Disclosed are DNA polymerases having increased 5′-3′ strand displacement activity and substantially reduced 5′-3′ exonuclease and endonuclease activity relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, oligonucleotide primers and oligonucleotide probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).
C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
3.
MEDICAL TREATMENT METRIC MODELLING BASED ON MACHINE LEARNING
In one example, an apparatus comprises a treatment metric model database that stores a plurality of treatment metric models, each of the plurality of treatment metric models being generated for a first cluster of cluster features vectors, each cluster feature vector representing a distribution for each of a plurality of data categories of patients data represented by patient feature vectors clustered in a second cluster. The apparatus is further configured to: receive patient characteristics features data of a patient; identify a first treatment metric model based on the patient characteristics features data of the patient; input the first patient characteristic features data and data representing a range of administrations of the treatment to the first treatment metric model to compute a range of the treatment metric; and select an administration of the treatment from the range of administrations of the treatment having optimal treatment metric.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G06F 17/18 - Complex mathematical operations for evaluating statistical data
G06F 18/2113 - Selection of the most significant subset of features by ranking or filtering the set of features, e.g. using a measure of variance or of feature cross-correlation
G06F 18/23213 - Non-hierarchical techniques using statistics or function optimisation, e.g. modelling of probability density functions with fixed number of clusters, e.g. K-means clustering
G06F 18/2411 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on the proximity to a decision surface, e.g. support vector machines
G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
In one embodiment, a method includes indexing a whole slide image dataset to generate one or more dataset embeddings corresponding to one or more respective regions of one or more whole slide images. Each dataset embedding includes a feature vector mapping the respective region to a feature embedding space. The method includes accessing a query image and generating an embedding for the query image that includes a feature vector mapping the query image to the feature embedding space. The method includes identifying result tiles by comparing the embedding for the query image to one or more of the dataset embeddings. The comparison is based on one or more distances between the embedding for the query image and the one or more of the dataset embeddings in the feature embedding space. The method includes generating a user interface including a display of the result tiles.
G06F 16/583 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually using metadata automatically derived from the content
G06F 16/51 - Indexing; Data structures therefor; Storage structures
G06F 16/532 - Query formulation, e.g. graphical querying
G06F 16/535 - Filtering based on additional data, e.g. user or group profiles
A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.
The present invention relates to methods for the specific lysis of eukaryotic cells in a sample containing microorganisms such as bacterium and fungus by incubating the sample in a buffer of around pH 9 that contains a non-ionic detergent.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Methods for the rapid detection of the presence or absence of Monkeypox Virus (MPXV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the MPXV F3L gene and the MPXV B21R gene, along with kits are provided that are designed for the detection of MPXV.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
8.
MICROFLUIDIC PARTITION LEAKAGE DETECTION METHODS AND SYSTEMS
System and methods in this disclosure identify leakage from one partition to surrounding partitions. Detecting leakage may include input data describing the location of the partition, the fluorescence intensity, and whether the partition is positive for an analyte. A machine learning model may be trained on an extensive input data set to identify partitions that have leakage or a high probability of leakage. In some embodiments, features used in the machine learning model include values that describe a neighborhood around the partition and not merely the partition itself.
A method for compensating defective partitions of a microfluidic chip and a sample processing system for performing the method are disclosed. The microfluidic chip includes at least one array of partitions. The method includes generating image data of the microfluidic chip by imaging the microfluidic chip with an imaging device, providing a mask for at least one area of partitions to a data processing unit, applying the mask to (a) the image data, (b) at least one feature extracted from the image data, or (c) at least one value extracted from the image data, to generate masked data, and generating an analytical result for the sample using the masked data.
The present invention provides a method comprising the steps of a) providing a nucleic acid comprising 5fC, 5hmC, or 5caC, b) providing one reactant comprising two reactive groups wherein the first reactive group is capable of reacting with the formyl hydroxymethyl or carboxyl group, and the second reactive group is a nucleophilic group, c) reacting said first reactive group with the formyl, hydroxymethyl or carboxyl group thereby resulting in a modified 5fC, 5hmC, or 5caC, d) reacting said second reactive group with the C6 position of said modified 5fC, 5hmC, or 5caC, thereby obtaining a bicyclic or tricyclic molecule comprising a 5,6-di-hydro Cytosine entity, and e) deaminating said 5,6-di-hydro Cytosine entity to a 5,6 di-hydro-Uracil entity.
A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.
The present invention allows for the expansion of multiplexing capabilities of common PCR devices by using fluorogenic PCR probes made of large Stokes shift (LSS) fluorescent dyes. With this approach, no changes of the hardware or software components in the instrument are required.
