Abstract

The present disclosure provides a method for constructing a real-geographic- space scene in real time based on a panoramic-video technique. By using a measuring robot and the attitude sensors, accurately determining the geographic coordinates and the attitudes of the cameras, wherein the cameras may be installed in a fixed or stringing manner, wherein in the fixing type a plurality of neighboring videos at the same moment undergo orthographic correction and splicing, and in the stringing type the cameras are installed to a guiding device and may locally, independently and quickly move and shoot, and the videos of the neighboring cameras are spliced in real time; and fusing the videos, the geographic coordinates and the environment sounds that satisfy the delay time, to form a scene video streaming.

IPC Classes  ?

• H04N 23/951 - Computational photography systems, e.g. light-field imaging systems by using two or more images to influence resolution, frame rate or aspect ratio
• G02B 27/01 - Head-up displays
• G03B 37/04 - Panoramic or wide-screen photography; Photographing extended surfaces, e.g. for surveying; Photographing internal surfaces, e.g. of pipe with cameras or projectors providing touching or overlapping fields of view

Abstract

Systems and methods for image processing are provided in the present disclosure. The systems may obtain a first image and a second image associated with a same object; determine a plurality of first blocks of the first image and a plurality of second blocks of the second image, the plurality of second blocks and the plurality of first blocks being in one-to-one correspondence; determine a plurality of first characteristic values based on the plurality of first blocks and the plurality of second blocks; and/or generate a first target map associated with the first image and the second image based on the plurality of first characteristic values.

IPC Classes  ?

• G06T 3/40 - Scaling of a whole image or part thereof
• G06T 5/00 - Image enhancement or restoration
• G06T 7/00 - Image analysis

Abstract

Provided are linear RNA precursors and constructs for preparing circular RNAs (circRNAs) comprising from the 5' end to the 3' end: (a) a first portion of an RNA element (such as an IRES), (b) an effector RNA sequence, and (c) a second portion of the RNA element, wherein the first portion of the RNA element and the second portion of the RNA element associate with each other to form a double-stranded region of at least 4 basepairs (bp) long, wherein the 5' end of the first portion of the RNA element and the 3' end of the second portion of the RNA element form a nick in the double-stranded region, and wherein the nick can be ligated by a RNA ligase. Also provided are methods of preparing circRNAs, and circRNAs prepared thereof.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Abstract

Compositions of culture conditions and the stepwise method for improving reprograming of human somatic cells into human chemically induced pluripotent cells are disclosed. The first stage, which uses a combination of small molecules with necessary biological activities, is aimed at downregulating the somatic gene program. The second stage uses a selection of small molecules with select biological activities to upregulate one or more pluripotency-related transcriptional factors. The third stage uses a selection of small molecule factors with select biological activities to establish an initial pluripotency network, measured by the expression of OCT4. The fourth and final stage uses a selection of small molecules with select biological activities to fully establish a pluripotent network, measured by co-expression factors such as OCT4, SOX2, and NANOG in the reprogrammed cells. The resultant reprogrammed cells are termed human chemically induced pluripotent stem cells, hCiPSCs.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present invention provides a porphyrin compound and its preparation method and uses, and also provides a pharmaceutical composition comprising the porphyrin compound as the active ingredient. The porphyrin compound according to the present invention has a novel modified structure, and can be derived and modified at multiple sites to achieve the biocompatibility modification and functional changes. The porphyrin compound has the absorption wavelength located in the near infrared region, which is contributed to realize the deeper tissue penetration and excellent photodynamic therapy activity.

IPC Classes  ?

