THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Matzdorf, Craig
Grieve, Alan
Abstract
The aluminum anode alloy consists essentially of an aluminum base and effective amounts of tin and indium. The aluminum alloy is useful as a sacrificial metallic coating, as a protective aluminum anode, and as a pigment in polymeric coatings.
C23C 30/00 - Coating with metallic material characterised only by the composition of the metallic material, i.e. not characterised by the coating process
2.
COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF ANEMIA
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Venn-Watson, Stephanie Kay
Baird, Mark
Abstract
Compositions including a fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to anemic conditions, are provided, including compositions and methods for treating anemic conditions such as hemolytic anemia and anemia of chronic disease, and other related conditions.
A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Venn-Watson, Stephanie Kay
Abstract
Compositions including an fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to inflammation and conditions related to inflammation, including anemia of chronic disease, insulin resistance, metabolic syndrome, autoimmune disease, hypertension, diabetes, nonalcoholic fatty liver disease, cardiovascular disease, cancer, aging, neurodegenerative diseases, including Alzheimer's disease and other forms of dementia, and other related conditions, and other related conditions.
A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 5/50 - Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
A61P 9/00 - Drugs for disorders of the cardiovascular system
A61P 25/00 - Drugs for disorders of the nervous system
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Biswas, Biswajit
Henry, Matthew S.
Regeimbal, James M.
Abstract
The subject matter of the instant invention relates to methods of compounding compositions comprising bacteriophage effective for treating bacterial infections, including but not limited to, multidrug resistant bacterial infections. The invention also relates to compositions, bacterial diversity sets, and phage libraries prepared according to the methods of the instant invention.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Sinfield, Matthew
Farren, Jeffrey
Wong, Richard
Martin, William J.
Smith, Richard H.
Para, Shane
Heilmann, James E.
Novotny, Paul M.
Ray, Patrick C.
Deantonio, Dan
Stravinskas, Joe
Abstract
An exemplary welding consumable according to the invention is provided and includes up to about 0.13 wt % carbon, about 0.3 wt % to about 1.4 wt % manganese, about 7.25 wt% to about 11.5 wt % nickel, about 0.6 wt % to about 1.2 wt % molybdenum, about 0.2 wt % to about 0.7 wt % silicon, up to about 0.3 wt % vanadium, up to about 0.05 wt % titanium, up to about 0.08 wt % zirconium, up to about 2.0 wt % chromium, and a balance of iron and incidental impurities.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Guerry, Patricia
Savarino, Stephen
Monteiro, Mario Artur
Abstract
The inventive subject matter relates to a construct comprising antigens derived from multiple enterobacteria including Campylobacter jejuni capsule polysaccharide polymer, enterotoxigenic Escherichia coli recombinant polypeptide construct and lipopolysaecharide from Shigella spp.. The subject invention also relates to a method of inducing an immune response utilizing the inventive composition.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Guerry, Patricia
Monteiro, Mario Artur
Abstract
The inventive subject matter relates to an immunogenic composition against Campylobacter jejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacter jejuni strains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing and anti-C. jejuni immune response.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Savarino, Stephen
Abstract
The inventive subject matter relates to a recombinant polypeptide construct comprising enterotoxigenic Escherichia coli fimbrial subunits. The recombinant polypeptide constructs comprise multiple subunits to the same or different ETEC fimbrial types. The constructs are useful for inclusion in immunogenic formulations for the inductin of immunity against entertoxigenic Escherichia coli. The inventive subject matter also relates to the use of the recombinant polypeptide constructs in induce anti- enterotoxigenic Escherichia coli.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Matzdorf, Craig A.
Nickerson, William
Abstract
Sacrificial-metal pigments are coated with an effective amount of at least one metal oxide or a combination of metal oxides such as a chromium-zirconium oxide, and the process for preparing said coated pigments and combination thereof with film-forming binders for coating metal substrates to inhibit corrosion. The coated sacrificial-metal pigments are electrically active to prevent corrosion of metal substrates that are more.
C23C 22/06 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH < 6
C23F 11/10 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using organic inhibitors
10.
ALUMINUM ALLOY COATED PIGMENTS AND CORROSION-RESISTANT COATINGS
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Matzdorf, Craig A.
Nickerson, William
Abstract
This Invention relates to galvanic aluminum alloy powder-figments coated with a semi-conducting corrosion inhibiting oxide ad the process for preparing said coated powder-pigments in combination with film-forming binders for coating metal substrates to inhibit corrosion. The coated aluminium alloy powder-pigments are electrically active aid prevent corrosion of metals which are more catholic (electropositive) than the aluminium alloy pigments;
C09D 5/10 - Anti-corrosive paints containing metal dust
C23C 22/00 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
C23F 11/00 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent
11.
