The present invention relates to a filling apparatus for filling a reusable reservoir of a medical dispensing device, the filling apparatus comprises a receiving portion for a reusable reservoir, a supply container for containing a liquid medication, a first connection port for fluidly connecting an inner volume of the reusable reservoir with the supply container, and a sterilization device that is configured for sterilizing the inner volume of the reusable reservoir. In order to provide an improved sterilization, the filling apparatus further comprises a discharging device for discharging deposit from the inner volume of the inner volume, wherein the sterilization device comprises a radiation source for providing a radiation for sterilizing the reusable reservoir. The reusable reservoir is housed in a radiation chamber.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software; downloadable mobile applications.. Medical apparatus and instruments.. Data collection in the field of health care.. Platform as a Service [PaaS]; scientific research services for medical purposes; software as a service (SAAS).. Medical services..
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Control solutions for medical and clinical use for performing quality checks on blood glucose monitors and diagnostic test strips Diagnostic test strips for determining the level of glucose in blood for medical and clinical use Blood glucose monitors for medical diagnostic use; and blood glucose monitoring kit comprised primarily of a blood glucose monitor and diagnostic test strips, all for medical diagnostic use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software, computer hardware and downloadable mobile
applications in the field of diabetes. Medical apparatus and instruments in the field of diabetes. Printed matter. Data collection services in the field of diabetes. Education and training in the field of diabetes. Platform as a service [PaaS]; scientific research for
medical purposes. Medical services in the field of diabetes.
5.
A METHOD AND AN ANALYTE SENSOR SYSTEM FOR DETECTING AT LEAST ONE ANALYTE
The present invention relates to a method (200) of continuously in vivo detecting at least one analyte in a bodily fluid over a time span, an analyte sensor system (100) for in vivo continuously detecting at least one analyte in a bodily fluid over a measurement time span, a computer program and a computer-readable storage medium. The method (200) makes use of at least one analyte sensor (102) comprising at least one working electrode (104), configured for performing at least one electrochemical detection reaction with the analyte, and at least one further electrode (106), the further electrode (106) comprising at least one redox material composition, the redox material composition comprising silver and silver chloride, the method (200) comprising the following steps: monitoring at least one standard sensor signal (132) derived by using the analyte sensor (102) in a standard operation mode, comparing the standard sensor signal (132) with at least one threshold, thereby determining if a change of an operation mode of the analyte sensor (102) from the standard operation mode into an economy operation mode is required.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1495 - Calibrating or testing in vivo probes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer software, computer hardware and downloadable mobile applications in the field of diabetes.
(2) Medical apparatus and instruments in the field of diabetes.
(3) Printed matter. (1) Data collection services in the field of diabetes.
(2) Education and training in the field of diabetes.
(3) Platform as a service [PaaS]; scientific research for medical purposes.
(4) Medical services in the field of diabetes.
7.
MEDICAL INFUSION DEVICE COMPRISING A LEAKAGE DETERMINING MODULE
The present invention relates to a medical infusion device comprising a reservoir for holding a liquid medicament, a cannula assembly, a fluid line, a drive mechanism, a dispensing member for dispensing medicament from reservoir through the fluid line and the cannula assembly, and a leakage determining module. For a more convenient determination of leakage of liquid medicament, the leakage determining module comprises an electronic probe that is configured for receiving odor molecules and/or flavor molecules of the liquid medicament and in that the leakage determining module further comprises evaluation electronics that is configured to determine presence of odor and/or flavor of the liquid medicament based on readings of the at least one electronic probe.
The present disclosure refers to computer-implemented method and healthcare management system for providing a personalized healthcare parameter. The method is comprising the following: providing a healthcare application (20), and an interface application (25) running in a data processing component having a plurality of data processors; submitting, from the healthcare application (20) to the interface application (25), a service request indicative of a request for determining a first personalized healthcare parameter, the first personalized healthcare parameter being indicative of a first healthcare condition of the patient; in response to receiving the service request, generating a first input data request by the interface application (25); providing the first input data request to a first service application (26a) from a plurality of service applications, wherein each of the service applications (26) is configured to determine, for a patient, a respective personalized healthcare parameter in response to receiving respective personalized input data, and the first service application (26a) is configured to determine the first personalized healthcare parameter; receiving first input data information in the interface application (25), the first input data information being indicative of a data specification of first input data required by the first service application (26a) for determining the first personalized healthcare parameter; receiving the first input data information in the healthcare application (20); generating first personalized input data in the healthcare application (20), the first personalized input data being generated according to the first input data information; receiving the first personalized healthcare parameter in the healthcare application (20), wherein the first personalized healthcare parameter was determined in response to receiving the first personalized input data in the first service application (26a), such determining comprising processing the first personalized input data; and outputting the first personalized healthcare parameter to a receiving device (27; 28) connected to the data processing component (2).
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Analyte sensor morphology The invention relates to an analyte sensor for use in medical devices for measuring analyte data in an analyte carrying fluid, in particular for measuring glucose data, comprising: a first electrode (101) being a working electrode, a second electrode, a substrate (100) carrying the first electrode and the second electrode, at least one membrane (104) which at least partially covers the first electrode (101), wherein the at least one membrane (101) comprises a membrane material that is impermeable to the analyte carrying fluid and/or the analyte, wherein the at least one membrane comprises at least one opening (107), and wherein the at least one membrane (104) is configured for controlling the flux of the analyte carrying fluid and/or the analyte to the first electrode (101) via the at least one opening (107).
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
10.
METHOD OF DETERMINING A FINAL NUMERICAL ANALYTE RESULT VALUE CORRESPONDING TO A CONCENTRATION OF AN ANALYTE IN A BODILY FLUID USING A MOBILE DEVICE
A method of determining an analyte concentration in a bodily fluid using a mobile device with a camera, as well as a corresponding computer program, a non-transitory computer- readable storage medium with corresponding instructions, a corresponding mobile device, and a corresponding kit. The method comprises step a: determining a numerical analyte result value from an image of a color formation of a reagent test region, step b: displaying the numerical analyte result value and/or a corresponding analyte value range and/or a corresponding message, wherein in a step c) after step a) and before step b) an upper bias is added to the numerical analyte result value if it exceeds an upper threshold value, or a lower bias is subtracted if it falls below a lower threshold value, or it is kept unchanged it neither threshold value is passed.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
11.
METHOD OF INDIVIDUALIZING ANALYTE VALUE RANGES USED TO CATEGORIZE A CONCENTRATION OF AN ANALYTE
A method of individualizing analyte value ranges used to categorize a concentration of an analyte in a sample of a bodily fluid of a subject applied to a reagent test region and determined using a mobile device having a processing device, as well as a corresponding computer program, a non-transitory computer-readable storage medium with corresponding instructions, a corresponding mobile device, and a corresponding kit. The method comprises the steps of determining a numerical analyte result value from an image of a color formation of the reagent test region, attributing the numerical analyte result value to a corresponding analyte value range, and adapting one or more range limit values based on a plurality of numerical analyte result values previously determined for different samples of the subject's bodily fluid taken at different points in time.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
12.
SYSTEM AND METHOD FOR ADAPTIVE GENERATION OF GRAPHICAL DATA OF A TREATMENT HISTORY
A method for generating graphical data of a patient treatment history includes receiving medical data for the patient corresponding to patient visits to a healthcare provider and generating graphical data corresponding to a timeline view of the patient visits. The generated graphical data include first and second graphical elements corresponding to first and second diagnoses based on the medical data during a current patient visit and a prior patient visit. Each graphical element includes a graphical indicator of a diagnosis for a medical condition and at least one graphical sub-element, the at least one graphical sub-element being relevant to a physiological parameter selected from the medical data and related to the diagnosis. The method includes generating a first graphical connector between the second graphical element and the first graphical element, to indicate a progression of time between patient visits in the timeline view.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
13.
SYSTEM AND METHOD FOR ADAPTIVE GENERATION OF GRAPHICAL DATA OF PREDICTED DIAGNOSES
A method for generating a user interface of predicted disease progressions includes receiving medical data corresponding to patient visits to a healthcare provider, generating a diagnosis for the patient based on the medical data, and generating a predicted diagnosis for a future condition of the patient based upon the diagnosis, and a predictive model. The method further includes generating a timeline view of a diagnosis in the current patient visit and the predicted diagnosis. The graphical element of the diagnosis and the predicted diagnosis both include a graphical indicator of a diagnosis and at least one graphical sub-element of a physiological parameter relevant to the diagnosis. The method further includes generating a graphical connector between the graphical elements to indicate progression of time between a first time of the current patient visit and a second time.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
An insertion system (114) comprising at least one screw coupling (118) configured for coupling at least one first element (110) and at least one second element (112) of the insertion system (114) is disclosed. The screw coupling (118) is configured such that the first element (110) and the second element (112) are assembled without rotational movement. The screw coupling (118) comprises - at least one radially flexible part (120) configured for radial movement and/or deformation when assembling the first element (110) and the second element (112), wherein the radially flexible part (120) is a part of the first element (110) or second element (112); - elastic means (122) configured for applying a force in an axial direction (124) to the screw coupling (118), wherein the elastic means (122) are preloadable in the axial direction (124) during assembly of the insertion system (114).
