength range, and a conversion member provided adjacent the light entrance window that operates to cause conversion of the luminescent emissions over the first wavelength range to incident emissions of a second wavelength range wherein an incident peak of the incident emissions falls within the maximum detection efficiency wavelength range where the quantum efficiency of the photodetector is 10% or more. Methods of luminescence detection are provided, as are other aspects.

IPC Classes  ?

  • G01N 21/76 - Chemiluminescence; Bioluminescence
  • G01N 21/64 - Fluorescence; Phosphorescence
  • G01J 1/58 - Photometry, e.g. photographic exposure meter using luminescence generated by light
  • C09K 11/00 - Luminescent, e.g. electroluminescent, chemiluminescent, materials

86.

APPARATUS AND METHODS OF PREDICTING FAULTS IN DIAGNOSTIC LABORATORY SYSTEMS

      
Application Number US2022070546
Publication Number 2022/170357
Status In Force
Filing Date 2022-02-07
Publication Date 2022-08-11
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Singh, Vivek
  • Nalam Venkat, Rayal Raj Prasad
  • Chang, Yao-Jen
  • Narasimhamurthy, Venkatesh
  • Pollack, Benjamin S.
  • Kapoor, Ankur

Abstract

Methods of predicting a fault in a diagnostic laboratory system include providing one or more sensors; generating data using the one or more sensors; inputting the data into an artificial intelligence algorithm, the artificial intelligence algorithm configured to predict at least one fault in the diagnostic laboratory system in response to the data; and predicting at least one fault in the diagnostic laboratory system using the artificial intelligence algorithm. Other methods, systems, and apparatus are also disclosed.

IPC Classes  ?

  • G05B 23/02 - Electric testing or monitoring
  • G06F 11/00 - Error detection; Error correction; Monitoring
  • G01B 7/00 - Measuring arrangements characterised by the use of electric or magnetic techniques
  • G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
  • H02H 3/04 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection - Details with warning or supervision in addition to disconnection, e.g. for indicating that protective apparatus has functioned

87.

LABELS COMPRISING DIBROMOPYRIDAZINEDIONES FOR IMMUNOASSAYS AND METHODS OF PRODUCTION AND USE THEREOF

      
Application Number US2021072319
Publication Number 2022/126055
Status In Force
Filing Date 2021-11-10
Publication Date 2022-06-16
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Yang, Yali
  • Wen, David
  • Draghici, Bogdan
  • Zheng, Yi Feng
  • Bartz, Raphael
  • Jiang, Qingping
  • Janzen, Roland
  • Whalen, Joshua
  • Ngo, Ling
  • Bedzyk, William

Abstract

Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and/or conjugates are also disclosed, along with microfluidics devices containing same.

IPC Classes  ?

  • A61K 31/50 - Pyridazines; Hydrogenated pyridazines
  • A61K 31/501 - Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
  • C09B 62/12 - Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring to a pyridazine ring
  • A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
  • A61K 47/51 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
  • A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
  • A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

88.

COMPUTATIONALLY-EFFICIENT LOAD PLANNING SYSTEMS AND METHODS OF DIAGNOSTIC LABORATORIES

      
Application Number US2021072085
Publication Number 2022/104311
Status In Force
Filing Date 2021-10-28
Publication Date 2022-05-19
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Tuysuzoglu, Ahmet
  • Zhang, Yue
  • Heydlauf, Michael
  • Zheng, Luxi

Abstract

Systems and methods include an optimization-based load planning module including a data-reduction scheme for analyzers of bio-fluid samples. The optimization-based load planning module is executable on a computer server and is configured to optimize assay type assignments across a large number of analyzers based on one or more objectives, such as: load balancing, efficient reagent usage, reduced turn-around-time, reduced quality assurance costs, and/or improved system robustness. The optimization-based load planning module uses a data-reduction scheme to generate a load plan comprising computer-executable instructions configured to cause a system controller of a diagnostic laboratory system to assign each of the requested test types to be performed over the planning period to one or more selected analyzers in accordance with the one or more preferences or priorities. Other aspects are also described.