A biomedical knowledge graph system, the system including a computer database of records, the records comprising nodes of biomedical entities and connections between the entities representing biomedical relationships. One or more processors are programmed and configured to extract data from a plurality of data sources, determine biomedical entities and relationships between the entities based on analyzing the data, wherein analyzing the data comprises searching for predetermined identifiers or patterns in the data. Based on the determined biomedical entities, assigning each biomedical entity to a cluster of biomedical entity types. The one or more processors are configured to identify a context for each of the identified biomedical entities based on the assigned cluster and based on elements of the expression of the biomedical data within which the entity is expressed. Based on the identified context and type of the biomedical entity, incorporating records of nodes and connections between nodes into the knowledge graph, the nodes representing biomedical entities and the connections representing biomedical relationships between the entities structured according to the predefined schema.
Systems and methods are provided for managing patient data. The system integrates medical data from multiple sources to a unified patient database. Structured and unstructured medical data is obtained, enriched (e.g., by designating data field types, standardizing data types or terminology, and the like), and stored to the unified patient database. The data retrieved from the disparate sources is stored to data elements in the unified patient database in a network of connected objects including data about tumor masses, treatments, reports, medical history, and diagnoses. The data in the unified patient database is used to display patient data in user-friendly interface views, including a patient journey view that displays patient data in a chronological fashion organized by data types. The different interface views can be traversed to display patient data originating from disparate sources with ease, to improve the clinical decision making process.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present disclosure relates, in general, to novel and easily accessible fluorescent compounds with large Stokes shift (LSS) and thermostable fluorescence for expanding the multiplexing capabilities of fluorescence-based nucleic acid detection technologies. Moreover, conjugates, probes and FRET pairs comprising these fluorescent compounds as well as methods for amplification and detection of a target nucleic acid utilizing these fluorescent compounds and methods of labeling are also provided.
The present disclosure relates, in general, to the methods for the rapid detection of the presence or absence of Lymphogranuloma Venereum (LGV)-causing serovars of Chlamydia trachomatis in a biological or non-biological sample. The methods can include performing an amplification step, a hybridization step, and a detection step. Furthermore, oligonucleotide primers and probes targeting the pmpH gene for the L serovars of Chlamydia trachomatis, along with kits are provided that are designed for the detection of L serovars.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
18.
FERROCENE LABELLED PRIMERS FOR ELECTROCHEMICAL DETECTION
The present invention provides novel primers in which a ferrocene label is attached to the primer. The ferrocene label is incorporated into the amplification product. When the amplification product incorporating the ferrocene label is denatured, it can bind to a capture probe and the presence or absence of the ferrocene label can be detected via electrochemical detection. The system avoids the use of a signal probe in a sandwich assay as historically used during electrochemical detection.
The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.
Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.
An event chain reaction system (128) is disclosed. The event chain reaction system (128) comprises: —at least one communication interface (156) configured for receiving at least one event stream (160), wherein the event stream (160) comprises at least one sequence of ordered events generated by at least one analytical system (112), wherein each event comprises information about a change in a state of the analytical system (112) and/or any of loaded resources; —at least one chain reaction component (158) comprising at least one chain matching element (162), wherein the chain matching element (162) is configured for recognizing at least one chain on the event stream (160), wherein the chain comprises a set of ordered events to be searched, wherein a first event of the chain defines a start event (166), wherein the chain matching element (162) is configured for identifying the start event (166) in the event stream (160) and, upon identifying the start event (166), the chain matching element (162) is configured for successively determining whether the other events of the chain match to one of the events of the event stream (160), wherein, in case all events of the chain are matched to events of the event stream (160), the chain matching element (162) is configured for triggering at least one reaction, wherein the reaction comprises generating information that a chain was matched and/or issuing a command to at least one component of the analytical system (112), wherein, in case one of the events of the chain is not matched, the chain matching element (162) is configured for resetting to its initial state and waiting for the start event (166). Further, a system (110) for monitoring and/or controlling, a computer implemented method and a computer program for determining at least one feature of at least one component of an analytical system (112), a computer implemented method and a computer program for monitoring and/or controlling at least one feature of at least one component of an analytical system (112) are disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
22.
TEXT ENTRY ASSISTANCE AND CONVERSION TO STRUCTURED MEDICAL DATA
A computer-implemented method is provided. The method comprises: receiving, from a text field of a user interface, input text strings containing medical data; identifying, based on language semantics and grammatical structure, a keyword and one or more data values from the input text strings; providing the keyword as an input to a query of a medical data category database to obtain one or more categories associated with the keyword, the one or more categories including a first category; retrieving, from a template database, a first template associated with the first category, the first template including one or more fixed blocks and one or more variable blocks; inserting a data value corresponding to the keyword into a variable block of the first template to generate a replacement text string; and displaying the replacement text string in place of the input text strings in the text field.
