Qualigen, Inc.

United States of America

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2023 1
2022 3
2021 12
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2019 2
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IPC Class
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor 11
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers 8
B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms 6
C12M 1/38 - Temperature-responsive control 6
G01N 1/28 - Preparing specimens for investigation 5
See more
NICE Class
05 - Pharmaceutical, veterinary and sanitary products 10
10 - Medical apparatus and instruments 8
Status
Pending 6
Registered / In Force 45

1.

Whole blood treatment cartridge

      
Application Number 29833681
Grant Number D0979073
Status In Force
Filing Date 2022-04-06
First Publication Date 2023-02-21
Grant Date 2023-02-21
Owner Qualigen Inc. (USA)
Inventor Poirier, Michael

2.

QUALIGEN DIAGNOSTICS

      
Serial Number 97697382
Status Pending
Filing Date 2022-11-30
Owner Qualigen, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical devices for use in treating or diagnosing viral infections; Medical devices for use in treating or diagnosing cancer

3.

Whole blood treatment cartridge

      
Application Number 29738845
Grant Number D0952157
Status In Force
Filing Date 2020-06-19
First Publication Date 2022-05-17
Grant Date 2022-05-17
Owner Qualigen Inc. (USA)
Inventor Poirier, Michael

4.

WHOLE BLOOD TREATMENT DEVICE AND METHODS OF REMOVING TARGET AGENTS FROM WHOLE BLOOD

      
Application Number 17434107
Status Pending
Filing Date 2020-02-26
First Publication Date 2022-05-12
Owner Qualigen Inc. (USA)
Inventor Poirier, Michael

Abstract

A whole blood treatment device includes a cartridge configured to receive whole blood, having a wall defining an interior volume, an inlet, and an outlet, a support structure having a surface, inside of the cartridge, and an affinity agent, attached to the surface of the support structure. The affinity agent is effective to bind to a target agent that is desirable for removal from a patient. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals. A method of removing a target agent from whole blood of a patient in a whole blood treatment device comprising pumping whole blood into a cartridge, containing a support structure having a surface, with a plurality of affinity agents on the support structure, to contact the whole blood with the affinity agents; binding the target agent with the affinity agents; and removing the whole blood having a reduced amount of the target agent from the cartridge. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals.

IPC Classes  ?

  • A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
  • A61P 39/06 - Free radical scavengers or antioxidants

5.

DEVICES AND METHODS FOR ON-LINE WHOLE BLOOD TREATMENT

      
Application Number US2020039056
Publication Number 2021/262147
Status In Force
Filing Date 2020-06-23
Publication Date 2021-12-30
Owner QUALIGEN INC. (USA)
Inventor Poirier, Michael

Abstract

A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.

IPC Classes  ?

  • B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
  • A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • F16K 21/00 - Fluid-delivery valves
  • B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
  • F16K 11/072 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members

6.

Miscellaneous Design

      
Application Number 1621121
Status Registered
Filing Date 2021-09-02
Registration Date 2021-09-02
Owner Qualigen, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments

Goods & Services

Pharmaceutical preparations for the treatment and prevention of viral infections; pharmaceutical preparations for the treatment and prevention of cancer. Medical devices for use in treating or diagnosing viral infections; medical devices for use in treating or diagnosing cancer.

7.

METHODS OF INHIBITING OR TREATING CORONAVIRUS INFECTION, AND METHODS FOR DELIVERING AN ANTI-NUCLEOLIN AGENT

      
Application Number US2021024734
Publication Number 2021/202425
Status In Force
Filing Date 2021-03-29
Publication Date 2021-10-07
Owner
  • UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (USA)
  • QUALIGEN INC. (USA)
Inventor
  • Abdul-Ahad, Wajdi
  • Poirier, Michael

Abstract

A method of administering an anti-nucleolin agent to a patient by delivering the anti-nucleolin agent to the mouth, lungs, throat, nose and eyes of a patient to prevent COVID-19. Compositions for administering an anti-nucleolin agent comprising a container and a formulation including an anti-nucleolin agent. The anti-nucleolin agent may be administered via an inhaler, nasal spray or eye drop.

IPC Classes  ?

  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • A61P 11/00 - Drugs for disorders of the respiratory system
  • A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P 31/14 - Antivirals for RNA viruses

8.

circle with a series of dots

      
Application Number 214173100
Status Pending
Filing Date 2021-09-02
Owner Qualigen, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments

Goods & Services

(1) Pharmaceutical preparations for the treatment and prevention of viral infections; pharmaceutical preparations for the treatment and prevention of cancer. (2) Medical devices for use in treating or diagnosing viral infections; medical devices for use in treating or diagnosing cancer.