IPC Classes  ?

89.

VALVE FOR MICROFLUIDIC DEVICE

      
Application Number US2021072369
Publication Number 2022/104365
Status In Force
Filing Date 2021-11-12
Publication Date 2022-05-19
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Kauffmann, Aaron

Abstract

A microfluidic device has a first substrate, a resilient diaphragm, an actuator, and a second substrate. The first substrate has an opening extending therethrough. The resilient diaphragm is secured to a second side and surrounds the opening. The actuator is secured to a first side and surrounds the opening. The first substrate, the resilient diaphragm, and the actuator cooperate to form a gas-tight chamber. The second substrate has a channel formed therein having a first end and a second end. The second substrate is secured to the first substrate. A volume of gas disposed in the gas-tight chamber pressurizes the gas-tight chamber and expands the resilient diaphragm such that the resilient diaphragm is disposed in the channel between the first end and the second end. The resilient diaphragm retracts from the channel to open the channel from the first end and the second when the gas-tight chamber is depressurized.

IPC Classes  ?

  • F16K 99/00 - Subject matter not provided for in other groups of this subclass
  • F15C 5/00 - Manufacture of fluid-circuit elements; Manufacture of assemblages of such elements
  • F04B 43/02 - Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms

90.

DIAGNOSTIC LABORATORY SYSTEMS, ANALYZER INSTRUMENTS, AND CONTROL METHODS

      
Application Number US2021071743
Publication Number 2022/099235
Status In Force
Filing Date 2021-10-06
Publication Date 2022-05-12
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Tarnawski, Dariusz
  • Killeen, Gerard
  • Kozak, Elizabeth

Abstract

Methods of controlling diagnostic laboratory systems include providing one or more modules, each of the one or more modules configured to process a specimen container and/or analyze a specimen; providing middleware configured to communicate with the one or more modules, wherein the middleware is configured to generate instructions to change an operational state of at least one of the one or more modules to enabled or disabled; generating, by the middleware, one or more instructions to change the operational state of at least one of the one or more modules; and changing the operational state of at least one of the one or more modules in response to one or more instructions generated by the middleware. Systems including a middleware server configured to carry out the methods are provided as are other aspects.

IPC Classes  ?

  • G01N 33/483 - Physical analysis of biological material
  • A61B 10/02 - Instruments for taking cell samples or for biopsy
  • G01N 1/28 - Preparing specimens for investigation
  • G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control (DNC), flexible manufacturing systems (FMS), integrated manufacturing systems (IMS), computer integrated manufacturing (CIM)

91.

SAMPLE STATUS VISUALIZATION METHODS AND DIAGNOSTIC LABORATORY SYSTEMS INCLUDING SAME

      
Application Number US2021071459
Publication Number 2022/094504
Status In Force
Filing Date 2021-09-15
Publication Date 2022-05-05
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Morales, Elizabeth C.

Abstract

Methods of visualizing sample status within a diagnostic laboratory system are provided. The methods include displaying on a display screen, a visual image representing a layout of a plurality of laboratory analyzers included within the diagnostic laboratory system, and further to display on the visual image, for a particular selected sample scheduled for testing, status indicators located proximate to the visual images of the analyzers on which the tests are scheduled. The status indicators denote: the testing is completed on one or more analyzers (processed), the testing is currently being conducted on one or more analyzers (current), or the testing has not yet been received on the one or more analyzers (to do). Systems including such sample status indicators are provided as are other aspects.

IPC Classes  ?

  • G01N 1/00 - Sampling; Preparing specimens for investigation

92.

