A data processing method, applied to adversarial training of a model. The method comprises: acquiring a first disturbance, wherein the rank of the first disturbance is less than the rank of training data, and the first disturbance is fused with the training data to obtain first data; and according to the first data, obtaining a loss by means of a machine learning model, wherein the loss is used for updating the first disturbance to obtain a second disturbance, the second disturbance is fused with the training data to obtain second data, and the second data is used for updating the machine learning model. According to the present application, a low-rank structure is introduced into a disturbance, such that low-rank false information (or can be called false features) can be better captured and filtered out, and a disturbance can be effectively applied to false features in a training sample, such that the robustness of a trained model to the false features in data can be improved, and then good OOD performance is achieved.
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
G06V 10/774 - Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
2.
METHODS FOR CHEMICAL REPROGRAMMING AND PLURIPOTENT STEM CELLS
Provided herein, in some aspects, are methods and compositions for cell conversion. The methods may convert a cell population comprising one cell type to another cell population comprising another cell type. The converted cell types may have increased cell differentiation potential. The converted cell types can comprise pluripotent stem cells. The compositions provided herein may comprise chemical reprogramming factors for converting cells. The compositions provided herein may comprise chemical reprogramming factors and cells. Also provided herein are reagents for carrying out the methods for converting cells. Additionally, provided herein are methods and compositions for using various cell types obtained by the methods and/or compositions provided herein.
Disclosed in the present invention are an inverse halftoning method and apparatus based on a conditional diffusion network. The method comprises: calculating an image grayscale level and Laplacian prior of a halftone image; under the image grayscale level and the Laplacian prior, performing reverse dithering diffusion for T time steps on at least one initial state (aa), so as to generate a halftone distribution; and under the halftone distribution, performing inverse halftoning diffusion for T' time steps on at least one initial state (bb), so as to obtain an inverse halftoning result of the halftone image. By means of the present invention, the inpainting quality of a print is improved.
The present invention belongs to the technical field of oligosaccharides and glycoconjugates thereof, and specifically relates to a sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, a glycoconjugate and a preparation method therefor. Provided are a nitrogen-linked sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, which has a structure as shown in formula 1. Experiments in mice show that the nitrogen-linked sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof can be coupled with a carrier protein or a polypeptide via different linkers to obtain a glycoprotein (glycopeptide) conjugate, which generates a more effective immune response, and can specifically recognize tumor cells expressing STn, thereby achieving an anti-tumor effect. The present invention provides a new skeleton structure for the research on and development of anti-tumor carbohydrate vaccines, and is expected to promote the development of anti-tumor carbohydrate vaccines.
C07K 14/34 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/385 - Haptens or antigens, bound to carriers
It relates to immune cells (e.g., T cells such as CAR-T cells, NK cells such as CAR-NK cells) modified to have no or reduced expression and/or function of one or more target proteins selected from the group consisting of: Signal Peptide Peptidase Like 3 (SPPL3), FADD, FAS, CASP8, ARID1A, BAK1, BID, ETS1, IKZF2, and HIST1H1B (such as SPPL3), uses thereof, and methods for generating thereof. Also provided are uses of the one or more target proteins (e.g., SPPL3) as a biomarker.
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61P 35/04 - Antineoplastic agents specific for metastasis
Provided herein, in some aspects, are methods and compositions for cell conversion. The methods may convert a cell population comprising one cell type to another cell population comprising another cell type. The converted cell types may have increased cell differentiation potential. The converted cell types can comprise pluripotent stem cells. The compositions provided herein may comprise chemical reprogramming factors for converting cells. The compositions provided herein may comprise chemical reprogramming factors and cells. Also provided herein are reagents for carrying out the methods for converting cells. Additionally, provided herein are methods and compositions for using various cell types obtained by the methods and/or compositions provided herein.
An image processing model training method and apparatus, an image processing method and apparatus, and a device and a medium, which belong to the technical field of computer vision. The image processing model training method comprises: acquiring a sample image (401); inputting the sample image into a teacher image processing model to acquire a first image feature (402); inputting the sample image into a student image processing model to acquire a second image feature, and aligning the second image feature with the first image feature to obtain an aligned image feature (403); by using a first feature transformation model, transforming the aligned image feature to obtain a third image feature (404); on the basis of the difference between the first image feature and the third image feature, acquiring a feature difference loss, and acquiring a training loss on the basis of the feature difference loss (405); and by using the training loss, updating a parameter of the student image processing model to obtain a target image processing model (406).
G06V 10/77 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06N 3/04 - Architecture, e.g. interconnection topology
Methods are provided for determining a transcription factor binding site on genomic double stranded (ds) DNA of a eukaryotic cell or cells by contacting the genomic dsDNA with a dsDNA deaminase under conditions to convert cytosine of the genomic dsDNA to uracil, thereby creating treated genomic dsDNA, and identifying unconverted cytosine on the treated genomic dsDNA as a transcription factor binding site.
C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
9.
HIGH-AFFINITY PD1 PROTEIN CONJUGATE AND USE THEREOF
Provided is a high-affinity PD1 protein conjugate, which comprises an elastin-like polypeptide and a high-affinity PD1 protein connected to the elastin-like polypeptide. The conjugate significantly improves the biological half-life and bioavailability of the high-affinity PD1 protein and has tumor targeting and permeability and tumor microenvironment temperature responsiveness.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A method of realizing a content-addressable memory (CAM) based on field effect transistors having bipolar characteristics. By inserting a storage layer between a gate dielectric layer and a control gate of a field effect transistor having a bipolar characteristic and a source-drain symmetry, the threshold voltage is adjusted for information storage; further, a non-monotonic transfer characteristic of said field effect transistor is used for an input search, thus implementing a linearly inseparable comparison operation required by a CAM unit on a single field effect transistor having a bipolar characteristic adjustable threshold. Compared with the CAM designs based on traditional MOSFETs, the present invention has remarkably reduced unit area and a simpler programming and search operation process, accordingly realizing higher energy efficiency and extra wide application space.
G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using ferroelectric elements
G11C 5/06 - Arrangements for interconnecting storage elements electrically, e.g. by wiring
12.
ADIPOSE TISSUE ADHESIVE FOR REPLACING ABSORBABLE SUTURE, PREPARATION METHOD, AND USE THEREOF
The present disclosure provides an adipose tissue adhesive for replacing an absorbable suture, a preparation method, and use thereof, and belongs to the technical field of hydrogel adhesives. The adipose tissue adhesive comprises a natural polymer, a cross-linking agent, and a topological small molecule. Using the natural polymer as a main network, the adipose tissue adhesive is formed by means of physical crosslinking. By means of the present disclosure, high-strength adhesion to a subcutaneous adipose tissue can be realized with a strength of up to 100 kPa, and it is expected to replace an absorbable suture for subcutaneous adipose closure, thereby solving the problem that it is difficult for a biological adhesive to adhere to a grease tissue. Different from existing adhesion means, an adhesion interface formed by the hydrogel can be gradually strengthened over time, and can maintain the stability and effectiveness of wound closure in a hypersaline environment or under the change of a physiological pH value. The hydrogel is easy to operate, and can be injected into affected parts of various shapes to realize instantaneous closure, thereby further improving the efficiency of wound treatment in first aid, reducing the cost of surgery and the degree of wound infection, and having clinical popularization value.
BEIJING BIOTUNE MEDICAL TECHNOLOGY CO., LTD (China)
PEKING UNIVERSITY (China)
Inventor
Guo, Yuxuan
Chen, Zhan
Abstract
Disclosed are a nucleic acid molecule comprising an alternative splicing regulatory element and a target gene located at the 3' terminus of the alternative splicing regulatory element, a transcript of the nucleic acid molecule, a vector comprising the nucleic acid molecule or the transcript, a recombinant virus, a cell, a pharmaceutical composition, a method for using the same in regulating the expression level of the target gene, and use thereof in gene therapy.
An unsupervised low-illumination-domain adaptive training method and a detection method. The detection method comprises: 1) collecting labeled normal illumination training data, unlabeled low illumination training data and a pre-training model, and connecting a multi-layer perceptron behind a feature extractor of the pre-training model to obtain a first model; 2) training the multi-layer perceptron in the first model by using the normal illumination data; 3) constructing a depth concave curve model, and placing the depth concave curve model in front of a feature extractor in the first model to obtain a second model; 4) training the depth concave curve model in the second model by using the low illumination data; 5) brightening the low illumination data by using the depth concave curve model, inputting the low illumination data into the pre-training model, and taking the predicted label as a pseudo label of the low illumination data; 6) performing training and fine-tuning on the pre-training model by using the normal illumination data and the low illumination data with the pseudo label; and 7) brightening a low illumination image to be processed, inputting the brightened low illumination image to the fine-tuned pre-training model, and outputting a corresponding detection result.
