PRODUCTION OF MHC II/CII COMPLEXES

Register WIPO Patent
Application Number EP2020072287
Publication Number 2021/028350
Status In Force
Filing Date 2020-08-07
Publication Date 2021-02-18
Owner FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Germany)
Inventor
  • Schneider, Dr. Nadine
  • Xu, Bingze
  • Cienciala, Sylvia
  • Holmdahl, Prof. Rikard
  • Burkhardt, Prof. Dr. Harald

Abstract

[142] The present invention relates to in situ glycosylated MHC II/CII peptide complexes, i.e., complexes naturally glycosylated during recombinant protein expression in the host cell. The invention further relates to methods of producing glycosylated MHC II/CII peptide complexes in mammalian cells. Furthermore the invention relates to the use of such post-translationally modified, preferably glycosylated MHC/CII complexed for use in treating rheumatoid arthritis, preferably in humans.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
  • A61P 37/00 - Drugs for immunological or allergic disorders