SAMPLE COLLECTION APPARATUS AND METHODS FOR IMMUNOASSAY TESTING

      
Application Number US2021055602
Publication Number 2022/086955
Status In Force
Filing Date 2021-10-19
Publication Date 2022-04-28
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Ledden, David
  • Mayfield, Jeffrey
  • Huff, Hollie

Abstract

A method of increasing a concentration of an antigen of a respiratory virus is provided. The method includes preparing a sample containing a first concentration of the antigen; contacting the sample containing the first concentration of the antigen to a first material having a negatively-charged surface, thereby capturing an amount of the antigen with the first material; contacting a second material to the first material to transfer the antigen from the first material to the second material, the second material having an ionic strength sufficient to release the captured antigen from the first material into the second material; and obtaining a resulting solution containing the antigen in a second concentration. The second concentration of the antigen in the resulting solution is higher than the first concentration of the antigen in the sample. Numerous other aspects in accordance with this and other embodiments are provided.

IPC Classes  ?

  • C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
  • C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
  • G01N 33/557 - Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction

93.

MULTI-POINT FILTERING LIQUID LEVEL DETECTION METHODS AND APPARATUS

      
Application Number US2021053851
Publication Number 2022/076616
Status In Force
Filing Date 2021-10-06
Publication Date 2022-04-14
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Dunfee, William, D.
  • Sprenkle, Mark, H.
  • Ingersoll, Colin

Abstract

A method of detecting a level of a liquid in a well of a container. The method includes looking up an expected liquid level of the liquid in the well of a container; measuring and recording a measured liquid level of the liquid in the well; changing a level of the liquid in the well based upon an expected amount of the liquid to be added or removed; and calculating a next expected liquid level at least in part based on multi-point filtering. Apparatus for carrying out the method are provided, as are other aspects.

IPC Classes  ?

  • G01F 23/00 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

94.

SYSTEM, METHOD AND POINT OF CARE DEVICE FOR IMAGE ANALYSIS OF DIAGNOSTIC ASSAYS

      
Application Number US2021051916
Publication Number 2022/072230
Status In Force
Filing Date 2021-09-24
Publication Date 2022-04-07
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Issani, Siraj
  • Pradhan, Simit
  • Galgalkar, Sudipa
  • Deshpande, Manish

Abstract

An image analysis system, a method and a point of care device are provided for determining, from an image of a cassette containing a sample, a concentration of one or more target analytes in the sample. The method includes identifying a region of interest (ROI) from the image corresponding to a result viewing area of the cassette, generating a unidimensional (1D) profile of the ROI, and probabilistically determining from the 1D profile, the concentration of the target analyte(s) in the sample based on a statistical model having one or more parameters of the 1D profile varying with respect to time and/or the concentration of the target analyte(s) in the sample.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

95.

REAGENT ANALYZER SYSTEM AND METHOD FOR REAGENT STRIP AUTHENTICATION

      
Application Number US2021051485
Publication Number 2022/066719
Status In Force
Filing Date 2021-09-22
Publication Date 2022-03-31
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Kauffmann, Aaron
  • Deshpande, Manish

Abstract

A reagent strip is described. The reagent strip includes a substrate and at least one reagent pad positioned on the substrate. The substrate has a storage unit storing an authentication code. The authentication code has a lot value and a secondary value related to the lot value by a predetermined function assigned to the lot value.

IPC Classes  ?

  • G06K 7/00 - Methods or arrangements for sensing record carriers

96.

SENSOR ARRAY

      
Application Number US2021048179
Publication Number 2022/055737
Status In Force
Filing Date 2021-08-30
Publication Date 2022-03-17
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Samproni, Jennifer

Abstract

A sensor array is disclosed. The sensor array includes a fluid inlet, a fluid outlet, a flow path extending between the fluid inlet and the fluid outlet; and at least one optimization sensor positioned outside of the flow path of the sensor array and configured to provide at least one performance parameter of the sensor array. The at least one performance parameter having performance data of the sensor array.

IPC Classes  ?

  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

97.