A digital printing device calibration method, comprising: loading the current calibration function to output test data under specific output conditions; measuring a color value of each output color block in a device-independent color space by using a measurement device; calculating the color difference between adjacent color blocks of each colorant; and regenerating a new calibration function. By using the method, the calibration of any colorant can be realized, and the actual imaging effect of an individual colorant is visually approximately uniform.
An in-situ infrared dynamic sensing and in-sensor computing array based on a ferroelectric capacitor. The array is formed by several pixels, and each pixel is composed of several in-sensor computing devices, wherein in-sensor computing devices at the same position in different pixels are connected in parallel by means of connecting lines; and the in-sensor computing device is a deep-trench ferroelectric capacitor that is formed by a bottom electrode, a top electrode and a ferroelectric dielectric material between the two electrodes on an insulating substrate having a deep trench, and the ferroelectric dielectric material changes with temperature to produce a pyroelectric charge response related to the intensity of polarization. The present invention realizes zero-power-consumption in-situ infrared dynamic sensing, and reduces the power consumption and delay overhead of a system, and realizes weighted information sensing, realizes four-quadrant multiplication of sensed information and a weight within a single device, and achieves a complex in-sensor computing function.
The present invention relates to ionic liquids based on non-natural amino acids, a preparation method therefor, and use thereof, and particularly provides a substance combination for preparing a protein containing non-natural amino acids. The substance combination comprises: (1) one or more aminoacyl-tRNA synthetases, which can bind to mutated tRNAs; (2) one or more mutated tRNAs, in which the anticodon loop is mutated into a complementary sequence of the termination codon; and (3) a variety of ionic liquids based on non-natural amino acids. The substance combination can be used for recombination and expression of the protein containing non-natural amino acids. The ionic liquids based on non-natural amino acids can improve the read-through efficiency of genetic codon expansion systems for premature termination codons (PTCs) and/or the efficiency of inserting the non-natural amino acids.
NINGBO INSTITUTE OF MARINE MEDICINE, PEKING UNIVERSITY (China)
PEKING UNIVERSITY (China)
Inventor
Zhou, Demin
Ji, Dezhong
Zhang, Yuanjie
Abstract
The present invention belongs to the field of medicines and relates to a mutated influenza virus, a pharmaceutical composition, and use. Specifically, the present invention relates to a replication-defective influenza virus, a pharmaceutical composition, and use. More specifically, the present invention relates to a mutated influenza virus, wherein nucleic acid encoding HA protein and/or nucleic acid encoding NA protein of the influenza virus comprises one or more UAG codons. The replication-defective influenza virus or the pharmaceutical composition of the present invention can effectively treat or prevent tumors and has good application prospects.
The present invention relates to the field of biomedicine, in particular to the field of regenerative medicine. Specifically, the present invention relates to a compound for preparing myocardial cells and use thereof, and a method for differentiating pluripotent stem cells, such as induced pluripotent stem cells, into myocardial cells by using the compound.
A method for preparing a single crystal nitride Micro-LED array based on a non-single crystal substrate. A two-dimensional material mask layer is prepared to obtain a dislocation filter layer having a dislocation density less than 1×109cm-2, and to further obtain a single crystal nitride thin film having a dislocation density less than 1×108cm-2, so that an ultra-high quality single crystal nitride functional structure can be implemented on a non-single crystal substrate having large lattice mismatch and large coefficient of thermal expansion mismatch. In addition to being used for preparing a Micro-LED device, the method can further be used for preparing a radio frequency device, a power device, a light emitting device, a detection device, and the like, and has process universality. The interface bonding between an epitaxial structure and the non-single crystal substrate is destroyed by using a laser, so that nondestructive separation of the epitaxial structure and repeated utilization of the non-single crystal substrate can be realized, and the method is energy-saving, environment-friendly, and simple, and is suitable for batch production.
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
21.
IMAGE-SENSING OPERATION UNIT AND METHOD FOR OPERATING SAME, AND IMAGE-SENSING ARITHMETIC UNIT AND ELECTRONIC DEVICE
Provided in the present disclosure are an image-sensing operation unit and a method for operating same, and an image sensing arithmetic unit and an electronic device. The image-sensing operation unit comprises a first photosensitive unit and a second photosensitive unit, wherein the second photosensitive unit is connected in series to the first photosensitive unit, and the changing direction of a first threshold voltage of the first photosensitive unit when receiving light is opposite to the changing direction of a second threshold voltage of the second photosensitive unit when receiving light, such that an in-situ logical operation is realized between optical input signals. Therefore, compared with the prior art, the image-sensing operation unit in the embodiments of the present disclosure can directly implement an in-situ logical processing function while performing photoelectric conversion, and therefore the image-sensing operation unit directly outputs an electrical signal representing a corresponding logical operation result. Thus, a traditional signal processing module for logical processing can be omitted, thereby effectively reducing the complexity of a system and improving the efficiency of optical-signal processing.
A method for preparing a large-size nitride bulk single crystal by using a single crystal two-dimensional material. A carrier nitride substrate is obtained by combining polycrystalline nitride primitives, a single crystal expansion layer and a single crystal cut-off layer are prepared on a two-dimensional material transferred from the upper surface and the lower surface of the carrier nitride substrate, a large-size nitride bulk single crystal having a centimeter-level thickness and a diameter of more than one hundred micrometers may be prepared by constructing a high-temperature high-pressure temperature gradient field to induce a single crystallization process from a single crystal AlN inducer to the whole nitride structure, and different nitride bulk single crystals such as GaN or AlN are prepared; a nitride bulk single crystal having extremely high crystal quality may be obtained by inducing recrystallization by means of a super high-quality single crystal AlN inducer, which features low process complexity and is suitable for mass production. The described method is applicable to the production industry of nitride semiconductor single crystal substrates; after a nitride bulk single crystal is cut, same may be used as a substrate for manufacturing high-performance light-emitting devices and electronic devices, and has important applications in various fields, such as laser illumination, radio frequency communication, and the like.
A method for nitride LED preparation and non-destructive interface separation. An atomic irradiation technology is used to modify a two-dimensional atomic crystal layer on a transparent substrate to obtain an irradiation region; a nitride LED structure is prepared on the modified two-dimensional atomic crystal layer, and then a support substrate is fixed by means of a metal functional layer; and visible laser light is incident from the back surface of the transparent substrate to directionally destroy the irradiation region of the two-dimensional atomic crystal layer, so as to obtain the overall structure of the nitride LED structure, the metal functional layer and the support substrate separated from the transparent substrate. The present invention can realize non-destructive interfacial separation and reuse of a transparent substrate, is compatible with nitride LED and Micro-LED epitaxial and machining processes, and is applied to manufacturing and separation of a wafer-level nitride LED and a micron-scale Micro-LED array, a nitride sacrificial layer is not required to be provided in advance, and an additional grinding and polishing process is not needed. The present invention is energy-saving and environmentally friendly, has a simple process and is suitable for mass production.
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
24.
MONOLITHIC INTEGRATION PREPARATION METHOD FOR FULL-COLOR NITRIDE SEMICONDUCTOR MICRO-LED ARRAY
A monolithic integration preparation method for a full-color nitride semiconductor Micro-LED array. The method comprises: firstly preparing a composite conductive substrate; then, covering the composite conductive substrate with an insulating template to prepare a template substrate; covering the template substrate with monocrystalline graphene in a completely aligned manner so as to obtain a customized template graphene substrate, which comprises graphene array elements, wherein a blue-region graphene array element, a green-region graphene array element and a red-region graphene array element of each graphene array element have different surface properties; performing one-step in-situ epitaxial growth of all nitrides of a vertical structure to obtain a full-color Micro-LED array epitaxial wafer in situ in one step; and finally, packaging and preparing a transparent electrode so as to obtain a full-color nitride Micro-LED array, which has a vertical structure and emits light from the top face. The present invention does not need an additional micro-nano machining process, is energy-saving and environmentally friendly, is suitable for batch production, and is applied in display chips for enhanced/virtual reality, 8K super-definition display, etc.
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
25.
IMAGE PROCESSING METHOD AND APPARATUS, ELECTRONIC DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM
The present application relates to the technical field of artificial intelligence, and discloses an image processing method and apparatus, an electronic device, and a computer-readable storage medium. The image processing method comprises: acquiring a first watermark generated for a deepfake model and a second watermark carrying target information; acquiring a target coding model, the target coding model being used for performing watermark embedding on an image; and embedding the first watermark and the second watermark into an initial image by means of the target coding model to obtain a target image, a difference between the initial image and the target image being less than a reference threshold.