PLASMODIUM FALCIPARUM SPOROZOITE AND LIVER STAGE ANTIGENS
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Limbach, Keith
Aguiar, Joao
Sedegah, Martha
Richie, Thomas
Abstract
The invention provides novel malaria polypeptides expressed at the preerythrocytic stage of the malaria life-cycle. The antigens can be utilized to induce an immune response against malaria in a mammal by administering the antigens in vaccine formulations or expressing the antigens in DNA or other nucleic acid expression systems delivered as a vaccine formulation.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Limbach, Keith
Aguiar, Joao
Sedegah, Martha
Richie, Thomas
Abstract
The invention provides novel malaria polypeptides expressed at the pre- erythrocytic stage of the malaria life-cycle. The antigens can be utilized to induce an immune response against malaria in a mammal by administering the antigens in vaccine formulations or expressing the antigens in DNA or other nucleic acid expression systems delivered as a vaccine formulation.
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
UNIVERSITY OF GUELPH (Canada)
Inventor
Guerry-Kopecko, Patricia
Monteiro, Mario Artur
Abstract
An immunogenic composition, and method of using the composition to elicit an immune response to Campylobacter jejuni. The composition is an isolated polysaccharide polymer composed of one or more forms of disaccharide polymers.
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Matzdorf, Craig A.
Nickerson, William C., Jr.
Abstract
This invention comprises an acidic aqueous solution for treating metal substrates to improve the adhesion bonding and corrosion protection of the metal surface which comprises effective amounts of water soluble trivalent chromium compounds, fluorozirconates, effective amounts of at least one corrosion inhibitors such as benzotriazole, fluorometallic compounds, zinc compounds, thickeners, surfactants, and at least about 0.001 mole per liter of the acidic solution of a polyhydroxy and/or carboxylic compound as a stabilizing agent for the aqueous solution.
C23C 22/34 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH < 6 containing fluorides or complex fluorides
C23C 22/50 - Treatment of iron or alloys based thereon
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Savarino, Stephen J.
Abstract
The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive subject matter also relates to the use Escherichia coli adhesins as immunogens and to the construction of conformationally stability and protease resistant Escherichia coli adhesin constructs useful for inducing immunity to Escherichia coli pathogenic bacteria. The methods provide for the induction of B-cell mediated immunity and for the induction of antibody capable of inhibiting the adherence and colonization of Escherichia.coli, including. enterotoxigenic Escherichia coli, to human cells.
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Matzdorf, Craig A.
Nickerson, William C., Jr.
Abstract
Pretreated aluminum and aluminum alloys and the process and composition for pretreating said aluminum and its alloys to provide a coating with color recognition for identification purposes and to improve the corrosion- resistance, electrical conductivity, and adhesion properties which comprises pretreating said aluminum and its alloys with an effective amount of an acidic aqueous solution having a pH ranging from about 2.5 to 5.5 comprising water soluble trivalent chromium compounds, alkali metal hexafluorozirconates, divalent zinc compounds, alkali metal fluoro-compounds, and effective amounts of water soluble thickeners, surfactants or wetting agents.
C23C 22/05 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
C23C 22/34 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH < 6 containing fluorides or complex fluorides
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
Inventor
Matzdorf, Craig A.
Nickerson, William C., Jr.
Abstract
Aqueous compositions for post treating metal coated substrates such as cadmium- plated steel, and zinc-nickel coated substrates and the process for using said compositions to provide a color recognizable coating and, to improve the corrosion-resistance, abrasion, electrical, and adhesion properties of the coating. The post-treatment composition comprises an acidic aqueous solution having a pH ranging from about 2.5 to 5.5 and contains effective amounts of trivalent chromium compounds, alkali metal hexafluorozirconates, at least one divalent zinc compound, alkali metal fluoro-compounds, and effective amounts of water soluble thickepers, wetting agents or surfactants.
C23C 22/05 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
PYROGENESIS CANADA INC. (Canada)
Inventor
Cofield, Jon William
Nolting, Eugene Ellis
Alexakis, Theodora
Manoliadis, Platon
Tsantrizos, Peter George
Abstract
Solid combustible waste materials are converted into highly efficient fuel by subjecting such materials to size reduction in suitable size-reducing equipment (10, 12). The last piece of the equipment is a mill (14) which pulverizes the waste materials into fine particles having a high surface to mass ratio and forming a highly efficient fuel when these particles are directly injected into a combustion reactor (18) operating at high temperature.