DIAGNOSTIC ANALYZER HAVING A DUAL-PURPOSE IMAGER

      
Application Number US2021048173
Publication Number 2022/051210
Status In Force
Filing Date 2021-08-30
Publication Date 2022-03-10
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor Deshpande, Manish

Abstract

A reagent analyzer comprising an imaging system having a first field of view of a reagent test device and a second field of view of a fluid sample information indicator, and configured to capture a first image depicting the reagent test device and a second image depicting the information indicator; a mirror moveable between a first position outside the first field of view and a second position inside the first field of view and located between the imaging system and the reagent test device, the mirror in the second position reflecting light to produce the second field of view; and a processor executing instructions to: receive the first and second images; analyze the first image to determine calibration information from the information indicator; and analyze the second image to determine constituent presence/absence in the fluid sample applied to the reagent test device, using, in part, the determined calibration information.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 15/14 - Electro-optical investigation
  • G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
  • G01N 21/59 - Transmissivity
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G06K 9/62 - Methods or arrangements for recognition using electronic means
  • G06T 7/10 - Segmentation; Edge detection

98.

ESTIMATING PATIENT RISK OF CYTOKINE STORM USING BIOMARKERS

      
Application Number EP2021071783
Publication Number 2022/033938
Status In Force
Filing Date 2021-08-04
Publication Date 2022-02-17
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Comaniciu, Dorin
  • Kamen, Ali
  • Kapoor, Ankur
  • Sharma, Puneet
  • Siebert, Matthias
  • Singh, Vivek

Abstract

Systems and methods for determining an assessment of a patient for a medical condition are provided. Input medical data of a patient is received. A vector representing a state of the patient is generated based on the input medical data. An assessment of the patient for a medical condition is determined using a machine learning based network based on the vector. The assessment of the patient is output.

IPC Classes  ?

  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

99.

ESTIMATING PATIENT RISK OF CYTOKINE STORM USING KNOWLEDGE GRAPHS

      
Application Number EP2021071781
Publication Number 2022/033937
Status In Force
Filing Date 2021-08-04
Publication Date 2022-02-17
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Comaniciu, Dorin
  • Kamen, Ali
  • Kapoor, Ankur
  • Sharma, Puneet
  • Siebert, Matthias
  • Singh, Vivek

Abstract

Systems and methods for determining an assessment of a patient for a medical condition are provided. Input medical data of a patient is received. A knowledge graph is computed based on the input medical data. A vector representing a state of the patient is generated based on the knowledge graph. An assessment of the patient for a medical condition is determined using a machine learning based network based on the vector. The assessment of the patient is output.

IPC Classes  ?

  • G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

100.

CIRCUIT BOARD WITH ONBOARD LIGHT SOURCES

      
Application Number US2021045374
Publication Number 2022/035846
Status In Force
Filing Date 2021-08-10
Publication Date 2022-02-17
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC. (USA)
Inventor
  • Deshpande, Manish
  • Howard Iii, Willis

Abstract

A reagent analyzer having a circuit board, an imaging system and a processor is disclosed. The circuit board has a substrate, and a plurality of conductive leads. The substrate has a first and a second major surface. The first major surface is opposite the second major surface. The substrate has an opening extending between the first major surface and the second major surface. The reagent analyzer also includes an imaging system having a field of view extending through the opening formed in the substrate and configured to capture an image of a wet reagent test device positioned at a read position in the field of view, the image having a plurality of pixels. The processor is configured to receive the image, and to analyze pixels of the image to determine a presence or an absence of a target constituent being in a sample applied to the wet reagent pad.

IPC Classes  ?

  • F21L 4/00 - Electric lighting devices with self-contained electric batteries or cells
  • F21V 29/507 - Cooling arrangements characterised by the adaptation for cooling of specific components of means for protecting lighting devices from damage, e.g. housings
  • F21V 29/70 - Cooling arrangements characterised by passive heat-dissipating elements, e.g. heat-sinks
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