A heterogeneous multi-agent networking cooperative scheduling planning method based on autonomous obstacle bypassing. The method comprises: performing system configuration and transportation task management for multi-agent networking cooperative scheduling planning; performing cooperative path searching on each agent, which is about to execute a transportation task, in a system to obtain a corresponding path list; the agent performing motion planning to obtain an execution path; performing calculation according to the execution path to obtain a traveling speed; the agent performing autonomous obstacle bypassing during an operation process; and adjusting a time window. By using a time window algorithm and introducing the autonomous obstacle bypassing technology of agents, the present invention realizes the cooperative resolution of conflicts between the agents and autonomous obstacle bypassing, is more efficient, flexible and robust, and can involve more agents that can be accommodated in a system.
xy22, where 0.6 ≤ x ≤ 1, and 0 ≤ y ≤ 0.1. Lithium ions and adjacent oxygen ions form tetrahedral coordination; and in an X-ray diffraction spectrum thereof, a main peak occurs between 17.9º and 18.1º, and a strong 131 crystal plane diffraction peak occurs within 67.0º-67.5º, which is a characteristic peak of the space group Cmca. The preparation method comprises: first synthesizing a precursor, i.e., P2-phase layered sodium cobalt oxide, by means of a solid-phase ball milling method or a coprecipitation method, and then subjecting same to ion exchange to obtain a T2-type lithium cobalt oxide layered positive electrode material.
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
Provided in the description is a liquid crystal/polymer composite electrically-controlled switchable film. The liquid crystal/polymer composite electrically-controlled switchable film comprises a liquid crystal material, a polymer matrix, and two layers of an ITO conductive film. The polymer matrix is sandwiched between the two layers of the ITO conductive film and is of a porous microstructure. The liquid crystal material is dispersed in the polymer matrix to form liquid crystal microdroplets, and the liquid crystal microdroplets have a vertically-oriented polymer network. The liquid crystal/polymer composite electrically-controlled switchable film has a unique composite microstructure; and in the composite microstructure, the polymer matrix of the porous microstructure endows the film with good mechanical processing performance, and moreover the vertically-oriented polymer network in the liquid crystal microdroplets further reduces the orientation difficulty of liquid crystal molecules, such that the driving voltage of the liquid crystal/polymer composite electrically-controlled switchable film is reduced, and the liquid crystal/polymer composite electrically-controlled switchable film is suitable for large-scale processing and production.
G02F 1/137 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering
G02F 1/1334 - Constructional arrangements based on polymer-dispersed liquid crystals, e.g. microencapsulated liquid crystals
C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
C08L 29/10 - Homopolymers or copolymers of unsaturated ethers
The present disclosure provides an operating method, apparatus, and device for an in-memory computing architecture for use in a neural network. The operating method comprises: generating a single pulse input signal encoded on the basis of discrete time; inputting the single pulse input signal into a memory array of an in-memory computing architecture so as to generate a bit line current signal corresponding to the memory array; and controlling a neuron circuit of the in-memory computing architecture to output, according to the bit line current signal, a single pulse output signal encoded on the basis of discrete time, the single pulse output signal acting as a single pulse input signal in a next in-memory calculation cycle of the memory array of a next layer of a neural network. Therefore, a single pulse input into the in-memory calculation architecture can be implemented by means of the single pulse input signal encoded on the basis of discrete time, thereby greatly reducing the number of input pulses and greatly reducing dynamic power consumption of the memory array and the neuron circuit.
Provided in the present invention are a video transmission quality evaluation and optimization method and system based on user behavior indexes. The method comprises: establishing an exit rate model according to a session duration of a user watching a video, and a playing state of each second; calculating a state transition probability according to playing states of every two adjacent seconds; according to the transition probability and the exit rate, calculating mathematical expectation values of stay durations corresponding to positions, network connection types, CDNs and bitrates within different time periods; and according to a stay duration expectation, for the position and a network connection type of a given user, selecting a bitrate and a CDN which allow the longest stay duration expectation. By means of the present invention, a model is established on the basis of two user behavior indexes, i.e. an exit rate and a stay duration, and video transmission quality scores corresponding to different bitrates and CDNs are evaluated for the specific positions and network connection types of different users, such that a bitrate and a CDN which can optimize the viewing experience of a user are accurately given, and the video transmission quality can be greatly improved.
H04N 21/44 - Processing of video elementary streams, e.g. splicing a video clip retrieved from local storage with an incoming video stream or rendering scenes according to MPEG-4 scene graphs
The present invention relates to the technical field of genetic engineering, and in particular to an anti-senescent drug screening method. The screening method comprises: treating a GFP-progerin protein overexpressing cell by using a drug to be screened; comparing the treated GFP-progerin protein overexpressing cell with a GFP-progerin protein overexpressing cell that is not treated by the drug to be screened; and determining, according to a change in cell morphology, an anti-senescent function of the drug to be screened. The present invention finds that a progerin protein positioned on a nuclear membrane can cause a cell to show obvious characteristics of senescence, including nuclear membrane shrinkage and nuclear membrane budding. However, a progerin protein positioned in a cell nucleus would not cause a cell to show obvious characteristics of senescence. If a drug has an anti-senescent effect, a progerin protein positioned on a nuclear membrane would be transferred into a cell nucleus. On this basis, the present invention provides an anti-senescent drug screening method, capable of accurately and efficiently screening out an anti-senescent drug.
Disclosed is use of chaetocin in anti-aging. The present invention adopts an aging cell model and an aging mouse model to screen and obtain a drug, chaetocin, which has the effect of anti-aging. By means of cell and mouse experiment verification, chaetocin not only can effectively inhibit alopecia, weight loss, cardiac fibrosis, liver fibrosis, renal fibrosis, spleen fibrosis, pulmonary fibrosis, adventitial fibrosis, and smooth muscle loss, but can also prolong the life span, increase abdominal fat, and alleviate cardiac inflammation, renal inflammation, liver inflammation, pulmonary inflammation, spleen inflammation, small intestine inflammation, and skin inflammation. Chaetocin provided by the present invention can be used as an anti-aging drug, and is applied to research and development of various drugs for treating aging-related diseases.
A61K 31/548 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame having two or more sulfur atoms in the same ring
A61P 39/00 - General protective or antinoxious agents
A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
A61P 43/00 - Drugs for specific purposes, not provided for in groups
33.
USE OF IMMUNE EFFICACY OR CLINICAL RELATIVE IMMUNE EFFICACY IN EVALUATION OF VACCINE RESPONSE STRENGTH OF SUBJECT
Disclosed is use of an RPN11 marker in the detection of myeloma and disease risk thereof, prognosis analysis and a treatment medicament, comprising: a detection reagent and a kit for detecting smoldering myeloma, multiple myeloma and disease risk thereof, molecular typing of patients with multiple myeloma, prognosis analysis of the patients with multiple myeloma, and predicting the treatment reactivity to bortezomib of multiple myeloma patients, and use of an RPN11 inhibitor in the preparation of a pharmaceutical composition for treating drug-resistant t(4; 14) translocation and RPN11 high-expression multiple myeloma. In particular, combining the RPN11 and histone methyltransferase MMSET provides more sensitive and accurate detection performance, avoids situations of patient genotype not matching disease development predictions, while total survival and prognosis conditions of MM patients with t(4;14) translocation can be effectively predicted. Furthermore, the pharmaceutical composition has a synergistic effect, thereby effectively promoting the apoptosis of the multiple myeloma cells with t(4;14) translocation.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 31/00 - Medicinal preparations containing organic active ingredients
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Disclosed in the present invention is a low-illumination image enhancement method using long-exposure compensation. The method comprises: 1) collecting a low-illumination training data set, wherein each training sample in the low-illumination training data set comprises a low-illumination image and a normal-illumination image of the same scene, and generating, according to each training sample, a group of a short-exposure image, a long-exposure image and a real-illumination image, which correspond to each other, so as to obtain a synthetic data set S; 2) training a low-illumination enhancement model by using the synthetic data set S, wherein the low-illumination enhancement model comprises M-1 feature alignment modules and M-1 brightening modules; and 3) inputting a short-exposure image to be brightened and a corresponding blurred long-exposure image into the trained low-illumination enhancement model, so as to obtain a corresponding low-illumination enhanced image. The present invention can significantly improve the performance of low-illumination image enhancement.
The present invention relates to a trifunctional compound, comprising at least one covalent warhead capable of forming a reversible or irreversible covalent linkage with a protein or tissue. The present invention further relates to a pharmaceutical composition and kit comprising the trifunctional compound, and use of the trifunctional compound in the diagnosis or treatment of diseases.
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61P 25/00 - Drugs for disorders of the nervous system
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
37.