G06F 16/907 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A method for autonomous teach-in of at least one target position of a supply device (120) of a slide imaging apparatus (110) is disclosed. The slide imaging apparatus (110) comprises at least one imaging device (126, 128) configured to generate an image of a sample mounted on a slide (140). The target position is a position on the imaging device (126, 128). The slide imaging apparatus (110) comprises at least one operating system (170) configured for controlling operation of the supply device (120). The method comprises the following steps i) (186) providing at least six pre-defined positions by using the operating system (170); ii) (188) driving the supply device (120) to the six pre-defined positions until colliding with the imaging device (126, 128) by using the operating system (170) and detecting collisions with the imaging device (126, 128); iii) (190) evaluating the detected collisions by using the operating system (170), thereby determining the target position.
G05B 19/425 - Teaching successive positions by numerical control, i.e. commands being entered to control the positioning servo of the tool head or end effector
B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
24.
SYSTEMS AND METHODS FOR ASSESSING BAYS ON DIAGNOSTIC DEVICES
Disclosed are methods, systems and apparatuses in which a diagnostic instrument analyzes data collected over time, and based on that information, disables a bay, suggests a bay, puts a bay on standby or combinations thereof. In some embodiments, the method, system and apparatus allows the diagnostic instrument to have higher validity rates in the field and allows the provider to set up service calls, schedule maintenance and perform remote maintenance, as well as other functions based on the data collected over time.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
25.
CELL CLASSIFICATION USING CENTER EMPHASIS OF A FEATURE MAP
Techniques described herein include, for example, generating a feature map for an input image, generating a plurality of concentric crops of the feature map, and generating an output vector that represents a characteristic of a structure depicted in a center region of the input image using the plurality of concentric crops. Generating the output vector may include, for example, aggregating sets of output features generated from the plurality of concentric crops, and several methods of aggregating are described. Applications to classification of a structure depicted in the center region of the input image are also described.
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
A machine learning and/or deep learning framework was constructed and used to forecast COVID-19 cases and deaths. Multiple open data sources relevant for the pandemic evolution in a geographic area, such as the United States or another country or region, can be processed to extract a plurality of features, such as localized (i.e., county level, city level, regional level, province level, etc.) COVID cases and deaths, demographics and socioeconomic factors, non- medical interventions, and mobility (i.e., from cell phone and/or GPS data).
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
The disclosure provides improved magnetic glass particles for use in nucleic acid capture, enrichment, analysis, and/or purification. Various modifications to the disclosed compositions and methods of using the same, as well as devices and kits are described.
H01F 1/34 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes, all of the foregoing excluding reagents used in connection with demineralized bone for purposes other than diagnostic applications; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific equipment, apparatus and instruments, namely, genome sequencer for scientific, pharmaceutical and medical research purposes; scientific instruments for use in scientific research, namely, nucleic acid sequencers, imaging devices and analyzers; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; laboratory equipment, namely, devices for analysis of nucleic acids and for dna sequencing; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; downloadable software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable software used in analyzing, managing and visualizing dna sequencing data; downloadable software used for preparation of nucleic acids libraries; computer hardware and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes
Disclosed herein are techniques for facilitating a clinical decision for a patient based on identifying a group of patients having similar attributes as the patient. The group of patients can be identified using information from a predictive machine learning model that performs a clinical prediction for the patient. At least some of the attributes of the group of patients can be output to support a clinical decision. The attributes may include, for example, biography data of the patient, results of one or more laboratory tests of the patient, biopsy image data of the patient, molecular biomarkers of the patient, a tumor site of the patient, and a tumor stage of the patient.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for infectious disease surveillance, infection prevention and control, antimicrobial stewardship Software as a service (saas) services featuring software for infectious disease surveillance, infection prevention and control, antimicrobial stewardship and laboratory management
32.
NON-REPLICATIVE TRANSDUCTION PARTICLES WITH ONE OR MORE NON-NATIVE TAIL FIBERS AND TRANSDUCTION PARTICLE-BASED REPORTER SYSTEMS
The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
33.