9.

Qualigen Therapeutics

      
Application Number 1583749
Status Registered
Filing Date 2021-02-24
Registration Date 2021-02-24
Owner Qualigen, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments

Goods & Services

Pharmaceutical preparations for the treatment and prevention of viral infections; pharmaceutical preparations for the treatment and prevention of cancer. Medical devices for use in treating or diagnosing cancer; medical devices for use in treating or diagnosing viral infections.

10.

Miscellaneous Design

      
Serial Number 90977664
Status Registered
Filing Date 2021-03-08
Registration Date 2022-10-11
Owner Qualigen, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for the treatment and prevention of viral infections; Pharmaceutical preparations for the treatment and prevention of cancer

11.

QUALIGEN

      
Serial Number 90566015
Status Pending
Filing Date 2021-03-08
Owner Qualigen, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical devices for use in treating or diagnosing viral infections; Medical devices for use in treating or diagnosing cancer

12.

Miscellaneous Design

      
Serial Number 90566095
Status Pending
Filing Date 2021-03-08
Owner Qualigen, Inc. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical devices for use in treating or diagnosing viral infections; Medical devices for use in treating or diagnosing cancer

13.

QUALIGEN THERAPEUTICS

      
Serial Number 90977658
Status Registered
Filing Date 2021-03-08
Registration Date 2022-09-20
Owner Qualigen, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for the treatment and prevention of viral infections; Pharmaceutical preparations for the treatment and prevention of cancer

14.

QUALIGEN

      
Serial Number 90977665
Status Registered
Filing Date 2021-03-08
Registration Date 2022-09-20
Owner Qualigen, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for the treatment and prevention of viral infections; Pharmaceutical preparations for the treatment and prevention of cancer

15.

Qualigen Therapeutics

      
Application Number 209662100
Status Registered
Filing Date 2021-02-24
Registration Date 2023-12-01
Owner Qualigen, Inc. (USA)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments

Goods & Services

(1) Pharmaceutical preparations for the treatment and prevention of cancer.

16.

DRIVEN TO DELIVER

      
Serial Number 90463957
Status Registered
Filing Date 2021-01-13
Registration Date 2022-07-05
Owner Qualigen, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Automated diagnostic kits comprised of diagnostic reagents and assays for testing body fluids for pharmaceutical use for treatment and diagnosis in cancer, cancer detection and infectious diseases

17.

DEVICES AND METHODS FOR ON-LINE WHOLE BLOOD TREATMENT

      
Application Number 16918494
Status Pending
Filing Date 2020-07-01
First Publication Date 2020-12-24
Owner Qualigen Inc. (USA)
Inventor Poirier, Michael

Abstract

A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.

IPC Classes  ?

  • A61M 5/165 - Filtering accessories, e.g. blood filters, filters for infusion liquids
  • B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
  • B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
  • B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
  • A61M 27/00 - Drainage appliances for wounds, or the like

18.

QUALIGEN THERAPEUTICS

      
Serial Number 90977666
Status Registered
Filing Date 2020-09-18
Registration Date 2022-10-04
Owner Qualigen, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Pharmaceutical preparations for the treatment and prevention of viral infections; pharmaceutical preparations for the treatment and prevention of cancer

19.

WHOLE BLOOD TREATMENT DEVICE AND METHODS OF REMOVING TARGET AGENTS FROM WHOLE BLOOD

      
Application Number US2020019993
Publication Number 2020/176683
Status In Force
Filing Date 2020-02-26
Publication Date 2020-09-03
Owner QUALIGEN INC. (USA)
Inventor Poirier, Michael

Abstract

A whole blood treatment device includes a cartridge configured to receive whole blood, having a wall defining an interior volume, an inlet, and an outlet, a support structure having a surface, inside of the cartridge, and an affinity agent, attached to the surface of the support structure. The affinity agent is effective to bind to a target agent that is desirable for removal from a patient. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals. A method of removing a target agent from whole blood of a patient in a whole blood treatment device comprising pumping whole blood into a cartridge, containing a support structure having a surface, with a plurality of affinity agents on the support structure, to contact the whole blood with the affinity agents; binding the target agent with the affinity agents; and removing the whole blood having a reduced amount of the target agent from the cartridge. The target agent is selected from the group consisting of: inhibitory checkpoint molecules, inflammatory factors, cancerous cells, autoantibodies, opioids and heavy metals.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • A61P 39/06 - Free radical scavengers or antioxidants

20.