• C07D 491/22 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains four or more hetero rings
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom

Abstract

The present invention relates to a boron carrying agent for integrated tumor diagnosis and treatment, and a preparation method therefor and use thereof. Provided is a compound represented by formula I:wherein an R group is hydrogen or alkyl. A boron atom connected to the benzene ring may be 10B or natural boron, and at least one fluorine atom in -BF 3 - is radiolabeled. The present invention generally relates to the fields of radiopharmaceuticals and nuclear medicine. The compound in the present invention can be used for a drug for integrated diagnosis and treatment in tumor diagnosis and BNCT treatment, and by means of the same chemical structure, a reliable distribution result of a drug in vivo is provided.

IPC Classes  ?

• C07F 5/02 - Boron compounds

Abstract

Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
• C12N 15/09 - Recombinant DNA-technology

Abstract

Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. Further provided are deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Provided are a method for identifying functional elements of a genomic sequence and a library used for identifying functional elements of a genomic sequence.

IPC Classes  ?

• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C40B 20/00 - Methods specially adapted for identifying library members

Abstract

Compositions, kits and methods are provided for genetic screening using one or more sets of guide RNA constructs having internal barcodes ("iBAR"). Each set has three or more guide RNA constructs targeting the same genomic locus, but embedded with different iBAR sequences.

IPC Classes  ?

• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof

Abstract

Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, and deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Factors for extending the ability of isolated pluripotent stem cells to generate extraembryonic lineages in vivo, following in vitro culture, herein, chemical extenders of pluripotency (CEP). Methods of extending the ability of a pluripotent cell to generate embryonic and extraembryonic lineages. The cell to be reprogrammed is contacted with effective amounts of the CEPs for a sufficient period of time to reprogram the cell into a chemically induced extended pluripotent cell (ciEPSC). ciEPSC are identified as an extended pluripotent cell based on properties including: (i) morphologically and (ii) functionally for example, based on their ability contribute to both TE and ICM, in vivo. The ciEPSCs can be cultured or induced to differentiate into cells of a desired type, and used in a number of applications, including but not limited to cell therapy and tissue engineering.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C12N 5/07 - Animal cells or tissues
• C12N 5/074 - Adult stem cells
• C12N 5/0789 - Stem cells; Multipotent progenitor cells
• C12N 5/0797 - Stem cells; Progenitor cells
• C12N 5/095 - Stem cells; Progenitor cells
• C07K 14/54 - Interleukins (IL)
• C07K 14/715 - Receptors; Cell surface antigens; Cell surface determinants for interferons
• C07K 16/38 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

Disclosed is a use of a SUSD2 protein as a marker, in particular a use of the SUSD2 protein as the marker in identification, selection or separation of pancreatic internal secretion precursor cells and/or newborn pancreatic internal secretion cells; and a use of an mRNA, for encoding the SUSD2 protein, of a precursor protein as the marker in identification of the pancreatic internal secretion precursor cells and/or the newborn pancreatic internal secretion cells.Through analysis of gene expression of pancreatic endoderm cells sourced by induced directional differentiation of human pluripotent stem cells, the enrichment expression of a SUSD2 gene in the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells is found. In addition, a protein encoded by the SUSD2 gene is a receptor protein on cell membranes. Using the protein as the marker, the identification, the selection or the separation of the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells can be carried out, which has an important significance on research about pancreas related cells in each development stage.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

A method for inducing reprograming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.

IPC Classes  ?

• C12N 5/0735 - Embryonic stem cells; Embryonic germ cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/407 - Liver; Hepatocytes
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

Abstract

A method for removing SO x from a gas using an ethylene glycol composite solution is provided. The ethylene glycol composite solution is made by mixing ethylene glycol and/or polyethylene glycol with an organic acid and/or organic acid salt containing no nitrogen atom in a molecule, the ethylene glycol composite solution is brought into contact with the gas containing SO x to absorb the SO x in the gas, wherein x = 2 and/or 3. The ethylene glycol composite solution with absorbed SO x is regenerated by one or more of a heating method, a vacuum method, a gas stripping method, an ultrasonication method, a microwave method, and a radiation method to release by-products of sulfur dioxide and sulfur trioxide, and the regenerated ethylene glycol composite solution is recycled for use. This method can be used for desulfurization of flue gas, burning gas, coke-oven gas, synthesis waste gas from dyestuff plants, sewage gas from chemical fiber plants, and other industrial raw material gases or waste gases containing SO x.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption

Abstract

A method for removing SOx from a gas by using a polyol composite solution is provided. The polyol composite solution is made by mixing a polyol with an organic acid and/or organic acid salt, the polyol composite solution is brought into contact with the gas containing SOx to absorb the SOx in the gas, wherein x = 2 and/or 3, and the polyol refers to an organic compound other than ethylene glycol and polyethylene glycol, which contains simultaneously two or more than two hydroxyl groups in a same organic molecule.

IPC Classes  ?

• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/50 - Sulfur oxides
• B01D 53/96 - Regeneration, reactivation or recycling of reactants

Abstract

A method for removing SO x from a gas by using a compound alcohol-amine solution is provided. The compound alcohol-amine solution is made by mixing ethylene glycol and/or polyethylene glycol with hydroxyl and/or carboxyl organic compound having basic group containing nitrogen. The compound alcohol-amine solution is contacted with the gas containing SO x to absorb the SO x in the gas, wherein x = 2 and/or 3. The compound alcohol-amine solution with absorbed SO x is regenerated by one or more of heating method, vacuum method, gas stripping method, ultrasonic method, microwave method, and radiation method to release by-products of sulfur dioxide and sulfur trioxide, and the regenerated compound alcohol-amine solution is recycled for use. This method can be used for removing SO x from flue gas, burning gas, coke-oven gas, synthesis waste gas from dyestuff plants, sewage gas from chemical fiber plants, and other industrial raw material gases or waste gases containing SO x.

IPC Classes  ?

• B01D 53/79 - Injecting reactants
• B01D 53/50 - Sulfur oxides
• B01D 53/96 - Regeneration, reactivation or recycling of reactants

Abstract

A method for removing SO x from a gas by using a modified polyethylene glycol solution to absorb the SO x in the gas. The modified polyethylene glycol solution is contacted with the gas containing SO x to absorb the SO x in the gas, wherein x = 2 and/or 3, the modified polyethylene glycol is a product derived from etherifying hydroxyl groups in the molecules of ethylene glycol and/or polyethylene glycol and has a general formula: R1-(O-C2H4)n-O-R2, where n is a positive integer, R1 and R2 are the same or different and are each independently alkyl, alkenyl, alkynyl, acyl or aryl.

IPC Classes  ?

• B01D 53/50 - Sulfur oxides
• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption

Abstract

Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR4-related diseases. (see formula I)

IPC Classes  ?

• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 11/06 - Antiasthmatics
• A61P 17/00 - Drugs for dermatological disorders

Abstract

The invention discloses a method of extracting nucleic acid analyte solution from biological sample, comprising: placing the biological sample into a heating container; optionally, adding solvent medium into the biological sample; heating the biological sample under high pressure; optionally, centrifuging the biological sample; and obtaining the solution including the nucleic acid analyte. The invention also discloses a method of detecting the nucleic acid analyte obtained by said extraction method.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

A method for removing SO x (x=2 and/or 3) from gas using a solution having polyethylene glycol as the main ingredient. First, SO x in the gas is absorbed by the solution of polyethylene glycol. Second, the solution of polyethylene glycol which has absorbed SO x is regenerated by one or more of the heating, vacuum, ultrasonic, microwave or radiation methods, thereby releasing the by-products of sulfur dioxide and sulfur trioxide. The regenerated solution of polyethylene glycol is recycled. When the water content of the regenerated solution of polyethylene glycol is high enough to affect the desulfurization, it needs to be removed. Removal methods include heating and rectification, absorption using a water absorbent, or a combination of these methods. The polyethylene glycol solution is recycled after dehydration.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/50 - Sulfur oxides