FERROELECTRIC MEMORY AND FERROELECTRIC CAPACITOR THEREOF AND PREPARATION METHOD THEREFOR
BEIJING SUPERSTRING ACADEMY OF MEMORY TECHNOLOGY (China)
PEKING UNIVERSITY (China)
Inventor
Huang, Qianqian
Yang, Mengxuan
Huang, Ru
Abstract
A ferroelectric memory and a ferroelectric capacitor thereof and a preparation method therefor, belonging to the field of semiconductor storage devices. A layer of antiferroelectric dielectric layer is introduced before a ferroelectric dielectric layer in the ferroelectric capacitor grows,. When the antiferroelectric layer is used as a seed layer, a crystallization template is provided for the ferroelectric dielectric layer, so that the proportion of a ferroelectric phase is increased, the residual polarization intensity is improved, and the storage window is further improved. In addition, when the antiferroelectric layer is used as an interface layer, said layer has lower surface energy and a more stable electrode contact interface than other phases, interface defects and leakage currents are reduced, the oxygen vacancy concentration is reduced, generation of oxygen vacancies during an electrical circulation process is inhibited, the durability is improved, and the reliability of the memory is improved. The present invention facilitates the low-power-consumption, high-performance and high-reliability use of the ferroelectric random access memory.
The present application relates to the technical field of semiconductors, and provides a Schottky transistor, a diode, and a cold source semiconductor structure and a preparation method therefor. The cold source semiconductor structure comprises a heavily doped P-type region, a metal region, and a lightly doped N-type region. The metal region is connected between the heavily doped P-type region and the lightly doped N-type region, and the metal region is platinum silicide, and the end of the lightly doped N-type region adjacent to the metal region is doped with sulfide ions. The present application can lower a Schottky barrier in contact with a semiconductor structure, thereby improving an on-state current.
H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
H01L 21/336 - Field-effect transistors with an insulated gate
H01L 21/329 - Multistep processes for the manufacture of devices of the bipolar type, e.g. diodes, transistors, thyristors the devices comprising one or two electrodes, e.g. diodes
39.
ENCODING METHOD, DECODING METHOD, AND ELECTRONIC DEVICE
Provided in the embodiments of the present application are an encoding method, a decoding method, and an electronic device. The encoding method comprises: firstly, acquiring data to be encoded; then, performing feature transformation on said data according to a preset network, so as to obtain a latent feature corresponding to said data; next, performing wavelet decomposition on the latent feature, so as to obtain N wavelet coefficient groups, wherein N is an integer greater than 1; and then respectively performing vector quantization on the N wavelet coefficient groups, so as to obtain a code stream of said data. Compared with directly performing vector quantization on a latent feature, vector quantization is performed after the latent feature is decomposed into a plurality of wavelet coefficient groups of smaller size, such that the size of a codebook which is used for vector quantization is smaller under the same code rate, and thus the storage space which is occupied by the codebook can be reduced.
H04N 19/63 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using transform coding using sub-band based transform, e.g. wavelets
40.
CELL DIFFERENTIATION BASED ON MACHINE LEARNING USING DYNAMIC CELL IMAGES
The present invention relates to the field of biomedicine, in particular to a cell differentiation method based on machine learning using dynamic cell images, and more particularly to a method and apparatus for obtaining differentiated target cells (such as cardiomyocytes) from starting cells such as pluripotent stem cells (such as induced pluripotent stem cells) under the assistance of machine learning using dynamic cell images.
Provided in the embodiments of the present application are a transaction processing method and apparatus, and an electronic device. The method comprises: detecting whether target data, which a first transaction targets, is occupied by a second transaction, wherein the first transaction comprises an operation for processing the target data, and the second transaction is another transaction, which is in parallel with the first transaction; and in response to the target data being occupied by the second transaction and according to the type of occupation of the target data by the second transaction and the type of the operation that is comprised in the first transaction and is used for processing the target data, executing the operation comprised in the first transaction, so as to process the target data. By means of the embodiments of the present application, system calling is not required to control parallel first and second transactions with regard to a scenario in which the same target data is processed, thereby avoiding frequent involvement in a kernel mode of an operating system, improving the transaction processing efficiency, and increasing the throughput of the system.
Provided herein pertains to the biomedical field, and particularly relates to a method for activating N-oxide prodrugs with radiation, and a method of treating or suppressing a cancer, reducing its severity, lowering its risk or inhibiting its metastasis in an individual. The method comprises administering to the individual a therapeutically effective amount of an N-oxide prodrug, and radiating the individual with a therapeutically effective amount of radiotherapy.
Provided are a diazo compound, a preparation method therefor, and a use thereof. The diazo compound has a structure as shown in formula (I), wherein R1 represents H, an alkyl, a halogen, an alkoxy or an alkylamino; and R2 represents an aryl. On the basis of using the diazo compound as a derivatization reagent, after derivatization treatment, the mass spectrometry response of a small molecule carboxylic acid can be clearly enhanced, the detection sensitivity is improved, and therefore the detection accuracy is improved. Moreover, the derivatized small molecule carboxylic acid does not need to be provided with a special chromatographic column and does not need to be provided with a special mobile phase, the optimal separation effect can be achieved in a shorter time with a lower cost, high-throughput sample detection is better facilitated, and the detection accuracy is improved. In particular, on the basis of using the diazo compound as a derivatization reagent, the beneficial effects of in-situ derivative cell samples can be effectively achieved.
C07D 215/14 - Radicals substituted by oxygen atoms
C07C 245/18 - Diazo compounds, i.e. compounds having the free valencies of N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
Provided in the present disclosure is an SRAM storage and computing integrated chip based on capacitive coupling. The SRAM storage and computing integrated chip comprises an input module, a bitwise multiplication module, a capacitance attenuation module and an output module, wherein the input module is used to receive input data; the bitwise multiplication module is used to realize a multiplication operation on the input data and storage data, so as to obtain a multiplication operation result; and the capacitance attenuation module is used to layer the structure of a capacitance attenuator to realize layered accumulation of multiplication operation results. The structure is simpler, and the calculation time is also shorter such that a number accumulation result can be quickly obtained, thereby improving the energy efficiency of a multiplication accumulation operation, and increasing the computation throughput.
A double-stranded DNA deaminase mutant for constructing a mitochondrial base editor, a base editor for mitochondrial DNA base editing, and a method for base editing.
Provided in the embodiments of the present disclosure are a Linux kernel optimization processing method and apparatus, and a storage medium and an electronic apparatus. The method comprises: generating a fine optimization configuration table according to a user configuration table; performing targeted interpolation on a kernel source code, and running a target program, so as to obtain kernel feedback information; and performing optimization processing on the kernel source code according to the fine optimization configuration table and the kernel feedback information, so as to obtain an optimized kernel. Therefore, the problems in the related art of the granularity of an object on which kernel source code optimization acts being relatively large, it being impossible to fully exert a compilation optimization capability of a modern compiler, and it being impossible to flexibly control the range of compilation optimization can be solved; and an optimization process is automatically completed by using a compiler plug-in, such that an action range of Linux kernel feedback type optimization can be freely controlled, and the running performance of an application program is additionally improved without modifying the application program.
The present disclosure provides a position prediction method and apparatus, an electronic device, and a storage medium. The method comprises: determining coordinates of three trajectory points at equal time intervals in a historical trajectory; activating a first spiking neuron in a position prediction model on the basis of the coordinates of the three trajectory points, to obtain spikes corresponding to each of the three trajectory points, output by the activated first spiking neuron; on the basis of the spikes corresponding to each of the three trajectory points and a connection strength between the first spiking neuron and a second spiking neuron in the position prediction model, activating the second spiking neuron, to obtain a position prediction result outputted by the activated second spiking neuron. In the present method, a position prediction model constructed using a spiking neural network is used, and the model activates a spiking neuron and outputs a position prediction result according to coordinate information of three input trajectory points, thereby reducing calculation complexity, shortening a delay from input to output, improving the effect of the prediction result, and further improving a real-time response effect.
A compound of a GPR132 regulator, a pharmaceutically acceptable salt or ester, a prodrug, a stereoisomer, a hydrate, a solvate, a crystal form, or a metabolite form thereof, as well as a preparation method therefor and medicinal use thereof.
C07D 307/85 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 333/70 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
NINGBO INSTITUTE OF MARINE MEDICINE, PEKING UNIVERSITY (China)
PEKING UNIVERSITY (China)
Inventor
Zhou, Demin
Ji, Dezhong
Sun, Jiaqi
Zhang, Bo
Abstract
A combination of PEGylated IL-2 variants with different receptor biases is provided. The combination inhibits the amplification of immunosuppressive lymphocytes and reduces the terminal differentiation and depletion of effector lymphocytes by means of a synergistic effect, possessing a synergistic anti-tumor effect, so that the combination can be used for enhancing immune response and treating proliferative diseases such as tumors. In addition, the combination can also be used for in vitro culture of immune cells in adoptive cell immunotherapy, reducing the aging and depletion of immune cells, thereby leading the fate of the immune cells in the adoptive cell immunotherapy to long-term immunity. Also provided are a combined therapy for enhancing immune response and treating proliferative diseases such as tumors, and an in vitro method for preparing or culturing immune cells for adoptive cell therapy.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
The present invention relates to a GPCR regulator and use thereof, and particularly provides a compound represented by formula (I), or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a pharmaceutically acceptable ester of the compound.