Method and device for sonicating a biological sample
The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
B01F 35/42 - Clamping or holding arrangements for mounting receptacles on mixing devices
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable software for use therewith sold as a unit
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable software for use therewith sold as a unit
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific and laboratory apparatus, devices and instruments for identifying, sequencing, analyzing, measuring and recording dna or other molecules for non-medical purposes, namely, genome sequencers; laboratory instruments, namely, devices for analysis of nucleic acids, namely, nucleic acid analyzers; laboratory apparatus, namely, nucleic acid sequencers; computer systems and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes; downloadable computer software for use in analyzing, managing and visualizing dna sequencing data; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable operating software sold as a unit for use in laboratory operations Apparatus, devices and instruments for identifying, sequencing, analyzing, measuring and recording dna or other molecules for medical diagnostics purposes, namely, genome sequencers; medical diagnostic and analytical apparatus for medical diagnostic purposes; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, namely, nucleic acid analyzers and nucleic acid sequencers Scientific research and consultancy services related thereto in the fields of genome sequence analysis and reporting; medical research services in the fields of genome sequence analysis and reporting; providing dna screening for scientific research purposes; providing online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory instruments and computer systems for use in science and clinical research; consultancy, information and advisory services in the field of analysis of biomolecules as it relates to dna screening and genome sequence analysis and reporting Medical services for analysis of genetics; genetic testing for medical purposes; nucleic acid based testing for medical purposes; medical services in the field of nucleic acid analysis; medical services in the field of genetic screening
37.
MODIFIED NUCLEOSIDE PHOSPHATES WITH HIGH THERMAL STABILITY
The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside polyphosphates. The present invention also provides for methods for using the modified nucleoside polyphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.
The present invention relates to methods to improve detection of amplification products from Loop-mediated Amplification (LAMP) reactions by the use of nucleotide analogs that form duplex structures that nucleic acid polymerase enzymes do not recognize efficiently.
A computer-implemented method for quality control of at least one digital image of a sample (112) mounted on a slide (114) is proposed. The method comprises the following actions:
a) Providing at least one digital image of the sample (112) mounted on the slide (114) using at least one imaging device (116) of a slide imaging apparatus (110);
b) Determining quality of the digital image by determining sharpness values of subregions of at least one region of interest of the digital image by using at least one edge detection image filter and comparing the sharpness values within the region of interest, wherein the quality of the region of interest is classified depending on the comparison;
c) Generating at least one indication depending on the classification of the quality, wherein actions b) and c) are performed automatically.
G06T 15/00 - 3D [Three Dimensional] image rendering
G06T 5/20 - Image enhancement or restoration by the use of local operators
G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
G06V 10/56 - Extraction of image or video features relating to colour
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
H04N 23/67 - Focus control based on electronic image sensor signals
40.
METHODS FOR CLUSTERING MELTING CURVES TO IDENTIFY GENOTYPES
Automated methods for genotyping melting curves are described. Melting curves are processed and difference matrices are compiled based on the processed matrices. The difference matrices are used to compile a cluster matrix and the cluster matrix is filtered to determine clusters that are used for genotyping the melting curves.
Methods for the rapid detection of the presence or absence of Candida auris (CA) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the CA 5.8 s/ITS2 rRNA gene, along with kits are provided that are designed for the detection of CA.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
42.
COMPUTER-IMPLEMENTED METHOD FOR PERFORMING A CLINICAL PREDICTION
A computer-implemented method for performing a clinical prediction is disclosed. The method comprises the following steps: i) (110) retrieving input data via at least one communication interface (164) of a processing device (166), wherein the input data comprises multiple different modalities of a patient; ii) (114) processing the input data by using the processing device (166), wherein the processing comprises generating embedding modality representations from the input data by using at least one trainable data embedder, wherein the processing comprises combining the embedding modality representations using at least one aggregation network thereby generating the clinical prediction, wherein the aggregation network comprises at least one attention layer and/or at least one transformer layer; and iii) (118) generating an output of the clinical prediction by using the processing device (166).
G06N 3/04 - Architecture, e.g. interconnection topology
G16H 30/00 - ICT specially adapted for the handling or processing of medical images
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying positively charged tags from oligonucleotide probes, bound to target nucleic acids, are produced during PCR by the 5`-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique positively charged tags.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical, biological and biochemical preparations for scientific purposes and for research purposes; in vitro diagnostic reagents for use in research and science; chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; chemical reagents for diagnostic tests and test kits for the determination of genetic information for scientific or research purposes; assays and reagents for use in genetic research; reagents and nucleotides for the sequencing of nucleic acids for scientific or research purposes
45.
AUTOMATED PARALLELIZED PROCESSING OF DECISION-TREE GUIDELINES USING ELECTRONIC RECORD
A machine learning model for traversing a decision tree, the machine learning model trained from a structured data set including a first set of key-value pairs and subject-specific criteria using the key-value pairs. The first set of key-value pairs is transformed into a second set of key-value pairs, which are projected to a subject-specific point within a multi-dimensional space. The decision tree includes decision and leaf nodes. Each leaf node is connected to a root node via a leaf-node-specific trajectory. Each decision node corresponds to a criterion using a value in the second set of key-value pairs. For each leaf node, a leaf-node-specific point within the multi-dimensional space is determined using the leaf-node-specific trajectory, and a similarity score is determined using the leaf-node-specific and subject-specific points. A subset of the leaf nodes is identified using the scores. State or protocol information for each leaf node in the subset is retrieved.