Insertion device, Insertion system and method for inserting a medical device Insertion device for at least partially inserting a medical device such as an analyte sensor through the skin of a subject, the insertion device having a proximal end to be put in contact with the skin and a distal end opposite to the proximal end, the insertion device comprising: a guide sleeve being provided at the proximal end and to be placed in contact with the skin for an insertion process; a cap being provided at distal end, which can be pressed on to carry out at least part of the insertion process while moving in the direction of the proximal end; an inserter sleeve provided at least partially within the guide sleeve and/or the cap and being provided with a holder for the medical device and the inserter sleeve being moveable with respect to the guide sleeve; a retractor configured to retract a portion provided with the medical device, the retractor being moveable along a movement path; an elastic element such as a spring, which can bias the retractor towards the distal end along the movement path; a retractor control element which controls the movement of the retractor by blocking or freeing the movement of the retractor along the movement path and which is itself moveable such as rotatable with respect to the retractor. The invention further refers to an insertion system and an insertion method.
The present invention relates to an infusion delivery device comprising a reservoir that is configured for containing a liquid medicament, a dispensing member that is moveably arranged within the reservoir for dispensing liquid medicament out of the reservoir through an outlet of the reservoir, an actuation member that is configured for moving the dispensing member within the reservoir, and a controller that is configured for controlling the movement of the dispensing member within the reservoir by the actuation member, wherein the controller is further configured to determine an occlusion hindering the dispensing of liquid medicament out of the reservoir and that is configured to provide a control signal to the actuation member, upon determining an occlusion, to move the dispensing member in a reverse direction about a displacement distance. In order to prevent an overdosing or underdosing in case of an occlusion, the displacement distance is a model-based displacement distance.
The invention relates to an analyte sensor (100) for use in medical devices for measuring analyte data, in particular for measuring glucose data, comprising: a power source (102) for providing electrical power to the analyte sensor (100), an enclosure (101) of the analyte sensor, a sensor circuit (103) powered by said power source and comprising two electrodes (105, 106), wherein said electrodes (105, 106) each have a first portion (105a, 106a) that lies inside the enclosure (101) and a second portion (105b, 105b) that lies outside of the enclosure (101), at least one protection unit (107), wherein said protection unit (107) is electrically coupled to the first portion (105a, 106a) of each of the two electrodes (105, 106) that is located inside the enclosure (101), and wherein said at least one protection unit (107) is configured to short-circuit the two electrodes (105, 106) in case a voltage signal from the sensor circuit (103) applied to the electrodes (105, 106) exceeds a predetermined voltage threshold. The invention further relates to a method (300) for operating an analyte sensor.
The invention relates to a body-wearable medical device with a medical device housing comprising a transcutaneous element that is configured for being at least partially inserted into a patient's body at an insertion site during use of the body-wearable medical device, and a base portion that is configured for reversibly attaching the body-wearable medical device during its use to a patient's skin, wherein the base portion comprises a first side that during use of the body-wearable medical device faces the patient's body and that comprises an adhesive for adhering the body-wearable medical device to a patient's skin. For reducing a likelihood of a contamination by bodily fluid flowing out of the insertion lesion, the base portion on its first side further comprises a superabsorbent substance and at least one fluid channel, the at least one fluid channel being configured to guide bodily fluid from the insertion site to the superabsorbent substance.
The present invention relates to a body-wearable medical device comprising a first housing portion and a second housing portion, the first housing portion having a female portion and the second housing portion having a male portion, the male portion is at least partially inserted into the female portion thereby defining a circumferential clearance gap, wherein a circumferential sealing element is arranged in the circumferential clearance gap between the female portion and the male portion. In order to provide a body-wearable medical device comprising an improved sealing that is less prone to failure by stress and forces exerting on the body-wearable medical device, the female portion and the male portion are fixed to each other by a circumferential fixation glue that is arranged in the circumferential clearance gap between the female portion and the male portion next to the circumferential sealing element.
Methods and devices for determining the concentration of at least one analyte in a bodily fluid A determination method of determining a color expectation range (132) for assessing the plausibility of a color formation value obtained in an analytical measurement based on a color formation reaction and a measurement method of performing an analytical measurement based on a color formation reaction by using a mobile device (112) having a camera (114) and a processor (130) are disclosed. Further disclosed are a determination system (110) for determining a color expectation range (132) for assessing the plausibility of a color formation value obtained in an analytical measurement based on a color formation reaction. The determination system comprises a training set of optical test strips (116) having a reagent test region (120). At least two of the training optical test strips are non-corrupted (122) and at least two are corrupted (124).
A determination method of determining at least one color expectation range (128) for assessing the plausibility of an assumed reaction time value used in an analytical measurement based on a color formation reaction and a measurement method of performing an analytical measurement based on a color formation reaction by using a mobile device (112) having a camera (114) and a processor (126) are disclosed. Further disclosed are a determination system (110) for determining at least one color expectation range (128) for assessing the plausibility of an assumed reaction time value used in an analytical measurement based on a color formation reaction, a mobile device (112) having at least one camera (114) and at least one processor (130), a kit (134) for determining the concentration of at least one analyte in a sample of a bodily fluid (128) comprising said mobile device (112) as well as computer programs and computer-readable storage media comprising instructions which, when performed on the respective device cause the device to perform the determination method and/or the measurement method.
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
22.
METHODS AND DEVICES FOR PERFORMING AN ANALYTICAL MEASUREMENT
vTR, limvTRvRF, minvTR, limvRF, minvTR, limvTR, maxvTR, max) for reagent test regions (114) of non-corrupted optical test strips (116). Further, a measurement method of performing an analytical measurement based on a color formation reaction by using a mobile device (122) having a camera (124) and a processor (138), a determination system (110), a mobile device (122), computer programs and computer-readable storage media are disclosed.
The invention refers to an electronic circuit configured to operate an analyte sensor, such as a glucose sensor, the circuit having at least a first and a second electrical connection configured to be connected to a first and a second electrode of the analyte sensor respectively, wherein the electronic circuit has a voltage source and a common potential conductor section electrically provided on a potential of a pole of the voltage source, wherein with the voltage source an electric potential different to the potential of the common potential conductor section can be provided to the first electrical connection; and wherein the second electrical connection is connected to the common potential conductor section through one or more common potential connection paths and wherein none of the common potential connection paths connects the second electrical connection to the common potential conductor section through fewer than three or more series-connected electronic components.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer software, downloadable mobile applications, downloadable computer software applications and downloadable computer software platforms, all for use with devices for monitoring blood glucose levels by individuals with diabetes, namely, for enabling users to link blood glucose monitors to the foregoing software, mobile applications and software platforms, for collecting, recording, storing, tracking, managing and analyzing user healthcare data, for analyzing and evaluating user healthcare data to provide users with predictions about potential diabetes medical conditions and outcomes, for enabling users to input and track data and progress related to their diabetes management activities, and for transmitting user healthcare data to healthcare providers Medical instruments and apparatus for use in the field of diabetes, namely, blood glucose meters, devices for monitoring blood glucose levels, and medical test kits for diabetes monitoring Printed matter, namely, instructional and teaching materials related to diabetes electronic data collection services for business purposes in the field of diabetes healthcare Education and teaching, namely, providing classes, workshops and seminars in the field of diabetes management, publication of printed products, namely, books, brochures, leaflets, and journals related to the field of diabetes for professionals and patients Providing online non-downloadable data collection software for collecting data from medical and consumer devices, for use by healthcare providers and individuals with diabetes medical advice in the field of diabetes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software, Computer hardware and downloadable mobile applications in the field of diabetes.. Medical apparatus and instruments in the field of diabetes.. Printed matters.. Data collection services in the field of diabetes.. Education and training in the field of diabetes.. Platform as a Service [PaaS]; scientific research for medical purposes.. Medical services in the field of diabetes..
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software and computer hardware; downloadable mobile applications.. Medical apparatus and instruments.. Data collection in the field of health care and medicine.. Platform as a Service [PaaS]; Scientific research for medical purposes.. Medical service..
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software and computer hardware; downloadable mobile applications.. Medical apparatus and instruments.. Data collection in the field of health care and medicine.. Platform as a Service [PaaS]; Scientific research for medical purposes.. Medical service..