Devices and methods for on-line whole blood treatment

      
Application Number 15913729
Grant Number 10744258
Status In Force
Filing Date 2018-03-06
First Publication Date 2020-08-18
Grant Date 2020-08-18
Owner Qualigen Inc. (USA)
Inventor Poirier, Michael

Abstract

A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.

IPC Classes  ?

  • A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M 5/165 - Filtering accessories, e.g. blood filters, filters for infusion liquids
  • B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
  • B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
  • B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
  • A61M 27/00 - Drainage appliances for wounds, or the like

21.

Sample port

      
Application Number 29605786
Grant Number D0865210
Status In Force
Filing Date 2017-05-30
First Publication Date 2019-10-29
Grant Date 2019-10-29
Owner Qualigen, Inc. (USA)
Inventor
  • Poirier, Michael
  • Middleton, John Stephen
  • Ballentine, James Wallace
  • Poirier, Suzanne Marie

22.

System and method of using multi-chambered receptacles

      
Application Number 16233927
Grant Number 11235295
Status In Force
Filing Date 2018-12-27
First Publication Date 2019-05-02
Grant Date 2022-02-01
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A method of processing a sample in a receptacle comprising a plurality of chambers. Each of the chambers is connected to at least one other chamber by a portal and at least a first one of the chambers is formed of a flexible material. The method includes the steps of causing gas bubbles contained in the first chamber to accumulate in a portion of the first chamber, applying a compressive external force to the first chamber to cause some or all of the liquid contents of the first chamber to flow into an interconnected second chamber through a portal connecting the first and second chambers; and preventing the gas bubbles accumulated in a portion of the first chamber from flowing through the portal into the second chamber.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • G01N 21/64 - Fluorescence; Phosphorescence
  • B01F 15/00 - Accessories for mixers
  • G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01F 3/12 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with solids
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

23.

Systems and methods for sample verification

      
Application Number 15755868
Grant Number 10650527
Status In Force
Filing Date 2015-09-04
First Publication Date 2018-11-29
Grant Date 2020-05-12
Owner Qualigen, Inc. (USA)
Inventor
  • Poirier, Michael
  • Middleton, John Stephen
  • Poirier, Suzanne Marie

Abstract

The inventive subject matter is directed to point-of-care analytical devices that accurately determine the volume of test samples using image analysis to improve the accuracy of test results performed on the sample. Most preferably, the image analysis is based on rate changes in optical saturation that parallels sample saturation in a porous structure containing the sample.

IPC Classes  ?

  • G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
  • G06T 7/13 - Edge detection
  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01N 21/59 - Transmissivity
  • G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials
  • G01F 1/00 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
  • G01N 21/84 - Systems specially adapted for particular applications

24.

Reagent pack

      
Application Number 29605790
Grant Number D0830573
Status In Force
Filing Date 2017-05-30
First Publication Date 2018-10-09
Grant Date 2018-10-09
Owner Qualigen, Inc. (USA)
Inventor
  • Poirier, Michael
  • Middleton, John Stephen
  • Ballentine, James Wallace
  • Poirier, Suzanne Marie

25.

Whole blood analytic device and method therefor

      
Application Number 15493061
Grant Number 09903799
Status In Force
Filing Date 2017-04-20
First Publication Date 2017-08-03
Grant Date 2018-02-27
Owner Qualigen, Inc. (USA)
Inventor
  • Poirier, Michael
  • Middleton, John Stephen
  • Poirier, Suzanne Marie

Abstract

Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.

IPC Classes  ?

  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
  • G01N 1/40 - Concentrating samples
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties

26.

System and method of using multi-chambered receptacles

      
Application Number 15485330
Grant Number 10688458
Status In Force
Filing Date 2017-04-12
First Publication Date 2017-08-03
Grant Date 2020-06-23
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • G01N 21/64 - Fluorescence; Phosphorescence
  • B01F 15/00 - Accessories for mixers
  • G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01F 3/12 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with solids
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

27.

SYSTEMS AND METHODS FOR SAMPLE VERIFICATION

      
Application Number US2015048582
Publication Number 2017/039690
Status In Force
Filing Date 2015-09-04
Publication Date 2017-03-09
Owner QUALIGEN, INC. (USA)
Inventor
  • Poirier, Michael
  • Middleton, John Stephen
  • Poirier, Suzanne Marie

Abstract

The inventive subject matter is directed to point-of-care analytical devices that accurately determine the volume of test samples using image analysis to improve the accuracy of test results performed on the sample. Most preferably, the image analysis is based on rate changes in optical saturation that parallels sample saturation in a porous structure containing the sample.