A method for controlling a laboratory system or device comprising at least one pipettor with a pressure sensor, at least one humidity sensor, at least one temperature sensor, and a control unit. The control unit receiving a humidity value from the humidity sensor and a temperature value from the temperature sensor, comparing the pair of humidity and temperature values with a threshold database connected to the control unit, the threshold database comprising, for different pairs of humidity and temperature values, instructions to activate or deactivate an anti droplet control system of the pipettor, determining if the anti droplet system of the pipettor has to be activated or deactivated, activating or deactivating said anti droplet system of the pipettor.
A laboratory system or device, comprising a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably between an open position (O) and a closed position (C), each of the reagent drawers comprising receptacles for a plurality of reagent cartridges (RC1, RC2), and at least two locking mechanisms (4, 5) for respectively locking/unlocking the at least two reagent drawers (2, 3) when in the closed position (C), at least one robotic handler (6) and a control unit (7), wherein the reagent storage area (1) is subdivided in a loading zone (LZ), a storage zone (SZ) and a pipetting zone (PZ), and the reagent storage area (1) further comprises a handling zone (HZ).
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
49.
LABORATORY SYSTEM OR DEVICE WITH INCREASED CONTROLS HANDLING AND METHOD FOR INCREASING CONTROLS HANDLING IN A LABORATORY SYSTEM OR DEVICE
A laboratory system or device comprising a control unit for controlling operation of the system or device, and a storage unit connected to the control unit and containing instruction for each assay type of the control type to be used when running said assay type, and, for each control type, an allocation rule for the control type. The control unit receiving at least one assay order comprising instructions to run at least one assay type on the system or device, determining for the at least one assay type comprised in the at least one assay order, the control type to be used, and the corresponding allocation rule for said control type, scheduling an assay run comprising instructions to include the determined control type based on the determined allocation rule, and controlling the system or device to perform the scheduled assay run.
A method for optimizing handlers operation in a laboratory system or device comprising at least two handlers movably arranged within the system or device in a shared area, and a control unit for controlling the operation of the at least two handlers comprising the following steps: defining for each of the handlers a task, receiving a first operation schedule, the operation schedule comprising a sequence of task to be performed by the handlers, starting operation of the handlers according to the received operation schedule, receiving a second operation schedule, creating an updated operation schedule, and continuing operation of the handlers according to the updated operation schedule.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
51.
A LABORATORY SYSTEM OR DEVICE WITH IMPROVED SECURITY FEATURES AND A METHOD FOR IMPROVING SECURITY IN A LABORATORY SYSTEM OR DEVICE
A method for increasing operational security of a laboratory system or device comprising: a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably along a first axis Y between an open position (O) and a closed position (C) and arranged stacked with respect to a second axis Z perpendicular to the first axis Y, and having each a position sensor (P2, P3) for determining the closed position (C) of the respective reagent drawer (2, 3), at least one robotic handler head (4) movably arranged in the reagent storage area at least along the first axis Y and the second axis Z a control unit (5) configured to control the operation of the robotic handler head (4) and connected to the position sensors (P2, P3), the method comprising the steps of defining for each reagent drawer (2, 3) a first forbidden zone along the first axis Y (Y) and a second forbidden along the second axis Z (Z2, Z3), determining by means of the position sensors (P2, P3) if the reagent storage drawers (2, 3) are in the closed position (C), and control the operation of the handler head (4).
A method for controlling an anti droplet system of a laboratory system or device comprising at least one air displacement pipettor with a pressure sensor and a control unit for controlling operation of the pipettor, the method comprising the following steps controlling the pipettor to be moved such that the pipettor tip is immerged in a fluid to be aspirated, aspirate a predetermined volume of fluid, move the pipettor such that the pipettor tip is emerged from the fluid, continuously monitoring the pressure above the fluid column in the pipettor tip and generating pressure curve over time, and determining if a pressure increase above the fluid column has been detected.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical, biological and biochemical preparations for scientific purposes and for research purposes; in vitro diagnostic reagents for use in research and science; chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; chemical reagents for diagnostic tests and test kits for the determination of genetic information for scientific or research purposes; assays and reagents for use in genetic research; reagents and nucleotides for the sequencing of nucleic acids for scientific or research purposes
54.