The present invention relates to a computer-implemented method, a mobile device, and a computer program, for managing medical data such as, e.g., a glucose concentrations, by an electronic disease management system comprising detecting a change of the local time between generation of a first set of medical data and a second set of medical data.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G01N 33/487 - Physical analysis of biological material of liquid biological material
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
29.
ANALYTE SENSOR AND METHOD FOR MANUFACTURING AN ANALYTE SENSOR
The disclosure relates to an analyte sensor comprising a substrate, at least one working electrode, at least one second electrode and a membrane, wherein the membrane is located on top of the second electrode, and the second electrode has at least one first silver layer and at least one second silver layer which partially overlap with one another and have the same composition. The first and second silver layers intersect with one another to form a + or a T shape design. The sensor includes at least one exposed area of the first silver layer disposed on the exterior of the sensor to provide for direct contact with body fluid when implanted. The disclosure further relates to a process for manufacturing an analyte sensor.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
The present invention provides analyte sensor system which comprises a body wearable analyte sensor device, comprising a transcutaneous analyte sensor, a housing comprising a lower side which can be attached to the skin of a patient, a IR temperature sensor which is configured to detect the temperature of the lower side of the housing or to detect the temperature of the skin, and wherein the IR temperature sensor faces without contact the lower side of the housing, and a processor configured to receive signals from the analyte sensor and from the IR temperature sensor. In addition, a method of determing an analyte concentration using an analyte sensor system (1) of the invention is provided.
Systems and methods for measuring an analyte include devices configured to perform an analyte testing operation. The devices include a wearable electronic device and a remote device operatively connected to each other and each having a processor, the processors cooperating with each other in the execution of program instructions to measure an analyte. The wearable electronic device includes a camera configured to generate a video stream, which is analyzed to identify missing test components, to identify the application of a body fluid on a test strip where the sample undergoes changes in one or more optical properties, the image of which is analyzed to determine a level of the analyte. The wearable electronic device further includes a head-up display (HUD) for providing output messages to the user relating to the performance and status of the analyte testing operation.
A method for measuring an analyte includes identifying a test strip in a video stream generated by a camera based on at least one registration mark associated with the test strip depicted in the video stream, identifying application of a fluid dose to a deposit site formed on the test strip based on the video stream, activating a timer in response to the identification of the application of the fluid dose, generating at least one optical measurement of a reagent located at a measurement site on the test strip, and generating a measurement of an analyte in the fluid dose based on the at least one optical measurement of the reagent only in response to the at least one optical measurement being generated after a predetermined minimum time period has elapsed and prior to a predetermined maximum time period elapsing subsequent to the activating of the timer.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
33.
SYSTEM AND METHOD FOR AUTOMATED OPTICAL ANALYTE MEASUREMENTS VIA WEARABLE SMART DEVICES
Systems and methods for measuring an analyte include devices configured to perform an analyte testing operation. The devices include a wearable electronic device and a remote device operatively connected to each other and each having a processor, the processors cooperating with each other in the execution of program instructions configured to direct the devices in the performance of the analyte testing operation. The wearable electronic device includes a camera configured to generate a video stream and one or more images relating to a user removing a test strip from a vial, producing a bodily fluid sample, and applying the sample to a deposit site of the test strip where the sample undergoes changes in one or more optical properties, the image of which is analyzed to determine a level of the analyte. The wearable electronic device further includes a head-up display (HUD) for providing output messages to the user relating to the performance and status of the analyte testing operation.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
34.
ENHANCED METHOD FOR THE DETERMINATION OF AN ANALYTE CONCENTRATION IN BODILY FLUID
The present invention relates to an analytical method for determining a concentration of an analyte in a bodily fluid by using a mobile device having at least one camera, at least one lidar sensor, at least one processor, and at least one display, wherein the at least one camera and the at least one lidar sensor comprise an at least partially overlapping field of view, the method comprising the following steps: a) providing at least one object, the at least one object being selected from the list comprising: an optical test element having a reagent test region, a color reference card having a reagent test region, a color reference card adapted to be associated with an optical test element having a reagent test region; wherein the reagent test region is adapted for application of a sample of the bodily fluid, and wherein the reagent test region is adapted to undergo, at least partially, a color formation reaction when the sample of the bodily fluid is applied to the reagent test region; b1) prompting, by the display, a user to apply a drop of the bodily fluid to the reagent test region and/or prompting, by the display, a user to confirm application of a drop of the bodily fluid to the reagent test region; b2) prompting, by the display, the user to provide the at least one object within the at least partially overlapping field of view of the at least one camera and the at least one lidar sensor; c) generating, by the processor, a lidar measurement data set at least for the object by receiving output data from the at least one lidar sensor, the lidar measurement data set representing a three-dimensional structure of at least a part of the object; d) comparing, by the processor, the lidar measurement data set from step c) to a pre-generated lidar data set for the object, the pre-generated lidar data set representing a three-dimensional structure of the entire object, thereby obtaining an item of information on a degree of congruence of the lidar measurement data set and the pre-generated lidar data set; and e1) if the item of information from step d) indicates a degree of congruence equal to or above a pre-determined minimum degree of congruence: capturing, by the at least one camera, a measurement image of at least a part of the reagent test region having the sample of the bodily fluid applied thereto, and determining the concentration of the analyte in the bodily fluid based at least on the measurement image captured; or e2) if the item of information from step d) indicates a degree of congruence below a pre-determined minimum degree of congruence: - at least temporarily not allowing the capturing, by the at least one camera, of a measurement image of at least a part of the reagent test region having the sample of the bodily fluid applied thereto; and/or - indicating, by the display, a warning to the user; and/or - indicating, by the display, instractions to the user to take some appropriate action in order to capture, by the at least one camera, a measurement image of at least a part of the reagent test region having the sample of the bodily fluid applied thereto.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01S 17/88 - Lidar systems, specially adapted for specific applications
The present invention relates to an analyte sensor comprising a substrate, a first conductive material, a second conductive material, a first layer and a second layer, wherein the first and the second layer, in-dependently of one another have a varying thickness along the length of the substrate and/or are located on the substrate as at least two fields separate from one another. The present invention further-more relates to a method for manufacturing the analyte sensor and an analyte sensor system comprising the analyte sensor.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
The present invention relates to an analyte sensor comprising a substrate, at least one first electrode, at least one second electrode and at least one protective layer covering the at least one second electrode. The present invention further relates to a process for manufacturing the inventive analyte sensor as well as to an analyte sensor system comprising an analyte sensor according to the present invention and an electronics unit. The analyte sensor according to the present invention may mainly be used for conducting analyte measurements in a body fluid of a user.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
37.
METHODS AND DEVICES FOR CONTROLLING AUTO WHITE BALANCE SETTINGS OF A MOBILE DEVICE FOR A COLOR BASED MEASUREMENT USING A COLOR REFERENCE CARD
A method of controlling auto white balance settings of a mobile device with a camera and preset auto white balance modes for performing a color based measurement comprising the steps of capturing an image of at least part of one or more gray fields of a color reference card, determining for a region of interest within the image a number of gray fields for which the color information for a first and a second color shows overexposure as a first and second overexposure-number, respectively, the first color relating to a smaller wavelength than the second color, and re-capturing the image with a warmer white balance mode if the first overexposure number is greater than the second overexposure number or re-capturing the image with a cooler white balance mode if the first overexposure number is smaller than the second overexposure number.
G09G 5/02 - Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators characterised by the way in which colour is displayed
G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/29 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
The present invention relates to a manual insertion aid for inserting a cannula unit into a cannula holder. The manual insertion aid comprises a handle and two jaws projecting from the handle and forming a receiving opening that is configured for engaging with a cannula unit. In order to provide a simple and lightweight insertion aid, the minimum clearance between the two jaws is greater than or equal to 1.5 mm and smaller than or equal to 7 mm, and wherein the maximum projecting length of each of the two jaws from the handle is greater than or equal to 4 mm and smaller than or equal to 18 mm.
A device comprising a body part that is attachable to a body of a patient, wherein the body part comprises a receiving opening through which a functional element can be reversibly introduced into a body of a patient by means of an inserting device, like a needle, wherein the body part comprises a sealing member that is adapted to seal at least a part of the receiving opening after removal of the inserting device.
A device for transcutaneous insertion comprising a flexible insertion piece (1) for transcutaneous insertion, characterized in the flexible insertion piece (1) comprising a deformation measurement device for detecting one or more deformation signals, a transcutaneous insertion system, comprising such a device for transcutaneous insertion and a method of detecting deformation of at least a part of the insertion piece of a device for transcutaneous insertion.