IPC Classes  ?

  • G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
  • G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials
  • G01N 33/487 - Physical analysis of biological material of liquid biological material
  • G06T 7/00 - Image analysis

28.

Whole blood analytic device and method therefor

      
Application Number 14398409
Grant Number 09664668
Status In Force
Filing Date 2012-05-03
First Publication Date 2015-03-26
Grant Date 2017-05-30
Owner QUALIGEN, INC. (USA)
Inventor
  • Poirier, Michael
  • Middleton, John Stephen
  • Poirier, Suzanne Marie

Abstract

Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.

IPC Classes  ?

  • G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 1/40 - Concentrating samples
  • B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties

29.

WHOLE BLOOD ANALYTIC DEVICE AND METHOD THEREFOR

      
Application Number US2012036248
Publication Number 2013/165420
Status In Force
Filing Date 2012-05-03
Publication Date 2013-11-07
Owner QUALIGEN, INC. (USA)
Inventor Poirier, Michael

Abstract

Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.

IPC Classes  ?

  • G01N 33/49 - Physical analysis of biological material of liquid biological material blood
  • G01N 1/28 - Preparing specimens for investigation
  • B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value

30.

Instruments and methods for mixing the contents of a detection chamber

      
Application Number 13414195
Grant Number 08491178
Status In Force
Filing Date 2012-03-07
First Publication Date 2012-09-13
Grant Date 2013-07-23
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having interconnected chambers arranged to permit multiple process steps to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • B01F 15/00 - Accessories for mixers
  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation

31.

Sample injection port for laminated devices

      
Application Number 13125733
Grant Number 09144419
Status In Force
Filing Date 2009-10-23
First Publication Date 2011-12-08
Grant Date 2015-09-29
Owner Qualigen, Inc. (USA)
Inventor
  • Poirier, Michael Scot
  • Moulds, Andrew

Abstract

Contemplated diagnostic test containers and methods include an adapter configured to sealingly receive and retain a positive displacement pipette tip to so form a fluid-tight seal for the container during at least part of the diagnostic test. Most preferably, the entire container is flexible and the container and adapter are single-use disposable and are usable with known commercially available positive displacement pipette tips.

IPC Classes  ?

  • G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
  • B01L 3/02 - Burettes; Pipettes

32.

Instruments and methods for mixing the contents of a detection chamber

      
Application Number 13181850
Grant Number 08480976
Status In Force
Filing Date 2011-07-13
First Publication Date 2011-11-10
Grant Date 2013-07-09
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

33.

Gravity-assisted mixing methods

      
Application Number 13078348
Grant Number 08052929
Status In Force
Filing Date 2011-04-01
First Publication Date 2011-08-04
Grant Date 2011-11-08
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector.

IPC Classes  ?

  • G01N 15/06 - Investigating concentration of particle suspensions

34.

IMPROVED SAMPLE INJECTION PORT FOR LAMINATED DEVICES

      
Application Number US2009061820
Publication Number 2010/048494
Status In Force
Filing Date 2009-10-23
Publication Date 2010-04-29
Owner QUALIGEN, INC. (USA)
Inventor
  • Poirier, Michael, Scot
  • Moulds, Andrew

Abstract

Contemplated diagnostic test containers and methods include an adapter configured to sealingly receive and retain a positive displacement pipette tip to so form a fluid-tight seal for the container during at least part of the diagnostic test. Most preferably, the entire container is flexible and the container and adapter are single-use disposable and are usable with known commercially available positive displacement pipette tips.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

35.

Methods and instruments for processing a sample in a multi-chambered receptacle

      
Application Number 12333334
Grant Number 08765367
Status In Force
Filing Date 2008-12-12
First Publication Date 2009-06-04
Grant Date 2014-07-01
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01D 21/00 - Separation of suspended solid particles from liquids by sedimentation
  • G01N 1/18 - Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

36.

Instruments and methods for exposing a receptacle to multiple thermal zones

      
Application Number 12333484
Grant Number 07767447
Status In Force
Filing Date 2008-12-12
First Publication Date 2009-06-04
Grant Date 2010-08-03
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Poirier, Michael S.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

37.

Gravity-assisted mixing methods

      
Application Number 12333335
Grant Number 08048375
Status In Force
Filing Date 2008-12-12
First Publication Date 2009-05-28
Grant Date 2011-11-01
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.
  • Fan, Sara H.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector.