INSTRUMENT FOR AUTOMATICALLY DISSECTING A BIOLOGICAL SPECIMEN ON A SLIDE
An instrument (110) for automatically dissecting a biological specimen (112) on a slide (114) is proposed. The instrument (110) comprises at least one imaging system (116). The imaging system (116) comprises at least one camera (118) configured for sequentially imaging at least one image of the slide (114) at a plurality of slide positions. The imaging system (116) com- prises a relay lens system (120) having a fixed focal length. The relay lens system (120) is configured for relaying an impinging light beam (122) from the slide (114) to the camera (118). The instrument (110) further comprises a movable xy-stage (150) configured for setting the slide (114) position. The instrument (110) further comprises at least one processing unit (162) configured for generating a full slide (114) image by stitching the sequentially imaged images of the slide (114). Further, a method for automatically dissecting a biological specimen (112) on a slide (114) is proposed.
A laboratory instrument for processing at least one sample is disclosed. The laboratory instrument includes at least one housing having at least one sample processing device disposed therein, at least one reagent storage compartment reversibly removable from the housing, and at least one safety indicator. The safety indicator is configured for indicating if the reagent storage compartment has been removed from the housing and reinserted into the housing. The laboratory instrument is configured for automatically altering a detectable state of the safety indicator during the process of removing and reinserting the reagent storage compartment.
A method for detection of a bottom of a well of a multiwell plate for a pipetting device is disclosed. The pipetting device includes a pipetting head configured for being coupled to a plurality of pipetting tips. A force sensor configured for measuring a resistance force depending on a force on a pipetting tip exerted by the bottom is used. The method includes measuring the resistance force during movement of one of the pipetting tips from a start position downstream towards the bottom of the well and stopping the movement at a bottom position. The method further includes storing the bottom position together with a corresponding logical position of the well in the multiwell plate in a database. Further disclosed is a pipetting device, a laboratory instrument for processing and/or analyzing a sample and a computer program and a computer-readable storage medium for performing the method.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
G01L 1/20 - Measuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress
A laboratory instrument for processing a sample and a method for automatic surveillance of at least one pipetting procedure of at least one laboratory instrument for processing a sample are disclosed. The laboratory instrument includes at least one pipetting device with at least one pipetting head configured for being coupled to a plurality of pipetting tips. The laboratory instrument further includes a compartment configured for receiving, storing, and/or releasing at least one sample holder. The pipetting device is configured for performing at least one pipetting procedure on the sample holder and the laboratory instrument includes at least one sensor unit configured for gravimetric measuring of the sample holder.
Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, primers and probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).
C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
Digital antimicrobial stewardship program (ASP) systems and methods generate recommendations for a healthcare setting for treating a plurality of patients with a plurality of antibiotics, the recommendations based on medical data of the patients, antiobiogram information that indicate resistance of pathogens to the plurality of antibiotics within the healthcare setting, and a plurality of guidelines related to treatment of certain diseases using the plurality of antibiotics. The recommendation may include prescribing a dosage of an antibiotic or ordering a diagnostic test.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 70/20 - ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
60.
COMPOSITIONS AND METHODS FOR DETECTION OF MYCOPLASMA GENITALIUM
Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided that are designed for the detection of MG.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.
C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
62.
Methods and Compositions for Nucleic Acid Detection
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing DNA, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with DNA sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits comprised of reagents for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with DNA sequencing and genetic analysis Scientific equipment, apparatus and instruments, namely, genome sequencer for scientific, pharmaceutical and medical research purposes; scientific instruments for use in scientific research, namely, nucleic acid sequencers, imaging devices and analyzers; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; laboratory equipment, namely, devices for analysis of nucleic acids and for DNA sequencing; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; downloadable software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable software used in analyzing, managing and visualizing DNA sequencing data; downloadable software used for preparation of nucleic acids libraries; computer hardware and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Clinical or medical diagnostic apparatus and instruments, namely, genome sequencers for clinical or medical diagnostic purposes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purposes; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Clinical or medical diagnostic apparatus and instruments, namely, genome sequencers for clinical or medical diagnostic purposes
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable software for use therewith sold as a unit
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific equipment, apparatus and instruments, namely, genome sequencer for scientific, pharmaceutical and medical research purposes; scientific instruments for use in scientific research, namely, nucleic acid sequencers, imaging devices and analyzers; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; laboratory equipment, namely, devices for analysis of nucleic acids and for dna sequencing; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; downloadable software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable software used in analyzing, managing and visualizing dna sequencing data; downloadable software used for preparation of nucleic acids libraries; computer hardware and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit
68.
MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS
Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A method of verifying multi-modal medical data is proposed. The method comprises: accessing multi-modal medical data of a subject, the multi-modal medical data comprising a medical image of a specimen slide, wherein a specimen in the specimen slide was collected from the subject; generating a prediction pertaining to a biological attribute of the medical image based on the medical image; determining a degree of consistency between the biological attribute of the medical image and other modalities of the multi-modal medical data; and outputting, based on the degree of consistency, an indication of whether the multi-modal medical data contain inconsistency.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
70.
Method to Monitor and Control the Temperature of a Sample Holder of a Laboratory Instrument
A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.