An analyte sensor (110) for determining at least one analyte and a method (140) for producing an analyte sensor (110) are disclosed. The analyte sensor (110) comprises: - a substrate (112); - a working electrode (118) and a conductive layer (124) located on different sites on the substrate (112); - a silver comprising layer (126) partially covering the conductive layer (124); and - a protective layer (128), which • comprises at least one electrically conductive material; and • covers the silver comprising layer (126) apart from at least one at least one hole that provides access for at least one body fluid comprising the at least one analyte to the silver comprising layer (126). Although the analyte sensor (110) as disclosed herein has a reduced overall size, sufficient space is, nevertheless, provided for the silver comprising layer (126) coated by the protective layer (128) while, concurrently, further sufficient space remains which is neither coated by the silver comprising layer (126) nor by the protective layer (128).
e.g.,e.g., a mobile device) may determine a first notification visibility level for the user health-related event based on a context. The user device may receive data associated with the user health-related event. The user device may determine an adherence level for the user health-related event based on the data associated with the user health-related event. The user device may determine a second notification visibility level for the user health-related event based on comparison of the adherence level to a plurality of predefined adherence thresholds. The user device may communicate, using the second notification visibility level, a notification associated with the user health-related event via the user device upon detection of a triggering event. The user device may group, based on the context, one or more user health-related events into a notification group.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G08B 21/24 - Reminder alarms, e.g. anti-loss alarms
G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
The invention relates to a system, a sensor and a method for measuring an analyte concentration using an electrochemical analyte sensor, the analyte sensor comprising a first electrode and a second electrode, the first electrode being configured to react with the analyte for generating an electrical signal, wherein the method comprises: applying (201) a modulated voltage signal between the first electrode and the second electrode, determining (202) a current signal in response to the applied modulated voltage signal, determining (203) an electric potential working point of the analyte sensor based on the determined current signal, operating (204) the analyte sensor at the determined electric potential working point, and measuring (205) the analyte concentration based on the electrical signal generated by the first electrode.
G01N 27/413 - Concentration cells using liquid electrolytes
G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
G01N 27/49 - Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
The present invention relates to an analyte sensor comprising a substrate, at least one first electrode, at least one second electrode and at least one protective layer covering the at least one second electrode. The present invention further relates to a process for manufacturing the inventive analyte sensor as well as to an analyte sensor system comprising an analyte sensor according to the present invention and an electronics unit. The analyte sensor according to the present invention may mainly be used for conducting analyte measurements in a body fluid of a user.
An analyte sensor comprises a substrate, at least one working electrode, at least one second electrode and a membrane, wherein the membrane is located on top of the second electrode, and the second electrode has at least one first silver layer and at least one second silver layer which partially overlap with one another and have different compositions, i.e. silver percentages. The sensor includes at least one exposed area of the first silver layer disposed on the exterior of the sensor to provide for direct contact with body fluid when implanted. The disclosure further relates to a process for manufacturing an analyte sensor.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software; downloadable mobile applications;
computer software applications; computer software platforms. Medical instruments and apparatus. Data collection services in the field of health care and
medicine. Platform as a service [PaaS]; scientific research for
medical purposes. Medical services in the field of diabetes.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software; downloadable mobile applications;
computer software applications; computer software platforms. Medical instruments and apparatus. Data collection services in the field of health care and
medicine. Platform as a service [PaaS]; scientific research for
medical purposes. Medical services in the field of diabetes.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer software; downloadable mobile applications; computer software applications; computer software platforms in the field of diabetes.
(2) Medical instruments and apparatus in the field of diabetes. (1) Data collection services in the field of diabetes.
(2) Platform as a service [PaaS]; scientific research for medical purposes.
(3) Medical services in the field of diabetes.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer software; downloadable mobile applications; computer software applications; computer software platforms in the field of diabetes.
(2) Medical instruments and apparatus in the field of diabetes. (1) Data collection services in the field of diabetes.
(2) Platform as a service [PaaS]; scientific research for medical purposes.
(3) Medical services in the field of diabetes.
51.
NON-INVASIVE DETERMINATION OF BLOOD GLUCOSE LEVELS
A method to determine a subject's blood glucose level non-invasively by analyzing an exhaled breath or another gaseous emanation from the subject, comprising non-invasively detecting an amount of at least one volatile organic marker in the subject's exhaled breath or the subject's other gaseous emanation as marker data and determining the subject's blood glucose level based on the marker data, wherein the volatile organic marker is selected from a group of markers for which the amount of the volatile organic marker is negatively correlated to the blood glucose level. The volatile organic marker is one of indole (C8H7N), a partly saturated derivative of indole, a fully saturated derivative of indole and a true fraction of indole.
An analyte sensor (110) for determining at least one analyte and a method (140) for producing an analyte sensor (110) are disclosed. The analyte sensor (110) comprises: - a substrate (112); - a working electrode (118) and a conductive layer (122, 124) located on different sites on the substrate (112); - a silver comprising layer (126) partially covering the conductive layer (124); and - a protective layer (128) covering - the silver comprising layer (126) fully apart from at least one area (130) accessible to at least one body fluid comprising the at least one analyte; and - a portion of the conductive layer (124). The analyte sensor (110) as proposed herein significantly reduces noise during measurements. The method (140) which can be performed in an easier manner compared to producing prior art analyte sensors allows considerably higher tolerances during the producing of the analyte sensor (110).
A method for generating activity recommendations in a diabetes treatment plan includes receiving physiological data, preferences, and suggested activities for a person with diabetes (PwD), generating physiological profiles for the PwD, providing the physiological profiles to a virtual physiological model, receiving projections from a virtual physiological model, generating weighted values based on the suggested activities and preference data, each weighted value corresponding to a likelihood of the PwD adhering to a suggested activity, ranking each activity based on the estimated change in the physiological characteristic of a projection associated with the activity relative to a baseline physiological projection and scaled by the weighted value corresponding to each activity, and generating an output including a predetermined number of suggested activities ordered based on the ranking of activities that provide a greatest change in the physiological characteristic given the likelihood of the PwD adhering to the suggested activities.
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
54.
METHOD FOR DETERMINING A RELIABILITY OF AN ANALYTE SENSOR
A method for determining a reliability of an analyte sensor (110) is proposed. The analyte sensor (110) is an in vivo sensor. The method comprises the steps: a) measuring at least one first temperature dependent signal; b) measuring at least one second temperature dependent signal which is different from the first temperature dependent signal and which is related to a current flow in the analyte sensor (110); c) correlating the first temperature dependent signal and the second temperature dependent signal for determining the reliability of the analyte sensor (110).
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1495 - Calibrating or testing in vivo probes
The present invention relates to a medical device system comprising a body-wearable medical device, and a disposable container comprising a reservoir volume configured for storing a foodstuff or a drug and a tamper evident closure which seals an opening in the disposable container, wherein the opening provides access to the reservoir volume. To reduce the burden of the patient to compose the packages to be carried along by a patient when leaving home, the disposable container comprises a body-wearable medical device fastener configured for detachable fastening the disposable container to the body-wearable medical device and/or the body-wearable medical device comprises a disposable container fastener configured for detachable fastening the body-wearable medical device to the disposable container.
Method and means for postprandial blood glucose level prediction The invention relates to a method (100) for predicting blood glucose levels, in particular for postprandial blood glucose level prediction, the method being computer-implemented and comprising: receiving (101) a first medical data set of a patient covering a time range, said first medical data set comprising glucose data and further other medical data of said patient, extracting (102) a second medical data set from said first medical data set, wherein the second medical data set is a subset of the first medical data set and wherein the extracting comprises at least one of: identifying (103) duplicates in the first medical data set and removing identified duplicates, identifying (104) data values that lie above a predefined maximum threshold data value or identifying (105) data values that lie below a predefined minimum threshold data value and removing data associated to said identified data values, identifying (106) data values that differ from predetermined expected data values by more than a predetermined amount and removing data associated to said identified data values, identifying (107) incomplete data for which data values are missing and removing identified incomplete data, identifying (108) at least one predetermined time-dependent data pattern and removing data associated to said identified time-dependent data pattern, providing (109) the extracted second medical data set as input to a blood glucose level prediction model, and predicting (110) future blood glucose levels of the patient using the output of the blood glucose level prediction model based on the second medical data set.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
58.