C07D 307/79 - Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 333/62 - Benzo [b] thiophenes; Hydrogenated benzo [b] thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 209/10 - Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
Disclosed are an FXR regulator and use thereof, and specifically disclosed are a compound represented by formula I, or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a pharmaceutically acceptable ester of the compound.
C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 307/82 - Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07C 309/76 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
An automatic design method for a storage-calculation module interconnection circuit of a hardware accelerator. An expected behavior of data in a storage module of a hardware accelerator is analyzed by means of space-time transformation (STT), data reuse in the storage module is calculated and classified, an optimal storage-calculation module interconnection circuit mode is further automatically selected, and multicast interconnection or rotary interconnection is achieved. The present method can effectively improve the interconnection efficiency of a hardware storage-calculation module, and reduce the consumption of storage resources.
G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
Disclosed in the present invention is a gradient field-based point cloud repair method. Firstly, a distributed global gradient field is estimated from an input degenerated point cloud; then gradient ascent is carried out by using the estimated gradient field, and points are converged to a potential surface, so as to complete point cloud repair.
The present disclosure provides a method of preventing or treating virus infection by inhibiting Lipin1, wherein the virus infection is caused by a positive strand RNA virus. Also provided are use of Lipin1 inhibitor in treating positive strand RNA virus infection, as well as a combined use of the Lipin1 inhibitor and an additional antiviral treatment.
A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
A method for growing a large-area high-performance hole conductive tungsten diselenide single crystal on a silicon-based insulating layer. A molten salt reacts with a tungsten source to generate an intermediate product having lower melting point and higher vapor pressure, such that a tungsten diselenide single crystal is more easily grown on a silicon oxide or high-dielectric-constant insulating layer on a silicon substrate on the basis of the principle of chemical vapor deposition, and meanwhile, large-area growth of tungsten diselenide is achieved by changing a substrate placing mode. The method may effectively achieve layer number controlled growth of large-area multi-layer tungsten diselenide single crystals, thus a silicon-based compatible high-mobility hole conductive two-dimensional material can be obtained, the operation is easy, transfer is not needed, and the material quality is higher.
Provided are an amino acid polymer, and a preparation method therefor and the use thereof as a natural gas hydrate kinetic inhibitor. The provided amino acid polymer structure contains an isopropyl side chain group. The isopropyl has relatively strong hydrophobicity, whereby the hydrophobic isopropyl can solidify the structure of water molecules, such that water molecules around the isopropyl can be bound, and the cage-shaped water structure of a natural gas hydrate is not easy to form, thereby inhibiting the nucleation of the natural gas hydrate. Therefore, the nucleation of the natural gas hydrate can be effectively delayed and the generation rate of the natural gas hydrate can be reduced under the condition of a low dosage concentration and a high supercooling degree environment, and the present invention has the advantages of a good inhibition effect, a small dosage, a low cost, wide applicability, etc.
The present invention belongs to the technical field of chemical production, and particularly relates to an amino acid polymer, and a preparation method therefor and the use thereof as a natural gas hydrate kinetic inhibitor. An S=O bond on a side chain of the provided amino acid polymer can form a hydrogen bond with water molecules, such that water molecules around the S=O bond are interfered, and the cage-shaped water structure of a natural gas hydrate is not easy to form, thereby inhibiting the nucleation of the natural gas hydrate. In addition, the main chain of the polymerization unit as shown in formula 1 contains an amide group, and N and O atoms in the amide group can be adsorbed on the surface of the natural gas hydrate by means of hydrogen bonds, such that further growth of natural gas hydrate crystals is inhibited. Therefore, the provided amino acid polymer can effectively delay the nucleation of the natural gas hydrate and reduce the generation rate of the natural gas hydrate under the condition of a low dosage concentration and a high supercooling degree environment, and has the advantages of a good inhibition effect, a small dosage, a low cost, wide applicability, etc.
A method for highly orienting platinum on the basis of vertical heteroepitaxy of single crystal tungsten diselenide, comprising: using single crystal tungsten diselenide as an epitaxial substrate; depositing a polycrystalline platinum thin film on the epitaxy of the epitaxial substrate; and then, longitudinally inducing, by means of oxygen annealing, platinum to form a highly oriented platinum thin film along tungsten diselenide, wherein a gap between the platinum and the tungsten diselenide is smaller than the Van der Waals distance, so that a better two-dimensional material is formed to contact a metal, thereby reducing the Schottky barrier height for a metal-semiconductor contact. According to the method, the problem that a highly oriented metal thin film is difficult to prepare, limited in size and high in costs is solved. A tungsten diselenide field effect transistor is a PMOS, and achieves high-quality contact between a tungsten diselenide semiconductor and a metal by means of the method, thereby reducing contact resistance, being complementary to an NMOS field effect transistor, and improving the performance of a nanosheet CMOS device.
The present invention relates to a use of a compound and an extract derived from natural fungus Antrodia camphorata in the preparation of an FGF21 agonist and/or an RDH10 agonist.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 9/00 - Drugs for disorders of the cardiovascular system
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07J 17/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta[a]hydrophenanthrene skeleton
60.
INDUCED TOTIPOTENT POTENTIAL STEM CELLS, METHODS OF MAKING AND USING
Factors for deriving totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos are provided. A cell culture media composition for deriving cell totipotency in vitro of isolated cells and an isolated chemically induced totipotent potential stem cells(ciTPSCs) obtained by using the composition are provided. The composition comprises chemical derivers of totipotency (CDTs) from each of the following groups (l) an HDAC inhibitor, (2) a Dot1L inhibitor, (3) an RARy agonist, and (4) optionally, a GSK inhibitor, in amounts effective to induce an untreated cell into a totipotent potential stem (TPS) cell. The ciTPSCs can be used in, e.g., cell therapy and tissue engineering.
A charging base station network system, comprising: a plurality of unmanned aerial vehicle base stations and a central command center (U0); the unmanned aerial vehicle base stations are distributed in a preset area according to a preset distance, the preset distance being the distance between any two adjacent unmanned aerial vehicle base stations; and the central command center (U0) and the unmanned aerial vehicle base stations perform signal communication. Each unmanned aerial vehicle base station comprises: a power generation and storage platform, an unmanned aerial vehicle group (U3), a charging platform (U5), and a base station console (U6). The power generation and storage platforms are configured to supply power to the unmanned aerial vehicle base stations, the power supply amount of the power generation and storage platforms being regulated on the basis of the power consumption requirements of the charging base station network system; the base station consoles (U6) transmit signals to and receive signals from the central command center (U0) and the unmanned aerial vehicle base stations, and acquire information such as the location, environment and working conditions of the unmanned aerial vehicle base stations; each unmanned aerial vehicle group (U3) comprises at least two unmanned aerial vehicles which leave the unmanned aerial vehicle base station to execute a flight task; and the charging platforms (U5) are electrically connected to the unmanned aerial vehicles to charge the unmanned aerial vehicles. The charging base station network system solves the problem of on-site charging of unmanned aerial vehicles which are sent to an area far away from a populated area to carry out investigation work.
The present invention relates to a polyethylene glycol modified zwitterionic fluorescent probe. A core luminous group of the fluorescent probe of the present invention is a heptamethine chain which is connected to a phenoxy bridge and is of a rigid ring structure in the center; two ends of the heptamethine chain are two sulfonic acid indole groups; two polyethylene glycol chains are connected to the indole groups; a tumor targeting ligand is connected to the luminous group by means of a polyethylene glycol chain and a basic amino acid linking group; and the probe of the present invention can be connected to polypeptide, small molecules, and an antibody which have a tumor targeting function, so that tumor targeting near-infrared fluorescence imaging is realized. The probe of the present invention is simple in synthesis method, high in fluorescence quantum yield, low in non-specific fluorescence signal, and high in tumor imaging signal-to-noise ratio, and therefore, the probe has very good druggability and is very suitable for industrial production and clinical popularization.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 9/19 - Particulate form, e.g. powders lyophilised
Disclosed are a neural unit circuit, a spiking neural network and an intelligent Internet of Things chip. The neural unit circuit comprises: a dendritic circuit, a synaptic circuit comprising a membrane potential capacitor, a cell body circuit, and a time planning module. According to an input pulse signal or an output pulse signal of a neuron cell body circuit of a previous layer, the dendritic circuit generates a reset signal and a calculation signal that does not overlap with the reset signal. The synaptic circuit stores a weight, and performs a potential accumulation operation of the membrane potential capacitor according to the stored weight and an output of the dendritic circuit. The cell body circuit compares the membrane potential of the membrane potential capacitor with a threshold voltage to determine whether to output a pulse signal. The time planning module is used for generating a time sequence according to the input pulse signal or an enable signal outputted by a neural unit of the previous layer, so that the threshold voltage is stored in a threshold capacitor before a cell body performs a comparison operation, and the cell body is triggered to perform the comparison operation. According to the present invention, a final event driving circuit having a system level and a module level to a circuit level is achieved.