A slide imaging apparatus includes: at least one first imaging device and at least one second imaging device, each configured to generate an image of a sample mounted on a slide; a storage device loadable with a plurality of slides; and a supply device configured to selectively supply the slides from the storage device to the at least one first imaging device or to the at least one second imaging device, wherein the at least one first imaging device and the at least one second imaging device comprise at least one visual indicator configured to indicate an operational status of the at least one first imaging device and the at least one second imaging device, wherein the slide imaging apparatus further comprises at least one vision sensor configured to detect an operational status of the at least one first imaging device and the at least one second imaging device using the at least one visual indicator.
In some embodiments, methods, systems, software and uses are provided for synchronizing medical images displays. An input identifying a region of interest in a first medical image is received. A second region of interest in a second medical image is determined based the first region. The first medical image and a first indication of the first region are displayed in a first viewport of a GUI. The second medical image and a second indication of the second region are displayed in a second viewport of the GUI. A display adjustment input is received to adjust the displaying of one of the first or second region of interest. Based on the display adjustment input and the correspondence information, an adjustment of the displaying of the first region of interest in the first viewport and an adjustment of the displaying of the second region of interest in the second viewport is implemented.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific and laboratory apparatus, devices and instruments for identifying, sequencing, analyzing, measuring and recording dna or other molecules for non-medical purposes, namely, genome sequencers; laboratory instruments, namely, devices for analysis of nucleic acids, namely, nucleic acid analyzers; laboratory apparatus, namely, nucleic acid sequencers; computer systems and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes; downloadable computer software for use in analyzing, managing and visualizing dna sequencing data Apparatus, devices and instruments for identifying, sequencing, analyzing, measuring and recording dna or other molecules for medical diagnostics purposes, namely, genome sequencers; medical diagnostic and analytical apparatus for medical diagnostic purposes; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, namely, nucleic acid analyzers and nucleic acid sequencers Scientific research and consultancy services related thereto in the fields of genome sequence analysis and reporting; medical research services in the fields of genome sequence analysis and reporting; providing dna screening for scientific research purposes; providing online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory instruments and computer systems for use in science and clinical research; consultancy, information and advisory services in the field of analysis of biomolecules as it relates to dna screening and genome sequence analysis and reporting Medical services for analysis of genetics; genetic testing for medical purposes; nucleic acid based testing for medical purposes; medical services in the field of nucleic acid analysis; medical services in the field of genetic screening
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific equipment, apparatus and instruments, namely, genome sequencer for scientific, pharmaceutical and medical research purposes; scientific instruments for use in scientific research, namely, nucleic acid sequencers, imaging devices and analyzers; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; laboratory equipment, namely, devices for analysis of nucleic acids and for dna sequencing; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable computer software for use therewith sold as a unit Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purposes, excluding scientific equipment, apparatus and instruments in the veterinary field; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Clinical or medical diagnostic apparatus and instruments, namely, genome sequencers for clinical or medical diagnostic purposes, excluding clinical or medical diagnostic apparatus and instruments in the veterinary field
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific equipment, apparatus and instruments, namely, genome sequencer for scientific, pharmaceutical and medical research purposes; scientific instruments for use in scientific research, namely, nucleic acid sequencers, imaging devices and analyzers; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; laboratory equipment, namely, devices for analysis of nucleic acids and for dna sequencing; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable computer software for use therewith sold as a unit Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
77.
COMPOSITIONS AND METHODS FOR DETECTING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
Methods for the rapid detection of the presence or absence of mecA- and/or mecC-containing Staphylococcus aureus (mecA/mecC-MRSA) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the genes for mecA-MRSA and mecC-5 MRSA, along with kits are provided that are designed for the detection of mecA/mecC-MRSA.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
The present invention provides for water-soluble mono- and dicationic fluorescent dyes with the latter exhibiting stable fluorescence at elevated temperatures. The present invention also provides for methods for the production of the fluorescent dyes and for using these dyes in biological assays such as multiplexing qPCR and tissue staining.
Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
The present invention is directed to a foldable transport container suitable to receive and hold multiple plates with samples in it. The container is comfortable to load, transport and unload. The invention also relates to a strip of material for providing such a foldable transport container. Finally the invention relates to a method for assembling such a foldable container.
B65D 5/20 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper by folding-up portions connected to a central panel from all sides to form a container body, e.g. of tray-like form
B65D 5/30 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper by folding-up portions connected to a central panel from all sides to form a container body, e.g. of tray-like form with tongue-and-slot or like connections between sides and extensions of other sides
B65D 5/42 - Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper - Details of containers or of foldable or erectable container blanks
A slide imaging apparatus includes: at least one imaging device configured to generate an image of a sample mounted on a slide, wherein the imaging device comprises an operating button; a storage device loadable with a plurality of slides and configured to store the slides; and a supply device configured to supply the slides from the storage device to the imaging device, wherein the supply device is configured to press the operating button.