METHOD FOR SCREENING A SUBJECT FOR THE RISK OF CHRONIC KIDNEY DISEASE, COMPUTER-IMPLEMENTED METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT
A method for screening a subject for the risk of chronic kidney disease (CKD) is provided, the method comprising: receiving marker data indicative for a plurality of marker parameters for a subject, such plurality of marker parameters indicating at least an age value, a time since diagnosis value indicative of a time since a diabetes diagnosis for the subject, a sample level of creatinine, an estimated glomerular filtration rate, a sample level of albumin, and a sample level of blood urea nitrogen; and determining a risk factor indicative of the risk of suffering CKD for the subject from the plurality of marker parameters. Further, a computer-implemented method for screening a subject for the risk of CKD is provided. Also, a system comprising a processor and a non-transitory memory storing a program causing the processor to perform the method for screening a subject for the risk of CKD is provided. In another aspect, a computer program product comprising instructions which, when the program is executed by a computer, cause the computer to carry out the method for screening a subject for the risk of CKD is provided.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
The invention relates to a method (100) for updating at least one medical practice software for displaying and analyzing blood glucose data on at least one computing device of a plurality of computing devices of a local network, the method comprising: determining (101), by a first computing device of said plurality of computing devices, what versions of the at least one medical software are installed on the computing devices of said plurality of computing devices; receiving (102), at a first computing device of said plurality of computing devices, at least one software patch, said software patch comprising at least one update for a version of the medical software installed on at least one computing device of said plurality of computing devices; identifying (103), by the first computing device, which of the at least one computing device of said plurality of computing devices has installed a version of the at least one software that requires an update comprised in said at least one software patch; transmitting (104), by the first computing device, a copy of the at least one software patch, to at least one computing device of said plurality of computing devices that has been identified as having installed a version of the at least one medical practice software that requires an update comprised in said at least one software patch; and installing (105) the at least one update from the software patch to update the medical practice software on at least one computing device identified by the first computing device.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
Goods & Services
downloadable computer software, downloadable mobile applications, downloadable computer software applications and downloadable computer software platforms, all for use with devices for monitoring blood glucose levels by individuals with diabetes, namely, for enabling users to link blood glucose monitors to the foregoing software, mobile applications and software platforms, for collecting, recording, storing, tracking, managing and analyzing user healthcare data, for analyzing and evaluating user healthcare data to provide users with predictions about potential diabetes medical conditions and outcomes, for enabling users to input and track data and progress related to their diabetes management activities, and for transmitting user healthcare data to healthcare providers medical instruments and apparatus for use in the field of diabetes, namely, blood glucose meters, devices for monitoring blood glucose levels, and medical test kits for diabetes monitoring electronic data collection services for business purposes in the field of diabetes healthcare providing online non-downloadable data collection software for collecting data from medical and consumer devices, for use by healthcare providers and individuals with diabetes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
Goods & Services
downloadable computer software, downloadable mobile applications, downloadable computer software applications and downloadable computer software platforms, all for use with devices for monitoring blood glucose levels by individuals with diabetes, namely, for enabling users to link blood glucose monitors to the foregoing software, mobile applications and software platforms, for collecting, recording, storing, tracking, managing and analyzing user healthcare data, for analyzing and evaluating user healthcare data to provide users with predictions about potential diabetes medical conditions and outcomes, for enabling users to input and track data and progress related to their diabetes management activities, and for transmitting user healthcare data to healthcare providers medical instruments and apparatus for use in the field of diabetes, namely, blood glucose meters, devices for monitoring blood glucose levels, and medical test kits for diabetes monitoring electronic data collection services for business purposes in the field of diabetes healthcare providing online non-downloadable data collection software for collecting data from medical and consumer devices, for use by healthcare providers and individuals with diabetes
63.
MEANS AND METHODS FOR IMPLANTING CELLS SECRETING A THERAPEUTIC COMPOUND
The present invention relates to a device for implantation into a mammalian host, said device comprising a) a dialysis tube with a lumen and a dialysis membrane enclosing said lumen, wherein i) the dialysis tube has an outer diameter of from 20 µm to 600 µm; and ii) the dialysis membrane has a molecular weight cutoff of from 25 kDa to 150 kDa and comprises at least one material selected from the group consisting of polyethersulfone, polyarylethersulfone, polyethylene, polytetrafluoroethylene, polyvinylidene fluoride, and polypropylene; and b) a therapeutic composition disposed within the lumen of the dialysis tube, wherein said therapeutic composition comprises a plurality of cells secreting a therapeutic compound and a matrix material embedding said cells secreting a therapeutic compound, wherein the matrix material is selected from alginate, collagen, fibrin, extracellular matrix material, synthetic hydrogel, and acrylate, in an embodiment the matrix material is alginate. The present invention further relates to a method of producing a device for implantation, a port system, and a cell secreting a therapeutic compound for use in treating disease by implantation of said cell in a device for implantation according to the present invention.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software; downloadable mobile applications; computer software applications; computer software platforms. Medical instruments and apparatus. Data collection services in the field of health care and medicine. Platform as a Service [PaaS]; scientific research for medical purposes. Medical services in the field of diabetes.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software; downloadable mobile applications; computer software applications; computer software platforms. Medical instruments and apparatus. Data collection services in the field of health care and medicine. Platform as a Service [PaaS]; scientific research for medical purposes. Medical services in the field of diabetes.
66.
INSERTION SYSTEM AND METHOD FOR INSERTING A MEDICAL DEVICE
An insertion system (110) is disclosed. The insertion system (110) comprises a medical device (112) and an insertion device (113) for inserting the medical device (112) into a body tissue of a user, the insertion device (113) comprising: i) an insertion component (118) configured for inserting the medical device (112) into the body tissue; ϋ) an insertion component retractor (120); iii) a cap (122); iv) a guide sleeve (124) and an insertion sleeve (128) guided therein; v) a locking sleeve (126) positioned in the insertion sleeve (128); and vi) an elastic member (130) positioned between the locking sleeve (126) and the insertion component retractor (120); wherein, for inserting the medical device (112), the cap (122), the insertion component retractor (120), the locking sleeve (126) and the insertion sleeve (128) are movable relative to the guide sleeve (124) from a distal position to a proximal position, wherein the insertion device (113) is separable from the medical device (112), wherein the insertion system (110) is configured such that a separation of the insertion device (113) from the medical device (112) releases a movement of the locking sleeve (126) from its proximal position to a further proximal position.
Medical device efficiency detection methods and systems including a photoplethysmography (PPG) sensor device, a processor, a memory, and machine readable instructions that may cause the system to receive a notification at the PPG device from the medical device upon delivery of the therapy treatment, use the PPG device to search for a signal response of the user based on the notification within a period of time to generate a response signal indicative of therapy treatment delivery, and transmit an alert when the response signal is not generated in the period of time indicative of a failure to detect sufficient therapy treatment delivery. The instructions may cause the system to transmit an alert when signal measurements from the PPG device of an infusion site are not within a sufficient signal range to indicate the infusion site is insufficient for delivery of the therapy treatment by the medical device.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A user device (e.g., a mobile device) receives testing period data during a testing period. The user device determines that a portion of the data is missing based on an analysis of the received testing period data. The analysis of the received data includes an analysis of one or more blood glucose levels and an analysis of the dietary intake data, the medication data, and the activity data. The user device imputes the missing portion of the data with substitute data determined using predictive learning. The user device calculates a confidence level associated with the substitute data. The user device identifies, using the substitute data, a progression or a regression in a diabetic condition associated with the user.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
69.
METHOD FOR PREPARING A COUNTER/REFERENCE ELECTRODE
The present invention generally relates to a method for the preparation of an electrode and to an analyte sensor comprising the electrode as well as to the use of the analyte sensor for detecting at least one analyte in a sample. In particular, the invention relates to a method for the preparation of an electrode, the method comprising a partial reduction of Ag+ cations present in the electrode material.
A method for the preparation of a working electrode comprises application of a sensing material in several steps. Further, an analyte sensor comprises the working electrode and is used for detecting at least one analyte in a sample.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
B05D 1/26 - Processes for applying liquids or other fluent materials performed by applying the liquid or other fluent material from an outlet device in contact with, or almost in contact with, the surface
B05D 5/02 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a matt or rough surface
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
The present invention relates to a method for the preparation of a working electrode, the method comprising application of a sensing material in several steps. Further, the present invention relates to an analyte sensor comprising the working electrode as well as to the use of the analyte sensor for detecting at least one analyte in a sample.
The present invention generally relates to a flux-limiting polymer membrane for an analyte sensor and to an analyte sensor comprising a flux-limiting polymer membrane.
A method (110) for producing an analyte sensor (112), an analyte sensor (112) obtainable by this method (110), and a use of the analyte sensor (112) are disclosed. The method (110) comprising the steps of: a) providing a first substrate (114) having o a first side (116), and o a second side (118), wherein the second side (118) has a first layer (120) comprising a first conductive material (122); b) providing a second substrate (124) having o a first side (126), wherein the first side (126) has a second layer (130) comprising a second conductive material (132), and o a second side (128), wherein second side (128) has a third layer (134) comprising a third conductive material (136); c) applying a layer (138) of an conductive preparation (140) onto at least one of the first side (116) of the first substrate (114) or the third layer (134) or a portion thereof, wherein the conductive preparation (140) comprises o a plurality of conductive particles, and o at least one polymeric binder; d) laminating the first side (116) of the first substrate (114) with the second side (128) of the second substrate (124); and e) obtaining the analyte sensor (112). The method (110) is a cost-efficient process which allows producing the analyte sensor (112) in a reliable and fast fashion, whereby an individual tailoring of the analyte sensor (112) is, concurrently, possible.