INSTITUTE OF BIOPHYSICS , CHINESE ACADEMY OF SCIENCES (China)
PEKING UNIVERSITY (China)
Inventor
Shi, Jiyun
Wang, Fan
Yang, Guangjie
Abstract
224211 is -C(O)-L-NH-; BFC is a bifunctional chelating agent. A radiopharmaceutical is formed by the radionuclide-labeled precursor compound, and the pharmaceutical can be used as a diagnostic imaging agent or a radioactive targeted therapeutic agent for FAP-positive tumors or FAP-positive fibrotic diseases (such as pulmonary fibrosis and liver fibrosis).
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
Provided are methods of treating a disease or condition by administering a circular RNA (circRNA) encoding a therapeutic polyeptide (e.g., an antigenic polypeptide, a functional protein, a receptor protein, or a targeting protein (e.g., antibody)), wherein the circRNA is naked; and pharmaceutical composition (s) comprising the circRNA (s) as disclosed herein.
The present application provides an early screening device for acquired resistance to immunotherapy and use thereof. The early screening device for acquired resistance to immunotherapy comprises a sequencing module, a screening module, a cluster analysis module, a monitoring module, and an analysis module. Through a comprehensive judgment based on the combination of the real-time monitoring of proportion change in cancer cell killer CD8 T cell clones in the peripheral blood with the proportion change of inexhaustible precursor T cells in the cancer cell killer CD8 T cell clones in biopsy samples, the present application can achieve very early screening of acquired resistance to immunotherapy.
C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
67.
INSTRUCTION PARSING METHOD AND APPARATUS, AND ELECTRONIC DEVICE
PEKING UNIVERSITY CHONGQING RESEARCH INSTITUTE OF BIG DATA (China)
Inventor
Li, Ruo
Lu, Tiao
Abstract
Disclosed in the present application are an instruction parsing method and apparatus, and an electronic device. The method comprises: receiving a target instruction and a parameter processor set, wherein the target instruction comprises a target instruction parameter vector, composition elements of the target instruction parameter vector are target instruction parameters, the parameter processor set comprises at least one parameter processor, and the parameter processor is composed of a preset command parameter vector to be matched and a first preset anonymous function; determining a target parameter processor from among parameter processors that match the target instruction parameter in the target instruction parameter vector, and processing the target instruction parameter by using the target parameter processor, so as to obtain a processing result; and determining, according to the processing result, a processing command corresponding to the target instruction, and executing the processing command.
PEKING UNIVERSITY CHONGQING RESEARCH INSTITUTE OF BIG DATA (China)
Inventor
Li, Ruo
Lu, Tiao
Abstract
Disclosed in the present application are a method and apparatus for parsing a programming language, and a non-volatile storage medium. The method comprises: identifying a source code as a character stream, and parsing the character stream into a lexical unit list, wherein the lexical unit list comprises a plurality of lexical units; dividing the plurality of lexical units into first-type lexical units and second-type lexical units, wherein each first-type lexical unit is a lexical unit that comprises an ambiguous symbol, and each second-type lexical unit is a lexical unit that comprises no ambiguous symbol; converting the first-type lexical units into the second-type lexical units; and parsing second-type lexical units which are obtained by means of converting the first-type lexical units, and second-type lexical units which are obtained by means of classifying the plurality of lexical units.
A complex action recognition method and apparatus based on a learnable Markov logic network. The method comprises: automatically learning, from training data and by using a policy network, a logic rule set which corresponds to each action; segmenting a video to be tested into a plurality of video clips, and calculating a confidence score for a triple in each video clip; inputting, into an improved Markov logic network, the logic rule set and the confidence scores of all the triples in one video clip, so as to obtain the probability of occurrence of each action in the video clip; and acquiring an action recognition result of said video according to the probability of occurrence. The method has significant interpretability, good compatibility and high efficiency, such that the category of an action can be recognized, and the position of the action in a video clip can also be positioned.
The present application belongs to the technical field of communication and provides a method for flow statistics, a device, and a system. In a solution provided by the present application, a network device obtains a target flow index and a target address index according to a target flow identifier of a data flow to which a target message belongs; then the network device updates, according to the target flow index, a packet count value and/or a flow index in a first storage unit among a plurality of storage units indicated by the target address index (104), and performs statistics on traffic of a data flow to which the target packet belongs on the basis of the updated packet count value in the first storage unit (105). In the described process for traffic statistics, the network device does not need to report a sampled packet to a control device, and thereby the efficiency for flow statistics is effectively improved, and same does not take up storage space of the control device. Furthermore, the target flow index can be obtained by means of a mapping function processing the target flow identifier, and therefore storage space occupied by a flow index can be reduced.
Provided are circular RNAs (circRNAs) encoding an antigenic polypeptide of a SARS-CoV-2 variant. Provided are circRNA vaccines against a SARS-CoV-2 variant, such as a Delta or Omicron variant. The circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike (S) protein or a fragment thereof of a SRAS-CoV-2 variant. Also provided are methods of treating or preventing a SARS-CoV-2 infection using the circRNAs or compositions thereof.
Provided are circular RNAs (circRNAs) encoding an antigenic polyeptide of a SARS-CoV-2 variant. Provided are circRNA vaccines against a SARS-CoV-2 variant, such as a Delta or Omicron variant. The circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike (S) protein or a fragment thereof of a SARS-CoV-2 variant. Also provided are methods of treating or preventing a SARS-CoV-2 infection using the circRNAs or compositions thereof.
The present application provides a device for predicting the treatment effect of immune checkpoint blockade therapy and an application thereof. The device for predicting the treatment effect of immune checkpoint blockade therapy comprises: a detection module used for detecting CD3 and CXCL13 double-positive cells and/or CD8 and CXCL13 double-positive cells in a sample, and calculating the proportion of the CD3 and CXCL13 double-positive cells in CD3T cells and/or the proportion of the CD8 and CXCL13 double-positive cells in CD8T cells; and an analysis module used for performing determination according to the calculation result. According to the present application, by selecting the proportion of the CD3 and CXCL13 double-positive cells in the CD3T cells and/or the proportion of the CD8 and CXCL13 double-positive cells in the CD8T cells as determination standards, the response of the sample to immune checkpoint blockade therapy is predicted, the result is accurate, and applicability is high.
A cold-source Schottky transistor and a preparation process therefor. The cold-source Schottky transistor comprises a substrate (101), a source region, a drain region (4), a channel region (3), a source electrode, a drain electrode and a gate electrode, wherein the source region is arranged on the substrate (101), the source region comprises a first source region (1) and a metal region (2) connected to the first source region (1), and the first source region (1) is a heavily doped region; the drain region (4) is arranged on the substrate (101), the drain region (4) is a heavily doped region, and the doping type of the drain region (4) is opposite to that of the first source region (1); the channel region (3) is arranged on the substrate (101), the channel region (3) is located between the metal region (2) and the drain region (4), and a gate electrode dielectric (5) is arranged on the upper side and/or the lower side of the channel region (3); the source electrode is arranged on the source region; the drain electrode is arranged on the drain region (4); and the gate electrode is arranged on the gate electrode dielectric (5).
The present application belongs to the technical field of graph databases. Disclosed are a data query method and apparatus, and a device and a storage medium. The method comprises: receiving a data query instruction, which is sent by a data query application program, wherein the data query instruction carries a data query statement; on the basis of the structure of the data query statement, establishing a first query tree corresponding to the data query statement; performing simplification processing on the first query tree on the basis of the type of each node in the first query tree, so as to obtain a second query tree; on the basis of a preset execution sequence, sequentially executing, in a graph database, query operations corresponding to respective nodes in the second query tree, so as to obtain a data query result; and returning the data query result to the data query application program. By means of the present application, the data query efficiency in a graph database can be improved.
A data independent acquisition (DIA)-based quantitative chemical proteomics target screening method, comprising: carrying out covalent modifications on specific active amino acids in a proteome by employing an active molecular probe; and by means of a DIA-based quantitative omics method, performing quantitative analysis on sites subjected to probe covalent modification to obtain candidate targets. According to the DIA-based quantitative chemical proteomics target screening method, DIA-based quantitative omics technology is applied to activity-based protein profiling (ABPP) to form DIA-ABPP, so that high coverage, high reproducibility and high-precision target screening may be achieved, and corresponding technical support is provided for subsequent drug development.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
77.