IPC Classes  ?

  • G01N 15/06 - Investigating concentration of particle suspensions

38.

Instruments and methods for mixing the contents of a detection chamber

      
Application Number 12333482
Grant Number 07780336
Status In Force
Filing Date 2008-12-12
First Publication Date 2009-05-28
Grant Date 2010-08-24
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • B01F 15/06 - Heating or cooling systems
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

39.

Multi-chambered receptacles

      
Application Number 12333356
Grant Number 10744469
Status In Force
Filing Date 2008-12-12
First Publication Date 2009-05-28
Grant Date 2020-08-18
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
  • B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
  • B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
  • G01N 21/64 - Fluorescence; Phosphorescence
  • B01F 15/00 - Accessories for mixers
  • G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
  • C12Q 1/6844 - Nucleic acid amplification reactions
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • B01F 3/12 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with solids
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

40.

Methods of concentrating an analyte

      
Application Number 12333455
Grant Number 08735055
Status In Force
Filing Date 2008-12-12
First Publication Date 2009-05-28
Grant Date 2014-05-27
Owner
  • Gen-Probe Incorporated (USA)
  • Qualigen, Inc. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
  • G01N 1/18 - Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
  • G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

41.

INSTRUMENT AND RECEPTACLES FOR USE IN PERFORMING PROCESSES

      
Document Number 02691197
Status In Force
Filing Date 2008-06-20
Open to Public Date 2008-12-31
Grant Date 2013-03-12
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Kacian, Daniel L.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materi-als, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/38 - Temperature-responsive control
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

42.

RECEPTACLES FOR STORING SUBSTANCES IN DIFFERENT PHYSICAL STATES

      
Document Number 02743405
Status In Force
Filing Date 2008-06-20
Open to Public Date 2008-12-31
Grant Date 2012-07-03
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Kacian, Daniel L.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A closed receptacle having a plurality of interconnected chambers is provided for holding liquid and dried substances. The chambers include directly connected first and second chambers. Water vapor passes from the first chamber at a faster rate than it passes from the second chamber. The first chamber contains a dried substance and the second chamber contains a liquid substance capable of altering the state or a characteristic of the dried substance.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • C12M 1/38 - Temperature-responsive control
  • C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

43.

INSTRUMENTS AND METHOD FOR EXPOSING A RECEPTACLE TO MULTIPLE THERMAL ZONES

      
Document Number 02743477
Status In Force
Filing Date 2008-06-20
Open to Public Date 2008-12-31
Grant Date 2012-07-03
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Poirier, Michael S.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

An instrument for processing a sample in a receptacle having a plurality of interconnected chambers is provided. The instrument has thermal elements defining a multiple chamber thermal zone in thermal communication with the receptacle and which to transmit thermal energy between each multiple chamber thermal zone and an associated region of the receptacle. The associated region encompasses all or a portion of each of two or more but less than all chambers. A controller is programmed to control operation of the thermal elements to heat or cool the chambers. A method for heating or cooling substances within the receptacle is also provided where the receptacle is positioned in thermal communication with chamber thermal zones contained in an analyzer and thermal energy is transmitted between each multiple chamber thermal zone and the chambers to heat or cool substances contained within the chambers to a temperature different than the temperature of other chambers.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12M 1/38 - Temperature-responsive control
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

44.

METHODS OF CONCENTRATING AN ANALYTE

      
Document Number 02754884
Status In Force
Filing Date 2008-06-20
Open to Public Date 2008-12-31
Grant Date 2013-04-30
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.
  • Fan, Sara H.

Abstract

Various embodiments of this invention provide a method of concentrating an analyte contained in a fluid sample provided to a receptacle having a plurality of interconnected chambers, the method comprising the steps of: (a) forming a first volume in a first chamber of the receptacle, the first volume comprising the fluid sample and a liquid reagent containing a solid support; (b) immobilizing the analyte on the solid support; (c) moving an aliquot of the first volume from the first chamber to a directly connected second chamber of the receptacle, wherein the volume capacity of the second chamber is less than the first volume; and (d) removing non-analyte components of the sample from the second chamber while retaining the analyte in the second chamber. Steps (c) through (d) are repeated while retaining the analyte in the second chamber thereby accumulating concentrated analyte in the second chamber.

IPC Classes  ?

  • G01N 1/40 - Concentrating samples
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/38 - Temperature-responsive control
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

45.