P36339 - 35 - Method for manufacturing at least one electrode of an analyte sensor Abstract A method for manufacturing at least one electrode (110) of an analyte sensor (112) is dis-5 closed. The method comprises the following steps: a) providing (116) a stencil (118), wherein the stencil (118) comprises a first stencil side (120), a second stencil side (122) and at least one through hole (124) reaching from the first stencil side (120) to the second stencil side (122), wherein at least one of the first stencil side (120) and the second stencil side (122) has first wetta-10 bility properties; b) providing (126) a substrate (128), wherein the substrate (128) comprises a first side (130) and a second side (134); c) applying (136) the stencil (118) to the first side (130) of the substrate (128); d) applying (138) a low viscosity composition (140) into the through hole (124) of 15 the stencil (118), wherein the low viscosity composition (140) has second wetta- bility properties opposing to the first wettability properties of the at least one of the first stencil side (120) and the second stencil side (122); e) drying (141) the low viscosity composition (140); f) obtaining (142) the at least one electrode (110). 20 (Figure 2A)
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
75.
ANALYTE SENSOR SYSTEM AND A METHOD FOR ITS PRODUCING
An analyte sensor system (110) and a method (160) for producing an analyte sensor system (110) are disclosed. Herein, the analyte sensor system (110) comprises: - an analyte sensor having o a first contact pad, and o a second contact pad; - a circuit carrier having o a first contact area, and o a second contact area, wherein the second contact area comprises at least two individual electrically conductive surfaces; and - a connecting element electrically connecting the second contact pad of the analyte sensor with each of the at least two individual electrically conductive surfaces of the second contact area of the circuit carrier. The analyte sensor system (110) as proposed herein allows a reliable and persistent electrical contact between the analyte sensor (112) and the circuit carrier (114) which minimizes a risk of short circuits.
A method of controlling auto-exposure settings of a mobile device having at least one camera is disclosed. The method comprises a) providing a color reference card (110) and an optical test strip (118) having a test field (120) having a sample applied thereto, o wherein the color reference card (110) comprises a plurality of different color reference fields (112) having known reference color values and one or more gray background fields (114) having defined gray values, b) setting an exposure metering area and determining auto-exposure settings based on the scene (126) in the set exposure metering area; o wherein the scene (126) in the set exposure metering area comprises at least part of the reagent test field (120) of the optical test strip (118) having the sample applied thereto, and at least part of the plurality of different color reference fields (112) and at least part of the one or more gray background fields (114) of the color reference card (110), c) capturing, by using the camera (120), at least one image comprising the scene (126) of step b) o wherein the determined auto-exposure settings of step b) are used. A method of determining the concentration of an analyte in a sample by using a mobile device is also disclosed.
A method of determining the concentration of at least one analyte in a bodily fluid by using a mobile device (112) is disclosed, the mobile device (112) having at least one camera (114) and at least one ambient light detector (122), the ambient light detector (122) comprising at least one of an ambient light sensor (124) and an additional camera (126), the method comprising: i. performing at least one ambient light check (178), the ambient light check (178) comprising: i.1 using the ambient light detector (122) for determining at least one item of ambient light information; and i.2 determining if at least one validity criterion on the item of ambient light information is fulfilled; ii. if the validity criterion is fulfilled, determining the concentration of the analyte in the bodily fluid by evaluating at least one image of at least a part of at least one reagent test region (118) of an optical test strip (116) having a sample of the bodily fluid applied thereto, the image being captured by the camera (114) of the mobile device (112). Further, a mobile device (112), a kit (110), a computer program and a computer-readable storage medium is disclosed.
A test strip eject mechanism for a fluid testing device comprising an actuation button and a lever having a distal end movably engaged with the button, the lever configured to rotate about a fulcrum, wherein the lever has a proximal end movably engaged with a sled which slides to transport the test strip, the device configured such that a user's insertion of a test strip onto the sled and in an insertion direction into the device causes the sled to contact the lever arm and the lever arm to contact and move the actuation button in an outward direction of the medical device and into a position where the actuation button can be actuated by the user.
The invention relates to a method of manufacturing an in vivo analyte sensing device, which is adapted for detecting at least one analyte in a body fluid or tissue and an in vivo analyte sensing device obtainable by said manufacturing method. Further, the present invention relates to a method of manufacturing a sensor base plate and a sensor base plate obtainable by said manufacturing method. The sensor base plate may be used for the manufacture of an in vivo analyte sensing device.
An insertion device (110) for inserting a medical device (112) into a body tissue of a user is disclosed. The insertion device (110) comprises: i) the medical device (112); ii) an insertion component (118) configured for inserting the medical device (112) into the body tissue; iii) an insertion component retractor (120); iv) a cap (122); v) a guide sleeve (124) comprising at least one ramp (126); and vi) an insertion sleeve (128); and vii) an elastic member (130); wherein, for inserting the medical device (112), the cap (122), the insertion component retractor (120) and the insertion sleeve (128) are movable relative to the guide sleeve (124) from a distal position (164) to a proximal position (166), wherein the ramp (126) of the guide sleeve (124) is configured to twist the insertion component retractor (120) relative to the guide sleeve (124) and the insertion sleeve (128) when the cap (122) is moved from its distal position (164) to its proximal position (166), wherein the cap (122) is movable from its proximal position (166) to its distal position (164), thereby the insertion component retractor (120) is moved from its proximal position (166) to its distal position (164). Further, a method for inserting a medical device (112) into a body tissue of a user is disclosed.
A method for detecting a failure of at least one component (122) of a continuous analyte monitoring system (110) is proposed. The continuous analyte monitoring system (110) comprises the component (122) and at least one failure detection resistor (124). The continuous analyte monitoring system (110) comprises at least one analyte sensor (112) comprising at least two measurement electrodes (114). The method comprises the following steps: i) applying a constant voltage between the at least two measurement electrodes (112) of the analyte sensor (114) and measuring a first response signal, ii) applying a failure detection signal distinguishable from the constant voltage and/or from the first response signal in frequency and/or in height to the continuous analyte monitoring system and measuring a second response signal to the failure detection signal using the failure detection resistor (124); iii) determining an information depending on at least one actual property of the component by evaluating the first response signal and the second response signal, wherein a failure is detected if the information deviates from at least one expected value more than at least one predetermined tolerance.
A61B 5/1495 - Calibrating or testing in vivo probes
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer software and software applications for accessing medical and health information; computer software and software applications for use in the diagnosis, monitoring and treatment of medical and health information; downloadable computer software to facilitate support and sharing of health information for patients living with diabetes and diabetes-related conditions; downloadable computer software, namely, software for diabetes management and glucose tracking; downloadable mobile application to facilitate monitoring of health and wellness data to patients living with diabetes and diabetes-related conditions; downloadable mobile application to facilitate support and sharing of health information for patients living with diabetes and diabetes-related conditions;
(2) Printed course materials in the fields of general health and well-being; printed educational materials in the field of personal care; printed manuals; training manuals; (1) Education services, namely conducting classes, workshops, training seminars, and discussion forums in the fields of medical devices; providing professional coaching services in the field of health management for patients living with diabetes and diabetes-related condition;
(2) Medical services in the field of diabetes; providing information relating to health and wellness, namely, diabetes; providing information via the Internet in the field of diabetes; public health counselling;
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) computer software and software applications for accessing medical and health information; computer software and software applications for use in the diagnosis, monitoring and treatment of medical and health information; downloadable computer software to facilitate support and sharing of health information for patients living with diabetes and diabetes-related conditions; downloadable computer software, namely, software for diabetes management and glucose tracking; downloadable mobile application to facilitate monitoring of health and wellness data to patients living with diabetes and diabetes-related conditions; downloadable mobile application to facilitate support and sharing of health information for patients living with diabetes and diabetes-related conditions;
(2) Printed course materials in the fields of general health and well-being; printed educational materials in the field of personal care; printed manuals; training manuals; (1) Education services, namely conducting classes, workshops, training seminars, and discussion forums in the fields of medical devices; providing professional coaching services in the field of health management for patients living with diabetes and diabetes-related condition;
(2) Medical services in the field of diabetes; providing information relating to health and wellness, namely, diabetes; providing information via the Internet in the field of diabetes; public health counselling;
84.