The present invention describes methods for temperature multiplexed PCR for detection and quantitation of target nucleic acids with increased sensitivity. The methods are performed by contacting the sample with probes designed for temperature multiplexed PCR, measuring the fluorescence at multiple temperatures, subtracting signals to obtain calculated signals for each target of interest. Furthermore, the methods comprise obtaining a baseline of the first fluorescent signal, and adjusting the calculated signals using the obtained baseline of the first fluorescent signal to obtain a baseline shifted calculated signals.
In one embodiment, a method includes indexing a whole slide image dataset to generate one or more dataset embeddings corresponding to one or more respective regions of one or more whole slide images. Each dataset embedding includes a feature vector mapping the respective region to a feature embedding space. The method includes accessing a query image and generating an embedding for the query image that includes a feature vector mapping the query image to the feature embedding space. The method includes identifying result tiles by comparing the embedding for the query image to one or more of the dataset embeddings. The comparison is based on a distance between the embedding for the query image and the one or more of the dataset embeddings in the feature embedding space. The method includes generating a user interface including a display of the result tiles
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
90.
INSTRUMENT FOR PROCESSING CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM
In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.
Techniques for patient data management include obtaining medical history data of patients from a database, the medical history data including a history of one or more diagnosis events, one or more treatment events, and a clinical outcome event for each patient of the patients. For each patient, based on the medical history data, a computing system generates a patient pathway that includes a graph including nodes of one or more diagnosis events, the one or more treatment events, and the clinical outcome event. The computing system receives, via an interface, one or more criteria to select a subset of the patient pathways of the patients. The computing system selects, based on the one or more criteria, graphs representing the subset of the patient pathways. The computing system aggregates the subset of the patient pathways into a merged graph. The computing system displays the merged graph in the interface.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
94.
COMPOSITIONS AND METHODS FOR RAPID IDENTIFICATION AND PHENOTYPIC ANTIMICROBIAL SUSCEPTIBILITY TESTING OF BACTERIA AND FUNGI
The present invention relates to compositions and methods for the use of polymerase chain reaction (PCR) as a reporter assay for rapid and simultaneous bacterial identification and phenotype testing for antimicrobial susceptibility (AST). The current invention uses a strategy that has shown the ability for multiplexing and for handling polymicrobial samples for antimicrobial susceptibility testing.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
95.
Display screen or portion thereof with animated graphical user interface for symptom tracking of covid-19
The present invention relates to methods and compositions for performing quantitative polymerase chain reaction (qPCR) to screen for previously undiscovered inducible prophages from various bacterial strains. The present invention also relates to methods for performing qPCR to identify inducible prophages for creation of functional non-replicative transcription particles (NRTPs).
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
97.
COMPOSITIONS AND METHODS FOR DETECTING HEPATITIS DELTA VIRUS BY A DUAL-TARGET ASSAY
Methods for the rapid detection of the presence or absence of Hepatitis Delta Virus (HDV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the HDV Ribozyme domain and the HDV Hepatitis Delta Antigen (HDAg) gene, along with kits are provided that are designed for the detection of HDV.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
A device for the mixing fluid media. The device is a bladeless mixer. The device comprises a hollow body with at least a single inlet opening in its bottom and at least a single outflow region in its side. The device is rotated at a speed at which the media due to centrifugal forces enters the device's hollow cavity via the inflow opening or unit. The media is discharged from the cavity through one or more outlet units or openings in the sides or in the top of the device. During mixing the media does not rise above the level of the undisturbed media.
B01F 27/2123 - Shafts with both stirring means and feeding or discharging means
B01F 27/81 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis the stirrers having central axial inflow and substantially radial outflow
B01F 27/94 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with rotary cylinders or cones
99.
DETECTION OF TARGET NUCLEIC ACID BY SOLID-PHASE MOLOGRAPHY
The present invention describes methods for performing real-time PCR for detection and quantitation of target nucleic acids using tagged oligonucleotide probes and solid-phase molography.
In one example, a method being performed by a computer system comprises: receiving an image file containing a pathology report; performing an image recognition operation on the image file to extract input text strings; detecting, using a natural language processing (NLP) model, entities from the input text strings, each entity including a label and a value; extracting, using the NLP model, the values of the entities from the input text strings; converting, based on a mapping table that maps entities and values to pre-determined terminologies, the values of at least some of the entities to the corresponding pre-determined terminologies; and generating a post-processed pathology report including the entities detected from the input text strings and the corresponding pre-determined terminologies.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G06V 30/30 - Character recognition based on the type of data