INDIUM TIN OXIDE VERTICAL GATE-ALL-AROUND FIELD EFFECT TRANSISTOR AND PREPARATION METHOD THEREFOR
BEIJING SUPERSTRING ACADEMY OF MEMORY TECHNOLOGY (China)
PEKING UNIVERSITY (China)
Inventor
Wu, Yanqing
Hu, Qianlan
Xiong, Xiong
Tong, Anyu
Abstract
An indium tin oxide vertical gate-all-around field effect transistor, having a vertical gate-all-around structure and comprising an insulating substrate, on which a drain electrode, an indium tin oxide channel layer having a large depth-to-width ratio, and a source electrode are sequentially stacked from bottom to top, wherein the indium tin oxide channel layer is wrapped by a high-k gate dielectric layer and a gate electrode in a surrounding manner to form a gate-all-around structure. The indium tin oxide channel is surrounded by a surrounding gate, so that a gate control capability is enhanced, short channel effects can be better suppressed, a process node is further promoted, and compared with a planar surrounding gate, limitations on the length and a source-drain contact area are less strict, an overall process thermal budget is within 300°C, and three-dimensional stacking can be performed, thereby effectively improving the integration density.
H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , , or
H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
H01L 21/34 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having at least one potential-jump barrier or surface barrier, e.g. PN junction, depletion layer, carrier concentration layer the devices having semiconductor bodies not provided for in groups , , and with or without impurities, e.g. doping materials
The present application provides methods for producing circular RNAs (circRNAs) from a DNA construct encoding a linear RNA precursor, wherein the linear RNA precursor comprises from the 5'-end to the 3' end: a 3' catalytic Group I intron fragment, a 3' exon sequence, an effector RNA sequence, a 5' exon sequence, and a 5' catalytic Group I intron fragment, wherein the method comprises an in vitro single-pot reaction. In some embodiments, the single-pot reaction does not comprise supplementing the reagent composition with GTP, a divalent metal ion such as Mg2+, or DNase I prior to circularization of a linear RNA precursor.
C12N 15/11 - DNA or RNA fragments; Modified forms thereof
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Provided is a method for cell-cell interaction labeling and detection of antigen-specific T cells. Further provided is a method comprising: contacting a first cell with a second cell in the presence of a detectable label, wherein said second cell is bound with a sensitizing molecule, inducing binding of said detectable label to said first cell when said first cell is within an effective proximity range of said sensitizing molecule.
BEIJING SUPERSTRING ACADEMY OF MEMORY TECHNOLOGY (China)
PEKING UNIVERSITY (China)
Inventor
Wu, Yanqing
Xiong, Xiong
Hu, Qianlan
Tong, Anyu
Abstract
A fully transparent thin-film transistor based on indium tin oxide (ITO). The fully transparent thin-film transistor comprises a substrate, a buffer layer, a gate electrode, a gate dielectric layer, a channel layer and source and drain electrodes, wherein the gate electrode and the source and drain electrodes are made of metallic ITO, and the channel layer is made of semiconducting ITO. The semiconducting and metallic properties of ITO can be achieved by means of adjusting growth thickness and oxygen partial pressure in magnetron sputtering. Such a field-effect transistor device based on an ITO electrode can achieve better transmission of light. In addition, compared with other conventional oxide semiconductor devices, the design can significantly reduce the use of metallic materials, thereby further reducing the preparation difficulty and cost; and by using high mobility semiconductor channel ITO, the device can provide a superior driving capability compared with other conventional oxide semiconductors.
Disclosed is a method for enhancing the activity of a photosensitizer by means of a magnetic field. In the method, under an illumination condition, the photosensitizer is placed in a magnetic field, which can improve the cytotoxicity of the photosensitizer to tumor cells and improve the activity of the photosensitizer. Then the apoptosis of cancer cells or an inhibitory effect on tumor issue is further enhanced by means of a photodynamic therapy method, which is helpful to improving an effect of photodynamic therapy.
The present disclosure relates to the technical field of endoscopes, and provides an endoscope having a movable front end. The endoscope comprises a main tube, a camera portion, an elastic deformation portion and a driving portion. A through main tube cavity is formed in the main tube, and the main tube cavity is used for at least arranging a working appliance in a penetrating mode. The elastic deformation portion is connected to the camera portion and is located at the outlet end of the main tube. The elastic deformation portion enables the camera portion to correspond to the outlet of the main tube cavity. The driving portion allows the position of the camera portion to be switched between a first position and a second position. In the first position, the camera portion does not increase the size of the front end of the endoscope, and can be more easily placed in the human body cavity. The driving portion acts on the camera portion and/or the elastic deformation portion, so that a part or all of the camera portion avoids the outlet of the main tube cavity, and at this moment the outlet of the main tube cavity is unblocked, and the main tube cavity can allow a large-size working appliance to pass through. By means of the present disclosure, the endoscope can be conveniently placed in the human body cavity, and the size of the working appliance which can pass through the main pipe cavity is increased.
INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY, CHINESE ACADEMY OF SCIENCES (China)
Inventor
Lei, Xiaoguang
Zhou, Jian-Min
Wang, Haijun
Miao, Pei
Wang, Wei
Abstract
The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by gram-negative bacteria in a host species, including but not limited to, plants and animals. The present invention further relates to compositions that inhibit pathogenesis of gram-negative bacteria without killing the bacteria. Methods relating to preventing and/or treating infection of a host species by bacterial pathogens are also provided herein.
C07C 233/02 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
C07D 307/26 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
C07C 231/00 - Preparation of carboxylic acid amides
A01N 43/02 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
CHINA MOBILE COMMUNICATIONS GROUP CO., LTD. (China)
PEKING UNIVERSITY (China)
Inventor
Li, Lin
Gu, Ming
Zhou, Bing
Xu, Song
Feng, Yanan
Chen, Min
Cai, Weiyong
Ma, Siwei
Yin, Qian
Wang, Shanshe
Abstract
A point cloud processing method and apparatus and an electronic device, which relate to the technical field of data processing and solve the problem of the low efficiency of existing point cloud encoding. The method comprises: acquiring radar point cloud data; on the basis of the Z-axis coordinate data of the radar point cloud data, generating a Z-axis distribution histogram of the radar point cloud data, wherein the Z-axis distribution histogram represents the relationship between the Z-axis coordinate interval and the point cloud number; according to the Z-axis distribution histogram, determining a point cloud number range parameter used for dividing a ground point cloud; and, according to the point cloud number range parameter, dividing out a ground point cloud strip from the radar point cloud data. The method can ensure that ground point cloud data is rationally divided out from radar point cloud data, thereby improving the point cloud encoding efficiency.
CHINA MOBILE COMMUNICATIONS GROUP CO., LTD. (China)
PEKING UNIVERSITY (China)
Inventor
Li, Lin
Gu, Ming
Zhou, Bing
Fu, Rong
Feng, Yanan
Wang, Fei
Xing, Gang
Li, Chenshuai
Liu, Jianlong
Ma, Siwei
Yin, Qian
Wang, Shanshe
Abstract
The present application discloses a point cloud entropy coding method and apparatus, a point cloud entropy decoding method and apparatus, and a device and a computer-readable storage medium, and relates to the technical field of point cloud coding and decoding, so as to improve the point cloud compression performance. The point cloud entropy coding method comprises: acquiring transform coefficients of a point cloud frame to be coded; according to the transform coefficients, determining a target coding mode; and performing entropy coding on said point cloud frame by using the target coding mode, wherein the transform coefficients comprise direct-current (DC) coefficients and alternating-current (AC) coefficients, and at least some of the DC coefficients and/or the AC coefficients are separately arranged according to a color channel. The present application can improve the point cloud compression performance.
H04N 19/88 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using pre-processing or post-processing specially adapted for video compression involving rearrangement of data among different coding units, e.g. shuffling, interleaving, scrambling or permutation of pixel data or permutation of transform coefficient data among different blocks
H04N 19/64 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using transform coding using sub-band based transform, e.g. wavelets characterised by ordering of coefficients or of bits for transmission
86.
EMBEDDED SEMICONDUCTOR RANDOM ACCESS MEMORY STRUCTURE AND CONTROL METHOD THEREFOR
An embedded semiconductor random access memory structure, comprising: a hafnium-based ferroelectric memory unit, which is used for storing information; and a tunneling field-effect transistor, which is connected to the memory unit, wherein the tunneling field-effect transistor is used for controlling the hafnium-based ferroelectric memory unit to perform a write operation and a read operation. A plurality of memory structures constitute a semiconductor memory array, and a control method therefor comprises the steps of writing 0, writing 1, reading and rewriting. According to the present invention, by utilizing the one-way conduction characteristic and the extremely low leakage current characteristic of a tunneling field-effect transistor, an operation voltage and the power consumption of a memory array can be reduced, and the integration density of memories can be increased. The present invention is suitable for manufacturing a semiconductor memory chip, and the control method and circuit in the present invention are also relatively simple.
H01L 27/24 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including solid state components for rectifying, amplifying, or switching without a potential-jump barrier or surface barrier
87.