APPARATUS FOR INSERTING A MEDICAL DEIVCE INTO A BODY TISSUE
An apparatus (110), specifically a medical system (112), is disclosed, the apparatus (110) comprising: a. a medical device (114) which is at least partially insertable into a body tissue of a user; b. an insertion device (116) for at least partially inserting the medical device (114) into the body tissue; c. a housing (118); and d. a removable cap (120) connected to the housing (118), the removable cap (120) being configured for being removed from the housing (118) before insertion of the medical device (114), wherein the housing (118) and the removable cap (120), prior to removal of the removable cap (120), are connected via at least one flexible connection element (122), wherein the flexible connection element (122) is reversibly displaceable from a locking position (216) in which the removable cap (120) is secured to the housing (118) by the flexible connection element (122) into a releasing position (218) in which the removable cap (120) is released, wherein the flexible connection element (122), prior to use, is secured in the lock- ing position (216) by at least one frangible securing element (124). Further, a method for preparing the apparatus (110) for insertion of at least a part of the medical device (114) into the body tissue of the user and a method for at least partially inserting at least a part of the medical device (114) of the apparatus (110) into the body tissue of the user are disclosed.
A method for operating a medical device includes activating a processor that receives electrical power from a battery in the medical device, measuring a temperature within a housing of the medical device, identifying a low battery voltage threshold based on the temperature, measuring a first voltage level of the battery, commencing an operation sequence after measuring the first voltage level of the battery, generating a plurality of voltage comparisons between a reference voltage level and a voltage level delivered from the battery during the operation sequence, and generating, an output indicating a low battery condition if at least one of the first voltage level of the battery is less than the low battery voltage threshold and above a predetermined minimum operating voltage threshold, or at least one voltage comparison indicating the voltage level of the battery is less than the reference voltage level during the operation sequence.
G01R 31/3835 - Arrangements for monitoring battery or accumulator variables, e.g. SoC involving only voltage measurements
G01R 31/374 - Arrangements for testing, measuring or monitoring the electrical condition of accumulators or electric batteries, e.g. capacity or state of charge [SoC] with means for correcting the measurement for temperature or ageing
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
86.
TEST STRIP FIXATION DEVICE FOR OPTICAL MEASUREMENTS OF AN ANALYTE
The present invention relates to a test strip fixation device - being configured to be used in a method for determining a concentration of an analyte in a bodily fluid by using a mobile device having a camera, said method comprising capturing by the camera at least one image containing at least a part of an optical test strip and at least a part of said test strip fixation device, the optical test strip having a sample of the bodily fluid applied onto a reagent test region of the optical test strip, wherein the image comprises at least a part of the reagent test region having the sample of the bodily fluid applied thereto, and wherein the image comprises at least a part of a top surface of the test strip fixation device; said test strip fixation device comprising a) an essentially planar shape; b) a cut-out portion; c) a top surface comprising a plurality of color reference fields having known reference color values, including grey reference fields locally arranged around the cut-out portion and around at least some of the non-grey color reference fields; and comprising position detection code elements; d) a bottom surface comprising a fixation element for detachable connection of the optical test strip relative to said test strip fixation device, such that the reagent test region can be aligned with the cut-out portion.
The present invention relates to a computer-implemented method, a mobile device, and a computer readable storage medium, for displaying a medical value such as, e.g., a glucose value, on a screen of a mobile device.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
88.
METHOD FOR DETERMINING AN ANALYTE CONCENTRATION IN A FLUID
A method for determining an analyte concentration in a fluid using an analyte sensor (110) is disclosed. The analyte sensor (110) comprises at least two measurement electrodes (112), wherein at least one of the measurement electrodes (112) comprises an analyte-responsive polymer gel (114), the method comprising the following steps: a) contacting at least the analyte-responsive polymer gel (114) of the analyte sensor (110) with the fluid comprising the analyte; b) generating at least one fast-transient voltage signal and applying the fast-transient voltage signal to the measurement electrodes (112); c) measuring at least one response signal; d) determining the analyte concentration by evaluating the response signal.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
G01N 33/66 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
The present invention relates to an analyte sensor comprising a substrate, at least one working electrode, at least one second electrode and a membrane, wherein the membrane is located on top of the at least one second electrode. The present invention further relates to a process for manufacturing the inventive analyte sensor as well as to an analyte sensor system comprising an analyte sensor according to the present invention and an electronics unit. The analyte sensors according to the present invention may mainly be used for conducting an analyte measurement in a body fluid of a user.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 27/30 - Electrodes, e.g. test electrodes; Half-cells
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
90.
METHOD OF PERFORMING AT LEAST ONE ANALYTICAL MEASUREMENT BY USING A MOBILE DEVICE
A method of performing at least one analytical measurement is disclosed. The method comprises using using a mobile device (112) having at least one camera (116). The method further comprises: i) capturing, by using the camera (116), a time series of images of at least a part of at least one medical article (114); ii) deriving, from the time series of images, image-derived position information on a relative position of the mobile device (112) and the medical article (114), thereby generating a first time series of position information; iii) capturing, by using at least one sensor device (118) of the mobile device (112), measurement information on the relative position of the mobile device (112) and the medical article (114); iv) deriving, from the measurement information, measurement-derived position information on the relative position of the mobile device (112) and the medical article (114), thereby generating a second time series of position information; v) generating an augmented time series of position information by combining the first time series of position information and the second time series of position information; and vi) providing guidance to a user, based on the augmented time series of position information, for changing the relative position of the mobile device (112) and the medical article (114) in order to have the user bring the mobile device (112) into at least one relative target position of the mobile device (112) and the medical article (114). Further, a mobile device (112), a kit (110) for performing at least one analytical measurement, a computer program and a computer-readable storage medium is disclosed.
An analyte sensor (130) for determining an analyte concentration in a body fluid (132) and a method for producing the analyte sensor (130) are disclosed. The analyte sensor (130) comprises: − a substrate (134) having a first surface (136), the first surface (136) being configured to be faced towards the body fluid (132) comprising the analyte; − a working electrode (140); − an interferent electrode (142); and − at least one further electrode (144) selected from the group consisting of a counter electrode (146), a reference electrode and a counter/ reference electrode; wherein each of the working electrode (140) and the interferent electrode (142) comprises a layer (210) of a conductive material (212), wherein the working electrode (140) further comprises at least one enzyme, whereas the interferent electrode (142) is devoid of enzyme, and wherein the interferent electrode (142) and the working electrode (140) are electrically separated layers located adjacently on the first surface (136) of the substrate (134). The analyte sensor (130) allows a precise determination of the analyte concentration although interferents may be comprised by the body fluid (132).
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
A method for secure interoperability between an electronic device and a medical device has been developed. The method includes executing a control application configured to provide communication between the electronic device and medical device, receiving user authentication data from an authentication service, receiving a key identifier from the medical device via an untrusted connection, and transmitting a message with an identifier of the user, the user authentication data, the key identifier, an identifier of the control application, and a cryptographic signature to an authorization service. The method further includes receiving a medical device cryptographic key from the authorization service only in response to successful verification of the message to enable at least one of control communication and data communication between the control application and the medical device.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04L 29/06 - Communication control; Communication processing characterised by a protocol
93.
METHOD OF DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE OF A BODILY FLUID, MOBILE DEVICE, KIT, COMUTER PROGRAM AND COMPUTER-READABLE STORAGE MEDIUM
A method of determining the concentration of at least one analyte in a sample of a bodily fluid by using a mobile device (112) having at least one camera (120), the method comprising: i) capturing, by using the camera (120), at least one image of at least a part of a color reference card (118) and of at least a part of at least one reagent test field (116) of at least one optical test strip (114) having the sample applied thereto, - wherein, in the image, the test field (116) is in a defined position with respect to the color reference card (118), - wherein the color reference card (118) comprises a plurality of different gray reference fields (126) locally assigned to the test field (116), wherein the plurality of gray reference fields (126) and the test field (116) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the test field (116) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the test field (116), and - wherein the color reference card (118) comprises a plurality of different color reference fields (128) having known reference color values and a plurality of different gray reference fields (126) locally assigned to the color reference fields (128), wherein the plurality of gray reference fields (126) and the color reference fields (128) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the color reference fields (128) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the color reference fields (128), ii) applying at least one predetermined pixel-based mean tone map correction to the image obtained in step i), thereby obtaining at least one first intensity-corrected image, wherein the predetermined pixel-based mean tone map correction comprises an assignment of a second brightness value to a first brightness value, wherein the first brightness value is recorded by the camera (120), wherein each pixel of the recorded image is corrected individually by the predetermined A method of determining the concentration of at least one analyte in a sample of a bodily fluid by using a mobile device (112) having at least one camera (120), the method comprising: i) capturing, by using the camera (120), at least one image of at least a part of a color reference card (118) and of at least a part of at least one reagent test field (116) of at least one optical test strip (114) having the sample applied thereto, - wherein, in the image, the test field (116) is in a defined position with respect to the color reference card (118), - wherein the color reference card (118) comprises a plurality of different gray reference fields (126) locally assigned to the test field (116), wherein the plurality of gray reference fields (126) and the test field (116) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the test field (116) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the test field (116), and - wherein the color reference card (118) comprises a plurality of different color reference fields (128) having known reference color values and a plurality of different gray reference fields (126) locally assigned to the color reference fields (128), wherein the plurality of gray reference fields (126) and the color reference fields (128) are locally assigned to each other by being placed in neighboring positions or wherein the plurality of gray reference fields (126) locally assigned to the color reference fields (128) are arranged on the color reference card (118) such that the plurality of gray reference fields (126) surrounds the color reference fields (128), ii) applying at least one predetermined pixel-based mean tone map correction to the image obtained in step i), thereby obtaining at least one first intensity-corrected image, wherein the predetermined pixel-based mean tone map correction comprises an assignment of a second brightness value to a first brightness value, wherein the first brightness value is recorded by the camera (120), wherein each pixel of the recorded image is corrected individually by the predetermined pixel- based mean tone map correction, wherein the mean tone map correction is derived by combining a plurality of tone map corrections for different types of mobile devices; iii) deriving, from the first intensity-corrected image, local brightness information (174) for at least some of the color reference fields (128) and for the test field (116), by using the gray reference fields (126) locally assigned to the color reference fields (128) and the test field (116), respectively, wherein the local brightness information (174) comprises a numerical indication describing the local intensity of at least one RGB color of the color reference fields (128) and the test field (116), respectively; iv) applying at least one mobile device-specific tone map correction to the first intensity-corrected image, the mobile device-specific tone map correction taking into account the local brightness information (174), thereby obtaining at least one second intensity-corrected image; and v) determining the analyte concentration based on a color formation reaction of the test field (116) by using the second intensity-corrected image.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01N 21/29 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
G01N 21/84 - Systems specially adapted for particular applications
G06T 7/90 - Determination of colour characteristics
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
94.