INSTRUMENT AND RECEPTACLES FOR USE IN PERFORMING PROCESSES

      
Application Number US2008007685
Publication Number 2009/002447
Status In Force
Filing Date 2008-06-20
Publication Date 2008-12-31
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Kacian, Daniel L.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms

46.

METHOD OF PROCESSING A SAMPLE IN A RECEPTACLE HAVING A PLURALITY OF INTERCONNECTED CHAMBERS

      
Document Number 02743365
Status In Force
Filing Date 2008-06-20
Open to Public Date 2008-12-31
Grant Date 2012-07-03
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Fan, Sara H.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A method of processing a sample in a receptacle having a plurality of interconnected chambers is provided. A sample is provided to a first chamber. In separate chambers of the receptacle, combinations are made using: at least some of the sample in the first chamber and at least some of a sample processing reagent in a second chamber of the receptacle; at least some of a substance contained in a third chamber and at least some of a substance contained in a fourth chamber; and, at least some of a substance contained in a fifth chamber and at least some of a substance contained in a sixth chamber. Afterwards, a component of the sample is combined in a chamber with at least some of each of the aforementioned combinations.

IPC Classes  ?

  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
  • C12M 1/38 - Temperature-responsive control
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

47.

MULTI-CHAMBERED RECEPTACLES

      
Document Number 02743404
Status In Force
Filing Date 2008-06-20
Open to Public Date 2008-12-31
Grant Date 2012-11-06
Owner
  • GEN-PROBE INCORPORATED (USA)
  • QUALIGEN, INC. (USA)
Inventor
  • Breidenthal, Scott S.
  • Lee, Richard S.
  • Nelson, Norman C.
  • Scott, Matthew J.
  • Taylor, Jason A.

Abstract

A multi-chambered receptacle for use in processing a sample is provided. The receptacle has a plurality of linear paths of chambers. The chambers of each path are interconnected by a plurality of openable connections. The receptacle also has opposed members, at least one of which members comprises a flexible sheet.

IPC Classes  ?

  • G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
  • C12M 1/38 - Temperature-responsive control
  • C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

48.

DIFFERENTIAL HEAT SEAL STRENGTH IN POUCH-BASED PRODUCTS

      
Application Number US2007025171
Publication Number 2008/070190
Status In Force
Filing Date 2007-12-06
Publication Date 2008-06-12
Owner QUALIGEN, INC. (USA)
Inventor
  • Taylor, Jason Anthony
  • Poirier, Michael Scot
  • Breidenthal, Scott Stephen
  • Scott, Matthew James

Abstract

Devices and methods are contemplated in which pouch-based diagnostic and medical products are formed in a process that allows formation of distinct seals using application of distinct process control variables for the respective seals. Therefore, products having stronger permanent seals and at the same tome frangible seals with controlled breaking characteristics can be prepared in s simple and reproducible manner.

IPC Classes  ?

  • B31B 1/64 - Uniting opposed surfaces or edges; Taping by applying heat or pressure
  • B31B 49/04 - Machinery, accessories or processes not provided for in groups for making envelopes or bags

49.

QUALIGEN

      
Serial Number 77327911
Status Registered
Filing Date 2007-11-13
Registration Date 2008-07-15
Owner Qualigen, Inc. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Automated diagnostic kits comprised of diagnostic reagents and assays for testing body fluids

50.

IMPROVED FLUID PORT FOR LAMINATED DEVICES

      
Application Number US2007009118
Publication Number 2007/120816
Status In Force
Filing Date 2007-04-12
Publication Date 2007-10-25
Owner QUALIGEN, INC. (USA)
Inventor Breidenthal, Scott Stephen

Abstract

A container is formed from flexible top and bottom sheets and further includes an energy-deformable conduit. Contemplated containers include a plurality of compartments and a sample receiving compartment, wherein the conduit allows feeding a fluid into the sample compartment without feeding the fluid in the remaining compartments, which is preferably achieved by a flow-restriction portion in the conduit and a flow-control element between the sample receiving compartment and one or more of the compartments.

IPC Classes  ?

  • B65D 30/22 - Sacks, bags or like containers characterised by shape or construction with two or more compartments

51.

FASTPACK

      
Serial Number 75399007
Status Registered
Filing Date 1997-12-02
Registration Date 2000-12-12
Owner QUALIGEN, INC. ()
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

kits composed of clear cartridges pre-filled with diagnostic reagents into which fluids are introduced and through which they are transported to come into contact with the reagents in a manner in which the reaction can be observed and the result read