GRANZYME B TARGETING COMPLEX, RADIOPHARMACEUTICAL, PREPARATION METHOD THEREFOR, AND USE THEREOF
The present invention belongs to the field of nuclear medicine, and relates to a granzyme B targeting complex, a radiopharmaceutical, a preparation method therefor, and a use thereof. The structure of the granzyme B targeting complex is shown in formula (I), wherein R is any one among a bifunctional chelating group or derivative thereof for radionuclide labeling. The granzyme B targeting complex provided by the present invention can undergo radionuclide labeling to prepare a granzyme B targeting radiopharmaceutical. The provided granzyme B targeting radiopharmaceutical is simple to prepare. Compared with other granzyme B targeting drugs, the described complex has better pharmacokinetic properties and metabolic stability in vivo. The expression level of granzyme B in vivo can be monitored non-invasively by means of nuclear medicine imaging.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
The present disclosure provides a carborane-phospholipid conjugate, in which carboranyl is introduced at the end of the arm of a phospholipid. The present disclosure also provides a liposome composition comprising the carborane-phospholipid conjugate, and a use of the composition in delivering at least one therapeutic agent and/or at least one diagnostic agent.
A magnetization reversal device based on orbital transfer torque and an implementation method therefor. A direct-current write current is introduced by means of source and drain electrodes, and polarization of an out-of-plane orbital magnetic moment is generated, thereby generating an out-of-plane anti-damping moment effect; under the out-of-plane anti-damping moment effect, magnetization reversal of a perpendicular magnetic anisotropy free ferromagnetic layer can be achieved without additional magnetic field assistance, which is referred to as orbital transfer torque; after withdrawing the write current, the perpendicular magnetic anisotropy free ferromagnetic layer maintains the changed magnetization state, thus being non-volatile; a direct-current write current is introduced by means of source and drain electrodes, and the Hall resistance of a heterojunction is obtained by means of measuring the electrodes, thereby reflecting the magnetization state of the perpendicular magnetic anisotropy free ferromagnetic layer; by changing the direction of the write current, reverse orbital transfer torque is achieved, thereby enabling magnetization inverse reversal of the perpendicular magnetic anisotropy free ferromagnetic layer. Less critical current is required for orbital transfer torque to achieve magnetization reversal, thus the power consumption of the device can be significantly reduced.
H01L 43/04 - Devices using galvano-magnetic or similar magnetic effects; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details of Hall-effect devices
H01L 43/14 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof for Hall-effect devices
G11B 5/127 - Structure or manufacture of heads, e.g. inductive
A method for infiltration growth of a carbon film, comprising the following steps: S1, providing a foil, wherein the foil is selected from a nickel foil or a copper-nickel alloy foil and has a first surface and a second surface; and S2, using the foil as a substrate and placing same on a solid carbon source, wherein the first surface of the foil is close to the solid carbon source, and the second surface of the foil is away from the solid carbon source, and then heating the foil and the solid carbon source, so that a carbon film is formed by infiltration growth on the second surface of the foil.
tttt and the binary image P' to generate a compensation result of each color surface; and obtaining a compensation result for printing the original image on the basis of the compensation result of each color surface.
The present invention provides a partial differential equation solving method based on a non-volatile memory array, comprising converting a partial differential equation to be solved into a corresponding iteration relational expression; selecting from a iteration coefficient matrix a sub-matrix unit that can be multiplexed, and storing the sub-matrix unit in a non-volatile memory array; extracting an input vector from an iteration solution vector, inputting the input vector into the non-volatile memory array, updating a part of the iteration solution vector after adding a corresponding part of a constant vector to an obtained output vector, extracting an input vector from the updated iteration solution vector again, and inputting the input vector into the non-volatile memory array until all elements of the iteration solution vector are updated, so as to obtain an iteration solution vector participating in the next iteration operation; and ending an iteration operation when a preset number of iterations is reached or an error is smaller than a preset range.
Provided in the present disclosure are a random number generator and a random number generation method. The random number generator comprises: a random number generation circuit, which is used for generating a pulse signal on the basis of a control word, and generating a random number signal according to the pulse signal, wherein the pulse signal comprises first frequency signals and second frequency signals which appear alternately, and the ratio of the first frequency signals to the second frequency signals is controlled by means of the control word; and a feedback update circuit, which is used for updating the control word on the basis of the random number signal output by the random number generation circuit.
A gene modification detection method and an application thereof. The method comprises: obtaining a substance to be detected which has a diameter of 200 nanometers or more in a sample to be detected, and detecting the amount and/or presence of hydroxymethylcytosine in said substance.
Systems and methods for image processing are provided in the present disclosure. The systems may obtain a first image and a second image associated with a same object; determine a plurality of first blocks of the first image and a plurality of second blocks of the second image, the plurality of second blocks and the plurality of first blocks being in one-to-one correspondence; determine a plurality of first characteristic values based on the plurality of first blocks and the plurality of second blocks; and/or generate a first target map associated with the first image and the second image based on the plurality of first characteristic values.
H04N 5/367 - Noise processing, e.g. detecting, correcting, reducing or removing noise applied to fixed-pattern noise, e.g. non-uniformity of response applied to defects, e.g. non-responsive pixels
96.
ENCODING METHOD AND APPARATUS, DECODING METHOD AND APPARATUS, DEVICE, AND READABLE STORAGE MEDIUM
CHINA MOBILE COMMUNICATIONS GROUP CO., LTD. (China)
PEKING UNIVERSITY (China)
Inventor
Feng, Yanan
Li, Lin
Zhou, Bing
Xu, Song
Xing, Gang
Jia, Chuanmin
Ge, Ziqing
Wang, Shanshe
Ma, Siwei
Abstract
The present application relates to the technical field of communications, and discloses an encoding method and apparatus, a decoding method and apparatus, a device, and a readable storage medium, capable of increasing the encoding speed and the decoding speed. The method comprises: obtaining a feature image of an image to be encoded; obtaining a codebook range scaling factor according to the feature image; obtaining a content-adaptive prior codebook range of each channel of the feature image by using the codebook range scaling factor and a channel-adaptive prior codebook range of each channel; and performing entropy encoding on a target channel according an actual character range of the target channel of the feature image and the content-adaptive prior codebook range of the target channel, to form an encoded stream, wherein the target channel is any channel of the feature image.
H04N 19/91 - Entropy coding, e.g. variable length coding [VLC] or arithmetic coding
H04N 19/189 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the adaptation method, adaptation tool or adaptation type used for the adaptive coding
97.
ENCODING METHOD, DECODING METHOD, APPARATUS, DEVICE, AND READABLE STORAGE MEDIUM
CHINA MOBILE COMMUNICATIONS GROUP CO., LTD. (China)
PEKING UNIVERSITY (China)
Inventor
Feng, Yanan
Li, Lin
Zhou, Bing
Xu, Song
Xing, Gang
Ma, Siwei
Wang, Shanshe
Xu, Yiqun
Hu, Wei
Abstract
The present application discloses an encoding method, a decoding method, an apparatus, a device, and a readable storage medium, relating to the technical field of image processing, so as to increase processing performance. The method comprises: clustering point cloud data to be processed in a current frame, to obtain multiple sub-point clouds; generating a generalized Laplacian matrix for any target sub-point cloud of the multiple sub-point clouds, according to Euclidean distances between multiple point pairs in the target sub-point cloud, and a Euclidean distance between a target point in the target sub-point cloud and a point corresponding to the target point; using the generalized Laplacian matrix to perform inter-frame prediction and an image Fourier residual transform on the target sub-point cloud; and separately quantizing and encoding the transformed multiple sub-point clouds, to obtain an encoded code stream; the corresponding point is located in a reference point cloud of the target sub-point cloud, and the reference point cloud is located in a reference frame of the current frame.
H04N 19/52 - Processing of motion vectors by encoding by predictive encoding
H04N 19/61 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using transform coding in combination with predictive coding
98.
BACTERIAL CAPSULAR OLIGOSACCHARIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
A bacterial capsular oligosaccharide derivative, a preparation method therefor, a pharmaceutical composition and a use thereof. The derivative is as shown in formula (I), and the substituent is described in detail in the description. The derivative has anti-inflammatory activity and can be used for treating sepsis.
C07D 309/02 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
99.
METHOD FOR AMPLIFYING ERYTHROID PROGENITORS OR ERYTHROBLASTS, AND APPLICATION THEREOF
A method for amplifying erythroid progenitors or erythroblasts and ultimately producing mature denucleated red blood cells, and an application thereof, specifically comprising using a BRAF kinase inhibitor, and a combination thereof with a TGF-β inhibitor and/or an SMAD2/3 inhibitor and/or a glucocorticoid and/or erythropoietin and/or stem cell factor.
A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
Provided are a single gene test method and an application thereof. Specifically, provided is a gene modification test method, comprising (S1) on the basis of the quantity and/or presence of hydroxymethylcytosine in a clinical examination positive sample and a clinical examination negative sample of a target gene, determining a region to be tested, and (S2) detecting the quantity and/or presence of hydroxymethylcytosine in said region of a sample to be tested.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
patents
