A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
F16K 11/072 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members
2.
METHODS OF INHIBITING OR TREATING CORONAVIRUS INFECTION, AND METHODS FOR DELIVERING AN ANTI-NUCLEOLIN AGENT
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (USA)
QUALIGEN INC. (USA)
Inventor
Abdul-Ahad, Wajdi
Poirier, Michael
Abstract
A method of administering an anti-nucleolin agent to a patient by delivering the anti-nucleolin agent to the mouth, lungs, throat, nose and eyes of a patient to prevent COVID-19. Compositions for administering an anti-nucleolin agent comprising a container and a formulation including an anti-nucleolin agent. The anti-nucleolin agent may be administered via an inhaler, nasal spray or eye drop.
A whole blood treatment device includes a cartridge configured to receive whole blood, having a wall defining an interior volume, an inlet, and an outlet, a support structure having a surface, inside of the cartridge, and an affinity agent, attached to the surface of the support structure. The affinity agent is effective to bind to a target agent that is desirable for removal from a patient. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals. A method of removing a target agent from whole blood of a patient in a whole blood treatment device comprising pumping whole blood into a cartridge, containing a support structure having a surface, with a plurality of affinity agents on the support structure, to contact the whole blood with the affinity agents; binding the target agent with the affinity agents; and removing the whole blood having a reduced amount of the target agent from the cartridge. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals.
The inventive subject matter is directed to point-of-care analytical devices that accurately determine the volume of test samples using image analysis to improve the accuracy of test results performed on the sample. Most preferably, the image analysis is based on rate changes in optical saturation that parallels sample saturation in a porous structure containing the sample.
Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
6.
IMPROVED SAMPLE INJECTION PORT FOR LAMINATED DEVICES
Contemplated diagnostic test containers and methods include an adapter configured to sealingly receive and retain a positive displacement pipette tip to so form a fluid-tight seal for the container during at least part of the diagnostic test. Most preferably, the entire container is flexible and the container and adapter are single-use disposable and are usable with known commercially available positive displacement pipette tips.
A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.
Devices and methods are contemplated in which pouch-based diagnostic and medical products are formed in a process that allows formation of distinct seals using application of distinct process control variables for the respective seals. Therefore, products having stronger permanent seals and at the same tome frangible seals with controlled breaking characteristics can be prepared in s simple and reproducible manner.
A container is formed from flexible top and bottom sheets and further includes an energy-deformable conduit. Contemplated containers include a plurality of compartments and a sample receiving compartment, wherein the conduit allows feeding a fluid into the sample compartment without feeding the fluid in the remaining compartments, which is preferably achieved by a flow-restriction portion in the conduit and a flow-control element between the sample receiving compartment and one or more of the compartments.
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