METHOD AND SYSTEM FOR GENERATING A SOFTWARE-IMPLEMENTED MODULE FOR DETERMINING AN ANALYTE VALUE, COMPUTER PROGRAM PRODUCT, AND METHOD AND SYSTEM FOR DETERMINING AN ANALYTE VALUE
A method is disclosed for generating a software-implemented module for determining an analyte value, comprising, in an arrangement of one or more data processors: providing a first set of input data indicative of first values measured for a plurality of input parameters, the input parameters comprising a first and a second input parameter; and providing a second set of input data indicative of second values for the plurality of input parameters, the second values comprising an augmented value for at least one input parameter from the plurality of input parameters, the augmented value being different from the first value measured for the at least one input parameter and determined by augmenting the first value; and the first value for at least one remaining input parameter from the plurality of input parameters. The method further comprises: determining first analyte data indicative of a first plurality of analyte values for an analyte by processing the first set of input data by a physiological model; determining second analyte data indicative of a second plurality of analyte values for the analyte by processing the second set of input data by the physiological model; determining a set of training data from both the first analyte data and the second analyte data; determining a set of test data, the set test data being different from the set training data; providing a software-implemented machine learning model configured to determine an analyte value for the analyte; training the software-implemented machine learning model by the set of training data; and testing the software-implemented machine learning model by the set of test data. Furthermore, a system for generating a software-implemented module for determining an analyte value, a computer program product for generating a software-implemented module for determining an analyte value, a method for determining an analyte value, and a system for determining an analyte value are provided.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
95.
METHOD OF EVALUATING THE QUALITY OF A COLOR REFERENCE CARD
A method of evaluating the quality of a color reference card (110), the color reference card (110) comprising a plurality of color reference fields (112) having known reference color values, the method comprising the following steps: i. capturing at least one image of at least a part of the color reference card (110) by using at least one camera (130) of at least one mobile device (128); ii. determining measured reference color values for at least some of the color reference fields (112) from the image; iii. determining a relationship between at least some of the measured reference color values and the corresponding known reference color values; and iv. deriving at least one item of quality information on the quality of the color reference card (110) by using the relationship of step iii. Further, a method for determining the concentration of an analyte in a bodily fluid, a mobile device (128), a kit (126), a computer program and a computer-readable storage medium are disclosed.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 21/84 - Systems specially adapted for particular applications
The present invention relates to a method for generating a software-implemented module configured to determine a drug dose, to a method for training a machine learning model to generate a software- implemented module and to a method for determining a drug dose. The present invention furthermore refers to a system for generating a software-implemented module, to a system for training a machine learning model, and to a system for determining a drug dose. Additionally, the present invention relates to a computer program product.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
97.
METHOD AND SYSTEM FOR STORING MEASUREMENT DATA DETECTED BY A SENSOR DEVICE AND INDICATIVE OF AN ANALYTE IN A SAMPLE OF A BODILY FLUID
A method and system for storing measurement data detected by a sensor device and indicative of an analyte in a sample of a bodily fluid is disclosed. The method comprises providing first measurement data indicative of a first measurement value for an analyte in a sample of a bodily fluid measured by a sensor device (13); providing second measurement data indicative of a second measurement value for the analyte in the sample of the bodily fluid measured by the sensor device (13); determining a relative measurement value by the processor, the relative measurement value being indicative of a value difference between the first measurement value and the second measurement value. The method further comprises providing first measurement storage data in a memory (12), comprising storing the first measurement value being assigned to a first storage area having a first storage size in the memory (12); providing relative measurement storage data in the memory (12), comprising storing the relative measurement value in the memory (12), the relative measurement storage data being assigned to a second storage area having a second storage size in the memory (12) which is smaller than the first storage size; and storing an indicator in the memory (12), the indicator being assigned to the relative measurement storage data in the memory (12) and indicative of a characteristic of the relative measurement storage data.
G06F 12/04 - Addressing variable-length words or parts of words
H03M 7/32 - Conversion to or from delta modulation, i.e. one-bit differential modulation
H03M 7/36 - Conversion to or from differential modulation with several bits, i.e. the difference between successive samples being coded by more than one bit
H03M 7/30 - Compression; Expansion; Suppression of unnecessary data, e.g. redundancy reduction
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
98.
METHOD AND SYSTEM FOR DETERMINING AT LEAST ONE MEMBRANE PROPERTY OF AN ANALYTE SENSOR
A method for determining at least one membrane property of an analyte sensor (112) is disclosed. The analyte sensor (112) comprises at least two measurement electrodes (114). At least one of the measurement electrodes (114) comprises at least one membrane element (122) having the at least one membrane property. The method comprising the following steps: a) generating at least one fast-transient voltage signal and applying the fast-transient voltage signal to the measurement electrodes (114); b) measuring at least one response signal; c) determining the at least one membrane property by evaluating of the response signal.
A method for the preparation of a working electrode (122) on a sensor substrate (114) is disclosed. The method comprising: • a) providing at least one sensor substrate (114) comprising at least a first side (120), the first side (120) comprising at least one conductive trace (111); • b) applying at least one layer of at least one sensing material (118) onto the first side (120) of the sensor substrate (114), wherein the sensing material (118) covers at least a portion of the at least one conductive trace (111); and • c) irradiating the layer of the sensing material (118) with at least one laser beam, wherein at least a first portion of the layer of the sensing material (118) is at least partially removed and wherein at least a second portion of the sensing material (118) covering the at least one conductive trace (111) is preserved on the first side (120) of the sensor substrate (114) to obtain at least one working electrode (122) on the sensor substrate (114), • e) applying at least one membrane layer, the membrane layer at least partially covering the working electrode, wherein the membrane layer comprises at least one cross-linker for cross- linking at least a part of the sensing material, wherein the method further comprises: • f) at least one diffusion step, wherein in the diffusion step the cross-linker comprised in the membrane layer at least partially diffuses into the sensing material.
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using enzyme electrodes, e.g. with immobilised oxidase
100.
MEDICAL SYSTEM AND METHOD OF STERILITY TESTING THE MEDICAL SYSTEM
The invention discloses a medical system (144). The medical system (144) comprises: i) a housing (146); ii) a preassembled functional module (110) received in the housing (146), the preassembled functional module (110) comprising a. an analyte sensor (112) for detecting at least one analyte in a body fluid of a user; b. an electronics unit (120) electrically connected to the analyte sensor (112); and c. an insertion component (114) for inserting the analyte sensor (112) into a body tissue of the user; and iii) at least one removable protective cap (148) connected to the housing (146), covering the preassembled functional module (110), wherein the preassembled functional module (110) further comprises at least one sterility cap (116), which at least partially surrounds the insertion component (114), wherein the at least one sterility cap (116) is at least partially surrounded by the protective cap (148), wherein the sterility cap (116) comprises at least one sterility testing access (140), the sterility testing access (140) comprising at least one of a septum (142) and a multiple-step sealing (162). Further, methods of providing the medical system (144) and of sterility testing of the medical system (144) are disclosed.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
